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ENCSR904DTN: DNase-seq of mouse liver in constant darkness

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Results for Prdm1

Z-value: 1.86

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Transcription factors associated with Prdm1

Gene Symbol	Gene ID	Gene Info
Prdm1 Ensembl NCBI MGI UniProt	ENSMUSG00000038151.6	PR domain containing 1, with ZNF domain

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
chr10_44454950_44455114	Prdm1	2178	0.316618	0.71	1.2e-01	Click!
chr10_44474418_44474575	Prdm1	15748	0.184920	0.58	2.2e-01	Click!
chr10_44481546_44481706	Prdm1	22878	0.169199	0.47	3.4e-01	Click!
chr10_44455197_44455348	Prdm1	1938	0.343142	-0.39	4.5e-01	Click!
chr10_44447565_44447742	Prdm1	9557	0.192420	0.35	4.9e-01	Click!

Activity of the Prdm1 motif across conditions

Conditions sorted by the z-value of the Prdm1 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr3_145775927_145776137	1.12	Ddah1	dimethylarginine dimethylaminohydrolase 1	15284	0.2
chr18_7657901_7658087	1.10	Mpp7	membrane protein, palmitoylated 7 (MAGUK p55 subfamily member 7)	31128	0.17
chr19_26823384_26823535	0.93	4931403E22Rik	RIKEN cDNA 4931403E22 gene	448	0.84
chr11_5905326_5905477	0.79	Gck	glucokinase	3314	0.14
chr3_96883833_96883984	0.78	Gpr89	G protein-coupled receptor 89	7700	0.13
chr7_84457901_84458052	0.74	Gm45175	predicted gene 45175	13425	0.16
chr7_72323573_72323742	0.71	Mctp2	multiple C2 domains, transmembrane 2	17049	0.28
chr6_117577757_117577908	0.65	Gm9946	predicted gene 9946	10160	0.2
chr1_178600841_178601326	0.64	Gm24405	predicted gene, 24405	35822	0.18
chr13_41386761_41386912	0.62	Gm48571	predicted gene, 48571	6880	0.15
chr6_43850496_43850673	0.60	Gm7783	predicted gene 7783	6320	0.26
chr15_3468057_3468222	0.59	Ghr	growth hormone receptor	3505	0.35
chr11_16528502_16528653	0.58	Akt2-ps	thymoma viral proto-oncogene 2, pseudogene	14044	0.2
chr9_74892937_74893252	0.58	Onecut1	one cut domain, family member 1	26610	0.14
chr6_121171179_121171645	0.58	Pex26	peroxisomal biogenesis factor 26	12255	0.13
chr3_111344475_111344661	0.57	Gm9314	predicted gene 9314	21711	0.29
chr2_21117164_21117329	0.57	Gm13376	predicted gene 13376	20147	0.17
chr13_112902308_112902475	0.55	Mtrex	Mtr4 exosome RNA helicase	15283	0.12
chr3_69139928_69140109	0.55	Gm1647	predicted gene 1647	8785	0.14
chr12_104342354_104343298	0.54	Serpina3k	serine (or cysteine) peptidase inhibitor, clade A, member 3K	4340	0.13
chr9_114621205_114621361	0.54	Cnot10	CCR4-NOT transcription complex, subunit 10	18680	0.14
chr11_88926781_88926936	0.54	Scpep1os	serine carboxypeptidase 1, opposite strand	20930	0.1
chr15_37998302_37998493	0.53	Ubr5	ubiquitin protein ligase E3 component n-recognin 5	1730	0.31
chr16_4211280_4211431	0.52	Crebbp	CREB binding protein	2058	0.29
chr2_134502496_134502663	0.52	Hao1	hydroxyacid oxidase 1, liver	51728	0.18
chr6_145863813_145864067	0.51	Gm43909	predicted gene, 43909	643	0.6
chr4_148616552_148616759	0.50	Tardbp	TAR DNA binding protein	325	0.81
chr9_71694307_71694467	0.49	Cgnl1	cingulin-like 1	46037	0.14
chr8_128078877_128079030	0.48	Mir21c	microRNA 21c	199272	0.03
chr11_26413799_26413986	0.48	Gm12713	predicted gene 12713	4685	0.26
chr12_30344893_30345053	0.48	Sntg2	syntrophin, gamma 2	12710	0.25
chr19_36932520_36932671	0.47	Btaf1	B-TFIID TATA-box binding protein associated factor 1	6516	0.21
chr10_68137101_68137496	0.47	Arid5b	AT rich interactive domain 5B (MRF1-like)	672	0.78
chr1_182100464_182100642	0.47	Srp9	signal recognition particle 9	24184	0.13
chr16_34921418_34921569	0.46	Mylk	myosin, light polypeptide kinase	8849	0.19
chr3_107238884_107239100	0.46	Prok1	prokineticin 1	340	0.83
chr1_69634374_69634531	0.45	Gm28112	predicted gene 28112	27609	0.17
chr17_63181800_63181984	0.45	Gm24730	predicted gene, 24730	20846	0.24
chr11_80103009_80103182	0.45	Atad5	ATPase family, AAA domain containing 5	92	0.96
chr16_43169614_43169782	0.44	Gm15712	predicted gene 15712	14875	0.21
chr11_16900094_16900245	0.44	Egfr	epidermal growth factor receptor	5016	0.22
chr12_80932956_80933128	0.44	1700052I22Rik	RIKEN cDNA 1700052I22 gene	8593	0.13
chr6_72000258_72000422	0.44	Gm26628	predicted gene, 26628	36565	0.1
chr9_74304589_74304740	0.43	Wdr72	WD repeat domain 72	30530	0.19
chr19_38419073_38419264	0.43	Slc35g1	solute carrier family 35, member G1	23127	0.14
chr3_52458834_52458985	0.43	Gm38098	predicted gene, 38098	33501	0.17
chr12_69768209_69768388	0.42	Mir681	microRNA 681	4354	0.15
chr2_134853625_134853800	0.42	Gm14036	predicted gene 14036	49763	0.15
chr12_104082595_104082890	0.42	Serpina4-ps1	serine (or cysteine) peptidase inhibitor, clade A, member 4, pseudogene 1	2093	0.18
chr7_79275538_79275706	0.41	Gm44639	predicted gene 44639	2145	0.2
chr16_49775651_49775805	0.41	Gm15518	predicted gene 15518	23142	0.2
chr12_110044398_110044582	0.41	Gm47187	predicted gene, 47187	17780	0.11
chr4_6262292_6262457	0.41	Gm11798	predicted gene 11798	1409	0.43
chr3_79994302_79994453	0.41	A330069K06Rik	RIKEN cDNA A330069K06 gene	60515	0.11
chr5_151018980_151019139	0.41	Gm8675	predicted gene 8675	9758	0.23
chr4_3751092_3751243	0.40	Lyn	LYN proto-oncogene, Src family tyrosine kinase	5290	0.17
chr2_70666883_70667034	0.40	Gorasp2	golgi reassembly stacking protein 2	4758	0.18
chr2_122255801_122256080	0.40	Sord	sorbitol dehydrogenase	21191	0.09
chr17_6867831_6868002	0.40	Mir692-1	microRNA 692-1	27421	0.12
chr17_57198725_57198876	0.40	Tnfsf14	tumor necrosis factor (ligand) superfamily, member 14	4623	0.13
chr1_39368822_39369001	0.40	Rpl31	ribosomal protein L31	762	0.58
chr1_21829923_21830095	0.39	Gm38243	predicted gene, 38243	10505	0.24
chr2_52613475_52613626	0.39	Bloc1s2-ps	biogenesis of lysosomal organelles complex-1, subunit 2, pseudogene	6204	0.24
chr6_95018081_95018258	0.39	4930511E03Rik	RIKEN cDNA 4930511E03 gene	74335	0.09
chr15_59141725_59141916	0.39	Mtss1	MTSS I-BAR domain containing 1	59815	0.11
chr4_155071078_155071229	0.39	Pex10	peroxisomal biogenesis factor 10	4094	0.15
chr2_24040580_24040761	0.38	Hnmt	histamine N-methyltransferase	8196	0.23
chr6_23080148_23080299	0.38	Ptprz1	protein tyrosine phosphatase, receptor type Z, polypeptide 1	31951	0.15
chr12_103991999_103992602	0.38	Serpina11	serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 11	2343	0.16
chr10_121571625_121571789	0.38	Tbk1	TANK-binding kinase 1	3226	0.18
chr11_55468108_55468290	0.38	G3bp1	GTPase activating protein (SH3 domain) binding protein 1	1486	0.25
chr13_74505877_74506069	0.38	Gm49763	predicted gene, 49763	11830	0.1
chr5_90315666_90315817	0.37	Ankrd17	ankyrin repeat domain 17	11637	0.21
chr5_51539672_51539839	0.37	Ppargc1a	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	14116	0.17
chr7_71232911_71233088	0.37	6030442E23Rik	RIKEN cDNA 6030442E23 gene	15950	0.2
chr14_7832222_7832456	0.37	Flnb	filamin, beta	14382	0.16
chr18_14825706_14825857	0.36	Gm21055	predicted gene, 21055	4887	0.25
chr1_172590517_172590678	0.36	Slamf8	SLAM family member 8	29	0.96
chr19_55793163_55793324	0.36	Ppnr	per-pentamer repeat gene	48429	0.16
chr4_3373115_3373279	0.36	Gm11784	predicted gene 11784	13649	0.2
chr9_122848440_122848788	0.36	Gm47140	predicted gene, 47140	196	0.89
chr7_4655984_4656315	0.36	Gm44878	predicted gene 44878	2511	0.11
chr15_53724232_53724383	0.35	1700015H07Rik	RIKEN cDNA 1700015H07 gene	102652	0.07
chr17_86150939_86151254	0.35	Srbd1	S1 RNA binding domain 1	5921	0.21
chr16_56038236_56038391	0.35	Trmt10c	tRNA methyltransferase 10C, mitochondrial RNase P subunit	494	0.65
chr3_83663805_83664183	0.35	Rpl28-ps2	ribosomal protein L28, pseudogene 2	22727	0.19
chr8_76540217_76540646	0.35	Gm27355	predicted gene, 27355	78851	0.1
chr3_98743356_98743926	0.35	Hsd3b3	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 3	9824	0.13
chr4_49542856_49543140	0.35	Aldob	aldolase B, fructose-bisphosphate	3112	0.18
chr14_116240919_116241084	0.34	Gm20713	predicted gene 20713	369723	0.01
chr4_3724826_3724987	0.34	Gm11805	predicted gene 11805	3880	0.2
chr14_95884398_95884549	0.34	Spertl	spermatid associated like	3207	0.33
chr6_146903752_146903913	0.34	Ppfibp1	PTPRF interacting protein, binding protein 1 (liprin beta 1)	15243	0.15
chr6_114879701_114879922	0.34	Vgll4	vestigial like family member 4	4704	0.23
