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ENCSR904DTN: DNase-seq of mouse liver in constant darkness

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Results for Pknox2_Pknox1

Z-value: 0.95

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Transcription factors associated with Pknox2_Pknox1

Gene Symbol	Gene ID	Gene Info
Pknox2 Ensembl NCBI MGI UniProt	ENSMUSG00000035934.9	Pbx/knotted 1 homeobox 2
Pknox1 Ensembl NCBI MGI UniProt	ENSMUSG00000006705.6	Pbx/knotted 1 homeobox

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
chr17_31607362_31607553	Pknox1	4719	0.101046	0.91	1.1e-02	Click!
chr17_31607662_31607820	Pknox1	5003	0.099351	0.79	6.4e-02	Click!
chr17_31608379_31608531	Pknox1	5717	0.096085	0.59	2.1e-01	Click!
chr17_31564751_31564906	Pknox1	12	0.695950	0.58	2.2e-01	Click!
chr17_31607121_31607285	Pknox1	4465	0.102826	0.40	4.3e-01	Click!
chr9_37147174_37147330	Pknox2	14	0.964661	0.81	4.9e-02	Click!
chr9_36933794_36933960	Pknox2	53395	0.099241	-0.77	7.5e-02	Click!
chr9_36991937_36992116	Pknox2	4754	0.192169	0.71	1.2e-01	Click!
chr9_37146676_37146845	Pknox2	506	0.701499	0.70	1.2e-01	Click!
chr9_37146437_37146602	Pknox2	704	0.570203	0.62	1.9e-01	Click!

