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ENCSR904DTN: DNase-seq of mouse liver in constant darkness

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for Rfx5

Z-value: 0.79

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Transcription factors associated with Rfx5

Gene Symbol	Gene ID	Gene Info
Rfx5 Ensembl NCBI MGI UniProt	ENSMUSG00000005774.6	Rfx5

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

Gene	Promoter	Distance	Association probability	Pearson corr. coef.	P-value	Plot
Rfx5	chr3_94953385_94953872	447	0.655877	-0.78	6.7e-02	Click!
Rfx5	chr3_94945756_94945907	8244	0.088078	0.74	9.4e-02	Click!
Rfx5	chr3_94954465_94954628	19	0.946414	-0.71	1.1e-01	Click!
Rfx5	chr3_94943842_94944021	10144	0.085767	0.53	2.8e-01	Click!
Rfx5	chr3_94950096_94950252	3901	0.105431	-0.45	3.8e-01	Click!

Activity of the Rfx5 motif across conditions

Conditions sorted by the z-value of the Rfx5 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr11_16868019_16868198	0.66	Egfr	epidermal growth factor receptor	10042	0.2
chr13_23299091_23299367	0.63	Gm11333	predicted gene 11333	1180	0.26
chr2_58769900_58770051	0.56	Upp2	uridine phosphorylase 2	4650	0.24
chr7_63922331_63923024	0.56	Klf13	Kruppel-like factor 13	2193	0.22
chr11_16781411_16781603	0.56	Egfr	epidermal growth factor receptor	29277	0.16
chrX_156479377_156479543	0.55	Gm23404	predicted gene, 23404	23365	0.24
chr1_67132947_67133268	0.50	Cps1	carbamoyl-phosphate synthetase 1	10081	0.24
chr13_108367613_108367783	0.47	Depdc1b	DEP domain containing 1B	10272	0.21
chr17_37190817_37190981	0.42	Ubd	ubiquitin D	2993	0.09
chr15_57710929_57711112	0.41	Gm16006	predicted gene 16006	2093	0.32
chr13_107642057_107642316	0.39	Gm32090	predicted gene, 32090	29337	0.18
chr1_41559831_41559986	0.38	Gm28634	predicted gene 28634	30365	0.26
chr17_46053621_46054045	0.38	Vegfa	vascular endothelial growth factor A	21464	0.12
chr17_34153027_34153195	0.37	H2-DMb1	histocompatibility 2, class II, locus Mb1	39	0.92
chr14_65050597_65050753	0.35	Extl3	exostosin-like glycosyltransferase 3	47430	0.13
chr15_3398579_3398730	0.31	Ghr	growth hormone receptor	72990	0.11
chr7_29303739_29303929	0.30	Dpf1	D4, zinc and double PHD fingers family 1	117	0.93
chr11_4195737_4195910	0.30	Tbc1d10a	TBC1 domain family, member 10a	9001	0.1
chr19_38015663_38015814	0.29	Myof	myoferlin	27613	0.14
chr4_76360115_76360401	0.28	Ptprd	protein tyrosine phosphatase, receptor type, D	16015	0.23
chr2_73491256_73491419	0.27	Wipf1	WAS/WASL interacting protein family, member 1	4868	0.19
chr11_16744767_16744918	0.27	Egfr	epidermal growth factor receptor	7361	0.2
chr11_16790428_16790580	0.26	Egfr	epidermal growth factor receptor	38274	0.14
chr8_77045181_77045332	0.26	Nr3c2	nuclear receptor subfamily 3, group C, member 2	82757	0.09
chr11_16893244_16893395	0.26	Egfr	epidermal growth factor receptor	11866	0.19
chr11_16837434_16837735	0.26	Egfros	epidermal growth factor receptor, opposite strand	6882	0.22
chr14_77586069_77586220	0.25	Enox1	ecto-NOX disulfide-thiol exchanger 1	13288	0.18
chr3_50077080_50077240	0.25	Gm37826	predicted gene, 37826	47491	0.16
chr15_59065322_59065483	0.25	Mtss1	MTSS I-BAR domain containing 1	9938	0.23
chr6_142528529_142528737	0.25	Ldhb	lactate dehydrogenase B	20676	0.17
chr15_63155793_63155965	0.24	Gm49013	predicted gene, 49013	9646	0.23
chr2_27770776_27770927	0.24	Rxra	retinoid X receptor alpha	30650	0.2
chr19_8757228_8757608	0.24	Nxf1	nuclear RNA export factor 1	268	0.68
chr5_125483749_125483900	0.24	Gm27551	predicted gene, 27551	4447	0.15
chr3_63317524_63317675	0.24	Mme	membrane metallo endopeptidase	17439	0.25
chr17_34347674_34347859	0.24	H2-Ea	histocompatibility 2, class II antigen E alpha	3121	0.11
chr2_172934925_172935100	0.23	Bmp7	bone morphogenetic protein 7	5080	0.21
chr16_37938812_37938975	0.22	Gpr156	G protein-coupled receptor 156	22397	0.15
chr4_54733994_54734173	0.22	Gm12477	predicted gene 12477	63891	0.11
chr11_16817302_16817617	0.22	Egfros	epidermal growth factor receptor, opposite strand	13243	0.21
chr1_59201583_59201922	0.22	Als2	alsin Rho guanine nucleotide exchange factor	17374	0.14
chr16_78322780_78322958	0.21	Cxadr	coxsackie virus and adenovirus receptor	2338	0.25
chr1_52022235_52022386	0.21	Stat4	signal transducer and activator of transcription 4	13684	0.16
chr3_89142602_89142893	0.21	Pklr	pyruvate kinase liver and red blood cell	6124	0.07
chr15_58957352_58957568	0.20	Mtss1	MTSS I-BAR domain containing 1	620	0.66
chr3_27562067_27562227	0.20	Gm43344	predicted gene 43344	15506	0.22
chr10_50623725_50623913	0.20	Ascc3	activating signal cointegrator 1 complex subunit 3	18623	0.22
chr1_91446944_91447095	0.20	Per2	period circadian clock 2	2846	0.16
chr17_34257684_34257866	0.20	H2-Ab1	histocompatibility 2, class II antigen A, beta 1	86	0.92
chr7_135747212_135747378	0.20	Gm36431	predicted gene, 36431	4619	0.2
chr17_34304881_34305040	0.19	Gm20513	predicted gene 20513	760	0.33
chr17_83057976_83058141	0.19	Gm29052	predicted gene 29052	10847	0.21
chr6_51578310_51578498	0.19	Snx10	sorting nexin 10	33838	0.16
chr17_34305717_34305873	0.19	H2-Eb1	histocompatibility 2, class II antigen E beta	72	0.49
chr10_80679534_80679874	0.19	Mknk2	MAP kinase-interacting serine/threonine kinase 2	1592	0.19
chr6_136553862_136554030	0.19	Atf7ip	activating transcription factor 7 interacting protein	58	0.97
chr4_108119092_108119243	0.19	Scp2	sterol carrier protein 2, liver	635	0.66
chr14_64098292_64098443	0.18	Prss51	protease, serine 51	4641	0.13
chr5_122313082_122313277	0.18	Gm15842	predicted gene 15842	10757	0.1
chr5_53994743_53994917	0.18	Stim2	stromal interaction molecule 2	3669	0.3
chr13_59893097_59893271	0.18	Gm19866	predicted gene, 19866	13935	0.13
chr16_43346186_43346337	0.18	Zbtb20	zinc finger and BTB domain containing 20	16787	0.16
chr6_108638094_108638414	0.18	Gm17055	predicted gene 17055	18663	0.14
chr1_91444586_91444906	0.18	Per2	period circadian clock 2	5119	0.13
chr11_61223499_61223666	0.18	Aldh3a1	aldehyde dehydrogenase family 3, subfamily A1	14837	0.13
chr3_142619782_142619948	0.18	Gbp2	guanylate binding protein 2	737	0.55
chr18_60803553_60803864	0.18	Cd74	CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated)	140	0.94
chr1_150873368_150873519	0.18	Hmcn1	hemicentin 1	119608	0.05
chr5_118649434_118649712	0.18	Gm43274	predicted gene 43274	5200	0.18
chr5_33605422_33605612	0.18	Fam53a	family with sequence similarity 53, member A	23395	0.11
chr1_92937865_92938056	0.18	Capn10	calpain 10	2499	0.15
chr2_45463913_45464105	0.18	Gm13479	predicted gene 13479	106744	0.07
chr10_80668723_80668916	0.18	Mknk2	MAP kinase-interacting serine/threonine kinase 2	3157	0.11
chr1_13467289_13467464	0.17	Gm7593	predicted gene 7593	59721	0.1
chr17_34079687_34079853	0.17	H2-Pb	histocompatibility 2, P region beta locus	3603	0.06
chr11_120806039_120806735	0.17	Fasn	fatty acid synthase	2218	0.14
chr1_45672893_45673066	0.17	Gm23216	predicted gene, 23216	12583	0.19
chr17_84647222_84647423	0.17	Dync2li1	dynein cytoplasmic 2 light intermediate chain 1	1953	0.24
chr16_33932119_33932270	0.17	Itgb5	integrin beta 5	9708	0.17
chr8_69074605_69074774	0.17	Slc18a1	solute carrier family 18 (vesicular monoamine), member 1	819	0.58
chr8_105086546_105086842	0.17	Ces3b	carboxylesterase 3B	1925	0.2
chr19_10067201_10067465	0.16	Fads2	fatty acid desaturase 2	3854	0.16
chr11_48843419_48843570	0.16	Trim7	tripartite motif-containing 7	4408	0.1
chr16_35471313_35471717	0.16	Pdia5	protein disulfide isomerase associated 5	19074	0.14
chr9_74704204_74704355	0.16	Gm27233	predicted gene 27233	4983	0.27
chr3_9610870_9611024	0.16	Zfp704	zinc finger protein 704	862	0.67
chr1_154118196_154118387	0.16	A830008E24Rik	RIKEN cDNA A830008E24 gene	340	0.89
chr7_84129291_84129727	0.15	Abhd17c	abhydrolase domain containing 17C	18306	0.14
chr11_120817967_120818292	0.15	Fasn	fatty acid synthase	2674	0.13
chr14_118008711_118008863	0.15	Dct	dopachrome tautomerase	18748	0.19
chr11_66168455_66168617	0.15	Dnah9	dynein, axonemal, heavy chain 9	3	0.91
chr3_21983890_21984041	0.15	Gm43674	predicted gene 43674	14503	0.21
chr5_92097101_92097294	0.15	G3bp2	GTPase activating protein (SH3 domain) binding protein 2	13478	0.12
chr14_16496682_16496846	0.15	Top2b	topoisomerase (DNA) II beta	71336	0.1
chrX_12042851_12043040	0.15	Bcor	BCL6 interacting corepressor	37608	0.18
chr17_34238737_34238896	0.15	H2-Ob	histocompatibility 2, O region beta locus	87	0.92
chr1_92113054_92113272	0.15	Hdac4	histone deacetylase 4	168	0.97
chr19_29046369_29046553	0.15	1700018L02Rik	RIKEN cDNA 1700018L02 gene	216	0.87
chr8_93190868_93191185	0.15	Gm45909	predicted gene 45909	332	0.84
chr8_70469859_70470010	0.15	Klhl26	kelch-like 26	5964	0.09
chr6_38435070_38435344	0.15	Ubn2	ubinuclein 2	1034	0.47
chr16_5134848_5135218	0.15	Ppl	periplakin	2612	0.19
chr4_122997354_122997619	0.14	Mycl	v-myc avian myelocytomatosis viral oncogene lung carcinoma derived	1387	0.34
chr13_44328539_44328696	0.14	Gm29676	predicted gene, 29676	48168	0.12
chr4_126259234_126259772	0.14	Trappc3	trafficking protein particle complex 3	2822	0.16
chr7_26838778_26838929	0.14	Cyp2a5	cytochrome P450, family 2, subfamily a, polypeptide 5	1615	0.34
chr11_16911280_16911439	0.14	Egfr	epidermal growth factor receptor	6174	0.2
chr16_97511614_97511792	0.14	Fam3b	family with sequence similarity 3, member B	827	0.52
