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ENCSR904DTN: DNase-seq of mouse liver in constant darkness

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for Pou3f3

Z-value: 1.00

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Transcription factors associated with Pou3f3

Gene Symbol	Gene ID	Gene Info
Pou3f3 Ensembl NCBI MGI UniProt	ENSMUSG00000045515.2	Pou3f3

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

Gene	Promoter	Distance	Association probability	Pearson corr. coef.	P-value	Plot
Pou3f3	chr1_42699734_42699893	4045	0.155167	0.85	3.0e-02	Click!

Activity of the Pou3f3 motif across conditions

Conditions sorted by the z-value of the Pou3f3 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr8_3046150_3046544	1.29	Gm44634	predicted gene 44634	9947	0.2
chr3_51255928_51256079	1.10	Elf2	E74-like factor 2	4238	0.15
chr10_89492629_89492900	1.03	Nr1h4	nuclear receptor subfamily 1, group H, member 4	13885	0.21
chr3_97649987_97650151	1.01	Prkab2	protein kinase, AMP-activated, beta 2 non-catalytic subunit	8124	0.13
chr13_43549369_43549520	0.91	Mcur1	mitochondrial calcium uniporter regulator 1	3324	0.2
chr3_144109828_144110050	0.89	Gm34078	predicted gene, 34078	25815	0.2
chr15_3470264_3470480	0.84	Ghr	growth hormone receptor	1272	0.6
chr8_93183570_93183871	0.84	Gm45909	predicted gene 45909	7638	0.14
chr16_37902225_37902391	0.74	Gpr156	G protein-coupled receptor 156	14188	0.14
chr8_93164567_93164980	0.73	Ces1d	carboxylesterase 1D	5202	0.15
chr8_93185812_93185963	0.72	Gm45909	predicted gene 45909	5471	0.15
chr9_70446864_70447026	0.71	Rnf111	ring finger 111	6901	0.16
chr15_36280810_36280963	0.70	Rnf19a	ring finger protein 19A	2212	0.2
chr1_67181891_67182275	0.70	Cps1	carbamoyl-phosphate synthetase 1	59057	0.11
chr1_67183580_67183935	0.68	Cps1	carbamoyl-phosphate synthetase 1	60731	0.11
chr11_11931538_11931698	0.65	Grb10	growth factor receptor bound protein 10	6998	0.19
chr8_93165222_93165456	0.65	Ces1d	carboxylesterase 1D	4636	0.15
chr1_31097093_31097258	0.63	4931428L18Rik	RIKEN cDNA 4931428L18 gene	721	0.62
chr17_64676171_64676533	0.62	Man2a1	mannosidase 2, alpha 1	37068	0.18
chr1_71723212_71723548	0.59	Gm5256	predicted gene 5256	8456	0.19
chr2_58773911_58774203	0.57	Upp2	uridine phosphorylase 2	8732	0.21
chr4_150866491_150867250	0.57	Errfi1	ERBB receptor feedback inhibitor 1	11797	0.13
chr12_16633839_16633990	0.56	Lpin1	lipin 1	13052	0.17
chr2_134947281_134947437	0.55	Gm14036	predicted gene 14036	143410	0.04
chr6_13654409_13654594	0.52	Bmt2	base methyltransferase of 25S rRNA 2	23437	0.21
chr11_31675803_31675997	0.52	Bod1	biorientation of chromosomes in cell division 1	4015	0.27
chr1_106630171_106630322	0.51	Gm37053	predicted gene, 37053	23376	0.19
chr5_8842744_8842895	0.49	Abcb1b	ATP-binding cassette, sub-family B (MDR/TAP), member 1B	2458	0.24
chr11_5347339_5347533	0.48	Znrf3	zinc and ring finger 3	34304	0.15
chr2_67977965_67978321	0.48	Gm37964	predicted gene, 37964	79547	0.1
chr10_76531927_76532170	0.48	Lss	lanosterol synthase	366	0.79
chr17_13821264_13821648	0.48	Afdn	afadin, adherens junction formation factor	29506	0.14
chr6_6206187_6206411	0.47	Slc25a13	solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 13	10819	0.23
chr8_93258499_93258650	0.47	Ces1f	carboxylesterase 1F	165	0.94
chr6_138152720_138152908	0.47	Mgst1	microsomal glutathione S-transferase 1	9960	0.28
chr1_13670589_13670740	0.47	Xkr9	X-linked Kx blood group related 9	1893	0.32
chr11_103696519_103696670	0.47	Gosr2	golgi SNAP receptor complex member 2	1100	0.31
chr4_35533897_35534048	0.47	Gm12365	predicted gene 12365	97758	0.08
chr8_101350931_101351097	0.46	Gm22223	predicted gene, 22223	188694	0.03
chr4_108085090_108085394	0.45	Mir6397	microRNA 6397	2115	0.24
chr16_43286493_43286831	0.45	Gm37946	predicted gene, 37946	21619	0.16
chr5_147726852_147727014	0.45	Flt1	FMS-like tyrosine kinase 1	922	0.61
chr6_95652369_95652586	0.44	Suclg2	succinate-Coenzyme A ligase, GDP-forming, beta subunit	4991	0.35
chr3_60097884_60098081	0.44	Sucnr1	succinate receptor 1	16080	0.18
chr1_162892140_162892544	0.43	Fmo2	flavin containing monooxygenase 2	5827	0.19
chr2_112284742_112285127	0.42	Slc12a6	solute carrier family 12, member 6	357	0.81
chr16_42910018_42910191	0.42	Gm19522	predicted gene, 19522	1961	0.29
chr19_17506726_17506895	0.42	Rfk	riboflavin kinase	109373	0.07
chr16_56714341_56714503	0.42	Tfg	Trk-fused gene	1446	0.47
chr3_151831850_151832001	0.41	Ptgfr	prostaglandin F receptor	2230	0.27
chr19_40512528_40512992	0.39	Sorbs1	sorbin and SH3 domain containing 1	913	0.57
chr9_95558523_95558904	0.39	Paqr9	progestin and adipoQ receptor family member IX	944	0.41
chr13_102570134_102570306	0.39	Gm29927	predicted gene, 29927	20065	0.22
chr5_147747897_147748048	0.38	Gm43156	predicted gene 43156	2456	0.3
chr5_17964323_17964474	0.38	Gnat3	guanine nucleotide binding protein, alpha transducing 3	1849	0.49
chr19_58049317_58049501	0.36	Mir5623	microRNA 5623	1758	0.46
chr17_13825284_13825458	0.36	Afdn	afadin, adherens junction formation factor	25591	0.15
chr8_20561636_20561787	0.36	Gm21182	predicted gene, 21182	4225	0.2
chr8_25750286_25750467	0.35	Ddhd2	DDHD domain containing 2	526	0.61
chr6_43643507_43643672	0.35	Tpk1	thiamine pyrophosphokinase	17623	0.25
chr12_4455371_4455763	0.34	Ncoa1	nuclear receptor coactivator 1	21615	0.16
chr7_25422600_25422802	0.34	Gm20949	predicted gene, 20949	91	0.93
chr7_26817080_26817232	0.34	Cyp2g1	cytochrome P450, family 2, subfamily g, polypeptide 1	861	0.56
chr4_48225504_48225656	0.34	Mir1958	microRNA 1958	12365	0.19
chr2_105949709_105950077	0.33	Gm22002	predicted gene, 22002	42864	0.1
chr6_100858577_100858772	0.33	Ppp4r2	protein phosphatase 4, regulatory subunit 2	6097	0.23
chr18_38370754_38370932	0.33	Gm4949	predicted gene 4949	10305	0.12
chr11_54003633_54003801	0.33	Slc22a4	solute carrier family 22 (organic cation transporter), member 4	4247	0.16
chr11_16780614_16780813	0.32	Egfr	epidermal growth factor receptor	28483	0.16
chr13_7307728_7307879	0.31	Gm8725	predicted gene 8725	1	0.99
chr5_90899182_90899382	0.31	Cxcl2	chemokine (C-X-C motif) ligand 2	4589	0.13
chr17_26702508_26702992	0.30	Crebrf	CREB3 regulatory factor	12900	0.14
chr3_60111256_60111413	0.30	Gm24382	predicted gene, 24382	16413	0.19
chr10_4736776_4736976	0.30	Esr1	estrogen receptor 1 (alpha)	24225	0.25
chr2_4999219_4999388	0.30	Mcm10	minichromosome maintenance 10 replication initiation factor	2255	0.21
chr1_3515265_3515420	0.30	Gm37329	predicted gene, 37329	835	0.6
chr2_147905769_147905939	0.29	Gm25516	predicted gene, 25516	30976	0.2
chr3_118606217_118606485	0.29	Dpyd	dihydropyrimidine dehydrogenase	44165	0.15
chr18_66004765_66005080	0.28	Lman1	lectin, mannose-binding, 1	2283	0.22
chr6_24610468_24610637	0.28	Lmod2	leiomodin 2 (cardiac)	12790	0.14
chr4_94555776_94555981	0.28	Caap1	caspase activity and apoptosis inhibitor 1	888	0.53
chr8_20817807_20818117	0.28	Gm20946	predicted gene, 20946	10391	0.15
chr2_160848002_160848255	0.28	Gm11447	predicted gene 11447	2515	0.22
chr4_108096711_108097042	0.27	Podn	podocan	431	0.78
chr19_12684439_12684625	0.27	Gm49772	predicted gene, 49772	2761	0.13
chr3_116302483_116302634	0.27	Gm29151	predicted gene 29151	47545	0.11
chr2_11427432_11427583	0.27	Gm13296	predicted gene 13296	7283	0.12
chr4_97900129_97900314	0.27	Nfia	nuclear factor I/A	10812	0.29
chr3_152478706_152478877	0.27	Ak5	adenylate kinase 5	276	0.91