Activity of the Pknox2_Pknox1 motif across conditions

Conditions sorted by the z-value of the Pknox2_Pknox1 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr1_180219669_180219845	0.72	Gm37336	predicted gene, 37336	7356	0.14
chr10_119010707_119010858	0.63	Gm47461	predicted gene, 47461	10888	0.17
chr12_21166146_21166319	0.60	Asap2	ArfGAP with SH3 domain, ankyrin repeat and PH domain 2	54278	0.1
chr6_121860064_121860215	0.53	Mug1	murinoglobulin 1	19035	0.19
chr4_60659551_60660018	0.50	Mup11	major urinary protein 11	46	0.97
chr9_69306275_69306692	0.50	Rora	RAR-related orphan receptor alpha	16801	0.21
chr12_40475800_40475951	0.47	Dock4	dedicator of cytokinesis 4	29539	0.19
chr2_19647255_19647467	0.47	Gm13343	predicted gene 13343	4987	0.15
chr15_31058451_31058629	0.43	4930430F21Rik	RIKEN cDNA 4930430F21 gene	19412	0.2
chr1_93146606_93146776	0.43	Agxt	alanine-glyoxylate aminotransferase	6812	0.13
chr4_33245665_33245911	0.43	Pnrc1	proline-rich nuclear receptor coactivator 1	1787	0.31
chr18_46717220_46717635	0.42	Cdo1	cysteine dioxygenase 1, cytosolic	10602	0.13
chr12_109993740_109993939	0.40	Gm34667	predicted gene, 34667	30034	0.1
chr12_12405687_12405864	0.40	4921511I17Rik	RIKEN cDNA 4921511I17 gene	13160	0.28
chr10_78294277_78294441	0.40	Agpat3	1-acylglycerol-3-phosphate O-acyltransferase 3	1035	0.32
chr1_191493887_191494044	0.39	Gm37432	predicted gene, 37432	60	0.96
chr7_113223800_113224075	0.39	Arntl	aryl hydrocarbon receptor nuclear translocator-like	10686	0.21
chr9_50875623_50875774	0.38	Ppp2r1b	protein phosphatase 2, regulatory subunit A, beta	2387	0.25
chr19_23060777_23060935	0.37	Gm50136	predicted gene, 50136	598	0.75
chr19_36627452_36627789	0.37	Hectd2os	Hectd2, opposite strand	1596	0.43
chr17_56211204_56211384	0.36	Dpp9	dipeptidylpeptidase 9	2086	0.16
chr9_48739409_48739562	0.36	Zbtb16	zinc finger and BTB domain containing 16	96460	0.07
chr10_63410268_63410432	0.36	Gm7530	predicted gene 7530	2649	0.19
chr1_93687795_93687979	0.35	Bok	BCL2-related ovarian killer	1321	0.35
chr10_43709388_43709808	0.35	F930017D23Rik	RIKEN cDNA F930017D23 gene	2700	0.18
chr13_93632435_93632697	0.34	Bhmt	betaine-homocysteine methyltransferase	5000	0.17
chr16_35727863_35728078	0.34	Gm25967	predicted gene, 25967	5737	0.18
chr9_40638323_40638501	0.34	Gm48284	predicted gene, 48284	22026	0.1
chr5_114553798_114553965	0.33	Gm13790	predicted gene 13790	2592	0.24
chr16_16225035_16225410	0.33	Pkp2	plakophilin 2	11904	0.19
chr14_21719739_21719901	0.33	Dupd1	dual specificity phosphatase and pro isomerase domain containing 1	5244	0.17
chr5_114553572_114553723	0.33	Gm13790	predicted gene 13790	2358	0.25
chr11_46312714_46312865	0.32	Cyfip2	cytoplasmic FMR1 interacting protein 2	70	0.97
chr1_190044023_190044190	0.31	Smyd2	SET and MYND domain containing 2	121743	0.05
chr15_67420967_67421299	0.31	1700012I11Rik	RIKEN cDNA 1700012I11 gene	194364	0.03
chr16_94693543_94693992	0.31	Gm41504	predicted gene, 41504	20136	0.16
chr15_80680125_80680365	0.30	Fam83f	family with sequence similarity 83, member F	8398	0.13
chr11_102753302_102753453	0.30	Adam11	a disintegrin and metallopeptidase domain 11	8062	0.11
chr9_66154137_66154300	0.29	Dapk2	death-associated protein kinase 2	4005	0.21
chr5_130761960_130762123	0.29	Gm23761	predicted gene, 23761	20660	0.24
chr16_93728444_93728595	0.29	Dop1b	DOP1 leucine zipper like protein B	1580	0.35
chr13_112071667_112072207	0.28	Gm31104	predicted gene, 31104	66179	0.09
chr2_164054518_164054669	0.28	Pabpc1l	poly(A) binding protein, cytoplasmic 1-like	6583	0.14
chr3_132887148_132887306	0.28	Gm29811	predicted gene, 29811	8631	0.16
chr4_107002621_107002790	0.28	Gm12786	predicted gene 12786	19794	0.15
chr9_70931148_70931345	0.27	Gm32017	predicted gene, 32017	758	0.66
chr19_36484338_36484507	0.27	F530104D19Rik	RIKEN cDNA F530104D19 gene	33265	0.15
chr8_119428106_119428304	0.27	Osgin1	oxidative stress induced growth inhibitor 1	5919	0.16
chr1_121304990_121305141	0.26	Insig2	insulin induced gene 2	2253	0.26
chr15_37456125_37456321	0.26	Ncald	neurocalcin delta	2318	0.22
chr3_83043842_83044694	0.26	Fgb	fibrinogen beta chain	5595	0.15
chr3_8891989_8892146	0.26	Gm15466	predicted gene 15466	9497	0.17
chr7_79493997_79494159	0.26	Mir9-3hg	Mir9-3 host gene	5948	0.1
chr4_137481328_137481504	0.26	Hspg2	perlecan (heparan sulfate proteoglycan 2)	12613	0.13
chr15_102192070_102192387	0.25	Csad	cysteine sulfinic acid decarboxylase	169	0.91
chr4_45285469_45285620	0.25	Trmt10b	tRNA methyltransferase 10B	11583	0.15
chr10_8089529_8089695	0.25	Gm48614	predicted gene, 48614	68320	0.11
chr8_48729447_48729608	0.25	Tenm3	teneurin transmembrane protein 3	54837	0.15
chr15_36471981_36472313	0.25	Ankrd46	ankyrin repeat domain 46	24568	0.12
chr3_81956990_81957439	0.24	Ctso	cathepsin O	6277	0.16
chr11_58003210_58003371	0.24	Larp1	La ribonucleoprotein domain family, member 1	5774	0.17
chr4_61436878_61437320	0.24	Mup15	major urinary protein 15	2644	0.27
chr7_125577330_125577481	0.24	Gm44876	predicted gene 44876	5288	0.17
chr11_46579639_46579790	0.24	BC053393	cDNA sequence BC053393	8178	0.13
chr19_3840335_3840486	0.24	Chka	choline kinase alpha	11363	0.09
chr3_104796399_104796698	0.23	Rhoc	ras homolog family member C	4565	0.1
chr5_114982798_114982985	0.23	1810017P11Rik	RIKEN cDNA 1810017P11 gene	7435	0.09
chr15_78231969_78232141	0.23	Ncf4	neutrophil cytosolic factor 4	12746	0.13
chr6_91686720_91686890	0.23	Slc6a6	solute carrier family 6 (neurotransmitter transporter, taurine), member 6	2656	0.18
chr9_20504907_20505058	0.23	Zfp426	zinc finger protein 426	12236	0.11
chr10_34298110_34298293	0.23	Gm47512	predicted gene, 47512	613	0.44
chr3_50443598_50443859	0.22	Slc7a11	solute carrier family 7 (cationic amino acid transporter, y+ system), member 11	114	0.97
chr19_61049084_61049293	0.22	Gm22520	predicted gene, 22520	35643	0.14
chr10_86069565_86069729	0.22	Syn3	synapsin III	2804	0.18
chr17_84895942_84896103	0.22	Gm49982	predicted gene, 49982	6547	0.18
chr8_86933808_86934280	0.22	Gm27168	predicted gene 27168	12897	0.13
chr9_74868478_74868651	0.22	Onecut1	one cut domain, family member 1	2080	0.26
chr1_179844970_179845129	0.22	Ahctf1	AT hook containing transcription factor 1	41369	0.14
chr7_114203119_114203440	0.22	Gm45454	predicted gene 45454	5809	0.22
chr3_60057385_60057653	0.22	Sucnr1	succinate receptor 1	24350	0.14
chr17_13699350_13699759	0.22	Gm16046	predicted gene 16046	16038	0.13
chr6_93153422_93153582	0.22	Gm5313	predicted gene 5313	15512	0.21
chr4_61779591_61780024	0.22	Mup19	major urinary protein 19	2417	0.19
chr17_64609042_64609223	0.22	Man2a1	mannosidase 2, alpha 1	8396	0.26
chr9_65322219_65322370	0.22	Gm39363	predicted gene, 39363	10226	0.09
chr14_66672460_66672626	0.22	Adra1a	adrenergic receptor, alpha 1a	36987	0.17
chr9_119143465_119143650	0.22	Acaa1b	acetyl-Coenzyme A acyltransferase 1B	6506	0.12
chr9_63042658_63043014	0.22	Gm24526	predicted gene, 24526	15276	0.18
chr4_61671437_61671659	0.22	Mup18	major urinary protein 18	2588	0.25
chr2_101903298_101903465	0.22	Commd9	COMM domain containing 9	17118	0.18
chr1_5071962_5072114	0.22	Rgs20	regulator of G-protein signaling 20	1753	0.28
chr19_12486979_12487160	0.21	Dtx4	deltex 4, E3 ubiquitin ligase	14385	0.1
chr17_50489431_50489587	0.21	Plcl2	phospholipase C-like 2	19894	0.26
chr15_102186991_102187189	0.21	Csad	cysteine sulfinic acid decarboxylase	509	0.65
chr7_48881274_48881434	0.21	Gm2788	predicted gene 2788	54	0.74
chr4_19681355_19681795	0.21	Wwp1	WW domain containing E3 ubiquitin protein ligase 1	3127	0.29
chr10_83112464_83112627	0.21	1700025N21Rik	RIKEN cDNA 1700025N21 gene	29493	0.17
chr19_25542114_25542287	0.21	Dmrt1	doublesex and mab-3 related transcription factor 1	36493	0.15
chr2_116065184_116065343	0.21	Meis2	Meis homeobox 2	216	0.9
chr9_111100529_111100680	0.21	Lrrfip2	leucine rich repeat (in FLII) interacting protein 2	16988	0.12
chr19_47222639_47222810	0.21	Gm50339	predicted gene, 50339	815	0.48
chr8_117700284_117700470	0.20	Hsd17b2	hydroxysteroid (17-beta) dehydrogenase 2	1527	0.3
chr11_76709264_76709415	0.20	Trarg1	trafficking regulator of GLUT4 (SLC2A4) 1	29531	0.14
chr2_132577301_132577957	0.20	Gpcpd1	glycerophosphocholine phosphodiesterase 1	504	0.77
chr6_94550696_94550886	0.20	Slc25a26	solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 26	16651	0.2
chr2_122944888_122945077	0.20	Sqor	sulfide quinone oxidoreductase	145220	0.04
chr15_86177571_86177722	0.20	Gm15569	predicted gene 15569	8082	0.17
chr1_37300588_37300990	0.19	Inpp4a	inositol polyphosphate-4-phosphatase, type I	481	0.66
chr2_169750622_169750798	0.19	Tshz2	teashirt zinc finger family member 2	117034	0.06
chr9_96977502_96977653	0.19	Spsb4	splA/ryanodine receptor domain and SOCS box containing 4	5602	0.18
chr8_126806262_126806425	0.19	A630001O12Rik	RIKEN cDNA A630001O12 gene	32890	0.16
chr5_66798803_66798961	0.19	Limch1	LIM and calponin homology domains 1	52993	0.11
chr9_100446507_100446671	0.19	Gm28166	predicted gene 28166	3733	0.19
chr8_119436291_119436442	0.19	Osgin1	oxidative stress induced growth inhibitor 1	752	0.59
chr3_81062807_81062975	0.19	Gm16000	predicted gene 16000	22454	0.16
chr8_10965649_10965912	0.19	Gm44956	predicted gene 44956	5034	0.13
chr5_100860430_100860646	0.19	4930458D05Rik	RIKEN cDNA 4930458D05 gene	13371	0.1
chr3_85821665_85821854	0.19	Fam160a1	family with sequence similarity 160, member A1	4468	0.2
chr18_46627491_46627728	0.19	Gm3734	predicted gene 3734	3198	0.2
chr19_36534453_36534632	0.19	Hectd2	HECT domain E3 ubiquitin protein ligase 2	20097	0.2
chr2_6126122_6126290	0.19	Proser2	proline and serine rich 2	3933	0.18
chr19_47410387_47410546	0.19	Sh3pxd2a	SH3 and PX domains 2A	107	0.97
chr1_171196191_171196374	0.19	Pcp4l1	Purkinje cell protein 4-like 1	14	0.94
chr14_22800645_22800832	0.19	Gm7473	predicted gene 7473	25494	0.25
chr4_60067672_60068037	0.19	Mup7	major urinary protein 7	2557	0.26
chr2_32389286_32389437	0.19	Lcn2	lipocalin 2	1109	0.29
chr9_66331624_66331801	0.18	Herc1	HECT and RLD domain containing E3 ubiquitin protein ligase family member 1	18738	0.18
chr15_99867784_99867962	0.18	Lima1	LIM domain and actin binding 1	6798	0.08
chr1_67038526_67038707	0.18	Lancl1	LanC (bacterial lantibiotic synthetase component C)-like 1	218	0.94
chr6_122598952_122599267	0.18	Apobec1	apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1	1018	0.37
chr15_86202799_86202950	0.18	Gm22818	predicted gene, 22818	9783	0.16
chr4_144961736_144961902	0.18	Gm38074	predicted gene, 38074	2971	0.26
chr4_149794929_149795189	0.18	Gm13065	predicted gene 13065	1640	0.21
chr1_93124444_93124635	0.18	Gm28086	predicted gene 28086	436	0.76
chr8_117736689_117736847	0.18	Gm31774	predicted gene, 31774	11492	0.14
chr19_36731141_36731447	0.18	Ppp1r3c	protein phosphatase 1, regulatory subunit 3C	5359	0.23
chr2_28525746_28525944	0.18	Ralgds	ral guanine nucleotide dissociation stimulator	2005	0.19
chr2_167982734_167983076	0.18	Ripor3	RIPOR family member 3	3850	0.2
chr5_103591965_103592170	0.18	Gm15844	predicted gene 15844	32404	0.12
chr4_62778005_62778291	0.18	Gm24117	predicted gene, 24117	34280	0.14
chr11_83852040_83852214	0.18	Hnf1b	HNF1 homeobox B	115	0.95
chr18_68005512_68005663	0.18	Ldlrad4	low density lipoprotein receptor class A domain containing 4	72330	0.09
chr1_132170141_132170558	0.18	Lemd1	LEM domain containing 1	21082	0.1
chr10_86092029_86092180	0.18	4930486F22Rik	RIKEN cDNA 4930486F22 gene	3755	0.17
chr8_60631719_60632037	0.18	Gm34730	predicted gene, 34730	853	0.44
chr17_35251426_35251588	0.18	Mir8094	microRNA 8094	218	0.76
chr4_60137209_60137437	0.17	Mup2	major urinary protein 2	2534	0.26
chr4_97988281_97988451	0.17	Nfia	nuclear factor I/A	77333	0.11
chrX_36874176_36874336	0.17	Ube2a	ubiquitin-conjugating enzyme E2A	39	0.63
