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ENCSR904DTN: DNase-seq of mouse liver in constant darkness

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for Rbpj

Z-value: 1.61

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Transcription factors associated with Rbpj

Gene Symbol	Gene ID	Gene Info
Rbpj Ensembl NCBI MGI UniProt	ENSMUSG00000039191.6	Rbpj

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

Gene	Promoter	Distance	Association probability	Pearson corr. coef.	P-value	Plot
Rbpj	chr5_53656339_53656508	10685	0.236867	0.85	3.4e-02	Click!
Rbpj	chr5_53590620_53590774	226	0.946187	0.83	4.2e-02	Click!
Rbpj	chr5_53469500_53469671	3433	0.255326	0.75	8.8e-02	Click!
Rbpj	chr5_53589239_53589555	817	0.678983	0.71	1.1e-01	Click!
Rbpj	chr5_53444100_53444263	21971	0.165880	0.70	1.2e-01	Click!

Activity of the Rbpj motif across conditions

Conditions sorted by the z-value of the Rbpj motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr18_20989972_20990130	1.02	Rnf138	ring finger protein 138	11290	0.2
chr19_23044990_23045152	0.62	Gm50136	predicted gene, 50136	16383	0.2
chr13_111937084_111937265	0.62	Gm9025	predicted gene 9025	52997	0.09
chr8_123657838_123658224	0.55	Rhou	ras homolog family member U	4102	0.05
chr10_61337817_61337968	0.53	Pald1	phosphatase domain containing, paladin 1	4435	0.15
chr8_117700284_117700470	0.50	Hsd17b2	hydroxysteroid (17-beta) dehydrogenase 2	1527	0.3
chr6_144492068_144492244	0.50	Sox5os2	SRY (sex determining region Y)-box 5, opposite strand 2	10931	0.29
chr4_123427592_123427944	0.49	Gm12924	predicted gene 12924	7849	0.18
chr6_28929316_28929468	0.49	Snd1	staphylococcal nuclease and tudor domain containing 1	49349	0.12
chr1_21305444_21305801	0.49	Gm4956	predicted gene 4956	7310	0.1
chr17_27556354_27556505	0.48	Hmga1	high mobility group AT-hook 1	68	0.51
chr11_58006609_58006789	0.47	Larp1	La ribonucleoprotein domain family, member 1	2365	0.25
chr7_19326476_19326637	0.47	Gm44698	predicted gene 44698	6573	0.07
chr1_136937150_136937320	0.47	Nr5a2	nuclear receptor subfamily 5, group A, member 2	3348	0.29
chr8_36491389_36491571	0.46	Trmt9b	tRNA methyltransferase 9B	2289	0.34
chr2_91264224_91264426	0.44	Arfgap2	ADP-ribosylation factor GTPase activating protein 2	649	0.5
chr1_190076180_190076366	0.44	Gm28172	predicted gene 28172	92397	0.07
chr11_103021982_103022133	0.42	Dcakd	dephospho-CoA kinase domain containing	4889	0.13
chr3_98295816_98295967	0.42	Gm43189	predicted gene 43189	8903	0.15
chr7_6696462_6696626	0.41	Zim1	zinc finger, imprinted 1	94	0.95
chr12_102453656_102453840	0.41	Gm30198	predicted gene, 30198	6420	0.17
chr13_92609818_92609992	0.41	Serinc5	serine incorporator 5	1186	0.52
chr2_128731575_128731758	0.40	Gm14011	predicted gene 14011	22039	0.13
chr10_11615264_11615424	0.39	Gm9797	predicted pseudogene 9797	6046	0.22
chr15_100666435_100666616	0.39	Bin2	bridging integrator 2	2980	0.13
chr6_142708472_142708687	0.39	Abcc9	ATP-binding cassette, sub-family C (CFTR/MRP), member 9	6264	0.22
chr11_70585533_70585714	0.38	Mink1	misshapen-like kinase 1 (zebrafish)	13365	0.07
chr17_31871058_31871230	0.38	Sik1	salt inducible kinase 1	15340	0.14
chr8_70219826_70219982	0.38	Armc6	armadillo repeat containing 6	2386	0.16
chr19_42601924_42602199	0.37	Loxl4	lysyl oxidase-like 4	1260	0.45
chr1_106189902_106190053	0.37	Phlpp1	PH domain and leucine rich repeat protein phosphatase 1	18225	0.16
chr1_193270900_193271248	0.36	G0s2	G0/G1 switch gene 2	2143	0.16
chr4_54874667_54875024	0.36	Gm12479	predicted gene 12479	21717	0.23
chr7_100908136_100908439	0.36	Arhgef17	Rho guanine nucleotide exchange factor (GEF) 17	13597	0.13
chr1_157012797_157012985	0.36	Gm10531	predicted gene 10531	30656	0.14
chr2_154613231_154613406	0.36	Zfp341	zinc finger protein 341	21	0.6
chr9_102864196_102864634	0.36	Ryk	receptor-like tyrosine kinase	4651	0.18
chr4_86664611_86664778	0.36	Plin2	perilipin 2	1031	0.52
chr9_21032221_21032372	0.35	Mir1900	microRNA 1900	32	0.44
chr8_120244102_120244267	0.35	Gse1	genetic suppressor element 1, coiled-coil protein	15728	0.17
chr2_31135715_31135955	0.35	Fnbp1	formin binding protein 1	5967	0.16
chr17_80061203_80061420	0.35	Hnrnpll	heterogeneous nuclear ribonucleoprotein L-like	824	0.55
chr2_38379077_38379228	0.35	Gm13584	predicted gene 13584	15172	0.14
chr8_11002584_11002773	0.35	9530052E02Rik	RIKEN cDNA 9530052E02 gene	5172	0.14
chr8_83582345_83582520	0.34	Gm45823	predicted gene 45823	3093	0.12
chr6_36280777_36280955	0.34	9330158H04Rik	RIKEN cDNA 9330158H04 gene	6510	0.29
chr5_112294789_112294953	0.34	Tpst2	protein-tyrosine sulfotransferase 2	6109	0.12
chr8_117357893_117358044	0.34	Cmip	c-Maf inducing protein	8798	0.25
chr8_93959067_93959388	0.34	Gnao1	guanine nucleotide binding protein, alpha O	3617	0.19
chr15_102181335_102181499	0.34	Csad	cysteine sulfinic acid decarboxylase	1556	0.24
chr16_37431973_37432137	0.34	Stxbp5l	syntaxin binding protein 5-like	47093	0.13
chr4_148147807_148147968	0.34	Mir7022	microRNA 7022	891	0.36
chr8_13038384_13038564	0.33	F10	coagulation factor X	636	0.54
chr9_65036564_65036722	0.33	Dpp8	dipeptidylpeptidase 8	3865	0.18
chr18_69690243_69690422	0.33	Tcf4	transcription factor 4	7952	0.3
chr13_63929441_63929609	0.33	Gm7695	predicted gene 7695	16996	0.18
chr4_7143814_7143981	0.32	Gm11804	predicted gene 11804	104383	0.08
chr2_44114387_44114618	0.32	Arhgap15os	Rho GTPase activating protein 15, opposite strand	49178	0.17
chr14_79514360_79514523	0.32	Elf1	E74-like factor 1	1233	0.43
chr7_68606375_68606542	0.32	Gm44887	predicted gene 44887	7604	0.22
chr5_121400646_121400949	0.32	Gm43420	predicted gene 43420	1861	0.18
chr18_80237311_80237611	0.31	Hsbp1l1	heat shock factor binding protein 1-like 1	628	0.57
chr13_38086772_38086930	0.31	Gm27387	predicted gene, 27387	649	0.69
chr5_142440070_142440526	0.31	Ap5z1	adaptor-related protein complex 5, zeta 1 subunit	23646	0.17
chr1_51909329_51909480	0.31	Myo1b	myosin IB	2088	0.24
chr15_25942169_25942359	0.31	Retreg1	reticulophagy regulator 1	415	0.85
chr5_126954306_126954487	0.31	Gm42955	predicted gene 42955	65831	0.11
chr6_28896982_28897268	0.31	Snd1	staphylococcal nuclease and tudor domain containing 1	17082	0.2
chr8_83582597_83582758	0.30	Gm45823	predicted gene 45823	2848	0.13
chr9_123492299_123492489	0.30	Limd1	LIM domains containing 1	11784	0.17
chr3_145592253_145592420	0.30	Znhit6	zinc finger, HIT type 6	3532	0.25
chr11_45877552_45877727	0.30	Clint1	clathrin interactor 1	4758	0.18
chr11_114867107_114867285	0.30	Gprc5c	G protein-coupled receptor, family C, group 5, member C	2704	0.19
chr2_61474961_61475340	0.30	Gm22338	predicted gene, 22338	17616	0.26
chr5_72763116_72763280	0.29	Txk	TXK tyrosine kinase	10421	0.15
chr17_5295996_5296161	0.29	Gm29050	predicted gene 29050	92685	0.08
chr15_7070249_7070660	0.29	Lifr	LIF receptor alpha	20160	0.25
chr17_27817796_27817959	0.29	Ilrun	inflammation and lipid regulator with UBA-like and NBR1-like domains	2575	0.18
chr7_16047828_16047993	0.28	Bicra	BRD4 interacting chromatin remodeling complex associated protein	11	0.97
chr6_31263686_31264023	0.28	2210408F21Rik	RIKEN cDNA 2210408F21 gene	13994	0.16
chr8_93332780_93333003	0.28	Ces1g	carboxylesterase 1G	4417	0.17
chr7_6343656_6343820	0.28	Gm3854	predicted gene 3854	21	0.77
chr11_4661332_4661649	0.28	Ascc2	activating signal cointegrator 1 complex subunit 2	23743	0.12
chr6_114866683_114866890	0.28	Vgll4	vestigial like family member 4	2029	0.33
chr15_100625350_100625569	0.28	Dazap2	DAZ associated protein 2	9127	0.08
chr18_36713491_36713783	0.28	Cd14	CD14 antigen	13101	0.07
chr19_4719341_4719664	0.27	Sptbn2	spectrin beta, non-erythrocytic 2	1577	0.24
chr5_93250297_93250457	0.27	Ccng2	cyclin G2	16880	0.14
chr7_127967101_127967258	0.27	Fus	fused in sarcoma	278	0.77
chr2_133552164_133552315	0.27	Bmp2	bone morphogenetic protein 2	80	0.97
chr2_93775482_93775671	0.27	Gm13818	predicted gene 13818	18994	0.17
chr19_6991850_6992452	0.27	Dnajc4	DnaJ heat shock protein family (Hsp40) member C4	121	0.89
chr7_112237962_112238160	0.27	Mical2	microtubule associated monooxygenase, calponin and LIM domain containing 2	12171	0.27
chr9_115481085_115481255	0.27	Gm5921	predicted gene 5921	42589	0.13
chr4_134488308_134488479	0.26	Gm13250	predicted gene 13250	4829	0.11
chr11_29613290_29613486	0.26	Gm12091	predicted gene 12091	10775	0.13
chr17_86539829_86540339	0.26	Gm10309	predicted gene 10309	34852	0.18
chr5_146974799_146974984	0.26	Mtif3	mitochondrial translational initiation factor 3	11091	0.17
chr6_124694855_124695031	0.26	Lpcat3	lysophosphatidylcholine acyltransferase 3	6476	0.07
chr5_65349405_65349570	0.26	Klb	klotho beta	1079	0.38
chr14_100284919_100285099	0.26	Klf12	Kruppel-like factor 12	330	0.83
chrX_37085164_37085323	0.26	Rpl39	ribosomal protein L39	77	0.94
chr12_111443408_111443817	0.26	Tnfaip2	tumor necrosis factor, alpha-induced protein 2	712	0.55
chr11_7536835_7536986	0.26	Gm11986	predicted gene 11986	246536	0.02
chr2_90503158_90503454	0.26	4933423P22Rik	RIKEN cDNA 4933423P22 gene	24056	0.16
chr9_10340859_10341010	0.25	Gm25086	predicted gene, 25086	45778	0.15
chr10_66933753_66933946	0.25	Gm26576	predicted gene, 26576	13547	0.16
chr14_30906121_30906307	0.25	Itih4	inter alpha-trypsin inhibitor, heavy chain 4	7053	0.11
chr19_7090027_7090210	0.25	AC109619.1	novel transcript, antisense to Macrod1	1697	0.24
chr19_21914078_21914469	0.25	Ldhb-ps	lactate dehydrogenase B, pseudogene	23107	0.18
chr5_117985838_117985989	0.25	Fbxo21	F-box protein 21	6589	0.15
chr17_34586879_34587070	0.25	Notch4	notch 4	29	0.91
chr1_164435096_164435776	0.25	Atp1b1	ATPase, Na+/K+ transporting, beta 1 polypeptide	8283	0.15
chr16_77360217_77360390	0.25	Gm37466	predicted gene, 37466	21647	0.13
chr10_93161593_93161779	0.25	Cdk17	cyclin-dependent kinase 17	796	0.5
chrX_16815855_16816045	0.25	Maob	monoamine oxidase B	1325	0.59
chr12_85785184_85785363	0.24	Flvcr2	feline leukemia virus subgroup C cellular receptor 2	10443	0.16
chr5_35751138_35751297	0.24	Ablim2	actin-binding LIM protein 2	6663	0.18
chr5_130256839_130256998	0.24	Tyw1	tRNA-yW synthesizing protein 1 homolog (S. cerevisiae)	117	0.93
chr16_90143819_90143995	0.24	Tiam1	T cell lymphoma invasion and metastasis 1	138	0.96
chr14_59505972_59506134	0.24	Cab39l	calcium binding protein 39-like	27237	0.17
chr7_25238448_25238634	0.24	Gsk3a	glycogen synthase kinase 3 alpha	690	0.45
chr11_63851241_63851480	0.24	Hmgb1-ps3	high mobility group box 1, pseudogene 3	4542	0.26
chr10_62216958_62217109	0.24	Tspan15	tetraspanin 15	14218	0.15
chr7_131556667_131556855	0.24	Hmx2	H6 homeobox 2	2700	0.19
chr4_109140391_109140554	0.24	Osbpl9	oxysterol binding protein-like 9	16138	0.21
chr17_46995065_46995238	0.24	Ubr2	ubiquitin protein ligase E3 component n-recognin 2	15328	0.16
chr9_66795028_66795465	0.24	Aph1b	aph1 homolog B, gamma secretase subunit	130	0.93
chr8_88863392_88863746	0.24	Gm45504	predicted gene 45504	495	0.85
chr19_36834098_36834270	0.24	Tnks2	tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2	48	0.98
chr9_88438974_88439140	0.24	Snx14	sorting nexin 14	99	0.95
chr7_44670891_44671049	0.24	Myh14	myosin, heavy polypeptide 14	127	0.92
chr1_119661376_119661532	0.24	Epb41l5	erythrocyte membrane protein band 4.1 like 5	12454	0.16
chr8_126736201_126736366	0.24	Gm45805	predicted gene 45805	22051	0.23
chr1_21232096_21232271	0.23	Gm38224	predicted gene, 38224	2539	0.18
chr10_125354951_125355118	0.23	Slc16a7	solute carrier family 16 (monocarboxylic acid transporters), member 7	12855	0.22
chr19_53140710_53140861	0.23	Add3	adducin 3 (gamma)	268	0.88
chr8_60890550_60890715	0.23	Hpf1	histone PARylation factor 1	143	0.96
chr11_113725569_113725747	0.23	Cdc42ep4	CDC42 effector protein (Rho GTPase binding) 4	13664	0.13
chr16_23978554_23978740	0.23	Bcl6	B cell leukemia/lymphoma 6	6267	0.18
chr6_88743999_88744163	0.23	Gm43999	predicted gene, 43999	1354	0.31
chr5_122526542_122526845	0.23	Gm22965	predicted gene, 22965	19904	0.09
chr11_28584268_28584419	0.23	Ccdc85a	coiled-coil domain containing 85A	19	0.99
chr8_8994570_8994800	0.23	Gm44515	predicted gene 44515	61986	0.12
chr9_77753424_77753607	0.23	Gclc	glutamate-cysteine ligase, catalytic subunit	1020	0.45
chr11_86916528_86916698	0.23	Ypel2	yippee like 2	55411	0.11
chr19_10073210_10073809	0.23	Fads2	fatty acid desaturase 2	2322	0.22
chr8_25793840_25794009	0.23	Lsm1	LSM1 homolog, mRNA degradation associated	8337	0.1
chr2_12148001_12148165	0.22	Itga8	integrin alpha 8	15531	0.2
chr14_76152803_76153117	0.22	Nufip1	nuclear fragile X mental retardation protein interacting protein 1	42069	0.14
chr15_10248990_10249545	0.22	Prlr	prolactin receptor	293	0.94
chr10_59475055_59475224	0.22	Mcu	mitochondrial calcium uniporter	16979	0.18
chr2_164785184_164785412	0.22	Snx21	sorting nexin family member 21	525	0.53
chr9_69323922_69324079	0.22	Rora	RAR-related orphan receptor alpha	34318	0.15
chr10_20104280_20104431	0.22	Map3k5	mitogen-activated protein kinase kinase kinase 5	4830	0.24
chr16_30065187_30065349	0.22	Hes1	hes family bHLH transcription factor 1	72	0.97
chrX_12135920_12136079	0.22	Bcor	BCL6 interacting corepressor	7599	0.26
chr2_59726132_59726380	0.22	Tanc1	tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1	16546	0.26
chr5_144333150_144333429	0.22	Dmrt1i	Dmrt1 interacting ncRNA	24634	0.13
chr19_40464469_40464658	0.22	Sorbs1	sorbin and SH3 domain containing 1	13173	0.21
chr4_11861590_11861758	0.22	Gm25002	predicted gene, 25002	87213	0.07
chr6_35253418_35253775	0.22	1810058I24Rik	RIKEN cDNA 1810058I24 gene	864	0.54
chr11_17258171_17258606	0.22	C1d	C1D nuclear receptor co-repressor	700	0.69
chr4_95141392_95141560	0.21	Gm28096	predicted gene 28096	10264	0.16
chr11_109485510_109486095	0.21	Arsg	arylsulfatase G	196	0.91
chr11_115824988_115825141	0.21	Llgl2	LLGL2 scribble cell polarity complex component	1006	0.35
chr5_43869261_43869583	0.21	Cd38	CD38 antigen	562	0.61
chr10_25595963_25596295	0.21	Gm36908	predicted gene, 36908	25434	0.15
chr6_57506758_57506926	0.21	Ppm1k	protein phosphatase 1K (PP2C domain containing)	8765	0.14
chr19_47337853_47338021	0.21	Sh3pxd2a	SH3 and PX domains 2A	23186	0.17
chr12_28623362_28623536	0.21	Colec11	collectin sub-family member 11	72	0.96
chr8_119417171_119417322	0.21	Osgin1	oxidative stress induced growth inhibitor 1	16878	0.13
chr4_126181292_126181458	0.21	Thrap3	thyroid hormone receptor associated protein 3	1228	0.32
chr8_82689441_82689600	0.21	Gm9655	predicted gene 9655	58096	0.13
chr4_82406927_82407107	0.21	n-R5s188	nuclear encoded rRNA 5S 188	32393	0.21
chr2_126373873_126374024	0.21	Atp8b4	ATPase, class I, type 8B, member 4	117605	0.05
chr15_78450182_78450345	0.21	Tmprss6	transmembrane serine protease 6	5884	0.11
chr16_33062247_33062405	0.21	Lmln	leishmanolysin-like (metallopeptidase M8 family)	195	0.9
chr4_125065950_125066101	0.21	Dnali1	dynein, axonemal, light intermediate polypeptide 1	322	0.66
chr4_128621016_128621181	0.21	Tlr12	toll-like receptor 12	2479	0.24
chr10_81326957_81327144	0.21	Tbxa2r	thromboxane A2 receptor	1681	0.13
chr13_74166717_74166944	0.21	Exoc3	exocyst complex component 3	7617	0.19
chr11_75190453_75190617	0.21	Dph1	diphthamide biosynthesis 1	16	0.95
chr1_73188866_73189036	0.21	Gm38106	predicted gene, 38106	20472	0.23
chr11_58914378_58914796	0.21	Btnl10	butyrophilin-like 10	3321	0.09
chr10_99215027_99215178	0.20	Gm34574	predicted gene, 34574	7964	0.12
chr7_112353137_112353298	0.20	Mical2	microtubule associated monooxygenase, calponin and LIM domain containing 2	3823	0.33
chr17_10237978_10238400	0.20	Qk	quaking	24615	0.24
chr5_8961694_8961940	0.20	Abcb4	ATP-binding cassette, sub-family B (MDR/TAP), member 4	3265	0.17
chr6_13871418_13871584	0.20	2610001J05Rik	RIKEN cDNA 2610001J05 gene	17	0.5
chr5_150195920_150196236	0.20	Fry	FRY microtubule binding protein	388	0.88
chr11_19920515_19920734	0.20	Spred2	sprouty-related EVH1 domain containing 2	3751	0.33
chr17_12415417_12415751	0.20	Plg	plasminogen	36925	0.12
chr17_85037271_85037422	0.20	Slc3a1	solute carrier family 3, member 1	8970	0.19
chr3_115635601_115635754	0.20	S1pr1	sphingosine-1-phosphate receptor 1	79395	0.09
chr2_34154899_34155111	0.20	Gm38389	predicted gene, 38389	43561	0.15
chr15_76722928_76723137	0.20	C030006K11Rik	RIKEN cDNA C030006K11 gene	353	0.62
chr19_40630689_40630866	0.20	Gm8783	predicted pseudogene 8783	8317	0.12
chr17_12402018_12402192	0.20	Plg	plasminogen	23446	0.15
chr1_52113713_52114086	0.20	Gm31812	predicted gene, 31812	148	0.93

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of Rbpj

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:0003134	BMP signaling pathway involved in heart induction(GO:0003130) endodermal-mesodermal cell signaling(GO:0003133) endodermal-mesodermal cell signaling involved in heart induction(GO:0003134)
0.1	0.3	GO:0010792	DNA double-strand break processing involved in repair via single-strand annealing(GO:0010792)
0.1	0.2	GO:1904217	regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity(GO:1904217) positive regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity(GO:1904219) regulation of serine C-palmitoyltransferase activity(GO:1904220) positive regulation of serine C-palmitoyltransferase activity(GO:1904222)
0.1	0.2	GO:0071879	positive regulation of adrenergic receptor signaling pathway(GO:0071879)
0.1	0.2	GO:1990791	dorsal root ganglion development(GO:1990791)
0.1	0.2	GO:0010735	positive regulation of transcription via serum response element binding(GO:0010735)
0.1	0.2	GO:1903849	regulation of aorta morphogenesis(GO:1903847) positive regulation of aorta morphogenesis(GO:1903849)
0.1	0.2	GO:0045897	regulation of transcription during mitosis(GO:0045896) positive regulation of transcription during mitosis(GO:0045897)
0.1	0.2	GO:0061113	pancreas morphogenesis(GO:0061113)
0.1	0.2	GO:1903977	positive regulation of glial cell migration(GO:1903977)
0.1	0.3	GO:0038161	prolactin signaling pathway(GO:0038161)
0.1	0.2	GO:0070213	protein auto-ADP-ribosylation(GO:0070213)
0.1	0.2	GO:0016344	meiotic chromosome movement towards spindle pole(GO:0016344)
0.0	0.2	GO:0090168	Golgi reassembly(GO:0090168)
0.0	0.2	GO:0017182	peptidyl-diphthamide metabolic process(GO:0017182) peptidyl-diphthamide biosynthetic process from peptidyl-histidine(GO:0017183)
0.0	0.1	GO:0021699	cerebellar cortex maturation(GO:0021699)
0.0	0.1	GO:0006701	progesterone biosynthetic process(GO:0006701)
0.0	0.2	GO:2000504	positive regulation of blood vessel remodeling(GO:2000504)
0.0	0.2	GO:0051562	negative regulation of mitochondrial calcium ion concentration(GO:0051562)
0.0	0.1	GO:0045472	response to ether(GO:0045472)
0.0	0.1	GO:2000974	negative regulation of pro-B cell differentiation(GO:2000974)
0.0	0.1	GO:0010510	regulation of acetyl-CoA biosynthetic process from pyruvate(GO:0010510)
0.0	0.1	GO:0018197	peptidyl-aspartic acid modification(GO:0018197)
0.0	0.1	GO:0006566	threonine metabolic process(GO:0006566)
0.0	0.1	GO:0019448	cysteine catabolic process(GO:0009093) L-cysteine catabolic process(GO:0019448) L-cysteine metabolic process(GO:0046439)
0.0	0.1	GO:0032907	transforming growth factor beta3 production(GO:0032907) regulation of transforming growth factor beta3 production(GO:0032910)
0.0	0.2	GO:0051409	response to nitrosative stress(GO:0051409)
0.0	0.2	GO:0014063	negative regulation of serotonin secretion(GO:0014063)
0.0	0.2	GO:0009115	xanthine catabolic process(GO:0009115)
0.0	0.1	GO:0032483	regulation of Rab protein signal transduction(GO:0032483)
0.0	0.1	GO:1901679	nucleotide transmembrane transport(GO:1901679)
0.0	0.1	GO:0042138	meiotic DNA double-strand break formation(GO:0042138)
0.0	0.1	GO:1900825	regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900825)
0.0	0.1	GO:0009240	isopentenyl diphosphate biosynthetic process(GO:0009240) isopentenyl diphosphate biosynthetic process, mevalonate pathway(GO:0019287)
0.0	0.1	GO:1902809	regulation of skeletal muscle fiber differentiation(GO:1902809)
0.0	0.1	GO:1903689	regulation of wound healing, spreading of epidermal cells(GO:1903689)
0.0	0.1	GO:0065001	specification of axis polarity(GO:0065001)
0.0	0.2	GO:0006104	succinyl-CoA metabolic process(GO:0006104)
0.0	0.2	GO:0019673	GDP-mannose metabolic process(GO:0019673)
0.0	0.2	GO:0006561	proline biosynthetic process(GO:0006561)
0.0	0.1	GO:0030242	pexophagy(GO:0030242)
0.0	0.1	GO:0006741	NADP biosynthetic process(GO:0006741)
0.0	0.2	GO:0048597	post-embryonic camera-type eye morphogenesis(GO:0048597)
0.0	0.2	GO:0090527	actin filament reorganization(GO:0090527)
0.0	0.1	GO:0036444	calcium ion transmembrane import into mitochondrion(GO:0036444)
0.0	0.1	GO:0035928	rRNA import into mitochondrion(GO:0035928)
0.0	0.0	GO:0000720	pyrimidine dimer repair by nucleotide-excision repair(GO:0000720)
0.0	0.1	GO:0000491	small nucleolar ribonucleoprotein complex assembly(GO:0000491) box C/D snoRNP assembly(GO:0000492)
0.0	0.1	GO:1901509	regulation of endothelial tube morphogenesis(GO:1901509)
0.0	0.2	GO:0061158	3'-UTR-mediated mRNA destabilization(GO:0061158)
0.0	0.2	GO:0002227	innate immune response in mucosa(GO:0002227)
0.0	0.1	GO:0010529	regulation of transposition(GO:0010528) negative regulation of transposition(GO:0010529)
0.0	0.1	GO:0010360	negative regulation of anion channel activity(GO:0010360)
0.0	0.1	GO:2000619	negative regulation of histone H4-K16 acetylation(GO:2000619)
0.0	0.1	GO:0043133	hindgut contraction(GO:0043133) regulation of hindgut contraction(GO:0043134)
0.0	0.1	GO:0048496	maintenance of organ identity(GO:0048496)
0.0	0.0	GO:0007571	age-dependent response to oxidative stress(GO:0001306) age-dependent general metabolic decline(GO:0007571)
0.0	0.1	GO:2001199	negative regulation of dendritic cell differentiation(GO:2001199)
0.0	0.0	GO:2001198	regulation of dendritic cell differentiation(GO:2001198)
0.0	0.2	GO:0034498	early endosome to Golgi transport(GO:0034498)
0.0	0.1	GO:0070317	negative regulation of G0 to G1 transition(GO:0070317)
0.0	0.1	GO:1902459	positive regulation of stem cell population maintenance(GO:1902459)
0.0	0.1	GO:0061643	chemorepulsion of axon(GO:0061643)
0.0	0.0	GO:0033668	negative regulation by symbiont of host apoptotic process(GO:0033668) negative regulation by symbiont of host programmed cell death(GO:0052041) negative regulation by organism of programmed cell death in other organism involved in symbiotic interaction(GO:0052490)
0.0	0.1	GO:0042118	endothelial cell activation(GO:0042118)
0.0	0.0	GO:1901187	regulation of ephrin receptor signaling pathway(GO:1901187)
0.0	0.1	GO:0071225	cellular response to muramyl dipeptide(GO:0071225)
0.0	0.2	GO:0031936	negative regulation of chromatin silencing(GO:0031936)
0.0	0.1	GO:0071316	cellular response to nicotine(GO:0071316)
0.0	0.1	GO:0000395	mRNA 5'-splice site recognition(GO:0000395)
0.0	0.1	GO:0035948	positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter(GO:0035948)
0.0	0.1	GO:0060066	oviduct development(GO:0060066)
0.0	0.1	GO:0019276	UDP-N-acetylgalactosamine metabolic process(GO:0019276)
0.0	0.3	GO:0033194	response to hydroperoxide(GO:0033194)
0.0	0.1	GO:1901668	regulation of superoxide dismutase activity(GO:1901668)
0.0	0.3	GO:0043968	histone H2A acetylation(GO:0043968)
0.0	0.1	GO:0002159	desmosome assembly(GO:0002159)
0.0	0.4	GO:0070584	mitochondrion morphogenesis(GO:0070584)
0.0	0.1	GO:0046951	ketone body biosynthetic process(GO:0046951)
0.0	0.0	GO:0007039	protein catabolic process in the vacuole(GO:0007039)
0.0	0.1	GO:0090271	positive regulation of fibroblast growth factor production(GO:0090271)
0.0	0.1	GO:1901475	pyruvate transmembrane transport(GO:1901475)
0.0	0.1	GO:0032790	ribosome disassembly(GO:0032790)
0.0	0.1	GO:0006624	vacuolar protein processing(GO:0006624)
0.0	0.0	GO:0060331	negative regulation of response to interferon-gamma(GO:0060331) negative regulation of interferon-gamma-mediated signaling pathway(GO:0060336)
0.0	0.1	GO:1902897	regulation of postsynaptic density protein 95 clustering(GO:1902897)
0.0	0.1	GO:0006620	posttranslational protein targeting to membrane(GO:0006620)
0.0	0.1	GO:0090080	positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway(GO:0090080)
0.0	0.0	GO:0032079	positive regulation of endodeoxyribonuclease activity(GO:0032079)
0.0	0.1	GO:0006768	biotin metabolic process(GO:0006768)
0.0	0.1	GO:2001286	regulation of caveolin-mediated endocytosis(GO:2001286)
0.0	0.2	GO:0008535	respiratory chain complex IV assembly(GO:0008535)
0.0	0.1	GO:0090038	negative regulation of protein kinase C signaling(GO:0090038)
0.0	0.1	GO:0045917	positive regulation of complement activation(GO:0045917) positive regulation of protein activation cascade(GO:2000259)
0.0	0.2	GO:0006527	arginine catabolic process(GO:0006527)
0.0	0.0	GO:2000418	positive regulation of eosinophil migration(GO:2000418)
0.0	0.0	GO:0042726	flavin-containing compound metabolic process(GO:0042726)
0.0	0.1	GO:0030422	production of siRNA involved in RNA interference(GO:0030422)
0.0	0.0	GO:0043307	eosinophil activation involved in immune response(GO:0002278) eosinophil mediated immunity(GO:0002447) eosinophil activation(GO:0043307) eosinophil degranulation(GO:0043308)
0.0	0.1	GO:0003241	growth involved in heart morphogenesis(GO:0003241)
0.0	0.0	GO:0010248	establishment or maintenance of transmembrane electrochemical gradient(GO:0010248)
0.0	0.0	GO:0051151	negative regulation of smooth muscle cell differentiation(GO:0051151)
0.0	0.1	GO:0070389	chaperone cofactor-dependent protein refolding(GO:0070389)
0.0	0.1	GO:0052805	histidine catabolic process(GO:0006548) imidazole-containing compound catabolic process(GO:0052805)
0.0	0.1	GO:0071712	ER-associated misfolded protein catabolic process(GO:0071712)
0.0	0.1	GO:0072675	osteoclast fusion(GO:0072675)
0.0	0.0	GO:0006419	alanyl-tRNA aminoacylation(GO:0006419)
0.0	0.1	GO:0000711	meiotic DNA repair synthesis(GO:0000711)
0.0	0.0	GO:0039534	negative regulation of MDA-5 signaling pathway(GO:0039534)
0.0	0.2	GO:0001731	formation of translation preinitiation complex(GO:0001731)
0.0	0.1	GO:0006551	leucine metabolic process(GO:0006551)
0.0	0.3	GO:0048026	positive regulation of mRNA splicing, via spliceosome(GO:0048026)
0.0	0.2	GO:0051601	exocyst localization(GO:0051601)
0.0	0.1	GO:2000467	positive regulation of glycogen (starch) synthase activity(GO:2000467)
0.0	0.1	GO:1904707	positive regulation of vascular smooth muscle cell proliferation(GO:1904707)
0.0	0.0	GO:0045626	negative regulation of T-helper 1 cell differentiation(GO:0045626)
0.0	0.2	GO:0046415	urate metabolic process(GO:0046415)
0.0	0.1	GO:0002525	acute inflammatory response to non-antigenic stimulus(GO:0002525)
0.0	0.0	GO:1904469	positive regulation of tumor necrosis factor secretion(GO:1904469)
0.0	0.1	GO:0097264	self proteolysis(GO:0097264)
0.0	0.2	GO:0051895	negative regulation of focal adhesion assembly(GO:0051895)
0.0	0.0	GO:1903587	regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:1903587)
0.0	0.0	GO:1902564	negative regulation of neutrophil activation(GO:1902564)
0.0	0.0	GO:0007227	signal transduction downstream of smoothened(GO:0007227)
0.0	0.1	GO:0006398	mRNA 3'-end processing by stem-loop binding and cleavage(GO:0006398)
0.0	0.1	GO:0009838	abscission(GO:0009838)
0.0	0.0	GO:2000721	positive regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation(GO:2000721)
0.0	0.0	GO:0010748	negative regulation of plasma membrane long-chain fatty acid transport(GO:0010748)
0.0	0.0	GO:0072385	minus-end-directed organelle transport along microtubule(GO:0072385)
0.0	0.1	GO:0052405	negative regulation by host of symbiont molecular function(GO:0052405) modification by host of symbiont molecular function(GO:0052428)
0.0	0.1	GO:0006931	substrate-dependent cell migration, cell attachment to substrate(GO:0006931)
0.0	0.1	GO:0006681	galactosylceramide metabolic process(GO:0006681)
0.0	0.1	GO:0046726	positive regulation by virus of viral protein levels in host cell(GO:0046726)
0.0	0.1	GO:0009235	cobalamin metabolic process(GO:0009235)
0.0	0.0	GO:0010911	regulation of isomerase activity(GO:0010911) positive regulation of isomerase activity(GO:0010912)
0.0	0.1	GO:0070050	neuron cellular homeostasis(GO:0070050)
0.0	0.0	GO:0002309	T cell proliferation involved in immune response(GO:0002309)
0.0	0.1	GO:0072378	blood coagulation, fibrin clot formation(GO:0072378)
0.0	0.0	GO:0060375	regulation of mast cell differentiation(GO:0060375)
0.0	0.0	GO:0046208	spermine catabolic process(GO:0046208)
0.0	0.1	GO:0006787	porphyrin-containing compound catabolic process(GO:0006787) tetrapyrrole catabolic process(GO:0033015)
0.0	0.0	GO:0039530	MDA-5 signaling pathway(GO:0039530)
0.0	0.0	GO:2000705	regulation of dense core granule biogenesis(GO:2000705)
0.0	0.0	GO:0072205	metanephric collecting duct development(GO:0072205)
0.0	0.0	GO:0006868	glutamine transport(GO:0006868)
0.0	0.1	GO:0090166	Golgi disassembly(GO:0090166)
0.0	0.0	GO:1900748	positive regulation of vascular endothelial growth factor signaling pathway(GO:1900748)
0.0	0.1	GO:0034773	histone H4-K20 trimethylation(GO:0034773)
0.0	0.0	GO:0071233	response to leucine(GO:0043201) cellular response to leucine(GO:0071233)
0.0	0.1	GO:0016199	axon midline choice point recognition(GO:0016199)
0.0	0.0	GO:2000065	negative regulation of aldosterone metabolic process(GO:0032345) negative regulation of aldosterone biosynthetic process(GO:0032348) negative regulation of cortisol biosynthetic process(GO:2000065)
0.0	0.1	GO:0043456	regulation of pentose-phosphate shunt(GO:0043456)
0.0	0.0	GO:0035106	operant conditioning(GO:0035106)
0.0	0.1	GO:0034154	toll-like receptor 7 signaling pathway(GO:0034154)
0.0	0.1	GO:0071830	chylomicron remnant clearance(GO:0034382) triglyceride-rich lipoprotein particle clearance(GO:0071830)
0.0	0.2	GO:0033120	positive regulation of RNA splicing(GO:0033120)
0.0	0.0	GO:2000670	positive regulation of dendritic cell apoptotic process(GO:2000670)
0.0	0.0	GO:0019042	viral latency(GO:0019042)
0.0	0.1	GO:1902036	regulation of hematopoietic stem cell differentiation(GO:1902036)
0.0	0.0	GO:0048677	axon extension involved in regeneration(GO:0048677) sprouting of injured axon(GO:0048682)
0.0	0.0	GO:0006553	lysine metabolic process(GO:0006553)
0.0	0.0	GO:0060414	aorta smooth muscle tissue morphogenesis(GO:0060414)
0.0	0.0	GO:0071332	response to fructose(GO:0009750) cellular response to fructose stimulus(GO:0071332)
0.0	0.0	GO:0090365	regulation of mRNA modification(GO:0090365)
0.0	0.0	GO:0072137	condensed mesenchymal cell proliferation(GO:0072137)
0.0	0.0	GO:1903279	regulation of calcium:sodium antiporter activity(GO:1903279)
0.0	0.1	GO:0007095	mitotic G2 DNA damage checkpoint(GO:0007095)
0.0	0.0	GO:0070309	lens fiber cell morphogenesis(GO:0070309)
0.0	0.1	GO:0034227	tRNA thio-modification(GO:0034227)
0.0	0.1	GO:0032000	positive regulation of fatty acid beta-oxidation(GO:0032000)
0.0	0.1	GO:0071404	cellular response to low-density lipoprotein particle stimulus(GO:0071404)
0.0	0.0	GO:0000960	mitochondrial RNA catabolic process(GO:0000957) regulation of mitochondrial RNA catabolic process(GO:0000960)
0.0	0.0	GO:0070314	G1 to G0 transition(GO:0070314)
0.0	0.1	GO:1900119	positive regulation of execution phase of apoptosis(GO:1900119)
0.0	0.0	GO:0072307	metanephric nephron tubule epithelial cell differentiation(GO:0072257) regulation of metanephric nephron tubule epithelial cell differentiation(GO:0072307)
0.0	0.1	GO:0006703	estrogen biosynthetic process(GO:0006703)
0.0	0.1	GO:0090073	positive regulation of protein homodimerization activity(GO:0090073)
0.0	0.1	GO:0030174	regulation of DNA-dependent DNA replication initiation(GO:0030174)
0.0	0.0	GO:0006391	transcription initiation from mitochondrial promoter(GO:0006391)
0.0	0.1	GO:0002317	plasma cell differentiation(GO:0002317)
0.0	0.1	GO:0072161	mesenchymal cell differentiation involved in kidney development(GO:0072161) mesenchymal cell differentiation involved in renal system development(GO:2001012)
0.0	0.1	GO:0097119	postsynaptic density protein 95 clustering(GO:0097119)
0.0	0.0	GO:0006556	S-adenosylmethionine biosynthetic process(GO:0006556)
0.0	0.0	GO:0090611	ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway(GO:0090611)
0.0	0.0	GO:0071394	cellular response to testosterone stimulus(GO:0071394)
0.0	0.0	GO:0051918	negative regulation of fibrinolysis(GO:0051918)
0.0	0.1	GO:0009083	branched-chain amino acid catabolic process(GO:0009083)
0.0	0.0	GO:0009106	lipoate metabolic process(GO:0009106)
0.0	0.0	GO:0086023	adrenergic receptor signaling pathway involved in heart process(GO:0086023)
0.0	0.1	GO:0033227	dsRNA transport(GO:0033227)
0.0	0.0	GO:0070294	renal sodium ion absorption(GO:0070294)
0.0	0.2	GO:0045070	positive regulation of viral genome replication(GO:0045070)
0.0	0.1	GO:0006390	transcription from mitochondrial promoter(GO:0006390)
0.0	0.1	GO:0010640	regulation of platelet-derived growth factor receptor signaling pathway(GO:0010640)
0.0	0.2	GO:0010842	retina layer formation(GO:0010842)
0.0	0.1	GO:0046548	retinal rod cell development(GO:0046548)
0.0	0.1	GO:0008054	negative regulation of cyclin-dependent protein serine/threonine kinase by cyclin degradation(GO:0008054)
0.0	0.0	GO:0036506	maintenance of unfolded protein(GO:0036506) maintenance of unfolded protein involved in ERAD pathway(GO:1904378)
0.0	0.0	GO:1904714	regulation of chaperone-mediated autophagy(GO:1904714)
0.0	0.0	GO:0072053	renal inner medulla development(GO:0072053)
0.0	0.1	GO:0034145	positive regulation of toll-like receptor 4 signaling pathway(GO:0034145)
0.0	0.0	GO:2000481	positive regulation of cAMP-dependent protein kinase activity(GO:2000481)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.2	GO:0035985	senescence-associated heterochromatin focus(GO:0035985)
0.1	0.2	GO:0097513	myosin II filament(GO:0097513)
0.1	0.2	GO:0097443	sorting endosome(GO:0097443)
0.1	0.2	GO:0020016	ciliary pocket(GO:0020016) ciliary pocket membrane(GO:0020018)
0.0	0.1	GO:0035838	growing cell tip(GO:0035838)
0.0	0.2	GO:0030062	mitochondrial tricarboxylic acid cycle enzyme complex(GO:0030062)
0.0	0.1	GO:0032777	Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.0	0.1	GO:0008282	ATP-sensitive potassium channel complex(GO:0008282)
0.0	0.1	GO:0032541	cortical endoplasmic reticulum(GO:0032541)
0.0	0.1	GO:0072487	MSL complex(GO:0072487)
0.0	0.1	GO:0005956	protein kinase CK2 complex(GO:0005956)
0.0	0.3	GO:0044327	dendritic spine head(GO:0044327)
0.0	0.1	GO:1990604	IRE1-TRAF2-ASK1 complex(GO:1990604)
0.0	0.0	GO:1990597	AIP1-IRE1 complex(GO:1990597)
0.0	0.1	GO:0061689	tricellular tight junction(GO:0061689)
0.0	0.1	GO:0005899	insulin receptor complex(GO:0005899)
0.0	0.2	GO:0031931	TORC1 complex(GO:0031931)
0.0	0.1	GO:0002142	stereocilia ankle link complex(GO:0002142)
0.0	0.1	GO:0071664	catenin-TCF7L2 complex(GO:0071664)
0.0	0.4	GO:0002102	podosome(GO:0002102)
0.0	0.1	GO:0008091	spectrin(GO:0008091)
0.0	0.1	GO:0042406	extrinsic component of endoplasmic reticulum membrane(GO:0042406)
0.0	0.1	GO:0032021	NELF complex(GO:0032021)
0.0	0.2	GO:0060091	kinocilium(GO:0060091)
0.0	0.0	GO:0005608	laminin-3 complex(GO:0005608)
0.0	0.1	GO:1990246	uniplex complex(GO:1990246)
0.0	0.1	GO:0070552	BRISC complex(GO:0070552)
0.0	0.0	GO:0061574	ASAP complex(GO:0061574)
0.0	0.1	GO:0031464	Cul4A-RING E3 ubiquitin ligase complex(GO:0031464)
0.0	0.1	GO:0014731	spectrin-associated cytoskeleton(GO:0014731)
0.0	0.1	GO:0070761	pre-snoRNP complex(GO:0070761)
0.0	0.1	GO:0000138	Golgi trans cisterna(GO:0000138)
0.0	0.2	GO:0016442	RISC complex(GO:0016442) RNAi effector complex(GO:0031332)
0.0	0.2	GO:0048188	Set1C/COMPASS complex(GO:0048188)
0.0	0.1	GO:0005610	laminin-5 complex(GO:0005610)
0.0	0.1	GO:0044615	nuclear pore nuclear basket(GO:0044615)
0.0	0.1	GO:0031315	extrinsic component of mitochondrial outer membrane(GO:0031315)
0.0	0.1	GO:0000235	astral microtubule(GO:0000235)
0.0	0.1	GO:0044613	nuclear pore central transport channel(GO:0044613)
0.0	0.0	GO:0002193	MAML1-RBP-Jkappa- ICN1 complex(GO:0002193)
0.0	0.1	GO:0005577	fibrinogen complex(GO:0005577)
0.0	0.0	GO:0070522	ERCC4-ERCC1 complex(GO:0070522)
0.0	0.1	GO:0030008	TRAPP complex(GO:0030008)
0.0	0.0	GO:0044322	endoplasmic reticulum quality control compartment(GO:0044322)
0.0	0.1	GO:0017119	Golgi transport complex(GO:0017119)
0.0	0.3	GO:0035145	exon-exon junction complex(GO:0035145)
0.0	0.1	GO:0005750	mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275)
0.0	0.1	GO:0005671	Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)
0.0	0.1	GO:0033588	Elongator holoenzyme complex(GO:0033588)
0.0	0.0	GO:1990726	Lsm1-7-Pat1 complex(GO:1990726)
0.0	0.1	GO:0044194	cytolytic granule(GO:0044194)
0.0	0.1	GO:0036513	Derlin-1 retrotranslocation complex(GO:0036513)
0.0	0.0	GO:0070578	RISC-loading complex(GO:0070578)
0.0	0.1	GO:0016600	flotillin complex(GO:0016600)
0.0	0.0	GO:0031933	telomeric heterochromatin(GO:0031933)
0.0	0.1	GO:0000127	transcription factor TFIIIC complex(GO:0000127)
0.0	0.0	GO:0071818	BAT3 complex(GO:0071818) ER membrane insertion complex(GO:0072379)
0.0	0.1	GO:0097197	tetraspanin-enriched microdomain(GO:0097197)
0.0	0.0	GO:0031428	box C/D snoRNP complex(GO:0031428)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.2	GO:0004720	protein-lysine 6-oxidase activity(GO:0004720)
0.1	0.2	GO:0051575	5'-deoxyribose-5-phosphate lyase activity(GO:0051575)
0.0	0.3	GO:0005021	vascular endothelial growth factor-activated receptor activity(GO:0005021)
0.0	0.3	GO:0019211	phosphatase activator activity(GO:0019211)
0.0	0.1	GO:0045504	dynein heavy chain binding(GO:0045504)
0.0	0.1	GO:1901702	urate transmembrane transporter activity(GO:0015143) salt transmembrane transporter activity(GO:1901702)
0.0	0.1	GO:0031752	D5 dopamine receptor binding(GO:0031752)
0.0	0.2	GO:0003953	NAD+ nucleosidase activity(GO:0003953)
0.0	0.1	GO:0004724	magnesium-dependent protein serine/threonine phosphatase activity(GO:0004724)
0.0	0.1	GO:0071074	eukaryotic initiation factor eIF2 binding(GO:0071074)
0.0	0.1	GO:0004740	pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740)
0.0	0.2	GO:0016623	aldehyde oxidase activity(GO:0004031) oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor(GO:0016623)
0.0	0.2	GO:0070290	N-acylphosphatidylethanolamine-specific phospholipase D activity(GO:0070290)
0.0	0.1	GO:0031871	proteinase activated receptor binding(GO:0031871)
0.0	0.2	GO:0000339	RNA cap binding(GO:0000339)
0.0	0.1	GO:0050692	DBD domain binding(GO:0050692)
0.0	0.3	GO:0030898	actin-dependent ATPase activity(GO:0030898)
0.0	0.2	GO:0034889	alkyl sulfatase activity(GO:0018741) endosulfan hemisulfate sulfatase activity(GO:0034889) endosulfan sulfate hydrolase activity(GO:0034902)
0.0	0.1	GO:0005001	transmembrane receptor protein tyrosine phosphatase activity(GO:0005001)
0.0	0.0	GO:0003996	acyl-CoA ligase activity(GO:0003996)
0.0	0.1	GO:0016647	oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor(GO:0016647)
0.0	0.3	GO:0030676	Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0	0.1	GO:2001069	glycogen binding(GO:2001069)
0.0	0.2	GO:0001091	RNA polymerase II basal transcription factor binding(GO:0001091)
0.0	0.2	GO:0022889	L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889)
0.0	0.5	GO:0046966	thyroid hormone receptor binding(GO:0046966)
0.0	0.1	GO:0015165	pyrimidine nucleotide-sugar transmembrane transporter activity(GO:0015165)
0.0	0.2	GO:0008093	cytoskeletal adaptor activity(GO:0008093)
0.0	0.0	GO:0008525	phosphatidylcholine transporter activity(GO:0008525)
0.0	0.1	GO:0008131	primary amine oxidase activity(GO:0008131)
0.0	0.1	GO:1904264	ubiquitin protein ligase activity involved in ERAD pathway(GO:1904264)
0.0	0.1	GO:0070538	oleic acid binding(GO:0070538)
0.0	0.1	GO:0051733	ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity(GO:0046404) polydeoxyribonucleotide kinase activity(GO:0051733)
0.0	0.1	GO:0050833	pyruvate transmembrane transporter activity(GO:0050833)
0.0	0.1	GO:0005030	neurotrophin receptor activity(GO:0005030)
0.0	0.1	GO:0070915	lysophosphatidic acid receptor activity(GO:0070915)
0.0	0.1	GO:0016715	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen(GO:0016715)
0.0	0.1	GO:0004095	carnitine O-palmitoyltransferase activity(GO:0004095)
0.0	0.1	GO:0071558	histone demethylase activity (H3-K27 specific)(GO:0071558)
0.0	0.1	GO:0051430	corticotropin-releasing hormone receptor 1 binding(GO:0051430)
0.0	0.2	GO:0016813	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.0	0.1	GO:0004699	calcium-independent protein kinase C activity(GO:0004699)
0.0	0.1	GO:0016532	superoxide dismutase copper chaperone activity(GO:0016532)
0.0	0.1	GO:0004468	lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468)
0.0	0.1	GO:0035005	1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.0	0.1	GO:0004558	alpha-1,4-glucosidase activity(GO:0004558)
0.0	0.1	GO:0008097	5S rRNA binding(GO:0008097)
0.0	0.1	GO:0034791	3-(3-hydroxyphenyl)propionate hydroxylase activity(GO:0008688) 4-chlorobenzaldehyde oxidase activity(GO:0018471) 3,5-xylenol methylhydroxylase activity(GO:0018630) phenylacetate hydroxylase activity(GO:0018631) 4-nitrophenol 4-monooxygenase activity(GO:0018632) dimethyl sulfide monooxygenase activity(GO:0018633) alpha-pinene monooxygenase [NADH] activity(GO:0018634) 1-hydroxy-2-naphthoate hydroxylase activity(GO:0018637) toluene 4-monooxygenase activity(GO:0018638) xylene monooxygenase activity(GO:0018639) dibenzothiophene monooxygenase activity(GO:0018640) 6-hydroxy-3-methyl-2-oxo-1,2-dihydroquinoline 6-monooxygenase activity(GO:0018641) chlorophenol 4-monooxygenase activity(GO:0018642) carbon disulfide oxygenase activity(GO:0018643) toluene 2-monooxygenase activity(GO:0018644) 1-hydroxy-2-oxolimonene 1,2-monooxygenase activity(GO:0018646) phenanthrene 1,2-monooxygenase activity(GO:0018647) tetrahydrofuran hydroxylase activity(GO:0018649) styrene monooxygenase activity(GO:0018650) toluene-4-sulfonate monooxygenase activity(GO:0018651) toluene-sulfonate methyl-monooxygenase activity(GO:0018652) 3-methyl-2-oxo-1,2-dihydroquinoline 6-monooxygenase activity(GO:0018653) 2-hydroxy-phenylacetate hydroxylase activity(GO:0018654) 2-oxo-delta3-4,5,5-trimethylcyclopentenylacetyl-CoA 1,2-monooxygenase activity(GO:0018655) phenanthrene 3,4-monooxygenase activity(GO:0018656) toluene 3-monooxygenase activity(GO:0018657) 4-hydroxyphenylacetate,NADH:oxygen oxidoreductase (3-hydroxylating) activity(GO:0018660) limonene monooxygenase activity(GO:0019113) 2-methylnaphthalene hydroxylase activity(GO:0034526) 1-methylnaphthalene hydroxylase activity(GO:0034534) bisphenol A hydroxylase A activity(GO:0034560) salicylate 5-hydroxylase activity(GO:0034785) isobutylamine N-hydroxylase activity(GO:0034791) branched-chain dodecylbenzene sulfonate monooxygenase activity(GO:0034802) 3-HSA hydroxylase activity(GO:0034819) 4-hydroxypyridine-3-hydroxylase activity(GO:0034894) 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase activity(GO:0043719) 6-hydroxynicotinate 3-monooxygenase activity(GO:0043731) thalianol hydroxylase activity(GO:0080014)
0.0	0.1	GO:0046912	transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
0.0	0.0	GO:0016531	copper chaperone activity(GO:0016531)
0.0	0.0	GO:0050220	prostaglandin-E synthase activity(GO:0050220)
0.0	0.0	GO:0004813	alanine-tRNA ligase activity(GO:0004813)
0.0	0.0	GO:0072345	NAADP-sensitive calcium-release channel activity(GO:0072345)
0.0	0.1	GO:0016833	oxo-acid-lyase activity(GO:0016833)
0.0	0.1	GO:0047035	testosterone dehydrogenase (NAD+) activity(GO:0047035)
0.0	0.0	GO:0016262	protein N-acetylglucosaminyltransferase activity(GO:0016262)
0.0	0.3	GO:0005537	mannose binding(GO:0005537)
0.0	0.1	GO:0022820	potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820)
0.0	0.0	GO:0004427	inorganic diphosphatase activity(GO:0004427)
0.0	0.2	GO:0045294	alpha-catenin binding(GO:0045294)
0.0	0.2	GO:0010181	FMN binding(GO:0010181)
0.0	0.1	GO:0004774	succinate-CoA ligase activity(GO:0004774)
0.0	0.1	GO:0005173	stem cell factor receptor binding(GO:0005173)
0.0	0.1	GO:0016841	ammonia-lyase activity(GO:0016841)
0.0	0.1	GO:0070181	small ribosomal subunit rRNA binding(GO:0070181)
0.0	0.0	GO:0008142	oxysterol binding(GO:0008142)
0.0	0.1	GO:0048403	brain-derived neurotrophic factor binding(GO:0048403)
0.0	0.0	GO:0004886	9-cis retinoic acid receptor activity(GO:0004886)
0.0	0.0	GO:0051032	nucleic acid transmembrane transporter activity(GO:0051032) RNA transmembrane transporter activity(GO:0051033)
0.0	0.2	GO:0032266	phosphatidylinositol-3-phosphate binding(GO:0032266)
0.0	0.1	GO:0043262	adenosine-diphosphatase activity(GO:0043262)
0.0	0.0	GO:0004345	glucose-6-phosphate dehydrogenase activity(GO:0004345)
0.0	0.1	GO:0050321	tau-protein kinase activity(GO:0050321)
0.0	0.1	GO:0050700	CARD domain binding(GO:0050700)
0.0	0.1	GO:0016176	superoxide-generating NADPH oxidase activator activity(GO:0016176)
0.0	0.0	GO:0001069	regulatory region RNA binding(GO:0001069)
0.0	0.2	GO:0008432	JUN kinase binding(GO:0008432)
0.0	0.0	GO:0004359	glutaminase activity(GO:0004359)
0.0	0.0	GO:0003945	N-acetyllactosamine synthase activity(GO:0003945)
0.0	0.1	GO:0008193	tRNA guanylyltransferase activity(GO:0008193)
0.0	0.0	GO:0034235	GPI anchor binding(GO:0034235)
0.0	0.0	GO:0004793	threonine aldolase activity(GO:0004793) L-allo-threonine aldolase activity(GO:0008732)
0.0	0.0	GO:0015065	uridine nucleotide receptor activity(GO:0015065) G-protein coupled pyrimidinergic nucleotide receptor activity(GO:0071553)
0.0	0.0	GO:0032767	copper-dependent protein binding(GO:0032767)
0.0	0.1	GO:1990381	ubiquitin-specific protease binding(GO:1990381)
0.0	0.0	GO:0046978	TAP1 binding(GO:0046978) TAP2 binding(GO:0046979)
0.0	0.0	GO:0005094	Rho GDP-dissociation inhibitor activity(GO:0005094)
0.0	0.1	GO:0008603	cAMP-dependent protein kinase regulator activity(GO:0008603)
0.0	0.0	GO:0052650	NADP-retinol dehydrogenase activity(GO:0052650)
0.0	0.3	GO:0005212	structural constituent of eye lens(GO:0005212)
0.0	0.1	GO:0031995	insulin-like growth factor II binding(GO:0031995)
0.0	0.2	GO:0080025	phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.0	0.1	GO:0003836	beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.0	0.0	GO:0004060	arylamine N-acetyltransferase activity(GO:0004060)
0.0	0.1	GO:0017099	very-long-chain-acyl-CoA dehydrogenase activity(GO:0017099)
0.0	0.0	GO:0004735	pyrroline-5-carboxylate reductase activity(GO:0004735)

Gene overrepresentation in curated gene sets: canonical pathways category:

Total log-likelihood	Term	Description
0.1	PID HDAC CLASSII PATHWAY	Signaling events mediated by HDAC Class II
0.2	PID S1P S1P4 PATHWAY	S1P4 pathway
0.3	PID ARF6 DOWNSTREAM PATHWAY	Arf6 downstream pathway
0.0	ST WNT CA2 CYCLIC GMP PATHWAY	Wnt/Ca2+/cyclic GMP signaling.
0.1	PID LYSOPHOSPHOLIPID PATHWAY	LPA receptor mediated events
0.3	PID NECTIN PATHWAY	Nectin adhesion pathway
0.3	PID ALPHA SYNUCLEIN PATHWAY	Alpha-synuclein signaling
0.1	SA TRKA RECEPTOR	The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.
0.3	PID INTEGRIN2 PATHWAY	Beta2 integrin cell surface interactions
0.2	PID IL2 STAT5 PATHWAY	IL2 signaling events mediated by STAT5

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION	Genes involved in APOBEC3G mediated resistance to HIV-1 infection
0.0	0.1	REACTOME VEGF LIGAND RECEPTOR INTERACTIONS	Genes involved in VEGF ligand-receptor interactions
0.0	0.3	REACTOME SIGNALING BY NOTCH4	Genes involved in Signaling by NOTCH4
0.0	0.2	REACTOME THE ACTIVATION OF ARYLSULFATASES	Genes involved in The activation of arylsulfatases
0.0	0.2	REACTOME PROLACTIN RECEPTOR SIGNALING	Genes involved in Prolactin receptor signaling
0.0	0.0	REACTOME PI3K AKT ACTIVATION	Genes involved in PI3K/AKT activation
0.0	0.2	REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS	Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
0.0	0.0	REACTOME PEPTIDE CHAIN ELONGATION	Genes involved in Peptide chain elongation
0.0	0.1	REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK	Genes involved in Negative regulation of the PI3K/AKT network
0.0	0.1	REACTOME AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL	Genes involved in AKT phosphorylates targets in the cytosol
0.0	0.1	REACTOME ABACAVIR TRANSPORT AND METABOLISM	Genes involved in Abacavir transport and metabolism
0.0	0.3	REACTOME SULFUR AMINO ACID METABOLISM	Genes involved in Sulfur amino acid metabolism
0.0	0.2	REACTOME SIGNALING BY BMP	Genes involved in Signaling by BMP
0.0	0.3	REACTOME SYNTHESIS OF PA	Genes involved in Synthesis of PA
0.0	0.2	REACTOME PYRUVATE METABOLISM	Genes involved in Pyruvate metabolism
0.0	0.1	REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS	Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0	0.1	REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS	Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.0	0.1	REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS	Genes involved in Apoptotic cleavage of cell adhesion proteins