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ENCSR904DTN: DNase-seq of mouse liver in constant darkness
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Results for Rarb

Z-value: 1.93

Motif logo

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Transcription factors associated with Rarb

Gene Symbol Gene ID Gene Info
Rarb
ENSMUSG00000017491.8 retinoic acid receptor, beta

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE Gene Distance Association probability Pearson corr. coef. P-value Plot
chr14_16573210_16573389Rarb17460.364795-0.962.7e-03Click!
chr14_16572962_16573173Rarb19780.340832-0.953.0e-03Click!
chr14_16570330_16570481Rarb46400.249769-0.945.4e-03Click!
chr14_16735456_16735607Rarb834740.1001500.937.4e-03Click!
chr14_16575472_16575639Rarb120.5174560.901.4e-02Click!

Activity of the Rarb motif across conditions

Conditions sorted by the z-value of the Rarb motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE) Target Score Top associated gene Gene Info Distance of CRE to TSS CRE/Gene association probability
chr12_71429918_71430089 2.70 1700083H02Rik
 RIKEN cDNA 1700083H02 gene
 45795
 0.12
chr8_94217878_94218059 2.51 Nup93
 nucleoporin 93
 3362
 0.14
chr4_150287636_150287787 2.18 Rere
 arginine glutamic acid dipeptide (RE) repeats
 5899
 0.16
chr6_89138858_89139017 1.91 Gm1965
 predicted gene 1965
 2057
 0.29
chr11_50733265_50733435 1.83 Gm12200
 predicted gene 12200
 7806
 0.16
chr2_114776001_114776450 1.78 Gm13975
 predicted gene 13975
 68113
 0.11
chr3_104541230_104541625 1.77 Lrig2
 leucine-rich repeats and immunoglobulin-like domains 2
 29509
 0.1
chr4_43234117_43234284 1.66 Unc13b
 unc-13 homolog B
 393
 0.84
chr5_118292276_118292427 1.66 Gm25076
 predicted gene, 25076
 25902
 0.16
chr14_51102456_51102668 1.60 Rnase4
 ribonuclease, RNase A family 4
 6203
 0.08
chr8_115644414_115644565 1.48 Gm23677
 predicted gene, 23677
 53216
 0.13
chr5_88969041_88969210 1.38 Slc4a4
 solute carrier family 4 (anion exchanger), member 4
 34553
 0.2
chr19_21038157_21038331 1.36 4930554I06Rik
 RIKEN cDNA 4930554I06 gene
 66258
 0.11
chr8_124345179_124345346 1.32 Gm24459
 predicted gene, 24459
 11976
 0.14
chr5_146107597_146107748 1.19 Cyp3a59
 cytochrome P450, family 3, subfamily a, polypeptide 59
 28405
 0.11
chr19_47385384_47385539 1.17 Sh3pxd2a
 SH3 and PX domains 2A
 24898
 0.18
chr17_56470625_56470795 1.16 Ptprs
 protein tyrosine phosphatase, receptor type, S
 3917
 0.18
chr5_121730204_121730378 1.08 Gm16552
 predicted gene 16552
 2888
 0.16
chr13_40913304_40913608 1.06 Gm48188
 predicted gene, 48188
 1249
 0.3
chr10_84055512_84055676 1.06 Gm37908
 predicted gene, 37908
 6164
 0.21
chr13_79286283_79286457 1.05 Gm29318
 predicted gene 29318
 658
 0.76
chr4_3736363_3736519 1.04 Gm11805
 predicted gene 11805
 15415
 0.15
chr9_109115339_109115519 1.03 Plxnb1
 plexin B1
 8635
 0.1
chrX_42066716_42066867 1.02 Xiap
 X-linked inhibitor of apoptosis
 1045
 0.59
chrX_101391513_101391680 0.99 Gjb1
 gap junction protein, beta 1
 7860
 0.14
chr2_69415195_69415364 0.99 Dhrs9
 dehydrogenase/reductase (SDR family) member 9
 34834
 0.16
chr1_75662127_75662446 0.99 Gm5257
 predicted gene 5257
 25896
 0.15
chr5_64883553_64883984 0.99 AC161757.1
 toll-like receptor 1 (Tlr1) pseudogene
 15201
 0.15
chr8_39639786_39639944 0.98 Msr1
 macrophage scavenger receptor 1
 2755
 0.39
chr5_122693537_122693811 0.98 Gm10064
 predicted gene 10064
 3926
 0.14
chr4_141280593_141280762 0.97 Gm13056
 predicted gene 13056
 2238
 0.18
chr17_24797110_24797261 0.96 Meiob
 meiosis specific with OB domains
 7104
 0.09
chr10_34136560_34136736 0.91 Calhm6
 calcium homeostasis modulator family member 6
 8664
 0.13
chr15_26377246_26377425 0.91 Marchf11
 membrane associated ring-CH-type finger 11
 10384
 0.3
chr17_26687116_26687267 0.90 Atp6v0e
 ATPase, H+ transporting, lysosomal V0 subunit E
 10779
 0.14
chr5_145982849_145983558 0.90 Cyp3a25
 cytochrome P450, family 3, subfamily a, polypeptide 25
 8440
 0.13
chr5_137481993_137482153 0.89 Epo
 erythropoietin
 3743
 0.1
chr7_16229973_16230150 0.86 Gm45409
 predicted gene 45409
 1161
 0.3
chr7_80464871_80465056 0.84 Blm
 Bloom syndrome, RecQ like helicase
 1086
 0.43
chr14_28283569_28283764 0.84 Gm20242
 predicted gene, 20242
 132331
 0.05
chr6_124666813_124667013 0.83 Lpcat3
 lysophosphatidylcholine acyltransferase 3
 3698
 0.1
chr18_46335696_46335862 0.83 4930415P13Rik
 RIKEN cDNA 4930415P13 gene
 4650
 0.16
chr4_44051303_44051454 0.80 Gne
 glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
 3919
 0.17
chr10_79887085_79887245 0.80 Elane
 elastase, neutrophil expressed
 918
 0.23
chr12_72763283_72763641 0.79 Ppm1a
 protein phosphatase 1A, magnesium dependent, alpha isoform
 2147
 0.31
chr3_95694014_95694171 0.79 Adamtsl4
 ADAMTS-like 4
 6175
 0.11
chr10_126691394_126691560 0.78 Mir378d
 microRNA 378d
 18914
 0.15
chr12_71875530_71876050 0.78 Daam1
 dishevelled associated activator of morphogenesis 1
 13940
 0.21
chr10_94810057_94810242 0.78 Gm24186
 predicted gene, 24186
 11506
 0.16
chr1_191821111_191821273 0.77 Nek2
 NIMA (never in mitosis gene a)-related expressed kinase 2
 252
 0.8
chr13_55103446_55103605 0.77 Zfp346
 zinc finger protein 346
 1786
 0.23
chr13_93622998_93623302 0.76 Gm15622
 predicted gene 15622
 2232
 0.26
chr15_98915891_98916274 0.76 Lmbr1l
 limb region 1 like
 130
 0.89
chr4_32160991_32161147 0.76 Gm11928
 predicted gene 11928
 11283
 0.21
chr5_16317582_16317767 0.75 Cacna2d1
 calcium channel, voltage-dependent, alpha2/delta subunit 1
 8311
 0.25
chr11_31933098_31933283 0.74 4930524B15Rik
 RIKEN cDNA 4930524B15 gene
 32402
 0.16
chr2_29483450_29483627 0.73 Mir133c
 microRNA 133c
 8244
 0.15
chr12_35739125_35739291 0.73 Gm48264
 predicted gene, 48264
 7021
 0.18
chr3_104214062_104214367 0.73 Magi3
 membrane associated guanylate kinase, WW and PDZ domain containing 3
 5889
 0.12
chr14_55899299_55899513 0.72 Sdr39u1
 short chain dehydrogenase/reductase family 39U, member 1
 449
 0.66
chr8_117337291_117337451 0.70 Cmip
 c-Maf inducing protein
 11799
 0.25
chr6_85864689_85864938 0.70 Nat8f2
 N-acetyltransferase 8 (GCN5-related) family member 2
 4345
 0.1
chr8_11148911_11149083 0.70 Gm44717
 predicted gene 44717
 249
 0.91
chr17_29487122_29487273 0.68 Pim1
 proviral integration site 1
 3556
 0.13
chr5_43156906_43157079 0.68 Gm42552
 predicted gene 42552
 8665
 0.21
chr1_131970433_131970601 0.68 Slc45a3
 solute carrier family 45, member 3
 92
 0.95
chr17_73072435_73072612 0.67 Lclat1
 lysocardiolipin acyltransferase 1
 35462
 0.16
chr4_141287858_141288020 0.67 Gm13056
 predicted gene 13056
 9500
 0.1
chr14_36971294_36971453 0.67 Ccser2
 coiled-coil serine rich 2
 2596
 0.29
chr3_131489084_131489522 0.66 Sgms2
 sphingomyelin synthase 2
 1176
 0.58
chr5_88953989_88954155 0.65 Slc4a4
 solute carrier family 4 (anion exchanger), member 4
 19500
 0.24
chr11_108254783_108254943 0.64 Gm11655
 predicted gene 11655
 73013
 0.09
chr2_84762961_84763125 0.64 Serping1
 serine (or cysteine) peptidase inhibitor, clade G, member 1
 12085
 0.08
chr15_47749931_47750085 0.63 Gm16300
 predicted gene 16300
 46181
 0.17
chr7_68280697_68280888 0.61 Gm16157
 predicted gene 16157
 4198
 0.16
chr11_83409286_83409449 0.61 Rasl10b
 RAS-like, family 10, member B
 230
 0.88
chr9_15442312_15442468 0.61 Gm48634
 predicted gene, 48634
 1919
 0.24
chr18_76051312_76051463 0.60 Zbtb7c
 zinc finger and BTB domain containing 7C
 8071
 0.22
chr10_77109671_77109843 0.60 Col18a1
 collagen, type XVIII, alpha 1
 3948
 0.21
chr15_8968437_8968609 0.60 Ranbp3l
 RAN binding protein 3-like
 97
 0.97
chr7_112121062_112121238 0.59 Usp47
 ubiquitin specific peptidase 47
 30444
 0.19
chr11_86989298_86989461 0.59 Ypel2
 yippee like 2
 4328
 0.19
chr6_72212736_72212914 0.59 Atoh8
 atonal bHLH transcription factor 8
 21712
 0.14
chr17_24478264_24478594 0.59 Mlst8
 MTOR associated protein, LST8 homolog (S. cerevisiae)
 49
 0.92
chr8_69063559_69063737 0.59 Slc18a1
 solute carrier family 18 (vesicular monoamine), member 1
 11860
 0.15
chr2_38925242_38925421 0.59 Nr6a1
 nuclear receptor subfamily 6, group A, member 1
 886
 0.43
chr11_69842335_69842486 0.58 Tmem256
 transmembrane protein 256
 3772
 0.07
chr4_133338574_133338734 0.58 Wdtc1
 WD and tetratricopeptide repeats 1
 617
 0.65
chr9_70248725_70249019 0.58 Myo1e
 myosin IE
 41504
 0.15
chr8_33904851_33905143 0.57 Rbpms
 RNA binding protein gene with multiple splicing
 13233
 0.17
chr7_101465911_101466071 0.57 Pde2a
 phosphodiesterase 2A, cGMP-stimulated
 5047
 0.16
chr16_24154494_24154889 0.57 Gm32126
 predicted gene, 32126
 13870
 0.2
chr2_25266466_25266742 0.57 Tprn
 taperin
 960
 0.23
chr2_103811926_103812077 0.56 Gm13878
 predicted gene 13878
 384
 0.68
chr10_63226846_63227134 0.56 Herc4
 hect domain and RLD 4
 16820
 0.11
chr11_95038769_95038930 0.56 Pdk2
 pyruvate dehydrogenase kinase, isoenzyme 2
 1709
 0.23
chr9_83866290_83866453 0.55 Ttk
 Ttk protein kinase
 31605
 0.14
chr6_129175697_129175889 0.55 Gm26160
 predicted gene, 26160
 973
 0.41
chr2_113537620_113538205 0.55 Gm13964
 predicted gene 13964
 33878
 0.16
chr4_130112167_130112332 0.55 Pef1
 penta-EF hand domain containing 1
 4693
 0.16
chr11_106502645_106502807 0.54 Gm22711
 predicted gene, 22711
 1481
 0.29
chr5_134279549_134279704 0.54 Gtf2i
 general transcription factor II I
 239
 0.89
chr6_95819185_95819380 0.54 Suclg2
 succinate-Coenzyme A ligase, GDP-forming, beta subunit
 100482
 0.08
chr9_35136038_35136227 0.54 Gm24262
 predicted gene, 24262
 8504
 0.12
chr18_67958643_67958805 0.54 Ldlrad4
 low density lipoprotein receptor class A domain containing 4
 25467
 0.19
chrX_155337365_155337828 0.53 Prdx4
 peroxiredoxin 4
 871
 0.59
chr5_121665076_121665253 0.52 Brap
 BRCA1 associated protein
 1362
 0.3
chr14_20638160_20638341 0.52 2810402E24Rik
 RIKEN cDNA 2810402E24 gene
 2759
 0.13
chr4_119259446_119259606 0.51 Gm12927
 predicted gene 12927
 2551
 0.13
chr8_121562702_121562861 0.51 Fbxo31
 F-box protein 31
 2818
 0.16
chr5_113735107_113735259 0.51 Ficd
 FIC domain containing
 620
 0.6
chr11_120726590_120726778 0.51 Dcxr
 dicarbonyl L-xylulose reductase
 545
 0.48
chr14_122765965_122766143 0.51 Pcca
 propionyl-Coenzyme A carboxylase, alpha polypeptide
 24345
 0.21
chr5_134170407_134170687 0.50 Rcc1l
 reculator of chromosome condensation 1 like
 1172
 0.37
chr4_140636700_140636879 0.50 Arhgef10l
 Rho guanine nucleotide exchange factor (GEF) 10-like
 11961
 0.16
chr2_121968638_121968832 0.49 Ctdspl2
 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2
 347
 0.85
chr15_36904059_36904218 0.49 Gm10384
 predicted gene 10384
 24322
 0.13
chr3_108804290_108804468 0.49 Stxbp3
 syntaxin binding protein 3
 1352
 0.39
chr9_116947417_116947569 0.49 Gm18489
 predicted gene, 18489
 111665
 0.07
chr17_20287010_20287161 0.49 Vmn2r106
 vomeronasal 2, receptor 106
 1532
 0.35
chr10_121455166_121455317 0.48 Rassf3
 Ras association (RalGDS/AF-6) domain family member 3
 6972
 0.13
chr15_64273225_64273401 0.47 Asap1
 ArfGAP with SH3 domain, ankyrin repeat and PH domain1
 38376
 0.15
chr2_31530318_31530475 0.47 Ass1
 argininosuccinate synthetase 1
 11906
 0.15
chr15_36914757_36914955 0.47 Gm41300
 predicted gene, 41300
 16830
 0.15
chr7_141337790_141337972 0.47 Eps8l2
 EPS8-like 2
 999
 0.3
chr16_4757027_4757557 0.46 Hmox2
 heme oxygenase 2
 298
 0.84
chr5_74813446_74813635 0.46 Gm42575
 predicted gene 42575
 63658
 0.09
chr13_28757565_28757740 0.46 Mir6368
 microRNA 6368
 46779
 0.15
chr11_21058339_21058501 0.46 Peli1
 pellino 1
 32871
 0.16
chr11_70745785_70745982 0.46 Gm12320
 predicted gene 12320
 9268
 0.08
chr15_102171688_102171839 0.46 Csad
 cysteine sulfinic acid decarboxylase
 7256
 0.1
chr7_123850432_123850600 0.46 Gm23788
 predicted gene, 23788
 91693
 0.08
chr8_71307755_71307928 0.46 Myo9b
 myosin IXb
 25976
 0.11
chr18_20938375_20938560 0.46 Rnf125
 ring finger protein 125
 6158
 0.22
chr11_75661487_75661650 0.45 Myo1c
 myosin IC
 165
 0.92
chr15_99790865_99791044 0.45 Lima1
 LIM domain and actin binding 1
 6981
 0.09
chr11_105237702_105237861 0.45 Tlk2
 tousled-like kinase 2 (Arabidopsis)
 8977
 0.19
chrX_60831870_60832021 0.45 Gm14660
 predicted gene 14660
 13737
 0.19
chr5_81908094_81908272 0.45 2900064F13Rik
 RIKEN cDNA 2900064F13 gene
 81367
 0.1
chr7_80830498_80830680 0.44 Iqgap1
 IQ motif containing GTPase activating protein 1
 4615
 0.18
chr13_32169128_32169451 0.44 Gmds
 GDP-mannose 4, 6-dehydratase
 57952
 0.13
chr2_12060466_12060629 0.44 Gm13310
 predicted gene 13310
 23445
 0.21
chr17_47888408_47888575 0.43 Foxp4
 forkhead box P4
 58
 0.96
chr11_78698801_78698963 0.43 Nlk
 nemo like kinase
 1509
 0.33
chr11_44173581_44173732 0.43 Gm12154
 predicted gene 12154
 93553
 0.08
chr13_31171886_31172048 0.43 Gm11372
 predicted gene 11372
 27119
 0.19
chr7_134497184_134497335 0.43 D7Ertd443e
 DNA segment, Chr 7, ERATO Doi 443, expressed
 1725
 0.51
chr3_115682777_115683090 0.43 S1pr1
 sphingosine-1-phosphate receptor 1
 32139
 0.17
chr2_80600719_80600876 0.43 Gm13688
 predicted gene 13688
 1936
 0.21
chr4_11147830_11148134 0.42 Gm11830
 predicted gene 11830
 3272
 0.15
chr18_38205562_38205736 0.42 Pcdh1
 protocadherin 1
 1809
 0.24
chr16_21865351_21865519 0.41 Gm26744
 predicted gene, 26744
 19659
 0.11
chr7_110920925_110921090 0.41 Mrvi1
 MRV integration site 1
 2696
 0.25
chr5_149198922_149199082 0.41 Uspl1
 ubiquitin specific peptidase like 1
 7666
 0.09
chr2_151925877_151926031 0.40 Angpt4
 angiopoietin 4
 14744
 0.13
chr2_3770483_3770646 0.39 Fam107b
 family with sequence similarity 107, member B
 144
 0.96
chr17_88509210_88509380 0.39 Ppp1r21
 protein phosphatase 1, regulatory subunit 21
 20823
 0.16
chr18_60769849_60770150 0.39 Rps14
 ribosomal protein S14
 4597
 0.15
chr11_119954339_119954501 0.39 Baiap2
 brain-specific angiogenesis inhibitor 1-associated protein 2
 5601
 0.13
chr9_77927047_77927209 0.38 Elovl5
 ELOVL family member 5, elongation of long chain fatty acids (yeast)
 5196
 0.17
chr11_35783421_35783583 0.38 Mir103-1
 microRNA 103-1
 1106
 0.43
chr1_7104338_7104546 0.38 Pcmtd1
 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1
 15276
 0.15
chr16_23218528_23218719 0.38 St6gal1
 beta galactoside alpha 2,6 sialyltransferase 1
 6117
 0.11
chr6_49210657_49210827 0.38 Igf2bp3
 insulin-like growth factor 2 mRNA binding protein 3
 3419
 0.2
chr10_108449802_108449991 0.38 Gm36283
 predicted gene, 36283
 3294
 0.25
chr9_45833631_45833782 0.38 Gm7286
 predicted gene 7286
 3229
 0.12
chr12_80146592_80146753 0.38 2310015A10Rik
 RIKEN cDNA 2310015A10 gene
 13828
 0.12
chr9_44406569_44406995 0.37 Trappc4
 trafficking protein particle complex 4
 260
 0.51
chr3_85786657_85786819 0.37 Fam160a1
 family with sequence similarity 160, member A1
 30553
 0.16
chr5_112344431_112344696 0.37 Hps4
 HPS4, biogenesis of lysosomal organelles complex 3 subunit 2
 1463
 0.2
chr2_75999812_75999973 0.37 Pde11a
 phosphodiesterase 11A
 6151
 0.18
chr10_14035731_14035911 0.37 Hivep2
 human immunodeficiency virus type I enhancer binding protein 2
 68797
 0.09
chr5_107272625_107272804 0.37 Gm42900
 predicted gene 42900
 16210
 0.12
chr17_84026540_84026710 0.36 Gm35551
 predicted gene, 35551
 606
 0.62
chr7_5021714_5021881 0.36 Zfp865
 zinc finger protein 865
 1210
 0.17
chr18_24652431_24652590 0.36 Mocos
 molybdenum cofactor sulfurase
 1181
 0.43
chr12_100191588_100191746 0.35 Gm10433
 predicted gene 10433
 2894
 0.18
chr12_21136203_21136399 0.35 Asap2
 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
 24347
 0.18
chr3_68593185_68593343 0.35 Schip1
 schwannomin interacting protein 1
 2911
 0.3
chr12_87408323_87408513 0.35 Gm8557
 predicted gene 8557
 12093
 0.07
chr14_63246048_63246212 0.35 Gata4
 GATA binding protein 4
 859
 0.59
chr8_111775967_111776118 0.35 Bcar1
 breast cancer anti-estrogen resistance 1
 32233
 0.14
chr1_36571715_36571905 0.35 D430040D24Rik
 RIKEN cDNA D430040D24 gene
 13451
 0.09
chrX_99138009_99138168 0.35 Efnb1
 ephrin B1
 43
 0.98
chr16_23592594_23592752 0.35 Rtp4
 receptor transporter protein 4
 9069
 0.21
chr6_124528028_124528336 0.35 Gm16567
 predicted gene 16567
 2729
 0.14
chr4_137471059_137471217 0.35 Hspg2
 perlecan (heparan sulfate proteoglycan 2)
 2335
 0.21
chr9_63534222_63534551 0.34 Gm16759
 predicted gene, 16759
 3034
 0.28
chr4_134488308_134488479 0.34 Gm13250
 predicted gene 13250
 4829
 0.11
chr6_116415099_116415265 0.34 Alox5
 arachidonate 5-lipoxygenase
 1162
 0.37
chr5_111336024_111336199 0.34 Pitpnb
 phosphatidylinositol transfer protein, beta
 5304
 0.19
chr15_36585261_36585431 0.34 Gm44310
 predicted gene, 44310
 1802
 0.26
chr12_79689447_79689598 0.34 9430078K24Rik
 RIKEN cDNA 9430078K24 gene
 235211
 0.02
chr5_147880674_147880894 0.33 Slc46a3
 solute carrier family 46, member 3
 915
 0.53
chr10_18074695_18074946 0.33 Reps1
 RalBP1 associated Eps domain containing protein
 16648
 0.19
chr7_98141341_98141502 0.33 Omp
 olfactory marker protein
 4081
 0.18
chr7_127811270_127811556 0.33 Stx1b
 syntaxin 1B
 489
 0.54
chr1_157526751_157526916 0.33 Sec16b
 SEC16 homolog B (S. cerevisiae)
 686
 0.65
chr5_107834436_107834622 0.33 Evi5
 ecotropic viral integration site 5
 2951
 0.15
chr13_98944666_98945270 0.32 Gm35215
 predicted gene, 35215
 948
 0.45

Histogram of CRE-TSS distances for CREs targeted by :

Histogram of

Rank distribution of CRE target scores:

Histogram of target CRE score.

Distribution of target CREs across different genomic regions:

Weighted Piechart of Weighted Piechart of Weighted Piechart of

Network of associatons between targets according to the STRING database.

First level regulatory network of Rarb

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.4 GO:2000302 positive regulation of synaptic vesicle exocytosis(GO:2000302)
0.2 0.6 GO:0015770 disaccharide transport(GO:0015766) sucrose transport(GO:0015770) oligosaccharide transport(GO:0015772)
0.2 0.6 GO:0030997 regulation of centriole-centriole cohesion(GO:0030997)
0.1 0.6 GO:0097039 protein linear polyubiquitination(GO:0097039)
0.1 0.4 GO:1900748 positive regulation of vascular endothelial growth factor signaling pathway(GO:1900748)
0.1 0.3 GO:0021699 cerebellar cortex maturation(GO:0021699)
0.1 0.4 GO:0006787 porphyrin-containing compound catabolic process(GO:0006787) tetrapyrrole catabolic process(GO:0033015)
0.1 0.4 GO:0045950 negative regulation of mitotic recombination(GO:0045950)
0.1 0.4 GO:0060480 lung goblet cell differentiation(GO:0060480)
0.1 0.3 GO:0035054 embryonic heart tube anterior/posterior pattern specification(GO:0035054)
0.1 0.3 GO:2000255 negative regulation of male germ cell proliferation(GO:2000255)
0.1 0.2 GO:0042732 D-xylose metabolic process(GO:0042732)
0.1 0.4 GO:0006686 sphingomyelin biosynthetic process(GO:0006686)
0.1 0.3 GO:0010273 detoxification of copper ion(GO:0010273) stress response to copper ion(GO:1990169)
0.1 1.2 GO:0046827 positive regulation of protein export from nucleus(GO:0046827)
0.1 0.2 GO:0048207 vesicle targeting, rough ER to cis-Golgi(GO:0048207) COPII vesicle coating(GO:0048208)
0.1 0.2 GO:0048320 axial mesoderm formation(GO:0048320)
0.1 0.4 GO:0010886 positive regulation of cholesterol storage(GO:0010886)
0.1 0.2 GO:1901843 positive regulation of high voltage-gated calcium channel activity(GO:1901843)
0.1 0.2 GO:0061669 spontaneous neurotransmitter secretion(GO:0061669) spontaneous synaptic transmission(GO:0098814)
0.1 0.2 GO:2000670 positive regulation of dendritic cell apoptotic process(GO:2000670)
0.1 0.2 GO:0045079 negative regulation of chemokine biosynthetic process(GO:0045079)
0.0 0.3 GO:0045213 neurotransmitter receptor metabolic process(GO:0045213)
0.0 0.2 GO:0072675 osteoclast fusion(GO:0072675)
0.0 0.1 GO:0010735 positive regulation of transcription via serum response element binding(GO:0010735)
0.0 0.1 GO:0002540 leukotriene production involved in inflammatory response(GO:0002540)
0.0 0.1 GO:0070340 detection of bacterial lipopeptide(GO:0070340)
0.0 0.1 GO:0050717 positive regulation of interleukin-1 alpha secretion(GO:0050717)
0.0 0.1 GO:1902564 negative regulation of neutrophil activation(GO:1902564)
0.0 0.4 GO:0051292 nuclear pore complex assembly(GO:0051292)
0.0 0.2 GO:0071712 ER-associated misfolded protein catabolic process(GO:0071712)
0.0 0.2 GO:0072310 glomerular visceral epithelial cell development(GO:0072015) glomerular epithelial cell development(GO:0072310)
0.0 0.1 GO:0000101 sulfur amino acid transport(GO:0000101)
0.0 0.3 GO:0072378 blood coagulation, fibrin clot formation(GO:0072378)
0.0 0.1 GO:1903223 positive regulation of oxidative stress-induced neuron death(GO:1903223)
0.0 0.1 GO:2000065 negative regulation of aldosterone metabolic process(GO:0032345) negative regulation of aldosterone biosynthetic process(GO:0032348) negative regulation of cortisol biosynthetic process(GO:2000065)
0.0 0.1 GO:0006651 diacylglycerol biosynthetic process(GO:0006651)
0.0 0.2 GO:0090557 establishment of endothelial intestinal barrier(GO:0090557)
0.0 0.1 GO:0030208 dermatan sulfate biosynthetic process(GO:0030208)
0.0 0.5 GO:0014733 regulation of skeletal muscle adaptation(GO:0014733)
0.0 0.1 GO:0070537 histone H2A K63-linked deubiquitination(GO:0070537)
0.0 0.1 GO:0010510 regulation of acetyl-CoA biosynthetic process from pyruvate(GO:0010510)
0.0 0.2 GO:0006777 Mo-molybdopterin cofactor biosynthetic process(GO:0006777) Mo-molybdopterin cofactor metabolic process(GO:0019720) molybdopterin cofactor biosynthetic process(GO:0032324) molybdopterin cofactor metabolic process(GO:0043545) prosthetic group metabolic process(GO:0051189)
0.0 0.1 GO:0009093 cysteine catabolic process(GO:0009093) L-cysteine catabolic process(GO:0019448) L-cysteine metabolic process(GO:0046439)
0.0 0.1 GO:0048619 embryonic hindgut morphogenesis(GO:0048619)
0.0 0.1 GO:0002378 immunoglobulin biosynthetic process(GO:0002378)
0.0 0.0 GO:2000645 negative regulation of receptor catabolic process(GO:2000645)
0.0 0.0 GO:0097029 mature conventional dendritic cell differentiation(GO:0097029)
0.0 0.1 GO:1903377 negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903377)
0.0 0.4 GO:0045717 negative regulation of fatty acid biosynthetic process(GO:0045717)
0.0 0.1 GO:1900126 negative regulation of hyaluronan biosynthetic process(GO:1900126)
0.0 0.1 GO:0006015 5-phosphoribose 1-diphosphate biosynthetic process(GO:0006015) 5-phosphoribose 1-diphosphate metabolic process(GO:0046391)
0.0 0.1 GO:0097212 lysosomal membrane organization(GO:0097212)
0.0 0.1 GO:0007354 zygotic determination of anterior/posterior axis, embryo(GO:0007354)
0.0 0.1 GO:0033159 negative regulation of protein import into nucleus, translocation(GO:0033159)
0.0 0.1 GO:1902219 intrinsic apoptotic signaling pathway in response to osmotic stress(GO:0008627) regulation of intrinsic apoptotic signaling pathway in response to osmotic stress(GO:1902218) negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress(GO:1902219)
0.0 0.1 GO:0097503 sialylation(GO:0097503)
0.0 0.1 GO:1900029 positive regulation of ruffle assembly(GO:1900029)
0.0 0.2 GO:0006689 ganglioside catabolic process(GO:0006689)
0.0 0.1 GO:0060005 vestibular reflex(GO:0060005)
0.0 0.1 GO:0061110 dense core granule biogenesis(GO:0061110)
0.0 0.2 GO:0071267 amino acid salvage(GO:0043102) L-methionine biosynthetic process(GO:0071265) L-methionine salvage(GO:0071267)
0.0 0.1 GO:2000359 regulation of binding of sperm to zona pellucida(GO:2000359)
0.0 0.1 GO:0036438 maintenance of lens transparency(GO:0036438)
0.0 0.1 GO:0019344 cysteine biosynthetic process(GO:0019344)
0.0 0.1 GO:0010991 negative regulation of SMAD protein complex assembly(GO:0010991)
0.0 0.1 GO:1900169 regulation of glucocorticoid mediated signaling pathway(GO:1900169)
0.0 0.1 GO:0010046 response to mycotoxin(GO:0010046)
0.0 0.1 GO:0051581 negative regulation of neurotransmitter uptake(GO:0051581) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612)
0.0 0.0 GO:0061341 non-canonical Wnt signaling pathway involved in heart development(GO:0061341) planar cell polarity pathway involved in heart morphogenesis(GO:0061346)
0.0 0.1 GO:0006398 mRNA 3'-end processing by stem-loop binding and cleavage(GO:0006398)
0.0 0.2 GO:0070561 vitamin D receptor signaling pathway(GO:0070561)
0.0 0.2 GO:0035999 tetrahydrofolate interconversion(GO:0035999)
0.0 0.1 GO:0060744 thelarche(GO:0042695) mammary gland branching involved in thelarche(GO:0060744)
0.0 0.1 GO:0051771 negative regulation of nitric-oxide synthase biosynthetic process(GO:0051771)
0.0 0.1 GO:0072553 terminal button organization(GO:0072553)
0.0 0.1 GO:0019805 quinolinate biosynthetic process(GO:0019805)
0.0 0.2 GO:0042904 9-cis-retinoic acid biosynthetic process(GO:0042904) 9-cis-retinoic acid metabolic process(GO:0042905)
0.0 0.1 GO:0035590 purinergic nucleotide receptor signaling pathway(GO:0035590)
0.0 0.1 GO:0070295 renal water absorption(GO:0070295)
0.0 0.2 GO:0022615 protein to membrane docking(GO:0022615)
0.0 0.1 GO:0034773 histone H4-K20 trimethylation(GO:0034773)
0.0 0.1 GO:0015868 purine ribonucleotide transport(GO:0015868)
0.0 0.2 GO:0019934 cGMP-mediated signaling(GO:0019934)
0.0 0.4 GO:0015701 bicarbonate transport(GO:0015701)
0.0 0.1 GO:0042997 negative regulation of Golgi to plasma membrane protein transport(GO:0042997)
0.0 0.2 GO:1903025 regulation of RNA polymerase II regulatory region sequence-specific DNA binding(GO:1903025)
0.0 0.0 GO:0003347 epicardial cell to mesenchymal cell transition(GO:0003347)
0.0 0.2 GO:0033136 serine phosphorylation of STAT3 protein(GO:0033136)
0.0 0.1 GO:0044339 canonical Wnt signaling pathway involved in osteoblast differentiation(GO:0044339)
0.0 0.0 GO:1900623 regulation of monocyte aggregation(GO:1900623) positive regulation of monocyte aggregation(GO:1900625)
0.0 0.0 GO:0070640 vitamin D3 metabolic process(GO:0070640)
0.0 0.1 GO:0030050 vesicle transport along actin filament(GO:0030050)
0.0 0.1 GO:1902093 positive regulation of sperm motility(GO:1902093)
0.0 0.0 GO:2000338 chemokine (C-X-C motif) ligand 1 production(GO:0072566) regulation of chemokine (C-X-C motif) ligand 1 production(GO:2000338)
0.0 0.1 GO:0034141 positive regulation of toll-like receptor 3 signaling pathway(GO:0034141)
0.0 0.1 GO:2000623 regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000622) negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000623)
0.0 0.1 GO:0000710 meiotic mismatch repair(GO:0000710)
0.0 0.1 GO:2000766 negative regulation of cytoplasmic translation(GO:2000766)
0.0 0.1 GO:0002430 complement receptor mediated signaling pathway(GO:0002430)
0.0 0.1 GO:0030242 pexophagy(GO:0030242)
0.0 0.1 GO:0030576 Cajal body organization(GO:0030576)
0.0 0.2 GO:0001886 endothelial cell morphogenesis(GO:0001886)
0.0 0.1 GO:0044314 protein K27-linked ubiquitination(GO:0044314)
0.0 0.1 GO:0019367 fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.0 0.2 GO:0007095 mitotic G2 DNA damage checkpoint(GO:0007095)
0.0 0.1 GO:0002091 negative regulation of receptor internalization(GO:0002091)
0.0 0.1 GO:0035520 monoubiquitinated protein deubiquitination(GO:0035520)
0.0 0.1 GO:0036289 peptidyl-serine autophosphorylation(GO:0036289)
0.0 0.0 GO:1901874 regulation of post-translational protein modification(GO:1901873) negative regulation of post-translational protein modification(GO:1901874)
0.0 0.0 GO:1900825 regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900825)
0.0 0.1 GO:0003241 growth involved in heart morphogenesis(GO:0003241)
0.0 0.0 GO:0015755 fructose transport(GO:0015755)
0.0 0.5 GO:0032008 positive regulation of TOR signaling(GO:0032008)
0.0 0.1 GO:0046598 positive regulation of viral entry into host cell(GO:0046598)
0.0 0.0 GO:0046655 folic acid metabolic process(GO:0046655)
0.0 0.4 GO:0031295 T cell costimulation(GO:0031295)
0.0 0.1 GO:1900086 regulation of peptidyl-tyrosine autophosphorylation(GO:1900084) positive regulation of peptidyl-tyrosine autophosphorylation(GO:1900086)
0.0 0.1 GO:0033689 negative regulation of osteoblast proliferation(GO:0033689)
0.0 0.0 GO:0097680 double-strand break repair via classical nonhomologous end joining(GO:0097680)
0.0 0.0 GO:0051365 cellular response to potassium ion starvation(GO:0051365)
0.0 0.1 GO:0001867 complement activation, lectin pathway(GO:0001867)
0.0 0.0 GO:0090038 negative regulation of protein kinase C signaling(GO:0090038)
0.0 0.1 GO:0006054 N-acetylneuraminate metabolic process(GO:0006054)
0.0 0.1 GO:0003383 apical constriction(GO:0003383)
0.0 0.0 GO:0060178 regulation of exocyst localization(GO:0060178)
0.0 0.1 GO:1904707 positive regulation of vascular smooth muscle cell proliferation(GO:1904707)
0.0 0.1 GO:0033623 regulation of integrin activation(GO:0033623)
0.0 0.1 GO:0070986 left/right axis specification(GO:0070986)
0.0 0.1 GO:0033622 integrin activation(GO:0033622)
0.0 0.0 GO:0003431 growth plate cartilage chondrocyte development(GO:0003431)
0.0 0.3 GO:0030970 retrograde protein transport, ER to cytosol(GO:0030970)
0.0 0.0 GO:0070375 ERK5 cascade(GO:0070375)
0.0 0.0 GO:0006435 threonyl-tRNA aminoacylation(GO:0006435)
0.0 0.1 GO:0097062 dendritic spine maintenance(GO:0097062)
0.0 0.1 GO:0051764 actin crosslink formation(GO:0051764)
0.0 0.1 GO:0072321 chaperone-mediated protein transport(GO:0072321)
0.0 0.2 GO:0010640 regulation of platelet-derived growth factor receptor signaling pathway(GO:0010640)
0.0 0.0 GO:0010748 negative regulation of plasma membrane long-chain fatty acid transport(GO:0010748)
0.0 0.1 GO:0046618 drug export(GO:0046618)
0.0 0.0 GO:0038108 negative regulation of appetite by leptin-mediated signaling pathway(GO:0038108)
0.0 0.0 GO:0048014 Tie signaling pathway(GO:0048014)
0.0 0.1 GO:0015808 L-alanine transport(GO:0015808)
0.0 0.0 GO:0018364 peptidyl-glutamine methylation(GO:0018364)
0.0 0.1 GO:1904996 positive regulation of leukocyte adhesion to vascular endothelial cell(GO:1904996)
0.0 0.0 GO:2000721 positive regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation(GO:2000721)
0.0 0.1 GO:0035385 Roundabout signaling pathway(GO:0035385)
0.0 0.0 GO:0033861 negative regulation of NAD(P)H oxidase activity(GO:0033861)
0.0 0.1 GO:0051005 negative regulation of lipoprotein lipase activity(GO:0051005)
0.0 0.5 GO:0001990 regulation of systemic arterial blood pressure by hormone(GO:0001990)
0.0 0.0 GO:0009804 coumarin metabolic process(GO:0009804)
0.0 0.0 GO:0030423 targeting of mRNA for destruction involved in RNA interference(GO:0030423)
0.0 0.0 GO:0090245 axis elongation involved in somitogenesis(GO:0090245)
0.0 0.1 GO:0006857 oligopeptide transport(GO:0006857)
0.0 0.0 GO:1903964 monounsaturated fatty acid metabolic process(GO:1903964) monounsaturated fatty acid biosynthetic process(GO:1903966)
0.0 0.0 GO:0032876 negative regulation of DNA endoreduplication(GO:0032876)
0.0 0.1 GO:1902018 negative regulation of cilium assembly(GO:1902018)
0.0 0.0 GO:0071926 cannabinoid signaling pathway(GO:0038171) endocannabinoid signaling pathway(GO:0071926)
0.0 0.0 GO:1901078 negative regulation of relaxation of muscle(GO:1901078)
0.0 0.1 GO:0018101 protein citrullination(GO:0018101)
0.0 0.1 GO:0000712 resolution of meiotic recombination intermediates(GO:0000712)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0030313 cell outer membrane(GO:0009279) cell envelope(GO:0030313) external encapsulating structure part(GO:0044462)
0.1 0.4 GO:0016461 unconventional myosin complex(GO:0016461)
0.1 0.6 GO:0031931 TORC1 complex(GO:0031931)
0.0 0.3 GO:0030008 TRAPP complex(GO:0030008)
0.0 0.1 GO:0034666 integrin alpha2-beta1 complex(GO:0034666)
0.0 0.1 GO:0035355 Toll-like receptor 2-Toll-like receptor 6 protein complex(GO:0035355)
0.0 0.2 GO:0070820 tertiary granule(GO:0070820)
0.0 0.2 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.0 0.1 GO:1990604 IRE1-TRAF2-ASK1 complex(GO:1990604)
0.0 0.3 GO:0034362 low-density lipoprotein particle(GO:0034362)
0.0 0.2 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.0 0.2 GO:0005577 fibrinogen complex(GO:0005577)
0.0 0.4 GO:0000800 lateral element(GO:0000800)
0.0 0.0 GO:0032127 dense core granule membrane(GO:0032127)
0.0 1.4 GO:0031594 neuromuscular junction(GO:0031594)
0.0 0.1 GO:0070531 BRCA1-A complex(GO:0070531)
0.0 0.2 GO:0005641 nuclear envelope lumen(GO:0005641)
0.0 0.1 GO:0031298 replication fork protection complex(GO:0031298)
0.0 0.2 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.0 0.2 GO:0036513 Derlin-1 retrotranslocation complex(GO:0036513)
0.0 0.1 GO:0009331 glycerol-3-phosphate dehydrogenase complex(GO:0009331)
0.0 0.1 GO:0042827 platelet dense granule(GO:0042827)
0.0 0.1 GO:0034673 inhibin-betaglycan-ActRII complex(GO:0034673)
0.0 0.1 GO:0030062 mitochondrial tricarboxylic acid cycle enzyme complex(GO:0030062)
0.0 0.0 GO:0097057 TRAF2-GSTP1 complex(GO:0097057)
0.0 0.1 GO:0030130 clathrin coat of trans-Golgi network vesicle(GO:0030130)
0.0 0.1 GO:0042719 mitochondrial intermembrane space protein transporter complex(GO:0042719)
0.0 0.1 GO:0033179 proton-transporting V-type ATPase, V0 domain(GO:0033179)
0.0 0.1 GO:0042382 paraspeckles(GO:0042382)
0.0 0.0 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.0 0.1 GO:0005796 Golgi lumen(GO:0005796)
0.0 0.1 GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)
0.0 0.3 GO:0030992 intraciliary transport particle B(GO:0030992)
0.0 0.0 GO:0035838 growing cell tip(GO:0035838)
0.0 0.1 GO:0033269 internode region of axon(GO:0033269)
0.0 0.1 GO:0097136 Bcl-2 family protein complex(GO:0097136)
0.0 0.0 GO:0071001 U4/U6 snRNP(GO:0071001)
0.0 0.0 GO:1990393 3M complex(GO:1990393)
0.0 0.0 GO:0071438 invadopodium membrane(GO:0071438)
0.0 0.1 GO:0033180 proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.0 0.2 GO:0005605 basal lamina(GO:0005605)
0.0 0.1 GO:0070419 nonhomologous end joining complex(GO:0070419)
0.0 0.0 GO:0012510 trans-Golgi network transport vesicle membrane(GO:0012510)
0.0 0.1 GO:0032591 dendritic spine membrane(GO:0032591)
0.0 0.2 GO:0045334 clathrin-coated endocytic vesicle(GO:0045334)
0.0 0.2 GO:0005849 mRNA cleavage factor complex(GO:0005849)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.6 GO:0015157 sucrose:proton symporter activity(GO:0008506) sucrose transmembrane transporter activity(GO:0008515) disaccharide transmembrane transporter activity(GO:0015154) oligosaccharide transmembrane transporter activity(GO:0015157)
0.2 1.4 GO:0019992 diacylglycerol binding(GO:0019992)
0.1 0.4 GO:0051880 G-quadruplex DNA binding(GO:0051880)
0.1 0.2 GO:0005128 erythropoietin receptor binding(GO:0005128)
0.1 0.3 GO:0036435 K48-linked polyubiquitin binding(GO:0036435)
0.1 0.3 GO:0033192 calmodulin-dependent protein phosphatase activity(GO:0033192)
0.1 0.3 GO:0008390 testosterone 16-alpha-hydroxylase activity(GO:0008390)
0.1 0.3 GO:0017034 Rap guanyl-nucleotide exchange factor activity(GO:0017034)
0.1 0.2 GO:0016882 cyclo-ligase activity(GO:0016882)
0.1 0.2 GO:0035663 Toll-like receptor 2 binding(GO:0035663)
0.1 0.2 GO:0008898 S-adenosylmethionine-homocysteine S-methyltransferase activity(GO:0008898)
0.0 0.1 GO:0097200 cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:0097200)
0.0 0.3 GO:0051920 peroxiredoxin activity(GO:0051920)
0.0 0.1 GO:0050692 DBD domain binding(GO:0050692)
0.0 0.2 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.0 0.1 GO:0017150 tRNA dihydrouridine synthase activity(GO:0017150)
0.0 0.2 GO:0051525 NFAT protein binding(GO:0051525)
0.0 0.2 GO:0004563 beta-N-acetylhexosaminidase activity(GO:0004563)
0.0 0.2 GO:0016176 superoxide-generating NADPH oxidase activator activity(GO:0016176)
0.0 0.1 GO:0005148 prolactin receptor binding(GO:0005148)
0.0 0.0 GO:0035276 ethanol binding(GO:0035276)
0.0 0.1 GO:0004942 anaphylatoxin receptor activity(GO:0004942)
0.0 0.1 GO:0004740 pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740)
0.0 0.2 GO:1990381 ubiquitin-specific protease binding(GO:1990381)
0.0 0.7 GO:0070412 R-SMAD binding(GO:0070412)
0.0 0.2 GO:0004022 alcohol dehydrogenase (NAD) activity(GO:0004022)
0.0 0.2 GO:0035381 extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381)
0.0 0.2 GO:0030151 molybdenum ion binding(GO:0030151)
0.0 0.1 GO:0071987 WD40-repeat domain binding(GO:0071987)
0.0 0.1 GO:0015222 serotonin transmembrane transporter activity(GO:0015222)
0.0 0.4 GO:0015106 bicarbonate transmembrane transporter activity(GO:0015106)
0.0 0.1 GO:0008310 single-stranded DNA 3'-5' exodeoxyribonuclease activity(GO:0008310)
0.0 0.6 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.0 0.1 GO:0008532 N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity(GO:0008532)
0.0 0.2 GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives(GO:0016857)
0.0 0.1 GO:0043423 3-phosphoinositide-dependent protein kinase binding(GO:0043423)
0.0 0.6 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.0 0.4 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.0 0.1 GO:0030911 TPR domain binding(GO:0030911)
0.0 0.1 GO:0000099 sulfur amino acid transmembrane transporter activity(GO:0000099)
0.0 0.1 GO:0005280 hydrogen:amino acid symporter activity(GO:0005280)
0.0 0.1 GO:0031849 olfactory receptor binding(GO:0031849)
0.0 0.6 GO:0051019 mitogen-activated protein kinase binding(GO:0051019)
0.0 0.5 GO:0052830 phosphohistidine phosphatase activity(GO:0008969) inositol-1,3,4-trisphosphate 4-phosphatase activity(GO:0017161) NADP phosphatase activity(GO:0019178) 5-amino-6-(5-phosphoribitylamino)uracil phosphatase activity(GO:0043726) phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity(GO:0043813) inositol-1,3,4,5,6-pentakisphosphate 1-phosphatase activity(GO:0052825) inositol-3,4-bisphosphate 4-phosphatase activity(GO:0052828) inositol-1,3,4-trisphosphate 1-phosphatase activity(GO:0052829) inositol-1,3,4,6-tetrakisphosphate 6-phosphatase activity(GO:0052830) inositol-1,3,4,6-tetrakisphosphate 1-phosphatase activity(GO:0052831) phosphatidylinositol-1,4,5-trisphosphate 5-phosphatase activity(GO:0052867) IDP phosphatase activity(GO:1990003)
0.0 0.1 GO:0002060 purine nucleobase binding(GO:0002060)
0.0 0.1 GO:0052760 4-methyloctanoyl-CoA dehydrogenase activity(GO:0034580) naphthyl-2-methyl-succinyl-CoA dehydrogenase activity(GO:0034845) 2-methylhexanoyl-CoA dehydrogenase activity(GO:0034916) propionyl-CoA dehydrogenase activity(GO:0043820) thiol-driven fumarate reductase activity(GO:0043830) coenzyme F420-dependent 2,4,6-trinitrophenol reductase activity(GO:0052758) coenzyme F420-dependent 2,4,6-trinitrophenol hydride reductase activity(GO:0052759) coenzyme F420-dependent 2,4-dinitrophenol reductase activity(GO:0052760)
0.0 0.2 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.0 0.1 GO:0004367 glycerol-3-phosphate dehydrogenase [NAD+] activity(GO:0004367)
0.0 0.1 GO:0050816 phosphothreonine binding(GO:0050816)
0.0 0.1 GO:0051371 muscle alpha-actinin binding(GO:0051371)
0.0 0.1 GO:0015288 porin activity(GO:0015288)
0.0 0.1 GO:0004719 protein-L-isoaspartate (D-aspartate) O-methyltransferase activity(GO:0004719)
0.0 0.1 GO:0032142 single guanine insertion binding(GO:0032142)
0.0 0.2 GO:0043024 ribosomal small subunit binding(GO:0043024)
0.0 0.1 GO:0051434 BH3 domain binding(GO:0051434)
0.0 0.4 GO:0044105 C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity(GO:0000252) mevaldate reductase activity(GO:0004495) gluconate dehydrogenase activity(GO:0008875) epoxide dehydrogenase activity(GO:0018451) 5-exo-hydroxycamphor dehydrogenase activity(GO:0018452) 2-hydroxytetrahydrofuran dehydrogenase activity(GO:0018453) acetoin dehydrogenase activity(GO:0019152) phenylcoumaran benzylic ether reductase activity(GO:0032442) D-xylose:NADP reductase activity(GO:0032866) L-arabinose:NADP reductase activity(GO:0032867) D-arabinitol dehydrogenase, D-ribulose forming (NADP+) activity(GO:0033709) (R)-(-)-1,2,3,4-tetrahydronaphthol dehydrogenase activity(GO:0034831) 3-hydroxymenthone dehydrogenase activity(GO:0034840) very long-chain-3-hydroxyacyl-CoA dehydrogenase activity(GO:0035380) (R)-2-hydroxyisocaproate dehydrogenase activity(GO:0043713) L-arabinose 1-dehydrogenase (NADP+) activity(GO:0044103) L-xylulose reductase (NAD+) activity(GO:0044105) 3-ketoglucose-reductase activity(GO:0048258) D-arabinitol dehydrogenase, D-xylulose forming (NADP+) activity(GO:0052677)
0.0 0.1 GO:0032051 clathrin light chain binding(GO:0032051)
0.0 0.2 GO:0017160 Ral GTPase binding(GO:0017160)
0.0 0.1 GO:0045503 dynein light chain binding(GO:0045503)
0.0 0.1 GO:0051733 ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity(GO:0046404) polydeoxyribonucleotide kinase activity(GO:0051733)
0.0 0.1 GO:0003688 DNA replication origin binding(GO:0003688)
0.0 0.1 GO:0102338 fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)
0.0 0.3 GO:0016780 phosphotransferase activity, for other substituted phosphate groups(GO:0016780)
0.0 0.1 GO:0048495 Roundabout binding(GO:0048495)
0.0 0.1 GO:0016892 endoribonuclease activity, producing 3'-phosphomonoesters(GO:0016892)
0.0 0.0 GO:0031800 type 3 metabotropic glutamate receptor binding(GO:0031800)
0.0 0.1 GO:0003836 beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.0 0.0 GO:0051870 methotrexate binding(GO:0051870)
0.0 0.0 GO:0060230 lipoprotein lipase activator activity(GO:0060230)
0.0 0.1 GO:0004468 lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468)
0.0 0.1 GO:0035184 histone threonine kinase activity(GO:0035184)
0.0 0.2 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0 0.2 GO:0030169 low-density lipoprotein particle binding(GO:0030169)
0.0 0.1 GO:0070097 delta-catenin binding(GO:0070097)
0.0 0.1 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)
0.0 0.1 GO:0047184 1-acylglycerophosphocholine O-acyltransferase activity(GO:0047184)
0.0 0.1 GO:0015198 oligopeptide transporter activity(GO:0015198)
0.0 0.1 GO:0031544 peptidyl-proline 3-dioxygenase activity(GO:0031544)
0.0 0.0 GO:0032405 MutLalpha complex binding(GO:0032405)
0.0 0.1 GO:0015377 cation:chloride symporter activity(GO:0015377)
0.0 0.3 GO:0017075 syntaxin-1 binding(GO:0017075)
0.0 0.0 GO:0051373 FATZ binding(GO:0051373)
0.0 0.0 GO:0000340 RNA 7-methylguanosine cap binding(GO:0000340)
0.0 0.0 GO:0016971 flavin-linked sulfhydryl oxidase activity(GO:0016971)
0.0 0.0 GO:0004829 threonine-tRNA ligase activity(GO:0004829)
0.0 0.1 GO:0015016 [heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.0 0.2 GO:0008143 poly(A) binding(GO:0008143)
0.0 0.1 GO:0002162 dystroglycan binding(GO:0002162)
0.0 0.1 GO:0016421 CoA carboxylase activity(GO:0016421)
0.0 0.0 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.0 0.0 GO:0030297 transmembrane receptor protein tyrosine kinase activator activity(GO:0030297)
0.0 0.2 GO:0005003 ephrin receptor activity(GO:0005003)
0.0 0.1 GO:0000900 translation repressor activity, nucleic acid binding(GO:0000900)
0.0 0.1 GO:0048406 nerve growth factor binding(GO:0048406)
0.0 0.0 GO:0042296 ISG15 transferase activity(GO:0042296)
0.0 0.0 GO:0004416 hydroxyacylglutathione hydrolase activity(GO:0004416)
0.0 0.1 GO:0005542 folic acid binding(GO:0005542)
0.0 0.1 GO:0031404 chloride ion binding(GO:0031404)
0.0 0.2 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.0 0.9 GO:0004540 ribonuclease activity(GO:0004540)
0.0 0.3 GO:0042165 neurotransmitter binding(GO:0042165)
0.0 0.0 GO:0019198 transmembrane receptor protein phosphatase activity(GO:0019198)
0.0 0.2 GO:0022829 wide pore channel activity(GO:0022829)
0.0 0.0 GO:0097109 neuroligin family protein binding(GO:0097109)
0.0 0.0 GO:0030943 mitochondrion targeting sequence binding(GO:0030943)
0.0 0.1 GO:0005114 type II transforming growth factor beta receptor binding(GO:0005114)
0.0 0.1 GO:0035473 lipase binding(GO:0035473)
0.0 0.0 GO:0032896 palmitoyl-CoA 9-desaturase activity(GO:0032896)
0.0 0.1 GO:0050649 testosterone 6-beta-hydroxylase activity(GO:0050649)
0.0 0.1 GO:0031005 filamin binding(GO:0031005)
0.0 0.0 GO:0019136 deoxynucleoside kinase activity(GO:0019136)
0.0 0.1 GO:0004668 protein-arginine deiminase activity(GO:0004668)
0.0 0.0 GO:0042289 MHC class II protein binding(GO:0042289)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 PID SYNDECAN 2 PATHWAY Syndecan-2-mediated signaling events
0.0 0.8 SA CASPASE CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.0 0.3 PID IL5 PATHWAY IL5-mediated signaling events
0.0 0.5 PID ATM PATHWAY ATM pathway
0.0 0.6 PID PI3KCI AKT PATHWAY Class I PI3K signaling events mediated by Akt
0.0 0.6 PID FOXM1 PATHWAY FOXM1 transcription factor network
0.0 0.2 PID SMAD2 3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.0 0.2 PID EPHA2 FWD PATHWAY EPHA2 forward signaling
0.0 0.0 ST JNK MAPK PATHWAY JNK MAPK Pathway
0.0 0.4 PID EPHB FWD PATHWAY EPHB forward signaling
0.0 0.2 SA B CELL RECEPTOR COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.0 0.1 PID ATF2 PATHWAY ATF-2 transcription factor network
0.0 0.0 ST WNT CA2 CYCLIC GMP PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.0 0.2 PID ARF 3PATHWAY Arf1 pathway
0.0 0.0 PID EPO PATHWAY EPO signaling pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.4 REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Glutamate Neurotransmitter Release Cycle
0.1 0.6 REACTOME MTORC1 MEDIATED SIGNALLING Genes involved in mTORC1-mediated signalling
0.0 0.7 REACTOME APC CDC20 MEDIATED DEGRADATION OF NEK2A Genes involved in APC-Cdc20 mediated degradation of Nek2A
0.0 0.2 REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING Genes involved in Formation of ATP by chemiosmotic coupling
0.0 0.4 REACTOME LYSOSOME VESICLE BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis
0.0 0.2 REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.0 0.3 REACTOME METABOLISM OF PORPHYRINS Genes involved in Metabolism of porphyrins
0.0 0.1 REACTOME BETA DEFENSINS Genes involved in Beta defensins
0.0 0.2 REACTOME COMMON PATHWAY Genes involved in Common Pathway
0.0 0.2 REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins
0.0 0.2 REACTOME REGULATION OF KIT SIGNALING Genes involved in Regulation of KIT signaling
0.0 0.4 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.0 0.3 REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.0 0.3 REACTOME CGMP EFFECTS Genes involved in cGMP effects
0.0 0.5 REACTOME TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT Genes involved in Transport of Mature mRNA Derived from an Intronless Transcript
0.0 0.2 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.0 0.3 REACTOME SULFUR AMINO ACID METABOLISM Genes involved in Sulfur amino acid metabolism
0.0 0.1 REACTOME THE NLRP3 INFLAMMASOME Genes involved in The NLRP3 inflammasome
0.0 0.1 REACTOME REGULATION OF COMPLEMENT CASCADE Genes involved in Regulation of Complement cascade
0.0 0.3 REACTOME MEIOTIC RECOMBINATION Genes involved in Meiotic Recombination
0.0 0.0 REACTOME SEMA4D IN SEMAPHORIN SIGNALING Genes involved in Sema4D in semaphorin signaling
0.0 0.3 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.0 0.2 REACTOME GAP JUNCTION ASSEMBLY Genes involved in Gap junction assembly