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ENCSR904DTN: DNase-seq of mouse liver in constant darkness

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Results for Rest

Z-value: 2.88

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Transcription factors associated with Rest

Gene Symbol	Gene ID	Gene Info
Rest Ensembl NCBI MGI UniProt	ENSMUSG00000029249.9	RE1-silencing transcription factor

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
chr5_77267056_77267224	Rest	944	0.451623	0.96	1.8e-03	Click!
chr5_77266781_77267041	Rest	715	0.567690	0.78	6.4e-02	Click!
chr5_77265048_77265375	Rest	280	0.865173	-0.69	1.3e-01	Click!
chr5_77266106_77266414	Rest	64	0.959682	-0.64	1.7e-01	Click!
chr5_77265452_77265845	Rest	157	0.931221	-0.48	3.3e-01	Click!

Activity of the Rest motif across conditions

Conditions sorted by the z-value of the Rest motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr11_75173089_75173918	4.99	Mir212	microRNA 212	115	0.56
chr18_25668171_25668329	4.35	0710001A04Rik	RIKEN cDNA 0710001A04 gene	45520	0.16
chr4_131115371_131115541	2.81	A930031H19Rik	RIKEN cDNA A930031H19 gene	104982	0.06
chr15_74076059_74076222	2.53	Gm7935	predicted pseudogene 7935	5371	0.24
chr15_84829493_84829651	2.32	Phf21b	PHD finger protein 21B	25538	0.14
chr15_79791641_79791792	2.27	Nptxr	neuronal pentraxin receptor	735	0.49
chr4_140283535_140283688	2.26	Igsf21	immunoglobulin superfamily, member 21	36827	0.14
chr9_40801417_40801568	2.19	Hspa8	heat shock protein 8	31	0.94
chr19_10403213_10403386	2.18	Syt7	synaptotagmin VII	719	0.62
chr1_173361798_173361949	1.97	Cadm3	cell adhesion molecule 3	5760	0.17
chr1_75277299_75277450	1.94	Resp18	regulated endocrine-specific protein 18	910	0.34
chr7_4996598_4996749	1.87	Zfp579	zinc finger protein 579	515	0.52
chr8_14072651_14072815	1.84	Gm45520	predicted gene 45520	4915	0.16
chr6_55108463_55108627	1.81	Crhr2	corticotropin releasing hormone receptor 2	7972	0.19
chr6_113962934_113963105	1.81	Gm15082	predicted gene 15082	25280	0.14
chr4_151604592_151604765	1.79	4930589P08Rik	RIKEN cDNA 4930589P08 gene	228208	0.02
chr9_121791324_121791483	1.77	Hhatl	hedgehog acyltransferase-like	57	0.94
chr19_6427254_6427405	1.68	Nrxn2	neurexin II	594	0.57
chr2_158570467_158570618	1.58	Arhgap40	Rho GTPase activating protein 40	28805	0.1
chr11_118584913_118585075	1.52	Rbfox3	RNA binding protein, fox-1 homolog (C. elegans) 3	15084	0.22
chr9_106889455_106889671	1.49	Manf	mesencephalic astrocyte-derived neurotrophic factor	720	0.47
chr9_21950442_21950600	1.48	Swsap1	SWIM type zinc finger 7 associated protein 1	5234	0.09
chr7_138084146_138084302	1.47	Gm25798	predicted gene, 25798	17315	0.23
chr9_74535088_74535239	1.47	Gm28622	predicted gene 28622	26215	0.2
chr4_107019507_107019668	1.47	Gm12786	predicted gene 12786	2912	0.21
chr11_83421415_83421571	1.44	Gas2l2	growth arrest-specific 2 like 2	7962	0.11
chr7_30484338_30484496	1.44	Nphs1	nephrosis 1, nephrin	498	0.41
chr19_38558935_38559114	1.42	Plce1	phospholipase C, epsilon 1	24344	0.22
chr6_89614766_89614917	1.38	Chchd6	coiled-coil-helix-coiled-coil-helix domain containing 6	19189	0.17
chr15_84853852_84854164	1.35	Phf21b	PHD finger protein 21B	1102	0.45
chr15_89150169_89150320	1.35	Mapk11	mitogen-activated protein kinase 11	616	0.52
chr5_33438295_33438455	1.34	Gm43851	predicted gene 43851	911	0.54
chr7_44770135_44770325	1.28	Vrk3	vaccinia related kinase 3	13244	0.08
chr12_104850467_104850964	1.26	4930408O17Rik	RIKEN cDNA 4930408O17 gene	6656	0.19
chr9_119389058_119389253	1.22	Xylb	xylulokinase homolog (H. influenzae)	10964	0.11
chr4_45844423_45844581	1.20	Stra6l	STRA6-like	4162	0.18
chr10_45546948_45547107	1.20	Gm27731	predicted gene, 27731	9783	0.18
chr13_117604223_117604403	1.19	Hcn1	hyperpolarization activated cyclic nucleotide gated potassium channel 1	1833	0.49
chr7_30434353_30434522	1.19	Gm30646	predicted gene, 30646	1893	0.12
chr4_62257049_62257210	1.12	Slc31a2	solute carrier family 31, member 2	5433	0.16
chr3_19694558_19694716	1.11	Crh	corticotropin releasing hormone	759	0.59
chr5_24357551_24357718	1.10	Kcnh2	potassium voltage-gated channel, subfamily H (eag-related), member 2	6030	0.1
chr1_74066477_74066680	1.07	Tns1	tensin 1	24773	0.17
chr11_83417193_83417347	1.07	Rasl10b	RAS-like, family 10, member B	7198	0.11
chr16_18087231_18087692	1.06	Prodh	proline dehydrogenase	1561	0.29
chr15_72568672_72568828	1.06	Gm49460	predicted gene, 49460	19533	0.2
chr9_122006687_122006862	1.06	Gm47117	predicted gene, 47117	5366	0.11
chr9_20857229_20857389	1.05	Shfl	shiftless antiviral inhibitor of ribosomal frameshifting	11333	0.08
chr12_102550629_102550788	1.03	Chga	chromogranin A	4261	0.19
chr4_115728832_115728993	1.03	Efcab14	EF-hand calcium binding domain 14	8832	0.14
chr9_122116996_122117412	1.02	Snrk	SNF related kinase	62	0.95
chr11_103920773_103920924	1.00	Nsf	N-ethylmaleimide sensitive fusion protein	5303	0.22
chr8_123838618_123838800	0.95	2810455O05Rik	RIKEN cDNA 2810455O05 gene	2076	0.17
chr3_94374766_94374934	0.95	Rorc	RAR-related orphan receptor gamma	2056	0.12
chr11_115374569_115374733	0.91	Hid1	HID1 domain containing	6895	0.09
chr19_44692476_44692627	0.91	Gm26644	predicted gene, 26644	2724	0.24
chr2_109675977_109676138	0.91	Bdnf	brain derived neurotrophic factor	160	0.83
chr19_47016602_47016771	0.90	Nt5c2	5'-nucleotidase, cytosolic II	1533	0.25
chr6_90513392_90513725	0.90	Gm44236	predicted gene, 44236	256	0.88
chr1_127496856_127497018	0.90	Tmem163	transmembrane protein 163	3407	0.32
chr2_180104544_180104879	0.87	Hrh3	histamine receptor H3	223	0.88
chr5_35531711_35531875	0.87	Cpz	carboxypeptidase Z	6095	0.15
chr9_60982764_60983106	0.86	Gm5122	predicted gene 5122	30546	0.14
chr11_74619258_74619412	0.86	Ccdc92b	coiled-coil domain containing 92B	270	0.9
chr3_88220963_88221116	0.85	Gm3764	predicted gene 3764	1625	0.17
chr1_85080827_85081001	0.81	Gm18342	predicted gene, 18342	678	0.51
chr7_4620106_4620257	0.80	Gm44877	predicted gene 44877	6797	0.07
chr6_85927460_85927847	0.78	Nat8b-ps	N-acetyltransferase 8B, pseudogene	5726	0.08
chr7_44593894_44594057	0.77	Kcnc3	potassium voltage gated channel, Shaw-related subfamily, member 3	20	0.93
chr2_178277324_178277480	0.77	Phactr3	phosphatase and actin regulator 3	50154	0.15
chr1_85500331_85500508	0.77	Gm2427	predicted gene 2427	671	0.57
chr1_85179698_85179873	0.76	Gm6264	predicted gene 6264	18922	0.09
chr8_71483947_71484113	0.76	Ano8	anoctamin 8	19	0.94
chr4_140358223_140358381	0.76	Gm13016	predicted gene 13016	22328	0.14
chr2_91110132_91110333	0.76	Mybpc3	myosin binding protein C, cardiac	7912	0.11
chr9_9230047_9230379	0.75	Gm16833	predicted gene, 16833	6075	0.24
chr17_29492005_29492199	0.73	Pim1	proviral integration site 1	94	0.61
chr9_111139563_111139885	0.72	Lrrfip2	leucine rich repeat (in FLII) interacting protein 2	20049	0.15
chr19_42326023_42326184	0.68	Crtac1	cartilage acidic protein 1	38149	0.11
chr11_81486379_81486540	0.67	1700071K01Rik	RIKEN cDNA 1700071K01 gene	87014	0.09
chr2_180756003_180756165	0.66	Slc17a9	solute carrier family 17, member 9	17810	0.1
chr18_54799055_54799220	0.66	Gm33732	predicted gene, 33732	24652	0.16
chr12_8099948_8100109	0.66	Apob	apolipoprotein B	87669	0.08
chr14_32467734_32467885	0.65	Chat	choline acetyltransferase	1820	0.24
chr6_121473169_121473328	0.63	Iqsec3	IQ motif and Sec7 domain 3	375	0.88
chr6_113428446_113428672	0.63	Cidec	cell death-inducing DFFA-like effector c	6054	0.07
chr12_108994751_108994937	0.63	Gm18405	predicted gene, 18405	3193	0.19
chr13_78171316_78171488	0.62	3110006O06Rik	RIKEN cDNA 3110006O06 gene	228	0.9
chr13_55445821_55446370	0.62	Grk6	G protein-coupled receptor kinase 6	634	0.5
chr6_83927539_83927712	0.61	Zfp638	zinc finger protein 638	1230	0.35
chr17_69439256_69439434	0.60	Akain1	A kinase (PRKA) anchor inhibitor 1	19	0.51
chr6_72634309_72634791	0.58	Gm15401	predicted gene 15401	1703	0.17
chr5_141985119_141985282	0.58	Sdk1	sidekick cell adhesion molecule 1	128413	0.06
chr7_57592274_57592432	0.58	Gabrb3	gamma-aminobutyric acid (GABA) A receptor, subunit beta 3	823	0.67
chr15_26309788_26309969	0.58	Marchf11	membrane associated ring-CH-type finger 11	814	0.77
chr11_31888267_31888568	0.57	Cpeb4	cytoplasmic polyadenylation element binding protein 4	15142	0.2
chr9_107486954_107487108	0.57	Cacna2d2	calcium channel, voltage-dependent, alpha 2/delta subunit 2	18573	0.08
chr6_128469552_128469734	0.57	Gm8719	predicted pseudogene 8719	3745	0.1
chr6_33249470_33249649	0.57	Exoc4	exocyst complex component 4	423	0.81
chr8_112128950_112129112	0.56	Gm22827	predicted gene, 22827	66526	0.1
chr11_117872991_117873321	0.55	Tha1	threonine aldolase 1	303	0.79
chr2_26208213_26208385	0.55	Lhx3	LIM homeobox protein 3	10	0.95
chr12_112141395_112141548	0.53	Kif26a	kinesin family member 26A	4737	0.15
chr6_108430619_108430854	0.51	Itpr1	inositol 1,4,5-trisphosphate receptor 1	12859	0.2
chr11_43902830_43903004	0.51	Adra1b	adrenergic receptor, alpha 1b	1707	0.46
chr14_47486187_47486558	0.51	Gm48986	predicted gene, 48986	5196	0.14
chr5_45529813_45529965	0.50	Gm42521	predicted gene 42521	1183	0.35
chr5_110558497_110558658	0.50	Galnt9	polypeptide N-acetylgalactosaminyltransferase 9	14222	0.14
chr4_46992957_46993118	0.49	Gabbr2	gamma-aminobutyric acid (GABA) B receptor, 2	1164	0.45
chr2_120050008_120050173	0.49	Pla2g4b	phospholipase A2, group IVB (cytosolic)	9120	0.11
chr9_110993538_110993895	0.48	Rtp3	receptor transporter protein 3	3133	0.12
chr17_30389798_30389963	0.48	Gm6402	predicted pseudogene 6402	6153	0.19
chr1_60628564_60628727	0.47	Gm23762	predicted gene, 23762	14842	0.14
chr15_78066618_78066776	0.47	A730060N03Rik	RIKEN cDNA A730060N03 gene	53009	0.09
chr18_15434023_15434197	0.47	Aqp4	aquaporin 4	23128	0.2
chr7_30346746_30346906	0.46	4930479H17Rik	RIKEN cDNA 4930479H17 gene	6495	0.07
chr2_43613684_43613852	0.46	Kynu	kynureninase	14153	0.29
chr9_43698520_43698693	0.45	Gm5364	predicted gene 5364	15553	0.14
chr17_15077876_15078027	0.45	Ermard	ER membrane associated RNA degradation	12336	0.15
chr3_94914590_94914772	0.45	Gm26279	predicted gene, 26279	5742	0.11
chr10_80748733_80748893	0.45	Dot1l	DOT1-like, histone H3 methyltransferase (S. cerevisiae)	6393	0.09
chr2_70559621_70559796	0.44	Gad1	glutamate decarboxylase 1	2334	0.22
chr11_116108287_116108624	0.42	Trim47	tripartite motif-containing 47	336	0.77
chr10_79718092_79718250	0.42	Hcn2	hyperpolarization-activated, cyclic nucleotide-gated K+ 2	1537	0.18
chr5_139014946_139015101	0.41	Prkar1b	protein kinase, cAMP dependent regulatory, type I beta	8787	0.18
chr16_5146310_5146979	0.41	Sec14l5	SEC14-like lipid binding 5	465	0.73
chr1_88194822_88195116	0.39	Gm15376	predicted gene 15376	3068	0.09
chr9_29146016_29146172	0.39	Ntm	neurotrimin	36312	0.22
chr13_95782265_95782699	0.39	Iqgap2	IQ motif containing GTPase activating protein 2	18085	0.18
chr2_65619900_65620061	0.39	Scn2a	sodium channel, voltage-gated, type II, alpha	791	0.72