chr5_100557088_100557255	0.34	Plac8	placenta-specific 8	5687	0.14
chr6_38506694_38506867	0.34	Mir7670	microRNA 7670	545	0.71
chr3_30105629_30105802	0.34	Mecom	MDS1 and EVI1 complex locus	34708	0.17
chr16_21836755_21836930	0.34	Gm49607	predicted gene, 49607	287	0.85
chr11_16777068_16777446	0.33	Egfr	epidermal growth factor receptor	25027	0.17
chr9_71175821_71176011	0.33	Gm32511	predicted gene, 32511	7140	0.18
chr13_81330589_81330889	0.33	Adgrv1	adhesion G protein-coupled receptor V1	12097	0.26
chr2_109714999_109715174	0.32	Bdnf	brain derived neurotrophic factor	5703	0.22
chr12_118296347_118296498	0.32	Sp4	trans-acting transcription factor 4	4946	0.29
chr3_18157205_18157356	0.32	Gm23686	predicted gene, 23686	20345	0.21
chr18_84210867_84211018	0.32	Gm50311	predicted gene, 50311	8018	0.25
chr14_66027915_66028101	0.32	Gm10233	predicted pseudogene 10233	17072	0.14
chr8_84650202_84650366	0.32	Cacna1a	calcium channel, voltage-dependent, P/Q type, alpha 1A subunit	11293	0.1
chr6_54465003_54465192	0.32	Wipf3	WAS/WASL interacting protein family, member 3	6905	0.17
chr1_177794963_177795127	0.32	Adss	adenylosuccinate synthetase, non muscle	1456	0.38
chr9_55281590_55281872	0.32	Nrg4	neuregulin 4	1841	0.33
chr6_38868049_38868218	0.32	Tbxas1	thromboxane A synthase 1, platelet	7271	0.21
chr11_46309219_46309377	0.31	Cyfip2	cytoplasmic FMR1 interacting protein 2	2922	0.22
chr11_54413058_54413209	0.31	Gm12225	predicted gene 12225	8993	0.13
chr7_130059814_130059979	0.31	Gm23847	predicted gene, 23847	24802	0.24
chr8_14996937_14997102	0.31	Arhgef10	Rho guanine nucleotide exchange factor (GEF) 10	883	0.45
chr2_114610179_114610347	0.31	Gm13972	predicted gene 13972	44162	0.16
chr19_37213872_37214035	0.31	Marchf5	membrane associated ring-CH-type finger 5	3237	0.17
chr17_42887528_42887679	0.31	Cd2ap	CD2-associated protein	10938	0.28
chr6_120917276_120917440	0.31	Bid	BH3 interacting domain death agonist	505	0.67
chr17_8343757_8343973	0.31	Prr18	proline rich 18	3126	0.15
chr9_65809859_65810043	0.31	Zfp609	zinc finger protein 609	12039	0.14
chr3_95324812_95324966	0.31	Cers2	ceramide synthase 2	3949	0.1
chr18_43129253_43129421	0.31	Gm8181	predicted gene 8181	41822	0.12
chr8_11622585_11622761	0.30	Ankrd10	ankyrin repeat domain 10	1953	0.2
chr8_77241292_77241473	0.30	Gm45406	predicted gene 45406	41479	0.13
chr5_100418951_100419124	0.30	Sec31a	Sec31 homolog A (S. cerevisiae)	2803	0.2
chr11_25838781_25838932	0.30	5730522E02Rik	RIKEN cDNA 5730522E02 gene	69715	0.13
chr2_118448093_118448276	0.30	Eif2ak4	eukaryotic translation initiation factor 2 alpha kinase 4	8976	0.16
chr15_53168686_53168859	0.30	Ext1	exostosin glycosyltransferase 1	27483	0.26
chr14_13625050_13625231	0.30	Sntn	sentan, cilia apical structure protein	45736	0.17
chr13_62866069_62866220	0.30	Fbp1	fructose bisphosphatase 1	6614	0.13
chr1_62719851_62720045	0.30	Gm29083	predicted gene 29083	1875	0.33
chr5_4024477_4024646	0.30	Akap9	A kinase (PRKA) anchor protein (yotiao) 9	1146	0.5
chr5_98992026_98992185	0.30	Prkg2	protein kinase, cGMP-dependent, type II	25349	0.2
chr10_94545587_94545808	0.30	Tmcc3	transmembrane and coiled coil domains 3	266	0.92
chr8_86735912_86736063	0.30	Gm10638	predicted gene 10638	9466	0.17
chr10_90273418_90273600	0.30	Gm5780	predicted gene 5780	138692	0.05
chr1_157247495_157247658	0.29	Rasal2	RAS protein activator like 2	3086	0.3
chr2_163670938_163671176	0.29	Pkig	protein kinase inhibitor, gamma	9558	0.13
chr6_134544187_134544824	0.29	Lrp6	low density lipoprotein receptor-related protein 6	2791	0.27
chr8_46499145_46499431	0.29	Acsl1	acyl-CoA synthetase long-chain family member 1	6456	0.17
chr18_65837283_65837437	0.29	Gm50174	predicted gene, 50174	73	0.94
chr11_16913067_16913239	0.29	Egfr	epidermal growth factor receptor	7968	0.19
chr6_51458240_51458453	0.29	Hnrnpa2b1	heterogeneous nuclear ribonucleoprotein A2/B1	4838	0.18
chr12_58214814_58214997	0.29	Sstr1	somatostatin receptor 1	3101	0.36
chr17_28437280_28437431	0.29	Fkbp5	FK506 binding protein 5	3655	0.13
chr2_72114198_72114385	0.29	Rapgef4	Rap guanine nucleotide exchange factor (GEF) 4	26420	0.18
chr14_17695082_17695233	0.29	Thrb	thyroid hormone receptor beta	34261	0.22
chr11_16769725_16769905	0.29	Egfr	epidermal growth factor receptor	17585	0.19
chrX_48054599_48054771	0.29	Apln	apelin	19832	0.2
chr15_39111986_39112168	0.29	Slc25a32	solute carrier family 25, member 32	555	0.51
chr16_95579480_95579639	0.29	Erg	ETS transcription factor	7034	0.29
chr11_118211857_118212019	0.29	Cyth1	cytohesin 1	804	0.57
chr2_38108700_38108871	0.28	Gm44291	predicted gene, 44291	1489	0.45
chr19_58421265_58421439	0.28	Gfra1	glial cell line derived neurotrophic factor family receptor alpha 1	33114	0.19
chr10_121501382_121501572	0.28	Gm46204	predicted gene, 46204	3874	0.13
chr4_70521535_70521760	0.28	Megf9	multiple EGF-like-domains 9	13281	0.3
chr15_85675723_85675883	0.28	Lncppara	long noncoding RNA near Ppara	22187	0.12
chr10_79769428_79769606	0.28	Rnf126	ring finger protein 126	2565	0.11
chr10_120015234_120015396	0.28	Grip1	glutamate receptor interacting protein 1	22209	0.22
chr2_121439848_121440228	0.28	Ell3	elongation factor RNA polymerase II-like 3	1113	0.25
chr9_105746936_105747087	0.28	Gm38314	predicted gene, 38314	19226	0.18
chr18_36571831_36571982	0.28	Ankhd1	ankyrin repeat and KH domain containing 1	9171	0.13
chr1_9578333_9578671	0.28	Gm6161	predicted gene 6161	3954	0.16
chr8_125346149_125346401	0.28	Gm16237	predicted gene 16237	118952	0.06
chr3_66122973_66123139	0.28	Tpi-rs2	triosephosphate isomerase related sequence 2	6667	0.14
chr4_84540692_84540849	0.28	Bnc2	basonuclin 2	5520	0.32
chr10_87920381_87920532	0.28	Tyms-ps	thymidylate synthase, pseudogene	46391	0.12
chr10_123118441_123118756	0.28	Usp15	ubiquitin specific peptidase 15	883	0.61
chr19_22642267_22642418	0.28	Trpm3	transient receptor potential cation channel, subfamily M, member 3	50259	0.17
chr14_11691642_11691807	0.28	Gm48602	predicted gene, 48602	76219	0.1
chr4_150427704_150427878	0.27	Rere	arginine glutamic acid dipeptide (RE) repeats	21397	0.21
chr6_141655199_141655350	0.27	Slco1b2	solute carrier organic anion transporter family, member 1b2	3019	0.35
chr1_191180455_191180648	0.27	Atf3	activating transcription factor 3	2557	0.2
chr16_52416810_52416986	0.27	Alcam	activated leukocyte cell adhesion molecule	35567	0.23
chr4_108055323_108055845	0.27	Scp2	sterol carrier protein 2, liver	7705	0.14
chr8_78031019_78031191	0.27	Gm29895	predicted gene, 29895	12905	0.26
chr14_12072661_12072824	0.27	Ptprg	protein tyrosine phosphatase, receptor type, G	18418	0.23
chr4_46863636_46863790	0.27	Gabbr2	gamma-aminobutyric acid (GABA) B receptor, 2	3811	0.32
chr15_53297534_53297744	0.27	Ext1	exostosin glycosyltransferase 1	48020	0.18
chr10_127632738_127633305	0.27	Gm48815	predicted gene, 48815	3366	0.11
chr11_16902546_16902715	0.27	Egfr	epidermal growth factor receptor	2555	0.28
chr8_114152687_114152971	0.27	Nudt7	nudix (nucleoside diphosphate linked moiety X)-type motif 7	19187	0.25
chr13_38090008_38090167	0.27	Gm27387	predicted gene, 27387	3885	0.2
chr10_38970068_38970231	0.27	Lama4	laminin, alpha 4	4477	0.27
chr9_21969411_21969573	0.27	Rgl3	ral guanine nucleotide dissociation stimulator-like 3	4791	0.09
chr12_69513282_69513448	0.27	5830428M24Rik	RIKEN cDNA 5830428M24 gene	37815	0.11
chr2_48333003_48333182	0.27	Gm13482	predicted gene 13482	34184	0.18
chr10_39417755_39417908	0.27	Fyn	Fyn proto-oncogene	2178	0.32
chr13_4468002_4468176	0.27	Gm48010	predicted gene, 48010	1523	0.38
chr14_34488757_34488916	0.26	Gm17110	predicted gene 17110	12879	0.13
chr16_91441296_91441472	0.26	Gm46562	predicted gene, 46562	17037	0.09
chr13_80890366_80890663	0.26	Arrdc3	arrestin domain containing 3	4	0.97
chr6_11961160_11961311	0.26	Phf14	PHD finger protein 14	25829	0.23
chr11_100526464_100526691	0.26	Acly	ATP citrate lyase	1292	0.28
chr2_145704854_145705052	0.26	Gm11763	predicted gene 11763	3228	0.26
chr4_135989135_135989286	0.26	Pithd1	PITH (C-terminal proteasome-interacting domain of thioredoxin-like) domain containing 1	1946	0.16
chr10_69923910_69924142	0.26	Ank3	ankyrin 3, epithelial	1469	0.57
chr16_31705299_31705479	0.26	Dlg1	discs large MAGUK scaffold protein 1	21123	0.13
chr10_4105736_4105887	0.26	Gm25515	predicted gene, 25515	1498	0.45

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of Prdm1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	0.5	GO:1903800	positive regulation of production of miRNAs involved in gene silencing by miRNA(GO:1903800)
0.1	0.7	GO:0060613	fat pad development(GO:0060613)
0.1	0.3	GO:0015014	heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0015014)
0.1	0.2	GO:0006701	progesterone biosynthetic process(GO:0006701)
0.1	0.5	GO:0071763	nuclear membrane organization(GO:0071763)
0.1	0.2	GO:1900825	regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900825)
0.1	0.2	GO:0034196	acylglycerol transport(GO:0034196) triglyceride transport(GO:0034197)
0.1	0.3	GO:0072338	creatinine metabolic process(GO:0046449) cellular lactam metabolic process(GO:0072338)
0.1	0.3	GO:0045900	negative regulation of translational elongation(GO:0045900)
0.1	0.1	GO:0045608	negative regulation of auditory receptor cell differentiation(GO:0045608)
0.1	0.2	GO:1902915	negative regulation of protein K63-linked ubiquitination(GO:1900045) negative regulation of protein polyubiquitination(GO:1902915)
0.1	0.1	GO:2000586	regulation of platelet-derived growth factor receptor-beta signaling pathway(GO:2000586) negative regulation of platelet-derived growth factor receptor-beta signaling pathway(GO:2000587)
0.1	0.4	GO:0033860	regulation of NAD(P)H oxidase activity(GO:0033860)
0.1	0.2	GO:1904479	negative regulation of intestinal absorption(GO:1904479)
0.1	0.2	GO:0071286	cellular response to magnesium ion(GO:0071286)
0.1	0.2	GO:0060523	prostate epithelial cord elongation(GO:0060523)
0.1	0.2	GO:0061113	pancreas morphogenesis(GO:0061113)
0.1	0.1	GO:0003213	cardiac right atrium morphogenesis(GO:0003213)
0.1	0.2	GO:0034136	negative regulation of toll-like receptor 2 signaling pathway(GO:0034136)
0.1	0.2	GO:2000346	negative regulation of hepatocyte proliferation(GO:2000346)
0.1	0.2	GO:0071896	protein localization to adherens junction(GO:0071896)
0.1	0.2	GO:0003219	cardiac right ventricle formation(GO:0003219)
0.0	0.2	GO:0000966	RNA 5'-end processing(GO:0000966)
0.0	0.1	GO:0034287	detection of carbohydrate stimulus(GO:0009730) detection of hexose stimulus(GO:0009732) detection of monosaccharide stimulus(GO:0034287) detection of glucose(GO:0051594)
0.0	0.4	GO:0048304	positive regulation of isotype switching to IgG isotypes(GO:0048304)
0.0	0.1	GO:0018894	dibenzo-p-dioxin metabolic process(GO:0018894)
0.0	0.2	GO:0032020	ISG15-protein conjugation(GO:0032020)
0.0	0.2	GO:0048625	myoblast fate commitment(GO:0048625)
0.0	0.1	GO:0001692	histamine metabolic process(GO:0001692)
0.0	0.2	GO:0032819	positive regulation of natural killer cell proliferation(GO:0032819)
0.0	0.2	GO:0006083	acetate metabolic process(GO:0006083)
0.0	0.1	GO:1900245	positive regulation of MDA-5 signaling pathway(GO:1900245)
0.0	0.1	GO:0019086	late viral transcription(GO:0019086)
0.0	0.1	GO:0038161	prolactin signaling pathway(GO:0038161)
0.0	0.1	GO:1900169	regulation of glucocorticoid mediated signaling pathway(GO:1900169)
0.0	0.1	GO:0042505	tyrosine phosphorylation of Stat6 protein(GO:0042505) regulation of tyrosine phosphorylation of Stat6 protein(GO:0042525)
0.0	0.1	GO:0032483	regulation of Rab protein signal transduction(GO:0032483)
0.0	0.1	GO:0033091	positive regulation of immature T cell proliferation(GO:0033091)
0.0	0.1	GO:0046208	spermine catabolic process(GO:0046208)
0.0	0.2	GO:0019262	N-acetylneuraminate catabolic process(GO:0019262)
0.0	0.1	GO:2000259	positive regulation of complement activation(GO:0045917) positive regulation of protein activation cascade(GO:2000259)
0.0	0.1	GO:1904694	negative regulation of vascular smooth muscle contraction(GO:1904694)
0.0	0.1	GO:0032687	negative regulation of interferon-alpha production(GO:0032687)
0.0	0.2	GO:0045541	negative regulation of cholesterol biosynthetic process(GO:0045541) negative regulation of cholesterol metabolic process(GO:0090206)
0.0	0.1	GO:0038165	oncostatin-M-mediated signaling pathway(GO:0038165)
0.0	0.2	GO:0060355	positive regulation of cell adhesion molecule production(GO:0060355)
0.0	0.2	GO:0061087	positive regulation of histone H3-K27 methylation(GO:0061087)
0.0	0.2	GO:2001197	regulation of basement membrane assembly involved in embryonic body morphogenesis(GO:1904259) positive regulation of basement membrane assembly involved in embryonic body morphogenesis(GO:1904261) basement membrane assembly involved in embryonic body morphogenesis(GO:2001197)
0.0	0.1	GO:1901475	pyruvate transmembrane transport(GO:1901475)
0.0	0.1	GO:0035865	response to potassium ion(GO:0035864) cellular response to potassium ion(GO:0035865)
0.0	0.2	GO:0006686	sphingomyelin biosynthetic process(GO:0006686)
0.0	0.1	GO:0036091	positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress(GO:0036091)
0.0	0.1	GO:2000566	positive regulation of CD8-positive, alpha-beta T cell proliferation(GO:2000566)
0.0	0.1	GO:0048295	positive regulation of isotype switching to IgE isotypes(GO:0048295)
0.0	0.1	GO:0032911	negative regulation of transforming growth factor beta1 production(GO:0032911)
0.0	0.1	GO:0006419	alanyl-tRNA aminoacylation(GO:0006419)
0.0	0.1	GO:0006041	glucosamine metabolic process(GO:0006041)
0.0	0.1	GO:0016259	selenocysteine metabolic process(GO:0016259)
0.0	0.1	GO:0015822	ornithine transport(GO:0015822) L-ornithine transmembrane transport(GO:1903352)
0.0	0.1	GO:1904742	regulation of telomeric DNA binding(GO:1904742)
0.0	0.1	GO:0021764	amygdala development(GO:0021764)
0.0	0.2	GO:0032464	positive regulation of protein homooligomerization(GO:0032464)
0.0	0.1	GO:0017183	peptidyl-diphthamide metabolic process(GO:0017182) peptidyl-diphthamide biosynthetic process from peptidyl-histidine(GO:0017183)
0.0	0.1	GO:0060689	cell differentiation involved in salivary gland development(GO:0060689)
0.0	0.1	GO:0045636	positive regulation of melanocyte differentiation(GO:0045636)
0.0	0.2	GO:0034310	primary alcohol catabolic process(GO:0034310)
0.0	0.1	GO:0051466	positive regulation of corticotropin-releasing hormone secretion(GO:0051466)
0.0	0.1	GO:1903750	regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide(GO:1903750) negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide(GO:1903751)
0.0	0.1	GO:0002904	positive regulation of B cell apoptotic process(GO:0002904)
0.0	0.1	GO:0000957	mitochondrial RNA catabolic process(GO:0000957) regulation of mitochondrial RNA catabolic process(GO:0000960)
0.0	0.1	GO:0060448	dichotomous subdivision of terminal units involved in lung branching(GO:0060448)
0.0	0.1	GO:0045719	negative regulation of glycogen biosynthetic process(GO:0045719)
0.0	0.1	GO:0014900	regulation of muscle hyperplasia(GO:0014738) muscle hyperplasia(GO:0014900)
0.0	0.1	GO:0060528	secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development(GO:0060528)
0.0	0.2	GO:0035457	cellular response to interferon-alpha(GO:0035457)
0.0	0.1	GO:0032058	positive regulation of translational initiation in response to stress(GO:0032058)
0.0	0.3	GO:0006527	arginine catabolic process(GO:0006527)
0.0	0.1	GO:0032066	nucleolus to nucleoplasm transport(GO:0032066)
0.0	0.1	GO:0008050	female courtship behavior(GO:0008050)
0.0	0.1	GO:0051771	negative regulation of nitric-oxide synthase biosynthetic process(GO:0051771)
0.0	0.1	GO:0006059	hexitol metabolic process(GO:0006059)
0.0	0.1	GO:0010891	negative regulation of sequestering of triglyceride(GO:0010891)
0.0	0.2	GO:0019800	peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.0	0.1	GO:0010871	negative regulation of receptor biosynthetic process(GO:0010871)
0.0	0.1	GO:0033625	positive regulation of integrin activation(GO:0033625)
0.0	0.1	GO:0035790	platelet-derived growth factor receptor-alpha signaling pathway(GO:0035790)
0.0	0.1	GO:0003241	growth involved in heart morphogenesis(GO:0003241)
0.0	0.1	GO:0019626	short-chain fatty acid catabolic process(GO:0019626)
0.0	0.1	GO:0001880	Mullerian duct regression(GO:0001880)
0.0	0.0	GO:0038091	VEGF-activated platelet-derived growth factor receptor signaling pathway(GO:0038086) positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway(GO:0038091)
0.0	0.1	GO:0097374	sensory neuron axon guidance(GO:0097374)
0.0	0.2	GO:0010944	negative regulation of transcription by competitive promoter binding(GO:0010944)
0.0	0.0	GO:1901187	regulation of ephrin receptor signaling pathway(GO:1901187)
0.0	0.4	GO:0032011	ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.0	0.1	GO:0060164	regulation of timing of neuron differentiation(GO:0060164)
0.0	0.1	GO:1903753	negative regulation of p38MAPK cascade(GO:1903753)
0.0	0.1	GO:0046341	CDP-diacylglycerol metabolic process(GO:0046341)
0.0	0.1	GO:0090086	negative regulation of protein deubiquitination(GO:0090086)
0.0	0.1	GO:1990034	calcium ion export from cell(GO:1990034)
0.0	0.1	GO:0006528	asparagine metabolic process(GO:0006528)
0.0	0.1	GO:0060235	lens induction in camera-type eye(GO:0060235)
0.0	0.1	GO:0071926	cannabinoid signaling pathway(GO:0038171) endocannabinoid signaling pathway(GO:0071926)
0.0	0.3	GO:0006857	oligopeptide transport(GO:0006857)
0.0	0.2	GO:0035520	monoubiquitinated protein deubiquitination(GO:0035520)
0.0	0.1	GO:0008588	release of cytoplasmic sequestered NF-kappaB(GO:0008588)
0.0	0.1	GO:0098908	regulation of neuronal action potential(GO:0098908)
0.0	0.1	GO:0072102	glomerulus morphogenesis(GO:0072102)
0.0	0.1	GO:0010825	positive regulation of centrosome duplication(GO:0010825)
0.0	0.1	GO:2000504	positive regulation of blood vessel remodeling(GO:2000504)
0.0	0.2	GO:0023035	CD40 signaling pathway(GO:0023035)
0.0	0.1	GO:0009449	gamma-aminobutyric acid biosynthetic process(GO:0009449)
0.0	0.1	GO:0001907	killing by symbiont of host cells(GO:0001907) disruption by symbiont of host cell(GO:0044004)
0.0	0.2	GO:0006662	glycerol ether metabolic process(GO:0006662)
0.0	0.1	GO:2000437	monocyte extravasation(GO:0035696) regulation of monocyte extravasation(GO:2000437)
0.0	0.0	GO:0048850	hypophysis morphogenesis(GO:0048850)
0.0	0.1	GO:0061625	fructose catabolic process(GO:0006001) fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate(GO:0061624) glycolytic process through fructose-1-phosphate(GO:0061625)
0.0	0.0	GO:0048852	diencephalon morphogenesis(GO:0048852)
0.0	0.1	GO:0042427	serotonin biosynthetic process(GO:0042427) primary amino compound biosynthetic process(GO:1901162)
0.0	0.1	GO:0045046	peroxisomal membrane transport(GO:0015919) protein import into peroxisome membrane(GO:0045046)
0.0	0.1	GO:0071397	cellular response to cholesterol(GO:0071397)
0.0	0.1	GO:0061535	glutamate secretion, neurotransmission(GO:0061535)
0.0	0.1	GO:0010528	regulation of transposition(GO:0010528) negative regulation of transposition(GO:0010529)
0.0	0.1	GO:0060020	Bergmann glial cell differentiation(GO:0060020)
0.0	0.1	GO:0097118	neuroligin clustering involved in postsynaptic membrane assembly(GO:0097118)
0.0	0.0	GO:1903624	regulation of DNA catabolic process(GO:1903624)
0.0	0.4	GO:0003416	endochondral bone growth(GO:0003416)
0.0	0.1	GO:1903525	regulation of membrane tubulation(GO:1903525)
0.0	0.1	GO:0021699	cerebellar cortex maturation(GO:0021699)
0.0	0.0	GO:1904504	regulation of lipophagy(GO:1904502) positive regulation of lipophagy(GO:1904504)
0.0	0.1	GO:0072711	response to hydroxyurea(GO:0072710) cellular response to hydroxyurea(GO:0072711)
0.0	0.1	GO:0008228	opsonization(GO:0008228)
0.0	0.0	GO:0032439	endosome localization(GO:0032439)
0.0	0.6	GO:0019373	epoxygenase P450 pathway(GO:0019373)
0.0	0.1	GO:0090361	platelet-derived growth factor production(GO:0090360) regulation of platelet-derived growth factor production(GO:0090361)
0.0	0.1	GO:0035284	central nervous system segmentation(GO:0035283) brain segmentation(GO:0035284)
0.0	0.1	GO:0044598	polyketide metabolic process(GO:0030638) aminoglycoside antibiotic metabolic process(GO:0030647) daunorubicin metabolic process(GO:0044597) doxorubicin metabolic process(GO:0044598)
0.0	0.1	GO:0036135	Schwann cell migration(GO:0036135) regulation of Schwann cell migration(GO:1900147)
0.0	0.1	GO:1904417	regulation of xenophagy(GO:1904415) positive regulation of xenophagy(GO:1904417)
0.0	0.1	GO:0034392	negative regulation of smooth muscle cell apoptotic process(GO:0034392)
0.0	0.1	GO:0006477	protein sulfation(GO:0006477)
0.0	0.1	GO:0001778	plasma membrane repair(GO:0001778)
0.0	0.1	GO:0042732	D-xylose metabolic process(GO:0042732)
0.0	0.1	GO:0016344	meiotic chromosome movement towards spindle pole(GO:0016344)
0.0	0.1	GO:0051562	negative regulation of mitochondrial calcium ion concentration(GO:0051562)
0.0	0.1	GO:0007208	phospholipase C-activating serotonin receptor signaling pathway(GO:0007208)
0.0	0.1	GO:0006538	glutamate catabolic process(GO:0006538)
0.0	0.1	GO:0090267	positive regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090267)
0.0	0.1	GO:2000042	negative regulation of double-strand break repair via homologous recombination(GO:2000042)
0.0	0.0	GO:0021986	epithalamus development(GO:0021538) habenula development(GO:0021986)
0.0	0.0	GO:0019805	quinolinate biosynthetic process(GO:0019805)
0.0	0.0	GO:0006808	regulation of nitrogen utilization(GO:0006808)
0.0	0.1	GO:0015838	amino-acid betaine transport(GO:0015838)
0.0	0.1	GO:0022027	interkinetic nuclear migration(GO:0022027)
0.0	0.0	GO:0021590	cerebellum maturation(GO:0021590)
0.0	0.0	GO:0000965	mitochondrial RNA 3'-end processing(GO:0000965)
0.0	0.0	GO:0035791	platelet-derived growth factor receptor-beta signaling pathway(GO:0035791)
0.0	0.1	GO:0035562	negative regulation of chromatin binding(GO:0035562)
0.0	0.1	GO:0006013	mannose metabolic process(GO:0006013)
0.0	0.1	GO:0032286	central nervous system myelin maintenance(GO:0032286)
0.0	0.1	GO:2000391	regulation of neutrophil extravasation(GO:2000389) positive regulation of neutrophil extravasation(GO:2000391)
0.0	0.1	GO:0007221	positive regulation of transcription of Notch receptor target(GO:0007221)
0.0	0.0	GO:0007619	courtship behavior(GO:0007619)
0.0	0.0	GO:0006172	ADP biosynthetic process(GO:0006172)
0.0	0.0	GO:0035962	response to interleukin-13(GO:0035962) cellular response to interleukin-13(GO:0035963)
0.0	0.0	GO:0060468	prevention of polyspermy(GO:0060468)
0.0	0.0	GO:0051964	negative regulation of synapse assembly(GO:0051964)
0.0	0.0	GO:0033387	putrescine biosynthetic process from ornithine(GO:0033387)
0.0	0.1	GO:0030948	negative regulation of vascular endothelial growth factor receptor signaling pathway(GO:0030948)
0.0	0.1	GO:0019227	neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.0	0.0	GO:0045634	regulation of melanocyte differentiation(GO:0045634)
0.0	0.1	GO:0019244	lactate biosynthetic process from pyruvate(GO:0019244) lactate biosynthetic process(GO:0019249)
0.0	0.1	GO:0042448	progesterone metabolic process(GO:0042448)
0.0	0.1	GO:0002741	positive regulation of cytokine secretion involved in immune response(GO:0002741)
0.0	0.0	GO:1902809	regulation of skeletal muscle fiber differentiation(GO:1902809)
0.0	0.0	GO:0000320	re-entry into mitotic cell cycle(GO:0000320)
0.0	0.1	GO:0034058	endosomal vesicle fusion(GO:0034058)
0.0	0.0	GO:0031296	B cell costimulation(GO:0031296)
0.0	0.0	GO:0006741	NADP biosynthetic process(GO:0006741)
0.0	0.0	GO:2000297	negative regulation of synapse maturation(GO:2000297)
0.0	0.1	GO:0034115	negative regulation of heterotypic cell-cell adhesion(GO:0034115) regulation of cell-cell adhesion involved in gastrulation(GO:0070587)
0.0	0.1	GO:0071043	CUT catabolic process(GO:0071034) CUT metabolic process(GO:0071043)
0.0	0.0	GO:0050968	detection of chemical stimulus involved in sensory perception of pain(GO:0050968)
0.0	0.1	GO:0090336	positive regulation of brown fat cell differentiation(GO:0090336)
0.0	0.2	GO:0006309	apoptotic DNA fragmentation(GO:0006309)
0.0	0.0	GO:0018343	protein farnesylation(GO:0018343)
0.0	0.0	GO:0048014	Tie signaling pathway(GO:0048014)
0.0	0.1	GO:0051639	actin filament network formation(GO:0051639)
0.0	0.1	GO:0032462	regulation of protein homooligomerization(GO:0032462) negative regulation of protein homooligomerization(GO:0032463)
0.0	0.0	GO:1900748	positive regulation of vascular endothelial growth factor signaling pathway(GO:1900748)
0.0	0.0	GO:0097112	gamma-aminobutyric acid receptor clustering(GO:0097112)
0.0	0.1	GO:0051151	negative regulation of smooth muscle cell differentiation(GO:0051151)
0.0	0.0	GO:0098902	regulation of membrane depolarization during action potential(GO:0098902)
0.0	0.0	GO:0051661	maintenance of centrosome location(GO:0051661)
0.0	0.0	GO:2000370	positive regulation of clathrin-mediated endocytosis(GO:2000370)
0.0	0.1	GO:0006930	substrate-dependent cell migration, cell extension(GO:0006930)
0.0	0.1	GO:0070934	CRD-mediated mRNA stabilization(GO:0070934)
0.0	0.0	GO:0033132	negative regulation of glucokinase activity(GO:0033132) negative regulation of hexokinase activity(GO:1903300)
0.0	0.0	GO:0000429	carbon catabolite regulation of transcription from RNA polymerase II promoter(GO:0000429) carbon catabolite activation of transcription from RNA polymerase II promoter(GO:0000436)
0.0	0.0	GO:0043988	histone H3-S28 phosphorylation(GO:0043988)
0.0	0.1	GO:0046069	cGMP catabolic process(GO:0046069)
0.0	0.0	GO:0060527	prostate glandular acinus morphogenesis(GO:0060526) prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis(GO:0060527)
0.0	0.1	GO:0006207	'de novo' pyrimidine nucleobase biosynthetic process(GO:0006207) pyrimidine nucleobase biosynthetic process(GO:0019856)
0.0	0.0	GO:0042706	eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate commitment(GO:0046552)
0.0	0.0	GO:1902309	negative regulation of peptidyl-serine dephosphorylation(GO:1902309)
0.0	0.1	GO:0048563	post-embryonic organ morphogenesis(GO:0048563)
0.0	0.0	GO:0033216	ferric iron import(GO:0033216) ferric iron import into cell(GO:0097461)
0.0	0.0	GO:0006003	fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.0	0.0	GO:0002669	positive regulation of T cell anergy(GO:0002669) positive regulation of lymphocyte anergy(GO:0002913)
0.0	0.0	GO:0072093	ureteric bud invasion(GO:0072092) metanephric renal vesicle formation(GO:0072093)
0.0	0.0	GO:0002025	vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure(GO:0002025)
0.0	0.1	GO:0042270	protection from natural killer cell mediated cytotoxicity(GO:0042270)
0.0	0.0	GO:1902219	intrinsic apoptotic signaling pathway in response to osmotic stress(GO:0008627) regulation of intrinsic apoptotic signaling pathway in response to osmotic stress(GO:1902218) negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress(GO:1902219)
0.0	0.1	GO:0046051	UTP biosynthetic process(GO:0006228) UTP metabolic process(GO:0046051)
0.0	0.0	GO:0032430	positive regulation of phospholipase A2 activity(GO:0032430)
0.0	0.0	GO:0021553	olfactory nerve development(GO:0021553)
0.0	0.0	GO:0071922	establishment of sister chromatid cohesion(GO:0034085) cohesin loading(GO:0071921) regulation of cohesin loading(GO:0071922)
0.0	0.1	GO:0070189	kynurenine metabolic process(GO:0070189)
0.0	0.0	GO:0016480	negative regulation of transcription from RNA polymerase III promoter(GO:0016480)
0.0	0.0	GO:0045348	positive regulation of MHC class II biosynthetic process(GO:0045348)
0.0	0.0	GO:1901078	negative regulation of relaxation of muscle(GO:1901078)
0.0	0.0	GO:0034047	regulation of protein phosphatase type 2A activity(GO:0034047)
0.0	0.1	GO:0051764	actin crosslink formation(GO:0051764)
0.0	0.1	GO:0009068	aspartate family amino acid catabolic process(GO:0009068)
0.0	0.0	GO:1900127	positive regulation of hyaluronan biosynthetic process(GO:1900127)
0.0	0.0	GO:0061368	behavioral response to chemical pain(GO:0061366) behavioral response to formalin induced pain(GO:0061368)
0.0	0.1	GO:1990001	inhibition of cysteine-type endopeptidase activity(GO:0097340) zymogen inhibition(GO:0097341) inhibition of cysteine-type endopeptidase activity involved in apoptotic process(GO:1990001)
0.0	0.1	GO:0021540	corpus callosum morphogenesis(GO:0021540)
0.0	0.1	GO:0032876	negative regulation of DNA endoreduplication(GO:0032876)
0.0	0.1	GO:0070166	enamel mineralization(GO:0070166)
0.0	0.0	GO:0035524	proline transmembrane transport(GO:0035524)
0.0	0.0	GO:0070368	positive regulation of hepatocyte differentiation(GO:0070368)
0.0	0.1	GO:0007256	activation of JNKK activity(GO:0007256)
0.0	0.1	GO:0007202	activation of phospholipase C activity(GO:0007202)
0.0	0.1	GO:0034063	stress granule assembly(GO:0034063)
0.0	0.1	GO:0048875	chemical homeostasis within a tissue(GO:0048875)
0.0	0.1	GO:0010459	negative regulation of heart rate(GO:0010459)
0.0	0.0	GO:0090074	negative regulation of protein homodimerization activity(GO:0090074)
0.0	0.0	GO:1903416	response to glycoside(GO:1903416)
0.0	0.0	GO:2000705	regulation of dense core granule biogenesis(GO:2000705)
0.0	0.1	GO:0061032	visceral serous pericardium development(GO:0061032)
0.0	0.1	GO:0032570	response to progesterone(GO:0032570)
0.0	0.0	GO:0097167	circadian regulation of translation(GO:0097167)
0.0	0.0	GO:0010572	positive regulation of platelet activation(GO:0010572)
0.0	0.1	GO:0048703	embryonic viscerocranium morphogenesis(GO:0048703)
0.0	0.0	GO:0070213	protein auto-ADP-ribosylation(GO:0070213)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	0.5	GO:0097487	multivesicular body, internal vesicle(GO:0097487)
0.1	0.2	GO:0097025	MPP7-DLG1-LIN7 complex(GO:0097025)
0.1	0.2	GO:0038037	G-protein coupled receptor dimeric complex(GO:0038037) G-protein coupled receptor complex(GO:0097648)
0.0	0.2	GO:0045098	type III intermediate filament(GO:0045098)
0.0	0.1	GO:0042825	TAP complex(GO:0042825)
0.0	0.1	GO:0097441	basilar dendrite(GO:0097441)
0.0	0.1	GO:0044316	cone cell pedicle(GO:0044316)
0.0	0.1	GO:1990907	beta-catenin-TCF complex(GO:1990907)
0.0	0.1	GO:0034666	integrin alpha2-beta1 complex(GO:0034666)
0.0	0.1	GO:1990851	Wnt-Frizzled-LRP5/6 complex(GO:1990851)
0.0	0.2	GO:0008024	cyclin/CDK positive transcription elongation factor complex(GO:0008024)
0.0	0.3	GO:0071564	npBAF complex(GO:0071564)
0.0	0.1	GO:1990111	spermatoproteasome complex(GO:1990111)
0.0	0.1	GO:0016461	unconventional myosin complex(GO:0016461)
0.0	0.1	GO:0030981	cortical microtubule cytoskeleton(GO:0030981)
0.0	0.3	GO:0097440	apical dendrite(GO:0097440)
0.0	0.1	GO:0005785	signal recognition particle receptor complex(GO:0005785)
0.0	0.1	GO:0035985	senescence-associated heterochromatin focus(GO:0035985)
0.0	0.1	GO:0043625	delta DNA polymerase complex(GO:0043625)
0.0	0.1	GO:0072534	perineuronal net(GO:0072534)
0.0	0.1	GO:0031315	extrinsic component of mitochondrial outer membrane(GO:0031315)
0.0	0.1	GO:0014731	spectrin-associated cytoskeleton(GO:0014731)
0.0	0.2	GO:0098533	ATPase dependent transmembrane transport complex(GO:0098533)
0.0	0.1	GO:0031313	extrinsic component of endosome membrane(GO:0031313)
0.0	0.1	GO:0016342	catenin complex(GO:0016342)
0.0	0.1	GO:0030689	Noc complex(GO:0030689)
0.0	0.1	GO:0034457	Mpp10 complex(GO:0034457)
0.0	0.1	GO:0032777	Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.0	0.1	GO:0000275	mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275) proton-transporting ATP synthase complex, catalytic core F(1)(GO:0045261)
0.0	0.2	GO:0000940	condensed chromosome outer kinetochore(GO:0000940)
0.0	0.0	GO:0032127	dense core granule membrane(GO:0032127)
0.0	0.1	GO:0005915	zonula adherens(GO:0005915)
0.0	0.1	GO:0097433	dense body(GO:0097433)
0.0	0.2	GO:0001891	phagocytic cup(GO:0001891)
0.0	0.1	GO:0033116	endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116)
0.0	0.1	GO:0072557	IPAF inflammasome complex(GO:0072557)
0.0	0.0	GO:0005971	ribonucleoside-diphosphate reductase complex(GO:0005971)
0.0	0.2	GO:0042101	T cell receptor complex(GO:0042101)
0.0	0.1	GO:0045180	basal cortex(GO:0045180)
0.0	0.1	GO:0034715	pICln-Sm protein complex(GO:0034715)
0.0	0.0	GO:0097524	sperm plasma membrane(GO:0097524)
0.0	0.0	GO:0060053	neurofilament cytoskeleton(GO:0060053)
0.0	0.1	GO:0001520	outer dense fiber(GO:0001520)
0.0	0.1	GO:0031235	intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.0	0.1	GO:0031464	Cul4A-RING E3 ubiquitin ligase complex(GO:0031464)
0.0	0.1	GO:0032580	Golgi cisterna membrane(GO:0032580)
0.0	0.1	GO:0030867	rough endoplasmic reticulum membrane(GO:0030867)
0.0	0.0	GO:0014701	junctional sarcoplasmic reticulum membrane(GO:0014701)
0.0	0.1	GO:0070937	CRD-mediated mRNA stability complex(GO:0070937)
0.0	0.0	GO:0043511	inhibin complex(GO:0043511)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	0.5	GO:0005006	epidermal growth factor-activated receptor activity(GO:0005006)
0.1	0.2	GO:0050508	glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity(GO:0050508)
0.1	0.2	GO:0097109	neuroligin family protein binding(GO:0097109)
0.1	0.2	GO:0008321	Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.1	0.2	GO:0070538	oleic acid binding(GO:0070538)
0.1	0.2	GO:0004839	ubiquitin activating enzyme activity(GO:0004839)
0.1	0.2	GO:0035529	NADH pyrophosphatase activity(GO:0035529)
0.1	0.2	GO:0004965	G-protein coupled GABA receptor activity(GO:0004965)
0.0	0.1	GO:0050692	DBD domain binding(GO:0050692)
0.0	0.1	GO:0045504	dynein heavy chain binding(GO:0045504)
0.0	0.2	GO:0016212	kynurenine-oxoglutarate transaminase activity(GO:0016212) kynurenine aminotransferase activity(GO:0036137)
0.0	0.3	GO:0004768	stearoyl-CoA 9-desaturase activity(GO:0004768)
0.0	0.2	GO:0016899	oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor(GO:0016899)
0.0	0.3	GO:0015198	oligopeptide transporter activity(GO:0015198)
0.0	0.1	GO:0004924	oncostatin-M receptor activity(GO:0004924)
0.0	0.1	GO:0060230	lipoprotein lipase activator activity(GO:0060230)
0.0	0.1	GO:0046978	TAP1 binding(GO:0046978) TAP2 binding(GO:0046979)
0.0	0.1	GO:0004687	myosin light chain kinase activity(GO:0004687)
0.0	0.2	GO:0047023	androsterone dehydrogenase activity(GO:0047023)
0.0	0.1	GO:0016647	oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor(GO:0016647)
0.0	0.1	GO:0050816	phosphothreonine binding(GO:0050816)
0.0	0.1	GO:0004046	aminoacylase activity(GO:0004046)
0.0	0.1	GO:0042392	sphingosine-1-phosphate phosphatase activity(GO:0042392)
0.0	0.1	GO:1990050	phosphatidic acid transporter activity(GO:1990050)
0.0	0.1	GO:0005128	erythropoietin receptor binding(GO:0005128)
0.0	0.2	GO:0030284	estrogen receptor activity(GO:0030284)
0.0	0.1	GO:0030160	GKAP/Homer scaffold activity(GO:0030160)
0.0	0.2	GO:0004769	steroid delta-isomerase activity(GO:0004769)
0.0	0.1	GO:0003945	N-acetyllactosamine synthase activity(GO:0003945)
0.0	0.1	GO:0050833	pyruvate transmembrane transporter activity(GO:0050833)
0.0	0.1	GO:0043125	ErbB-3 class receptor binding(GO:0043125)
0.0	0.1	GO:0004813	alanine-tRNA ligase activity(GO:0004813)
0.0	0.2	GO:0005078	MAP-kinase scaffold activity(GO:0005078)
0.0	0.1	GO:0035276	ethanol binding(GO:0035276)
0.0	0.1	GO:0022833	mechanically-gated ion channel activity(GO:0008381) mechanically gated channel activity(GO:0022833)
0.0	0.1	GO:0051880	G-quadruplex DNA binding(GO:0051880)
0.0	0.1	GO:0004887	thyroid hormone receptor activity(GO:0004887)
0.0	0.1	GO:0004634	phosphopyruvate hydratase activity(GO:0004634)
0.0	0.1	GO:0003986	acetyl-CoA hydrolase activity(GO:0003986)
0.0	0.1	GO:0004396	glucokinase activity(GO:0004340) hexokinase activity(GO:0004396)
0.0	0.1	GO:0030984	kininogen binding(GO:0030984)
0.0	0.1	GO:0000064	L-ornithine transmembrane transporter activity(GO:0000064)
0.0	0.1	GO:0004505	phenylalanine 4-monooxygenase activity(GO:0004505)
0.0	0.2	GO:0004661	protein geranylgeranyltransferase activity(GO:0004661)
0.0	0.1	GO:0048101	calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101)
0.0	0.1	GO:0004605	phosphatidate cytidylyltransferase activity(GO:0004605)
0.0	0.2	GO:0000900	translation repressor activity, nucleic acid binding(GO:0000900)
0.0	0.2	GO:0050308	sugar-phosphatase activity(GO:0050308)
0.0	0.4	GO:0042975	peroxisome proliferator activated receptor binding(GO:0042975)
0.0	0.1	GO:0000182	rDNA binding(GO:0000182)
0.0	0.1	GO:0004994	somatostatin receptor activity(GO:0004994)
0.0	0.3	GO:0045295	gamma-catenin binding(GO:0045295)
0.0	0.3	GO:0031690	adrenergic receptor binding(GO:0031690)
0.0	0.1	GO:0003708	retinoic acid receptor activity(GO:0003708)
0.0	0.2	GO:0016813	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.0	0.0	GO:0004939	beta-adrenergic receptor activity(GO:0004939)
0.0	0.1	GO:0071933	Arp2/3 complex binding(GO:0071933)
0.0	0.1	GO:0004566	beta-glucuronidase activity(GO:0004566)
0.0	0.1	GO:0050700	CARD domain binding(GO:0050700)
0.0	0.1	GO:0043723	N-cyclopropylmelamine deaminase activity(GO:0034547) N-cyclopropylammeline deaminase activity(GO:0034548) N-cyclopropylammelide alkylamino hydrolase activity(GO:0034549) 2,5-diamino-6-ribitylamino-4(3H)-pyrimidinone 5'-phosphate deaminase activity(GO:0043723) tRNA-specific adenosine-37 deaminase activity(GO:0043829) archaeal-specific GTP cyclohydrolase activity(GO:0044682) tRNA-specific adenosine-34 deaminase activity(GO:0052717)
0.0	0.1	GO:0032190	acrosin binding(GO:0032190)
0.0	0.1	GO:0005280	hydrogen:amino acid symporter activity(GO:0005280)
0.0	0.5	GO:0001205	transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.0	0.0	GO:0008251	tRNA-specific adenosine deaminase activity(GO:0008251)
0.0	0.1	GO:0042296	ISG15 transferase activity(GO:0042296)
0.0	0.1	GO:0070061	fructose binding(GO:0070061)
0.0	0.0	GO:0070699	type II activin receptor binding(GO:0070699)
0.0	0.1	GO:0016174	NAD(P)H oxidase activity(GO:0016174)
0.0	0.1	GO:0005047	signal recognition particle binding(GO:0005047)
0.0	0.0	GO:0008384	IkappaB kinase activity(GO:0008384)
0.0	0.0	GO:1990239	steroid hormone binding(GO:1990239)
0.0	0.0	GO:0016215	acyl-CoA desaturase activity(GO:0016215)
0.0	0.1	GO:0055056	D-glucose transmembrane transporter activity(GO:0055056)
0.0	0.1	GO:0046790	virion binding(GO:0046790)
0.0	0.3	GO:0005086	ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.0	0.1	GO:0016679	oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679)
0.0	0.1	GO:0005536	glucose binding(GO:0005536)
0.0	0.1	GO:1990715	mRNA CDS binding(GO:1990715)
0.0	0.1	GO:0008432	JUN kinase binding(GO:0008432)
0.0	0.1	GO:0004758	serine C-palmitoyltransferase activity(GO:0004758)
0.0	0.1	GO:0005041	low-density lipoprotein receptor activity(GO:0005041)
0.0	0.0	GO:0030911	TPR domain binding(GO:0030911)
0.0	0.1	GO:0005290	L-histidine transmembrane transporter activity(GO:0005290)
0.0	0.1	GO:0005021	vascular endothelial growth factor-activated receptor activity(GO:0005021)
0.0	0.1	GO:0008093	cytoskeletal adaptor activity(GO:0008093)
0.0	0.1	GO:0003847	1-alkyl-2-acetylglycerophosphocholine esterase activity(GO:0003847)
0.0	0.1	GO:0008195	phosphatidate phosphatase activity(GO:0008195)
0.0	0.0	GO:0097603	temperature-gated ion channel activity(GO:0097603)
0.0	0.1	GO:0042809	vitamin D receptor binding(GO:0042809)
0.0	0.1	GO:0034875	oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor(GO:0033695) caffeine oxidase activity(GO:0034875)
0.0	0.0	GO:0017098	sulfonylurea receptor binding(GO:0017098)
0.0	0.1	GO:0034450	ubiquitin-ubiquitin ligase activity(GO:0034450)
0.0	0.1	GO:0051434	BH3 domain binding(GO:0051434)
0.0	0.0	GO:0019770	IgG receptor activity(GO:0019770)
0.0	0.0	GO:0061731	ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.0	0.1	GO:0048019	receptor antagonist activity(GO:0048019)
0.0	0.1	GO:0008331	high voltage-gated calcium channel activity(GO:0008331)
0.0	0.2	GO:0016671	oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor(GO:0016671)
0.0	0.0	GO:0004514	nicotinate-nucleotide diphosphorylase (carboxylating) activity(GO:0004514)
0.0	0.1	GO:0070728	leucine binding(GO:0070728)
0.0	0.0	GO:0097108	hedgehog family protein binding(GO:0097108)
0.0	0.0	GO:0047391	alkylglycerophosphoethanolamine phosphodiesterase activity(GO:0047391)
0.0	0.0	GO:0050510	N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity(GO:0050510)
0.0	0.1	GO:0043237	laminin-1 binding(GO:0043237)
0.0	0.0	GO:0005345	purine nucleobase transmembrane transporter activity(GO:0005345) pyrimidine nucleobase transmembrane transporter activity(GO:0005350) nucleobase transmembrane transporter activity(GO:0015205)
0.0	0.1	GO:0032552	deoxyribonucleotide binding(GO:0032552)
0.0	0.1	GO:0016724	ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.0	0.1	GO:0017127	cholesterol transporter activity(GO:0017127)
0.0	0.1	GO:0004439	phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity(GO:0004439)
0.0	0.0	GO:0052851	cupric reductase activity(GO:0008823) ferric-chelate reductase (NADPH) activity(GO:0052851)
0.0	0.0	GO:0004920	interleukin-10 receptor activity(GO:0004920)
0.0	0.0	GO:0030942	endoplasmic reticulum signal peptide binding(GO:0030942)
0.0	0.1	GO:0047372	acylglycerol lipase activity(GO:0047372)
0.0	0.0	GO:1904680	peptide transmembrane transporter activity(GO:1904680)
0.0	0.1	GO:0030292	protein tyrosine kinase inhibitor activity(GO:0030292)
0.0	0.0	GO:0008532	N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity(GO:0008532)
0.0	0.0	GO:0071614	linoleic acid epoxygenase activity(GO:0071614)
0.0	0.1	GO:0005172	vascular endothelial growth factor receptor binding(GO:0005172)
0.0	0.1	GO:0032184	SUMO polymer binding(GO:0032184)
0.0	0.2	GO:0019200	carbohydrate kinase activity(GO:0019200)
0.0	0.1	GO:0004806	triglyceride lipase activity(GO:0004806)
0.0	0.1	GO:0018636	phenanthrene 9,10-monooxygenase activity(GO:0018636)
0.0	0.1	GO:0004457	lactate dehydrogenase activity(GO:0004457)
0.0	0.1	GO:0005004	GPI-linked ephrin receptor activity(GO:0005004)
0.0	0.1	GO:0060229	lipase activator activity(GO:0060229)
0.0	0.0	GO:0016530	metallochaperone activity(GO:0016530) copper chaperone activity(GO:0016531)
0.0	0.1	GO:0071253	connexin binding(GO:0071253)
0.0	0.1	GO:0016290	palmitoyl-CoA hydrolase activity(GO:0016290)
0.0	0.1	GO:0030371	translation repressor activity(GO:0030371)
0.0	0.1	GO:0016812	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides(GO:0016812)
0.0	0.0	GO:0008607	phosphorylase kinase regulator activity(GO:0008607)
0.0	0.0	GO:0097016	L27 domain binding(GO:0097016)

Gene overrepresentation in curated gene sets: canonical pathways category:

Total log-likelihood	Term	Description
0.7	PID ERBB NETWORK PATHWAY	ErbB receptor signaling network
0.3	SA PROGRAMMED CELL DEATH	Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.6	PID FOXM1 PATHWAY	FOXM1 transcription factor network
0.1	ST STAT3 PATHWAY	STAT3 Pathway
0.0	SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES	Genes related to the insulin receptor pathway
0.0	PID INTEGRIN3 PATHWAY	Beta3 integrin cell surface interactions
0.0	ST WNT CA2 CYCLIC GMP PATHWAY	Wnt/Ca2+/cyclic GMP signaling.
0.1	PID VEGF VEGFR PATHWAY	VEGF and VEGFR signaling network
0.0	PID EPHA2 FWD PATHWAY	EPHA2 forward signaling
0.0	PID NFKAPPAB ATYPICAL PATHWAY	Atypical NF-kappaB pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Total log-likelihood	Term	Description
0.1	REACTOME XENOBIOTICS	Genes involved in Xenobiotics
0.6	REACTOME SHC1 EVENTS IN EGFR SIGNALING	Genes involved in SHC1 events in EGFR signaling
0.4	REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY	Genes involved in TRAF3-dependent IRF activation pathway
0.2	REACTOME SHC1 EVENTS IN ERBB4 SIGNALING	Genes involved in SHC1 events in ERBB4 signaling
0.4	REACTOME GROWTH HORMONE RECEPTOR SIGNALING	Genes involved in Growth hormone receptor signaling
0.3	REACTOME ACTIVATION OF BH3 ONLY PROTEINS	Genes involved in Activation of BH3-only proteins
0.2	REACTOME ALPHA LINOLENIC ACID ALA METABOLISM	Genes involved in alpha-linolenic acid (ALA) metabolism
0.1	REACTOME PROLONGED ERK ACTIVATION EVENTS	Genes involved in Prolonged ERK activation events
0.2	REACTOME GAP JUNCTION DEGRADATION	Genes involved in Gap junction degradation
0.5	REACTOME REGULATION OF BETA CELL DEVELOPMENT	Genes involved in Regulation of beta-cell development
0.2	REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC	Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.1	REACTOME IL 7 SIGNALING	Genes involved in Interleukin-7 signaling
0.2	REACTOME ENDOGENOUS STEROLS	Genes involved in Endogenous sterols
0.1	REACTOME RNA POL I TRANSCRIPTION	Genes involved in RNA Polymerase I Transcription
0.1	REACTOME MTORC1 MEDIATED SIGNALLING	Genes involved in mTORC1-mediated signalling
0.2	REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS	Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.2	REACTOME PYRIMIDINE CATABOLISM	Genes involved in Pyrimidine catabolism
0.1	REACTOME VEGF LIGAND RECEPTOR INTERACTIONS	Genes involved in VEGF ligand-receptor interactions
0.3	REACTOME GLUCONEOGENESIS	Genes involved in Gluconeogenesis
0.1	REACTOME SIGNALLING TO P38 VIA RIT AND RIN	Genes involved in Signalling to p38 via RIT and RIN
0.1	REACTOME REMOVAL OF THE FLAP INTERMEDIATE FROM THE C STRAND	Genes involved in Removal of the Flap Intermediate from the C-strand
0.4	REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION	Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.1	REACTOME RAP1 SIGNALLING	Genes involved in Rap1 signalling
0.2	REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES	Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.0	REACTOME REGULATION OF INSULIN SECRETION	Genes involved in Regulation of Insulin Secretion
0.3	REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS	Genes involved in Sphingolipid de novo biosynthesis
0.1	REACTOME DEADENYLATION OF MRNA	Genes involved in Deadenylation of mRNA

Results for Prdm1

Z-value: 1.86

Motif logo

Transcription factors associated with Prdm1

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

Activity of the Prdm1 motif across conditions

Conditions sorted by the z-value of the Prdm1 motif activity

Top target CREs of the motif:

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of Prdm1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: