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ENCSR904DTN: DNase-seq of mouse liver in constant darkness

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for Relb

Z-value: 0.89

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Transcription factors associated with Relb

Gene Symbol	Gene ID	Gene Info
Relb Ensembl NCBI MGI UniProt	ENSMUSG00000002983.10	Relb

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

Gene	Promoter	Distance	Association probability	Pearson corr. coef.	P-value	Plot
Relb	chr7_19631131_19631299	1777	0.175563	-0.73	9.8e-02	Click!
Relb	chr7_19619136_19619293	9220	0.084860	-0.70	1.2e-01	Click!
Relb	chr7_19628765_19628929	63	0.938451	0.46	3.6e-01	Click!
Relb	chr7_19628515_19628680	124	0.914468	0.44	3.8e-01	Click!
Relb	chr7_19629111_19629282	52	0.941131	0.15	7.8e-01	Click!

Activity of the Relb motif across conditions

Conditions sorted by the z-value of the Relb motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr7_141628129_141628296	1.33	Mir7063	microRNA 7063	7511	0.13
chr17_31828262_31828413	1.24	Sik1	salt inducible kinase 1	23238	0.14
chr6_125527760_125527927	1.01	Vwf	Von Willebrand factor	18931	0.15
chr8_11373743_11373894	0.52	Col4a2	collagen, type IV, alpha 2	31090	0.13
chr10_38970068_38970231	0.48	Lama4	laminin, alpha 4	4477	0.27
chr13_93989307_93989458	0.48	Gm47216	predicted gene, 47216	2386	0.28
chr7_46723990_46724178	0.41	Saa3	serum amyloid A 3	8384	0.09
chr6_99375099_99375287	0.40	Gm20705	predicted gene 20705	13306	0.23
chr4_43492855_43493028	0.38	Ccdc107	coiled-coil domain containing 107	41	0.58
chr12_104247702_104247874	0.38	Serpina3h	serine (or cysteine) peptidase inhibitor, clade A, member 3H	117	0.93
chr2_169790587_169791240	0.37	Tshz2	teashirt zinc finger family member 2	93980	0.08
chr12_8386824_8386996	0.37	Gm48075	predicted gene, 48075	7299	0.18
chr2_129340331_129340510	0.37	Gm14039	predicted gene 14039	22439	0.09
chr8_127196588_127196779	0.37	Pard3	par-3 family cell polarity regulator	25279	0.24
chr12_79600452_79600623	0.36	Rad51b	RAD51 paralog B	273184	0.01
chr6_115996180_115996399	0.34	Plxnd1	plexin D1	1284	0.4
chr17_45557476_45557627	0.33	Nfkbie	nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, epsilon	1812	0.18
chr18_75405710_75405888	0.33	Smad7	SMAD family member 7	30885	0.18
chr1_182758644_182758936	0.31	Susd4	sushi domain containing 4	5070	0.21
chr9_5308705_5308876	0.30	Casp4	caspase 4, apoptosis-related cysteine peptidase	38	0.98
chr6_94996352_94996560	0.29	4930511E03Rik	RIKEN cDNA 4930511E03 gene	52622	0.13
chr1_57989000_57989391	0.29	Sgo2a	shugoshin 2A	6776	0.19
chr6_3384983_3385179	0.29	Samd9l	sterile alpha motif domain containing 9-like	75	0.97
chr17_87365352_87365503	0.29	0610012D04Rik	RIKEN cDNA 0610012D04 gene	965	0.48
chr15_66814050_66814231	0.29	Sla	src-like adaptor	1547	0.4
chr2_35658400_35658598	0.29	Dab2ip	disabled 2 interacting protein	2851	0.31
chr6_121303535_121303719	0.28	Slc6a13	solute carrier family 6 (neurotransmitter transporter, GABA), member 13	2845	0.19
chr2_25534308_25534469	0.28	Traf2	TNF receptor-associated factor 2	4752	0.08
chr3_105803714_105803865	0.28	Rap1a	RAS-related protein 1a	2453	0.17
chr8_11394936_11395099	0.27	Col4a2	collagen, type IV, alpha 2	9891	0.16
chr10_127962398_127962784	0.27	Gm47949	predicted gene, 47949	1035	0.33
chr3_97232474_97232625	0.26	Bcl9	B cell CLL/lymphoma 9	3703	0.21
chr8_48944740_48944906	0.26	Gm25830	predicted gene, 25830	13658	0.25
chr16_50753691_50753842	0.26	Dubr	Dppa2 upstream binding RNA	20993	0.17
chr11_114867640_114867800	0.25	Gprc5c	G protein-coupled receptor, family C, group 5, member C	3228	0.17
chr11_16906555_16906817	0.25	Egfr	epidermal growth factor receptor	1501	0.41
chr9_113749434_113749589	0.24	Clasp2	CLIP associating protein 2	7779	0.2
chr11_98459290_98459441	0.24	Grb7	growth factor receptor bound protein 7	5576	0.1
chr2_93214308_93214479	0.24	Tspan18	tetraspanin 18	13393	0.2
chr2_85172170_85172321	0.24	Gm13713	predicted gene 13713	11467	0.11
chr5_75377802_75378010	0.24	Gm22084	predicted gene, 22084	5761	0.2
chr18_60803553_60803864	0.23	Cd74	CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated)	140	0.94
chr1_155063987_155064316	0.23	Gm29282	predicted gene 29282	6972	0.17
chr14_20970523_20970838	0.23	Vcl	vinculin	41282	0.14
chr5_143055727_143055894	0.22	Gm43378	predicted gene 43378	5767	0.15
chr1_4622515_4622679	0.22	Gm7369	predicted gene 7369	12126	0.15
chr7_141429982_141430161	0.22	Cend1	cell cycle exit and neuronal differentiation 1	580	0.43
chr5_91961314_91961670	0.22	Thap6	THAP domain containing 6	897	0.35
chr12_55492611_55492778	0.22	Nfkbia	nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha	47	0.97
chr1_40221808_40222119	0.22	Il1r1	interleukin 1 receptor, type I	3117	0.26
chr17_24204987_24205163	0.22	Tbc1d24	TBC1 domain family, member 24	407	0.66
chr3_95635932_95636096	0.21	E330034L11Rik	RIKEN cDNA E330034L11 gene	3290	0.12
chr8_11221370_11221555	0.21	Col4a1	collagen, type IV, alpha 1	4193	0.21
chr7_25120549_25120733	0.21	Pou2f2	POU domain, class 2, transcription factor 2	217	0.89
chr3_149326826_149327020	0.21	Gm30382	predicted gene, 30382	3049	0.25
chr17_83277496_83277647	0.21	Gm24240	predicted gene, 24240	7600	0.2
chr13_64179357_64179534	0.21	Habp4	hyaluronic acid binding protein 4	5058	0.13
chr5_123607373_123607580	0.21	Clip1	CAP-GLY domain containing linker protein 1	3666	0.14
chr7_16830530_16830865	0.21	Strn4	striatin, calmodulin binding protein 4	402	0.73
chr19_41347409_41347564	0.20	Pik3ap1	phosphoinositide-3-kinase adaptor protein 1	37610	0.17
chr7_68709256_68709407	0.20	Gm44692	predicted gene 44692	17136	0.21
chr14_79512054_79512205	0.20	Elf1	E74-like factor 1	3545	0.2
chr10_4135364_4135517	0.20	Gm25515	predicted gene, 25515	31127	0.16
chr8_124634513_124634671	0.20	Capn9	calpain 9	21152	0.14
chr10_112953941_112954181	0.20	Gm47519	predicted gene, 47519	6127	0.18
chr3_10310720_10310871	0.20	Gm38364	predicted gene, 38364	1747	0.2
chr15_31367525_31367697	0.20	Ankrd33b	ankyrin repeat domain 33B	43	0.93
chr5_86885878_86886051	0.20	Ugt2b34	UDP glucuronosyltransferase 2 family, polypeptide B34	20973	0.1
chr19_44900544_44900723	0.20	Slf2	SMC5-SMC6 complex localization factor 2	30518	0.11
chr12_104262958_104263126	0.20	Serpina3i	serine (or cysteine) peptidase inhibitor, clade A, member 3I	80	0.94
chr12_86612676_86612827	0.20	Gm8504	predicted gene 8504	37822	0.13
chr2_70559621_70559796	0.20	Gad1	glutamate decarboxylase 1	2334	0.22
chr4_123412152_123412346	0.20	Macf1	microtubule-actin crosslinking factor 1	21	0.97
chr2_50964157_50964313	0.20	Gm13498	predicted gene 13498	54551	0.16
chr15_85611891_85612067	0.19	Wnt7b	wingless-type MMTV integration site family, member 7B	29506	0.12
chr1_133493490_133493663	0.19	Gm8596	predicted gene 8596	35903	0.14
chr10_4107762_4107973	0.19	Gm25515	predicted gene, 25515	3554	0.27
chr10_19087108_19087313	0.19	1700124M09Rik	RIKEN cDNA 1700124M09 gene	32	0.97
chr10_80050367_80050530	0.19	Gpx4	glutathione peroxidase 4	3040	0.12