chr16_32914274_32914432	0.38	Lrch3	leucine-rich repeats and calponin homology (CH) domain containing 3	211	0.91
chr2_30065686_30066045	0.38	Set	SET nuclear oncogene	591	0.59
chr7_99699987_99700199	0.37	Slco2b1	solute carrier organic anion transporter family, member 2b1	4284	0.12
chr11_75046982_75047192	0.37	Gm12333	predicted gene 12333	7739	0.13
chr14_122513626_122513788	0.36	Gm18143	predicted gene, 18143	122	0.94
chr1_175665774_175665943	0.36	Chml	choroideremia-like	22495	0.13
chr1_67235018_67235169	0.36	Gm15668	predicted gene 15668	14107	0.22
chr4_117893494_117893672	0.36	Ipo13	importin 13	1531	0.19
chr12_9166308_9166471	0.35	Ttc32	tetratricopeptide repeat domain 32	136361	0.04
chr5_146238766_146238947	0.35	Cdk8	cyclin-dependent kinase 8	7471	0.12
chr15_28024715_28025200	0.35	Trio	triple functional domain (PTPRF interacting)	3	0.98
chr2_79454254_79454412	0.35	Neurod1	neurogenic differentiation 1	2418	0.28
chr4_117850329_117850493	0.34	Slc6a9	solute carrier family 6 (neurotransmitter transporter, glycine), member 9	1041	0.37
chr1_162548031_162548373	0.32	Eef1aknmt	EEF1A lysine and N-terminal methyltransferase	54	0.97
chr4_120126163_120126326	0.31	Hivep3	human immunodeficiency virus type I enhancer binding protein 3	31755	0.17
chr8_69088523_69088826	0.31	Atp6v1b2	ATPase, H+ transporting, lysosomal V1 subunit B2	28	0.91
chr11_119007787_119007988	0.31	Cbx2	chromobox 2	15075	0.15
chr1_85586586_85586850	0.30	Sp110	Sp110 nuclear body protein	2440	0.15
chr11_115258288_115258439	0.29	Gm25837	predicted gene, 25837	5085	0.11
chr7_142387074_142387268	0.29	Ctsd	cathepsin D	648	0.53
chr11_69914167_69914731	0.29	Gps2	G protein pathway suppressor 2	257	0.73
chr13_54371670_54371821	0.28	Cplx2	complexin 2	396	0.83
chr4_63254251_63254424	0.28	Mir455	microRNA 455	2514	0.25
chr19_16447855_16448017	0.28	Gna14	guanine nucleotide binding protein, alpha 14	8636	0.18
chr14_20093617_20093768	0.27	Saysd1	SAYSVFN motif domain containing 1	10509	0.17
chr11_69934461_69934654	0.27	Ybx2	Y box protein 2	1239	0.18
chr6_113881955_113882116	0.26	Atp2b2	ATPase, Ca++ transporting, plasma membrane 2	9335	0.18
chr9_48603402_48603655	0.26	Nnmt	nicotinamide N-methyltransferase	1549	0.47
chr5_123395114_123395623	0.26	Gm15747	predicted gene 15747	304	0.6
chr11_79427788_79427962	0.25	Nf1	neurofibromin 1	20278	0.13
chr4_12906721_12906911	0.25	Triqk	triple QxxK/R motif containing	22	0.99
chr19_31890378_31890565	0.24	A1cf	APOBEC1 complementation factor	21690	0.19
chr11_104114823_104114983	0.24	Crhr1	corticotropin releasing hormone receptor 1	17952	0.21
chr16_45742916_45743108	0.24	Abhd10	abhydrolase domain containing 10	57	0.96
chr9_56508889_56509217	0.23	Gm47175	predicted gene, 47175	2392	0.25
chr16_30266715_30266896	0.23	Cpn2	carboxypeptidase N, polypeptide 2	694	0.61
chr5_24416500_24416681	0.23	Asic3	acid-sensing (proton-gated) ion channel 3	13	0.93
chr11_72608017_72608168	0.22	Ube2g1	ubiquitin-conjugating enzyme E2G 1	773	0.57
chr1_75179893_75180252	0.22	Abcb6	ATP-binding cassette, sub-family B (MDR/TAP), member 6	214	0.81
chr8_119876752_119876924	0.22	Klhl36	kelch-like 36	14566	0.15
chr6_121144204_121144363	0.21	Mical3	microtubule associated monooxygenase, calponin and LIM domain containing 3	13284	0.14
chr2_31641363_31641698	0.21	Gm13425	predicted gene 13425	941	0.35
chr13_113612458_113612853	0.21	Snx18	sorting nexin 18	986	0.54
chr11_110101538_110102129	0.20	Abca8a	ATP-binding cassette, sub-family A (ABC1), member 8a	5855	0.27
chr6_120463585_120463736	0.20	Il17ra	interleukin 17 receptor A	413	0.8
chr1_188118233_188118393	0.20	Gm38315	predicted gene, 38315	42394	0.18
chr2_157913212_157913385	0.20	Vstm2l	V-set and transmembrane domain containing 2-like	1355	0.44
chr2_93906445_93906632	0.20	Gm1335	predicted gene 1335	34340	0.11
chr19_23160573_23160812	0.20	Mir1192	microRNA 1192	11261	0.16
chr10_87528215_87528468	0.19	Pah	phenylalanine hydroxylase	6314	0.21
chr9_121311967_121312154	0.19	Trak1	trafficking protein, kinesin binding 1	2178	0.24
chr8_11478332_11478510	0.18	Rab20	RAB20, member RAS oncogene family	289	0.63
chr3_89764370_89764528	0.18	Chrnb2	cholinergic receptor, nicotinic, beta polypeptide 2 (neuronal)	159	0.92
chr3_107279311_107279673	0.18	Lamtor5	late endosomal/lysosomal adaptor, MAPK and MTOR activator 5	493	0.74
chr13_96962673_96962863	0.18	Gm48597	predicted gene, 48597	11854	0.16
chr12_104025874_104026200	0.18	Gm37496	predicted gene, 37496	1610	0.23
chr2_91921277_91921473	0.18	Gm10805	predicted gene 10805	447	0.72
chr11_16860070_16860314	0.17	Egfr	epidermal growth factor receptor	17958	0.18
chr7_45198547_45198718	0.17	Ccdc155	coiled-coil domain containing 155	6260	0.06
chr4_137676216_137676391	0.17	Rap1gap	Rap1 GTPase-activating protein	4450	0.19
chr17_72837306_72837660	0.16	Ypel5	yippee like 5	53	0.98
chr9_48675246_48675425	0.16	Nnmt	nicotinamide N-methyltransferase	70182	0.11
chr5_100673558_100673901	0.16	Coq2	coenzyme Q2 4-hydroxybenzoate polyprenyltransferase	427	0.78
chr18_61665532_61665824	0.16	Carmn	cardiac mesoderm enhancer-associated non-coding RNA	141	0.92
chr3_28264177_28264328	0.16	Tnik	TRAF2 and NCK interacting kinase	609	0.76
chr10_81419902_81420248	0.16	Mir1191b	microRNA 1191b	3778	0.08
chr17_85877554_85877736	0.15	Gm30117	predicted gene, 30117	50934	0.14
chr17_24876191_24876410	0.15	Igfals	insulin-like growth factor binding protein, acid labile subunit	1356	0.21
chrX_75874057_75874225	0.15	Pls3	plastin 3 (T-isoform)	433	0.81
chr1_92039344_92039495	0.14	Gm37036	predicted gene, 37036	17322	0.19