chrY_90810953_90811113	0.26	Gm47283	predicted gene, 47283	20582	0.16
chr4_136145338_136145489	0.26	Id3	inhibitor of DNA binding 3	439	0.76
chr2_152830017_152830168	0.26	Bcl2l1	BCL2-like 1	218	0.9
chr17_35815959_35816154	0.26	Ier3	immediate early response 3	5628	0.08
chr6_149010896_149011065	0.26	Dennd5b	DENN/MADD domain containing 5B	6208	0.11
chr9_94017367_94017557	0.25	Gm5369	predicted gene 5369	122000	0.06
chr11_111998446_111998808	0.25	Gm11679	predicted gene 11679	44951	0.19
chr1_15616194_15616345	0.25	Gm37138	predicted gene, 37138	60020	0.12
chr6_137754996_137755471	0.25	Dera	deoxyribose-phosphate aldolase (putative)	618	0.77
chr2_17326719_17326870	0.25	Nebl	nebulette	34292	0.22
chr5_96304997_96305161	0.24	Fras1	Fraser extracellular matrix complex subunit 1	68876	0.11
chr5_25496952_25497103	0.24	Kmt2c	lysine (K)-specific methyltransferase 2C	1675	0.26
chr9_49485368_49485519	0.24	Ttc12	tetratricopeptide repeat domain 12	772	0.68
chr1_162815471_162815637	0.24	Fmo4	flavin containing monooxygenase 4	1582	0.37
chr16_37874612_37874787	0.24	Lrrc58	leucine rich repeat containing 58	6310	0.14
chr2_164823177_164823502	0.24	Zswim1	zinc finger SWIM-type containing 1	326	0.72
chrX_170020041_170020212	0.24	Erdr1	erythroid differentiation regulator 1	9382	0.18
chr5_124424178_124424509	0.24	Gm37415	predicted gene, 37415	354	0.67
chr10_4618857_4619069	0.24	Esr1	estrogen receptor 1 (alpha)	6942	0.24
chr6_144170659_144171019	0.23	Sox5	SRY (sex determining region Y)-box 5	33218	0.23
chr9_96952383_96952534	0.23	Spsb4	splA/ryanodine receptor domain and SOCS box containing 4	19517	0.15
chr17_53650070_53650394	0.23	Kat2b	K(lysine) acetyltransferase 2B	5535	0.15
chr16_43247311_43247635	0.23	Zbtb20	zinc finger and BTB domain containing 20	189	0.95
chr10_89450844_89451017	0.23	Gas2l3	growth arrest-specific 2 like 3	6963	0.25
chr1_131287169_131287361	0.22	Ikbke	inhibitor of kappaB kinase epsilon	7659	0.12
chr4_115411935_115412583	0.22	Cyp4a12b	cytochrome P450, family 4, subfamily a, polypeptide 12B	635	0.62
chr2_164447965_164448116	0.22	Sdc4	syndecan 4	4153	0.1
chr18_33352007_33352191	0.22	Gm5503	predicted gene 5503	32856	0.21
chr4_55352435_55352713	0.22	Rad23b	RAD23 homolog B, nucleotide excision repair protein	2484	0.24
chr6_149147053_149147326	0.22	Etfbkmt	electron transfer flavoprotein beta subunit lysine methyltransferase	5543	0.14
chr17_80772516_80772751	0.22	Map4k3	mitogen-activated protein kinase kinase kinase kinase 3	44148	0.15
chr8_20289022_20289260	0.21	6820431F20Rik	RIKEN cDNA 6820431F20 gene	5875	0.25
chr3_105773852_105774003	0.21	Gm43329	predicted gene 43329	3730	0.13
chr4_136246535_136246839	0.21	Tcea3	transcription elongation factor A (SII), 3	1042	0.46
chr5_51537712_51537892	0.21	Ppargc1a	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	16069	0.16
chr9_95540268_95540439	0.21	Gm32281	predicted gene, 32281	14144	0.13
chr9_62087393_62087544	0.21	Glce	glucuronyl C5-epimerase	16628	0.19
chr4_57122143_57122466	0.21	Epb41l4b	erythrocyte membrane protein band 4.1 like 4b	2244	0.35
chr5_87457817_87457968	0.21	Ugt2a2	UDP glucuronosyltransferase 2 family, polypeptide A2	24366	0.1
chr16_58662034_58662449	0.21	Gm49701	predicted gene, 49701	6997	0.13
chr1_71807937_71808302	0.21	Gm37217	predicted gene, 37217	38491	0.15
chr5_90519183_90519413	0.20	Afm	afamin	349	0.81
chr12_32768098_32768327	0.20	Nampt	nicotinamide phosphoribosyltransferase	51333	0.12
chr6_24964522_24964682	0.20	Tmem229a	transmembrane protein 229A	8305	0.22
chr3_97653684_97653893	0.20	Prkab2	protein kinase, AMP-activated, beta 2 non-catalytic subunit	4405	0.15
chr8_127463314_127463465	0.20	Pard3	par-3 family cell polarity regulator	15643	0.28