chr19_46484022_46484320	0.19	Sufu	SUFU negative regulator of hedgehog signaling	1074	0.46
chr8_120738772_120739041	0.19	Irf8	interferon regulatory factor 8	267	0.89
chr12_13177714_13177865	0.19	Gm24208	predicted gene, 24208	14026	0.16
chr11_72953535_72953727	0.18	Gm44467	predicted gene, 44467	524	0.7
chr11_59804844_59804999	0.18	Flcn	folliculin	4667	0.11
chr19_37239252_37239415	0.18	Gm25268	predicted gene, 25268	5849	0.15
chr8_46739715_46739866	0.18	Irf2	interferon regulatory factor 2	6	0.8
chr2_60283319_60283522	0.18	Cd302	CD302 antigen	998	0.5
chr4_40873404_40873555	0.18	B4galt1	UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1	19474	0.1
chr17_31827276_31827455	0.18	Sik1	salt inducible kinase 1	24210	0.14
chr7_19867840_19868009	0.18	Gm44659	predicted gene 44659	3514	0.09
chr4_47251261_47251412	0.18	Col15a1	collagen, type XV, alpha 1	7199	0.22
chr11_77792590_77792910	0.18	Gm10277	predicted gene 10277	5003	0.16
chr15_22791886_22792091	0.18	Hnrnpa1l2-ps2	heterogeneous nuclear ribonucleoprotein A1-like 2, pseudogene 2	77158	0.12
chr19_10599348_10599499	0.18	Tkfc	triokinase, FMN cyclase	4835	0.1
chr10_62231949_62232100	0.17	Tspan15	tetraspanin 15	773	0.6
chr9_72660282_72660433	0.17	Nedd4	neural precursor cell expressed, developmentally down-regulated 4	1989	0.18
chr2_152343770_152343958	0.17	Trib3	tribbles pseudokinase 3	106	0.92
chr4_104814139_104814345	0.17	C8b	complement component 8, beta polypeptide	15034	0.21
chr2_129380876_129381038	0.17	Spcs2-ps	signal peptidase complex subunit 2, pseudogene	1561	0.27
chr4_150787040_150787400	0.17	Gm13049	predicted gene 13049	38513	0.13
chr2_122158376_122158599	0.17	Trim69	tripartite motif-containing 69	2213	0.19
chr6_31075878_31076320	0.17	Lncpint	long non-protein coding RNA, Trp53 induced transcript	11505	0.11
chr7_80130219_80130425	0.17	Idh2	isocitrate dehydrogenase 2 (NADP+), mitochondrial	14930	0.1
chr5_149045840_149046001	0.17	Hmgb1	high mobility group box 1	4527	0.13
chr4_128989568_128989760	0.17	Ak2	adenylate kinase 2	2294	0.25
chr3_97972968_97973119	0.17	Notch2	notch 2	40484	0.11
chr14_29987413_29987605	0.16	Mir6947	microRNA 6947	1379	0.24
chr11_16773276_16773438	0.16	Egfr	epidermal growth factor receptor	21127	0.18
chr19_32298377_32298611	0.16	Sgms1	sphingomyelin synthase 1	8915	0.24
chr4_53187279_53187439	0.16	Abca1	ATP-binding cassette, sub-family A (ABC1), member 1	27464	0.15
chr6_113668529_113668873	0.16	Irak2	interleukin-1 receptor-associated kinase 2	149	0.89
chr7_110689414_110689588	0.16	Gm21123	predicted gene, 21123	10233	0.15
chr3_135307876_135308027	0.16	Slc9b2	solute carrier family 9, subfamily B (NHA2, cation proton antiporter 2), member 2	206	0.92
chr11_100719386_100719554	0.16	Hspb9	heat shock protein, alpha-crystallin-related, B9	5548	0.1
chr17_3989752_3989920	0.16	4930470H14Rik	RIKEN cDNA 4930470H14 gene	93159	0.09
chrX_20862192_20862360	0.16	Mir5617	microRNA 5617	906	0.41
chr2_147782596_147782759	0.16	A530006G24Rik	RIKEN cDNA A530006G24 gene	71984	0.1
chr14_100284919_100285099	0.15	Klf12	Kruppel-like factor 12	330	0.83
chr6_136938692_136939081	0.15	Arhgdib	Rho, GDP dissociation inhibitor (GDI) beta	705	0.59
chr9_98675729_98675890	0.15	Pisrt1	polled intersex syndrome regulated transcript 1	30457	0.13
chr10_94093554_94093705	0.15	Gm18391	predicted gene, 18391	4511	0.15
chr10_91080633_91080784	0.15	Apaf1	apoptotic peptidase activating factor 1	1721	0.28
chr7_16312800_16312989	0.15	Bbc3	BCL2 binding component 3	623	0.6
chr1_136859525_136859810	0.15	Gm17781	predicted gene, 17781	60708	0.09
chr7_3290355_3290515	0.15	Myadm	myeloid-associated differentiation marker	99	0.9
chr12_69365915_69366084	0.15	Gm18113	predicted gene, 18113	4024	0.11
chr11_34086328_34086662	0.15	Lcp2	lymphocyte cytosolic protein 2	509	0.8
chr10_127147265_127147440	0.15	Gm23664	predicted gene, 23664	8735	0.08
chr17_79068246_79068411	0.15	Qpct	glutaminyl-peptide cyclotransferase (glutaminyl cyclase)	8674	0.17
chr6_113238509_113238719	0.15	Mtmr14	myotubularin related protein 14	717	0.56
chr16_29882571_29882722	0.15	Gm32679	predicted gene, 32679	47918	0.12
chr12_91696351_91696512	0.15	Gm8378	predicted gene 8378	10318	0.16
chr14_63899614_63899769	0.14	Pinx1	PIN2/TERF1 interacting, telomerase inhibitor 1	78	0.98
chr18_61360632_61360830	0.14	Gm25301	predicted gene, 25301	37082	0.11
chr7_79311533_79311809	0.14	Gm39041	predicted gene, 39041	12646	0.14
chr16_31066805_31066992	0.14	Xxylt1	xyloside xylosyltransferase 1	955	0.57
chr14_101652712_101652891	0.14	Uchl3	ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase)	1166	0.44
chr2_158302944_158303106	0.14	Lbp	lipopolysaccharide binding protein	3468	0.15
chr11_5734457_5734620	0.14	Urgcp	upregulator of cell proliferation	6608	0.13
chr12_86904302_86904504	0.14	Irf2bpl	interferon regulatory factor 2 binding protein-like	19605	0.16
chr11_54956028_54956193	0.14	Tnip1	TNFAIP3 interacting protein 1	6	0.97
chr10_3718557_3718760	0.14	Plekhg1	pleckstrin homology domain containing, family G (with RhoGef domain) member 1	21706	0.25
chr8_128488839_128489004	0.14	Nrp1	neuropilin 1	129524	0.05
chr7_98535989_98536157	0.14	A630091E08Rik	RIKEN cDNA A630091E08 gene	26917	0.12
chr18_61331637_61332092	0.13	Pde6a	phosphodiesterase 6A, cGMP-specific, rod, alpha	56841	0.08
chr2_10128611_10128912	0.13	Itih2	inter-alpha trypsin inhibitor, heavy chain 2	1902	0.23
chr5_90891009_90891200	0.13	Cxcl1	chemokine (C-X-C motif) ligand 1	137	0.93
chr11_61608212_61608363	0.13	Epn2	epsin 2	28600	0.13
chr19_47330818_47330996	0.13	Sh3pxd2a	SH3 and PX domains 2A	16156	0.18
chr12_84193897_84194204	0.13	Elmsan1	ELM2 and Myb/SANT-like domain containing 1	35	0.95
chr5_88796583_88796899	0.13	Gm42912	predicted gene 42912	2845	0.21
chr1_23268164_23268335	0.13	Mir30a	microRNA 30a	4020	0.14
chr5_110980028_110980206	0.13	Gm42778	predicted gene 42778	1452	0.34
chr17_34627479_34627653	0.13	Ppt2	palmitoyl-protein thioesterase 2	41	0.69
chr9_66276951_66277383	0.13	Dapk2	death-associated protein kinase 2	8793	0.23
chr12_26356269_26356452	0.13	4930549C15Rik	RIKEN cDNA 4930549C15 gene	9643	0.19
chr14_27101523_27101762	0.13	Arhgef3	Rho guanine nucleotide exchange factor (GEF) 3	13257	0.19
chr10_59441733_59442104	0.13	Oit3	oncoprotein induced transcript 3	140	0.96
chr10_77434735_77434942	0.13	Adarb1	adenosine deaminase, RNA-specific, B1	16568	0.16
chr11_101965679_101965853	0.13	Sost	sclerostin	1249	0.27
chr17_74630898_74631071	0.13	Birc6	baculoviral IAP repeat-containing 6	4738	0.22
chr14_76698781_76698988	0.12	1700108F19Rik	RIKEN cDNA 1700108F19 gene	17130	0.2
chr1_133863573_133863878	0.12	Gm28441	predicted gene 28441	28536	0.11
chr15_36361442_36361595	0.12	Gm33936	predicted gene, 33936	5589	0.14
chr4_138065715_138066098	0.12	Eif4g3	eukaryotic translation initiation factor 4 gamma, 3	61154	0.1
chr17_74331435_74331594	0.12	Gm9351	predicted gene 9351	1015	0.34
chr9_70328368_70328519	0.12	Mir5626	microRNA 5626	77310	0.08
chr15_82294106_82294257	0.12	Wbp2nl	WBP2 N-terminal like	4773	0.09
chr14_118591597_118591757	0.12	Mir6391	microRNA 6391	795	0.61
chr1_170589945_170590114	0.12	Nos1ap	nitric oxide synthase 1 (neuronal) adaptor protein	168	0.96
chr2_118513077_118513244	0.12	Gm13983	predicted gene 13983	28983	0.12
chr5_129021137_129021430	0.12	Ran	RAN, member RAS oncogene family	1011	0.56
chr8_125557731_125557884	0.12	Sipa1l2	signal-induced proliferation-associated 1 like 2	11896	0.23
chr16_23204539_23205077	0.12	Gm15746	predicted gene 15746	6687	0.1
chr15_102671840_102672003	0.12	Mir688	microRNA 688	55	0.85
chr17_29395434_29395615	0.12	Fgd2	FYVE, RhoGEF and PH domain containing 2	19023	0.11
chr1_195012643_195012824	0.12	9630010A21Rik	RIKEN cDNA 9630010A21 gene	1013	0.32
chr6_97457292_97457492	0.12	Frmd4b	FERM domain containing 4B	1894	0.36
chr5_123257174_123257325	0.12	Rpl35a-ps6	ribosomal protein L35A, pseudogene 6	1436	0.26
chr16_23060324_23060755	0.12	Kng1	kininogen 1	2146	0.13
chr11_4974491_4974717	0.12	Ap1b1	adaptor protein complex AP-1, beta 1 subunit	12220	0.13
chr4_139611543_139611704	0.12	Gm21969	predicted gene 21969	8437	0.14
chr2_70870934_70871085	0.12	Gm13632	predicted gene 13632	6820	0.2
chr11_97406666_97406821	0.11	Arhgap23	Rho GTPase activating protein 23	8790	0.15
chr5_113207341_113207492	0.11	2900026A02Rik	RIKEN cDNA 2900026A02 gene	13820	0.13
chr9_53390887_53391256	0.11	Poglut3	protein O-glucosyltransferase 3	454	0.78
chr10_93919382_93919541	0.11	Gm48126	predicted gene, 48126	371	0.79
chr16_4399765_4400133	0.11	Adcy9	adenylate cyclase 9	19638	0.19
chr5_137493763_137493914	0.11	Epo	erythropoietin	8022	0.07
chr13_107676889_107677059	0.11	1700006H21Rik	RIKEN cDNA 1700006H21 gene	10423	0.23
chr4_133703497_133703648	0.11	Mir7227	microRNA 7227	13536	0.12
chr19_55916323_55916507	0.11	Tcf7l2	transcription factor 7 like 2, T cell specific, HMG box	18106	0.24
chr2_122147524_122147696	0.11	B2m	beta-2 microglobulin	76	0.95
chr19_55063941_55064146	0.11	Gpam	glycerol-3-phosphate acyltransferase, mitochondrial	35408	0.17
chr19_29138834_29139228	0.11	Mir101b	microRNA 101b	3752	0.18
chr13_31180346_31180513	0.11	Gm11372	predicted gene 11372	18657	0.21
chr5_135118666_135118877	0.11	Gm43500	predicted gene 43500	4522	0.11
chr19_26951406_26951563	0.11	Gm815	predicted gene 815	65559	0.11
chr1_36064998_36065160	0.11	Hs6st1	heparan sulfate 6-O-sulfotransferase 1	3321	0.19
chr9_66510150_66510491	0.11	Fbxl22	F-box and leucine-rich repeat protein 22	4289	0.19

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of Relb

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View png image

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Total log-likelihood	Term	Description
0.1	GO:1904742	regulation of telomeric DNA binding(GO:1904742)
0.1	GO:0090038	negative regulation of protein kinase C signaling(GO:0090038)
0.2	GO:0002901	mature B cell apoptotic process(GO:0002901) regulation of mature B cell apoptotic process(GO:0002905) negative regulation of mature B cell apoptotic process(GO:0002906)
0.4	GO:0035234	ectopic germ cell programmed cell death(GO:0035234)
0.1	GO:0070947	neutrophil mediated killing of fungus(GO:0070947)
0.1	GO:1903800	positive regulation of production of miRNAs involved in gene silencing by miRNA(GO:1903800)
0.1	GO:2001206	positive regulation of osteoclast development(GO:2001206)
0.1	GO:0021699	cerebellar cortex maturation(GO:0021699)
0.2	GO:0032792	negative regulation of CREB transcription factor activity(GO:0032792)
0.3	GO:0034058	endosomal vesicle fusion(GO:0034058)
0.1	GO:1901896	positive regulation of calcium-transporting ATPase activity(GO:1901896)
0.1	GO:0043553	negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553)
0.1	GO:0097460	ferrous iron import into cell(GO:0097460)
0.2	GO:0007253	cytoplasmic sequestering of NF-kappaB(GO:0007253)
0.1	GO:0060666	dichotomous subdivision of terminal units involved in salivary gland branching(GO:0060666)
0.1	GO:0021776	smoothened signaling pathway involved in ventral spinal cord interneuron specification(GO:0021775) smoothened signaling pathway involved in spinal cord motor neuron cell fate specification(GO:0021776)
0.1	GO:1900740	regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900739) positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900740)
0.2	GO:0038063	collagen-activated tyrosine kinase receptor signaling pathway(GO:0038063)
0.2	GO:0006620	posttranslational protein targeting to membrane(GO:0006620)
0.1	GO:0007181	transforming growth factor beta receptor complex assembly(GO:0007181)
0.1	GO:2000169	regulation of peptidyl-cysteine S-nitrosylation(GO:2000169)
0.1	GO:1901164	negative regulation of trophoblast cell migration(GO:1901164)
0.1	GO:1903935	response to sodium arsenite(GO:1903935)
0.1	GO:0030913	paranodal junction assembly(GO:0030913)
0.1	GO:0070125	mitochondrial translational elongation(GO:0070125)
0.1	GO:0007296	vitellogenesis(GO:0007296)
0.1	GO:0046654	tetrahydrofolate biosynthetic process(GO:0046654)
0.1	GO:1902570	protein localization to nucleolus(GO:1902570)
0.0	GO:1903690	negative regulation of wound healing, spreading of epidermal cells(GO:1903690)
0.1	GO:0003383	apical constriction(GO:0003383)
0.1	GO:2000659	regulation of interleukin-1-mediated signaling pathway(GO:2000659)
0.1	GO:0002924	negative regulation of humoral immune response mediated by circulating immunoglobulin(GO:0002924)
0.0	GO:0006172	ADP biosynthetic process(GO:0006172)
0.0	GO:0009449	gamma-aminobutyric acid biosynthetic process(GO:0009449)
0.1	GO:0017196	N-terminal peptidyl-methionine acetylation(GO:0017196)
0.0	GO:1901078	negative regulation of relaxation of muscle(GO:1901078)
0.0	GO:0032741	positive regulation of interleukin-18 production(GO:0032741)
0.0	GO:1900169	regulation of glucocorticoid mediated signaling pathway(GO:1900169)
0.0	GO:0016095	polyprenol catabolic process(GO:0016095)
0.0	GO:0061470	T follicular helper cell differentiation(GO:0061470)
0.2	GO:0044130	negative regulation of growth of symbiont in host(GO:0044130) negative regulation of growth of symbiont involved in interaction with host(GO:0044146)
0.1	GO:0008063	Toll signaling pathway(GO:0008063)
0.0	GO:0035622	intrahepatic bile duct development(GO:0035622)
0.1	GO:0070498	interleukin-1-mediated signaling pathway(GO:0070498)
0.2	GO:0030277	maintenance of gastrointestinal epithelium(GO:0030277)
0.0	GO:0008635	activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c(GO:0008635)
0.1	GO:1902036	regulation of hematopoietic stem cell differentiation(GO:1902036)
0.1	GO:0042940	D-amino acid transport(GO:0042940)
0.1	GO:0006572	tyrosine catabolic process(GO:0006572)
0.0	GO:0002730	regulation of dendritic cell cytokine production(GO:0002730)
0.0	GO:0090611	ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway(GO:0090611)
0.1	GO:0010534	regulation of activation of JAK2 kinase activity(GO:0010534)
0.0	GO:2000054	negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification(GO:2000054)
0.1	GO:0045717	negative regulation of fatty acid biosynthetic process(GO:0045717)
0.0	GO:0044860	protein localization to plasma membrane raft(GO:0044860)
0.2	GO:0048305	immunoglobulin secretion(GO:0048305)
0.0	GO:0042997	negative regulation of Golgi to plasma membrane protein transport(GO:0042997)
0.0	GO:0070634	transepithelial ammonium transport(GO:0070634)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:0097169	AIM2 inflammasome complex(GO:0097169)
0.0	0.1	GO:0097487	multivesicular body, internal vesicle(GO:0097487)
0.0	0.1	GO:1990597	AIP1-IRE1 complex(GO:1990597)
0.0	0.2	GO:0098642	collagen type IV trimer(GO:0005587) network-forming collagen trimer(GO:0098642) collagen network(GO:0098645) basement membrane collagen trimer(GO:0098651)
0.0	0.1	GO:0033093	Weibel-Palade body(GO:0033093)
0.0	0.1	GO:1990712	HFE-transferrin receptor complex(GO:1990712)
0.0	0.1	GO:0031074	nucleocytoplasmic shuttling complex(GO:0031074)
0.0	0.1	GO:1990454	L-type voltage-gated calcium channel complex(GO:1990454)
0.0	0.2	GO:0042613	MHC class II protein complex(GO:0042613)
0.0	0.1	GO:0033269	internode region of axon(GO:0033269)
0.0	0.1	GO:0034673	inhibin-betaglycan-ActRII complex(GO:0034673)
0.0	0.1	GO:0031415	NatA complex(GO:0031415)
0.0	0.1	GO:0002116	semaphorin receptor complex(GO:0002116)
0.0	0.0	GO:0030981	cortical microtubule cytoskeleton(GO:0030981)
0.0	0.1	GO:0097197	tetraspanin-enriched microdomain(GO:0097197)
0.0	0.0	GO:0043293	apoptosome(GO:0043293)
0.0	0.1	GO:0005579	membrane attack complex(GO:0005579)
0.0	0.0	GO:0035355	Toll-like receptor 2-Toll-like receptor 6 protein complex(GO:0035355)
0.0	0.1	GO:0000138	Golgi trans cisterna(GO:0000138)
0.0	0.1	GO:0042406	extrinsic component of endoplasmic reticulum membrane(GO:0042406)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.2	GO:0042289	MHC class II protein binding(GO:0042289)
0.0	0.1	GO:0048408	epidermal growth factor binding(GO:0048408)
0.0	0.1	GO:0005094	Rho GDP-dissociation inhibitor activity(GO:0005094)
0.0	0.1	GO:0035662	Toll-like receptor 4 binding(GO:0035662)
0.0	0.2	GO:0008140	cAMP response element binding protein binding(GO:0008140)
0.0	0.1	GO:0061676	importin-alpha family protein binding(GO:0061676)
0.0	0.1	GO:0034920	2,3-dihydroxy DDT 1,2-dioxygenase activity(GO:0018542) phenanthrene dioxygenase activity(GO:0018555) 2,2',3-trihydroxybiphenyl dioxygenase activity(GO:0018556) 1,2-dihydroxyfluorene 1,1-alpha-dioxygenase activity(GO:0018557) 5,6-dihydroxy-3-methyl-2-oxo-1,2-dihydroquinoline dioxygenase activity(GO:0018558) 1,1-dichloro-2-(dihydroxy-4-chlorophenyl)-(4-chlorophenyl)ethene 1,2-dioxygenase activity(GO:0018559) protocatechuate 3,4-dioxygenase type II activity(GO:0018560) 2'-aminobiphenyl-2,3-diol 1,2-dioxygenase activity(GO:0018561) 3,4-dihydroxyfluorene 4,4-alpha-dioxygenase activity(GO:0018562) 2,3-dihydroxy-ethylbenzene 1,2-dioxygenase activity(GO:0018563) carbazole 1,9a-dioxygenase activity(GO:0018564) dihydroxydibenzothiophene dioxygenase activity(GO:0018565) 1,2-dihydroxynaphthalene-6-sulfonate 1,8a-dioxygenase activity(GO:0018566) styrene dioxygenase activity(GO:0018567) 3,4-dihydroxyphenanthrene dioxygenase activity(GO:0018568) hydroquinone 1,2-dioxygenase activity(GO:0018569) p-cumate 2,3-dioxygenase activity(GO:0018570) 2,3-dihydroxy-p-cumate dioxygenase activity(GO:0018571) 3,5-dichlorocatechol 1,2-dioxygenase activity(GO:0018572) 2-aminophenol 1,6-dioxygenase activity(GO:0018573) 2,6-dichloro-p-hydroquinone 1,2-dioxygenase activity(GO:0018574) chlorocatechol 1,2-dioxygenase activity(GO:0018575) catechol dioxygenase activity(GO:0019114) dihydroxyfluorene dioxygenase activity(GO:0019117) 5-aminosalicylate dioxygenase activity(GO:0034543) 3-hydroxy-2-naphthoate 2,3-dioxygenase activity(GO:0034803) benzo(a)pyrene 11,12-dioxygenase activity(GO:0034806) benzo(a)pyrene 4,5-dioxygenase activity(GO:0034808) 4,5-dihydroxybenzo(a)pyrene dioxygenase activity(GO:0034810) benzo(a)pyrene 9,10-dioxygenase activity(GO:0034811) 9,10-dihydroxybenzo(a)pyrene dioxygenase activity(GO:0034812) benzo(a)pyrene 7,8-dioxygenase activity(GO:0034813) 7,8-dihydroxy benzo(a)pyrene dioxygenase activity(GO:0034814) 1,2-dihydroxy-5,6,7,8-tetrahydronaphthalene extradiol dioxygenase activity(GO:0034827) 2-mercaptobenzothiazole dioxygenase activity(GO:0034834) pyridine-3,4-diol dioxygenase activity(GO:0034895) pyrene dioxygenase activity(GO:0034920) 4,5-dihydroxypyrene dioxygenase activity(GO:0034922) phenanthrene-4-carboxylate dioxygenase activity(GO:0034934) tetrachlorobenzene dioxygenase activity(GO:0034935) 4,6-dichloro-3-methylcatechol 1,2-dioxygenase activity(GO:0034936) 2,3-dihydroxydiphenyl ether dioxygenase activity(GO:0034955) diphenyl ether 1,2-dioxygenase activity(GO:0034956) arachidonate 8(S)-lipoxygenase activity(GO:0036403) 4-hydroxycatechol 1,2-dioxygenase activity(GO:0047074)
0.0	0.1	GO:0017034	Rap guanyl-nucleotide exchange factor activity(GO:0017034)
0.0	0.1	GO:0005332	gamma-aminobutyric acid:sodium symporter activity(GO:0005332)
0.0	0.0	GO:0004351	glutamate decarboxylase activity(GO:0004351)
0.0	0.2	GO:0070016	armadillo repeat domain binding(GO:0070016)
0.0	0.1	GO:0010521	telomerase inhibitor activity(GO:0010521)
0.0	0.0	GO:0003865	3-oxo-5-alpha-steroid 4-dehydrogenase activity(GO:0003865) cholestenone 5-alpha-reductase activity(GO:0047751)
0.0	0.1	GO:0003933	GTP cyclohydrolase activity(GO:0003933)
0.0	0.1	GO:0017154	semaphorin receptor activity(GO:0017154)
0.0	0.1	GO:0004438	phosphatidylinositol-3-phosphatase activity(GO:0004438)
0.0	0.1	GO:0031996	thioesterase binding(GO:0031996)
0.0	0.2	GO:0008139	nuclear localization sequence binding(GO:0008139)
0.0	0.0	GO:0004103	choline kinase activity(GO:0004103)
0.0	0.0	GO:0050816	phosphothreonine binding(GO:0050816)
0.0	0.1	GO:0070891	lipoteichoic acid binding(GO:0070891)
0.0	0.1	GO:0098599	palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.1	ST WNT CA2 CYCLIC GMP PATHWAY	Wnt/Ca2+/cyclic GMP signaling.
0.0	0.2	PID NFKAPPAB ATYPICAL PATHWAY	Atypical NF-kappaB pathway
0.0	0.1	PID RANBP2 PATHWAY	Sumoylation by RanBP2 regulates transcriptional repression
0.0	0.2	PID TCR JNK PATHWAY	JNK signaling in the CD4+ TCR pathway
0.0	0.4	NABA BASEMENT MEMBRANES	Genes encoding structural components of basement membranes

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Total log-likelihood	Term	Description
0.1	REACTOME ENDOSOMAL VACUOLAR PATHWAY	Genes involved in Endosomal/Vacuolar pathway
0.2	REACTOME IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION	Genes involved in IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
0.2	REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK	Genes involved in Negative regulation of the PI3K/AKT network
0.2	REACTOME NFKB IS ACTIVATED AND SIGNALS SURVIVAL	Genes involved in NF-kB is activated and signals survival
0.2	REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS	Genes involved in Termination of O-glycan biosynthesis
0.2	REACTOME P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS	Genes involved in p130Cas linkage to MAPK signaling for integrins