chr12_86512537_86512711	0.14	Esrrb	estrogen related receptor, beta	8215	0.26
chr4_82469279_82469447	0.14	n-R5s188	nuclear encoded rRNA 5S 188	29953	0.16
chr9_69006751_69006913	0.14	Rora	RAR-related orphan receptor alpha	188709	0.03
chr2_132597967_132598125	0.13	AU019990	expressed sequence AU019990	149	0.95
chr6_38637205_38637362	0.13	Klrg2	killer cell lectin-like receptor subfamily G, member 2	41	0.98
chr7_126212979_126213138	0.13	Xpo6	exportin 6	12557	0.12
chr17_34296185_34296361	0.13	H2-Aa	histocompatibility 2, class II antigen A, alpha	8450	0.08
chr15_59027576_59027739	0.13	Mtss1	MTSS I-BAR domain containing 1	12939	0.2
chr14_63411641_63411792	0.13	Blk	B lymphoid kinase	5321	0.16
chr1_67134415_67135075	0.13	Cps1	carbamoyl-phosphate synthetase 1	11719	0.24
chr9_99167096_99167251	0.13	Pik3cb	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta	26552	0.13
chr4_117994950_117995268	0.13	9530034E10Rik	RIKEN cDNA 9530034E10 gene	20073	0.14
chr7_40718144_40718310	0.13	4933402C06Rik	RIKEN cDNA 4933402C06 gene	43490	0.14
chr10_127571278_127571595	0.13	Lrp1	low density lipoprotein receptor-related protein 1	10449	0.1
chr10_89769233_89769434	0.13	Uhrf1bp1l	UHRF1 (ICBP90) binding protein 1-like	17867	0.18
chr10_55257530_55257718	0.13	Gm46190	predicted gene, 46190	133262	0.06
chr14_25793517_25793703	0.13	Gm27185	predicted gene 27185	16271	0.13
chr16_97475742_97475907	0.13	Fam3b	family with sequence similarity 3, member B	483	0.72
chr11_60220800_60221010	0.12	Srebf1	sterol regulatory element binding transcription factor 1	301	0.83
chr10_93899366_93899640	0.12	4930471D02Rik	RIKEN cDNA 4930471D02 gene	2345	0.18
chr6_90553748_90553958	0.12	Aldh1l1	aldehyde dehydrogenase 1 family, member L1	3005	0.19
chr15_3457404_3457613	0.12	Ghr	growth hormone receptor	14136	0.27
chr11_117083257_117083524	0.12	Gm24323	predicted gene, 24323	2446	0.15
chr15_3725358_3725509	0.12	Gm4823	predicted gene 4823	21442	0.25
chr11_16814706_16815122	0.12	Egfros	epidermal growth factor receptor, opposite strand	15788	0.21
chr16_17489651_17490107	0.12	Aifm3	apoptosis-inducing factor, mitochondrion-associated 3	32	0.96
chr7_75686656_75686824	0.12	Akap13	A kinase (PRKA) anchor protein 13	4206	0.2
chr10_53993922_53994073	0.12	Man1a	mannosidase 1, alpha	16882	0.23
chr2_147971964_147972189	0.12	9030622O22Rik	RIKEN cDNA 9030622O22 gene	4109	0.27
chr11_119607460_119607644	0.12	Rptor	regulatory associated protein of MTOR, complex 1	3854	0.21
chr7_97411671_97412103	0.12	Thrsp	thyroid hormone responsive	5632	0.13
chr17_12318423_12318969	0.12	Map3k4	mitogen-activated protein kinase kinase kinase 4	52	0.63
chr2_129865084_129865235	0.12	Stk35	serine/threonine kinase 35	64642	0.1
chr9_96726906_96727072	0.12	Zbtb38	zinc finger and BTB domain containing 38	2047	0.28
chr17_45564691_45565065	0.12	Slc35b2	solute carrier family 35, member B2	139	0.91
chr10_89460914_89461087	0.12	Gas2l3	growth arrest-specific 2 like 3	17033	0.22
chr6_49977860_49978030	0.12	Gm3455	predicted gene 3455	73241	0.11
chr10_104423272_104423453	0.12	Gm22945	predicted gene, 22945	47845	0.17
chr1_191721016_191721195	0.12	Lpgat1	lysophosphatidylglycerol acyltransferase 1	2584	0.25
chr17_26633881_26634242	0.12	Ergic1	endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1	1962	0.24
chr6_24599661_24599829	0.12	Lmod2	leiomodin 2 (cardiac)	1983	0.26
chr18_60804947_60805111	0.12	Cd74	CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated)	1124	0.38
chr9_118101918_118102083	0.11	Azi2	5-azacytidine induced gene 2	42944	0.13
chr1_31034685_31034850	0.11	Gm28644	predicted gene 28644	7152	0.17
chr18_12825759_12825954	0.11	Osbpl1a	oxysterol binding protein-like 1A	5949	0.2
chr12_72955142_72955307	0.11	Gm38170	predicted gene, 38170	4329	0.17
chr16_93819131_93819299	0.11	Dop1b	DOP1 leucine zipper like protein B	9781	0.13
chr2_79986893_79987051	0.11	Pde1a	phosphodiesterase 1A, calmodulin-dependent	52057	0.17
chr16_43328614_43329118	0.11	Gm15711	predicted gene 15711	16272	0.16
chr3_10041035_10041365	0.11	Gm38335	predicted gene, 38335	15661	0.15
chr17_46129789_46130129	0.11	Mrps18a	mitochondrial ribosomal protein S18A	4501	0.12
chr7_67371889_67372064	0.11	Mef2a	myocyte enhancer factor 2A	851	0.44
chr11_119222151_119222324	0.11	Tbc1d16	TBC1 domain family, member 16	261	0.85
chr6_145866005_145866307	0.11	Bhlhe41	basic helix-loop-helix family, member e41	598	0.7
chr9_46015412_46015589	0.11	Sik3	SIK family kinase 3	2500	0.2
chr3_119589038_119589201	0.11	Gm23432	predicted gene, 23432	49755	0.16
chr1_82189665_82189841	0.11	Gm9747	predicted gene 9747	43359	0.14
chr1_74807385_74807536	0.11	Wnt10a	wingless-type MMTV integration site family, member 10A	14097	0.11
chr5_66011974_66012125	0.11	9130230L23Rik	RIKEN cDNA 9130230L23 gene	7764	0.12
chr17_84984575_84984726	0.11	Ppm1b	protein phosphatase 1B, magnesium dependent, beta isoform	9023	0.18
chr7_126280513_126280705	0.11	Sbk1	SH3-binding kinase 1	7209	0.12
chr2_84639968_84640170	0.11	Ctnnd1	catenin (cadherin associated protein), delta 1	1964	0.19
chr18_65154932_65155123	0.10	Nedd4l	neural precursor cell expressed, developmentally down-regulated gene 4-like	707	0.74
chr15_38569128_38569424	0.10	Gm29697	predicted gene, 29697	4720	0.14
chr13_46164802_46165009	0.10	Gm10113	predicted gene 10113	26141	0.22
chr4_108090689_108090857	0.10	Mir6397	microRNA 6397	3416	0.18
chr4_102517129_102517286	0.10	Pde4b	phosphodiesterase 4B, cAMP specific	46810	0.19
chr10_68150861_68151038	0.10	Arid5b	AT rich interactive domain 5B (MRF1-like)	14323	0.25
chr19_60757781_60757932	0.10	Nanos1	nanos C2HC-type zinc finger 1	1869	0.23
chr14_70629530_70629690	0.10	Dmtn	dematin actin binding protein	544	0.65
chr4_129229573_129229757	0.10	C77080	expressed sequence C77080	1754	0.25
chr19_16579816_16579981	0.10	Gm50363	predicted gene, 50363	7430	0.23
chr2_26461392_26461595	0.10	Notch1	notch 1	1254	0.26
chr6_51698327_51698491	0.10	Gm38811	predicted gene, 38811	12672	0.24
chr8_95850398_95850569	0.10	Slc38a7	solute carrier family 38, member 7	3039	0.13
chr12_16586552_16586706	0.10	Lpin1	lipin 1	3091	0.3
chr7_34265793_34265944	0.10	4931406P16Rik	RIKEN cDNA 4931406P16 gene	8649	0.1
chr3_97225695_97225846	0.10	Bcl9	B cell CLL/lymphoma 9	1561	0.36
chr2_167300044_167300203	0.10	B4galt5	UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 5	5575	0.18
chr17_34285962_34286127	0.10	H2-Aa	histocompatibility 2, class II antigen A, alpha	1733	0.17
chr6_88898420_88898581	0.10	Mcm2	minichromosome maintenance complex component 2	177	0.91
chr5_54007502_54007692	0.10	Stim2	stromal interaction molecule 2	9032	0.25
chr15_29977118_29977282	0.10	Gm24554	predicted gene, 24554	26934	0.14
chr17_47009170_47009329	0.10	Ubr2	ubiquitin protein ligase E3 component n-recognin 2	1230	0.43
chr12_77500760_77500939	0.10	Gm48177	predicted gene, 48177	25549	0.17
chr18_75190731_75190882	0.10	Gm8807	predicted gene 8807	7992	0.23
chr12_81190858_81191019	0.10	Mir3067	microRNA 3067	24787	0.17
chr6_17463758_17464495	0.10	Met	met proto-oncogene	19	0.98
chr11_81413147_81413311	0.10	4930527B05Rik	RIKEN cDNA 4930527B05 gene	28216	0.24
chr4_135326152_135326330	0.10	Srrm1	serine/arginine repetitive matrix 1	982	0.41
chr1_31051365_31051516	0.10	Gm28644	predicted gene 28644	9521	0.17
chr17_45642163_45642318	0.09	Capn11	calpain 11	17057	0.09

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of Rfx5

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	0.5	GO:1903800	positive regulation of production of miRNAs involved in gene silencing by miRNA(GO:1903800)
0.1	0.3	GO:0002339	B cell selection(GO:0002339)
0.1	0.2	GO:0002581	negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II(GO:0002581)
0.1	0.8	GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II(GO:0019886)
0.1	0.2	GO:2001013	epithelial cell proliferation involved in renal tubule morphogenesis(GO:2001013)
0.0	0.1	GO:0032377	regulation of intracellular lipid transport(GO:0032377) regulation of intracellular sterol transport(GO:0032380) regulation of intracellular cholesterol transport(GO:0032383)
0.0	0.1	GO:0003062	regulation of heart rate by chemical signal(GO:0003062)
0.0	0.2	GO:0019856	'de novo' pyrimidine nucleobase biosynthetic process(GO:0006207) pyrimidine nucleobase biosynthetic process(GO:0019856)
0.0	0.1	GO:0014854	response to inactivity(GO:0014854) response to muscle inactivity(GO:0014870) response to muscle inactivity involved in regulation of muscle adaptation(GO:0014877) response to denervation involved in regulation of muscle adaptation(GO:0014894)
0.0	0.1	GO:0072338	creatinine metabolic process(GO:0046449) cellular lactam metabolic process(GO:0072338)
0.0	0.1	GO:1901078	negative regulation of relaxation of muscle(GO:1901078)
0.0	0.2	GO:0045647	negative regulation of erythrocyte differentiation(GO:0045647)
0.0	0.2	GO:0002576	platelet degranulation(GO:0002576)
0.0	0.0	GO:0021847	ventricular zone neuroblast division(GO:0021847)
0.0	0.1	GO:0018992	germ-line sex determination(GO:0018992)
0.0	0.1	GO:0051581	negative regulation of neurotransmitter uptake(GO:0051581) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612)
0.0	0.1	GO:2001032	regulation of double-strand break repair via nonhomologous end joining(GO:2001032)
0.0	0.1	GO:0060665	regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling(GO:0060665)
0.0	0.1	GO:0060687	regulation of branching involved in prostate gland morphogenesis(GO:0060687)
0.0	0.1	GO:1901341	activation of store-operated calcium channel activity(GO:0032237) positive regulation of store-operated calcium channel activity(GO:1901341)
0.0	0.0	GO:0006808	regulation of nitrogen utilization(GO:0006808)
0.0	0.1	GO:1903300	negative regulation of glucokinase activity(GO:0033132) negative regulation of hexokinase activity(GO:1903300)
0.0	0.1	GO:0015868	purine ribonucleotide transport(GO:0015868)
0.0	0.1	GO:0043097	pyrimidine-containing compound salvage(GO:0008655) pyrimidine nucleoside salvage(GO:0043097)
0.0	0.0	GO:0070375	ERK5 cascade(GO:0070375)
0.0	0.0	GO:0045726	positive regulation of integrin biosynthetic process(GO:0045726)
0.0	0.0	GO:2000259	positive regulation of complement activation(GO:0045917) positive regulation of protein activation cascade(GO:2000259)
0.0	0.1	GO:1902626	assembly of large subunit precursor of preribosome(GO:1902626)
0.0	0.0	GO:2001184	positive regulation of interleukin-12 secretion(GO:2001184)
0.0	0.0	GO:2000741	positive regulation of mesenchymal stem cell differentiation(GO:2000741)
0.0	0.0	GO:0042126	nitrate metabolic process(GO:0042126)
0.0	0.1	GO:0006268	DNA unwinding involved in DNA replication(GO:0006268)
0.0	0.1	GO:0001834	trophectodermal cell proliferation(GO:0001834)
0.0	0.1	GO:2001286	regulation of caveolin-mediated endocytosis(GO:2001286)
0.0	0.1	GO:0006307	DNA dealkylation involved in DNA repair(GO:0006307)
0.0	0.2	GO:0045898	regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045898)
0.0	0.1	GO:0098904	regulation of AV node cell action potential(GO:0098904)
0.0	0.0	GO:0000087	mitotic M phase(GO:0000087)
0.0	0.2	GO:0016973	poly(A)+ mRNA export from nucleus(GO:0016973)
0.0	0.0	GO:0071596	ubiquitin-dependent protein catabolic process via the N-end rule pathway(GO:0071596)
0.0	0.0	GO:1990705	cholangiocyte proliferation(GO:1990705)
0.0	0.0	GO:0019244	lactate biosynthetic process from pyruvate(GO:0019244) lactate biosynthetic process(GO:0019249)
0.0	0.1	GO:0010944	negative regulation of transcription by competitive promoter binding(GO:0010944)
0.0	0.0	GO:0060509	Type I pneumocyte differentiation(GO:0060509)
0.0	0.0	GO:0021699	cerebellar cortex maturation(GO:0021699)
0.0	0.0	GO:1904479	negative regulation of intestinal absorption(GO:1904479)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	0.5	GO:0097487	multivesicular body, internal vesicle(GO:0097487)
0.1	1.3	GO:0042613	MHC class II protein complex(GO:0042613)
0.0	0.1	GO:0031315	extrinsic component of mitochondrial outer membrane(GO:0031315)
0.0	0.1	GO:0045098	type III intermediate filament(GO:0045098)
0.0	0.2	GO:0042405	nuclear inclusion body(GO:0042405)
0.0	0.0	GO:0034666	integrin alpha2-beta1 complex(GO:0034666)
0.0	0.2	GO:0071565	nBAF complex(GO:0071565)
0.0	0.2	GO:0005641	nuclear envelope lumen(GO:0005641)
0.0	0.1	GO:0020005	symbiont-containing vacuole membrane(GO:0020005)
0.0	0.1	GO:0005664	origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
0.0	0.0	GO:0008282	ATP-sensitive potassium channel complex(GO:0008282)
0.0	0.0	GO:0036454	insulin-like growth factor binding protein complex(GO:0016942) growth factor complex(GO:0036454) insulin-like growth factor ternary complex(GO:0042567)
0.0	0.1	GO:0014731	spectrin-associated cytoskeleton(GO:0014731)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	0.5	GO:0048408	epidermal growth factor binding(GO:0048408)
0.1	0.2	GO:0016743	carboxyl- or carbamoyltransferase activity(GO:0016743)
0.1	0.2	GO:0042289	MHC class II protein binding(GO:0042289)
0.0	0.1	GO:0070538	oleic acid binding(GO:0070538)
0.0	0.5	GO:0023026	MHC class II protein complex binding(GO:0023026)
0.0	0.3	GO:1990405	protein antigen binding(GO:1990405)
0.0	0.2	GO:0001025	RNA polymerase III transcription factor binding(GO:0001025)
0.0	0.1	GO:0015222	serotonin transmembrane transporter activity(GO:0015222)
0.0	0.0	GO:0017098	sulfonylurea receptor binding(GO:0017098)
0.0	0.1	GO:0070644	vitamin D response element binding(GO:0070644)
0.0	0.1	GO:0000295	adenine nucleotide transmembrane transporter activity(GO:0000295) purine ribonucleotide transmembrane transporter activity(GO:0005346) purine nucleotide transmembrane transporter activity(GO:0015216)
0.0	0.1	GO:0043426	MRF binding(GO:0043426)
0.0	0.0	GO:0038181	bile acid receptor activity(GO:0038181)
0.0	0.1	GO:0004849	uridine kinase activity(GO:0004849)
0.0	0.0	GO:0005128	erythropoietin receptor binding(GO:0005128)
0.0	0.1	GO:0052760	4-methyloctanoyl-CoA dehydrogenase activity(GO:0034580) naphthyl-2-methyl-succinyl-CoA dehydrogenase activity(GO:0034845) 2-methylhexanoyl-CoA dehydrogenase activity(GO:0034916) propionyl-CoA dehydrogenase activity(GO:0043820) thiol-driven fumarate reductase activity(GO:0043830) coenzyme F420-dependent 2,4,6-trinitrophenol reductase activity(GO:0052758) coenzyme F420-dependent 2,4,6-trinitrophenol hydride reductase activity(GO:0052759) coenzyme F420-dependent 2,4-dinitrophenol reductase activity(GO:0052760)
0.0	0.0	GO:0045504	dynein heavy chain binding(GO:0045504)
0.0	0.0	GO:0004965	G-protein coupled GABA receptor activity(GO:0004965)
0.0	0.1	GO:0003688	DNA replication origin binding(GO:0003688)
0.0	0.1	GO:0034056	estrogen response element binding(GO:0034056)
0.0	0.2	GO:0003785	actin monomer binding(GO:0003785)
0.0	0.1	GO:0016724	ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.0	0.1	GO:0047760	butyrate-CoA ligase activity(GO:0047760)
0.0	0.1	GO:0086080	protein binding involved in heterotypic cell-cell adhesion(GO:0086080)
0.0	0.1	GO:0019871	sodium channel inhibitor activity(GO:0019871)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.5	PID ERBB NETWORK PATHWAY	ErbB receptor signaling network
0.0	0.1	PID RANBP2 PATHWAY	Sumoylation by RanBP2 regulates transcriptional repression

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Total log-likelihood	Term	Description
0.5	REACTOME SHC1 EVENTS IN EGFR SIGNALING	Genes involved in SHC1 events in EGFR signaling
0.2	REACTOME ALPHA LINOLENIC ACID ALA METABOLISM	Genes involved in alpha-linolenic acid (ALA) metabolism
0.1	REACTOME CIRCADIAN CLOCK	Genes involved in Circadian Clock