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of Rest

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.7	2.1	GO:0072318	clathrin coat disassembly(GO:0072318)
0.4	1.7	GO:1903059	regulation of protein lipidation(GO:1903059)
0.3	4.3	GO:0014041	regulation of neuron maturation(GO:0014041)
0.2	1.5	GO:0090385	phagosome-lysosome fusion(GO:0090385)
0.2	0.7	GO:0071314	cellular response to cocaine(GO:0071314)
0.2	0.6	GO:1902630	regulation of membrane hyperpolarization(GO:1902630)
0.2	0.8	GO:0014053	negative regulation of gamma-aminobutyric acid secretion(GO:0014053)
0.2	0.8	GO:0007412	axon target recognition(GO:0007412)
0.2	0.7	GO:2001184	positive regulation of interleukin-12 secretion(GO:2001184)
0.1	1.0	GO:0098598	vocal learning(GO:0042297) imitative learning(GO:0098596) learned vocalization behavior or vocal learning(GO:0098598)
0.1	0.4	GO:0006562	proline catabolic process(GO:0006562)
0.1	0.4	GO:0030421	defecation(GO:0030421)
0.1	0.5	GO:0006566	threonine metabolic process(GO:0006566)
0.1	0.2	GO:0046865	retinol transport(GO:0034633) isoprenoid transport(GO:0046864) terpenoid transport(GO:0046865)
0.1	0.3	GO:0010360	negative regulation of anion channel activity(GO:0010360)
0.1	0.5	GO:0021523	somatic motor neuron differentiation(GO:0021523)
0.1	0.3	GO:0050968	detection of chemical stimulus involved in sensory perception of pain(GO:0050968)
0.1	0.2	GO:0035434	copper ion transmembrane transport(GO:0035434)
0.1	0.3	GO:1902866	regulation of retina development in camera-type eye(GO:1902866)
0.1	0.2	GO:1900738	positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathway(GO:1900738)
0.1	0.2	GO:0019805	quinolinate biosynthetic process(GO:0019805)
0.1	0.5	GO:0031659	positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle(GO:0031659)
0.1	0.2	GO:0001994	norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure(GO:0001994)
0.1	0.5	GO:0048341	paraxial mesoderm formation(GO:0048341)
0.1	0.2	GO:0007529	establishment of synaptic specificity at neuromuscular junction(GO:0007529)
0.1	0.2	GO:0015959	diadenosine polyphosphate metabolic process(GO:0015959)
0.1	0.2	GO:0060084	synaptic transmission involved in micturition(GO:0060084)
0.1	0.2	GO:1904694	negative regulation of vascular smooth muscle contraction(GO:1904694)
0.1	0.2	GO:2000667	positive regulation of interleukin-5 secretion(GO:2000664) positive regulation of interleukin-13 secretion(GO:2000667)
0.0	0.4	GO:0071420	cellular response to histamine(GO:0071420)
0.0	0.3	GO:0048840	otolith development(GO:0048840)
0.0	0.1	GO:0009449	gamma-aminobutyric acid biosynthetic process(GO:0009449)
0.0	0.1	GO:0071873	response to norepinephrine(GO:0071873)
0.0	0.1	GO:0042732	D-xylose metabolic process(GO:0042732)
0.0	0.2	GO:0016139	glycoside catabolic process(GO:0016139)
0.0	0.7	GO:0001976	neurological system process involved in regulation of systemic arterial blood pressure(GO:0001976)
0.0	0.2	GO:0007256	activation of JNKK activity(GO:0007256)
0.0	0.2	GO:0010760	negative regulation of macrophage chemotaxis(GO:0010760)
0.0	0.6	GO:0032012	ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.0	0.2	GO:0015886	heme transport(GO:0015886)
0.0	0.2	GO:0031915	positive regulation of synaptic plasticity(GO:0031915)
0.0	0.1	GO:0014900	regulation of muscle hyperplasia(GO:0014738) muscle hyperplasia(GO:0014900)
0.0	0.1	GO:0001560	regulation of cell growth by extracellular stimulus(GO:0001560)
0.0	0.3	GO:0070269	pyroptosis(GO:0070269)
0.0	0.1	GO:0097623	potassium ion export across plasma membrane(GO:0097623)
0.0	0.2	GO:0021999	neural plate anterior/posterior regionalization(GO:0021999)
0.0	0.1	GO:0036233	glycine import(GO:0036233)
0.0	0.1	GO:0035564	regulation of kidney size(GO:0035564)
0.0	0.1	GO:0017182	peptidyl-diphthamide metabolic process(GO:0017182) peptidyl-diphthamide biosynthetic process from peptidyl-histidine(GO:0017183)
0.0	0.1	GO:1904469	positive regulation of tumor necrosis factor secretion(GO:1904469)
0.0	0.1	GO:0070295	renal water absorption(GO:0070295)
0.0	0.1	GO:0018125	peptidyl-cysteine methylation(GO:0018125)
0.0	0.1	GO:0015816	glycine transport(GO:0015816)
0.0	0.1	GO:0045347	negative regulation of MHC class II biosynthetic process(GO:0045347)
0.0	0.1	GO:0050882	voluntary musculoskeletal movement(GO:0050882)
0.0	0.1	GO:0021586	pons maturation(GO:0021586)
0.0	0.0	GO:0001543	ovarian follicle rupture(GO:0001543)
0.0	0.2	GO:0046085	adenosine metabolic process(GO:0046085)
0.0	0.1	GO:2000338	chemokine (C-X-C motif) ligand 1 production(GO:0072566) regulation of chemokine (C-X-C motif) ligand 1 production(GO:2000338)
0.0	0.0	GO:1903587	regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:1903587)
0.0	0.1	GO:2000591	positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway(GO:0035793) regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway(GO:1900238) positive regulation of metanephric mesenchymal cell migration(GO:2000591)
0.0	0.1	GO:0006528	asparagine metabolic process(GO:0006528)
0.0	0.1	GO:0032482	Rab protein signal transduction(GO:0032482)
0.0	0.1	GO:0090292	nuclear matrix organization(GO:0043578) nuclear matrix anchoring at nuclear membrane(GO:0090292)
0.0	0.0	GO:0033058	directional locomotion(GO:0033058)
0.0	0.1	GO:0060836	lymphatic endothelial cell differentiation(GO:0060836)
0.0	0.1	GO:0033615	mitochondrial proton-transporting ATP synthase complex assembly(GO:0033615)
0.0	0.1	GO:0018879	biphenyl metabolic process(GO:0018879)
0.0	0.1	GO:0006398	mRNA 3'-end processing by stem-loop binding and cleavage(GO:0006398)
0.0	0.0	GO:2000857	positive regulation of mineralocorticoid secretion(GO:2000857) positive regulation of aldosterone secretion(GO:2000860)
0.0	0.1	GO:0060729	intestinal epithelial structure maintenance(GO:0060729)
0.0	0.1	GO:2000852	corticosterone secretion(GO:0035934) regulation of corticosterone secretion(GO:2000852)
0.0	0.1	GO:0010626	negative regulation of Schwann cell proliferation(GO:0010626)
0.0	0.0	GO:0060157	urinary bladder development(GO:0060157)
0.0	0.2	GO:0042407	cristae formation(GO:0042407)
0.0	0.1	GO:0070245	positive regulation of thymocyte apoptotic process(GO:0070245)
0.0	0.1	GO:0090086	negative regulation of protein deubiquitination(GO:0090086)
0.0	0.2	GO:0060052	neurofilament cytoskeleton organization(GO:0060052)
0.0	0.0	GO:0018202	peptidyl-histidine modification(GO:0018202)
0.0	0.2	GO:0001921	positive regulation of receptor recycling(GO:0001921)
0.0	0.0	GO:0032672	regulation of interleukin-3 production(GO:0032672)
0.0	0.1	GO:2000766	negative regulation of cytoplasmic translation(GO:2000766)
0.0	0.1	GO:1900242	regulation of synaptic vesicle endocytosis(GO:1900242)
0.0	0.0	GO:0030240	skeletal muscle thin filament assembly(GO:0030240)
0.0	0.1	GO:0031034	myosin filament assembly(GO:0031034)
0.0	0.0	GO:0061535	glutamate secretion, neurotransmission(GO:0061535)
0.0	0.0	GO:2000686	regulation of rubidium ion transmembrane transporter activity(GO:2000686)
0.0	0.0	GO:0060178	regulation of exocyst localization(GO:0060178)
0.0	0.1	GO:0070493	thrombin receptor signaling pathway(GO:0070493)
0.0	0.0	GO:0045896	regulation of transcription during mitosis(GO:0045896) positive regulation of transcription during mitosis(GO:0045897)
0.0	0.1	GO:0036089	cleavage furrow formation(GO:0036089)
0.0	0.6	GO:0007520	myoblast fusion(GO:0007520)
0.0	0.1	GO:0046668	regulation of retinal cell programmed cell death(GO:0046668)
0.0	0.0	GO:0016554	cytidine to uridine editing(GO:0016554)
0.0	0.1	GO:2000535	entry of bacterium into host cell(GO:0035635) regulation of entry of bacterium into host cell(GO:2000535)
0.0	0.7	GO:0046928	regulation of neurotransmitter secretion(GO:0046928)
0.0	0.2	GO:0030322	stabilization of membrane potential(GO:0030322)
0.0	0.1	GO:0021942	radial glia guided migration of Purkinje cell(GO:0021942)
0.0	0.0	GO:0018094	protein polyglycylation(GO:0018094)
0.0	0.5	GO:0000381	regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.0	0.0	GO:0050883	musculoskeletal movement, spinal reflex action(GO:0050883)
0.0	0.1	GO:2000503	positive regulation of natural killer cell chemotaxis(GO:2000503)
0.0	0.1	GO:0045586	regulation of gamma-delta T cell differentiation(GO:0045586) regulation of gamma-delta T cell activation(GO:0046643)
0.0	0.1	GO:0003418	growth plate cartilage chondrocyte differentiation(GO:0003418)
0.0	0.1	GO:0070914	UV-damage excision repair(GO:0070914)
0.0	0.1	GO:0033030	negative regulation of neutrophil apoptotic process(GO:0033030)
0.0	0.0	GO:0044333	Wnt signaling pathway involved in digestive tract morphogenesis(GO:0044333)
0.0	0.0	GO:0000965	mitochondrial RNA 3'-end processing(GO:0000965)
0.0	0.0	GO:0034729	histone H3-K79 methylation(GO:0034729)
0.0	0.0	GO:0071225	cellular response to muramyl dipeptide(GO:0071225)
0.0	0.0	GO:0002314	germinal center B cell differentiation(GO:0002314)
0.0	0.1	GO:0034145	positive regulation of toll-like receptor 4 signaling pathway(GO:0034145)
0.0	0.0	GO:0048808	male genitalia morphogenesis(GO:0048808) male anatomical structure morphogenesis(GO:0090598)
0.0	0.2	GO:0007214	gamma-aminobutyric acid signaling pathway(GO:0007214)
0.0	0.0	GO:0006106	fumarate metabolic process(GO:0006106)
0.0	0.0	GO:0070634	transepithelial ammonium transport(GO:0070634)
0.0	0.0	GO:0060024	rhythmic synaptic transmission(GO:0060024)
0.0	0.0	GO:1990034	calcium ion export from cell(GO:1990034)
0.0	0.0	GO:1900109	regulation of histone H3-K9 dimethylation(GO:1900109)
0.0	0.0	GO:0090325	regulation of locomotion involved in locomotory behavior(GO:0090325)
0.0	0.3	GO:0001990	regulation of systemic arterial blood pressure by hormone(GO:0001990)
0.0	0.0	GO:0061146	Peyer's patch morphogenesis(GO:0061146)
0.0	0.0	GO:0060061	regulation of collateral sprouting in absence of injury(GO:0048696) Spemann organizer formation(GO:0060061)
0.0	0.1	GO:0046485	ether lipid metabolic process(GO:0046485)
0.0	0.1	GO:2000480	negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
0.0	0.0	GO:0071926	cannabinoid signaling pathway(GO:0038171) endocannabinoid signaling pathway(GO:0071926)
0.0	0.2	GO:0007026	negative regulation of microtubule depolymerization(GO:0007026)
0.0	0.0	GO:0044314	protein K27-linked ubiquitination(GO:0044314)
0.0	0.1	GO:0052697	xenobiotic glucuronidation(GO:0052697)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.4	2.1	GO:0043202	lysosomal lumen(GO:0043202)
0.2	1.4	GO:0032009	early phagosome(GO:0032009)
0.1	0.6	GO:0048237	rough endoplasmic reticulum lumen(GO:0048237)
0.1	0.7	GO:0036056	filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.1	0.6	GO:0032584	growth cone membrane(GO:0032584)
0.1	0.2	GO:0038037	G-protein coupled receptor dimeric complex(GO:0038037) G-protein coupled receptor complex(GO:0097648)
0.1	0.3	GO:0097169	AIM2 inflammasome complex(GO:0097169)
0.1	0.8	GO:0030061	mitochondrial crista(GO:0030061)
0.1	1.0	GO:0043196	varicosity(GO:0043196)
0.1	0.1	GO:0031088	platelet dense granule membrane(GO:0031088)
0.0	0.2	GO:0042583	chromaffin granule(GO:0042583)
0.0	0.2	GO:0070033	synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex(GO:0070033)
0.0	0.2	GO:0061617	MICOS complex(GO:0061617)
0.0	1.3	GO:0032590	dendrite membrane(GO:0032590)
0.0	0.2	GO:0030285	integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.0	0.1	GO:0016533	cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533)
0.0	0.1	GO:0090498	extrinsic component of Golgi membrane(GO:0090498)
0.0	0.1	GO:0005863	striated muscle myosin thick filament(GO:0005863)
0.0	0.1	GO:0030121	AP-1 adaptor complex(GO:0030121)
0.0	0.2	GO:0033180	proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.0	0.1	GO:0071986	Ragulator complex(GO:0071986)
0.0	0.3	GO:1902710	GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711)
0.0	0.2	GO:0005883	neurofilament(GO:0005883)
0.0	1.0	GO:0042734	presynaptic membrane(GO:0042734)
0.0	0.1	GO:0005642	annulate lamellae(GO:0005642)
0.0	0.1	GO:0051286	cell tip(GO:0051286)
0.0	0.1	GO:0033588	Elongator holoenzyme complex(GO:0033588)
0.0	0.1	GO:0034993	microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.0	0.3	GO:0032809	neuronal cell body membrane(GO:0032809)
0.0	0.2	GO:0035102	PRC1 complex(GO:0035102)
0.0	0.1	GO:0000138	Golgi trans cisterna(GO:0000138)
0.0	0.1	GO:1990124	messenger ribonucleoprotein complex(GO:1990124)
0.0	0.0	GO:0034363	intermediate-density lipoprotein particle(GO:0034363)
0.0	0.0	GO:0045098	type III intermediate filament(GO:0045098)
0.0	0.0	GO:0005968	Rab-protein geranylgeranyltransferase complex(GO:0005968)
0.0	0.0	GO:0045293	mRNA editing complex(GO:0045293)
0.0	0.0	GO:0008274	gamma-tubulin large complex(GO:0000931) gamma-tubulin ring complex(GO:0008274)
0.0	0.0	GO:0005775	vacuolar lumen(GO:0005775)
0.0	0.2	GO:0005892	acetylcholine-gated channel complex(GO:0005892)
0.0	0.1	GO:0005952	cAMP-dependent protein kinase complex(GO:0005952)
0.0	0.1	GO:0032593	insulin-responsive compartment(GO:0032593)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.7	2.1	GO:0031686	A1 adenosine receptor binding(GO:0031686)
0.2	0.8	GO:0004969	histamine receptor activity(GO:0004969)
0.2	0.7	GO:0051430	corticotropin-releasing hormone receptor 1 binding(GO:0051430) corticotropin-releasing hormone receptor 2 binding(GO:0051431)
0.1	0.4	GO:0008732	threonine aldolase activity(GO:0004793) L-allo-threonine aldolase activity(GO:0008732)
0.1	0.3	GO:0030899	calcium-dependent ATPase activity(GO:0030899)
0.1	0.7	GO:0005167	neurotrophin TRK receptor binding(GO:0005167)
0.1	0.2	GO:0004937	alpha1-adrenergic receptor activity(GO:0004937)
0.1	0.3	GO:0004703	G-protein coupled receptor kinase activity(GO:0004703)
0.1	0.2	GO:0004965	G-protein coupled GABA receptor activity(GO:0004965)
0.1	0.5	GO:0005222	intracellular cAMP activated cation channel activity(GO:0005222)
0.0	0.1	GO:0016822	hydrolase activity, acting on acid carbon-carbon bonds(GO:0016822) hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances(GO:0016823)
0.0	0.2	GO:0015232	heme transporter activity(GO:0015232)
0.0	0.4	GO:0035612	AP-2 adaptor complex binding(GO:0035612)
0.0	0.7	GO:0017128	phospholipid scramblase activity(GO:0017128)
0.0	0.3	GO:0030368	interleukin-17 receptor activity(GO:0030368)
0.0	0.2	GO:0004791	thioredoxin-disulfide reductase activity(GO:0004791)
0.0	0.1	GO:0008142	oxysterol binding(GO:0008142)
0.0	0.7	GO:0004707	MAP kinase activity(GO:0004707)
0.0	0.4	GO:0043024	ribosomal small subunit binding(GO:0043024)
0.0	0.3	GO:0015280	ligand-gated sodium channel activity(GO:0015280)
0.0	0.1	GO:0015375	glycine:sodium symporter activity(GO:0015375)
0.0	0.1	GO:0031694	alpha-2A adrenergic receptor binding(GO:0031694)
0.0	0.2	GO:0015185	gamma-aminobutyric acid transmembrane transporter activity(GO:0015185)
0.0	0.1	GO:1902282	voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization(GO:1902282)
0.0	0.5	GO:0017160	Ral GTPase binding(GO:0017160)
0.0	0.2	GO:0019957	C-C chemokine binding(GO:0019957)
0.0	0.1	GO:0005220	inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.0	0.1	GO:0034617	tetrahydrobiopterin binding(GO:0034617)
0.0	0.0	GO:0032767	copper-dependent protein binding(GO:0032767)
0.0	0.9	GO:0005246	calcium channel regulator activity(GO:0005246)
0.0	0.9	GO:0030507	spectrin binding(GO:0030507)
0.0	0.1	GO:0008321	Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.0	0.3	GO:0008093	cytoskeletal adaptor activity(GO:0008093)
0.0	0.2	GO:0008599	protein phosphatase type 1 regulator activity(GO:0008599)
0.0	1.5	GO:0005546	phosphatidylinositol-4,5-bisphosphate binding(GO:0005546)
0.0	0.1	GO:0019959	interleukin-8 binding(GO:0019959)
0.0	0.4	GO:0004435	phosphatidylinositol phospholipase C activity(GO:0004435)
0.0	0.0	GO:0070905	serine binding(GO:0070905)
0.0	0.1	GO:0003997	acyl-CoA oxidase activity(GO:0003997)
0.0	0.5	GO:0071949	FAD binding(GO:0071949)
0.0	0.6	GO:0005086	ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.0	0.7	GO:0005251	delayed rectifier potassium channel activity(GO:0005251)
0.0	0.2	GO:0005375	copper ion transmembrane transporter activity(GO:0005375)
0.0	0.2	GO:0043008	ATP-dependent protein binding(GO:0043008)
0.0	0.1	GO:0003847	1-alkyl-2-acetylglycerophosphocholine esterase activity(GO:0003847)
0.0	0.1	GO:0033265	choline binding(GO:0033265)
0.0	0.2	GO:0008253	5'-nucleotidase activity(GO:0008253)
0.0	0.1	GO:0034711	inhibin binding(GO:0034711)
0.0	0.1	GO:0003988	acetyl-CoA C-acyltransferase activity(GO:0003988)
0.0	0.0	GO:0043125	ErbB-3 class receptor binding(GO:0043125)
0.0	0.1	GO:0051525	NFAT protein binding(GO:0051525)
0.0	0.0	GO:0008184	glycogen phosphorylase activity(GO:0008184)
0.0	0.0	GO:0031708	endothelin B receptor binding(GO:0031708)
0.0	0.0	GO:0048408	epidermal growth factor binding(GO:0048408)
0.0	0.1	GO:0000900	translation repressor activity, nucleic acid binding(GO:0000900)
0.0	0.0	GO:0008252	nucleotidase activity(GO:0008252)
0.0	0.2	GO:0022841	potassium ion leak channel activity(GO:0022841)
0.0	0.0	GO:0005223	intracellular cGMP activated cation channel activity(GO:0005223)
0.0	0.3	GO:0042166	acetylcholine binding(GO:0042166)
0.0	0.1	GO:0008603	cAMP-dependent protein kinase regulator activity(GO:0008603)
0.0	0.1	GO:0051425	PTB domain binding(GO:0051425)
0.0	0.1	GO:0031849	olfactory receptor binding(GO:0031849)
0.0	0.0	GO:0004461	lactose synthase activity(GO:0004461)
0.0	0.1	GO:0004468	lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468)
0.0	0.1	GO:0002094	polyprenyltransferase activity(GO:0002094)
0.0	0.1	GO:0032036	myosin heavy chain binding(GO:0032036)
0.0	0.0	GO:0019767	IgE receptor activity(GO:0019767)
0.0	0.1	GO:0016803	ether hydrolase activity(GO:0016803)
0.0	0.0	GO:0018585	fluorene oxygenase activity(GO:0018585)
0.0	0.1	GO:0042577	lipid phosphatase activity(GO:0042577)
0.0	0.0	GO:0071532	ankyrin repeat binding(GO:0071532)
0.0	0.2	GO:0005520	insulin-like growth factor binding(GO:0005520)
0.0	0.4	GO:0017046	peptide hormone binding(GO:0017046)
0.0	0.1	GO:0015168	glycerol transmembrane transporter activity(GO:0015168) glycerol channel activity(GO:0015254)

Gene overrepresentation in curated gene sets: canonical pathways category:

Total log-likelihood	Term	Description
0.7	PID LYMPH ANGIOGENESIS PATHWAY	VEGFR3 signaling in lymphatic endothelium
0.5	PID IL5 PATHWAY	IL5-mediated signaling events
0.6	PID NEPHRIN NEPH1 PATHWAY	Nephrin/Neph1 signaling in the kidney podocyte
1.8	PID SMAD2 3NUCLEAR PATHWAY	Regulation of nuclear SMAD2/3 signaling
0.9	PID SHP2 PATHWAY	SHP2 signaling
0.5	PID INSULIN PATHWAY	Insulin Pathway
0.3	PID NETRIN PATHWAY	Netrin-mediated signaling events
0.3	PID RAS PATHWAY	Regulation of Ras family activation

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	2.0	REACTOME LYSOSOME VESICLE BIOGENESIS	Genes involved in Lysosome Vesicle Biogenesis
0.1	0.7	REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS	Genes involved in Activation of the AP-1 family of transcription factors
0.0	0.8	REACTOME NEPHRIN INTERACTIONS	Genes involved in Nephrin interactions
0.0	0.4	REACTOME GABA A RECEPTOR ACTIVATION	Genes involved in GABA A receptor activation
0.0	0.3	REACTOME DCC MEDIATED ATTRACTIVE SIGNALING	Genes involved in DCC mediated attractive signaling
0.0	1.0	REACTOME AMINE LIGAND BINDING RECEPTORS	Genes involved in Amine ligand-binding receptors
0.0	0.2	REACTOME ABACAVIR TRANSPORT AND METABOLISM	Genes involved in Abacavir transport and metabolism
0.0	0.4	REACTOME INSULIN SYNTHESIS AND PROCESSING	Genes involved in Insulin Synthesis and Processing
0.0	0.2	REACTOME ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE	Genes involved in Acetylcholine Neurotransmitter Release Cycle
0.0	0.2	REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS	Genes involved in Trafficking of GluR2-containing AMPA receptors
0.0	0.2	REACTOME TRYPTOPHAN CATABOLISM	Genes involved in Tryptophan catabolism
0.0	0.3	REACTOME INFLAMMASOMES	Genes involved in Inflammasomes
0.0	0.2	REACTOME RETROGRADE NEUROTROPHIN SIGNALLING	Genes involved in Retrograde neurotrophin signalling
0.0	0.8	REACTOME VOLTAGE GATED POTASSIUM CHANNELS	Genes involved in Voltage gated Potassium channels
0.0	0.3	REACTOME INTERACTION BETWEEN L1 AND ANKYRINS	Genes involved in Interaction between L1 and Ankyrins
0.0	0.2	REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS	Genes involved in Tandem pore domain potassium channels
0.0	0.3	REACTOME PLATELET CALCIUM HOMEOSTASIS	Genes involved in Platelet calcium homeostasis
0.0	0.3	REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS	Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.0	0.2	REACTOME HIGHLY CALCIUM PERMEABLE POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS	Genes involved in Highly calcium permeable postsynaptic nicotinic acetylcholine receptors
0.0	1.0	REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS	Genes involved in Class B/2 (Secretin family receptors)
0.0	0.4	REACTOME LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS	Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis
0.0	0.2	REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS	Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.0	0.5	REACTOME POTASSIUM CHANNELS	Genes involved in Potassium Channels
0.0	0.1	REACTOME DSCAM INTERACTIONS	Genes involved in DSCAM interactions
0.0	0.0	REACTOME MRNA PROCESSING	Genes involved in mRNA Processing
0.0	0.1	REACTOME PASSIVE TRANSPORT BY AQUAPORINS	Genes involved in Passive Transport by Aquaporins

Results for Rest

Z-value: 2.88

Motif logo

Transcription factors associated with Rest

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

Activity of the Rest motif across conditions

Conditions sorted by the z-value of the Rest motif activity

Top target CREs of the motif:

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of Rest

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: