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ENCSR904DTN: DNase-seq of mouse liver in constant darkness

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for Pou4f3

Z-value: 1.11

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Transcription factors associated with Pou4f3

Gene Symbol	Gene ID	Gene Info
Pou4f3 Ensembl NCBI MGI UniProt	ENSMUSG00000024497.3	Pou4f3

Activity of the Pou4f3 motif across conditions

Conditions sorted by the z-value of the Pou4f3 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr19_4616707_4616858	1.78	Lrfn4	leucine rich repeat and fibronectin type III domain containing 4	1115	0.34
chr15_31279226_31279377	1.17	Gm49296	predicted gene, 49296	2788	0.19
chr19_43971247_43971535	1.15	Cpn1	carboxypeptidase N, polypeptide 1	2698	0.21
chr4_62508801_62509208	1.11	Hdhd3	haloacid dehalogenase-like hydrolase domain containing 3	5537	0.12
chr19_46138051_46138212	1.09	Pitx3	paired-like homeodomain transcription factor 3	842	0.48
chr6_51392183_51392564	1.00	0610033M10Rik	RIKEN cDNA 0610033M10 gene	9660	0.17
chr8_128113288_128113439	0.99	Mir21c	microRNA 21c	164862	0.04
chr2_136986571_136986744	0.83	Slx4ip	SLX4 interacting protein	81114	0.08
chr6_113828811_113828998	0.80	Gm44167	predicted gene, 44167	29220	0.13
chr18_46336206_46336490	0.79	4930415P13Rik	RIKEN cDNA 4930415P13 gene	4081	0.17
chr12_71430131_71430651	0.77	1700083H02Rik	RIKEN cDNA 1700083H02 gene	46183	0.12
chr5_113041682_113041833	0.74	Gm22740	predicted gene, 22740	2387	0.2
chr11_70713419_70713657	0.73	Mir6925	microRNA 6925	7548	0.08
chr9_63201496_63201967	0.73	Skor1	SKI family transcriptional corepressor 1	52770	0.12
chr8_126663289_126663717	0.72	Irf2bp2	interferon regulatory factor 2 binding protein 2	69517	0.1
chr9_7571293_7571444	0.72	Mmp27	matrix metallopeptidase 27	28	0.97
chr5_145986007_145986356	0.70	Cyp3a25	cytochrome P450, family 3, subfamily a, polypeptide 25	5462	0.14
chr10_75625748_75625899	0.69	Gm19688	predicted gene, 19688	6320	0.11
chr6_71236030_71236205	0.68	Smyd1	SET and MYND domain containing 1	19243	0.1
chr16_24394028_24394581	0.67	Lpp	LIM domain containing preferred translocation partner in lipoma	566	0.73
chr15_79690269_79690868	0.67	Gtpbp1	GTP binding protein 1	277	0.78
chr16_93742880_93743193	0.65	Dop1b	DOP1 leucine zipper like protein B	12937	0.16
chr10_68558838_68559075	0.65	Cabcoco1	ciliary associated calcium binding coiled-coil 1	17060	0.22
chr11_109475236_109475399	0.64	Slc16a6	solute carrier family 16 (monocarboxylic acid transporters), member 6	1719	0.22
chr8_108101452_108101603	0.64	Zfhx3	zinc finger homeobox 3	106968	0.07
chr4_45967836_45967998	0.63	Tdrd7	tudor domain containing 7	2583	0.3
chr1_183979753_183980270	0.63	Dusp10	dual specificity phosphatase 10	33291	0.16
chr3_94338287_94338715	0.63	Gm43743	predicted gene 43743	3169	0.1
chr1_184622020_184622382	0.62	Gm37800	predicted gene, 37800	4230	0.18
chr17_70746763_70747075	0.62	5031415H12Rik	RIKEN cDNA 5031415H12 gene	8663	0.19
chr9_30613779_30614132	0.61	Gm47716	predicted gene, 47716	18632	0.24
chr8_11149308_11149679	0.60	Gm44717	predicted gene 44717	247	0.91
chr5_43157097_43157384	0.60	Gm42552	predicted gene 42552	8913	0.21
chr19_44027305_44027461	0.60	Cyp2c23	cytochrome P450, family 2, subfamily c, polypeptide 23	1816	0.28
chr8_113141217_113141373	0.58	Gm10280	predicted gene 10280	74033	0.12
chr12_35284123_35284298	0.57	Gm44396	predicted gene, 44396	24681	0.22
chr12_91929732_91929921	0.57	Rpl31-ps1	ribosomal protein L31, pseudogene 1	38553	0.11
chr4_33229770_33229937	0.55	Pnrc1	proline-rich nuclear receptor coactivator 1	17722	0.14
chr17_43299707_43299871	0.54	Adgrf1	adhesion G protein-coupled receptor F1	29460	0.2
chr3_28736802_28736989	0.53	1700112D23Rik	RIKEN cDNA 1700112D23 gene	5345	0.16
chr11_109500636_109500796	0.52	Gm22378	predicted gene, 22378	892	0.5
chr3_98067419_98067570	0.52	Gm42819	predicted gene 42819	36807	0.13
chr4_57525649_57525867	0.51	Pakap	paralemmin A kinase anchor protein	42401	0.16
chr1_44130037_44130209	0.51	Bivm	basic, immunoglobulin-like variable motif containing	10144	0.12
chr17_84037207_84037358	0.50	Gm49967	predicted gene, 49967	392	0.78
chr4_137481328_137481504	0.50	Hspg2	perlecan (heparan sulfate proteoglycan 2)	12613	0.13
chr4_60236200_60236578	0.49	Mup-ps3	major urinary protein, pseudogene 3	956	0.56
chr10_43245095_43245284	0.49	Pdss2	prenyl (solanesyl) diphosphate synthase, subunit 2	23453	0.16
chr11_121616042_121616235	0.49	Tbcd	tubulin-specific chaperone d	14433	0.2
chr10_68269443_68270351	0.49	Arid5b	AT rich interactive domain 5B (MRF1-like)	8824	0.23
chr14_50991070_50991230	0.49	Gm49038	predicted gene, 49038	5925	0.08
chr4_21739391_21739542	0.49	Ccnc	cyclin C	11699	0.16
chr4_61317592_61317969	0.48	Mup-ps11	major urinary protein, pseudogene 11	950	0.58
chr14_8331646_8331805	0.47	Fam107a	family with sequence similarity 107, member A	13702	0.18
chr19_43767883_43768034	0.46	Cutc	cutC copper transporter	3085	0.18
chr13_24950116_24950267	0.46	Gpld1	glycosylphosphatidylinositol specific phospholipase D1	5663	0.14
chr10_21665548_21665708	0.46	Gm5420	predicted gene 5420	20783	0.2
chr15_81897988_81898152	0.46	Aco2	aconitase 2, mitochondrial	2764	0.13
chr4_60436201_60436591	0.46	Mup-ps4	major urinary protein, pseudogene 4	966	0.47
chr7_140127944_140128095	0.46	Paox	polyamine oxidase (exo-N4-amino)	2311	0.14
chr1_187214930_187215194	0.46	Spata17	spermatogenesis associated 17	359	0.55
chr3_80042843_80043016	0.45	A330069K06Rik	RIKEN cDNA A330069K06 gene	11963	0.22
chr12_106479388_106479572	0.45	Gm3191	predicted gene 3191	20330	0.16
chr5_49344702_49344867	0.45	Kcnip4	Kv channel interacting protein 4	59125	0.1
chr5_138080510_138080792	0.44	Zkscan1	zinc finger with KRAB and SCAN domains 1	4433	0.1
chr1_88177823_88178019	0.44	AC087801.3	UDP glycosyltransferase 1 family (Ugt1) pseudogene	380	0.64
chr10_115337191_115337351	0.44	Tmem19	transmembrane protein 19	11793	0.14
chr1_21228840_21229005	0.44	Gm38224	predicted gene, 38224	5800	0.13
chr3_104220440_104221564	0.44	Magi3	membrane associated guanylate kinase, WW and PDZ domain containing 3	628	0.6
chr16_4395267_4395559	0.43	Adcy9	adenylate cyclase 9	24174	0.18
chr19_61057720_61057890	0.43	Gm22520	predicted gene, 22520	44260	0.12
chr15_83454522_83454702	0.43	Pacsin2	protein kinase C and casein kinase substrate in neurons 2	9940	0.15
chr16_22919975_22920126	0.43	Fetub	fetuin beta	187	0.91
chr10_21459651_21460332	0.42	Gm48386	predicted gene, 48386	14355	0.15
chr17_30618531_30618854	0.42	Dnah8	dynein, axonemal, heavy chain 8	5662	0.11
chr11_111605518_111605669	0.42	Gm11676	predicted gene 11676	7713	0.32
chr13_95777366_95777529	0.42	Iqgap2	IQ motif containing GTPase activating protein 2	13050	0.19
chr3_83155696_83155887	0.41	Gm10710	predicted gene 10710	26545	0.17
chr6_124666813_124667013	0.41	Lpcat3	lysophosphatidylcholine acyltransferase 3	3698	0.1
chr16_38945803_38945963	0.41	Gm22500	predicted gene, 22500	18674	0.2
chr1_131465972_131466299	0.41	Gm29487	predicted gene 29487	18440	0.14
chr1_172514217_172514368	0.41	Gm37125	predicted gene, 37125	1043	0.35
chr4_142088876_142089143	0.40	Tmem51os1	Tmem51 opposite strand 1	4153	0.16
chr15_95897464_95897657	0.40	Gm25070	predicted gene, 25070	17743	0.17
chr14_51100561_51100914	0.40	Rnase4	ribonuclease, RNase A family 4	4378	0.09
chr10_94080659_94080847	0.40	Fgd6	FYVE, RhoGEF and PH domain containing 6	8211	0.13
chr7_51887680_51888069	0.39	Gas2	growth arrest specific 2	44	0.97
chr11_7519967_7520118	0.39	Gm11986	predicted gene 11986	229668	0.02
chr1_77965517_77965856	0.39	Gm28387	predicted gene 28387	6690	0.29
chr2_119566293_119566470	0.39	Chp1	calcineurin-like EF hand protein 1	224	0.89
chr1_179352076_179352287	0.39	Smyd3	SET and MYND domain containing 3	21922	0.26
chr1_21131249_21131442	0.39	Gm2693	predicted gene 2693	47643	0.1
chr4_116720481_116720689	0.39	Tesk2	testis-specific kinase 2	363	0.78
chr8_34506104_34506386	0.38	Gm8268	predicted gene 8268	962	0.54
chr5_145464782_145464950	0.38	Cyp3a16	cytochrome P450, family 3, subfamily a, polypeptide 16	4857	0.19
chr4_81841873_81842024	0.38	n-R5s187	nuclear encoded rRNA 5S 187	76565	0.1
chr2_43548853_43549055	0.38	Kynu	kynureninase	6375	0.28
chr11_86951820_86952000	0.38	Ypel2	yippee like 2	20114	0.17
chr17_29381584_29381926	0.38	Fgd2	FYVE, RhoGEF and PH domain containing 2	5254	0.14
chr9_103363870_103364326	0.38	Cdv3	carnitine deficiency-associated gene expressed in ventricle 3	799	0.56
chr9_43104579_43104740	0.37	Arhgef12	Rho guanine nucleotide exchange factor (GEF) 12	827	0.61
chr12_99418906_99419292	0.37	Foxn3	forkhead box N3	6494	0.18
chr10_20046183_20046505	0.37	Map3k5	mitogen-activated protein kinase kinase kinase 5	53181	0.13
chr12_71899715_71899878	0.37	Daam1	dishevelled associated activator of morphogenesis 1	10066	0.23
chr19_43768047_43768256	0.37	Cutc	cutC copper transporter	3278	0.18
chr1_127011786_127011937	0.37	Gm5261	predicted gene 5261	38835	0.2
chr13_74769953_74770127	0.37	Cast	calpastatin	550	0.67
chr6_54849831_54850051	0.36	Znrf2	zinc and ring finger 2	32493	0.16
chr4_62088107_62088281	0.36	Gm12909	predicted gene 12909	94	0.92
chr1_133251724_133252043	0.36	Gm19461	predicted gene, 19461	2409	0.23