chr10_76032130_76032292	0.17	Zfp280b	zinc finger protein 280B	439	0.73
chr2_43678933_43679111	0.17	Kynu	kynureninase	8092	0.3
chr5_130853198_130853625	0.17	Gm42894	predicted gene 42894	14426	0.22
chr8_101351773_101352122	0.17	Gm22223	predicted gene, 22223	187761	0.03
chr3_27788248_27788425	0.17	Fndc3b	fibronectin type III domain containing 3B	77029	0.1
chr8_21778650_21778989	0.17	Defb1	defensin beta 1	2220	0.16
chr4_118132141_118132338	0.17	St3gal3	ST3 beta-galactoside alpha-2,3-sialyltransferase 3	2643	0.23
chr16_23106926_23107120	0.17	Eif4a2	eukaryotic translation initiation factor 4A2	421	0.55
chr8_33881292_33881487	0.17	Gm26978	predicted gene, 26978	4358	0.2
chr2_163494018_163494324	0.17	R3hdml	R3H domain containing-like	1853	0.21
chr11_78496004_78496169	0.17	Sarm1	sterile alpha and HEAT/Armadillo motif containing 1	1372	0.2
chr11_78417415_78417566	0.17	Slc13a2	solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2	4727	0.11
chr13_45906518_45907031	0.17	4930453C13Rik	RIKEN cDNA 4930453C13 gene	29266	0.18
chr16_57168528_57168697	0.16	Gm16892	predicted gene, 16892	1211	0.31
chr7_141949547_141949705	0.16	Gm20501	predicted gene 20501	87	0.55
chr5_5211241_5211412	0.16	Cdk14	cyclin-dependent kinase 14	15971	0.18
chr3_51560826_51560999	0.16	Setd7	SET domain containing (lysine methyltransferase) 7	33	0.92
chr15_55224563_55224882	0.16	Gm26296	predicted gene, 26296	37881	0.16
chr19_57535215_57535466	0.16	Gm50279	predicted gene, 50279	5443	0.15
chr2_30957612_30957790	0.16	Tor1b	torsin family 1, member B	2448	0.18
chr19_42196519_42196698	0.16	Sfrp5	secreted frizzled-related sequence protein 5	5644	0.14
chr6_121892053_121892211	0.16	Mug1	murinoglobulin 1	6555	0.19
chr10_77064998_77065227	0.16	Col18a1	collagen, type XVIII, alpha 1	5115	0.17
chrX_102478577_102478728	0.16	Hdac8	histone deacetylase 8	26089	0.19
chr9_108794998_108795174	0.16	Gm23034	predicted gene, 23034	302	0.72
chr17_29053774_29054133	0.16	Gm41556	predicted gene, 41556	154	0.9
chr7_30353715_30354115	0.16	4930479H17Rik	RIKEN cDNA 4930479H17 gene	594	0.46
chr8_117306309_117306592	0.16	Cmip	c-Maf inducing protein	42720	0.17
chr10_115777494_115777663	0.16	Tspan8	tetraspanin 8	39254	0.19
chr11_90258619_90258781	0.16	Mmd	monocyte to macrophage differentiation-associated	9224	0.22
chr4_60818855_60819228	0.16	Mup22	major urinary protein 22	2422	0.29
chr16_10952104_10952327	0.15	Gm26268	predicted gene, 26268	13509	0.11
chr5_145984724_145985158	0.15	Cyp3a25	cytochrome P450, family 3, subfamily a, polypeptide 25	6702	0.13
chr12_104818327_104818478	0.15	Clmn	calmin	37531	0.14
chr10_99599315_99599605	0.15	Gm20110	predicted gene, 20110	9711	0.18
chr15_100659832_100659991	0.15	Bin2	bridging integrator 2	8251	0.09
chr7_141475336_141475516	0.15	Tspan4	tetraspanin 4	84	0.73
chr1_39105102_39105502	0.15	Gm37091	predicted gene, 37091	21964	0.17
chr10_127877485_127877659	0.15	Rdh7	retinol dehydrogenase 7	10758	0.09
chr8_10859650_10859809	0.15	Gm32540	predicted gene, 32540	6457	0.13
chr11_20831246_20831415	0.15	Lgalsl	lectin, galactoside binding-like	274	0.72
chr1_151679282_151679446	0.15	Fam129a	family with sequence similarity 129, member A	2197	0.35
chr14_29107334_29107489	0.15	Cacna2d3	calcium channel, voltage-dependent, alpha2/delta subunit 3	9508	0.21
chr5_43219459_43219610	0.15	Cpeb2	cytoplasmic polyadenylation element binding protein 2	13636	0.15
chr19_45745506_45745808	0.15	Fgf8	fibroblast growth factor 8	2742	0.18
chr19_34880110_34880491	0.15	Pank1	pantothenate kinase 1	845	0.59
chr15_36491785_36492199	0.15	Ankrd46	ankyrin repeat domain 46	4723	0.17
chr13_35018660_35018815	0.15	Eci2	enoyl-Coenzyme A delta isomerase 2	8357	0.12
chr19_55660221_55660414	0.15	Tcf7l2	transcription factor 7 like 2, T cell specific, HMG box	81503	0.11
chr14_41119395_41119820	0.15	Sftpa1	surfactant associated protein A1	12175	0.11
chr13_36577900_36578089	0.14	Gm48767	predicted gene, 48767	2060	0.25

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of Pknox2_Pknox1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	0.5	GO:0046439	cysteine catabolic process(GO:0009093) L-cysteine catabolic process(GO:0019448) L-cysteine metabolic process(GO:0046439)
0.1	0.3	GO:0072675	osteoclast fusion(GO:0072675)
0.0	0.2	GO:0089711	L-glutamate transmembrane transport(GO:0089711)
0.0	0.2	GO:0072180	mesonephric duct morphogenesis(GO:0072180)
0.0	0.1	GO:0030423	targeting of mRNA for destruction involved in RNA interference(GO:0030423)
0.0	0.1	GO:0035461	vitamin transmembrane transport(GO:0035461)
0.0	0.2	GO:1900122	positive regulation of receptor binding(GO:1900122)
0.0	0.1	GO:0060137	maternal process involved in parturition(GO:0060137)
0.0	0.1	GO:1904694	negative regulation of vascular smooth muscle contraction(GO:1904694)
0.0	0.1	GO:0072367	regulation of lipid transport by regulation of transcription from RNA polymerase II promoter(GO:0072367)
0.0	0.1	GO:2000418	positive regulation of eosinophil migration(GO:2000418)
0.0	0.1	GO:0009115	xanthine catabolic process(GO:0009115)
0.0	0.1	GO:0090310	negative regulation of methylation-dependent chromatin silencing(GO:0090310)
0.0	0.1	GO:1902730	regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010908) positive regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010909) positive regulation of proteoglycan biosynthetic process(GO:1902730)
0.0	0.1	GO:0097195	pilomotor reflex(GO:0097195)
0.0	0.1	GO:2001187	positive regulation of CD8-positive, alpha-beta T cell activation(GO:2001187)
0.0	0.1	GO:0019254	carnitine metabolic process, CoA-linked(GO:0019254)
0.0	0.1	GO:1902744	negative regulation of lamellipodium organization(GO:1902744)
0.0	0.1	GO:0043152	induction of bacterial agglutination(GO:0043152)
0.0	0.1	GO:0006046	N-acetylglucosamine catabolic process(GO:0006046)
0.0	0.1	GO:0006686	sphingomyelin biosynthetic process(GO:0006686)
0.0	0.2	GO:0018026	peptidyl-lysine monomethylation(GO:0018026)
0.0	0.1	GO:0044539	long-chain fatty acid import(GO:0044539)
0.0	0.1	GO:0086073	bundle of His cell-Purkinje myocyte adhesion involved in cell communication(GO:0086073)
0.0	0.1	GO:0042524	negative regulation of tyrosine phosphorylation of Stat5 protein(GO:0042524)
0.0	0.0	GO:0048320	axial mesoderm formation(GO:0048320)
0.0	0.0	GO:0051182	coenzyme transport(GO:0051182)
0.0	0.1	GO:0007220	Notch receptor processing(GO:0007220)
0.0	0.2	GO:0006577	amino-acid betaine metabolic process(GO:0006577)
0.0	0.1	GO:1900042	positive regulation of interleukin-2 secretion(GO:1900042)
0.0	0.1	GO:0046951	ketone body biosynthetic process(GO:0046951)
0.0	0.1	GO:0006703	estrogen biosynthetic process(GO:0006703)
0.0	0.0	GO:0001543	ovarian follicle rupture(GO:0001543)
0.0	0.1	GO:0097067	cellular response to thyroid hormone stimulus(GO:0097067)
0.0	0.0	GO:0007525	somatic muscle development(GO:0007525)
0.0	0.1	GO:0002317	plasma cell differentiation(GO:0002317)
0.0	0.1	GO:0051919	positive regulation of fibrinolysis(GO:0051919)
0.0	0.1	GO:0035331	negative regulation of hippo signaling(GO:0035331)
0.0	0.2	GO:0046475	glycerophospholipid catabolic process(GO:0046475)
0.0	0.0	GO:0060125	negative regulation of growth hormone secretion(GO:0060125)
0.0	0.1	GO:0060763	mammary duct terminal end bud growth(GO:0060763)
0.0	0.2	GO:0072673	lamellipodium morphogenesis(GO:0072673)
0.0	0.1	GO:1903887	motile primary cilium assembly(GO:1903887)
0.0	0.1	GO:0061635	regulation of protein complex stability(GO:0061635)
0.0	0.0	GO:0061341	non-canonical Wnt signaling pathway involved in heart development(GO:0061341) planar cell polarity pathway involved in heart morphogenesis(GO:0061346)
0.0	0.1	GO:0032463	negative regulation of protein homooligomerization(GO:0032463)
0.0	0.1	GO:0097368	establishment of Sertoli cell barrier(GO:0097368)
0.0	0.0	GO:1900060	negative regulation of ceramide biosynthetic process(GO:1900060)
0.0	0.1	GO:0036315	cellular response to sterol(GO:0036315)
0.0	0.1	GO:0006528	asparagine metabolic process(GO:0006528)
0.0	0.0	GO:0060800	regulation of cell differentiation involved in embryonic placenta development(GO:0060800)
0.0	0.0	GO:0006556	S-adenosylmethionine biosynthetic process(GO:0006556)
0.0	0.0	GO:0050923	regulation of negative chemotaxis(GO:0050923)
0.0	0.0	GO:0045963	negative regulation of catecholamine metabolic process(GO:0045914) negative regulation of dopamine metabolic process(GO:0045963)
0.0	0.0	GO:0060448	dichotomous subdivision of terminal units involved in lung branching(GO:0060448)
0.0	0.0	GO:2001286	regulation of caveolin-mediated endocytosis(GO:2001286)
0.0	0.0	GO:0051795	positive regulation of catagen(GO:0051795)
0.0	0.0	GO:1904395	regulation of skeletal muscle acetylcholine-gated channel clustering(GO:1904393) positive regulation of skeletal muscle acetylcholine-gated channel clustering(GO:1904395)
0.0	0.0	GO:0072566	chemokine (C-X-C motif) ligand 1 production(GO:0072566) regulation of chemokine (C-X-C motif) ligand 1 production(GO:2000338)
0.0	0.2	GO:2001241	positive regulation of extrinsic apoptotic signaling pathway in absence of ligand(GO:2001241)
0.0	0.1	GO:0015712	hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760)
0.0	0.0	GO:0060523	prostate epithelial cord elongation(GO:0060523)
0.0	0.1	GO:0051771	negative regulation of nitric-oxide synthase biosynthetic process(GO:0051771)
0.0	0.0	GO:0006933	negative regulation of cell adhesion involved in substrate-bound cell migration(GO:0006933)
0.0	0.0	GO:0070900	mitochondrial tRNA modification(GO:0070900) mitochondrial RNA modification(GO:1900864)
0.0	0.1	GO:0043518	negative regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043518)
0.0	0.1	GO:0006569	tryptophan catabolic process(GO:0006569) tryptophan catabolic process to kynurenine(GO:0019441) indole-containing compound catabolic process(GO:0042436) indolalkylamine catabolic process(GO:0046218)
0.0	0.0	GO:0090292	nuclear matrix organization(GO:0043578) nuclear matrix anchoring at nuclear membrane(GO:0090292)
0.0	0.0	GO:0061643	chemorepulsion of axon(GO:0061643)
0.0	0.0	GO:0023021	termination of signal transduction(GO:0023021)
0.0	0.0	GO:0033563	dorsal/ventral axon guidance(GO:0033563)
0.0	0.1	GO:1901678	iron coordination entity transport(GO:1901678)
0.0	0.0	GO:0052422	modulation of catalytic activity in other organism involved in symbiotic interaction(GO:0052203) modulation by host of symbiont catalytic activity(GO:0052422)
0.0	0.1	GO:0060363	cranial suture morphogenesis(GO:0060363)
0.0	0.1	GO:1900119	positive regulation of execution phase of apoptosis(GO:1900119)
0.0	0.0	GO:0071922	establishment of sister chromatid cohesion(GO:0034085) cohesin loading(GO:0071921) regulation of cohesin loading(GO:0071922)
0.0	0.1	GO:0002756	MyD88-independent toll-like receptor signaling pathway(GO:0002756)
0.0	0.0	GO:1990791	dorsal root ganglion development(GO:1990791)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.2	GO:0032937	SREBP-SCAP-Insig complex(GO:0032937)
0.0	0.1	GO:0033503	HULC complex(GO:0033503)
0.0	0.1	GO:0034274	Atg12-Atg5-Atg16 complex(GO:0034274)
0.0	0.1	GO:0070578	RISC-loading complex(GO:0070578)
0.0	0.1	GO:0044308	axonal spine(GO:0044308)
0.0	0.1	GO:0031209	SCAR complex(GO:0031209)
0.0	0.0	GO:0071664	catenin-TCF7L2 complex(GO:0071664)
0.0	0.1	GO:0005577	fibrinogen complex(GO:0005577)
0.0	0.0	GO:0033553	rDNA heterochromatin(GO:0033553)
0.0	0.1	GO:0051286	cell tip(GO:0051286)
0.0	0.1	GO:0031464	Cul4A-RING E3 ubiquitin ligase complex(GO:0031464)
0.0	0.0	GO:0044462	cell outer membrane(GO:0009279) cell envelope(GO:0030313) external encapsulating structure part(GO:0044462)
0.0	0.1	GO:0016461	unconventional myosin complex(GO:0016461)
0.0	0.1	GO:0005688	U6 snRNP(GO:0005688)
0.0	0.0	GO:0035339	SPOTS complex(GO:0035339)
0.0	0.0	GO:0005899	insulin receptor complex(GO:0005899)

Gene overrepresentation in molecular function category:

Total log-likelihood	Term	Description
0.2	GO:0005294	neutral L-amino acid secondary active transmembrane transporter activity(GO:0005294)
0.1	GO:0008142	oxysterol binding(GO:0008142)
0.1	GO:0008898	S-adenosylmethionine-homocysteine S-methyltransferase activity(GO:0008898)
0.2	GO:0016176	superoxide-generating NADPH oxidase activator activity(GO:0016176)
0.1	GO:0070883	pre-miRNA binding(GO:0070883)
0.2	GO:0047035	testosterone dehydrogenase (NAD+) activity(GO:0047035)
0.1	GO:0004854	xanthine dehydrogenase activity(GO:0004854) oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor(GO:0016726)
0.1	GO:2001070	starch binding(GO:2001070)
0.1	GO:0050220	prostaglandin-E synthase activity(GO:0050220)
0.1	GO:0017162	aryl hydrocarbon receptor binding(GO:0017162)
0.2	GO:0046790	virion binding(GO:0046790)
0.1	GO:0016823	hydrolase activity, acting on acid carbon-carbon bonds(GO:0016822) hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances(GO:0016823)
0.1	GO:0004126	cytidine deaminase activity(GO:0004126)
0.1	GO:0004663	Rab geranylgeranyltransferase activity(GO:0004663)
0.1	GO:0001875	lipopolysaccharide receptor activity(GO:0001875)
0.1	GO:0004095	carnitine O-palmitoyltransferase activity(GO:0004095)
0.1	GO:0004985	opioid receptor activity(GO:0004985)
0.1	GO:0015526	hexose phosphate transmembrane transporter activity(GO:0015119) organophosphate:inorganic phosphate antiporter activity(GO:0015315) hexose-phosphate:inorganic phosphate antiporter activity(GO:0015526) glucose 6-phosphate:inorganic phosphate antiporter activity(GO:0061513)
0.2	GO:0042500	aspartic endopeptidase activity, intramembrane cleaving(GO:0042500)
0.1	GO:0019776	Atg8 ligase activity(GO:0019776)
0.1	GO:0004438	phosphatidylinositol-3-phosphatase activity(GO:0004438)
0.1	GO:0003997	acyl-CoA oxidase activity(GO:0003997)
0.0	GO:0004937	alpha1-adrenergic receptor activity(GO:0004937)
0.2	GO:0050811	GABA receptor binding(GO:0050811)
0.0	GO:1990460	leptin receptor binding(GO:1990460)
0.5	GO:0016831	carboxy-lyase activity(GO:0016831)
0.2	GO:0008601	protein phosphatase type 2A regulator activity(GO:0008601)
0.1	GO:0004594	pantothenate kinase activity(GO:0004594)
0.0	GO:0016833	oxo-acid-lyase activity(GO:0016833)
0.0	GO:0046979	TAP1 binding(GO:0046978) TAP2 binding(GO:0046979)
0.0	GO:0004104	cholinesterase activity(GO:0004104)
0.0	GO:0043398	HLH domain binding(GO:0043398)
0.1	GO:0008140	cAMP response element binding protein binding(GO:0008140)
0.1	GO:0031995	insulin-like growth factor II binding(GO:0031995)
0.1	GO:0003836	beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.2	GO:1900750	glutathione binding(GO:0043295) oligopeptide binding(GO:1900750)
0.1	GO:0019870	potassium channel inhibitor activity(GO:0019870)
0.0	GO:0015016	[heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.1	GO:0051400	BH domain binding(GO:0051400)
0.1	GO:0050649	testosterone 6-beta-hydroxylase activity(GO:0050649)
0.1	GO:0102391	decanoate--CoA ligase activity(GO:0102391)
0.0	GO:0030572	cardiolipin synthase activity(GO:0008808) phosphatidyltransferase activity(GO:0030572)
0.1	GO:0070051	fibrinogen binding(GO:0070051)
0.1	GO:0048156	tau protein binding(GO:0048156)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.1	PID AJDISS 2PATHWAY	Posttranslational regulation of adherens junction stability and dissassembly

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Total log-likelihood	Term	Description
0.6	REACTOME SULFUR AMINO ACID METABOLISM	Genes involved in Sulfur amino acid metabolism
0.2	REACTOME ROLE OF DCC IN REGULATING APOPTOSIS	Genes involved in Role of DCC in regulating apoptosis
0.1	REACTOME REGULATED PROTEOLYSIS OF P75NTR	Genes involved in Regulated proteolysis of p75NTR
0.1	REACTOME IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION	Genes involved in IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
0.2	REACTOME PEROXISOMAL LIPID METABOLISM	Genes involved in Peroxisomal lipid metabolism
0.1	REACTOME INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1	Genes involved in Inhibition of replication initiation of damaged DNA by RB1/E2F1
0.3	REACTOME BASIGIN INTERACTIONS	Genes involved in Basigin interactions
0.2	REACTOME REGULATORY RNA PATHWAYS	Genes involved in Regulatory RNA pathways

Results for Pknox2_Pknox1

Z-value: 0.95

Motif logo

Transcription factors associated with Pknox2_Pknox1

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

Activity of the Pknox2_Pknox1 motif across conditions

Conditions sorted by the z-value of the Pknox2_Pknox1 motif activity

Top target CREs of the motif:

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of Pknox2_Pknox1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: