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ENCSR904DTN: DNase-seq of mouse liver in constant darkness

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for Phox2a

Z-value: 1.02

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Transcription factors associated with Phox2a

Gene Symbol	Gene ID	Gene Info
Phox2a Ensembl NCBI MGI UniProt	ENSMUSG00000007946.9	Phox2a

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

Gene	Promoter	Distance	Association probability	Pearson corr. coef.	P-value	Plot
Phox2a	chr7_101822093_101822270	1435	0.218398	-0.75	8.3e-02	Click!
Phox2a	chr7_101821639_101821825	986	0.333450	-0.50	3.1e-01	Click!

Activity of the Phox2a motif across conditions

Conditions sorted by the z-value of the Phox2a motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr2_18048778_18049088	1.25	Skida1	SKI/DACH domain containing 1	98	0.94
chr17_80022007_80022158	1.03	Gm22215	predicted gene, 22215	11432	0.14
chr19_44401346_44401497	0.93	Scd1	stearoyl-Coenzyme A desaturase 1	5269	0.16
chr12_75531904_75532183	0.92	Ppp2r5e	protein phosphatase 2, regulatory subunit B', epsilon	17631	0.18
chr1_51740463_51740849	0.86	Gm28055	predicted gene 28055	6287	0.22
chr11_30792834_30792985	0.83	Psme4	proteasome (prosome, macropain) activator subunit 4	18628	0.14
chr7_65902304_65902456	0.83	Pcsk6	proprotein convertase subtilisin/kexin type 6	39948	0.14
chr6_52610697_52610915	0.82	Gm44434	predicted gene, 44434	7561	0.15
chr4_44777019_44777170	0.77	Zcchc7	zinc finger, CCHC domain containing 7	16650	0.16
chr7_84113279_84113524	0.77	Cemip	cell migration inducing protein, hyaluronan binding	26899	0.14
chr19_3864646_3865022	0.76	Gm50383	predicted gene, 50383	2839	0.13
chr19_3872249_3872405	0.73	Chka	choline kinase alpha	2337	0.14
chr7_30967090_30967447	0.65	Lsr	lipolysis stimulated lipoprotein receptor	6054	0.07
chr13_117745874_117746186	0.65	4933413L06Rik	RIKEN cDNA 4933413L06 gene	26019	0.26
chr2_158093657_158093889	0.64	2010009K17Rik	RIKEN cDNA 2010009K17 gene	1976	0.28
chr1_23237656_23237879	0.63	Gm29506	predicted gene 29506	2094	0.23
chr18_39438249_39438499	0.60	Nr3c1	nuclear receptor subfamily 3, group C, member 1	48858	0.13
chr8_12804734_12804948	0.60	Atp11a	ATPase, class VI, type 11A	6575	0.17
chr12_28636385_28636550	0.58	Rps7	ribosomal protein S7	514	0.71
chr12_51274477_51274668	0.56	Rps11-ps4	ribosomal protein S11, pseudogene 4	22915	0.22
chr12_73861884_73862127	0.56	Gm15283	predicted gene 15283	7607	0.18
chr4_106354190_106354378	0.56	Usp24	ubiquitin specific peptidase 24	38050	0.13
chr4_15212980_15213172	0.55	Tmem64	transmembrane protein 64	52755	0.13
chr10_4618620_4618773	0.55	Esr1	estrogen receptor 1 (alpha)	6675	0.25
chr2_67977965_67978321	0.54	Gm37964	predicted gene, 37964	79547	0.1
chr12_73341772_73342027	0.54	Slc38a6	solute carrier family 38, member 6	2468	0.25
chr11_22844106_22844418	0.53	Gm23772	predicted gene, 23772	2606	0.17
chr1_13368915_13369352	0.52	Ncoa2	nuclear receptor coactivator 2	3296	0.16
chr19_48883437_48883771	0.51	Gm50436	predicted gene, 50436	72468	0.11
chr9_112785054_112785229	0.51	Gm24957	predicted gene, 24957	262612	0.02
chr6_119380906_119381057	0.50	Adipor2	adiponectin receptor 2	7705	0.21
chr17_88605968_88606119	0.49	Gm9406	predicted gene 9406	2501	0.24
chr9_112123334_112123526	0.49	Mir128-2	microRNA 128-2	4719	0.29
chr16_92631807_92631997	0.48	Gm26626	predicted gene, 26626	19088	0.2
chr13_118829008_118829159	0.48	Gm47335	predicted gene, 47335	29331	0.22
chr8_35495669_35495888	0.47	Eri1	exoribonuclease 1	245	0.93
chr12_85291673_85291832	0.47	Zc2hc1c	zinc finger, C2HC-type containing 1C	3161	0.14
chr5_138080510_138080792	0.47	Zkscan1	zinc finger with KRAB and SCAN domains 1	4433	0.1
chr19_44400352_44400581	0.47	Scd1	stearoyl-Coenzyme A desaturase 1	6224	0.15
chr9_69333993_69334216	0.47	Gm15511	predicted gene 15511	30143	0.16
chr6_122148793_122148971	0.46	Gm10319	predicted pseudogene 10319	12150	0.17
chr17_17234200_17234351	0.46	Gm5165	predicted gene 5165	597	0.78
chr9_53291516_53291691	0.45	Exph5	exophilin 5	10067	0.19
chr18_3465417_3465568	0.45	Gm50088	predicted gene, 50088	1010	0.43
chr3_131485378_131485553	0.45	Sgms2	sphingomyelin synthase 2	5014	0.28
chr4_123990670_123991070	0.44	Gm12902	predicted gene 12902	64636	0.08
chr2_107628721_107628872	0.44	Gm9864	predicted gene 9864	28257	0.26
chr15_82404193_82404671	0.44	Cyp2d10	cytochrome P450, family 2, subfamily d, polypeptide 10	1535	0.14
chr16_65665507_65665824	0.43	Gm49633	predicted gene, 49633	52246	0.14
chr5_87030613_87030972	0.43	Gm18635	predicted gene, 18635	16632	0.1
chr17_84997546_84997697	0.42	Ppm1b	protein phosphatase 1B, magnesium dependent, beta isoform	3941	0.22
chr2_150913728_150914090	0.42	Gins1	GINS complex subunit 1 (Psf1 homolog)	1090	0.37
chr13_93710959_93711124	0.42	Dmgdh	dimethylglycine dehydrogenase precursor	498	0.72
chr19_7182336_7182545	0.41	Otub1	OTU domain, ubiquitin aldehyde binding 1	18024	0.12
chr5_134177966_134178117	0.41	Rcc1l	reculator of chromosome condensation 1 like	1267	0.3
chr17_18321520_18321874	0.41	Vmn2r93	vomeronasal 2, receptor 93	23598	0.19
chr6_38794603_38794986	0.41	Hipk2	homeodomain interacting protein kinase 2	23552	0.21
chr10_31551438_31551618	0.41	Gm47693	predicted gene, 47693	5912	0.19
chr11_42198938_42199110	0.41	Gabra1	gamma-aminobutyric acid (GABA) A receptor, subunit alpha 1	16094	0.28
chr14_65740190_65740357	0.41	Scara5	scavenger receptor class A, member 5	63796	0.1
chr19_30093178_30093359	0.41	Uhrf2	ubiquitin-like, containing PHD and RING finger domains 2	1307	0.48
chr18_16822318_16822486	0.41	Gm15328	predicted gene 15328	5995	0.21
chr6_6213107_6213286	0.41	Slc25a13	solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 13	3922	0.28
chr19_6919936_6920100	0.41	Esrra	estrogen related receptor, alpha	1033	0.26
chr2_125783158_125783336	0.40	Secisbp2l	SECIS binding protein 2-like	377	0.89
chr17_81386211_81386362	0.40	Gm50044	predicted gene, 50044	15453	0.24
chr11_4095549_4095867	0.40	Mtfp1	mitochondrial fission process 1	263	0.83
chr4_109104769_109104920	0.39	Osbpl9	oxysterol binding protein-like 9	3187	0.27
chr12_4220651_4220920	0.39	Gm48210	predicted gene, 48210	1317	0.27
chr2_103461502_103462486	0.39	Elf5	E74-like factor 5	13256	0.17
chr13_37756552_37756712	0.39	Gm31600	predicted gene, 31600	5116	0.16
chr14_68299957_68300145	0.38	Gm47212	predicted gene, 47212	81798	0.09
chr16_94606252_94606403	0.38	Gm15971	predicted gene 15971	14050	0.19
chr16_78470224_78470428	0.38	Gm49603	predicted gene, 49603	10213	0.17
chr17_33667328_33667604	0.38	Hnrnpm	heterogeneous nuclear ribonucleoprotein M	896	0.43
chr12_111819707_111819858	0.38	Zfyve21	zinc finger, FYVE domain containing 21	3526	0.14
chr2_160865219_160865594	0.38	Zhx3	zinc fingers and homeoboxes 3	5775	0.14
chr10_20723719_20723889	0.38	Pde7b	phosphodiesterase 7B	892	0.65
chr7_101838012_101838169	0.38	Inppl1	inositol polyphosphate phosphatase-like 1	37	0.7
chr19_53904567_53904727	0.37	Pdcd4	programmed cell death 4	1231	0.39
chr5_125526040_125526191	0.37	Tmem132b	transmembrane protein 132B	5659	0.17
chr15_6218493_6218848	0.37	Gm23139	predicted gene, 23139	67322	0.11
chr1_151154930_151155204	0.37	C730036E19Rik	RIKEN cDNA C730036E19 gene	17033	0.11
chr3_94339066_94339223	0.36	Them5	thioesterase superfamily member 5	2955	0.11
chr11_115919240_115919538	0.36	Recql5os1	RecQ-like 5, opposite strand 1	5638	0.09
chr19_21654390_21654886	0.36	Abhd17b	abhydrolase domain containing 17B	1113	0.45
chr16_13359323_13359477	0.36	Mrtfb	myocardin related transcription factor B	979	0.59
chr13_37854787_37854958	0.36	Rreb1	ras responsive element binding protein 1	3062	0.27
chr8_41069792_41069999	0.35	Mtus1	mitochondrial tumor suppressor 1	12881	0.16
chr14_25916848_25916999	0.35	Tmem254a	transmembrane protein 254a	8865	0.12
chr6_72120521_72121047	0.35	4933431G14Rik	RIKEN cDNA 4933431G14 gene	2156	0.2
chr9_48787462_48787613	0.35	Zbtb16	zinc finger and BTB domain containing 16	48408	0.15
chr7_49458254_49458469	0.34	Nav2	neuron navigator 2	7601	0.23
chr12_12940858_12941058	0.34	Mycn	v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived	342	0.83
chr13_23299091_23299367	0.34	Gm11333	predicted gene 11333	1180	0.26
chr4_126764112_126764263	0.34	AU040320	expressed sequence AU040320	10361	0.13
chr12_80336463_80336614	0.34	Dcaf5	DDB1 and CUL4 associated factor 5	40154	0.1
chr14_26056611_26056762	0.34	Tmem254c	transmembrane protein 254c	8855	0.11
chr3_69543570_69543742	0.34	Ppm1l	protein phosphatase 1 (formerly 2C)-like	1224	0.48
chr4_116838867_116839391	0.34	Rpl36-ps8	ribosomal protein L36, pseudogene 8	1092	0.3
chr1_74003708_74004000	0.34	Tns1	tensin 1	2287	0.36
chr18_39427173_39427361	0.34	Gm15337	predicted gene 15337	37842	0.16
chr16_37566906_37567176	0.33	Rabl3	RAB, member RAS oncogene family-like 3	3307	0.18
chr8_117738226_117738377	0.33	Gm31774	predicted gene, 31774	9959	0.14
chr18_35306593_35306763	0.33	Sil1	endoplasmic reticulum chaperone SIL1 homolog (S. cerevisiae)	6863	0.2
chrX_38400123_38400274	0.33	Gm4853	predicted pseudogene 4853	3263	0.22
chr9_119401641_119401816	0.33	Acvr2b	activin receptor IIB	390	0.77
chr2_35098773_35098970	0.33	AI182371	expressed sequence AI182371	1813	0.3
chr5_30286285_30286785	0.32	Drc1	dynein regulatory complex subunit 1	5147	0.17
chr3_52854941_52855092	0.32	Gm30292	predicted gene, 30292	57231	0.11
chr13_4205379_4205553	0.32	Akr1c13	aldo-keto reductase family 1, member C13	11608	0.13
chr9_89704333_89704504	0.32	Tmed3	transmembrane p24 trafficking protein 3	405	0.82
chr17_64607771_64607970	0.32	Man2a1	mannosidase 2, alpha 1	7134	0.26
chr9_67840552_67841087	0.32	Vps13c	vacuolar protein sorting 13C	407	0.85
chr6_144895356_144895507	0.32	Gm22792	predicted gene, 22792	91799	0.07
chr5_147545326_147545477	0.32	Pan3	PAN3 poly(A) specific ribonuclease subunit	6124	0.21
chr9_62023104_62023499	0.32	Paqr5	progestin and adipoQ receptor family member V	3500	0.27
chr6_120318643_120318978	0.31	B4galnt3	beta-1,4-N-acetyl-galactosaminyl transferase 3	24251	0.15
chr11_35750589_35750898	0.31	Pank3	pantothenate kinase 3	18741	0.16
chr10_82740996_82741147	0.31	Nfyb	nuclear transcription factor-Y beta	10588	0.13
chr6_33823830_33824315	0.31	Exoc4	exocyst complex component 4	38028	0.2
chr12_75735898_75736072	0.31	Sgpp1	sphingosine-1-phosphate phosphatase 1	256	0.94
chr5_64337855_64338006	0.31	Gm6044	predicted gene 6044	17674	0.13
chr3_146778044_146778430	0.31	Prkacb	protein kinase, cAMP dependent, catalytic, beta	3179	0.23
chr2_122737415_122737579	0.31	Bloc1s6os	biogenesis of lysosomal organelles complex-1, subunit 6, pallidin, opposite strand	865	0.39
chr17_88614606_88614762	0.30	Gm9406	predicted gene 9406	6140	0.17
chr4_152741969_152742142	0.30	Gm833	predicted gene 833	44515	0.17
chr4_105198345_105198538	0.30	Plpp3	phospholipid phosphatase 3	41094	0.19
chr6_65569857_65570008	0.30	Tnip3	TNFAIP3 interacting protein 3	20466	0.22
chr6_37510078_37510463	0.29	Akr1d1	aldo-keto reductase family 1, member D1	19903	0.21
chr3_19997345_19997496	0.29	Cp	ceruloplasmin	8268	0.18
chr9_89882776_89882950	0.29	Rasgrf1	RAS protein-specific guanine nucleotide-releasing factor 1	27045	0.16
chr15_16844404_16844562	0.29	Gm49127	predicted gene, 49127	6481	0.3
chr14_119831250_119831463	0.29	4930404K13Rik	RIKEN cDNA 4930404K13 gene	32378	0.19
chr5_124025292_124025465	0.29	Vps37b	vacuolar protein sorting 37B	6880	0.1
chr11_120695384_120695739	0.29	Aspscr1	alveolar soft part sarcoma chromosome region, candidate 1 (human)	6251	0.07
chr16_18071409_18071560	0.29	Dgcr6	DiGeorge syndrome critical region gene 6	2004	0.23
chr14_20956319_20956501	0.29	Vcl	vinculin	27012	0.18
chr12_77681559_77681753	0.28	4930458K08Rik	RIKEN cDNA 4930458K08 gene	1405	0.49
chr1_162867938_162868165	0.28	Fmo1	flavin containing monooxygenase 1	1441	0.39
chr14_9492266_9492441	0.28	Gm48371	predicted gene, 48371	22798	0.26
chr7_132941355_132941506	0.28	Zranb1	zinc finger, RAN-binding domain containing 1	6738	0.15
chr2_31502991_31503411	0.27	Ass1	argininosuccinate synthetase 1	2475	0.27
chr4_32561294_32561627	0.27	Bach2os	BTB and CNC homology 2, opposite strand	10157	0.16
chr10_43441199_43441579	0.27	Gm3699	predicted gene 3699	15112	0.13
chr2_75605802_75605972	0.27	Gm13655	predicted gene 13655	27495	0.15
chr15_3463467_3463618	0.27	Ghr	growth hormone receptor	8102	0.29
chr2_34049474_34049625	0.27	C230014O12Rik	RIKEN cDNA C230014O12 gene	58180	0.11
chr3_148832133_148832284	0.27	Adgrl2	adhesion G protein-coupled receptor L2	1720	0.51
chr1_145995029_145995180	0.27	Gm5263	predicted gene 5263	425332	0.01
chr2_71499002_71499251	0.27	Gm23253	predicted gene, 23253	3855	0.16
chr1_167414950_167415113	0.27	Mgst3	microsomal glutathione S-transferase 3	21190	0.15
chr6_59412258_59412432	0.27	Gprin3	GPRIN family member 3	13949	0.29
chr14_26196215_26196366	0.26	Tmem254b	transmembrane protein 254b	8867	0.12
chr1_85165585_85165793	0.26	Gm6264	predicted gene 6264	4826	0.12
chr9_46479855_46480133	0.26	Gm47144	predicted gene, 47144	25079	0.15
chr8_108703572_108703757	0.26	Zfhx3	zinc finger homeobox 3	564	0.82
chr15_76269579_76269775	0.26	Mirt2	myocardial infraction associated transcript 2	52	0.92
chr10_45048433_45048599	0.26	Prep	prolyl endopeptidase	18687	0.15
chr19_31886956_31887132	0.26	A1cf	APOBEC1 complementation factor	18263	0.2
chr19_56821183_56821529	0.25	Ccdc186	coiled-coil domain containing 186	834	0.58
chr10_81407875_81408026	0.25	Nfic	nuclear factor I/C	309	0.68
chr10_31594029_31594273	0.25	Rnf217	ring finger protein 217	15033	0.16
chr4_101198122_101198415	0.25	Gm24468	predicted gene, 24468	11504	0.14
chr8_46365811_46365999	0.25	Gm30931	predicted gene, 30931	2649	0.2
chr8_36739901_36740056	0.25	Dlc1	deleted in liver cancer 1	6924	0.31
chr4_80919092_80919518	0.25	Lurap1l	leucine rich adaptor protein 1-like	8659	0.26
chr1_63136268_63136443	0.25	Ndufs1	NADH:ubiquinone oxidoreductase core subunit S1	8606	0.09
chr18_61841168_61841343	0.25	Afap1l1	actin filament associated protein 1-like 1	54553	0.1
chr1_23913075_23913318	0.25	Smap1	small ArfGAP 1	3460	0.31
chr2_157131528_157131679	0.25	Samhd1	SAM domain and HD domain, 1	1546	0.33
chr18_44633864_44634028	0.24	A930012L18Rik	RIKEN cDNA A930012L18 gene	27719	0.19
chr3_83048403_83048757	0.24	Fgb	fibrinogen beta chain	1283	0.37
chr2_72309170_72309345	0.24	Map3k20	mitogen-activated protein kinase kinase kinase 20	11356	0.19
chr10_25563128_25563279	0.24	Gm29571	predicted gene 29571	26817	0.14
chr5_102010214_102010423	0.24	Wdfy3	WD repeat and FYVE domain containing 3	28760	0.16
chr15_36375228_36375396	0.24	Gm34150	predicted gene, 34150	263	0.88
chr14_65375161_65375312	0.24	Zfp395	zinc finger protein 395	157	0.95
chr10_69268049_69268226	0.24	Rhobtb1	Rho-related BTB domain containing 1	2500	0.29
chr16_17069481_17069751	0.24	Ypel1	yippee like 1	80	0.93
chr8_121898077_121898240	0.23	Slc7a5	solute carrier family 7 (cationic amino acid transporter, y+ system), member 5	1656	0.23
chr17_29711245_29711660	0.23	Ccdc167	coiled-coil domain containing 167	5511	0.14
chr15_64309233_64309403	0.23	Asap1	ArfGAP with SH3 domain, ankyrin repeat and PH domain1	2371	0.28
chr6_138138988_138139150	0.23	Mgst1	microsomal glutathione S-transferase 1	1247	0.59
chr4_57160943_57161117	0.23	Gm12530	predicted gene 12530	11041	0.2
chr11_38683198_38683743	0.23	Gm23520	predicted gene, 23520	114807	0.07
chr13_93629307_93629685	0.23	Gm15622	predicted gene 15622	4114	0.18
chr10_62592617_62592774	0.23	Ddx21	DEAD (Asp-Glu-Ala-Asp) box polypeptide 21	1724	0.23
chr1_127787130_127787281	0.23	Ccnt2	cyclin T2	9366	0.16
chr4_124809297_124809476	0.23	Mtf1	metal response element binding transcription factor 1	6708	0.1
chr19_39108442_39108835	0.23	Cyp2c66	cytochrome P450, family 2, subfamily c, polypeptide 66	5260	0.24
chr19_24153611_24153973	0.23	Gm50308	predicted gene, 50308	278	0.9
chr8_46908148_46908299	0.23	1700011L03Rik	RIKEN cDNA 1700011L03 gene	40576	0.13
chr2_4895477_4895652	0.23	Sephs1	selenophosphate synthetase 1	11180	0.15
chr4_55245568_55245866	0.23	Gm12508	predicted gene 12508	9023	0.17
chr1_162813245_162813512	0.23	Fmo4	flavin containing monooxygenase 4	294	0.9
chr7_75852856_75853007	0.23	Klhl25	kelch-like 25	4490	0.26
chr2_118300879_118301335	0.23	1700054M17Rik	RIKEN cDNA 1700054M17 gene	3807	0.17
chr2_132247965_132248291	0.23	Tmem230	transmembrane protein 230	321	0.83
chr11_106889132_106889465	0.23	Smurf2	SMAD specific E3 ubiquitin protein ligase 2	30977	0.11

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of Phox2a

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:1903966	monounsaturated fatty acid metabolic process(GO:1903964) monounsaturated fatty acid biosynthetic process(GO:1903966)
0.1	0.2	GO:0006562	proline catabolic process(GO:0006562)
0.1	0.4	GO:0000467	exonucleolytic trimming involved in rRNA processing(GO:0000459) exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000467)
0.1	0.3	GO:0045053	protein retention in Golgi apparatus(GO:0045053)
0.1	0.2	GO:1904059	regulation of locomotor rhythm(GO:1904059)
0.0	0.3	GO:0033211	adiponectin-activated signaling pathway(GO:0033211)
0.0	0.3	GO:0060836	lymphatic endothelial cell differentiation(GO:0060836)
0.0	0.1	GO:0060523	prostate epithelial cord elongation(GO:0060523)
0.0	0.1	GO:0043490	malate-aspartate shuttle(GO:0043490)
0.0	0.1	GO:0070103	regulation of interleukin-6-mediated signaling pathway(GO:0070103)
0.0	0.3	GO:0035999	tetrahydrofolate interconversion(GO:0035999)
0.0	0.1	GO:0007354	zygotic determination of anterior/posterior axis, embryo(GO:0007354)
0.0	0.2	GO:0042737	drug catabolic process(GO:0042737)
0.0	0.3	GO:0046337	phosphatidylethanolamine metabolic process(GO:0046337)
0.0	0.1	GO:0021564	vagus nerve development(GO:0021564)
0.0	0.1	GO:0036091	positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress(GO:0036091)
0.0	0.1	GO:0070340	detection of bacterial lipopeptide(GO:0070340)
0.0	0.1	GO:0006982	response to lipid hydroperoxide(GO:0006982)
0.0	0.1	GO:1990086	lens fiber cell apoptotic process(GO:1990086)
0.0	0.4	GO:0006670	sphingosine metabolic process(GO:0006670)
0.0	0.1	GO:1900019	regulation of protein kinase C activity(GO:1900019) positive regulation of protein kinase C activity(GO:1900020)
0.0	0.1	GO:0021555	midbrain-hindbrain boundary morphogenesis(GO:0021555)
0.0	0.3	GO:0045631	regulation of auditory receptor cell differentiation(GO:0045607) regulation of mechanoreceptor differentiation(GO:0045631) regulation of inner ear receptor cell differentiation(GO:2000980)
0.0	0.2	GO:2000324	positive regulation of glucocorticoid receptor signaling pathway(GO:2000324)
0.0	0.1	GO:0010499	proteasomal ubiquitin-independent protein catabolic process(GO:0010499)
0.0	0.1	GO:0010792	DNA double-strand break processing involved in repair via single-strand annealing(GO:0010792)
0.0	0.1	GO:0006741	NADP biosynthetic process(GO:0006741)
0.0	0.1	GO:0070947	neutrophil mediated killing of fungus(GO:0070947)
0.0	0.1	GO:0016554	cytidine to uridine editing(GO:0016554)
0.0	0.1	GO:1902897	regulation of postsynaptic density protein 95 clustering(GO:1902897)
0.0	0.1	GO:0007039	protein catabolic process in the vacuole(GO:0007039)
0.0	0.2	GO:0070562	regulation of vitamin D receptor signaling pathway(GO:0070562)
0.0	0.3	GO:0043569	negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569)
0.0	0.1	GO:0046618	drug export(GO:0046618)
0.0	0.1	GO:0090168	Golgi reassembly(GO:0090168)
0.0	0.2	GO:0090308	regulation of methylation-dependent chromatin silencing(GO:0090308)
0.0	0.2	GO:0006573	valine metabolic process(GO:0006573)
0.0	0.1	GO:2001286	regulation of caveolin-mediated endocytosis(GO:2001286)
0.0	0.1	GO:1903774	positive regulation of viral budding via host ESCRT complex(GO:1903774)
0.0	0.2	GO:1902969	mitotic DNA replication(GO:1902969)
0.0	0.1	GO:0034755	iron ion transmembrane transport(GO:0034755)
0.0	0.2	GO:0070995	NADPH oxidation(GO:0070995)
0.0	0.1	GO:0010046	response to mycotoxin(GO:0010046)
0.0	0.1	GO:2001184	positive regulation of interleukin-12 secretion(GO:2001184)
0.0	0.0	GO:0000432	regulation of transcription from RNA polymerase II promoter by glucose(GO:0000430) positive regulation of transcription from RNA polymerase II promoter by glucose(GO:0000432)
0.0	0.1	GO:0044339	canonical Wnt signaling pathway involved in osteoblast differentiation(GO:0044339)
0.0	0.1	GO:0046271	phenylpropanoid catabolic process(GO:0046271)
0.0	0.1	GO:0043152	induction of bacterial agglutination(GO:0043152)
0.0	0.2	GO:0033601	positive regulation of mammary gland epithelial cell proliferation(GO:0033601)
0.0	0.1	GO:0071336	regulation of hair follicle cell proliferation(GO:0071336)
0.0	0.1	GO:1902018	negative regulation of cilium assembly(GO:1902018)
0.0	0.1	GO:0001842	neural fold formation(GO:0001842)
0.0	0.1	GO:0006499	N-terminal protein myristoylation(GO:0006499)
0.0	0.1	GO:0070163	adiponectin secretion(GO:0070162) regulation of adiponectin secretion(GO:0070163)
0.0	0.1	GO:0006203	dGTP catabolic process(GO:0006203)
0.0	0.1	GO:0006654	phosphatidic acid biosynthetic process(GO:0006654) phosphatidic acid metabolic process(GO:0046473)
0.0	0.1	GO:0019805	quinolinate biosynthetic process(GO:0019805)
0.0	0.1	GO:1904694	negative regulation of vascular smooth muscle contraction(GO:1904694)
0.0	0.2	GO:0000290	deadenylation-dependent decapping of nuclear-transcribed mRNA(GO:0000290)
0.0	0.1	GO:2001256	regulation of store-operated calcium entry(GO:2001256)
0.0	0.1	GO:0098728	germ-line stem cell division(GO:0042078) male germ-line stem cell asymmetric division(GO:0048133) germline stem cell asymmetric division(GO:0098728)
0.0	0.1	GO:0019086	late viral transcription(GO:0019086)
0.0	0.2	GO:0034393	positive regulation of smooth muscle cell apoptotic process(GO:0034393)
0.0	0.1	GO:0001827	inner cell mass cell fate commitment(GO:0001827)
0.0	0.0	GO:0000436	carbon catabolite regulation of transcription from RNA polymerase II promoter(GO:0000429) carbon catabolite activation of transcription from RNA polymerase II promoter(GO:0000436)
0.0	0.1	GO:0018199	peptidyl-glutamine modification(GO:0018199)
0.0	0.0	GO:1901656	glycoside transport(GO:1901656)
0.0	0.0	GO:0061113	pancreas morphogenesis(GO:0061113)
0.0	0.1	GO:0032264	IMP salvage(GO:0032264)
0.0	0.2	GO:0035810	positive regulation of urine volume(GO:0035810)
0.0	0.0	GO:0014732	skeletal muscle atrophy(GO:0014732)
0.0	0.1	GO:0035871	protein K11-linked deubiquitination(GO:0035871)
0.0	0.1	GO:0070072	vacuolar proton-transporting V-type ATPase complex assembly(GO:0070072)
0.0	0.0	GO:0060528	secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development(GO:0060528)
0.0	0.1	GO:0046813	receptor-mediated virion attachment to host cell(GO:0046813)
0.0	0.1	GO:0030388	fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.0	0.1	GO:0030309	poly-N-acetyllactosamine metabolic process(GO:0030309) poly-N-acetyllactosamine biosynthetic process(GO:0030311)
0.0	0.1	GO:0050882	voluntary musculoskeletal movement(GO:0050882)
0.0	0.1	GO:0006526	arginine biosynthetic process(GO:0006526)
0.0	0.0	GO:0021882	regulation of transcription from RNA polymerase II promoter involved in forebrain neuron fate commitment(GO:0021882)
0.0	0.0	GO:0019464	glycine catabolic process(GO:0006546) glycine decarboxylation via glycine cleavage system(GO:0019464)
0.0	0.0	GO:0001712	ectodermal cell fate commitment(GO:0001712)
0.0	0.1	GO:0071985	multivesicular body sorting pathway(GO:0071985)
0.0	0.0	GO:0001692	histamine metabolic process(GO:0001692)
0.0	0.0	GO:0060399	positive regulation of growth hormone receptor signaling pathway(GO:0060399)
0.0	0.1	GO:0000707	meiotic DNA recombinase assembly(GO:0000707)
0.0	0.0	GO:0006714	sesquiterpenoid metabolic process(GO:0006714)
0.0	0.1	GO:0051661	maintenance of centrosome location(GO:0051661)
0.0	0.0	GO:0018364	peptidyl-glutamine methylation(GO:0018364)
0.0	0.1	GO:0036015	response to interleukin-3(GO:0036015) cellular response to interleukin-3(GO:0036016)
0.0	0.0	GO:0035054	embryonic heart tube anterior/posterior pattern specification(GO:0035054)
0.0	0.1	GO:0050942	positive regulation of pigment cell differentiation(GO:0050942)
0.0	0.0	GO:0060744	thelarche(GO:0042695) mammary gland branching involved in thelarche(GO:0060744)
0.0	0.1	GO:0019243	methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione(GO:0019243) methylglyoxal catabolic process(GO:0051596) methylglyoxal catabolic process to lactate(GO:0061727)
0.0	0.0	GO:0006703	estrogen biosynthetic process(GO:0006703)
0.0	0.0	GO:0010446	response to alkaline pH(GO:0010446)
0.0	0.0	GO:0003223	ventricular compact myocardium morphogenesis(GO:0003223)
0.0	0.0	GO:0010760	negative regulation of macrophage chemotaxis(GO:0010760)
0.0	0.1	GO:0001561	fatty acid alpha-oxidation(GO:0001561)
0.0	0.1	GO:0006517	protein deglycosylation(GO:0006517)
0.0	0.1	GO:0006572	tyrosine catabolic process(GO:0006572)
0.0	0.1	GO:0009642	response to light intensity(GO:0009642)
0.0	0.0	GO:0000715	nucleotide-excision repair, DNA damage recognition(GO:0000715)
0.0	0.1	GO:1901621	negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning(GO:1901621)
0.0	0.1	GO:0071447	cellular response to hydroperoxide(GO:0071447)
0.0	0.0	GO:0071233	response to leucine(GO:0043201) cellular response to leucine(GO:0071233)
0.0	0.1	GO:0071420	cellular response to histamine(GO:0071420)
0.0	0.0	GO:1902630	regulation of membrane hyperpolarization(GO:1902630)
0.0	0.0	GO:0060164	regulation of timing of neuron differentiation(GO:0060164)
0.0	0.3	GO:0000266	mitochondrial fission(GO:0000266)
0.0	0.1	GO:0045721	negative regulation of gluconeogenesis(GO:0045721)
0.0	0.1	GO:0006398	mRNA 3'-end processing by stem-loop binding and cleavage(GO:0006398)
0.0	0.0	GO:0044004	killing by symbiont of host cells(GO:0001907) disruption by symbiont of host cell(GO:0044004)
0.0	0.1	GO:0070236	negative regulation of activation-induced cell death of T cells(GO:0070236)
0.0	0.0	GO:0032489	regulation of Cdc42 protein signal transduction(GO:0032489)
0.0	0.1	GO:0070940	dephosphorylation of RNA polymerase II C-terminal domain(GO:0070940)
0.0	0.0	GO:0010025	wax biosynthetic process(GO:0010025) wax metabolic process(GO:0010166)
0.0	0.1	GO:0060267	positive regulation of respiratory burst(GO:0060267)
0.0	0.0	GO:2000646	positive regulation of receptor catabolic process(GO:2000646)
0.0	0.1	GO:0001547	antral ovarian follicle growth(GO:0001547)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.5	GO:0071204	histone pre-mRNA 3'end processing complex(GO:0071204)
0.1	0.2	GO:0000811	GINS complex(GO:0000811)
0.0	0.2	GO:0005726	perichromatin fibrils(GO:0005726)
0.0	0.1	GO:0005896	interleukin-6 receptor complex(GO:0005896)
0.0	0.1	GO:0035355	Toll-like receptor 2-Toll-like receptor 6 protein complex(GO:0035355)
0.0	0.1	GO:0070545	PeBoW complex(GO:0070545)
0.0	0.3	GO:0032045	guanyl-nucleotide exchange factor complex(GO:0032045)
0.0	0.1	GO:0044462	cell outer membrane(GO:0009279) cell envelope(GO:0030313) external encapsulating structure part(GO:0044462)
0.0	0.3	GO:0030126	COPI vesicle coat(GO:0030126)
0.0	0.1	GO:1990111	spermatoproteasome complex(GO:1990111)
0.0	0.1	GO:0042382	paraspeckles(GO:0042382)
0.0	0.1	GO:0032937	SREBP-SCAP-Insig complex(GO:0032937)
0.0	0.1	GO:0045098	type III intermediate filament(GO:0045098)
0.0	0.1	GO:0005899	insulin receptor complex(GO:0005899)
0.0	0.2	GO:0097431	mitotic spindle pole(GO:0097431)
0.0	0.1	GO:0045293	mRNA editing complex(GO:0045293)
0.0	0.0	GO:0071942	XPC complex(GO:0071942)
0.0	0.1	GO:0031618	nuclear pericentric heterochromatin(GO:0031618)
0.0	0.0	GO:0016939	kinesin II complex(GO:0016939)
0.0	0.3	GO:0030686	90S preribosome(GO:0030686)
0.0	0.1	GO:0005952	cAMP-dependent protein kinase complex(GO:0005952)
0.0	0.0	GO:0005712	chiasma(GO:0005712)
0.0	0.0	GO:0061689	tricellular tight junction(GO:0061689)
0.0	0.1	GO:0043202	lysosomal lumen(GO:0043202)
0.0	0.1	GO:0005638	lamin filament(GO:0005638)
0.0	0.0	GO:0016222	procollagen-proline 4-dioxygenase complex(GO:0016222)
0.0	0.3	GO:0005720	nuclear heterochromatin(GO:0005720)
0.0	0.1	GO:0005577	fibrinogen complex(GO:0005577)
0.0	0.1	GO:1990124	messenger ribonucleoprotein complex(GO:1990124)
0.0	0.2	GO:0035327	transcriptionally active chromatin(GO:0035327)
0.0	0.0	GO:0034448	EGO complex(GO:0034448) Gtr1-Gtr2 GTPase complex(GO:1990131)
0.0	0.1	GO:0033063	Rad51B-Rad51C-Rad51D-XRCC2 complex(GO:0033063)
0.0	0.2	GO:0000159	protein phosphatase type 2A complex(GO:0000159)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:0042392	sphingosine-1-phosphate phosphatase activity(GO:0042392)
0.1	0.3	GO:0034056	estrogen response element binding(GO:0034056)
0.1	0.3	GO:0032896	palmitoyl-CoA 9-desaturase activity(GO:0032896)
0.1	0.2	GO:0004104	cholinesterase activity(GO:0004104)
0.0	0.2	GO:0008970	phosphatidylcholine 1-acylhydrolase activity(GO:0008970)
0.0	0.1	GO:0055100	adiponectin binding(GO:0055100)
0.0	0.4	GO:0004499	N,N-dimethylaniline monooxygenase activity(GO:0004499)
0.0	0.1	GO:0004924	oncostatin-M receptor activity(GO:0004924)
0.0	0.1	GO:0035663	Toll-like receptor 2 binding(GO:0035663)
0.0	0.1	GO:0004616	phosphogluconate dehydrogenase (decarboxylating) activity(GO:0004616)
0.0	0.2	GO:0019784	NEDD8-specific protease activity(GO:0019784)
0.0	0.3	GO:0034711	inhibin binding(GO:0034711)
0.0	0.3	GO:0004445	inositol-polyphosphate 5-phosphatase activity(GO:0004445)
0.0	0.1	GO:0001069	regulatory region RNA binding(GO:0001069)
0.0	0.1	GO:0015183	L-aspartate transmembrane transporter activity(GO:0015183)
0.0	0.1	GO:0071209	U7 snRNA binding(GO:0071209)
0.0	0.2	GO:0019871	sodium channel inhibitor activity(GO:0019871)
0.0	0.1	GO:0004332	fructose-bisphosphate aldolase activity(GO:0004332)
0.0	0.1	GO:0046923	ER retention sequence binding(GO:0046923)
0.0	0.1	GO:0008508	bile acid:sodium symporter activity(GO:0008508)
0.0	0.1	GO:0016743	carboxyl- or carbamoyltransferase activity(GO:0016743)
0.0	0.1	GO:0033142	progesterone receptor binding(GO:0033142)
0.0	0.1	GO:0004691	cAMP-dependent protein kinase activity(GO:0004691)
0.0	0.1	GO:0070290	N-acylphosphatidylethanolamine-specific phospholipase D activity(GO:0070290)
0.0	0.3	GO:0005542	folic acid binding(GO:0005542)
0.0	0.2	GO:1990405	protein antigen binding(GO:1990405)
0.0	0.5	GO:0036002	pre-mRNA binding(GO:0036002)
0.0	0.1	GO:1990239	steroid hormone binding(GO:1990239)
0.0	0.1	GO:0052650	NADP-retinol dehydrogenase activity(GO:0052650)
0.0	0.1	GO:0005047	signal recognition particle binding(GO:0005047)
0.0	0.1	GO:0047623	AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.0	0.1	GO:0043423	3-phosphoinositide-dependent protein kinase binding(GO:0043423)
0.0	0.1	GO:0001602	pancreatic polypeptide receptor activity(GO:0001602)
0.0	0.1	GO:0004301	epoxide hydrolase activity(GO:0004301)
0.0	0.2	GO:0001206	transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206)
0.0	0.0	GO:0008898	S-adenosylmethionine-homocysteine S-methyltransferase activity(GO:0008898)
0.0	0.1	GO:0102391	decanoate--CoA ligase activity(GO:0102391)
0.0	0.1	GO:0004366	glycerol-3-phosphate O-acyltransferase activity(GO:0004366)
0.0	0.1	GO:0034875	oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor(GO:0033695) caffeine oxidase activity(GO:0034875)
0.0	0.1	GO:0097322	7SK snRNA binding(GO:0097322)
0.0	0.0	GO:0004886	9-cis retinoic acid receptor activity(GO:0004886)
0.0	0.1	GO:0016668	oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor(GO:0016668)
0.0	0.1	GO:0008532	N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity(GO:0008532)
0.0	0.1	GO:0035671	enone reductase activity(GO:0035671)
0.0	0.0	GO:0016822	hydrolase activity, acting on acid carbon-carbon bonds(GO:0016822) hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances(GO:0016823)
0.0	0.1	GO:0051959	dynein light intermediate chain binding(GO:0051959)
0.0	0.1	GO:0051525	NFAT protein binding(GO:0051525)
0.0	0.1	GO:0048406	nerve growth factor binding(GO:0048406)
0.0	0.2	GO:0008601	protein phosphatase type 2A regulator activity(GO:0008601)
0.0	0.0	GO:0016971	flavin-linked sulfhydryl oxidase activity(GO:0016971)
0.0	0.1	GO:0004064	arylesterase activity(GO:0004064)
0.0	0.0	GO:0004594	pantothenate kinase activity(GO:0004594)
0.0	0.2	GO:0008266	poly(U) RNA binding(GO:0008266)
0.0	0.0	GO:0004046	aminoacylase activity(GO:0004046)
0.0	0.1	GO:0004758	serine C-palmitoyltransferase activity(GO:0004758)
0.0	0.1	GO:0051864	histone demethylase activity (H3-K36 specific)(GO:0051864)
0.0	0.1	GO:0004017	adenylate kinase activity(GO:0004017)
0.0	0.1	GO:0004028	3-chloroallyl aldehyde dehydrogenase activity(GO:0004028)
0.0	0.2	GO:0070577	lysine-acetylated histone binding(GO:0070577)
0.0	0.1	GO:0005375	copper ion transmembrane transporter activity(GO:0005375)
0.0	0.0	GO:0032139	dinucleotide insertion or deletion binding(GO:0032139)
0.0	0.3	GO:0044688	calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117) cGMP-stimulated cyclic-nucleotide phosphodiesterase activity(GO:0004118) cGMP-inhibited cyclic-nucleotide phosphodiesterase activity(GO:0004119) photoreceptor cyclic-nucleotide phosphodiesterase activity(GO:0004120) 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate phosphodiesterase activity(GO:0044688) inositol phosphosphingolipid phospholipase activity(GO:0052712) inositol phosphorylceramide phospholipase activity(GO:0052713) mannosyl-inositol phosphorylceramide phospholipase activity(GO:0052714) mannosyl-diinositol phosphorylceramide phospholipase activity(GO:0052715)
0.0	0.1	GO:0046790	virion binding(GO:0046790)
0.0	0.0	GO:0019237	centromeric DNA binding(GO:0019237)
0.0	0.2	GO:0004602	glutathione peroxidase activity(GO:0004602)
0.0	0.1	GO:0008499	UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity(GO:0008499)

Gene overrepresentation in curated gene sets: canonical pathways category:

Total log-likelihood	Term	Description
0.0	PID MAPK TRK PATHWAY	Trk receptor signaling mediated by the MAPK pathway
0.3	PID S1P META PATHWAY	Sphingosine 1-phosphate (S1P) pathway
0.2	PID ARF6 DOWNSTREAM PATHWAY	Arf6 downstream pathway
0.3	PID EPHA2 FWD PATHWAY	EPHA2 forward signaling
0.3	PID ALK1 PATHWAY	ALK1 signaling events
0.1	SA G1 AND S PHASES	Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
0.5	PID AR TF PATHWAY	Regulation of Androgen receptor activity

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Total log-likelihood	Term	Description
0.4	REACTOME SIGNALING BY NODAL	Genes involved in Signaling by NODAL
0.2	REACTOME SYNTHESIS OF PE	Genes involved in Synthesis of PE
0.2	REACTOME ALPHA LINOLENIC ACID ALA METABOLISM	Genes involved in alpha-linolenic acid (ALA) metabolism
0.6	REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS	Genes involved in Sphingolipid de novo biosynthesis
0.2	REACTOME RECYCLING OF BILE ACIDS AND SALTS	Genes involved in Recycling of bile acids and salts
0.1	REACTOME BETA DEFENSINS	Genes involved in Beta defensins
0.1	REACTOME SHC RELATED EVENTS	Genes involved in SHC-related events
0.2	REACTOME CDC6 ASSOCIATION WITH THE ORC ORIGIN COMPLEX	Genes involved in CDC6 association with the ORC:origin complex
0.2	REACTOME UNWINDING OF DNA	Genes involved in Unwinding of DNA
0.1	REACTOME IL 6 SIGNALING	Genes involved in Interleukin-6 signaling
0.2	REACTOME SIGNALING BY FGFR1 FUSION MUTANTS	Genes involved in Signaling by FGFR1 fusion mutants
0.2	REACTOME PLATELET SENSITIZATION BY LDL	Genes involved in Platelet sensitization by LDL
0.2	REACTOME SHC1 EVENTS IN ERBB4 SIGNALING	Genes involved in SHC1 events in ERBB4 signaling
0.3	REACTOME IL RECEPTOR SHC SIGNALING	Genes involved in Interleukin receptor SHC signaling
0.0	REACTOME AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1	Genes involved in Autodegradation of the E3 ubiquitin ligase COP1
0.1	REACTOME ABACAVIR TRANSPORT AND METABOLISM	Genes involved in Abacavir transport and metabolism
0.2	REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT	Genes involved in Chylomicron-mediated lipid transport
0.1	REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA HYDROXYCHOLESTEROL	Genes involved in Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
0.2	REACTOME RAP1 SIGNALLING	Genes involved in Rap1 signalling
0.0	REACTOME BILE ACID AND BILE SALT METABOLISM	Genes involved in Bile acid and bile salt metabolism
0.0	REACTOME DCC MEDIATED ATTRACTIVE SIGNALING	Genes involved in DCC mediated attractive signaling