chr19_38127249_38127411	0.36	Rbp4	retinol binding protein 4, plasma	2049	0.25
chr15_67062759_67062944	0.36	Gm31342	predicted gene, 31342	22793	0.2
chr17_12924054_12924394	0.36	Snora20	small nucleolar RNA, H/ACA box 20	1434	0.19
chr16_31986976_31987127	0.36	Gm49733	predicted gene, 49733	72	0.81
chr19_5840987_5841190	0.36	Neat1	nuclear paraspeckle assembly transcript 1 (non-protein coding)	4171	0.09
chr4_35101216_35101367	0.36	Ifnk	interferon kappa	50765	0.12
chr5_130264636_130264798	0.35	Tyw1	tRNA-yW synthesizing protein 1 homolog (S. cerevisiae)	5787	0.13
chr3_155092466_155092737	0.35	Fpgt	fucose-1-phosphate guanylyltransferase	46	0.94
chr6_35874026_35874908	0.35	Gm43442	predicted gene 43442	52244	0.17
chr1_88764125_88764295	0.35	Platr5	pluripotency associated transcript 5	9256	0.2
chr4_55516147_55516328	0.35	Gm12507	predicted gene 12507	7943	0.16
chr1_178330385_178330898	0.35	Hnrnpu	heterogeneous nuclear ribonucleoprotein U	20	0.96
chr7_138913719_138913877	0.35	Gm9358	predicted gene 9358	590	0.61
chr4_60676733_60676914	0.35	Mup-ps7	major urinary protein, pseudogene 7	860	0.58
chr7_121469578_121469762	0.35	Gm36736	predicted gene, 36736	76569	0.08
chr6_121874198_121874349	0.35	Mug1	murinoglobulin 1	11304	0.19
chr6_12465944_12466328	0.34	Thsd7a	thrombospondin, type I, domain containing 7A	46775	0.18
chr4_63738674_63738850	0.34	Tnfsf15	tumor necrosis factor (ligand) superfamily, member 15	6351	0.22
chrX_75409783_75409942	0.34	Cmc4	C-x(9)-C motif containing 4	50	0.95
chrX_71331504_71331669	0.34	Mtm1	X-linked myotubular myopathy gene 1	30217	0.17
chr11_60786182_60786455	0.34	Shmt1	serine hydroxymethyltransferase 1 (soluble)	6855	0.08
chr5_87091073_87091224	0.34	Ugt2b36	UDP glucuronosyltransferase 2 family, polypeptide B36	9	0.96
chr9_32874453_32874604	0.34	Gm37167	predicted gene, 37167	34606	0.16
chr4_60303896_60304116	0.34	Mup-ps3	major urinary protein, pseudogene 3	66661	0.08
chr9_69291273_69291476	0.33	Rora	RAR-related orphan receptor alpha	1692	0.45
chr15_90344050_90344371	0.33	Gm36480	predicted gene, 36480	9496	0.28
chr5_66979311_66979467	0.33	Limch1	LIM and calponin homology domains 1	2371	0.2
chr9_115403471_115403629	0.33	Gm9487	predicted gene 9487	1599	0.28
chr1_184290067_184290274	0.33	Gm37223	predicted gene, 37223	68159	0.11
chr7_79985891_79986050	0.33	Gm24541	predicted gene, 24541	36783	0.08
chr19_36735506_36735662	0.33	Ppp1r3c	protein phosphatase 1, regulatory subunit 3C	1069	0.56
chr1_136229022_136229181	0.33	Inava	innate immunity activator	918	0.4
chr13_98578566_98578736	0.33	Gm22698	predicted gene, 22698	18297	0.12
chr19_34518935_34519125	0.33	Lipa	lysosomal acid lipase A	8050	0.13
chr2_159732589_159732753	0.33	Gm11445	predicted gene 11445	45536	0.19
chr6_73281111_73281418	0.33	Suclg1	succinate-CoA ligase, GDP-forming, alpha subunit	20904	0.16
chr11_100836746_100836921	0.32	Stat5b	signal transducer and activator of transcription 5B	13705	0.12
chrX_161939930_161940295	0.32	Gm15202	predicted gene 15202	31889	0.21
chr10_93078296_93078483	0.32	Cfap54	cilia and flagella associated protein 54	3207	0.26
chr5_16470617_16470792	0.32	Gm8984	predicted gene 8984	38479	0.17
chr4_84102833_84103037	0.32	Gm12416	predicted gene 12416	1960	0.38
chr14_46545888_46546175	0.32	E130120K24Rik	RIKEN cDNA E130120K24 gene	10272	0.13
chr10_31644816_31644968	0.32	Gm8793	predicted gene 8793	5734	0.23
chr11_78418219_78418374	0.32	Slc13a2	solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2	3921	0.12
chr6_47819662_47819827	0.32	Rpl35a-ps7	ribosomal protein L35A, pseudogene 7	4112	0.12
chr12_25127702_25127874	0.32	Gm17746	predicted gene, 17746	1386	0.38
chr18_39827979_39828276	0.31	Pabpc2	poly(A) binding protein, cytoplasmic 2	54630	0.14
chr1_84877752_84878205	0.31	Fbxo36	F-box protein 36	8827	0.16
chr8_71405347_71405498	0.31	Ankle1	ankyrin repeat and LEM domain containing 1	588	0.54
chr15_70531676_70531845	0.31	Gm18155	predicted gene, 18155	226293	0.02
chr13_98684591_98684906	0.31	Tmem171	transmembrane protein 171	10020	0.14
chr1_105199808_105199959	0.31	Gm29013	predicted gene 29013	44542	0.16
chr4_150685463_150685649	0.31	Gm16079	predicted gene 16079	6764	0.21
chr11_83852736_83852913	0.31	Hnf1b	HNF1 homeobox B	136	0.94
chr9_71163225_71163399	0.31	Aqp9	aquaporin 9	23	0.9
chr9_115915920_115916106	0.31	Gadl1	glutamate decarboxylase-like 1	6558	0.28
chr3_116936111_116936286	0.30	Gm42892	predicted gene 42892	8132	0.15
chr4_141718181_141718503	0.30	Ddi2	DNA-damage inducible protein 2	5077	0.14
chr3_27431035_27431235	0.30	Ghsr	growth hormone secretagogue receptor	59784	0.12
chr4_132946310_132946569	0.30	Gm24913	predicted gene, 24913	15122	0.13
chr19_5829011_5829567	0.30	Neat1	nuclear paraspeckle assembly transcript 1 (non-protein coding)	1277	0.22
chr4_61697893_61698073	0.30	Mup-ps15	major urinary protein, pseudogene 15	858	0.56
chr13_55613655_55613852	0.30	Gm15911	predicted gene 15911	8970	0.1
chr1_138992310_138992466	0.30	Gm16305	predicted gene 16305	319	0.81
chr9_78501386_78501557	0.30	Eef1a1	eukaryotic translation elongation factor 1 alpha 1	12320	0.11
chr12_78248706_78249176	0.30	Gm18899	predicted gene, 18899	7494	0.15
chr17_36032663_36032990	0.29	H2-T23	histocompatibility 2, T region locus 23	29	0.92
chr3_81995449_81996057	0.29	Asic5	acid-sensing (proton-gated) ion channel family member 5	1169	0.45
chr15_91013020_91013330	0.29	Kif21a	kinesin family member 21A	36643	0.14
chr2_120170818_120170979	0.29	Ehd4	EH-domain containing 4	16292	0.15
chr10_21467545_21467696	0.29	Gm48386	predicted gene, 48386	21984	0.14
chr8_64965219_64965377	0.29	Tmem192	transmembrane protein 192	5755	0.12
chr14_75179701_75179900	0.29	Lcp1	lymphocyte cytosolic protein 1	3592	0.19
chr10_20076891_20077084	0.29	Map3k5	mitogen-activated protein kinase kinase kinase 5	22538	0.2
chr2_165921904_165922055	0.29	Gm11461	predicted gene 11461	3862	0.16
chr4_144957116_144957269	0.29	Gm38074	predicted gene, 38074	1656	0.38
chr12_98860402_98860781	0.29	A930040O22Rik	RIKEN cDNA A930040O22 gene	28778	0.12
chr1_58149355_58149553	0.28	Gm24548	predicted gene, 24548	5634	0.2
chr2_32727271_32727422	0.28	Sh2d3c	SH2 domain containing 3C	360	0.69
chr4_62015707_62015880	0.28	Mup-ps20	major urinary protein, pseudogene 20	936	0.5
chr11_98339208_98339359	0.28	Ppp1r1b	protein phosphatase 1, regulatory inhibitor subunit 1B	9121	0.09
chr17_5012388_5012845	0.28	Arid1b	AT rich interactive domain 1B (SWI-like)	16187	0.23
chr6_94226332_94226483	0.28	Magi1	membrane associated guanylate kinase, WW and PDZ domain containing 1	56618	0.14
chr7_38187215_38187367	0.28	1600014C10Rik	RIKEN cDNA 1600014C10 gene	1020	0.43
chr1_156056827_156057192	0.28	Tor1aip2	torsin A interacting protein 2	6204	0.17
chr3_122939334_122939509	0.28	Usp53	ubiquitin specific peptidase 53	10206	0.12
chr2_57182280_57182573	0.28	4930555B11Rik	RIKEN cDNA 4930555B11 gene	595	0.46
chr2_126551230_126551540	0.28	Slc27a2	solute carrier family 27 (fatty acid transporter), member 2	1022	0.56
chr18_34328570_34328733	0.28	Srp19	signal recognition particle 19	2196	0.29
chr16_91379054_91379459	0.27	Ifnar2	interferon (alpha and beta) receptor 2	6357	0.12

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of Pou4f3

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.5	GO:0042663	regulation of endodermal cell fate specification(GO:0042663)
0.1	0.3	GO:0010911	regulation of isomerase activity(GO:0010911) positive regulation of isomerase activity(GO:0010912)
0.1	0.3	GO:2000566	positive regulation of CD8-positive, alpha-beta T cell proliferation(GO:2000566)
0.1	0.3	GO:0032417	positive regulation of sodium:proton antiporter activity(GO:0032417)
0.1	0.2	GO:0045472	response to ether(GO:0045472)
0.1	0.2	GO:0048807	female genitalia morphogenesis(GO:0048807)
0.1	0.2	GO:0046985	positive regulation of hemoglobin biosynthetic process(GO:0046985)
0.1	0.3	GO:0015722	canalicular bile acid transport(GO:0015722)
0.1	0.2	GO:0035694	mitochondrial protein catabolic process(GO:0035694)
0.1	0.2	GO:0007023	post-chaperonin tubulin folding pathway(GO:0007023)
0.1	0.2	GO:2000503	positive regulation of natural killer cell chemotaxis(GO:2000503)
0.1	0.2	GO:0045917	positive regulation of complement activation(GO:0045917) positive regulation of protein activation cascade(GO:2000259)
0.1	0.2	GO:0046504	ether lipid biosynthetic process(GO:0008611) glycerol ether biosynthetic process(GO:0046504) cellular lipid biosynthetic process(GO:0097384) ether biosynthetic process(GO:1901503)
0.0	0.3	GO:0010815	bradykinin catabolic process(GO:0010815)
0.0	0.1	GO:0061535	glutamate secretion, neurotransmission(GO:0061535)
0.0	0.1	GO:0046544	development of secondary male sexual characteristics(GO:0046544)
0.0	0.0	GO:0019344	cysteine biosynthetic process(GO:0019344)
0.0	0.1	GO:0002414	immunoglobulin transcytosis in epithelial cells(GO:0002414)
0.0	0.1	GO:0008355	olfactory learning(GO:0008355)
0.0	0.2	GO:0046499	S-adenosylmethioninamine metabolic process(GO:0046499)
0.0	0.1	GO:0032474	otolith morphogenesis(GO:0032474)
0.0	0.2	GO:0009115	xanthine catabolic process(GO:0009115)
0.0	0.1	GO:1902956	regulation of mitochondrial electron transport, NADH to ubiquinone(GO:1902956)
0.0	0.1	GO:0035964	COPI-coated vesicle budding(GO:0035964)
0.0	0.1	GO:0060266	negative regulation of respiratory burst involved in inflammatory response(GO:0060266)
0.0	0.2	GO:0007343	egg activation(GO:0007343)
0.0	0.1	GO:1904059	regulation of locomotor rhythm(GO:1904059)
0.0	0.1	GO:1903297	regulation of hypoxia-induced intrinsic apoptotic signaling pathway(GO:1903297) negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway(GO:1903298)
0.0	0.1	GO:0042138	meiotic DNA double-strand break formation(GO:0042138)
0.0	0.1	GO:0061470	T follicular helper cell differentiation(GO:0061470)
0.0	0.2	GO:0072310	glomerular visceral epithelial cell development(GO:0072015) glomerular epithelial cell development(GO:0072310)
0.0	0.2	GO:0045053	protein retention in Golgi apparatus(GO:0045053)
0.0	0.1	GO:0072061	inner medullary collecting duct development(GO:0072061)
0.0	0.1	GO:0019371	cyclooxygenase pathway(GO:0019371)
0.0	0.1	GO:0014045	establishment of endothelial blood-brain barrier(GO:0014045)
0.0	0.1	GO:0006681	galactosylceramide metabolic process(GO:0006681)
0.0	0.2	GO:0071073	positive regulation of phospholipid biosynthetic process(GO:0071073)
0.0	0.7	GO:0070306	lens fiber cell differentiation(GO:0070306)
0.0	0.1	GO:0043152	induction of bacterial agglutination(GO:0043152)
0.0	0.2	GO:0044539	long-chain fatty acid import(GO:0044539)
0.0	0.1	GO:0061073	ciliary body morphogenesis(GO:0061073)
0.0	0.3	GO:0006957	complement activation, alternative pathway(GO:0006957)
0.0	0.1	GO:0015817	histidine transport(GO:0015817)
0.0	0.1	GO:0032430	positive regulation of phospholipase A2 activity(GO:0032430)
0.0	0.2	GO:0060613	fat pad development(GO:0060613)
0.0	0.1	GO:0003289	atrial septum primum morphogenesis(GO:0003289)
0.0	0.0	GO:0070782	phosphatidylserine exposure on apoptotic cell surface(GO:0070782)
0.0	0.1	GO:0034197	acylglycerol transport(GO:0034196) triglyceride transport(GO:0034197)
0.0	0.1	GO:0016344	meiotic chromosome movement towards spindle pole(GO:0016344)
0.0	0.0	GO:1990791	dorsal root ganglion development(GO:1990791)
0.0	0.1	GO:0046208	spermine catabolic process(GO:0046208)
0.0	0.2	GO:0034374	low-density lipoprotein particle remodeling(GO:0034374)
0.0	0.5	GO:0061014	positive regulation of mRNA catabolic process(GO:0061014)
0.0	0.1	GO:0045900	negative regulation of translational elongation(GO:0045900)
0.0	0.3	GO:0021702	cerebellar Purkinje cell differentiation(GO:0021702)
0.0	0.1	GO:0032100	positive regulation of response to food(GO:0032097) positive regulation of appetite(GO:0032100)
0.0	0.1	GO:0060300	regulation of cytokine activity(GO:0060300)
0.0	0.1	GO:0034638	phosphatidylcholine catabolic process(GO:0034638)
0.0	0.1	GO:0045964	positive regulation of catecholamine metabolic process(GO:0045915) positive regulation of dopamine metabolic process(GO:0045964)
0.0	0.1	GO:1900377	negative regulation of melanin biosynthetic process(GO:0048022) negative regulation of secondary metabolite biosynthetic process(GO:1900377)
0.0	0.1	GO:1903660	regulation of complement-dependent cytotoxicity(GO:1903659) negative regulation of complement-dependent cytotoxicity(GO:1903660)
0.0	0.1	GO:0010724	regulation of definitive erythrocyte differentiation(GO:0010724)
0.0	0.1	GO:0097503	sialylation(GO:0097503)
0.0	0.1	GO:0003383	apical constriction(GO:0003383)
0.0	0.2	GO:0051601	exocyst localization(GO:0051601)
0.0	0.1	GO:0051081	membrane disassembly(GO:0030397) nuclear envelope disassembly(GO:0051081)
0.0	0.1	GO:0001692	histamine metabolic process(GO:0001692)
0.0	0.1	GO:0061074	regulation of neural retina development(GO:0061074)
0.0	0.1	GO:0031848	protection from non-homologous end joining at telomere(GO:0031848)
0.0	0.1	GO:0070327	thyroid hormone transport(GO:0070327)
0.0	0.1	GO:0010510	regulation of acetyl-CoA biosynthetic process from pyruvate(GO:0010510)
0.0	0.1	GO:0060686	negative regulation of prostatic bud formation(GO:0060686)
0.0	0.1	GO:0006295	nucleotide-excision repair, DNA incision, 3'-to lesion(GO:0006295)
0.0	0.1	GO:0007161	calcium-independent cell-matrix adhesion(GO:0007161)
0.0	0.1	GO:0008090	retrograde axonal transport(GO:0008090)
0.0	0.1	GO:0038108	negative regulation of appetite by leptin-mediated signaling pathway(GO:0038108)
0.0	0.1	GO:1902093	positive regulation of sperm motility(GO:1902093)
0.0	0.1	GO:0048295	positive regulation of isotype switching to IgE isotypes(GO:0048295)
0.0	0.1	GO:0000707	meiotic DNA recombinase assembly(GO:0000707)
0.0	0.0	GO:0060397	JAK-STAT cascade involved in growth hormone signaling pathway(GO:0060397)
0.0	0.0	GO:0045415	negative regulation of interleukin-8 biosynthetic process(GO:0045415)
0.0	0.1	GO:0019243	methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione(GO:0019243) methylglyoxal catabolic process(GO:0051596) methylglyoxal catabolic process to lactate(GO:0061727)
0.0	0.1	GO:0019346	homoserine metabolic process(GO:0009092) transsulfuration(GO:0019346)
0.0	0.0	GO:0090230	regulation of centromere complex assembly(GO:0090230)
0.0	0.1	GO:0090206	negative regulation of cholesterol biosynthetic process(GO:0045541) negative regulation of cholesterol metabolic process(GO:0090206)
0.0	0.1	GO:0035336	long-chain fatty-acyl-CoA metabolic process(GO:0035336)
0.0	0.0	GO:0010520	regulation of reciprocal meiotic recombination(GO:0010520)
0.0	0.0	GO:0051790	short-chain fatty acid biosynthetic process(GO:0051790)
0.0	0.0	GO:0046271	phenylpropanoid catabolic process(GO:0046271)
0.0	0.1	GO:0031441	negative regulation of mRNA 3'-end processing(GO:0031441) regulation of mRNA polyadenylation(GO:1900363) negative regulation of mRNA polyadenylation(GO:1900364)
0.0	0.1	GO:0030575	nuclear body organization(GO:0030575)
0.0	0.0	GO:1902947	regulation of tau-protein kinase activity(GO:1902947)
0.0	0.1	GO:0046146	tetrahydrobiopterin metabolic process(GO:0046146)
0.0	0.1	GO:2000766	negative regulation of cytoplasmic translation(GO:2000766)
0.0	0.0	GO:1902915	negative regulation of protein K63-linked ubiquitination(GO:1900045) negative regulation of protein polyubiquitination(GO:1902915)
0.0	0.0	GO:0042374	phylloquinone metabolic process(GO:0042374) phylloquinone catabolic process(GO:0042376) quinone catabolic process(GO:1901662)
0.0	0.1	GO:0019720	Mo-molybdopterin cofactor biosynthetic process(GO:0006777) Mo-molybdopterin cofactor metabolic process(GO:0019720) molybdopterin cofactor biosynthetic process(GO:0032324) molybdopterin cofactor metabolic process(GO:0043545) prosthetic group metabolic process(GO:0051189)
0.0	0.1	GO:1900246	positive regulation of RIG-I signaling pathway(GO:1900246)
0.0	0.1	GO:0003149	membranous septum morphogenesis(GO:0003149)
0.0	0.4	GO:0007339	binding of sperm to zona pellucida(GO:0007339)
0.0	0.0	GO:0006578	amino-acid betaine biosynthetic process(GO:0006578)
0.0	0.0	GO:0002430	complement receptor mediated signaling pathway(GO:0002430)
0.0	0.0	GO:1990168	protein K29-linked deubiquitination(GO:0035523) protein K33-linked deubiquitination(GO:1990168)
0.0	0.0	GO:0035434	copper ion transmembrane transport(GO:0035434)
0.0	0.0	GO:0051791	medium-chain fatty acid metabolic process(GO:0051791)
0.0	0.0	GO:0072378	blood coagulation, fibrin clot formation(GO:0072378)
0.0	0.0	GO:0035928	rRNA import into mitochondrion(GO:0035928)
0.0	0.0	GO:0038171	cannabinoid signaling pathway(GO:0038171) endocannabinoid signaling pathway(GO:0071926)
0.0	0.0	GO:0006556	S-adenosylmethionine biosynthetic process(GO:0006556)
0.0	0.0	GO:0038128	ERBB2 signaling pathway(GO:0038128)
0.0	0.1	GO:0070842	aggresome assembly(GO:0070842)
0.0	0.1	GO:0051151	negative regulation of smooth muscle cell differentiation(GO:0051151)
0.0	0.0	GO:0042360	vitamin E metabolic process(GO:0042360)
0.0	0.1	GO:0032000	positive regulation of fatty acid beta-oxidation(GO:0032000)
0.0	0.0	GO:0070294	renal sodium ion absorption(GO:0070294)
0.0	0.0	GO:0042117	monocyte activation(GO:0042117)
0.0	0.0	GO:0006741	NADP biosynthetic process(GO:0006741)
0.0	0.0	GO:0009235	cobalamin metabolic process(GO:0009235)
0.0	0.1	GO:0010961	cellular magnesium ion homeostasis(GO:0010961)
0.0	0.1	GO:0006528	asparagine metabolic process(GO:0006528)
0.0	0.0	GO:0042536	negative regulation of tumor necrosis factor biosynthetic process(GO:0042536)
0.0	0.1	GO:0071257	cellular response to electrical stimulus(GO:0071257)
0.0	0.1	GO:0035280	miRNA loading onto RISC involved in gene silencing by miRNA(GO:0035280)
0.0	0.2	GO:0009813	flavonoid biosynthetic process(GO:0009813) flavonoid glucuronidation(GO:0052696)
0.0	0.0	GO:1901069	guanosine-containing compound catabolic process(GO:1901069)
0.0	0.1	GO:0006004	fucose metabolic process(GO:0006004)
0.0	0.1	GO:1902170	cellular response to reactive nitrogen species(GO:1902170)
0.0	0.1	GO:0070493	thrombin receptor signaling pathway(GO:0070493)
0.0	0.0	GO:0061113	pancreas morphogenesis(GO:0061113)
0.0	0.1	GO:0090286	cytoskeletal anchoring at nuclear membrane(GO:0090286)
0.0	0.1	GO:0097094	craniofacial suture morphogenesis(GO:0097094)
0.0	0.3	GO:0042755	eating behavior(GO:0042755)
0.0	0.0	GO:1900019	regulation of protein kinase C activity(GO:1900019) positive regulation of protein kinase C activity(GO:1900020)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.7	GO:0042406	extrinsic component of endoplasmic reticulum membrane(GO:0042406)
0.1	0.3	GO:0070937	CRD-mediated mRNA stability complex(GO:0070937)
0.1	0.2	GO:0060053	neurofilament cytoskeleton(GO:0060053)
0.0	0.5	GO:0046581	intercellular canaliculus(GO:0046581)
0.0	0.2	GO:0031315	extrinsic component of mitochondrial outer membrane(GO:0031315)
0.0	0.5	GO:0000177	cytoplasmic exosome (RNase complex)(GO:0000177)
0.0	0.2	GO:0042587	glycogen granule(GO:0042587)
0.0	0.1	GO:0008622	epsilon DNA polymerase complex(GO:0008622)
0.0	0.1	GO:1990604	IRE1-TRAF2-ASK1 complex(GO:1990604)
0.0	0.3	GO:0042612	MHC class I protein complex(GO:0042612)
0.0	0.1	GO:0070419	nonhomologous end joining complex(GO:0070419)
0.0	0.1	GO:0031262	Ndc80 complex(GO:0031262)
0.0	0.1	GO:0033269	internode region of axon(GO:0033269)
0.0	0.2	GO:0031235	intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.0	0.1	GO:0010009	cytoplasmic side of endosome membrane(GO:0010009)
0.0	0.1	GO:0034666	integrin alpha2-beta1 complex(GO:0034666)
0.0	0.1	GO:0005577	fibrinogen complex(GO:0005577)
0.0	0.1	GO:0000138	Golgi trans cisterna(GO:0000138)
0.0	0.1	GO:0097443	sorting endosome(GO:0097443)
0.0	0.0	GO:0035985	senescence-associated heterochromatin focus(GO:0035985)
0.0	0.1	GO:0097524	sperm plasma membrane(GO:0097524)
0.0	0.3	GO:0031907	peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.0	0.1	GO:0042382	paraspeckles(GO:0042382)
0.0	0.2	GO:0033391	chromatoid body(GO:0033391)
0.0	0.1	GO:0034363	intermediate-density lipoprotein particle(GO:0034363)
0.0	0.0	GO:0034750	Scrib-APC-beta-catenin complex(GO:0034750)
0.0	0.1	GO:0033063	Rad51B-Rad51C-Rad51D-XRCC2 complex(GO:0033063)
0.0	0.0	GO:0097058	CRLF-CLCF1 complex(GO:0097058)
0.0	0.1	GO:0031258	lamellipodium membrane(GO:0031258)
0.0	0.1	GO:0032021	NELF complex(GO:0032021)
0.0	0.1	GO:0005786	signal recognition particle, endoplasmic reticulum targeting(GO:0005786) signal recognition particle(GO:0048500)
0.0	0.1	GO:0033180	proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.0	0.1	GO:0005779	integral component of peroxisomal membrane(GO:0005779)
0.0	0.2	GO:0031307	integral component of mitochondrial outer membrane(GO:0031307)
0.0	0.2	GO:0000145	exocyst(GO:0000145)
0.0	0.2	GO:0001741	XY body(GO:0001741)
0.0	0.1	GO:0060091	kinocilium(GO:0060091)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:0005345	purine nucleobase transmembrane transporter activity(GO:0005345) pyrimidine nucleobase transmembrane transporter activity(GO:0005350) nucleobase transmembrane transporter activity(GO:0015205)
0.1	0.2	GO:0031871	proteinase activated receptor binding(GO:0031871)
0.1	0.2	GO:0004427	inorganic diphosphatase activity(GO:0004427)
0.1	0.2	GO:0008525	phosphatidylcholine transporter activity(GO:0008525)
0.1	0.2	GO:0008142	oxysterol binding(GO:0008142)
0.1	0.2	GO:0003886	DNA (cytosine-5-)-methyltransferase activity(GO:0003886) DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates(GO:0051718)
0.0	0.4	GO:0050649	testosterone 6-beta-hydroxylase activity(GO:0050649)
0.0	0.4	GO:0034046	poly(G) binding(GO:0034046)
0.0	0.2	GO:0030151	molybdenum ion binding(GO:0030151)
0.0	0.2	GO:0034902	alkyl sulfatase activity(GO:0018741) endosulfan hemisulfate sulfatase activity(GO:0034889) endosulfan sulfate hydrolase activity(GO:0034902)
0.0	0.1	GO:0015252	hydrogen ion channel activity(GO:0015252)
0.0	0.4	GO:0008191	metalloendopeptidase inhibitor activity(GO:0008191)
0.0	0.1	GO:0004505	phenylalanine 4-monooxygenase activity(GO:0004505)
0.0	0.6	GO:0003746	translation elongation factor activity(GO:0003746)
0.0	0.1	GO:0000268	peroxisome targeting sequence binding(GO:0000268)
0.0	0.1	GO:0004792	thiosulfate sulfurtransferase activity(GO:0004792)
0.0	0.1	GO:0003840	gamma-glutamyltransferase activity(GO:0003840) glutathione hydrolase activity(GO:0036374)
0.0	0.1	GO:0008559	xenobiotic-transporting ATPase activity(GO:0008559)
0.0	0.1	GO:1990715	mRNA CDS binding(GO:1990715)
0.0	0.2	GO:0030274	LIM domain binding(GO:0030274)
0.0	0.1	GO:0004528	phosphodiesterase I activity(GO:0004528)
0.0	0.3	GO:0004185	serine-type carboxypeptidase activity(GO:0004185)
0.0	0.1	GO:0008384	IkappaB kinase activity(GO:0008384)
0.0	0.1	GO:0016647	oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor(GO:0016647)
0.0	0.1	GO:0017098	sulfonylurea receptor binding(GO:0017098)
0.0	0.1	GO:0004731	purine-nucleoside phosphorylase activity(GO:0004731)
0.0	0.3	GO:0030881	beta-2-microglobulin binding(GO:0030881)
0.0	0.1	GO:0061505	DNA topoisomerase type II (ATP-hydrolyzing) activity(GO:0003918) DNA topoisomerase II activity(GO:0061505)
0.0	0.1	GO:0016716	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen(GO:0016716)
0.0	0.2	GO:0031957	very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.0	0.1	GO:0008970	phosphatidylcholine 1-acylhydrolase activity(GO:0008970)
0.0	0.1	GO:0009374	biotin binding(GO:0009374)
0.0	0.1	GO:0042392	sphingosine-1-phosphate phosphatase activity(GO:0042392)
0.0	0.1	GO:0003986	acetyl-CoA hydrolase activity(GO:0003986)
0.0	0.1	GO:0016823	hydrolase activity, acting on acid carbon-carbon bonds(GO:0016822) hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances(GO:0016823)
0.0	0.2	GO:0008429	phosphatidylethanolamine binding(GO:0008429)
0.0	0.1	GO:0031013	troponin I binding(GO:0031013)
0.0	0.1	GO:0016838	carbon-oxygen lyase activity, acting on phosphates(GO:0016838)
0.0	0.1	GO:0015198	oligopeptide transporter activity(GO:0015198)
0.0	0.1	GO:0004740	pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740)
0.0	0.2	GO:0070513	death domain binding(GO:0070513)
0.0	0.1	GO:0004920	interleukin-10 receptor activity(GO:0004920)
0.0	0.1	GO:0030899	calcium-dependent ATPase activity(GO:0030899)
0.0	0.2	GO:0005068	transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
0.0	0.1	GO:0004769	steroid delta-isomerase activity(GO:0004769)
0.0	0.0	GO:0004346	glucose-6-phosphatase activity(GO:0004346) sugar-terminal-phosphatase activity(GO:0050309)
0.0	0.1	GO:0008131	primary amine oxidase activity(GO:0008131)
0.0	0.1	GO:0008312	7S RNA binding(GO:0008312)
0.0	0.1	GO:0005499	vitamin D binding(GO:0005499)
0.0	0.1	GO:0035312	5'-3' exodeoxyribonuclease activity(GO:0035312)
0.0	0.0	GO:0000253	3-keto sterol reductase activity(GO:0000253)
0.0	0.0	GO:0046573	lactonohydrolase activity(GO:0046573) acyl-L-homoserine-lactone lactonohydrolase activity(GO:0102007)
0.0	0.1	GO:0051525	NFAT protein binding(GO:0051525)
0.0	0.0	GO:0017153	sodium:dicarboxylate symporter activity(GO:0017153)
0.0	0.1	GO:0031750	D3 dopamine receptor binding(GO:0031750)
0.0	0.1	GO:0019960	C-X3-C chemokine binding(GO:0019960)
0.0	0.1	GO:0005095	GTPase inhibitor activity(GO:0005095)
0.0	0.1	GO:0000405	bubble DNA binding(GO:0000405)
0.0	0.1	GO:0004165	dodecenoyl-CoA delta-isomerase activity(GO:0004165)
0.0	0.0	GO:0050692	DBD domain binding(GO:0050692)
0.0	0.0	GO:0034988	Fc-gamma receptor I complex binding(GO:0034988)
0.0	0.1	GO:0070097	delta-catenin binding(GO:0070097)
0.0	0.1	GO:0001846	opsonin binding(GO:0001846)
0.0	0.0	GO:0019961	interferon binding(GO:0019961)
0.0	0.0	GO:0050833	pyruvate transmembrane transporter activity(GO:0050833)
0.0	0.0	GO:0004833	tryptophan 2,3-dioxygenase activity(GO:0004833)
0.0	0.1	GO:0008410	CoA-transferase activity(GO:0008410)
0.0	0.0	GO:0019776	Atg8 ligase activity(GO:0019776)
0.0	0.0	GO:0016018	cyclosporin A binding(GO:0016018)
0.0	0.1	GO:1990226	histone methyltransferase binding(GO:1990226)
0.0	0.1	GO:0015129	lactate transmembrane transporter activity(GO:0015129)
0.0	0.1	GO:0038085	vascular endothelial growth factor binding(GO:0038085)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.1	PID IL5 PATHWAY	IL5-mediated signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Total log-likelihood	Term	Description
0.2	REACTOME BETA DEFENSINS	Genes involved in Beta defensins
0.3	REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS	Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.3	REACTOME PASSIVE TRANSPORT BY AQUAPORINS	Genes involved in Passive Transport by Aquaporins
0.0	REACTOME CTLA4 INHIBITORY SIGNALING	Genes involved in CTLA4 inhibitory signaling
0.4	REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT	Genes involved in Chylomicron-mediated lipid transport
0.2	REACTOME ERKS ARE INACTIVATED	Genes involved in ERKs are inactivated
0.0	REACTOME PLATELET SENSITIZATION BY LDL	Genes involved in Platelet sensitization by LDL
0.2	REACTOME GLUCURONIDATION	Genes involved in Glucuronidation
0.1	REACTOME THE ACTIVATION OF ARYLSULFATASES	Genes involved in The activation of arylsulfatases
0.2	REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24 HYDROXYCHOLESTEROL	Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol
0.1	REACTOME RNA POL I PROMOTER OPENING	Genes involved in RNA Polymerase I Promoter Opening
0.3	REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA	Genes involved in Circadian Repression of Expression by REV-ERBA
0.2	REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY	Genes involved in Post-chaperonin tubulin folding pathway
0.3	REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE	Genes involved in Sema4D induced cell migration and growth-cone collapse
0.0	REACTOME MRNA CAPPING	Genes involved in mRNA Capping
0.1	REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP	Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.1	REACTOME COPI MEDIATED TRANSPORT	Genes involved in COPI Mediated Transport