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ENCSR904DTN: DNase-seq of mouse liver in constant darkness

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Results for Prrx1_Isx_Prrxl1

Z-value: 0.77

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Transcription factors associated with Prrx1_Isx_Prrxl1

Gene Symbol	Gene ID	Gene Info
Prrx1 Ensembl NCBI MGI UniProt	ENSMUSG00000026586.10	paired related homeobox 1
Isx Ensembl NCBI MGI UniProt	ENSMUSG00000031621.3	intestine specific homeobox
Prrxl1 Ensembl NCBI MGI UniProt	ENSMUSG00000041730.7	paired related homeobox protein-like 1

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
chr8_74930880_74931043	Isx	57421	0.106624	0.74	9.3e-02	Click!
chr1_163338521_163338892	Prrx1	24996	0.155250	0.65	1.6e-01	Click!
chr1_163339232_163339434	Prrx1	25623	0.154031	0.59	2.2e-01	Click!
chr1_163314475_163314642	Prrx1	848	0.594097	0.56	2.5e-01	Click!
chr1_163339006_163339167	Prrx1	25376	0.154513	0.38	4.6e-01	Click!
chr1_163314220_163314397	Prrx1	598	0.725915	0.16	7.6e-01	Click!

Activity of the Prrx1_Isx_Prrxl1 motif across conditions

Conditions sorted by the z-value of the Prrx1_Isx_Prrxl1 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr9_74672657_74672818	1.21	Gm27233	predicted gene 27233	36525	0.18
chr17_79018863_79019084	0.92	Prkd3	protein kinase D3	1804	0.3
chr9_74885383_74885534	0.85	Onecut1	one cut domain, family member 1	18974	0.14
chr11_16798476_16798627	0.72	Egfros	epidermal growth factor receptor, opposite strand	32151	0.16
chr3_76637152_76637321	0.71	Fstl5	follistatin-like 5	43686	0.19
chr9_74881714_74881880	0.68	Onecut1	one cut domain, family member 1	15313	0.15
chr5_86919547_86919811	0.64	Gm25211	predicted gene, 25211	3357	0.13
chr10_124590350_124590536	0.60	4930503E24Rik	RIKEN cDNA 4930503E24 gene	67005	0.14
chr10_87936931_87937082	0.60	Tyms-ps	thymidylate synthase, pseudogene	29841	0.15
chr15_58983651_58983950	0.60	4930544F09Rik	RIKEN cDNA 4930544F09 gene	336	0.87
chr16_43169836_43170008	0.58	Gm15712	predicted gene 15712	14651	0.21
chr1_100298746_100298897	0.55	Gm29667	predicted gene 29667	16030	0.18
chr5_33465811_33466048	0.53	Gm43851	predicted gene 43851	28465	0.15
chr11_16888258_16888409	0.52	Egfr	epidermal growth factor receptor	10183	0.2
chr11_16843001_16843162	0.51	Egfros	epidermal growth factor receptor, opposite strand	12379	0.2
chr12_51274477_51274668	0.51	Rps11-ps4	ribosomal protein S11, pseudogene 4	22915	0.22
chr17_81174915_81175073	0.50	Gm50042	predicted gene, 50042	71744	0.11
chr1_124069161_124069328	0.50	Dpp10	dipeptidylpeptidase 10	23685	0.27
chr16_4384061_4384228	0.50	Adcy9	adenylate cyclase 9	35443	0.15
chr13_115653702_115653853	0.49	Gm47892	predicted gene, 47892	65722	0.13
chr6_55171107_55171477	0.48	Inmt	indolethylamine N-methyltransferase	3722	0.2
chr10_87868820_87868971	0.48	Igf1os	insulin-like growth factor 1, opposite strand	5514	0.22
chr8_38604147_38604298	0.47	Gm40493	predicted gene, 40493	55541	0.14
chr13_24360335_24360523	0.46	Gm11342	predicted gene 11342	15521	0.12
chr11_16883025_16883203	0.46	Egfr	epidermal growth factor receptor	4964	0.23
chr15_3721208_3721477	0.45	Gm4823	predicted gene 4823	25533	0.23
chr13_28877494_28877645	0.44	2610307P16Rik	RIKEN cDNA 2610307P16 gene	5887	0.2
chr5_99976807_99976958	0.44	Hnrnpd	heterogeneous nuclear ribonucleoprotein D	331	0.73
chr4_138200371_138200549	0.43	Eif4g3	eukaryotic translation initiation factor 4 gamma, 3	1129	0.38
chr11_16761103_16761540	0.43	Egfr	epidermal growth factor receptor	9091	0.2
chr2_64059065_64059258	0.42	Fign	fidgetin	38827	0.23
chr10_4617695_4617851	0.42	Esr1	estrogen receptor 1 (alpha)	5752	0.25
chr16_43234125_43234650	0.42	Zbtb20	zinc finger and BTB domain containing 20	1493	0.45
chr19_37507552_37507703	0.41	Exoc6	exocyst complex component 6	13252	0.16
chr8_76152735_76152886	0.41	Gm45742	predicted gene 45742	35783	0.19
chr1_67150788_67150939	0.40	Cps1	carbamoyl-phosphate synthetase 1	27837	0.2
chr5_96970232_96970383	0.40	Gm9484	predicted gene 9484	27057	0.09
chr4_90082681_90082858	0.40	Gm12629	predicted gene 12629	102758	0.08
chr1_140421414_140421565	0.39	Kcnt2	potassium channel, subfamily T, member 2	21447	0.27
chr18_53860444_53860644	0.39	Csnk1g3	casein kinase 1, gamma 3	1578	0.52
chr11_80103009_80103182	0.39	Atad5	ATPase family, AAA domain containing 5	92	0.96
chr6_100267052_100267222	0.38	Gm44044	predicted gene, 44044	6561	0.17
chr3_133759501_133760150	0.38	Gm6135	prediticted gene 6135	31679	0.18
chr1_9985468_9985649	0.37	Ppp1r42	protein phosphatase 1, regulatory subunit 42	134	0.92
chr19_40153747_40153898	0.37	Cyp2c70	cytochrome P450, family 2, subfamily c, polypeptide 70	33464	0.13
chrX_61144273_61144442	0.37	Gm24396	predicted gene, 24396	1005	0.5
chr10_19452656_19452840	0.36	Gm33104	predicted gene, 33104	33967	0.17
chr5_125526040_125526191	0.36	Tmem132b	transmembrane protein 132B	5659	0.17
chr1_162891903_162892071	0.36	Fmo2	flavin containing monooxygenase 2	5472	0.19
chr19_27663441_27663619	0.34	Gm24782	predicted gene, 24782	40477	0.2
chr11_16885540_16885691	0.34	Egfr	epidermal growth factor receptor	7465	0.21
chr9_31589555_31589723	0.34	Gm18226	predicted gene, 18226	21393	0.16
chr13_44437957_44438156	0.34	1700029N11Rik	RIKEN cDNA 1700029N11 gene	1656	0.27
chr16_26702287_26702472	0.34	Il1rap	interleukin 1 receptor accessory protein	20055	0.24
chr15_38049613_38049764	0.33	Gm22353	predicted gene, 22353	8597	0.16
chr15_3475054_3475205	0.33	Ghr	growth hormone receptor	3485	0.35
chr3_142458835_142459002	0.33	Gbp5	guanylate binding protein 5	35060	0.15
chr6_108667181_108667428	0.32	Bhlhe40	basic helix-loop-helix family, member e40	4258	0.19
chr3_18137155_18137306	0.32	Gm23686	predicted gene, 23686	40395	0.15
chr2_84996201_84996436	0.32	Prg3	proteoglycan 3	8103	0.12
chr1_140415315_140415670	0.32	Kcnt2	potassium channel, subfamily T, member 2	27444	0.25
chr6_71999696_71999905	0.32	Gm26628	predicted gene, 26628	36025	0.1
chr5_92607049_92607221	0.32	Stbd1	starch binding domain 1	4067	0.19
chr4_118002076_118002227	0.31	9530034E10Rik	RIKEN cDNA 9530034E10 gene	27115	0.13
chr2_77543027_77543190	0.31	Zfp385b	zinc finger protein 385B	18872	0.25
chr3_95879412_95879563	0.31	Ciart	circadian associated repressor of transcription	1759	0.16
chr6_90434918_90435091	0.31	Cfap100	cilia and flagella associated protein 100	6207	0.12
chr15_38105734_38106027	0.31	Gm49312	predicted gene, 49312	26778	0.13
chr2_58773576_58773851	0.30	Upp2	uridine phosphorylase 2	8388	0.21
chrX_109145684_109145835	0.30	Gm14869	predicted gene 14869	24075	0.17
chr11_16854059_16854210	0.30	Egfros	epidermal growth factor receptor, opposite strand	23432	0.17
chr10_69208679_69208830	0.30	Rhobtb1	Rho-related BTB domain containing 1	202	0.94
chr2_134708873_134709037	0.30	Gm14037	predicted gene 14037	22152	0.2
chr2_121507198_121507349	0.30	Wdr76	WD repeat domain 76	490	0.46
chr3_18246603_18246795	0.30	Cyp7b1	cytochrome P450, family 7, subfamily b, polypeptide 1	3361	0.3
chr19_39282868_39283045	0.30	Cyp2c29	cytochrome P450, family 2, subfamily c, polypeptide 29	4118	0.26
chr12_75483854_75484042	0.29	Gm47690	predicted gene, 47690	24797	0.19
chr4_122977007_122977265	0.29	4933421A08Rik	RIKEN cDNA 4933421A08 gene	15827	0.12
chr10_68125559_68125710	0.29	Arid5b	AT rich interactive domain 5B (MRF1-like)	10992	0.25
chr18_36641373_36641566	0.29	Ankhd1	ankyrin repeat and KH domain containing 1	96	0.93
chr19_29120309_29120493	0.29	Mir101b	microRNA 101b	14878	0.12
chr4_99068687_99068838	0.29	Dock7	dedicator of cytokinesis 7	1651	0.35
chr5_135036438_135036589	0.29	Stx1a	syntaxin 1A (brain)	998	0.3
chr3_98670706_98671055	0.29	Gm12399	predicted gene 12399	7451	0.14
chr4_49691674_49691844	0.28	Ppp3r2	protein phosphatase 3, regulatory subunit B, alpha isoform (calcineurin B, type II)	9735	0.18
chr6_128035036_128035224	0.28	Tspan9	tetraspanin 9	125	0.96
chr8_80983213_80983373	0.28	Gm9725	predicted gene 9725	30283	0.13
chr14_17729212_17729405	0.28	Gm48320	predicted gene, 48320	41814	0.19
chr10_87040962_87041138	0.28	1700113H08Rik	RIKEN cDNA 1700113H08 gene	16995	0.16
chr1_60098880_60099160	0.28	Wdr12	WD repeat domain 12	375	0.68
chr12_99371949_99372100	0.28	Gm47138	predicted gene, 47138	2111	0.22
chr14_101841283_101841436	0.28	Lmo7	LIM domain only 7	540	0.85
chr5_81427449_81427610	0.28	Gm43084	predicted gene 43084	108197	0.07
chr9_106245058_106245282	0.27	Alas1	aminolevulinic acid synthase 1	1536	0.23
chr17_40896986_40897147	0.27	9130008F23Rik	RIKEN cDNA 9130008F23 gene	16507	0.11
chr9_122848915_122849207	0.27	Gm47140	predicted gene, 47140	643	0.55
chr11_95462552_95462764	0.27	Gm11522	predicted gene 11522	63	0.97
chr1_67222842_67222998	0.27	Gm15668	predicted gene 15668	26280	0.19
chr10_53989527_53989678	0.27	Man1a	mannosidase 1, alpha	12487	0.24
chr10_117123042_117123236	0.27	Frs2	fibroblast growth factor receptor substrate 2	7707	0.15
chr12_80323831_80324032	0.26	Dcaf5	DDB1 and CUL4 associated factor 5	52761	0.08
chrX_51399106_51399311	0.26	Gm14621	predicted gene 14621	159676	0.03
chr16_52417351_52417533	0.26	Alcam	activated leukocyte cell adhesion molecule	35023	0.23
chr3_60099135_60099299	0.26	Sucnr1	succinate receptor 1	17315	0.18
chr12_57537784_57538085	0.26	Foxa1	forkhead box A1	8187	0.15
chr3_145775927_145776137	0.26	Ddah1	dimethylarginine dimethylaminohydrolase 1	15284	0.2
chr16_77405236_77405411	0.26	Gm21816	predicted gene, 21816	4476	0.13
chr18_12696242_12696420	0.26	Ttc39c	tetratricopeptide repeat domain 39C	6603	0.15
chr5_30185873_30186127	0.26	Hadhb	hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta	5768	0.13
chr8_105095555_105095947	0.26	Ces3b	carboxylesterase 3B	7132	0.11
chr3_133725023_133725174	0.26	Gm40153	predicted gene, 40153	61707	0.1
chr7_73542824_73542975	0.26	Chd2	chromodomain helicase DNA binding protein 2	1069	0.35
chr1_45922514_45922876	0.26	Slc40a1	solute carrier family 40 (iron-regulated transporter), member 1	614	0.65
chr1_155035905_155036069	0.25	Gm29441	predicted gene 29441	4248	0.21
chr13_69640079_69640317	0.25	Nsun2	NOL1/NOP2/Sun domain family member 2	9458	0.1
chr11_16814706_16815122	0.25	Egfros	epidermal growth factor receptor, opposite strand	15788	0.21
chr4_129325663_129325914	0.25	Rbbp4	retinoblastoma binding protein 4, chromatin remodeling factor	8856	0.11
chr2_73628966_73629117	0.25	Chn1	chimerin 1	3301	0.21
chr1_185269383_185269539	0.25	Rab3gap2	RAB3 GTPase activating protein subunit 2	5619	0.11
chrX_49489499_49489695	0.25	Arhgap36	Rho GTPase activating protein 36	3922	0.27
chr2_127608341_127608498	0.25	Mrps5	mitochondrial ribosomal protein S5	8386	0.13
chr8_114140204_114140427	0.25	Nudt7	nudix (nucleoside diphosphate linked moiety X)-type motif 7	6673	0.29
chr10_20220217_20220400	0.25	Map7	microtubule-associated protein 7	9487	0.14
chr9_106264996_106265377	0.25	Poc1a	POC1 centriolar protein A	15875	0.1
chr10_93188131_93188368	0.25	Cdk17	cyclin-dependent kinase 17	6639	0.21
chr1_160968204_160968356	0.24	Serpinc1	serine (or cysteine) peptidase inhibitor, clade C (antithrombin), member 1	10305	0.07
chr4_108099165_108099370	0.24	Podn	podocan	2822	0.2
chr2_134654955_134655162	0.24	Tmx4	thioredoxin-related transmembrane protein 4	10913	0.25
chr6_91583609_91583760	0.24	Gm45215	predicted gene 45215	11074	0.14
chr12_54960526_54960699	0.24	Gm27014	predicted gene, 27014	2452	0.2
chr3_75530671_75531016	0.24	Pdcd10	programmed cell death 10	9273	0.2
chr18_7657901_7658087	0.24	Mpp7	membrane protein, palmitoylated 7 (MAGUK p55 subfamily member 7)	31128	0.17
chr2_18435403_18435565	0.24	Dnajc1	DnaJ heat shock protein family (Hsp40) member C1	42654	0.16
chr4_108060521_108060686	0.24	Scp2	sterol carrier protein 2, liver	10760	0.13
chr4_129326695_129326846	0.24	Rbbp4	retinoblastoma binding protein 4, chromatin remodeling factor	7874	0.12
chr18_75384388_75384763	0.24	Smad7	SMAD family member 7	9661	0.21
chr18_75498893_75499229	0.24	Gm10532	predicted gene 10532	15584	0.25
chr15_59002495_59002896	0.24	4930544F09Rik	RIKEN cDNA 4930544F09 gene	18559	0.16
chr1_21250942_21251436	0.24	Gsta3	glutathione S-transferase, alpha 3	2332	0.18
chr14_34332268_34332419	0.24	Glud1	glutamate dehydrogenase 1	144	0.92
chr4_40698726_40698877	0.23	Aptx	aprataxin	3915	0.15
chr7_71419354_71419520	0.23	Gm29328	predicted gene 29328	49104	0.14
chr16_45962997_45963191	0.23	Phldb2	pleckstrin homology like domain, family B, member 2	9496	0.16
chr4_148615928_148616079	0.23	Tardbp	TAR DNA binding protein	135	0.93
chr5_107123329_107123511	0.23	Tgfbr3	transforming growth factor, beta receptor III	9503	0.17
chr10_125785978_125786129	0.23	Lrig3	leucine-rich repeats and immunoglobulin-like domains 3	180115	0.03
chr13_112500544_112500748	0.23	Il6st	interleukin 6 signal transducer	25600	0.14
chr17_80022007_80022158	0.23	Gm22215	predicted gene, 22215	11432	0.14
chr9_23436438_23436789	0.23	Bmper	BMP-binding endothelial regulator	62681	0.16
chr8_109981175_109981347	0.23	Gm45795	predicted gene 45795	6909	0.13
chr13_20406351_20406565	0.23	Elmo1	engulfment and cell motility 1	66268	0.1
chr5_130227356_130227532	0.23	Gm42467	predicted gene 42467	1228	0.28
chr2_67898259_67898744	0.22	Gm37964	predicted gene, 37964	95	0.98
chr15_3500848_3501048	0.22	Ghr	growth hormone receptor	29304	0.23
chr13_62872928_62873142	0.22	Fbp1	fructose bisphosphatase 1	277	0.87
chr4_121078016_121078199	0.22	Zmpste24	zinc metallopeptidase, STE24	369	0.74
chr3_117078471_117078622	0.22	1700061I17Rik	RIKEN cDNA 1700061I17 gene	781	0.64
chr7_67658992_67659201	0.22	Ttc23	tetratricopeptide repeat domain 23	3649	0.17
chr17_15827084_15827313	0.22	Rgmb	repulsive guidance molecule family member B	612	0.68
chr9_64594586_64594757	0.22	Megf11	multiple EGF-like-domains 11	47772	0.15
chr9_109966945_109967106	0.22	Map4	microtubule-associated protein 4	1992	0.21
chr10_121349776_121349943	0.22	Gm48435	predicted gene, 48435	601	0.58
chr15_55043394_55043818	0.22	Taf2	TATA-box binding protein associated factor 2	2560	0.24
chr1_163817675_163817827	0.22	Kifap3	kinesin-associated protein 3	38168	0.16
chr6_24610042_24610446	0.22	Lmod2	leiomodin 2 (cardiac)	12482	0.14
chr19_39287276_39287531	0.22	Cyp2c29	cytochrome P450, family 2, subfamily c, polypeptide 29	329	0.91
chr2_146546861_146547083	0.22	4933406D12Rik	RIKEN cDNA 4933406D12 gene	4041	0.3
chr11_38774641_38774792	0.22	Gm23520	predicted gene, 23520	23561	0.29
chr1_172700535_172700739	0.22	Crp	C-reactive protein, pentraxin-related	2581	0.25
chr11_16834846_16835011	0.22	Egfros	epidermal growth factor receptor, opposite strand	4226	0.25
chr2_142767278_142767429	0.22	Gm22310	predicted gene, 22310	19543	0.24
chr7_97411671_97412103	0.22	Thrsp	thyroid hormone responsive	5632	0.13
chr13_24807889_24808047	0.22	Gm22358	predicted gene, 22358	3600	0.15
chr9_71176619_71176770	0.22	Gm32511	predicted gene, 32511	7918	0.18
chr11_120238015_120238347	0.21	Bahcc1	BAH domain and coiled-coil containing 1	1482	0.22
chr1_166738122_166738280	0.21	Gm4954	predicted gene 4954	23944	0.18
chr2_65212598_65212873	0.21	Cobll1	Cobl-like 1	23260	0.17
chr10_89635999_89636292	0.21	Slc17a8	solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 8	14892	0.17
chr2_154827673_154827835	0.21	Raly	hnRNP-associated with lethal yellow	36039	0.12
chr9_78290015_78290178	0.21	Gm10639	predicted gene 10639	168	0.9
chr19_7790468_7790619	0.21	Slc22a26	solute carrier family 22 (organic cation transporter), member 26	12035	0.17
chr8_94394237_94394701	0.21	Herpud1	homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1	938	0.39
chr19_10087853_10088030	0.21	Fads2	fatty acid desaturase 2	775	0.57
chr13_9097229_9097400	0.21	Larp4b	La ribonucleoprotein domain family, member 4B	3332	0.2
chr13_37278588_37278758	0.21	Gm47709	predicted gene, 47709	30013	0.13
chr6_51695515_51695666	0.21	Gm38811	predicted gene, 38811	15491	0.23
chr16_79086922_79087073	0.21	Tmprss15	transmembrane protease, serine 15	4095	0.35
chrX_77473868_77474135	0.21	Gm5937	predicted gene 5937	17415	0.21
chr7_119978745_119978903	0.21	Gm25217	predicted gene, 25217	9003	0.16
chr8_93245968_93246147	0.21	Gm45727	predicted gene 45727	5118	0.15
chr2_17326719_17326870	0.21	Nebl	nebulette	34292	0.22
chr5_150270318_150270506	0.21	Fry	FRY microtubule binding protein	10645	0.18
chr6_144895356_144895507	0.21	Gm22792	predicted gene, 22792	91799	0.07
chr6_51586079_51586243	0.21	Gm22914	predicted gene, 22914	35471	0.16
chr4_134814659_134814853	0.20	Maco1	macoilin 1	3543	0.24
chr2_75669473_75669624	0.20	Hnrnpa3	heterogeneous nuclear ribonucleoprotein A3	7059	0.13
chr1_21259850_21260251	0.20	Gsta3	glutathione S-transferase, alpha 3	6529	0.11
chr17_57219489_57219667	0.20	C3	complement component 3	394	0.74
chr3_10370926_10371217	0.20	Chmp4c	charged multivesicular body protein 4C	4113	0.15
chr9_55277952_55278103	0.20	Nrg4	neuregulin 4	5545	0.2

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of Prrx1_Isx_Prrxl1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.3	1.0	GO:1903800	positive regulation of production of miRNAs involved in gene silencing by miRNA(GO:1903800)
0.1	0.4	GO:0019626	short-chain fatty acid catabolic process(GO:0019626)
0.1	0.3	GO:0097167	circadian regulation of translation(GO:0097167)
0.1	0.3	GO:0034395	regulation of transcription from RNA polymerase II promoter in response to iron(GO:0034395)
0.1	0.3	GO:0060741	prostate gland stromal morphogenesis(GO:0060741)
0.1	0.4	GO:0046449	creatinine metabolic process(GO:0046449) cellular lactam metabolic process(GO:0072338)
0.1	0.3	GO:0006068	ethanol catabolic process(GO:0006068)
0.1	0.2	GO:1900245	positive regulation of MDA-5 signaling pathway(GO:1900245)
0.1	0.3	GO:2001013	epithelial cell proliferation involved in renal tubule morphogenesis(GO:2001013)
0.1	0.2	GO:0006538	glutamate catabolic process(GO:0006538)
0.1	0.3	GO:0071763	nuclear membrane organization(GO:0071763)
0.1	0.2	GO:0050882	voluntary musculoskeletal movement(GO:0050882)
0.1	0.2	GO:0030327	prenylated protein catabolic process(GO:0030327)
0.1	0.3	GO:0019856	'de novo' pyrimidine nucleobase biosynthetic process(GO:0006207) pyrimidine nucleobase biosynthetic process(GO:0019856)
0.1	0.1	GO:0018879	biphenyl metabolic process(GO:0018879)
0.1	0.6	GO:0009404	toxin metabolic process(GO:0009404)
0.1	0.2	GO:1904154	positive regulation of retrograde protein transport, ER to cytosol(GO:1904154)
0.0	0.1	GO:0016554	cytidine to uridine editing(GO:0016554)
0.0	0.0	GO:0006714	sesquiterpenoid metabolic process(GO:0006714)
0.0	0.1	GO:2000211	regulation of glutamate metabolic process(GO:2000211)
0.0	0.2	GO:0071286	cellular response to magnesium ion(GO:0071286)
0.0	0.4	GO:0048304	positive regulation of isotype switching to IgG isotypes(GO:0048304)
0.0	0.3	GO:0060613	fat pad development(GO:0060613)
0.0	0.1	GO:0032380	regulation of intracellular lipid transport(GO:0032377) regulation of intracellular sterol transport(GO:0032380) regulation of intracellular cholesterol transport(GO:0032383)
0.0	0.2	GO:0070327	thyroid hormone transport(GO:0070327)
0.0	0.1	GO:0060523	prostate epithelial cord elongation(GO:0060523)
0.0	0.1	GO:0006987	activation of signaling protein activity involved in unfolded protein response(GO:0006987)
0.0	0.3	GO:0051657	maintenance of organelle location(GO:0051657)
0.0	0.2	GO:0042737	drug catabolic process(GO:0042737)
0.0	0.1	GO:0001794	type IIa hypersensitivity(GO:0001794) regulation of type IIa hypersensitivity(GO:0001796) positive regulation of type IIa hypersensitivity(GO:0001798) type II hypersensitivity(GO:0002445) regulation of type II hypersensitivity(GO:0002892) positive regulation of type II hypersensitivity(GO:0002894)
0.0	0.1	GO:1902915	negative regulation of protein K63-linked ubiquitination(GO:1900045) negative regulation of protein polyubiquitination(GO:1902915)
0.0	0.1	GO:0090219	negative regulation of lipid kinase activity(GO:0090219)
0.0	0.1	GO:0045900	negative regulation of translational elongation(GO:0045900)
0.0	0.1	GO:0044597	polyketide metabolic process(GO:0030638) aminoglycoside antibiotic metabolic process(GO:0030647) daunorubicin metabolic process(GO:0044597) doxorubicin metabolic process(GO:0044598)
0.0	0.0	GO:0006533	aspartate catabolic process(GO:0006533)
0.0	0.1	GO:0070213	protein auto-ADP-ribosylation(GO:0070213)
0.0	0.1	GO:0034310	primary alcohol catabolic process(GO:0034310)
0.0	0.1	GO:1903232	melanosome assembly(GO:1903232)
0.0	0.2	GO:0021778	oligodendrocyte cell fate specification(GO:0021778) oligodendrocyte cell fate commitment(GO:0021779) glial cell fate specification(GO:0021780)
0.0	0.1	GO:0003162	atrioventricular node development(GO:0003162)
0.0	0.1	GO:0044337	canonical Wnt signaling pathway involved in positive regulation of apoptotic process(GO:0044337)
0.0	0.1	GO:0070672	response to interleukin-15(GO:0070672)
0.0	0.1	GO:0006578	amino-acid betaine biosynthetic process(GO:0006578)
0.0	0.1	GO:0015014	heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0015014)
0.0	0.1	GO:1903690	negative regulation of wound healing, spreading of epidermal cells(GO:1903690)
0.0	0.1	GO:0045719	negative regulation of glycogen biosynthetic process(GO:0045719)
0.0	0.1	GO:0009629	response to gravity(GO:0009629)
0.0	0.2	GO:0030718	germ-line stem cell population maintenance(GO:0030718)
0.0	0.3	GO:0070050	neuron cellular homeostasis(GO:0070050)
0.0	0.1	GO:0038026	reelin-mediated signaling pathway(GO:0038026)
0.0	0.1	GO:1903587	regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:1903587)
0.0	0.7	GO:0019373	epoxygenase P450 pathway(GO:0019373)
0.0	0.1	GO:0097118	neuroligin clustering involved in postsynaptic membrane assembly(GO:0097118)
0.0	0.1	GO:0042706	eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate commitment(GO:0046552)
0.0	0.1	GO:1903334	positive regulation of protein folding(GO:1903334)
0.0	0.1	GO:1901078	negative regulation of relaxation of muscle(GO:1901078)
0.0	0.0	GO:1904261	regulation of basement membrane assembly involved in embryonic body morphogenesis(GO:1904259) positive regulation of basement membrane assembly involved in embryonic body morphogenesis(GO:1904261) basement membrane assembly involved in embryonic body morphogenesis(GO:2001197)
0.0	0.1	GO:0006931	substrate-dependent cell migration, cell attachment to substrate(GO:0006931)
0.0	0.1	GO:0060447	bud outgrowth involved in lung branching(GO:0060447)
0.0	0.1	GO:1900227	positive regulation of NLRP3 inflammasome complex assembly(GO:1900227)
0.0	0.1	GO:0072602	interleukin-4 secretion(GO:0072602)
0.0	0.2	GO:0070493	thrombin receptor signaling pathway(GO:0070493)
0.0	0.1	GO:0045200	establishment or maintenance of neuroblast polarity(GO:0045196) establishment of neuroblast polarity(GO:0045200)
0.0	0.1	GO:0061010	gall bladder development(GO:0061010)
0.0	0.1	GO:0048478	replication fork protection(GO:0048478)
0.0	0.0	GO:0060174	limb bud formation(GO:0060174)
0.0	0.0	GO:1990705	cholangiocyte proliferation(GO:1990705)
0.0	0.1	GO:1903071	positive regulation of ER-associated ubiquitin-dependent protein catabolic process(GO:1903071)
0.0	0.1	GO:0003330	regulation of extracellular matrix constituent secretion(GO:0003330) positive regulation of extracellular matrix constituent secretion(GO:0003331)
0.0	0.1	GO:0061366	behavioral response to chemical pain(GO:0061366) behavioral response to formalin induced pain(GO:0061368)
0.0	0.1	GO:2000370	positive regulation of clathrin-mediated endocytosis(GO:2000370)
0.0	0.1	GO:0048550	negative regulation of pinocytosis(GO:0048550)
0.0	0.2	GO:0000463	maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000463)
0.0	0.1	GO:0060903	positive regulation of meiosis I(GO:0060903)
0.0	0.1	GO:0060051	negative regulation of protein glycosylation(GO:0060051)
0.0	0.1	GO:0035865	response to potassium ion(GO:0035864) cellular response to potassium ion(GO:0035865)
0.0	0.1	GO:0001880	Mullerian duct regression(GO:0001880)
0.0	0.0	GO:0060913	cardiac cell fate determination(GO:0060913)
0.0	0.1	GO:1900042	positive regulation of interleukin-2 secretion(GO:1900042)
0.0	0.2	GO:0006013	mannose metabolic process(GO:0006013)
0.0	0.1	GO:1904694	negative regulation of vascular smooth muscle contraction(GO:1904694)
0.0	0.1	GO:0033092	positive regulation of immature T cell proliferation in thymus(GO:0033092)
0.0	0.0	GO:1904742	regulation of telomeric DNA binding(GO:1904742)
0.0	0.0	GO:0036023	limb joint morphogenesis(GO:0036022) embryonic skeletal limb joint morphogenesis(GO:0036023)
0.0	0.1	GO:0042373	vitamin K metabolic process(GO:0042373)
0.0	0.1	GO:1902309	negative regulation of peptidyl-serine dephosphorylation(GO:1902309)
0.0	0.1	GO:0097105	presynaptic membrane assembly(GO:0097105)
0.0	0.2	GO:0009109	coenzyme catabolic process(GO:0009109)
0.0	0.0	GO:0030397	membrane disassembly(GO:0030397) nuclear envelope disassembly(GO:0051081)
0.0	0.1	GO:0042126	nitrate metabolic process(GO:0042126)
0.0	0.0	GO:1900157	regulation of bone mineralization involved in bone maturation(GO:1900157)
0.0	0.0	GO:2000807	regulation of synaptic vesicle clustering(GO:2000807)
0.0	0.1	GO:0060528	secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development(GO:0060528)
0.0	0.1	GO:0034227	tRNA thio-modification(GO:0034227)
0.0	0.1	GO:0010724	regulation of definitive erythrocyte differentiation(GO:0010724)
0.0	0.1	GO:0060916	mesenchymal cell proliferation involved in lung development(GO:0060916)
0.0	0.0	GO:0017187	peptidyl-glutamic acid carboxylation(GO:0017187)
0.0	0.0	GO:0032741	positive regulation of interleukin-18 production(GO:0032741)
0.0	0.1	GO:1902109	negative regulation of mitochondrial membrane permeability involved in apoptotic process(GO:1902109)
0.0	0.1	GO:0032252	secretory granule localization(GO:0032252)
0.0	0.4	GO:0043252	sodium-independent organic anion transport(GO:0043252)
0.0	0.0	GO:0097051	establishment of protein localization to endoplasmic reticulum membrane(GO:0097051)
0.0	0.0	GO:0060300	regulation of cytokine activity(GO:0060300)
0.0	0.0	GO:0036493	positive regulation of translation in response to endoplasmic reticulum stress(GO:0036493)
0.0	0.3	GO:0010569	regulation of double-strand break repair via homologous recombination(GO:0010569)
0.0	0.0	GO:0006001	fructose catabolic process(GO:0006001) fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate(GO:0061624) glycolytic process through fructose-1-phosphate(GO:0061625)
0.0	0.2	GO:0051481	negative regulation of cytosolic calcium ion concentration(GO:0051481)
0.0	0.1	GO:2000766	negative regulation of cytoplasmic translation(GO:2000766)
0.0	0.0	GO:0006982	response to lipid hydroperoxide(GO:0006982)
0.0	0.0	GO:0070782	phosphatidylserine exposure on apoptotic cell surface(GO:0070782)
0.0	0.0	GO:0035054	embryonic heart tube anterior/posterior pattern specification(GO:0035054)
0.0	0.0	GO:0061470	T follicular helper cell differentiation(GO:0061470)
0.0	0.1	GO:2000189	positive regulation of cholesterol homeostasis(GO:2000189)
0.0	0.1	GO:0098908	regulation of neuronal action potential(GO:0098908)
0.0	0.0	GO:0033387	putrescine biosynthetic process from ornithine(GO:0033387)
0.0	0.2	GO:0003334	keratinocyte development(GO:0003334)
0.0	0.1	GO:0060161	positive regulation of dopamine receptor signaling pathway(GO:0060161)
0.0	0.0	GO:0045080	positive regulation of chemokine biosynthetic process(GO:0045080)
0.0	0.0	GO:0090283	regulation of protein glycosylation in Golgi(GO:0090283)
0.0	0.2	GO:0033147	negative regulation of intracellular estrogen receptor signaling pathway(GO:0033147)
0.0	0.1	GO:1902036	regulation of hematopoietic stem cell differentiation(GO:1902036)
0.0	0.1	GO:0051005	negative regulation of lipoprotein lipase activity(GO:0051005)
0.0	0.1	GO:0002072	optic cup morphogenesis involved in camera-type eye development(GO:0002072)
0.0	0.0	GO:0035482	gastric motility(GO:0035482)
0.0	0.1	GO:0018243	protein O-linked glycosylation via threonine(GO:0018243)
0.0	0.1	GO:0016127	cholesterol catabolic process(GO:0006707) sterol catabolic process(GO:0016127)
0.0	0.1	GO:1902018	negative regulation of cilium assembly(GO:1902018)
0.0	0.0	GO:0006556	S-adenosylmethionine biosynthetic process(GO:0006556)
0.0	0.1	GO:0006573	valine metabolic process(GO:0006573)
0.0	0.0	GO:0002215	defense response to nematode(GO:0002215)
0.0	0.1	GO:0035507	regulation of myosin-light-chain-phosphatase activity(GO:0035507)
0.0	0.1	GO:0048852	diencephalon morphogenesis(GO:0048852)
0.0	0.1	GO:2000096	positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096)
0.0	0.0	GO:0001831	trophectodermal cellular morphogenesis(GO:0001831)
0.0	0.0	GO:0002036	regulation of L-glutamate transport(GO:0002036)
0.0	0.1	GO:1901339	regulation of store-operated calcium channel activity(GO:1901339)
0.0	0.0	GO:0035283	central nervous system segmentation(GO:0035283) brain segmentation(GO:0035284)
0.0	0.0	GO:0060178	regulation of exocyst localization(GO:0060178)
0.0	0.1	GO:0052697	xenobiotic glucuronidation(GO:0052697)
0.0	0.1	GO:0015871	choline transport(GO:0015871)
0.0	0.0	GO:0048022	negative regulation of melanin biosynthetic process(GO:0048022) negative regulation of secondary metabolite biosynthetic process(GO:1900377)
0.0	0.0	GO:2000302	positive regulation of synaptic vesicle exocytosis(GO:2000302)
0.0	0.0	GO:0006651	diacylglycerol biosynthetic process(GO:0006651)
0.0	0.1	GO:0043247	protection from non-homologous end joining at telomere(GO:0031848) telomere maintenance in response to DNA damage(GO:0043247)
0.0	0.3	GO:0032728	positive regulation of interferon-beta production(GO:0032728)
0.0	0.0	GO:0070100	negative regulation of chemokine-mediated signaling pathway(GO:0070100)
0.0	0.0	GO:0015747	urate transport(GO:0015747)
0.0	0.0	GO:0048291	isotype switching to IgG isotypes(GO:0048291)
0.0	0.1	GO:0006528	asparagine metabolic process(GO:0006528)
0.0	0.1	GO:1900103	positive regulation of endoplasmic reticulum unfolded protein response(GO:1900103)
0.0	0.0	GO:0075509	receptor-mediated endocytosis of virus by host cell(GO:0019065) endocytosis involved in viral entry into host cell(GO:0075509)
0.0	0.0	GO:0010040	response to iron(II) ion(GO:0010040)
0.0	0.0	GO:0048696	regulation of collateral sprouting in absence of injury(GO:0048696)
0.0	0.0	GO:1900044	regulation of protein K63-linked ubiquitination(GO:1900044)
0.0	0.0	GO:1900084	regulation of peptidyl-tyrosine autophosphorylation(GO:1900084) positive regulation of peptidyl-tyrosine autophosphorylation(GO:1900086)
0.0	0.0	GO:0032439	endosome localization(GO:0032439)
0.0	0.1	GO:0010891	negative regulation of sequestering of triglyceride(GO:0010891)
0.0	0.0	GO:1902809	regulation of skeletal muscle fiber differentiation(GO:1902809)
0.0	0.0	GO:0035799	ureter maturation(GO:0035799)
0.0	0.0	GO:0006166	purine ribonucleoside salvage(GO:0006166)
0.0	0.0	GO:0046083	adenine metabolic process(GO:0046083) adenine biosynthetic process(GO:0046084)
0.0	0.2	GO:0045056	transcytosis(GO:0045056)
0.0	0.0	GO:0007181	transforming growth factor beta receptor complex assembly(GO:0007181)
0.0	0.1	GO:0009052	pentose-phosphate shunt, non-oxidative branch(GO:0009052)
0.0	0.0	GO:0070669	response to interleukin-2(GO:0070669)
0.0	0.0	GO:0060283	negative regulation of oocyte development(GO:0060283) negative regulation of oocyte maturation(GO:1900194)
0.0	0.0	GO:0042524	negative regulation of tyrosine phosphorylation of Stat5 protein(GO:0042524)
0.0	0.1	GO:0042985	negative regulation of amyloid precursor protein biosynthetic process(GO:0042985)
0.0	0.0	GO:2000301	negative regulation of synaptic vesicle exocytosis(GO:2000301)
0.0	0.1	GO:0006388	tRNA splicing, via endonucleolytic cleavage and ligation(GO:0006388)
0.0	0.0	GO:0000350	generation of catalytic spliceosome for second transesterification step(GO:0000350)
0.0	0.0	GO:0046416	D-amino acid metabolic process(GO:0046416)
0.0	0.1	GO:0006283	transcription-coupled nucleotide-excision repair(GO:0006283)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.3	1.0	GO:0097487	multivesicular body, internal vesicle(GO:0097487)
0.1	0.3	GO:0002177	manchette(GO:0002177)
0.1	0.2	GO:0031088	platelet dense granule membrane(GO:0031088)
0.0	0.2	GO:0070545	PeBoW complex(GO:0070545)
0.0	0.2	GO:0035867	alphav-beta3 integrin-IGF-1-IGF1R complex(GO:0035867)
0.0	0.2	GO:0045098	type III intermediate filament(GO:0045098)
0.0	0.1	GO:0097413	Lewy body(GO:0097413)
0.0	0.2	GO:0097197	tetraspanin-enriched microdomain(GO:0097197)
0.0	0.1	GO:0097441	basilar dendrite(GO:0097441)
0.0	0.3	GO:1990124	messenger ribonucleoprotein complex(GO:1990124)
0.0	0.1	GO:0033186	CAF-1 complex(GO:0033186)
0.0	0.1	GO:0005899	insulin receptor complex(GO:0005899)
0.0	0.1	GO:0002193	MAML1-RBP-Jkappa- ICN1 complex(GO:0002193)
0.0	0.1	GO:0044316	cone cell pedicle(GO:0044316)
0.0	0.1	GO:0045180	basal cortex(GO:0045180)
0.0	0.1	GO:0005896	interleukin-6 receptor complex(GO:0005896)
0.0	0.1	GO:0070033	synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex(GO:0070033)
0.0	0.1	GO:0031315	extrinsic component of mitochondrial outer membrane(GO:0031315)
0.0	0.1	GO:0072357	PTW/PP1 phosphatase complex(GO:0072357)
0.0	0.1	GO:0030868	smooth endoplasmic reticulum membrane(GO:0030868) smooth endoplasmic reticulum part(GO:0097425)
0.0	0.1	GO:0032541	cortical endoplasmic reticulum(GO:0032541)
0.0	0.1	GO:1990075	periciliary membrane compartment(GO:1990075)
0.0	0.1	GO:0000808	origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
0.0	0.1	GO:0045293	mRNA editing complex(GO:0045293)
0.0	0.1	GO:0072669	tRNA-splicing ligase complex(GO:0072669)
0.0	0.0	GO:0097454	Schwann cell microvillus(GO:0097454)
0.0	0.0	GO:0071008	U2-type post-mRNA release spliceosomal complex(GO:0071008)
0.0	0.2	GO:0030877	beta-catenin destruction complex(GO:0030877)
0.0	0.0	GO:0071664	catenin-TCF7L2 complex(GO:0071664)
0.0	0.3	GO:0005790	smooth endoplasmic reticulum(GO:0005790)
0.0	0.1	GO:0008091	spectrin(GO:0008091)
0.0	0.1	GO:0001527	microfibril(GO:0001527)
0.0	0.0	GO:0044615	nuclear pore nuclear basket(GO:0044615)
0.0	0.1	GO:0016342	catenin complex(GO:0016342)
0.0	0.1	GO:0097433	dense body(GO:0097433)
0.0	0.5	GO:0009295	nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.0	0.1	GO:0016012	sarcoglycan complex(GO:0016012)
0.0	0.0	GO:0030478	actin cap(GO:0030478)
0.0	0.0	GO:0030127	COPII vesicle coat(GO:0030127)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.3	1.0	GO:0048408	epidermal growth factor binding(GO:0048408)
0.1	0.3	GO:0016743	carboxyl- or carbamoyltransferase activity(GO:0016743)
0.1	0.4	GO:0034875	oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor(GO:0033695) caffeine oxidase activity(GO:0034875)
0.1	0.2	GO:0005220	inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.1	0.2	GO:0003986	acetyl-CoA hydrolase activity(GO:0003986)
0.1	0.5	GO:0004499	N,N-dimethylaniline monooxygenase activity(GO:0004499)
0.1	0.3	GO:0070728	leucine binding(GO:0070728)
0.1	0.3	GO:0004769	steroid delta-isomerase activity(GO:0004769)
0.1	0.2	GO:0070538	oleic acid binding(GO:0070538)
0.0	0.1	GO:0004024	alcohol dehydrogenase activity, zinc-dependent(GO:0004024)
0.0	0.3	GO:0003680	AT DNA binding(GO:0003680)
0.0	0.1	GO:0004771	sterol esterase activity(GO:0004771)
0.0	0.2	GO:0015093	ferrous iron transmembrane transporter activity(GO:0015093)
0.0	0.2	GO:0016899	oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor(GO:0016899)
0.0	0.4	GO:0008568	microtubule-severing ATPase activity(GO:0008568)
0.0	0.3	GO:0004571	mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.0	0.1	GO:0070644	vitamin D response element binding(GO:0070644)
0.0	0.1	GO:0018479	benzaldehyde dehydrogenase (NAD+) activity(GO:0018479)
0.0	0.1	GO:0038181	bile acid receptor activity(GO:0038181)
0.0	0.1	GO:0047045	testosterone 17-beta-dehydrogenase (NADP+) activity(GO:0047045)
0.0	0.1	GO:0016716	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen(GO:0016716)
0.0	0.1	GO:0001069	regulatory region RNA binding(GO:0001069)
0.0	0.1	GO:0009374	biotin binding(GO:0009374)
0.0	0.2	GO:0008508	bile acid:sodium symporter activity(GO:0008508)
0.0	0.1	GO:0047961	glycine N-acyltransferase activity(GO:0047961)
0.0	0.1	GO:0050508	glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity(GO:0050508)
0.0	0.1	GO:0000386	second spliceosomal transesterification activity(GO:0000386)
0.0	0.2	GO:0004768	stearoyl-CoA 9-desaturase activity(GO:0004768)
0.0	0.3	GO:0050308	sugar-phosphatase activity(GO:0050308)
0.0	0.1	GO:0005168	neurotrophin TRKA receptor binding(GO:0005168)
0.0	0.1	GO:0004345	glucose-6-phosphate dehydrogenase activity(GO:0004345)
0.0	0.1	GO:0004566	beta-glucuronidase activity(GO:0004566)
0.0	0.1	GO:2001070	starch binding(GO:2001070)
0.0	0.2	GO:0000900	translation repressor activity, nucleic acid binding(GO:0000900)
0.0	0.2	GO:0043798	cobinamide kinase activity(GO:0008819) phytol kinase activity(GO:0010276) phenol kinase activity(GO:0018720) cyclin-dependent protein kinase activating kinase regulator activity(GO:0019914) inositol tetrakisphosphate 2-kinase activity(GO:0032942) heptose 7-phosphate kinase activity(GO:0033785) aminoglycoside phosphotransferase activity(GO:0034071) eukaryotic elongation factor-2 kinase regulator activity(GO:0042556) eukaryotic elongation factor-2 kinase activator activity(GO:0042557) LPPG:FO 2-phospho-L-lactate transferase activity(GO:0043743) cytidine kinase activity(GO:0043771) glycerate 2-kinase activity(GO:0043798) (S)-lactate 2-kinase activity(GO:0043841) phosphoserine:homoserine phosphotransferase activity(GO:0043899) L-seryl-tRNA(Sec) kinase activity(GO:0043915) phosphocholine transferase activity(GO:0044605) GTP-dependent polynucleotide kinase activity(GO:0051735) farnesol kinase activity(GO:0052668) CTP:2-trans,-6-trans-farnesol kinase activity(GO:0052669) geraniol kinase activity(GO:0052670) geranylgeraniol kinase activity(GO:0052671) CTP:geranylgeraniol kinase activity(GO:0052672) prenol kinase activity(GO:0052673) 1-phosphatidylinositol-5-kinase activity(GO:0052810) 1-phosphatidylinositol-3-phosphate 4-kinase activity(GO:0052811) phosphatidylinositol-3,4-bisphosphate 5-kinase activity(GO:0052812) inositol-3,4,6-trisphosphate 1-kinase activity(GO:0052835) inositol 5-diphosphate pentakisphosphate 5-kinase activity(GO:0052836) inositol diphosphate tetrakisphosphate kinase activity(GO:0052839)
0.0	0.1	GO:0031697	beta-1 adrenergic receptor binding(GO:0031697)
0.0	0.1	GO:0004505	phenylalanine 4-monooxygenase activity(GO:0004505)
0.0	0.1	GO:0015288	porin activity(GO:0015288)
0.0	0.1	GO:0004090	carbonyl reductase (NADPH) activity(GO:0004090)
0.0	0.1	GO:0030229	very-low-density lipoprotein particle receptor activity(GO:0030229)
0.0	0.1	GO:0030284	estrogen receptor activity(GO:0030284)
0.0	0.1	GO:0035312	5'-3' exodeoxyribonuclease activity(GO:0035312)
0.0	0.1	GO:0016509	long-chain-3-hydroxyacyl-CoA dehydrogenase activity(GO:0016509)
0.0	0.2	GO:0005159	insulin-like growth factor receptor binding(GO:0005159)
0.0	0.2	GO:0051787	misfolded protein binding(GO:0051787)
0.0	0.1	GO:0047760	butyrate-CoA ligase activity(GO:0047760)
0.0	0.1	GO:0050815	phosphoserine binding(GO:0050815)
0.0	0.0	GO:0004022	alcohol dehydrogenase (NAD) activity(GO:0004022)
0.0	0.1	GO:0005007	fibroblast growth factor-activated receptor activity(GO:0005007)
0.0	0.0	GO:0004948	calcitonin receptor activity(GO:0004948)
0.0	0.1	GO:0004514	nicotinate-nucleotide diphosphorylase (carboxylating) activity(GO:0004514)
0.0	0.1	GO:0003846	2-acylglycerol O-acyltransferase activity(GO:0003846)
0.0	0.4	GO:0015347	sodium-independent organic anion transmembrane transporter activity(GO:0015347)
0.0	0.0	GO:0032190	acrosin binding(GO:0032190)
0.0	0.0	GO:0005345	purine nucleobase transmembrane transporter activity(GO:0005345) pyrimidine nucleobase transmembrane transporter activity(GO:0005350) nucleobase transmembrane transporter activity(GO:0015205)
0.0	0.0	GO:0043423	3-phosphoinositide-dependent protein kinase binding(GO:0043423)
0.0	0.3	GO:0016864	protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864)
0.0	0.1	GO:0071614	linoleic acid epoxygenase activity(GO:0071614)
0.0	0.1	GO:0016401	palmitoyl-CoA oxidase activity(GO:0016401)
0.0	0.2	GO:0008195	phosphatidate phosphatase activity(GO:0008195)
0.0	0.4	GO:0001205	transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.0	0.0	GO:0034191	apolipoprotein A-I receptor binding(GO:0034191)
0.0	0.1	GO:0015220	choline transmembrane transporter activity(GO:0015220)
0.0	0.1	GO:0043338	CTP:2,3-di-O-geranylgeranyl-sn-glycero-1-phosphate cytidyltransferase activity(GO:0043338) phospholactate guanylyltransferase activity(GO:0043814) ATP:coenzyme F420 adenylyltransferase activity(GO:0043910) UDP-N-acetylgalactosamine diphosphorylase activity(GO:0052630)
0.0	0.0	GO:0051033	nucleic acid transmembrane transporter activity(GO:0051032) RNA transmembrane transporter activity(GO:0051033)
0.0	0.1	GO:0097322	7SK snRNA binding(GO:0097322)
0.0	0.5	GO:0051723	protein methylesterase activity(GO:0051723)
0.0	0.0	GO:0043559	insulin binding(GO:0043559)
0.0	0.1	GO:0008239	dipeptidyl-peptidase activity(GO:0008239)
0.0	0.1	GO:0071933	Arp2/3 complex binding(GO:0071933)
0.0	0.1	GO:0004652	polynucleotide adenylyltransferase activity(GO:0004652)
0.0	0.1	GO:0008948	oxaloacetate decarboxylase activity(GO:0008948)
0.0	0.1	GO:0005072	transforming growth factor beta receptor, cytoplasmic mediator activity(GO:0005072)
0.0	0.1	GO:0043426	MRF binding(GO:0043426)
0.0	0.5	GO:0017046	peptide hormone binding(GO:0017046)
0.0	0.0	GO:0098748	clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)
0.0	0.4	GO:0045502	dynein binding(GO:0045502)
0.0	0.0	GO:0004332	fructose-bisphosphate aldolase activity(GO:0004332)
0.0	0.0	GO:0044020	histone methyltransferase activity (H4-R3 specific)(GO:0044020)
0.0	0.0	GO:0051525	NFAT protein binding(GO:0051525)
0.0	0.1	GO:0004908	interleukin-1 receptor activity(GO:0004908)
0.0	0.1	GO:0004859	phospholipase inhibitor activity(GO:0004859)
0.0	0.0	GO:0003941	L-serine ammonia-lyase activity(GO:0003941)
0.0	0.0	GO:0005173	stem cell factor receptor binding(GO:0005173)
0.0	0.1	GO:0008474	palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.0	0.2	GO:0015269	calcium-activated potassium channel activity(GO:0015269)
0.0	0.2	GO:0015026	coreceptor activity(GO:0015026)
0.0	0.1	GO:0036122	BMP binding(GO:0036122)
0.0	0.1	GO:0004723	calcium-dependent protein serine/threonine phosphatase activity(GO:0004723)
0.0	0.0	GO:0042030	ATPase inhibitor activity(GO:0042030)
0.0	0.2	GO:0015924	mannosyl-oligosaccharide mannosidase activity(GO:0015924)
0.0	0.1	GO:0042979	ornithine decarboxylase regulator activity(GO:0042979)
0.0	0.0	GO:0004416	hydroxyacylglutathione hydrolase activity(GO:0004416)
0.0	0.0	GO:0016635	oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor(GO:0016635)
0.0	0.1	GO:0070324	thyroid hormone binding(GO:0070324)
0.0	0.0	GO:0055100	adiponectin binding(GO:0055100)
0.0	0.1	GO:0002162	dystroglycan binding(GO:0002162)
0.0	0.1	GO:0016679	oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679)
0.0	0.0	GO:0004616	phosphogluconate dehydrogenase (decarboxylating) activity(GO:0004616)
0.0	0.1	GO:0019869	chloride channel inhibitor activity(GO:0019869)
0.0	0.0	GO:0045134	uridine-diphosphatase activity(GO:0045134)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	1.2	PID ERBB NETWORK PATHWAY	ErbB receptor signaling network
0.0	0.7	PID HEDGEHOG GLI PATHWAY	Hedgehog signaling events mediated by Gli proteins
0.0	0.0	ST GA13 PATHWAY	G alpha 13 Pathway
0.0	0.3	PID IGF1 PATHWAY	IGF1 pathway
0.0	0.5	PID HES HEY PATHWAY	Notch-mediated HES/HEY network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	1.0	REACTOME SIGNALING BY CONSTITUTIVELY ACTIVE EGFR	Genes involved in Signaling by constitutively active EGFR
0.0	0.4	REACTOME PROLACTIN RECEPTOR SIGNALING	Genes involved in Prolactin receptor signaling
0.0	0.3	REACTOME ALPHA LINOLENIC ACID ALA METABOLISM	Genes involved in alpha-linolenic acid (ALA) metabolism
0.0	0.3	REACTOME CALNEXIN CALRETICULIN CYCLE	Genes involved in Calnexin/calreticulin cycle
0.0	0.1	REACTOME ETHANOL OXIDATION	Genes involved in Ethanol oxidation
0.0	0.3	REACTOME ENDOGENOUS STEROLS	Genes involved in Endogenous sterols
0.0	0.1	REACTOME XENOBIOTICS	Genes involved in Xenobiotics
0.0	0.2	REACTOME RECYCLING OF BILE ACIDS AND SALTS	Genes involved in Recycling of bile acids and salts
0.0	0.4	REACTOME PHASE1 FUNCTIONALIZATION OF COMPOUNDS	Genes involved in Phase 1 - Functionalization of compounds
0.0	0.2	REACTOME FATTY ACYL COA BIOSYNTHESIS	Genes involved in Fatty Acyl-CoA Biosynthesis
0.0	0.2	REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC	Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.0	0.2	REACTOME SHC1 EVENTS IN ERBB4 SIGNALING	Genes involved in SHC1 events in ERBB4 signaling
0.0	0.1	REACTOME E2F ENABLED INHIBITION OF PRE REPLICATION COMPLEX FORMATION	Genes involved in E2F-enabled inhibition of pre-replication complex formation
0.0	0.4	REACTOME REGULATION OF BETA CELL DEVELOPMENT	Genes involved in Regulation of beta-cell development
0.0	0.1	REACTOME SIGNAL ATTENUATION	Genes involved in Signal attenuation
0.0	0.2	REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION	Genes involved in Amino acid synthesis and interconversion (transamination)
0.0	0.0	REACTOME OLFACTORY SIGNALING PATHWAY	Genes involved in Olfactory Signaling Pathway
0.0	0.1	REACTOME RAP1 SIGNALLING	Genes involved in Rap1 signalling
0.0	0.3	REACTOME GLUCONEOGENESIS	Genes involved in Gluconeogenesis
0.0	0.0	REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION	Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.0	0.1	REACTOME SYNTHESIS OF PE	Genes involved in Synthesis of PE

Results for Prrx1_Isx_Prrxl1

Z-value: 0.77

Motif logo

Transcription factors associated with Prrx1_Isx_Prrxl1

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

Activity of the Prrx1_Isx_Prrxl1 motif across conditions

Conditions sorted by the z-value of the Prrx1_Isx_Prrxl1 motif activity

Top target CREs of the motif:

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of Prrx1_Isx_Prrxl1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: