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ENCSR904DTN: DNase-seq of mouse liver in constant darkness

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Results for Runx1

Z-value: 0.97

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Transcription factors associated with Runx1

Gene Symbol	Gene ID	Gene Info
Runx1 Ensembl NCBI MGI UniProt	ENSMUSG00000022952.10	runt related transcription factor 1

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
chr16_92698486_92698672	Runx1	1251	0.565237	-0.74	9.2e-02	Click!
chr16_92715564_92715731	Runx1	18319	0.239675	-0.63	1.8e-01	Click!
chr16_92697311_92697473	Runx1	64	0.982897	0.47	3.4e-01	Click!
chr16_92696728_92696879	Runx1	522	0.845725	0.25	6.4e-01	Click!
chr16_92826008_92826183	Runx1	21	0.984518	0.23	6.7e-01	Click!

Activity of the Runx1 motif across conditions

Conditions sorted by the z-value of the Runx1 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr19_27176664_27176830	0.51	Gm35438	predicted gene, 35438	15262	0.21
chr8_111821313_111821477	0.46	Cfdp1	craniofacial development protein 1	32896	0.13
chr5_66114850_66115151	0.42	Rbm47	RNA binding motif protein 47	16809	0.11
chr13_59893097_59893271	0.36	Gm19866	predicted gene, 19866	13935	0.13
chr13_44293994_44294145	0.36	Gm29676	predicted gene, 29676	13620	0.2
chr6_55138486_55138637	0.35	Crhr2	corticotropin releasing hormone receptor 2	5545	0.18
chr5_144126093_144126244	0.33	Gm26925	predicted gene, 26925	14396	0.14
chr6_127265923_127266082	0.31	Gm43635	predicted gene 43635	11358	0.12
chr9_94993733_94993884	0.30	Gm47168	predicted gene, 47168	1124	0.65
chr9_30887209_30887384	0.29	Adamts15	a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 15	22361	0.2
chr18_39251064_39251253	0.29	Arhgap26	Rho GTPase activating protein 26	23790	0.21
chr19_8228991_8229142	0.29	Slc22a29	solute carrier family 22. member 29	10166	0.16
chr5_148936597_148936854	0.28	Katnal1	katanin p60 subunit A-like 1	7405	0.1
chr7_115686790_115686973	0.28	Sox6	SRY (sex determining region Y)-box 6	24516	0.27
chr2_132639230_132639433	0.28	AU019990	expressed sequence AU019990	6550	0.14
chr2_4318191_4318342	0.27	Gm36988	predicted gene, 36988	1787	0.31
chr19_26748788_26748982	0.27	Smarca2	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2	353	0.9
chr14_66199873_66200054	0.26	Ptk2b	PTK2 protein tyrosine kinase 2 beta	13589	0.19
chr6_89213939_89214095	0.25	Gm839	predicted gene 839	2220	0.22
chr2_68884019_68884170	0.25	Gm37159	predicted gene, 37159	7272	0.15
chr2_102901417_102901572	0.25	Cd44	CD44 antigen	1	0.98
chr13_36324738_36325087	0.25	Fars2	phenylalanine-tRNA synthetase 2 (mitochondrial)	2046	0.39
chr4_99028512_99028838	0.24	Angptl3	angiopoietin-like 3	2279	0.28
chr1_45826928_45827079	0.24	Wdr75	WD repeat domain 75	4445	0.16
chr15_3533289_3533452	0.24	Ghr	growth hormone receptor	48472	0.16
chr1_51881730_51881907	0.23	Gm28323	predicted gene 28323	2210	0.25
chr19_26754124_26754675	0.23	Smarca2	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2	799	0.69
chr2_14130166_14130332	0.23	Stam	signal transducing adaptor molecule (SH3 domain and ITAM motif) 1	595	0.69
chr9_41073606_41073757	0.22	Ubash3b	ubiquitin associated and SH3 domain containing, B	5825	0.19
chr1_35889876_35890029	0.22	1110002O04Rik	RIKEN cDNA 1110002O04 gene	10107	0.21
chr18_61719777_61719946	0.22	Grpel2	GrpE-like 2, mitochondrial	639	0.59
chr4_41493635_41493797	0.22	Myorg	myogenesis regulating glycosidase (putative)	8952	0.1
chr14_51105673_51105825	0.22	Eddm3b	epididymal protein 3B	8677	0.08
chr8_115761720_115761892	0.22	Maf	avian musculoaponeurotic fibrosarcoma oncogene homolog	54012	0.15
chr11_84476404_84476555	0.22	Aatf	apoptosis antagonizing transcription factor	15071	0.21
chr11_38681374_38681545	0.21	Gm23520	predicted gene, 23520	116818	0.07
chr15_10972894_10973115	0.21	Amacr	alpha-methylacyl-CoA racemase	8752	0.15
chr6_88995214_88995375	0.21	4933427D06Rik	RIKEN cDNA 4933427D06 gene	44611	0.12
chr1_128016251_128016402	0.21	Zranb3	zinc finger, RAN-binding domain containing 3	2367	0.22
chr3_108134800_108134966	0.21	Gnai3	guanine nucleotide binding protein (G protein), alpha inhibiting 3	11263	0.09
chr8_86538609_86538876	0.21	Abcc12	ATP-binding cassette, sub-family C (CFTR/MRP), member 12	3995	0.27
chr13_8591659_8591833	0.20	Gm48262	predicted gene, 48262	38726	0.19
chr2_101797736_101797887	0.19	Prr5l	proline rich 5 like	78	0.98
chr1_106231521_106231673	0.19	Gm38235	predicted gene, 38235	12283	0.21
chr13_85126680_85126842	0.19	Gm4076	predicted gene 4076	753	0.65
chr6_128646065_128646273	0.19	Gm5884	predicted pseudogene 5884	1256	0.23
chr19_43949859_43950010	0.19	Dnmbp	dynamin binding protein	9743	0.13
chr14_76310421_76310583	0.19	2900040C04Rik	RIKEN cDNA 2900040C04 gene	59045	0.12
chr13_100849368_100849536	0.19	Gm29502	predicted gene 29502	2019	0.24
chr18_12230939_12231163	0.19	Npc1	NPC intracellular cholesterol transporter 1	5275	0.17
chr3_59114068_59114252	0.19	Gpr171	G protein-coupled receptor 171	12339	0.16
chr17_31473791_31473953	0.19	Pde9a	phosphodiesterase 9A	2820	0.14
chr7_122665413_122665987	0.19	Cacng3	calcium channel, voltage-dependent, gamma subunit 3	4792	0.21
chr11_106366472_106366631	0.19	Prr29	proline rich 29	1079	0.4
chr1_138967552_138967703	0.19	Dennd1b	DENN/MADD domain containing 1B	93	0.91
chr9_83102256_83102418	0.18	Gm38398	predicted gene, 38398	4113	0.16
chr5_51969354_51969505	0.18	Gm43175	predicted gene 43175	58498	0.11
chr4_105104623_105104776	0.18	Prkaa2	protein kinase, AMP-activated, alpha 2 catalytic subunit	5191	0.29
chr4_86664611_86664778	0.18	Plin2	perilipin 2	1031	0.52
chr11_90371567_90371726	0.18	Hlf	hepatic leukemia factor	10289	0.26
chr17_13402789_13403038	0.18	Gm8597	predicted gene 8597	1278	0.29
chr1_128008626_128008793	0.18	Zranb3	zinc finger, RAN-binding domain containing 3	9984	0.14
chr18_63463560_63463749	0.18	Gm23581	predicted gene, 23581	44515	0.11
chr2_48766708_48766859	0.18	Gm13489	predicted gene 13489	43772	0.17
chr13_56354793_56354953	0.18	Gm10782	predicted gene 10782	8027	0.15
chr19_3293245_3293431	0.17	Mir6984	microRNA 6984	4418	0.12
chr4_34901497_34901795	0.17	Cga	glycoprotein hormones, alpha subunit	7858	0.13
chr7_4080638_4080789	0.17	Lair1	leukocyte-associated Ig-like receptor 1	17509	0.09
chr17_28696762_28696938	0.17	Mapk14	mitogen-activated protein kinase 14	4282	0.15
chr3_148423494_148423648	0.17	Gm43576	predicted gene 43576	31370	0.22
chr1_84241089_84241262	0.17	Mir6353	microRNA 6353	22214	0.2
chr18_38631612_38631778	0.17	9630014M24Rik	RIKEN cDNA 9630014M24 gene	4408	0.19
chr7_125574044_125574195	0.17	Gm44876	predicted gene 44876	2002	0.27
chr10_80017491_80017661	0.17	Arhgap45	Rho GTPase activating protein 45	660	0.46
chr2_133427180_133427333	0.17	A430048G15Rik	RIKEN cDNA A430048G15 gene	4839	0.26
chr16_4405370_4405807	0.17	Adcy9	adenylate cyclase 9	13999	0.21
chr4_149282398_149282549	0.17	Kif1b	kinesin family member 1B	25033	0.13
chr19_36732071_36732380	0.17	Ppp1r3c	protein phosphatase 1, regulatory subunit 3C	4428	0.24
chr16_31584525_31584676	0.17	Gm34256	predicted gene, 34256	8620	0.17
chr15_93517178_93517343	0.17	Prickle1	prickle planar cell polarity protein 1	2263	0.39
chr9_102410773_102410941	0.16	Gm22894	predicted gene, 22894	37739	0.13
chr3_115789167_115789324	0.16	Gm9889	predicted gene 9889	74095	0.08
chr14_7821426_7821604	0.16	Flnb	filamin, beta	3558	0.19
chr14_66660586_66660748	0.16	Adra1a	adrenergic receptor, alpha 1a	25111	0.21
chr6_142451263_142451444	0.16	Gys2	glycogen synthase 2	21756	0.15
chr1_140183261_140183634	0.16	Cfh	complement component factor h	36	0.98
chr12_111435070_111435221	0.16	Gm10425	predicted gene 10425	4199	0.14
chr7_28049499_28049670	0.16	Psmc4	proteasome (prosome, macropain) 26S subunit, ATPase, 4	464	0.71
chr8_116872866_116873031	0.16	Cmc2	COX assembly mitochondrial protein 2	21576	0.18
chr18_61374503_61374706	0.16	Gm25301	predicted gene, 25301	23209	0.12
chr4_89162623_89162774	0.16	Gm12607	predicted gene 12607	507	0.72
chr19_31896057_31896235	0.16	Gm19241	predicted gene, 19241	17498	0.2
chr12_84034323_84034494	0.16	Acot4	acyl-CoA thioesterase 4	3971	0.1
chr15_66942451_66942629	0.15	Ndrg1	N-myc downstream regulated gene 1	5939	0.18
chr8_115980743_115980903	0.15	Gm45733	predicted gene 45733	8752	0.32
chr8_115719399_115719579	0.15	Maf	avian musculoaponeurotic fibrosarcoma oncogene homolog	11695	0.23
chr1_184605964_184606231	0.15	Rpl21-ps1	ribosomal protein 21, pseudogene 1	11151	0.15
chr17_88625924_88626075	0.15	Ston1	stonin 1	556	0.73
chr18_75377563_75377744	0.15	Smad7	SMAD family member 7	2739	0.29
chr18_20552765_20552968	0.15	Tpi-rs10	triosephosphate isomerase related sequence 10	3502	0.21
chr7_100937600_100937760	0.15	Arhgef17	Rho guanine nucleotide exchange factor (GEF) 17	5573	0.15
chr1_31019080_31019348	0.15	4931428L18Rik	RIKEN cDNA 4931428L18 gene	19310	0.13
chr8_122012297_122012477	0.15	Banp	BTG3 associated nuclear protein	11540	0.14
chr14_63223276_63223490	0.15	Gata4	GATA binding protein 4	9776	0.16
chr9_74790782_74790933	0.15	Gm22315	predicted gene, 22315	8787	0.19
chr16_34083289_34083602	0.15	Kalrn	kalirin, RhoGEF kinase	12542	0.25
chr18_16750214_16750554	0.15	Gm15485	predicted gene 15485	21651	0.21
chr14_62329558_62329856	0.15	Rnaseh2b	ribonuclease H2, subunit B	2361	0.32
chr2_122256732_122256883	0.15	Sord	sorbitol dehydrogenase	22058	0.09
chr11_97920651_97920808	0.15	Gm22461	predicted gene, 22461	21011	0.1
chr14_73116983_73117184	0.15	Rcbtb2	regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2	5954	0.23
chr11_80453320_80453471	0.15	Psmd11	proteasome (prosome, macropain) 26S subunit, non-ATPase, 11	2973	0.25
chr6_139839930_139840114	0.15	Pik3c2g	phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma	1423	0.45
chr18_80275077_80275246	0.15	Slc66a2	solute carrier family 66 member 2	12321	0.11
chr3_36854068_36854318	0.15	4932438A13Rik	RIKEN cDNA 4932438A13 gene	8911	0.21
chr13_51149822_51150173	0.15	Spin1	spindlin 1	15678	0.17
chr12_105686564_105686722	0.15	Gskip	GSK3B interacting protein	1242	0.32
chr1_118458813_118459291	0.15	Gm22710	predicted gene, 22710	213	0.44
chr9_114112478_114112646	0.15	AC157997.1	cartilage associated protein (Crtap) pseudogene	4115	0.21
chr18_35740040_35740191	0.15	Sting1	stimulator of interferon response cGAMP interactor 1	90	0.94
chr5_91274508_91274681	0.14	Gm19619	predicted gene, 19619	8827	0.24
chr17_32347830_32347981	0.14	Akap8l	A kinase (PRKA) anchor protein 8-like	2601	0.17
chr2_34544709_34544892	0.14	Gm13408	predicted gene 13408	20199	0.2
chr5_103848915_103849118	0.14	Klhl8	kelch-like 8	25353	0.14
chr7_73426374_73426525	0.14	Gm44645	predicted gene 44645	4199	0.14
chr3_96528686_96528855	0.14	Hjv	hemojuvelin BMP co-receptor	3598	0.09
chr17_70847152_70847479	0.14	Tgif1	TGFB-induced factor homeobox 1	145	0.92
chr9_74793041_74793363	0.14	Gm22315	predicted gene, 22315	11132	0.18
chr8_3247329_3247509	0.14	Gm16180	predicted gene 16180	12285	0.19
chr6_15728953_15729104	0.14	Mdfic	MyoD family inhibitor domain containing	1229	0.59
chr1_194482743_194482912	0.14	Plxna2	plexin A2	135391	0.05
chr1_91245290_91245453	0.14	Ube2f	ubiquitin-conjugating enzyme E2F (putative)	4933	0.17
chr11_100935486_100935649	0.14	Stat3	signal transducer and activator of transcription 3	3813	0.17
chr6_31198025_31198176	0.14	Lncpint	long non-protein coding RNA, Trp53 induced transcript	18266	0.14
chr2_157819087_157819264	0.14	Ctnnbl1	catenin, beta like 1	29311	0.17
chr11_106742585_106742746	0.14	Pecam1	platelet/endothelial cell adhesion molecule 1	7963	0.11
chr16_43448600_43448866	0.14	Gm15713	predicted gene 15713	28537	0.18
chr10_99314465_99314820	0.14	B530045E10Rik	RIKEN cDNA B530045E10 gene	15476	0.14
chr8_128481354_128481549	0.14	Nrp1	neuropilin 1	122054	0.05
chr19_31896808_31896966	0.14	Gm19241	predicted gene, 19241	16757	0.2
chr7_7281443_7281594	0.14	Gm45844	predicted gene 45844	3229	0.12
chr2_65547147_65547392	0.14	Scn3a	sodium channel, voltage-gated, type III, alpha	17865	0.21
chr3_95523824_95523997	0.14	Ctss	cathepsin S	2876	0.14
chr16_31048299_31048452	0.14	Xxylt1	xyloside xylosyltransferase 1	13052	0.19
chr19_55195901_55196052	0.14	Mir6715	microRNA 6715	3298	0.21
chr5_75320369_75320658	0.14	Gm18345	predicted gene, 18345	21930	0.17
chr9_114924578_114924744	0.14	Gpd1l	glycerol-3-phosphate dehydrogenase 1-like	5307	0.22
chr10_59901049_59901200	0.14	Dnajb12	DnaJ heat shock protein family (Hsp40) member B12	21498	0.14
chr2_60181625_60181942	0.14	Baz2b	bromodomain adjacent to zinc finger domain, 2B	27376	0.13
chr6_8416975_8417147	0.14	Umad1	UMAP1-MVP12 associated (UMA) domain containing 1	2617	0.24
chr5_34574967_34575118	0.14	Gm42867	predicted gene 42867	46	0.91
chr10_86990632_86990973	0.14	Gm16269	predicted gene 16269	9495	0.15
chr8_68020941_68021106	0.13	Gm22018	predicted gene, 22018	10683	0.24
chr19_23024753_23025259	0.13	Gm50136	predicted gene, 50136	36448	0.17
chr5_149160390_149160713	0.13	Gm8615	predicted pseudogene 8615	4342	0.1
chr9_40330530_40330684	0.13	1700110K17Rik	RIKEN cDNA 1700110K17 gene	2867	0.15
chr8_95800469_95800620	0.13	4930513N10Rik	RIKEN cDNA 4930513N10 gene	6200	0.09
chr1_132384418_132384569	0.13	Gm15849	predicted gene 15849	3364	0.17
chr8_11323805_11323964	0.13	Col4a1	collagen, type IV, alpha 1	11058	0.16
chr8_109579164_109579323	0.13	Hp	haptoglobin	71	0.96
chr3_97076477_97076637	0.13	4930573H18Rik	RIKEN cDNA 4930573H18 gene	16228	0.15
chr9_113118608_113118982	0.13	Gm36251	predicted gene, 36251	4234	0.32
chr8_26697737_26697895	0.13	Gm32098	predicted gene, 32098	29510	0.14
chrX_169269868_169270019	0.13	Hccs	holocytochrome c synthetase	50337	0.13
chr9_41938128_41938279	0.13	Sorl1	sortilin-related receptor, LDLR class A repeats-containing	36384	0.13
chr2_84996477_84996638	0.13	Prg3	proteoglycan 3	8342	0.12
chrX_52140432_52140583	0.13	Gpc4	glypican 4	24745	0.24
chr4_130774522_130774687	0.13	Gm23711	predicted gene, 23711	1137	0.34
chr10_58370276_58370427	0.13	Lims1	LIM and senescent cell antigen-like domains 1	1103	0.51
chr1_83900189_83900548	0.13	4933436I20Rik	RIKEN cDNA 4933436I20 gene	11203	0.23
chr16_95383459_95383635	0.13	Gm31641	predicted gene, 31641	27871	0.2
chr6_128503302_128503638	0.12	Pzp	PZP, alpha-2-macroglobulin like	8247	0.09
chr4_150434207_150434380	0.12	Rere	arginine glutamic acid dipeptide (RE) repeats	27899	0.2
chr19_32627970_32628365	0.12	Papss2	3'-phosphoadenosine 5'-phosphosulfate synthase 2	8162	0.23
chr10_117677088_117677246	0.12	Cpm	carboxypeptidase M	1274	0.36
chr2_128266444_128266595	0.12	Morrbid	myeloid RNA regulator of BCL2L11 induced cell death	25834	0.2
chr1_152573046_152573282	0.12	Rgl1	ral guanine nucleotide dissociation stimulator,-like 1	19595	0.23
chr9_119983098_119983399	0.12	1700019L13Rik	RIKEN cDNA 1700019L13 gene	31	0.73
chr2_131330687_131330851	0.12	Rnf24	ring finger protein 24	1781	0.25
chr5_143492763_143492920	0.12	Daglb	diacylglycerol lipase, beta	6163	0.13
chr11_61273784_61273967	0.12	Aldh3a2	aldehyde dehydrogenase family 3, subfamily A2	6411	0.17
chr8_8959238_8959490	0.12	Gm44515	predicted gene 44515	26665	0.21
chr16_23144476_23144635	0.12	Adipoq	adiponectin, C1Q and collagen domain containing	1981	0.13
chr9_116847373_116847540	0.12	Rbms3	RNA binding motif, single stranded interacting protein	24637	0.27
chr4_118033071_118033392	0.12	St3gal3	ST3 beta-galactoside alpha-2,3-sialyltransferase 3	1349	0.44
chr4_35101216_35101367	0.12	Ifnk	interferon kappa	50765	0.12
chr19_55808091_55808481	0.12	Ppnr	per-pentamer repeat gene	33386	0.21
chr16_97281118_97281506	0.12	Bace2	beta-site APP-cleaving enzyme 2	75430	0.1
chr7_65802914_65803076	0.12	1810008I18Rik	RIKEN cDNA 1810008I18 gene	116	0.96
chr3_10007581_10007909	0.12	Fabp5	fatty acid binding protein 5, epidermal	4803	0.19
chr6_70814231_70814401	0.12	Rpia	ribose 5-phosphate isomerase A	22084	0.13
chr16_34826235_34826441	0.12	Mylk	myosin, light polypeptide kinase	41417	0.17
chr17_34896533_34896711	0.12	C2	complement component 2 (within H-2S)	1065	0.19
chr13_98917969_98918176	0.12	Tnpo1	transportin 1	8282	0.14
chr8_110822079_110822262	0.12	Il34	interleukin 34	16246	0.1
chr7_121836969_121837120	0.12	Gm44740	predicted gene 44740	2021	0.31
chr15_27782797_27782987	0.12	Trio	triple functional domain (PTPRF interacting)	5746	0.25
chr1_160980118_160980282	0.12	Serpinc1	serine (or cysteine) peptidase inhibitor, clade C (antithrombin), member 1	1512	0.18
chr4_55354398_55354553	0.12	Rad23b	RAD23 homolog B, nucleotide excision repair protein	4385	0.18
chr16_6039608_6039759	0.11	1700123O21Rik	RIKEN cDNA 1700123O21 gene	64098	0.15

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of Runx1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:0035887	aortic smooth muscle cell differentiation(GO:0035887)
0.1	0.3	GO:2000562	negative regulation of CD4-positive, alpha-beta T cell proliferation(GO:2000562)
0.0	0.1	GO:0031914	negative regulation of synaptic plasticity(GO:0031914)
0.0	0.2	GO:0002591	positive regulation of antigen processing and presentation of peptide antigen via MHC class I(GO:0002591)
0.0	0.1	GO:0016554	cytidine to uridine editing(GO:0016554)
0.0	0.1	GO:0009115	xanthine catabolic process(GO:0009115)
0.0	0.2	GO:1903551	regulation of extracellular exosome assembly(GO:1903551)
0.0	0.1	GO:0071225	cellular response to muramyl dipeptide(GO:0071225)
0.0	0.1	GO:0010727	negative regulation of hydrogen peroxide metabolic process(GO:0010727)
0.0	0.1	GO:0034197	acylglycerol transport(GO:0034196) triglyceride transport(GO:0034197)
0.0	0.1	GO:0006566	threonine metabolic process(GO:0006566)
0.0	0.1	GO:0097195	pilomotor reflex(GO:0097195)
0.0	0.1	GO:2001013	epithelial cell proliferation involved in renal tubule morphogenesis(GO:2001013)
0.0	0.1	GO:2000346	negative regulation of hepatocyte proliferation(GO:2000346)
0.0	0.1	GO:0006432	phenylalanyl-tRNA aminoacylation(GO:0006432)
0.0	0.1	GO:0034436	glycoprotein transport(GO:0034436)
0.0	0.1	GO:0019254	carnitine metabolic process, CoA-linked(GO:0019254)
0.0	0.1	GO:0030421	defecation(GO:0030421)
0.0	0.1	GO:0061368	behavioral response to chemical pain(GO:0061366) behavioral response to formalin induced pain(GO:0061368)
0.0	0.1	GO:0000720	pyrimidine dimer repair by nucleotide-excision repair(GO:0000720)
0.0	0.2	GO:0035745	T-helper 2 cell cytokine production(GO:0035745)
0.0	0.1	GO:1902071	regulation of hypoxia-inducible factor-1alpha signaling pathway(GO:1902071)
0.0	0.1	GO:0015879	carnitine transport(GO:0015879)
0.0	0.1	GO:0051005	negative regulation of lipoprotein lipase activity(GO:0051005)
0.0	0.1	GO:1901844	regulation of cell communication by electrical coupling involved in cardiac conduction(GO:1901844)
0.0	0.1	GO:0048478	replication fork protection(GO:0048478)
0.0	0.1	GO:0010916	regulation of very-low-density lipoprotein particle clearance(GO:0010915) negative regulation of very-low-density lipoprotein particle clearance(GO:0010916)
0.0	0.1	GO:0035021	negative regulation of Rac protein signal transduction(GO:0035021)
0.0	0.1	GO:0021778	oligodendrocyte cell fate specification(GO:0021778) oligodendrocyte cell fate commitment(GO:0021779) glial cell fate specification(GO:0021780)
0.0	0.1	GO:0090038	negative regulation of protein kinase C signaling(GO:0090038)
0.0	0.1	GO:1904059	regulation of locomotor rhythm(GO:1904059)
0.0	0.0	GO:0034421	post-translational protein acetylation(GO:0034421)
0.0	0.1	GO:0048387	negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.0	0.0	GO:0045630	positive regulation of T-helper 2 cell differentiation(GO:0045630)
0.0	0.0	GO:1903800	positive regulation of production of miRNAs involved in gene silencing by miRNA(GO:1903800)
0.0	0.1	GO:0001561	fatty acid alpha-oxidation(GO:0001561)
0.0	0.1	GO:0006083	acetate metabolic process(GO:0006083)
0.0	0.1	GO:0023021	termination of signal transduction(GO:0023021)
0.0	0.0	GO:2000698	positive regulation of epithelial cell differentiation involved in kidney development(GO:2000698)
0.0	0.1	GO:0070295	renal water absorption(GO:0070295)
0.0	0.0	GO:0045200	establishment or maintenance of neuroblast polarity(GO:0045196) establishment of neuroblast polarity(GO:0045200)
0.0	0.0	GO:0010694	positive regulation of alkaline phosphatase activity(GO:0010694)
0.0	0.0	GO:0007354	zygotic determination of anterior/posterior axis, embryo(GO:0007354)
0.0	0.0	GO:0015860	purine nucleoside transmembrane transport(GO:0015860) purine-containing compound transmembrane transport(GO:0072530) nucleoside transmembrane transport(GO:1901642)
0.0	0.0	GO:0046684	response to pyrethroid(GO:0046684)
0.0	0.1	GO:0051890	regulation of cardioblast differentiation(GO:0051890)
0.0	0.1	GO:0006957	complement activation, alternative pathway(GO:0006957)
0.0	0.0	GO:1904179	positive regulation of adipose tissue development(GO:1904179)
0.0	0.0	GO:1904016	response to Thyroglobulin triiodothyronine(GO:1904016) cellular response to Thyroglobulin triiodothyronine(GO:1904017)
0.0	0.1	GO:0070236	negative regulation of activation-induced cell death of T cells(GO:0070236)
0.0	0.1	GO:0035589	G-protein coupled purinergic nucleotide receptor signaling pathway(GO:0035589)
0.0	0.0	GO:0003289	atrial septum primum morphogenesis(GO:0003289)
0.0	0.0	GO:0050747	positive regulation of lipoprotein metabolic process(GO:0050747)
0.0	0.1	GO:0042985	negative regulation of amyloid precursor protein biosynthetic process(GO:0042985)
0.0	0.0	GO:0003284	septum primum development(GO:0003284)
0.0	0.0	GO:0009233	menaquinone metabolic process(GO:0009233)
0.0	0.1	GO:2000169	regulation of peptidyl-cysteine S-nitrosylation(GO:2000169)
0.0	0.0	GO:0021699	cerebellar cortex maturation(GO:0021699)
0.0	0.1	GO:0045899	positive regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045899)
0.0	0.0	GO:0003431	growth plate cartilage chondrocyte development(GO:0003431)
0.0	0.1	GO:0042795	snRNA transcription from RNA polymerase II promoter(GO:0042795)
0.0	0.0	GO:0002337	B-1a B cell differentiation(GO:0002337)
0.0	0.0	GO:0035754	B cell chemotaxis(GO:0035754)
0.0	0.0	GO:0030091	protein repair(GO:0030091)
0.0	0.0	GO:0032789	saturated monocarboxylic acid metabolic process(GO:0032788) unsaturated monocarboxylic acid metabolic process(GO:0032789)
0.0	0.0	GO:0050427	3'-phosphoadenosine 5'-phosphosulfate metabolic process(GO:0050427)
0.0	0.0	GO:0018879	biphenyl metabolic process(GO:0018879)
0.0	0.0	GO:0007597	blood coagulation, intrinsic pathway(GO:0007597)
0.0	0.1	GO:0060916	mesenchymal cell proliferation involved in lung development(GO:0060916)
0.0	0.0	GO:0032430	positive regulation of phospholipase A2 activity(GO:0032430)
0.0	0.0	GO:0042668	auditory receptor cell fate determination(GO:0042668)
0.0	0.1	GO:0070493	thrombin receptor signaling pathway(GO:0070493)
0.0	0.0	GO:2001170	negative regulation of ATP biosynthetic process(GO:2001170)
0.0	0.1	GO:0071557	histone H3-K27 demethylation(GO:0071557)

Gene overrepresentation in cellular component category:

Total log-likelihood	Term	Description
0.4	GO:0071564	npBAF complex(GO:0071564)
0.1	GO:0031838	haptoglobin-hemoglobin complex(GO:0031838)
0.2	GO:0031932	TORC2 complex(GO:0031932)
0.2	GO:0046581	intercellular canaliculus(GO:0046581)
0.1	GO:0031088	platelet dense granule membrane(GO:0031088)
0.1	GO:0031595	nuclear proteasome complex(GO:0031595)
0.0	GO:0032937	SREBP-SCAP-Insig complex(GO:0032937)
0.0	GO:0070522	ERCC4-ERCC1 complex(GO:0070522)
0.1	GO:1990462	omegasome(GO:1990462)
0.0	GO:0005899	insulin receptor complex(GO:0005899)
0.1	GO:0031983	vesicle lumen(GO:0031983)
0.0	GO:0032299	ribonuclease H2 complex(GO:0032299)
0.1	GO:0045293	mRNA editing complex(GO:0045293)
0.1	GO:0070652	HAUS complex(GO:0070652)
0.0	GO:1990907	beta-catenin-TCF complex(GO:1990907)
0.0	GO:0009331	glycerol-3-phosphate dehydrogenase complex(GO:0009331)

Gene overrepresentation in molecular function category:

Total log-likelihood	Term	Description
0.2	GO:0005114	type II transforming growth factor beta receptor binding(GO:0005114)
0.2	GO:0008559	xenobiotic-transporting ATPase activity(GO:0008559)
0.1	GO:0004793	threonine aldolase activity(GO:0004793) L-allo-threonine aldolase activity(GO:0008732)
0.1	GO:0016726	xanthine dehydrogenase activity(GO:0004854) oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor(GO:0016726)
0.1	GO:0042895	antibiotic transporter activity(GO:0042895)
0.1	GO:0003987	acetate-CoA ligase activity(GO:0003987)
0.1	GO:0036402	proteasome-activating ATPase activity(GO:0036402)
0.1	GO:0070991	medium-chain-acyl-CoA dehydrogenase activity(GO:0070991)
0.1	GO:0070538	oleic acid binding(GO:0070538)
0.1	GO:0000774	adenyl-nucleotide exchange factor activity(GO:0000774)
0.1	GO:0030229	very-low-density lipoprotein particle receptor activity(GO:0030229)
0.0	GO:0005072	transforming growth factor beta receptor, cytoplasmic mediator activity(GO:0005072)
0.1	GO:0004826	phenylalanine-tRNA ligase activity(GO:0004826)
0.1	GO:0030492	hemoglobin binding(GO:0030492)
0.2	GO:0070410	co-SMAD binding(GO:0070410)
0.1	GO:0060230	lipoprotein lipase activator activity(GO:0060230)
0.0	GO:0043423	3-phosphoinositide-dependent protein kinase binding(GO:0043423)
0.1	GO:0004127	cytidylate kinase activity(GO:0004127)
0.0	GO:0005006	epidermal growth factor-activated receptor activity(GO:0005006)
0.0	GO:0015119	hexose phosphate transmembrane transporter activity(GO:0015119) organophosphate:inorganic phosphate antiporter activity(GO:0015315) hexose-phosphate:inorganic phosphate antiporter activity(GO:0015526) glucose 6-phosphate:inorganic phosphate antiporter activity(GO:0061513)
0.0	GO:0004937	alpha1-adrenergic receptor activity(GO:0004937)
0.2	GO:0001846	opsonin binding(GO:0001846)
0.0	GO:0070699	type II activin receptor binding(GO:0070699)
0.1	GO:0050700	CARD domain binding(GO:0050700)
0.1	GO:0004046	aminoacylase activity(GO:0004046)
0.1	GO:0030957	Tat protein binding(GO:0030957)
0.1	GO:0071933	Arp2/3 complex binding(GO:0071933)
0.4	GO:0001105	RNA polymerase II transcription coactivator activity(GO:0001105)
0.1	GO:0016936	galactoside binding(GO:0016936)
0.0	GO:0052622	4-hydroxybenzoate octaprenyltransferase activity(GO:0008412) protoheme IX farnesyltransferase activity(GO:0008495) (S)-2,3-di-O-geranylgeranylglyceryl phosphate synthase activity(GO:0043888) cadaverine aminopropyltransferase activity(GO:0043918) agmatine aminopropyltransferase activity(GO:0043919) 1,4-dihydroxy-2-naphthoate octaprenyltransferase activity(GO:0046428) trans-pentaprenyltranstransferase activity(GO:0048045) ATP dimethylallyltransferase activity(GO:0052622) ADP dimethylallyltransferase activity(GO:0052623)
0.0	GO:0003986	acetyl-CoA hydrolase activity(GO:0003986)
0.1	GO:0071558	histone demethylase activity (H3-K27 specific)(GO:0071558)
0.0	GO:0051525	NFAT protein binding(GO:0051525)
0.0	GO:0001075	transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly(GO:0001075)
0.1	GO:0043426	MRF binding(GO:0043426)
0.0	GO:0005347	ATP transmembrane transporter activity(GO:0005347)
0.0	GO:0008321	Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.1	GO:0035005	1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.0	GO:0003953	NAD+ nucleosidase activity(GO:0003953)
0.2	GO:0030159	receptor signaling complex scaffold activity(GO:0030159)
0.0	GO:0004367	glycerol-3-phosphate dehydrogenase [NAD+] activity(GO:0004367)
0.1	GO:0045028	G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.1	GO:0005041	low-density lipoprotein receptor activity(GO:0005041)
0.0	GO:0051032	nucleic acid transmembrane transporter activity(GO:0051032) RNA transmembrane transporter activity(GO:0051033)
0.1	GO:0004859	phospholipase inhibitor activity(GO:0004859)
0.0	GO:0061629	RNA polymerase II sequence-specific DNA binding transcription factor binding(GO:0061629)

Gene overrepresentation in curated gene sets: canonical pathways category:

Total log-likelihood	Term	Description
0.0	PID P38 ALPHA BETA PATHWAY	Regulation of p38-alpha and p38-beta
0.3	SA MMP CYTOKINE CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.0	PID P38 GAMMA DELTA PATHWAY	Signaling mediated by p38-gamma and p38-delta

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Total log-likelihood	Term	Description
0.3	REACTOME HYALURONAN UPTAKE AND DEGRADATION	Genes involved in Hyaluronan uptake and degradation
0.0	REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK	Genes involved in Negative regulation of the PI3K/AKT network
0.1	REACTOME REGULATION OF COMPLEMENT CASCADE	Genes involved in Regulation of Complement cascade
0.2	REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY	Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.1	REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24 HYDROXYCHOLESTEROL	Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol

Results for Runx1

Z-value: 0.97

Motif logo

Transcription factors associated with Runx1

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

Activity of the Runx1 motif across conditions

Conditions sorted by the z-value of the Runx1 motif activity

Top target CREs of the motif:

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of Runx1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: