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ENCSR904DTN: DNase-seq of mouse liver in constant darkness

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for Rarb

Z-value: 1.93

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Transcription factors associated with Rarb

Gene Symbol	Gene ID	Gene Info
Rarb Ensembl NCBI MGI UniProt	ENSMUSG00000017491.8	Rarb

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

Gene	Promoter	Distance	Association probability	Pearson corr. coef.	P-value	Plot
Rarb	chr14_16573210_16573389	1746	0.364795	-0.96	2.7e-03	Click!
Rarb	chr14_16572962_16573173	1978	0.340832	-0.95	3.0e-03	Click!
Rarb	chr14_16570330_16570481	4640	0.249769	-0.94	5.4e-03	Click!
Rarb	chr14_16735456_16735607	83474	0.100150	0.93	7.4e-03	Click!
Rarb	chr14_16575472_16575639	12	0.517456	0.90	1.4e-02	Click!

Activity of the Rarb motif across conditions

Conditions sorted by the z-value of the Rarb motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr12_71429918_71430089	2.70	1700083H02Rik	RIKEN cDNA 1700083H02 gene	45795	0.12
chr8_94217878_94218059	2.51	Nup93	nucleoporin 93	3362	0.14
chr4_150287636_150287787	2.18	Rere	arginine glutamic acid dipeptide (RE) repeats	5899	0.16
chr6_89138858_89139017	1.91	Gm1965	predicted gene 1965	2057	0.29
chr11_50733265_50733435	1.83	Gm12200	predicted gene 12200	7806	0.16
chr2_114776001_114776450	1.78	Gm13975	predicted gene 13975	68113	0.11
chr3_104541230_104541625	1.77	Lrig2	leucine-rich repeats and immunoglobulin-like domains 2	29509	0.1
chr4_43234117_43234284	1.66	Unc13b	unc-13 homolog B	393	0.84
chr5_118292276_118292427	1.66	Gm25076	predicted gene, 25076	25902	0.16
chr14_51102456_51102668	1.60	Rnase4	ribonuclease, RNase A family 4	6203	0.08
chr8_115644414_115644565	1.48	Gm23677	predicted gene, 23677	53216	0.13
chr5_88969041_88969210	1.38	Slc4a4	solute carrier family 4 (anion exchanger), member 4	34553	0.2
chr19_21038157_21038331	1.36	4930554I06Rik	RIKEN cDNA 4930554I06 gene	66258	0.11
chr8_124345179_124345346	1.32	Gm24459	predicted gene, 24459	11976	0.14
chr5_146107597_146107748	1.19	Cyp3a59	cytochrome P450, family 3, subfamily a, polypeptide 59	28405	0.11
chr19_47385384_47385539	1.17	Sh3pxd2a	SH3 and PX domains 2A	24898	0.18
chr17_56470625_56470795	1.16	Ptprs	protein tyrosine phosphatase, receptor type, S	3917	0.18
chr5_121730204_121730378	1.08	Gm16552	predicted gene 16552	2888	0.16
chr13_40913304_40913608	1.06	Gm48188	predicted gene, 48188	1249	0.3
chr10_84055512_84055676	1.06	Gm37908	predicted gene, 37908	6164	0.21
chr13_79286283_79286457	1.05	Gm29318	predicted gene 29318	658	0.76
chr4_3736363_3736519	1.04	Gm11805	predicted gene 11805	15415	0.15
chr9_109115339_109115519	1.03	Plxnb1	plexin B1	8635	0.1
chrX_42066716_42066867	1.02	Xiap	X-linked inhibitor of apoptosis	1045	0.59
chrX_101391513_101391680	0.99	Gjb1	gap junction protein, beta 1	7860	0.14
chr2_69415195_69415364	0.99	Dhrs9	dehydrogenase/reductase (SDR family) member 9	34834	0.16
chr1_75662127_75662446	0.99	Gm5257	predicted gene 5257	25896	0.15
chr5_64883553_64883984	0.99	AC161757.1	toll-like receptor 1 (Tlr1) pseudogene	15201	0.15
chr8_39639786_39639944	0.98	Msr1	macrophage scavenger receptor 1	2755	0.39
chr5_122693537_122693811	0.98	Gm10064	predicted gene 10064	3926	0.14
chr4_141280593_141280762	0.97	Gm13056	predicted gene 13056	2238	0.18
chr17_24797110_24797261	0.96	Meiob	meiosis specific with OB domains	7104	0.09
chr10_34136560_34136736	0.91	Calhm6	calcium homeostasis modulator family member 6	8664	0.13
chr15_26377246_26377425	0.91	Marchf11	membrane associated ring-CH-type finger 11	10384	0.3
chr17_26687116_26687267	0.90	Atp6v0e	ATPase, H+ transporting, lysosomal V0 subunit E	10779	0.14
chr5_145982849_145983558	0.90	Cyp3a25	cytochrome P450, family 3, subfamily a, polypeptide 25	8440	0.13
chr5_137481993_137482153	0.89	Epo	erythropoietin	3743	0.1
chr7_16229973_16230150	0.86	Gm45409	predicted gene 45409	1161	0.3
chr7_80464871_80465056	0.84	Blm	Bloom syndrome, RecQ like helicase	1086	0.43
chr14_28283569_28283764	0.84	Gm20242	predicted gene, 20242	132331	0.05
chr6_124666813_124667013	0.83	Lpcat3	lysophosphatidylcholine acyltransferase 3	3698	0.1
chr18_46335696_46335862	0.83	4930415P13Rik	RIKEN cDNA 4930415P13 gene	4650	0.16
chr4_44051303_44051454	0.80	Gne	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	3919	0.17
chr10_79887085_79887245	0.80	Elane	elastase, neutrophil expressed	918	0.23
chr12_72763283_72763641	0.79	Ppm1a	protein phosphatase 1A, magnesium dependent, alpha isoform	2147	0.31
chr3_95694014_95694171	0.79	Adamtsl4	ADAMTS-like 4	6175	0.11
chr10_126691394_126691560	0.78	Mir378d	microRNA 378d	18914	0.15
chr12_71875530_71876050	0.78	Daam1	dishevelled associated activator of morphogenesis 1	13940	0.21
chr10_94810057_94810242	0.78	Gm24186	predicted gene, 24186	11506	0.16
chr1_191821111_191821273	0.77	Nek2	NIMA (never in mitosis gene a)-related expressed kinase 2	252	0.8
chr13_55103446_55103605	0.77	Zfp346	zinc finger protein 346	1786	0.23
chr13_93622998_93623302	0.76	Gm15622	predicted gene 15622	2232	0.26
chr15_98915891_98916274	0.76	Lmbr1l	limb region 1 like	130	0.89
chr4_32160991_32161147	0.76	Gm11928	predicted gene 11928	11283	0.21
chr5_16317582_16317767	0.75	Cacna2d1	calcium channel, voltage-dependent, alpha2/delta subunit 1	8311	0.25
chr11_31933098_31933283	0.74	4930524B15Rik	RIKEN cDNA 4930524B15 gene	32402	0.16
chr2_29483450_29483627	0.73	Mir133c	microRNA 133c	8244	0.15
chr12_35739125_35739291	0.73	Gm48264	predicted gene, 48264	7021	0.18
chr3_104214062_104214367	0.73	Magi3	membrane associated guanylate kinase, WW and PDZ domain containing 3	5889	0.12
chr14_55899299_55899513	0.72	Sdr39u1	short chain dehydrogenase/reductase family 39U, member 1	449	0.66
chr8_117337291_117337451	0.70	Cmip	c-Maf inducing protein	11799	0.25
chr6_85864689_85864938	0.70	Nat8f2	N-acetyltransferase 8 (GCN5-related) family member 2	4345	0.1
chr8_11148911_11149083	0.70	Gm44717	predicted gene 44717	249	0.91
chr17_29487122_29487273	0.68	Pim1	proviral integration site 1	3556	0.13
chr5_43156906_43157079	0.68	Gm42552	predicted gene 42552	8665	0.21
chr1_131970433_131970601	0.68	Slc45a3	solute carrier family 45, member 3	92	0.95
chr17_73072435_73072612	0.67	Lclat1	lysocardiolipin acyltransferase 1	35462	0.16
chr4_141287858_141288020	0.67	Gm13056	predicted gene 13056	9500	0.1
chr14_36971294_36971453	0.67	Ccser2	coiled-coil serine rich 2	2596	0.29
chr3_131489084_131489522	0.66	Sgms2	sphingomyelin synthase 2	1176	0.58
chr5_88953989_88954155	0.65	Slc4a4	solute carrier family 4 (anion exchanger), member 4	19500	0.24
chr11_108254783_108254943	0.64	Gm11655	predicted gene 11655	73013	0.09
chr2_84762961_84763125	0.64	Serping1	serine (or cysteine) peptidase inhibitor, clade G, member 1	12085	0.08
chr15_47749931_47750085	0.63	Gm16300	predicted gene 16300	46181	0.17
chr7_68280697_68280888	0.61	Gm16157	predicted gene 16157	4198	0.16
chr11_83409286_83409449	0.61	Rasl10b	RAS-like, family 10, member B	230	0.88
chr9_15442312_15442468	0.61	Gm48634	predicted gene, 48634	1919	0.24
chr18_76051312_76051463	0.60	Zbtb7c	zinc finger and BTB domain containing 7C	8071	0.22
chr10_77109671_77109843	0.60	Col18a1	collagen, type XVIII, alpha 1	3948	0.21
chr15_8968437_8968609	0.60	Ranbp3l	RAN binding protein 3-like	97	0.97
chr7_112121062_112121238	0.59	Usp47	ubiquitin specific peptidase 47	30444	0.19
chr11_86989298_86989461	0.59	Ypel2	yippee like 2	4328	0.19
chr6_72212736_72212914	0.59	Atoh8	atonal bHLH transcription factor 8	21712	0.14
chr17_24478264_24478594	0.59	Mlst8	MTOR associated protein, LST8 homolog (S. cerevisiae)	49	0.92
chr8_69063559_69063737	0.59	Slc18a1	solute carrier family 18 (vesicular monoamine), member 1	11860	0.15
chr2_38925242_38925421	0.59	Nr6a1	nuclear receptor subfamily 6, group A, member 1	886	0.43
chr11_69842335_69842486	0.58	Tmem256	transmembrane protein 256	3772	0.07
chr4_133338574_133338734	0.58	Wdtc1	WD and tetratricopeptide repeats 1	617	0.65
chr9_70248725_70249019	0.58	Myo1e	myosin IE	41504	0.15
chr8_33904851_33905143	0.57	Rbpms	RNA binding protein gene with multiple splicing	13233	0.17
chr7_101465911_101466071	0.57	Pde2a	phosphodiesterase 2A, cGMP-stimulated	5047	0.16
chr16_24154494_24154889	0.57	Gm32126	predicted gene, 32126	13870	0.2
chr2_25266466_25266742	0.57	Tprn	taperin	960	0.23
chr2_103811926_103812077	0.56	Gm13878	predicted gene 13878	384	0.68
chr10_63226846_63227134	0.56	Herc4	hect domain and RLD 4	16820	0.11
chr11_95038769_95038930	0.56	Pdk2	pyruvate dehydrogenase kinase, isoenzyme 2	1709	0.23
chr9_83866290_83866453	0.55	Ttk	Ttk protein kinase	31605	0.14
chr6_129175697_129175889	0.55	Gm26160	predicted gene, 26160	973	0.41
chr2_113537620_113538205	0.55	Gm13964	predicted gene 13964	33878	0.16
chr4_130112167_130112332	0.55	Pef1	penta-EF hand domain containing 1	4693	0.16
chr11_106502645_106502807	0.54	Gm22711	predicted gene, 22711	1481	0.29
chr5_134279549_134279704	0.54	Gtf2i	general transcription factor II I	239	0.89
chr6_95819185_95819380	0.54	Suclg2	succinate-Coenzyme A ligase, GDP-forming, beta subunit	100482	0.08
chr9_35136038_35136227	0.54	Gm24262	predicted gene, 24262	8504	0.12
chr18_67958643_67958805	0.54	Ldlrad4	low density lipoprotein receptor class A domain containing 4	25467	0.19
chrX_155337365_155337828	0.53	Prdx4	peroxiredoxin 4	871	0.59
chr5_121665076_121665253	0.52	Brap	BRCA1 associated protein	1362	0.3
chr14_20638160_20638341	0.52	2810402E24Rik	RIKEN cDNA 2810402E24 gene	2759	0.13
chr4_119259446_119259606	0.51	Gm12927	predicted gene 12927	2551	0.13
chr8_121562702_121562861	0.51	Fbxo31	F-box protein 31	2818	0.16
chr5_113735107_113735259	0.51	Ficd	FIC domain containing	620	0.6
chr11_120726590_120726778	0.51	Dcxr	dicarbonyl L-xylulose reductase	545	0.48
chr14_122765965_122766143	0.51	Pcca	propionyl-Coenzyme A carboxylase, alpha polypeptide	24345	0.21
chr5_134170407_134170687	0.50	Rcc1l	reculator of chromosome condensation 1 like	1172	0.37
chr4_140636700_140636879	0.50	Arhgef10l	Rho guanine nucleotide exchange factor (GEF) 10-like	11961	0.16
chr2_121968638_121968832	0.49	Ctdspl2	CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2	347	0.85
chr15_36904059_36904218	0.49	Gm10384	predicted gene 10384	24322	0.13
chr3_108804290_108804468	0.49	Stxbp3	syntaxin binding protein 3	1352	0.39
chr9_116947417_116947569	0.49	Gm18489	predicted gene, 18489	111665	0.07
chr17_20287010_20287161	0.49	Vmn2r106	vomeronasal 2, receptor 106	1532	0.35
chr10_121455166_121455317	0.48	Rassf3	Ras association (RalGDS/AF-6) domain family member 3	6972	0.13
chr15_64273225_64273401	0.47	Asap1	ArfGAP with SH3 domain, ankyrin repeat and PH domain1	38376	0.15
chr2_31530318_31530475	0.47	Ass1	argininosuccinate synthetase 1	11906	0.15
chr15_36914757_36914955	0.47	Gm41300	predicted gene, 41300	16830	0.15
chr7_141337790_141337972	0.47	Eps8l2	EPS8-like 2	999	0.3
chr16_4757027_4757557	0.46	Hmox2	heme oxygenase 2	298	0.84
chr5_74813446_74813635	0.46	Gm42575	predicted gene 42575	63658	0.09
chr13_28757565_28757740	0.46	Mir6368	microRNA 6368	46779	0.15
chr11_21058339_21058501	0.46	Peli1	pellino 1	32871	0.16
chr11_70745785_70745982	0.46	Gm12320	predicted gene 12320	9268	0.08
chr15_102171688_102171839	0.46	Csad	cysteine sulfinic acid decarboxylase	7256	0.1
chr7_123850432_123850600	0.46	Gm23788	predicted gene, 23788	91693	0.08
chr8_71307755_71307928	0.46	Myo9b	myosin IXb	25976	0.11
chr18_20938375_20938560	0.46	Rnf125	ring finger protein 125	6158	0.22
chr11_75661487_75661650	0.45	Myo1c	myosin IC	165	0.92
chr15_99790865_99791044	0.45	Lima1	LIM domain and actin binding 1	6981	0.09
chr11_105237702_105237861	0.45	Tlk2	tousled-like kinase 2 (Arabidopsis)	8977	0.19
chrX_60831870_60832021	0.45	Gm14660	predicted gene 14660	13737	0.19
chr5_81908094_81908272	0.45	2900064F13Rik	RIKEN cDNA 2900064F13 gene	81367	0.1
chr7_80830498_80830680	0.44	Iqgap1	IQ motif containing GTPase activating protein 1	4615	0.18
chr13_32169128_32169451	0.44	Gmds	GDP-mannose 4, 6-dehydratase	57952	0.13
chr2_12060466_12060629	0.44	Gm13310	predicted gene 13310	23445	0.21
chr17_47888408_47888575	0.43	Foxp4	forkhead box P4	58	0.96
chr11_78698801_78698963	0.43	Nlk	nemo like kinase	1509	0.33
chr11_44173581_44173732	0.43	Gm12154	predicted gene 12154	93553	0.08
chr13_31171886_31172048	0.43	Gm11372	predicted gene 11372	27119	0.19
chr7_134497184_134497335	0.43	D7Ertd443e	DNA segment, Chr 7, ERATO Doi 443, expressed	1725	0.51
chr3_115682777_115683090	0.43	S1pr1	sphingosine-1-phosphate receptor 1	32139	0.17
chr2_80600719_80600876	0.43	Gm13688	predicted gene 13688	1936	0.21
chr4_11147830_11148134	0.42	Gm11830	predicted gene 11830	3272	0.15
chr18_38205562_38205736	0.42	Pcdh1	protocadherin 1	1809	0.24
chr16_21865351_21865519	0.41	Gm26744	predicted gene, 26744	19659	0.11
chr7_110920925_110921090	0.41	Mrvi1	MRV integration site 1	2696	0.25
chr5_149198922_149199082	0.41	Uspl1	ubiquitin specific peptidase like 1	7666	0.09
chr2_151925877_151926031	0.40	Angpt4	angiopoietin 4	14744	0.13
chr2_3770483_3770646	0.39	Fam107b	family with sequence similarity 107, member B	144	0.96
chr17_88509210_88509380	0.39	Ppp1r21	protein phosphatase 1, regulatory subunit 21	20823	0.16
chr18_60769849_60770150	0.39	Rps14	ribosomal protein S14	4597	0.15
chr11_119954339_119954501	0.39	Baiap2	brain-specific angiogenesis inhibitor 1-associated protein 2	5601	0.13
chr9_77927047_77927209	0.38	Elovl5	ELOVL family member 5, elongation of long chain fatty acids (yeast)	5196	0.17
chr11_35783421_35783583	0.38	Mir103-1	microRNA 103-1	1106	0.43
chr1_7104338_7104546	0.38	Pcmtd1	protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1	15276	0.15
chr16_23218528_23218719	0.38	St6gal1	beta galactoside alpha 2,6 sialyltransferase 1	6117	0.11
chr6_49210657_49210827	0.38	Igf2bp3	insulin-like growth factor 2 mRNA binding protein 3	3419	0.2
chr10_108449802_108449991	0.38	Gm36283	predicted gene, 36283	3294	0.25
chr9_45833631_45833782	0.38	Gm7286	predicted gene 7286	3229	0.12
chr12_80146592_80146753	0.38	2310015A10Rik	RIKEN cDNA 2310015A10 gene	13828	0.12
chr9_44406569_44406995	0.37	Trappc4	trafficking protein particle complex 4	260	0.51
chr3_85786657_85786819	0.37	Fam160a1	family with sequence similarity 160, member A1	30553	0.16
chr5_112344431_112344696	0.37	Hps4	HPS4, biogenesis of lysosomal organelles complex 3 subunit 2	1463	0.2
chr2_75999812_75999973	0.37	Pde11a	phosphodiesterase 11A	6151	0.18
chr10_14035731_14035911	0.37	Hivep2	human immunodeficiency virus type I enhancer binding protein 2	68797	0.09
chr5_107272625_107272804	0.37	Gm42900	predicted gene 42900	16210	0.12
chr17_84026540_84026710	0.36	Gm35551	predicted gene, 35551	606	0.62
chr7_5021714_5021881	0.36	Zfp865	zinc finger protein 865	1210	0.17
chr18_24652431_24652590	0.36	Mocos	molybdenum cofactor sulfurase	1181	0.43
chr12_100191588_100191746	0.35	Gm10433	predicted gene 10433	2894	0.18
chr12_21136203_21136399	0.35	Asap2	ArfGAP with SH3 domain, ankyrin repeat and PH domain 2	24347	0.18
chr3_68593185_68593343	0.35	Schip1	schwannomin interacting protein 1	2911	0.3
chr12_87408323_87408513	0.35	Gm8557	predicted gene 8557	12093	0.07
chr14_63246048_63246212	0.35	Gata4	GATA binding protein 4	859	0.59
chr8_111775967_111776118	0.35	Bcar1	breast cancer anti-estrogen resistance 1	32233	0.14
chr1_36571715_36571905	0.35	D430040D24Rik	RIKEN cDNA D430040D24 gene	13451	0.09
chrX_99138009_99138168	0.35	Efnb1	ephrin B1	43	0.98
chr16_23592594_23592752	0.35	Rtp4	receptor transporter protein 4	9069	0.21
chr6_124528028_124528336	0.35	Gm16567	predicted gene 16567	2729	0.14
chr4_137471059_137471217	0.35	Hspg2	perlecan (heparan sulfate proteoglycan 2)	2335	0.21
chr9_63534222_63534551	0.34	Gm16759	predicted gene, 16759	3034	0.28
chr4_134488308_134488479	0.34	Gm13250	predicted gene 13250	4829	0.11
chr6_116415099_116415265	0.34	Alox5	arachidonate 5-lipoxygenase	1162	0.37
chr5_111336024_111336199	0.34	Pitpnb	phosphatidylinositol transfer protein, beta	5304	0.19
chr15_36585261_36585431	0.34	Gm44310	predicted gene, 44310	1802	0.26
chr12_79689447_79689598	0.34	9430078K24Rik	RIKEN cDNA 9430078K24 gene	235211	0.02
chr5_147880674_147880894	0.33	Slc46a3	solute carrier family 46, member 3	915	0.53
chr10_18074695_18074946	0.33	Reps1	RalBP1 associated Eps domain containing protein	16648	0.19
chr7_98141341_98141502	0.33	Omp	olfactory marker protein	4081	0.18
chr7_127811270_127811556	0.33	Stx1b	syntaxin 1B	489	0.54
chr1_157526751_157526916	0.33	Sec16b	SEC16 homolog B (S. cerevisiae)	686	0.65
chr5_107834436_107834622	0.33	Evi5	ecotropic viral integration site 5	2951	0.15
chr13_98944666_98945270	0.32	Gm35215	predicted gene, 35215	948	0.45

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of Rarb

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.5	1.4	GO:2000302	positive regulation of synaptic vesicle exocytosis(GO:2000302)
0.2	0.6	GO:0015770	disaccharide transport(GO:0015766) sucrose transport(GO:0015770) oligosaccharide transport(GO:0015772)
0.2	0.6	GO:0030997	regulation of centriole-centriole cohesion(GO:0030997)
0.1	0.6	GO:0097039	protein linear polyubiquitination(GO:0097039)
0.1	0.4	GO:1900748	positive regulation of vascular endothelial growth factor signaling pathway(GO:1900748)
0.1	0.3	GO:0021699	cerebellar cortex maturation(GO:0021699)
0.1	0.4	GO:0006787	porphyrin-containing compound catabolic process(GO:0006787) tetrapyrrole catabolic process(GO:0033015)
0.1	0.4	GO:0045950	negative regulation of mitotic recombination(GO:0045950)
0.1	0.4	GO:0060480	lung goblet cell differentiation(GO:0060480)
0.1	0.3	GO:0035054	embryonic heart tube anterior/posterior pattern specification(GO:0035054)
0.1	0.3	GO:2000255	negative regulation of male germ cell proliferation(GO:2000255)
0.1	0.2	GO:0042732	D-xylose metabolic process(GO:0042732)
0.1	0.4	GO:0006686	sphingomyelin biosynthetic process(GO:0006686)
0.1	0.3	GO:0010273	detoxification of copper ion(GO:0010273) stress response to copper ion(GO:1990169)
0.1	1.2	GO:0046827	positive regulation of protein export from nucleus(GO:0046827)
0.1	0.2	GO:0048207	vesicle targeting, rough ER to cis-Golgi(GO:0048207) COPII vesicle coating(GO:0048208)
0.1	0.2	GO:0048320	axial mesoderm formation(GO:0048320)
0.1	0.4	GO:0010886	positive regulation of cholesterol storage(GO:0010886)
0.1	0.2	GO:1901843	positive regulation of high voltage-gated calcium channel activity(GO:1901843)
0.1	0.2	GO:0061669	spontaneous neurotransmitter secretion(GO:0061669) spontaneous synaptic transmission(GO:0098814)
0.1	0.2	GO:2000670	positive regulation of dendritic cell apoptotic process(GO:2000670)
0.1	0.2	GO:0045079	negative regulation of chemokine biosynthetic process(GO:0045079)
0.0	0.3	GO:0045213	neurotransmitter receptor metabolic process(GO:0045213)
0.0	0.2	GO:0072675	osteoclast fusion(GO:0072675)
0.0	0.1	GO:0010735	positive regulation of transcription via serum response element binding(GO:0010735)
0.0	0.1	GO:0002540	leukotriene production involved in inflammatory response(GO:0002540)
0.0	0.1	GO:0070340	detection of bacterial lipopeptide(GO:0070340)
0.0	0.1	GO:0050717	positive regulation of interleukin-1 alpha secretion(GO:0050717)
0.0	0.1	GO:1902564	negative regulation of neutrophil activation(GO:1902564)
0.0	0.4	GO:0051292	nuclear pore complex assembly(GO:0051292)
0.0	0.2	GO:0071712	ER-associated misfolded protein catabolic process(GO:0071712)
0.0	0.2	GO:0072310	glomerular visceral epithelial cell development(GO:0072015) glomerular epithelial cell development(GO:0072310)
0.0	0.1	GO:0000101	sulfur amino acid transport(GO:0000101)
0.0	0.3	GO:0072378	blood coagulation, fibrin clot formation(GO:0072378)
0.0	0.1	GO:1903223	positive regulation of oxidative stress-induced neuron death(GO:1903223)
0.0	0.1	GO:2000065	negative regulation of aldosterone metabolic process(GO:0032345) negative regulation of aldosterone biosynthetic process(GO:0032348) negative regulation of cortisol biosynthetic process(GO:2000065)
0.0	0.1	GO:0006651	diacylglycerol biosynthetic process(GO:0006651)
0.0	0.2	GO:0090557	establishment of endothelial intestinal barrier(GO:0090557)
0.0	0.1	GO:0030208	dermatan sulfate biosynthetic process(GO:0030208)
0.0	0.5	GO:0014733	regulation of skeletal muscle adaptation(GO:0014733)
0.0	0.1	GO:0070537	histone H2A K63-linked deubiquitination(GO:0070537)
0.0	0.1	GO:0010510	regulation of acetyl-CoA biosynthetic process from pyruvate(GO:0010510)
0.0	0.2	GO:0006777	Mo-molybdopterin cofactor biosynthetic process(GO:0006777) Mo-molybdopterin cofactor metabolic process(GO:0019720) molybdopterin cofactor biosynthetic process(GO:0032324) molybdopterin cofactor metabolic process(GO:0043545) prosthetic group metabolic process(GO:0051189)
0.0	0.1	GO:0009093	cysteine catabolic process(GO:0009093) L-cysteine catabolic process(GO:0019448) L-cysteine metabolic process(GO:0046439)
0.0	0.1	GO:0048619	embryonic hindgut morphogenesis(GO:0048619)
0.0	0.1	GO:0002378	immunoglobulin biosynthetic process(GO:0002378)
0.0	0.0	GO:2000645	negative regulation of receptor catabolic process(GO:2000645)
0.0	0.0	GO:0097029	mature conventional dendritic cell differentiation(GO:0097029)
0.0	0.1	GO:1903377	negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903377)
0.0	0.4	GO:0045717	negative regulation of fatty acid biosynthetic process(GO:0045717)
0.0	0.1	GO:1900126	negative regulation of hyaluronan biosynthetic process(GO:1900126)
0.0	0.1	GO:0006015	5-phosphoribose 1-diphosphate biosynthetic process(GO:0006015) 5-phosphoribose 1-diphosphate metabolic process(GO:0046391)
0.0	0.1	GO:0097212	lysosomal membrane organization(GO:0097212)
0.0	0.1	GO:0007354	zygotic determination of anterior/posterior axis, embryo(GO:0007354)
0.0	0.1	GO:0033159	negative regulation of protein import into nucleus, translocation(GO:0033159)
0.0	0.1	GO:1902219	intrinsic apoptotic signaling pathway in response to osmotic stress(GO:0008627) regulation of intrinsic apoptotic signaling pathway in response to osmotic stress(GO:1902218) negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress(GO:1902219)
0.0	0.1	GO:0097503	sialylation(GO:0097503)
0.0	0.1	GO:1900029	positive regulation of ruffle assembly(GO:1900029)
0.0	0.2	GO:0006689	ganglioside catabolic process(GO:0006689)
0.0	0.1	GO:0060005	vestibular reflex(GO:0060005)
0.0	0.1	GO:0061110	dense core granule biogenesis(GO:0061110)
0.0	0.2	GO:0071267	amino acid salvage(GO:0043102) L-methionine biosynthetic process(GO:0071265) L-methionine salvage(GO:0071267)
0.0	0.1	GO:2000359	regulation of binding of sperm to zona pellucida(GO:2000359)
0.0	0.1	GO:0036438	maintenance of lens transparency(GO:0036438)
0.0	0.1	GO:0019344	cysteine biosynthetic process(GO:0019344)
0.0	0.1	GO:0010991	negative regulation of SMAD protein complex assembly(GO:0010991)
0.0	0.1	GO:1900169	regulation of glucocorticoid mediated signaling pathway(GO:1900169)
0.0	0.1	GO:0010046	response to mycotoxin(GO:0010046)
0.0	0.1	GO:0051581	negative regulation of neurotransmitter uptake(GO:0051581) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612)
0.0	0.0	GO:0061341	non-canonical Wnt signaling pathway involved in heart development(GO:0061341) planar cell polarity pathway involved in heart morphogenesis(GO:0061346)
0.0	0.1	GO:0006398	mRNA 3'-end processing by stem-loop binding and cleavage(GO:0006398)
0.0	0.2	GO:0070561	vitamin D receptor signaling pathway(GO:0070561)
0.0	0.2	GO:0035999	tetrahydrofolate interconversion(GO:0035999)
0.0	0.1	GO:0060744	thelarche(GO:0042695) mammary gland branching involved in thelarche(GO:0060744)
0.0	0.1	GO:0051771	negative regulation of nitric-oxide synthase biosynthetic process(GO:0051771)
0.0	0.1	GO:0072553	terminal button organization(GO:0072553)
0.0	0.1	GO:0019805	quinolinate biosynthetic process(GO:0019805)
0.0	0.2	GO:0042904	9-cis-retinoic acid biosynthetic process(GO:0042904) 9-cis-retinoic acid metabolic process(GO:0042905)
0.0	0.1	GO:0035590	purinergic nucleotide receptor signaling pathway(GO:0035590)
0.0	0.1	GO:0070295	renal water absorption(GO:0070295)
0.0	0.2	GO:0022615	protein to membrane docking(GO:0022615)
0.0	0.1	GO:0034773	histone H4-K20 trimethylation(GO:0034773)
0.0	0.1	GO:0015868	purine ribonucleotide transport(GO:0015868)
0.0	0.2	GO:0019934	cGMP-mediated signaling(GO:0019934)
0.0	0.4	GO:0015701	bicarbonate transport(GO:0015701)
0.0	0.1	GO:0042997	negative regulation of Golgi to plasma membrane protein transport(GO:0042997)
0.0	0.2	GO:1903025	regulation of RNA polymerase II regulatory region sequence-specific DNA binding(GO:1903025)
0.0	0.0	GO:0003347	epicardial cell to mesenchymal cell transition(GO:0003347)
0.0	0.2	GO:0033136	serine phosphorylation of STAT3 protein(GO:0033136)
0.0	0.1	GO:0044339	canonical Wnt signaling pathway involved in osteoblast differentiation(GO:0044339)
0.0	0.0	GO:1900623	regulation of monocyte aggregation(GO:1900623) positive regulation of monocyte aggregation(GO:1900625)
0.0	0.0	GO:0070640	vitamin D3 metabolic process(GO:0070640)
0.0	0.1	GO:0030050	vesicle transport along actin filament(GO:0030050)
0.0	0.1	GO:1902093	positive regulation of sperm motility(GO:1902093)
0.0	0.0	GO:2000338	chemokine (C-X-C motif) ligand 1 production(GO:0072566) regulation of chemokine (C-X-C motif) ligand 1 production(GO:2000338)
0.0	0.1	GO:0034141	positive regulation of toll-like receptor 3 signaling pathway(GO:0034141)
0.0	0.1	GO:2000623	regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000622) negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000623)
0.0	0.1	GO:0000710	meiotic mismatch repair(GO:0000710)
0.0	0.1	GO:2000766	negative regulation of cytoplasmic translation(GO:2000766)
0.0	0.1	GO:0002430	complement receptor mediated signaling pathway(GO:0002430)
0.0	0.1	GO:0030242	pexophagy(GO:0030242)
0.0	0.1	GO:0030576	Cajal body organization(GO:0030576)
0.0	0.2	GO:0001886	endothelial cell morphogenesis(GO:0001886)
0.0	0.1	GO:0044314	protein K27-linked ubiquitination(GO:0044314)
0.0	0.1	GO:0019367	fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.0	0.2	GO:0007095	mitotic G2 DNA damage checkpoint(GO:0007095)
0.0	0.1	GO:0002091	negative regulation of receptor internalization(GO:0002091)
0.0	0.1	GO:0035520	monoubiquitinated protein deubiquitination(GO:0035520)
0.0	0.1	GO:0036289	peptidyl-serine autophosphorylation(GO:0036289)
0.0	0.0	GO:1901874	regulation of post-translational protein modification(GO:1901873) negative regulation of post-translational protein modification(GO:1901874)
0.0	0.0	GO:1900825	regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900825)
0.0	0.1	GO:0003241	growth involved in heart morphogenesis(GO:0003241)
0.0	0.0	GO:0015755	fructose transport(GO:0015755)
0.0	0.5	GO:0032008	positive regulation of TOR signaling(GO:0032008)
0.0	0.1	GO:0046598	positive regulation of viral entry into host cell(GO:0046598)
0.0	0.0	GO:0046655	folic acid metabolic process(GO:0046655)
0.0	0.4	GO:0031295	T cell costimulation(GO:0031295)
0.0	0.1	GO:1900086	regulation of peptidyl-tyrosine autophosphorylation(GO:1900084) positive regulation of peptidyl-tyrosine autophosphorylation(GO:1900086)
0.0	0.1	GO:0033689	negative regulation of osteoblast proliferation(GO:0033689)
0.0	0.0	GO:0097680	double-strand break repair via classical nonhomologous end joining(GO:0097680)
0.0	0.0	GO:0051365	cellular response to potassium ion starvation(GO:0051365)
0.0	0.1	GO:0001867	complement activation, lectin pathway(GO:0001867)
0.0	0.0	GO:0090038	negative regulation of protein kinase C signaling(GO:0090038)
0.0	0.1	GO:0006054	N-acetylneuraminate metabolic process(GO:0006054)
0.0	0.1	GO:0003383	apical constriction(GO:0003383)
0.0	0.0	GO:0060178	regulation of exocyst localization(GO:0060178)
0.0	0.1	GO:1904707	positive regulation of vascular smooth muscle cell proliferation(GO:1904707)
0.0	0.1	GO:0033623	regulation of integrin activation(GO:0033623)
0.0	0.1	GO:0070986	left/right axis specification(GO:0070986)
0.0	0.1	GO:0033622	integrin activation(GO:0033622)
0.0	0.0	GO:0003431	growth plate cartilage chondrocyte development(GO:0003431)
0.0	0.3	GO:0030970	retrograde protein transport, ER to cytosol(GO:0030970)
0.0	0.0	GO:0070375	ERK5 cascade(GO:0070375)
0.0	0.0	GO:0006435	threonyl-tRNA aminoacylation(GO:0006435)
0.0	0.1	GO:0097062	dendritic spine maintenance(GO:0097062)
0.0	0.1	GO:0051764	actin crosslink formation(GO:0051764)
0.0	0.1	GO:0072321	chaperone-mediated protein transport(GO:0072321)
0.0	0.2	GO:0010640	regulation of platelet-derived growth factor receptor signaling pathway(GO:0010640)
0.0	0.0	GO:0010748	negative regulation of plasma membrane long-chain fatty acid transport(GO:0010748)
0.0	0.1	GO:0046618	drug export(GO:0046618)
0.0	0.0	GO:0038108	negative regulation of appetite by leptin-mediated signaling pathway(GO:0038108)
0.0	0.0	GO:0048014	Tie signaling pathway(GO:0048014)
0.0	0.1	GO:0015808	L-alanine transport(GO:0015808)
0.0	0.0	GO:0018364	peptidyl-glutamine methylation(GO:0018364)
0.0	0.1	GO:1904996	positive regulation of leukocyte adhesion to vascular endothelial cell(GO:1904996)
0.0	0.0	GO:2000721	positive regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation(GO:2000721)
0.0	0.1	GO:0035385	Roundabout signaling pathway(GO:0035385)
0.0	0.0	GO:0033861	negative regulation of NAD(P)H oxidase activity(GO:0033861)
0.0	0.1	GO:0051005	negative regulation of lipoprotein lipase activity(GO:0051005)
0.0	0.5	GO:0001990	regulation of systemic arterial blood pressure by hormone(GO:0001990)
0.0	0.0	GO:0009804	coumarin metabolic process(GO:0009804)
0.0	0.0	GO:0030423	targeting of mRNA for destruction involved in RNA interference(GO:0030423)
0.0	0.0	GO:0090245	axis elongation involved in somitogenesis(GO:0090245)
0.0	0.1	GO:0006857	oligopeptide transport(GO:0006857)
0.0	0.0	GO:1903964	monounsaturated fatty acid metabolic process(GO:1903964) monounsaturated fatty acid biosynthetic process(GO:1903966)
0.0	0.0	GO:0032876	negative regulation of DNA endoreduplication(GO:0032876)
0.0	0.1	GO:1902018	negative regulation of cilium assembly(GO:1902018)
0.0	0.0	GO:0071926	cannabinoid signaling pathway(GO:0038171) endocannabinoid signaling pathway(GO:0071926)
0.0	0.0	GO:1901078	negative regulation of relaxation of muscle(GO:1901078)
0.0	0.1	GO:0018101	protein citrullination(GO:0018101)
0.0	0.1	GO:0000712	resolution of meiotic recombination intermediates(GO:0000712)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.4	GO:0030313	cell outer membrane(GO:0009279) cell envelope(GO:0030313) external encapsulating structure part(GO:0044462)
0.1	0.4	GO:0016461	unconventional myosin complex(GO:0016461)
0.1	0.6	GO:0031931	TORC1 complex(GO:0031931)
0.0	0.3	GO:0030008	TRAPP complex(GO:0030008)
0.0	0.1	GO:0034666	integrin alpha2-beta1 complex(GO:0034666)
0.0	0.1	GO:0035355	Toll-like receptor 2-Toll-like receptor 6 protein complex(GO:0035355)
0.0	0.2	GO:0070820	tertiary granule(GO:0070820)
0.0	0.2	GO:0000276	mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.0	0.1	GO:1990604	IRE1-TRAF2-ASK1 complex(GO:1990604)
0.0	0.3	GO:0034362	low-density lipoprotein particle(GO:0034362)
0.0	0.2	GO:1990454	L-type voltage-gated calcium channel complex(GO:1990454)
0.0	0.2	GO:0005577	fibrinogen complex(GO:0005577)
0.0	0.4	GO:0000800	lateral element(GO:0000800)
0.0	0.0	GO:0032127	dense core granule membrane(GO:0032127)
0.0	1.4	GO:0031594	neuromuscular junction(GO:0031594)
0.0	0.1	GO:0070531	BRCA1-A complex(GO:0070531)
0.0	0.2	GO:0005641	nuclear envelope lumen(GO:0005641)
0.0	0.1	GO:0031298	replication fork protection complex(GO:0031298)
0.0	0.2	GO:1990124	messenger ribonucleoprotein complex(GO:1990124)
0.0	0.2	GO:0036513	Derlin-1 retrotranslocation complex(GO:0036513)
0.0	0.1	GO:0009331	glycerol-3-phosphate dehydrogenase complex(GO:0009331)
0.0	0.1	GO:0042827	platelet dense granule(GO:0042827)
0.0	0.1	GO:0034673	inhibin-betaglycan-ActRII complex(GO:0034673)
0.0	0.1	GO:0030062	mitochondrial tricarboxylic acid cycle enzyme complex(GO:0030062)
0.0	0.0	GO:0097057	TRAF2-GSTP1 complex(GO:0097057)
0.0	0.1	GO:0030130	clathrin coat of trans-Golgi network vesicle(GO:0030130)
0.0	0.1	GO:0042719	mitochondrial intermembrane space protein transporter complex(GO:0042719)
0.0	0.1	GO:0033179	proton-transporting V-type ATPase, V0 domain(GO:0033179)
0.0	0.1	GO:0042382	paraspeckles(GO:0042382)
0.0	0.0	GO:0031092	platelet alpha granule membrane(GO:0031092)
0.0	0.1	GO:0005796	Golgi lumen(GO:0005796)
0.0	0.1	GO:0034098	VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)
0.0	0.3	GO:0030992	intraciliary transport particle B(GO:0030992)
0.0	0.0	GO:0035838	growing cell tip(GO:0035838)
0.0	0.1	GO:0033269	internode region of axon(GO:0033269)
0.0	0.1	GO:0097136	Bcl-2 family protein complex(GO:0097136)
0.0	0.0	GO:0071001	U4/U6 snRNP(GO:0071001)
0.0	0.0	GO:1990393	3M complex(GO:1990393)
0.0	0.0	GO:0071438	invadopodium membrane(GO:0071438)
0.0	0.1	GO:0033180	proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.0	0.2	GO:0005605	basal lamina(GO:0005605)
0.0	0.1	GO:0070419	nonhomologous end joining complex(GO:0070419)
0.0	0.0	GO:0012510	trans-Golgi network transport vesicle membrane(GO:0012510)
0.0	0.1	GO:0032591	dendritic spine membrane(GO:0032591)
0.0	0.2	GO:0045334	clathrin-coated endocytic vesicle(GO:0045334)
0.0	0.2	GO:0005849	mRNA cleavage factor complex(GO:0005849)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	0.6	GO:0015157	sucrose:proton symporter activity(GO:0008506) sucrose transmembrane transporter activity(GO:0008515) disaccharide transmembrane transporter activity(GO:0015154) oligosaccharide transmembrane transporter activity(GO:0015157)
0.2	1.4	GO:0019992	diacylglycerol binding(GO:0019992)
0.1	0.4	GO:0051880	G-quadruplex DNA binding(GO:0051880)
0.1	0.2	GO:0005128	erythropoietin receptor binding(GO:0005128)
0.1	0.3	GO:0036435	K48-linked polyubiquitin binding(GO:0036435)
0.1	0.3	GO:0033192	calmodulin-dependent protein phosphatase activity(GO:0033192)
0.1	0.3	GO:0008390	testosterone 16-alpha-hydroxylase activity(GO:0008390)
0.1	0.3	GO:0017034	Rap guanyl-nucleotide exchange factor activity(GO:0017034)
0.1	0.2	GO:0016882	cyclo-ligase activity(GO:0016882)
0.1	0.2	GO:0035663	Toll-like receptor 2 binding(GO:0035663)
0.1	0.2	GO:0008898	S-adenosylmethionine-homocysteine S-methyltransferase activity(GO:0008898)
0.0	0.1	GO:0097200	cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:0097200)
0.0	0.3	GO:0051920	peroxiredoxin activity(GO:0051920)
0.0	0.1	GO:0050692	DBD domain binding(GO:0050692)
0.0	0.2	GO:0004634	phosphopyruvate hydratase activity(GO:0004634)
0.0	0.1	GO:0017150	tRNA dihydrouridine synthase activity(GO:0017150)
0.0	0.2	GO:0051525	NFAT protein binding(GO:0051525)
0.0	0.2	GO:0004563	beta-N-acetylhexosaminidase activity(GO:0004563)
0.0	0.2	GO:0016176	superoxide-generating NADPH oxidase activator activity(GO:0016176)
0.0	0.1	GO:0005148	prolactin receptor binding(GO:0005148)
0.0	0.0	GO:0035276	ethanol binding(GO:0035276)
0.0	0.1	GO:0004942	anaphylatoxin receptor activity(GO:0004942)
0.0	0.1	GO:0004740	pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740)
0.0	0.2	GO:1990381	ubiquitin-specific protease binding(GO:1990381)
0.0	0.7	GO:0070412	R-SMAD binding(GO:0070412)
0.0	0.2	GO:0004022	alcohol dehydrogenase (NAD) activity(GO:0004022)
0.0	0.2	GO:0035381	extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381)
0.0	0.2	GO:0030151	molybdenum ion binding(GO:0030151)
0.0	0.1	GO:0071987	WD40-repeat domain binding(GO:0071987)
0.0	0.1	GO:0015222	serotonin transmembrane transporter activity(GO:0015222)
0.0	0.4	GO:0015106	bicarbonate transmembrane transporter activity(GO:0015106)
0.0	0.1	GO:0008310	single-stranded DNA 3'-5' exodeoxyribonuclease activity(GO:0008310)
0.0	0.6	GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.0	0.1	GO:0008532	N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity(GO:0008532)
0.0	0.2	GO:0016857	racemase and epimerase activity, acting on carbohydrates and derivatives(GO:0016857)
0.0	0.1	GO:0043423	3-phosphoinositide-dependent protein kinase binding(GO:0043423)
0.0	0.6	GO:0001106	RNA polymerase II transcription corepressor activity(GO:0001106)
0.0	0.4	GO:0017056	structural constituent of nuclear pore(GO:0017056)
0.0	0.1	GO:0030911	TPR domain binding(GO:0030911)
0.0	0.1	GO:0000099	sulfur amino acid transmembrane transporter activity(GO:0000099)
0.0	0.1	GO:0005280	hydrogen:amino acid symporter activity(GO:0005280)
0.0	0.1	GO:0031849	olfactory receptor binding(GO:0031849)
0.0	0.6	GO:0051019	mitogen-activated protein kinase binding(GO:0051019)
0.0	0.5	GO:0052830	phosphohistidine phosphatase activity(GO:0008969) inositol-1,3,4-trisphosphate 4-phosphatase activity(GO:0017161) NADP phosphatase activity(GO:0019178) 5-amino-6-(5-phosphoribitylamino)uracil phosphatase activity(GO:0043726) phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity(GO:0043813) inositol-1,3,4,5,6-pentakisphosphate 1-phosphatase activity(GO:0052825) inositol-3,4-bisphosphate 4-phosphatase activity(GO:0052828) inositol-1,3,4-trisphosphate 1-phosphatase activity(GO:0052829) inositol-1,3,4,6-tetrakisphosphate 6-phosphatase activity(GO:0052830) inositol-1,3,4,6-tetrakisphosphate 1-phosphatase activity(GO:0052831) phosphatidylinositol-1,4,5-trisphosphate 5-phosphatase activity(GO:0052867) IDP phosphatase activity(GO:1990003)
0.0	0.1	GO:0002060	purine nucleobase binding(GO:0002060)
0.0	0.1	GO:0052760	4-methyloctanoyl-CoA dehydrogenase activity(GO:0034580) naphthyl-2-methyl-succinyl-CoA dehydrogenase activity(GO:0034845) 2-methylhexanoyl-CoA dehydrogenase activity(GO:0034916) propionyl-CoA dehydrogenase activity(GO:0043820) thiol-driven fumarate reductase activity(GO:0043830) coenzyme F420-dependent 2,4,6-trinitrophenol reductase activity(GO:0052758) coenzyme F420-dependent 2,4,6-trinitrophenol hydride reductase activity(GO:0052759) coenzyme F420-dependent 2,4-dinitrophenol reductase activity(GO:0052760)
0.0	0.2	GO:0031995	insulin-like growth factor II binding(GO:0031995)
0.0	0.1	GO:0004367	glycerol-3-phosphate dehydrogenase [NAD+] activity(GO:0004367)
0.0	0.1	GO:0050816	phosphothreonine binding(GO:0050816)
0.0	0.1	GO:0051371	muscle alpha-actinin binding(GO:0051371)
0.0	0.1	GO:0015288	porin activity(GO:0015288)
0.0	0.1	GO:0004719	protein-L-isoaspartate (D-aspartate) O-methyltransferase activity(GO:0004719)
0.0	0.1	GO:0032142	single guanine insertion binding(GO:0032142)
0.0	0.2	GO:0043024	ribosomal small subunit binding(GO:0043024)
0.0	0.1	GO:0051434	BH3 domain binding(GO:0051434)
0.0	0.4	GO:0044105	C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity(GO:0000252) mevaldate reductase activity(GO:0004495) gluconate dehydrogenase activity(GO:0008875) epoxide dehydrogenase activity(GO:0018451) 5-exo-hydroxycamphor dehydrogenase activity(GO:0018452) 2-hydroxytetrahydrofuran dehydrogenase activity(GO:0018453) acetoin dehydrogenase activity(GO:0019152) phenylcoumaran benzylic ether reductase activity(GO:0032442) D-xylose:NADP reductase activity(GO:0032866) L-arabinose:NADP reductase activity(GO:0032867) D-arabinitol dehydrogenase, D-ribulose forming (NADP+) activity(GO:0033709) (R)-(-)-1,2,3,4-tetrahydronaphthol dehydrogenase activity(GO:0034831) 3-hydroxymenthone dehydrogenase activity(GO:0034840) very long-chain-3-hydroxyacyl-CoA dehydrogenase activity(GO:0035380) (R)-2-hydroxyisocaproate dehydrogenase activity(GO:0043713) L-arabinose 1-dehydrogenase (NADP+) activity(GO:0044103) L-xylulose reductase (NAD+) activity(GO:0044105) 3-ketoglucose-reductase activity(GO:0048258) D-arabinitol dehydrogenase, D-xylulose forming (NADP+) activity(GO:0052677)
0.0	0.1	GO:0032051	clathrin light chain binding(GO:0032051)
0.0	0.2	GO:0017160	Ral GTPase binding(GO:0017160)
0.0	0.1	GO:0045503	dynein light chain binding(GO:0045503)
0.0	0.1	GO:0051733	ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity(GO:0046404) polydeoxyribonucleotide kinase activity(GO:0051733)
0.0	0.1	GO:0003688	DNA replication origin binding(GO:0003688)
0.0	0.1	GO:0102338	fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)
0.0	0.3	GO:0016780	phosphotransferase activity, for other substituted phosphate groups(GO:0016780)
0.0	0.1	GO:0048495	Roundabout binding(GO:0048495)
0.0	0.1	GO:0016892	endoribonuclease activity, producing 3'-phosphomonoesters(GO:0016892)
0.0	0.0	GO:0031800	type 3 metabotropic glutamate receptor binding(GO:0031800)
0.0	0.1	GO:0003836	beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.0	0.0	GO:0051870	methotrexate binding(GO:0051870)
0.0	0.0	GO:0060230	lipoprotein lipase activator activity(GO:0060230)
0.0	0.1	GO:0004468	lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468)
0.0	0.1	GO:0035184	histone threonine kinase activity(GO:0035184)
0.0	0.2	GO:0030676	Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0	0.2	GO:0030169	low-density lipoprotein particle binding(GO:0030169)
0.0	0.1	GO:0070097	delta-catenin binding(GO:0070097)
0.0	0.1	GO:0003841	1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)
0.0	0.1	GO:0047184	1-acylglycerophosphocholine O-acyltransferase activity(GO:0047184)
0.0	0.1	GO:0015198	oligopeptide transporter activity(GO:0015198)
0.0	0.1	GO:0031544	peptidyl-proline 3-dioxygenase activity(GO:0031544)
0.0	0.0	GO:0032405	MutLalpha complex binding(GO:0032405)
0.0	0.1	GO:0015377	cation:chloride symporter activity(GO:0015377)
0.0	0.3	GO:0017075	syntaxin-1 binding(GO:0017075)
0.0	0.0	GO:0051373	FATZ binding(GO:0051373)
0.0	0.0	GO:0000340	RNA 7-methylguanosine cap binding(GO:0000340)
0.0	0.0	GO:0016971	flavin-linked sulfhydryl oxidase activity(GO:0016971)
0.0	0.0	GO:0004829	threonine-tRNA ligase activity(GO:0004829)
0.0	0.1	GO:0015016	[heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.0	0.2	GO:0008143	poly(A) binding(GO:0008143)
0.0	0.1	GO:0002162	dystroglycan binding(GO:0002162)
0.0	0.1	GO:0016421	CoA carboxylase activity(GO:0016421)
0.0	0.0	GO:0005247	voltage-gated chloride channel activity(GO:0005247)
0.0	0.0	GO:0030297	transmembrane receptor protein tyrosine kinase activator activity(GO:0030297)
0.0	0.2	GO:0005003	ephrin receptor activity(GO:0005003)
0.0	0.1	GO:0000900	translation repressor activity, nucleic acid binding(GO:0000900)
0.0	0.1	GO:0048406	nerve growth factor binding(GO:0048406)
0.0	0.0	GO:0042296	ISG15 transferase activity(GO:0042296)
0.0	0.0	GO:0004416	hydroxyacylglutathione hydrolase activity(GO:0004416)
0.0	0.1	GO:0005542	folic acid binding(GO:0005542)
0.0	0.1	GO:0031404	chloride ion binding(GO:0031404)
0.0	0.2	GO:0008139	nuclear localization sequence binding(GO:0008139)
0.0	0.9	GO:0004540	ribonuclease activity(GO:0004540)
0.0	0.3	GO:0042165	neurotransmitter binding(GO:0042165)
0.0	0.0	GO:0019198	transmembrane receptor protein phosphatase activity(GO:0019198)
0.0	0.2	GO:0022829	wide pore channel activity(GO:0022829)
0.0	0.0	GO:0097109	neuroligin family protein binding(GO:0097109)
0.0	0.0	GO:0030943	mitochondrion targeting sequence binding(GO:0030943)
0.0	0.1	GO:0005114	type II transforming growth factor beta receptor binding(GO:0005114)
0.0	0.1	GO:0035473	lipase binding(GO:0035473)
0.0	0.0	GO:0032896	palmitoyl-CoA 9-desaturase activity(GO:0032896)
0.0	0.1	GO:0050649	testosterone 6-beta-hydroxylase activity(GO:0050649)
0.0	0.1	GO:0031005	filamin binding(GO:0031005)
0.0	0.0	GO:0019136	deoxynucleoside kinase activity(GO:0019136)
0.0	0.1	GO:0004668	protein-arginine deiminase activity(GO:0004668)
0.0	0.0	GO:0042289	MHC class II protein binding(GO:0042289)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.2	PID SYNDECAN 2 PATHWAY	Syndecan-2-mediated signaling events
0.0	0.8	SA CASPASE CASCADE	Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.0	0.3	PID IL5 PATHWAY	IL5-mediated signaling events
0.0	0.5	PID ATM PATHWAY	ATM pathway
0.0	0.6	PID PI3KCI AKT PATHWAY	Class I PI3K signaling events mediated by Akt
0.0	0.6	PID FOXM1 PATHWAY	FOXM1 transcription factor network
0.0	0.2	PID SMAD2 3PATHWAY	Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.0	0.2	PID EPHA2 FWD PATHWAY	EPHA2 forward signaling
0.0	0.0	ST JNK MAPK PATHWAY	JNK MAPK Pathway
0.0	0.4	PID EPHB FWD PATHWAY	EPHB forward signaling
0.0	0.2	SA B CELL RECEPTOR COMPLEXES	Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.0	0.1	PID ATF2 PATHWAY	ATF-2 transcription factor network
0.0	0.0	ST WNT CA2 CYCLIC GMP PATHWAY	Wnt/Ca2+/cyclic GMP signaling.
0.0	0.2	PID ARF 3PATHWAY	Arf1 pathway
0.0	0.0	PID EPO PATHWAY	EPO signaling pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	1.4	REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE	Genes involved in Glutamate Neurotransmitter Release Cycle
0.1	0.6	REACTOME MTORC1 MEDIATED SIGNALLING	Genes involved in mTORC1-mediated signalling
0.0	0.7	REACTOME APC CDC20 MEDIATED DEGRADATION OF NEK2A	Genes involved in APC-Cdc20 mediated degradation of Nek2A
0.0	0.2	REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING	Genes involved in Formation of ATP by chemiosmotic coupling
0.0	0.4	REACTOME LYSOSOME VESICLE BIOGENESIS	Genes involved in Lysosome Vesicle Biogenesis
0.0	0.2	REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP	Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.0	0.3	REACTOME METABOLISM OF PORPHYRINS	Genes involved in Metabolism of porphyrins
0.0	0.1	REACTOME BETA DEFENSINS	Genes involved in Beta defensins
0.0	0.2	REACTOME COMMON PATHWAY	Genes involved in Common Pathway
0.0	0.2	REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS	Genes involved in Proteolytic cleavage of SNARE complex proteins
0.0	0.2	REACTOME REGULATION OF KIT SIGNALING	Genes involved in Regulation of KIT signaling
0.0	0.4	REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS	Genes involved in Sphingolipid de novo biosynthesis
0.0	0.3	REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY	Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.0	0.3	REACTOME CGMP EFFECTS	Genes involved in cGMP effects
0.0	0.5	REACTOME TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT	Genes involved in Transport of Mature mRNA Derived from an Intronless Transcript
0.0	0.2	REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS	Genes involved in Cell-extracellular matrix interactions
0.0	0.3	REACTOME SULFUR AMINO ACID METABOLISM	Genes involved in Sulfur amino acid metabolism
0.0	0.1	REACTOME THE NLRP3 INFLAMMASOME	Genes involved in The NLRP3 inflammasome
0.0	0.1	REACTOME REGULATION OF COMPLEMENT CASCADE	Genes involved in Regulation of Complement cascade
0.0	0.3	REACTOME MEIOTIC RECOMBINATION	Genes involved in Meiotic Recombination
0.0	0.0	REACTOME SEMA4D IN SEMAPHORIN SIGNALING	Genes involved in Sema4D in semaphorin signaling
0.0	0.3	REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX	Genes involved in Degradation of the extracellular matrix
0.0	0.2	REACTOME GAP JUNCTION ASSEMBLY	Genes involved in Gap junction assembly