chr10_115386783_115386953	0.20	Zfc3h1	zinc finger, C3H1-type containing	1909	0.24
chr1_67133525_67134193	0.20	Cps1	carbamoyl-phosphate synthetase 1	10833	0.24
chr2_77173287_77173438	0.20	Ccdc141	coiled-coil domain containing 141	2726	0.29
chr2_58782728_58782879	0.20	Upp2	uridine phosphorylase 2	17478	0.19
chr3_144255924_144256075	0.20	Gm43446	predicted gene 43446	27812	0.16
chr18_60243095_60243283	0.20	Gm5970	predicted gene 5970	22346	0.13
chr9_66600725_66600966	0.19	Usp3	ubiquitin specific peptidase 3	7703	0.2
chr5_86942001_86942153	0.19	Gm24121	predicted gene, 24121	13069	0.09
chr1_170608002_170608165	0.19	Nos1ap	nitric oxide synthase 1 (neuronal) adaptor protein	18222	0.17
chr2_109684188_109684342	0.19	Bdnf	brain derived neurotrophic factor	7233	0.19
chr2_81270788_81270939	0.19	Gm23900	predicted gene, 23900	272479	0.01
chrY_90794490_90794856	0.19	Gm47283	predicted gene, 47283	4222	0.21
chr19_34868908_34869317	0.19	Pank1	pantothenate kinase 1	8737	0.17
chr9_67845546_67845728	0.19	Vps13c	vacuolar protein sorting 13C	5225	0.21
chr4_105179161_105179312	0.19	Plpp3	phospholipid phosphatase 3	21889	0.24
chr1_182959595_182959833	0.19	Tlr5	toll-like receptor 5	4886	0.22
chr6_140199181_140199332	0.19	Gm24174	predicted gene, 24174	32611	0.16
chr11_119048222_119048411	0.19	Cbx8	chromobox 8	7347	0.16
chr11_30773137_30773288	0.19	Psme4	proteasome (prosome, macropain) activator subunit 4	891	0.53
chr6_72431165_72431316	0.18	Mat2a	methionine adenosyltransferase II, alpha	3751	0.13
chrX_170022175_170022352	0.18	Erdr1	erythroid differentiation regulator 1	11519	0.18
chr6_143513821_143514027	0.18	4930579D09Rik	RIKEN cDNA 4930579D09 gene	21584	0.23
chr9_74326904_74327074	0.18	Gm24141	predicted gene, 24141	35621	0.16
chr18_35499140_35499327	0.18	Sil1	endoplasmic reticulum chaperone SIL1 homolog (S. cerevisiae)	304	0.64
chr5_137778433_137778610	0.18	Ppp1r35	protein phosphatase 1, regulatory subunit 35	328	0.76
chr1_65156847_65157132	0.18	Idh1	isocitrate dehydrogenase 1 (NADP+), soluble	18575	0.11
chr17_70661451_70661755	0.17	5031415H12Rik	RIKEN cDNA 5031415H12 gene	93979	0.07
chr1_131990500_131990816	0.17	Slc45a3	solute carrier family 45, member 3	11694	0.12
chr1_21299385_21299536	0.17	Gm4956	predicted gene 4956	1148	0.32
chr8_77100242_77100465	0.17	Nr3c2	nuclear receptor subfamily 3, group C, member 2	27660	0.19
chr5_90696399_90696550	0.17	Gm43090	predicted gene 43090	54051	0.08
chr15_103307817_103307990	0.17	Gpr84	G protein-coupled receptor 84	2709	0.14
chr7_119960819_119960970	0.17	Dnah3	dynein, axonemal, heavy chain 3	6948	0.16
chr3_51917272_51917733	0.17	Gm10728	predicted gene 10728	8686	0.13
chr3_106496243_106496679	0.17	Dennd2d	DENN/MADD domain containing 2D	3286	0.17
chr9_82938706_82938857	0.17	Phip	pleckstrin homology domain interacting protein	5749	0.26
chr17_25447727_25447880	0.17	Tekt4	tektin 4	6812	0.12
chr2_23090654_23090815	0.16	Acbd5	acyl-Coenzyme A binding domain containing 5	3467	0.23
chr14_76800394_76800719	0.16	Gm30246	predicted gene, 30246	19729	0.17
chr8_89207204_89207384	0.16	Gm5356	predicted pseudogene 5356	19734	0.24
chr10_24362809_24362960	0.16	Gm15271	predicted gene 15271	84606	0.08
chr3_37687682_37687873	0.16	Gm43414	predicted gene 43414	20244	0.1
chr16_44149582_44149733	0.16	Naa50	N(alpha)-acetyltransferase 50, NatE catalytic subunit	9765	0.17
chr6_13676526_13676747	0.16	Bmt2	base methyltransferase of 25S rRNA 2	1302	0.55
chr5_146330559_146330717	0.16	Cdk8	cyclin-dependent kinase 8	34273	0.13
chr16_6901477_6901805	0.16	Rbfox1	RNA binding protein, fox-1 homolog (C. elegans) 1	92419	0.1
chr8_68008523_68008836	0.16	Gm22018	predicted gene, 22018	1661	0.43
chr13_23849104_23849255	0.16	Slc17a3	solute carrier family 17 (sodium phosphate), member 3	9589	0.08
chr9_106727325_106727482	0.16	Rad54l2	RAD54 like 2 (S. cerevisiae)	4532	0.19
chrX_109011797_109011968	0.16	Hmgn5	high-mobility group nucleosome binding domain 5	1522	0.29
chr9_22467234_22467805	0.16	Rp9	retinitis pigmentosa 9 (human)	651	0.58
chr9_108797332_108797857	0.16	Ip6k2	inositol hexaphosphate kinase 2	593	0.53
chr8_44937447_44937668	0.16	Fat1	FAT atypical cadherin 1	2110	0.3
chr15_77929755_77929928	0.15	Txn2	thioredoxin 2	835	0.54
chr12_91731624_91731976	0.15	Ston2	stonin 2	12055	0.17
chr15_27461169_27461365	0.15	Gm36899	predicted gene, 36899	2182	0.26
chr3_121778871_121779078	0.15	4633401B06Rik	RIKEN cDNA 4633401B06 gene	9598	0.11
chr8_119925715_119925866	0.15	Usp10	ubiquitin specific peptidase 10	11892	0.16
chr11_74648732_74649171	0.15	Cluh	clustered mitochondria (cluA/CLU1) homolog	544	0.74
chr5_142614394_142614571	0.15	Mmd2	monocyte to macrophage differentiation-associated 2	5682	0.16
chr4_36131854_36132041	0.15	Lingo2	leucine rich repeat and Ig domain containing 2	4516	0.35
chrY_90796785_90796987	0.15	Gm47283	predicted gene, 47283	6435	0.19
chr4_149989662_149989976	0.15	H6pd	hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)	11446	0.15
chr10_71177574_71177846	0.15	1700113B09Rik	RIKEN cDNA 1700113B09 gene	3326	0.15
chr6_37705705_37706037	0.15	Ybx1-ps2	Y box protein 1, pseudogene 2	18676	0.24

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of Pou3f3

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.3	1.0	GO:0019626	short-chain fatty acid catabolic process(GO:0019626)
0.1	0.5	GO:0006549	isoleucine metabolic process(GO:0006549)
0.1	0.3	GO:0006808	regulation of nitrogen utilization(GO:0006808)
0.1	0.2	GO:0052041	negative regulation by symbiont of host apoptotic process(GO:0033668) negative regulation by symbiont of host programmed cell death(GO:0052041) negative regulation by organism of programmed cell death in other organism involved in symbiotic interaction(GO:0052490)
0.1	0.3	GO:0071476	cellular hypotonic response(GO:0071476)
0.1	0.3	GO:0048597	post-embryonic camera-type eye morphogenesis(GO:0048597)
0.1	0.2	GO:0046121	deoxyribonucleoside catabolic process(GO:0046121)
0.0	0.1	GO:0043490	malate-aspartate shuttle(GO:0043490)
0.0	0.1	GO:0006982	response to lipid hydroperoxide(GO:0006982)
0.0	0.1	GO:0060523	prostate epithelial cord elongation(GO:0060523)
0.0	0.1	GO:0071799	response to prostaglandin D(GO:0071798) cellular response to prostaglandin D stimulus(GO:0071799)
0.0	0.2	GO:0070995	NADPH oxidation(GO:0070995)
0.0	0.2	GO:0006526	arginine biosynthetic process(GO:0006526)
0.0	0.1	GO:0006701	progesterone biosynthetic process(GO:0006701)
0.0	0.2	GO:0050917	sensory perception of umami taste(GO:0050917)
0.0	0.1	GO:0046959	habituation(GO:0046959)
0.0	0.1	GO:0006546	glycine catabolic process(GO:0006546) glycine decarboxylation via glycine cleavage system(GO:0019464)
0.0	0.1	GO:0042723	thiamine metabolic process(GO:0006772) thiamine-containing compound metabolic process(GO:0042723)
0.0	0.1	GO:0015842	aminergic neurotransmitter loading into synaptic vesicle(GO:0015842) neurotransmitter loading into synaptic vesicle(GO:0098700)
0.0	0.1	GO:0035093	spermatogenesis, exchange of chromosomal proteins(GO:0035093)
0.0	0.0	GO:1902956	regulation of mitochondrial electron transport, NADH to ubiquinone(GO:1902956)
0.0	0.1	GO:0042737	drug catabolic process(GO:0042737)
0.0	0.1	GO:0014045	establishment of endothelial blood-brain barrier(GO:0014045)
0.0	0.1	GO:0070634	transepithelial ammonium transport(GO:0070634)
0.0	0.1	GO:0045719	negative regulation of glycogen biosynthetic process(GO:0045719)
0.0	0.1	GO:0090370	negative regulation of cholesterol efflux(GO:0090370)
0.0	0.2	GO:0090141	positive regulation of mitochondrial fission(GO:0090141)
0.0	0.1	GO:0006543	glutamine catabolic process(GO:0006543)
0.0	0.2	GO:0051561	positive regulation of mitochondrial calcium ion concentration(GO:0051561)
0.0	0.1	GO:0030579	ubiquitin-dependent SMAD protein catabolic process(GO:0030579)
0.0	0.1	GO:2001013	epithelial cell proliferation involved in renal tubule morphogenesis(GO:2001013)
0.0	0.1	GO:1904017	response to Thyroglobulin triiodothyronine(GO:1904016) cellular response to Thyroglobulin triiodothyronine(GO:1904017)
0.0	0.1	GO:2000189	positive regulation of cholesterol homeostasis(GO:2000189)
0.0	0.0	GO:0006041	glucosamine metabolic process(GO:0006041)
0.0	0.2	GO:0000290	deadenylation-dependent decapping of nuclear-transcribed mRNA(GO:0000290)
0.0	0.1	GO:0030242	pexophagy(GO:0030242)
0.0	0.1	GO:0070345	negative regulation of fat cell proliferation(GO:0070345)
0.0	0.1	GO:0000715	nucleotide-excision repair, DNA damage recognition(GO:0000715)
0.0	0.2	GO:0048280	vesicle fusion with Golgi apparatus(GO:0048280)
0.0	0.1	GO:0070948	regulation of neutrophil mediated cytotoxicity(GO:0070948) regulation of neutrophil mediated killing of symbiont cell(GO:0070949)
0.0	0.1	GO:0006104	succinyl-CoA metabolic process(GO:0006104)
0.0	0.1	GO:0048312	intracellular distribution of mitochondria(GO:0048312)
0.0	0.1	GO:0071139	resolution of recombination intermediates(GO:0071139)
0.0	0.0	GO:0070672	response to interleukin-15(GO:0070672)
0.0	0.0	GO:1903800	positive regulation of production of miRNAs involved in gene silencing by miRNA(GO:1903800)
0.0	0.1	GO:0003383	apical constriction(GO:0003383)
0.0	0.4	GO:0032728	positive regulation of interferon-beta production(GO:0032728)
0.0	0.1	GO:0006642	triglyceride mobilization(GO:0006642)
0.0	0.0	GO:0070346	positive regulation of fat cell proliferation(GO:0070346)
0.0	0.1	GO:0000103	sulfate assimilation(GO:0000103)
0.0	0.0	GO:2000259	positive regulation of complement activation(GO:0045917) positive regulation of protein activation cascade(GO:2000259)
0.0	0.0	GO:0038161	prolactin signaling pathway(GO:0038161)
0.0	0.1	GO:1903242	regulation of cardiac muscle adaptation(GO:0010612) regulation of cardiac muscle hypertrophy in response to stress(GO:1903242)
0.0	0.2	GO:0045725	positive regulation of glycogen biosynthetic process(GO:0045725)
0.0	0.0	GO:0071288	cellular response to mercury ion(GO:0071288)
0.0	0.0	GO:0034146	toll-like receptor 5 signaling pathway(GO:0034146)
0.0	0.1	GO:0006013	mannose metabolic process(GO:0006013)
0.0	0.1	GO:2000741	positive regulation of mesenchymal stem cell differentiation(GO:2000741)
0.0	0.1	GO:0051547	regulation of keratinocyte migration(GO:0051547) positive regulation of keratinocyte migration(GO:0051549)
0.0	0.0	GO:2001180	negative regulation of interleukin-10 secretion(GO:2001180)
0.0	0.1	GO:2000370	positive regulation of clathrin-mediated endocytosis(GO:2000370)
0.0	0.0	GO:0048294	negative regulation of isotype switching to IgE isotypes(GO:0048294)
0.0	0.0	GO:0003340	negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis(GO:0003340)
0.0	0.0	GO:0018879	biphenyl metabolic process(GO:0018879)
0.0	0.0	GO:0051791	medium-chain fatty acid metabolic process(GO:0051791)
0.0	0.0	GO:0032489	regulation of Cdc42 protein signal transduction(GO:0032489)
0.0	0.0	GO:0015959	diadenosine polyphosphate metabolic process(GO:0015959)
0.0	0.0	GO:0002282	microglial cell activation involved in immune response(GO:0002282)
0.0	0.1	GO:2000051	negative regulation of non-canonical Wnt signaling pathway(GO:2000051)
0.0	0.0	GO:0050882	voluntary musculoskeletal movement(GO:0050882)
0.0	0.0	GO:0035790	platelet-derived growth factor receptor-alpha signaling pathway(GO:0035790)
0.0	0.0	GO:0015770	disaccharide transport(GO:0015766) sucrose transport(GO:0015770) oligosaccharide transport(GO:0015772)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.2	GO:0005899	insulin receptor complex(GO:0005899)
0.1	0.2	GO:0097136	Bcl-2 family protein complex(GO:0097136)
0.0	0.2	GO:0045098	type III intermediate filament(GO:0045098)
0.0	0.1	GO:0005785	signal recognition particle receptor complex(GO:0005785)
0.0	0.1	GO:0031088	platelet dense granule membrane(GO:0031088)
0.0	0.2	GO:0030062	mitochondrial tricarboxylic acid cycle enzyme complex(GO:0030062)
0.0	0.2	GO:0005952	cAMP-dependent protein kinase complex(GO:0005952)
0.0	1.3	GO:0005811	lipid particle(GO:0005811)
0.0	0.1	GO:1990111	spermatoproteasome complex(GO:1990111)
0.0	0.1	GO:0033269	internode region of axon(GO:0033269)
0.0	0.2	GO:0012507	ER to Golgi transport vesicle membrane(GO:0012507)
0.0	0.1	GO:0035061	interchromatin granule(GO:0035061)
0.0	0.1	GO:0071942	XPC complex(GO:0071942)
0.0	0.0	GO:0097487	multivesicular body, internal vesicle(GO:0097487)
0.0	0.0	GO:0097441	basilar dendrite(GO:0097441)
0.0	0.1	GO:0031298	replication fork protection complex(GO:0031298)
0.0	0.0	GO:0005879	axonemal microtubule(GO:0005879)
0.0	0.0	GO:0097149	centralspindlin complex(GO:0097149)
0.0	0.1	GO:0046581	intercellular canaliculus(GO:0046581)
0.0	0.1	GO:0031315	extrinsic component of mitochondrial outer membrane(GO:0031315)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.4	GO:0004771	sterol esterase activity(GO:0004771)
0.1	0.2	GO:0038181	bile acid receptor activity(GO:0038181)
0.1	0.2	GO:0016743	carboxyl- or carbamoyltransferase activity(GO:0016743)
0.1	0.3	GO:0022820	potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820)
0.1	0.3	GO:0051434	BH3 domain binding(GO:0051434)
0.1	0.6	GO:0004499	N,N-dimethylaniline monooxygenase activity(GO:0004499)
0.1	0.3	GO:0005021	vascular endothelial growth factor-activated receptor activity(GO:0005021)
0.0	0.4	GO:0031559	oxidosqualene cyclase activity(GO:0031559)
0.0	0.1	GO:0004965	G-protein coupled GABA receptor activity(GO:0004965)
0.0	1.3	GO:0080032	prenylcysteine methylesterase activity(GO:0010296) 1-oxa-2-oxocycloheptane lactonase activity(GO:0018731) sulfolactone hydrolase activity(GO:0018732) butyrolactone hydrolase activity(GO:0018734) endosulfan lactone lactonase activity(GO:0034892) L-ascorbate 6-phosphate lactonase activity(GO:0035460) Ser-tRNA(Thr) hydrolase activity(GO:0043905) Ala-tRNA(Pro) hydrolase activity(GO:0043906) Cys-tRNA(Pro) hydrolase activity(GO:0043907) Ser(Gly)-tRNA(Ala) hydrolase activity(GO:0043908) all-trans-retinyl-palmitate hydrolase, all-trans-retinol forming activity(GO:0047376) mannosyl-oligosaccharide 1,6-alpha-mannosidase activity(GO:0052767) mannosyl-oligosaccharide 1,3-alpha-mannosidase activity(GO:0052768) methyl indole-3-acetate esterase activity(GO:0080030) methyl salicylate esterase activity(GO:0080031) methyl jasmonate esterase activity(GO:0080032)
0.0	0.1	GO:2001070	starch binding(GO:2001070)
0.0	0.1	GO:0015183	L-aspartate transmembrane transporter activity(GO:0015183)
0.0	0.1	GO:0034056	estrogen response element binding(GO:0034056)
0.0	0.3	GO:0004017	adenylate kinase activity(GO:0004017)
0.0	0.1	GO:0070538	oleic acid binding(GO:0070538)
0.0	0.1	GO:0045340	mercury ion binding(GO:0045340)
0.0	0.1	GO:0015377	cation:chloride symporter activity(GO:0015377)
0.0	0.1	GO:0016401	palmitoyl-CoA oxidase activity(GO:0016401)
0.0	0.1	GO:0005220	inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.0	0.1	GO:0008559	xenobiotic-transporting ATPase activity(GO:0008559)
0.0	0.1	GO:0004359	glutaminase activity(GO:0004359)
0.0	0.1	GO:0004062	aryl sulfotransferase activity(GO:0004062)
0.0	0.1	GO:0033142	progesterone receptor binding(GO:0033142)
0.0	0.1	GO:0070053	thrombospondin receptor activity(GO:0070053)
0.0	0.1	GO:0042392	sphingosine-1-phosphate phosphatase activity(GO:0042392)
0.0	0.1	GO:0052723	inositol hexakisphosphate kinase activity(GO:0000828) inositol hexakisphosphate 5-kinase activity(GO:0000832) inositol hexakisphosphate 1-kinase activity(GO:0052723) inositol hexakisphosphate 3-kinase activity(GO:0052724)
0.0	0.2	GO:0016832	aldehyde-lyase activity(GO:0016832)
0.0	0.0	GO:0048408	epidermal growth factor binding(GO:0048408)
0.0	0.1	GO:0032184	SUMO polymer binding(GO:0032184)
0.0	0.1	GO:0016778	diphosphotransferase activity(GO:0016778)
0.0	0.4	GO:0042169	SH2 domain binding(GO:0042169)
0.0	0.2	GO:0004535	poly(A)-specific ribonuclease activity(GO:0004535)
0.0	0.3	GO:0005070	SH3/SH2 adaptor activity(GO:0005070)
0.0	0.1	GO:0008195	phosphatidate phosphatase activity(GO:0008195)
0.0	0.0	GO:0047961	glycine N-acyltransferase activity(GO:0047961)
0.0	0.1	GO:0001135	transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
0.0	0.0	GO:0003829	beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity(GO:0003829)
0.0	0.1	GO:0017150	tRNA dihydrouridine synthase activity(GO:0017150)
0.0	0.2	GO:0004679	AMP-activated protein kinase activity(GO:0004679)
0.0	0.2	GO:0045236	CXCR chemokine receptor binding(GO:0045236)
0.0	0.2	GO:0043295	glutathione binding(GO:0043295) oligopeptide binding(GO:1900750)
0.0	0.1	GO:0004955	prostaglandin receptor activity(GO:0004955)
0.0	0.1	GO:0033743	peptide-methionine (R)-S-oxide reductase activity(GO:0033743)
0.0	0.0	GO:0015157	sucrose:proton symporter activity(GO:0008506) sucrose transmembrane transporter activity(GO:0008515) disaccharide transmembrane transporter activity(GO:0015154) oligosaccharide transmembrane transporter activity(GO:0015157)

Gene overrepresentation in curated gene sets: canonical pathways category:

Total log-likelihood	Term	Description
0.3	PID VEGF VEGFR PATHWAY	VEGF and VEGFR signaling network
0.3	SA PROGRAMMED CELL DEATH	Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.3	PID RXR VDR PATHWAY	RXR and RAR heterodimerization with other nuclear receptor
0.2	PID ERBB NETWORK PATHWAY	ErbB receptor signaling network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Total log-likelihood	Term	Description
0.5	REACTOME PROLACTIN RECEPTOR SIGNALING	Genes involved in Prolactin receptor signaling
0.3	REACTOME VEGF LIGAND RECEPTOR INTERACTIONS	Genes involved in VEGF ligand-receptor interactions
0.0	REACTOME ACTIVATION OF NF KAPPAB IN B CELLS	Genes involved in Activation of NF-kappaB in B Cells
0.4	REACTOME CHOLESTEROL BIOSYNTHESIS	Genes involved in Cholesterol biosynthesis
0.3	REACTOME INFLAMMASOMES	Genes involved in Inflammasomes
0.2	REACTOME PYRIMIDINE CATABOLISM	Genes involved in Pyrimidine catabolism
0.2	REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK	Genes involved in Regulation of Rheb GTPase activity by AMPK
0.2	REACTOME SYNTHESIS OF PE	Genes involved in Synthesis of PE
0.2	REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES	Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.1	REACTOME PROSTANOID LIGAND RECEPTORS	Genes involved in Prostanoid ligand receptors
0.1	REACTOME ALPHA LINOLENIC ACID ALA METABOLISM	Genes involved in alpha-linolenic acid (ALA) metabolism
0.2	REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION	Genes involved in Cyclin A/B1 associated events during G2/M transition
0.1	REACTOME SIGNAL ATTENUATION	Genes involved in Signal attenuation