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ENCSR904DTN: DNase-seq of mouse liver in constant darkness

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for Runx3

Z-value: 2.00

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Transcription factors associated with Runx3

Gene Symbol	Gene ID	Gene Info
Runx3 Ensembl NCBI MGI UniProt	ENSMUSG00000070691.4	Runx3

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

Gene	Promoter	Distance	Association probability	Pearson corr. coef.	P-value	Plot
Runx3	chr4_135204278_135204439	49922	0.096326	0.75	8.8e-02	Click!
Runx3	chr4_135203380_135204093	49300	0.097535	0.58	2.3e-01	Click!
Runx3	chr4_135206185_135206602	51957	0.092384	0.56	2.5e-01	Click!

Activity of the Runx3 motif across conditions

Conditions sorted by the z-value of the Runx3 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr12_109993740_109993939	1.94	Gm34667	predicted gene, 34667	30034	0.1
chr16_21613201_21613352	1.53	Vps8	VPS8 CORVET complex subunit	5430	0.27
chr12_41247016_41247167	1.17	Gm47376	predicted gene, 47376	100999	0.07
chr15_102192910_102193280	0.98	Csad	cysteine sulfinic acid decarboxylase	1036	0.35
chr9_103066985_103067146	0.92	Gm47468	predicted gene, 47468	18461	0.14
chr10_7976561_7976927	0.91	Tab2	TGF-beta activated kinase 1/MAP3K7 binding protein 2	20514	0.19
chr13_93621073_93621244	0.90	Gm15622	predicted gene 15622	4224	0.19
chr3_123104065_123104239	0.90	Synpo2	synaptopodin 2	8658	0.16
chr10_95544966_95545117	0.88	Ube2n	ubiquitin-conjugating enzyme E2N	3528	0.16
chr2_77155937_77156088	0.88	Ccdc141	coiled-coil domain containing 141	14564	0.21
chr15_99093772_99093973	0.81	Dnajc22	DnaJ heat shock protein family (Hsp40) member C22	702	0.47
chr6_88717841_88718269	0.80	Mgll	monoglyceride lipase	6357	0.14
chr2_103600397_103600730	0.80	Abtb2	ankyrin repeat and BTB (POZ) domain containing 2	34253	0.15
chr7_81542702_81542853	0.80	Gm37829	predicted gene, 37829	10256	0.1
chr4_86664611_86664778	0.74	Plin2	perilipin 2	1031	0.52
chr6_85803570_85803735	0.74	Nat8f6	N-acetyltransferase 8 (GCN5-related) family member 6	6211	0.09
chr5_9103732_9103883	0.72	Tmem243	transmembrane protein 243, mitochondrial	3060	0.23
chr7_80666924_80667352	0.72	Crtc3	CREB regulated transcription coactivator 3	21739	0.15
chr6_85702238_85702435	0.70	Nat8f7	N-acetyltransferase 8 (GCN5-related) family member 7	5522	0.12
chr4_46657221_46657388	0.67	Tbc1d2	TBC1 domain family, member 2	7095	0.21
chr16_50764320_50764471	0.65	1700116B05Rik	RIKEN cDNA 1700116B05 gene	19014	0.18
chr15_82455207_82455652	0.60	Cyp2d9	cytochrome P450, family 2, subfamily d, polypeptide 9	141	0.87
chr5_120566729_120566934	0.60	2510016D11Rik	RIKEN cDNA 2510016D11 gene	13792	0.09
chr2_161090855_161091012	0.59	Chd6	chromodomain helicase DNA binding protein 6	18071	0.18
chr7_35802685_35802845	0.59	E130304I02Rik	RIKEN cDNA E130304I02 gene	172	0.52
chr4_100401449_100401626	0.58	Gm12706	predicted gene 12706	39478	0.18
chr15_82397705_82398277	0.58	Cyp2d11	cytochrome P450, family 2, subfamily d, polypeptide 11	3969	0.07
chr1_39545677_39545839	0.57	Snord89	small nucleolar RNA, C/D box 89	3096	0.14
chr18_20980846_20980997	0.57	Rnf125	ring finger protein 125	19449	0.18
chr11_67526441_67526592	0.57	Gas7	growth arrest specific 7	20638	0.21
chr8_71535881_71536032	0.57	Bst2	bone marrow stromal cell antigen 2	1375	0.2
chr2_172477517_172477864	0.57	Fam209	family with sequence similarity 209	5170	0.15
chr16_17885845_17885996	0.56	Dgcr2	DiGeorge syndrome critical region gene 2	5673	0.09
chr18_63597933_63598104	0.56	Gm24848	predicted gene, 24848	13282	0.18
chr5_125137828_125138031	0.55	Ncor2	nuclear receptor co-repressor 2	13029	0.2
chr11_70409620_70409854	0.53	Pelp1	proline, glutamic acid and leucine rich protein 1	291	0.78
chr4_101416398_101416601	0.53	Ak4	adenylate kinase 4	2778	0.2
chr7_49633783_49633973	0.53	Dbx1	developing brain homeobox 1	2971	0.33
chr1_182602082_182602275	0.53	Capn8	calpain 8	37140	0.13
chr15_80711397_80711548	0.52	Tnrc6b	trinucleotide repeat containing 6b	159	0.88
chr4_155320479_155320646	0.51	Prkcz	protein kinase C, zeta	19391	0.14
chr15_10953321_10953904	0.51	C1qtnf3	C1q and tumor necrosis factor related protein 3	1255	0.4
chr1_193617502_193617686	0.51	Mir205hg	Mir205 host gene	107420	0.06
chr2_126574664_126574815	0.50	Slc27a2	solute carrier family 27 (fatty acid transporter), member 2	9979	0.18
chr17_24470568_24470947	0.50	Pgp	phosphoglycolate phosphatase	322	0.51
chr6_5190649_5191077	0.50	Pon1	paraoxonase 1	2900	0.26
chr15_36471981_36472313	0.50	Ankrd46	ankyrin repeat domain 46	24568	0.12
chr8_109705135_109705296	0.49	Zfp821	zinc finger protein 821	331	0.85
chr5_135090387_135090722	0.49	Mlxipl	MLX interacting protein-like	664	0.5
chr12_26398692_26398891	0.48	Rnf144a	ring finger protein 144A	7656	0.16
chr13_98946494_98946645	0.48	Gm35215	predicted gene, 35215	653	0.6
chr14_73630476_73630939	0.47	Gm21750	predicted gene, 21750	30518	0.15
chr13_119966643_119967735	0.47	Gm20784	predicted gene, 20784	4945	0.11
chr9_48826985_48827136	0.47	Zbtb16	zinc finger and BTB domain containing 16	8885	0.24
chr11_60728592_60728763	0.46	Mir5100	microRNA 5100	14	0.73
chr11_69902083_69902235	0.45	Neurl4	neuralized E3 ubiquitin protein ligase 4	3	0.9
chr12_98628262_98628451	0.45	Spata7	spermatogenesis associated 7	159	0.93
chr7_130710473_130710636	0.45	Tacc2	transforming, acidic coiled-coil containing protein 2	3123	0.24
chr2_69226745_69226961	0.45	G6pc2	glucose-6-phosphatase, catalytic, 2	6825	0.15
chr3_22168181_22168357	0.44	Tbl1xr1	transducin (beta)-like 1X-linked receptor 1	19327	0.21
chr11_75678792_75678954	0.44	Crk	v-crk avian sarcoma virus CT10 oncogene homolog	386	0.8
chr17_27556354_27556505	0.44	Hmga1	high mobility group AT-hook 1	68	0.51
chr14_69171500_69171815	0.43	Nkx2-6	NK2 homeobox 6	145	0.57
chr2_72475881_72476264	0.43	Cdca7	cell division cycle associated 7	87	0.98
chr12_55487707_55488022	0.43	Nfkbia	nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha	3946	0.21
chr12_87300349_87300500	0.42	Ism2	isthmin 2	719	0.52
chr11_120555335_120555502	0.42	Ppp1r27	protein phosphatase 1, regulatory subunit 27	4286	0.07
chr5_132467140_132467305	0.42	Auts2	autism susceptibility candidate 2	17862	0.12
chr3_149546578_149546753	0.42	Gm30382	predicted gene, 30382	101364	0.08
chr5_145852474_145852695	0.42	Cyp3a11	cytochrome P450, family 3, subfamily a, polypeptide 11	24107	0.13
chr9_124281840_124282030	0.41	Gm39469	predicted gene, 39469	204	0.93
chr8_105347302_105347515	0.41	Fhod1	formin homology 2 domain containing 1	501	0.52
chr2_132263417_132263641	0.41	Cds2	CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2	288	0.88
chrX_74305335_74305495	0.40	Gdi1	guanosine diphosphate (GDP) dissociation inhibitor 1	102	0.89
chr12_26469202_26469522	0.40	Cmpk2	cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial	158	0.94
chr15_75974567_75974718	0.40	Zfp707	zinc finger protein 707	1859	0.15
chr8_61574352_61574983	0.40	Palld	palladin, cytoskeletal associated protein	16472	0.25
chr2_118490490_118490877	0.40	Gm13983	predicted gene 13983	6506	0.16
chr4_41713984_41714147	0.40	Rpp25l	ribonuclease P/MRP 25 subunit-like	531	0.59
chr2_4651833_4652008	0.40	Prpf18	pre-mRNA processing factor 18	161	0.96
chr5_76184387_76184581	0.40	Tmem165	transmembrane protein 165	534	0.73
chr13_33003844_33004060	0.40	Serpinb9	serine (or cysteine) peptidase inhibitor, clade B, member 9	589	0.64
chr2_154855271_154855679	0.39	Eif2s2	eukaryotic translation initiation factor 2, subunit 2 (beta)	37307	0.13
chr3_58593720_58593871	0.39	Selenot	selenoprotein T	17097	0.14
chr8_48492721_48492872	0.39	Tenm3	teneurin transmembrane protein 3	62517	0.14
chr5_112282209_112282362	0.38	Tpst2	protein-tyrosine sulfotransferase 2	5578	0.13
chr16_91238840_91239051	0.38	Olig2	oligodendrocyte transcription factor 2	13488	0.11
chr9_108792795_108793094	0.38	Gm23034	predicted gene, 23034	2444	0.14
chr19_41846454_41846665	0.37	Frat2	frequently rearranged in advanced T cell lymphomas 2	1573	0.3
chrX_140568088_140568285	0.37	AL683809.1	TSC22 domain family, member 3 (Tsc22d3), pseuodgene	15413	0.17
chr4_12140361_12140643	0.37	Rbm12b1	RNA binding motif protein 12 B1	185	0.91
chr6_86820856_86821008	0.37	Anxa4	annexin A4	27348	0.1
chr11_83853555_83853722	0.37	Hnf1b	HNF1 homeobox B	678	0.62
chr7_43444450_43444615	0.36	Etfb	electron transferring flavoprotein, beta polypeptide	382	0.4
chr8_70131574_70131799	0.36	Nr2c2ap	nuclear receptor 2C2-associated protein	339	0.73
chr8_109869084_109869235	0.36	Phlpp2	PH domain and leucine rich repeat protein phosphatase 2	548	0.48
chr5_125323526_125323720	0.36	Gm42633	predicted gene 42633	2179	0.22
chr8_121307859_121308016	0.36	Gm26815	predicted gene, 26815	48899	0.13
chr15_99034485_99034683	0.36	Tuba1c	tubulin, alpha 1C	4263	0.11
chr10_44527174_44527473	0.36	Prdm1	PR domain containing 1, with ZNF domain	1178	0.46
chr10_53928699_53928881	0.36	Man1a	mannosidase 1, alpha	48325	0.16
chr3_94399233_94399394	0.35	Lingo4	leucine rich repeat and Ig domain containing 4	796	0.33
chr18_50137858_50138009	0.35	Cd63-ps	CD63 antigen, pseudogene	3138	0.23
chr14_34618565_34618885	0.35	Opn4	opsin 4 (melanopsin)	18583	0.11
chr14_61354089_61354266	0.35	Ebpl	emopamil binding protein-like	6143	0.13
chr11_20733626_20734042	0.35	Gm12036	predicted gene 12036	4414	0.21
chr12_30200282_30200708	0.34	Sntg2	syntrophin, gamma 2	840	0.72
chr5_35030633_35030784	0.34	Gm43791	predicted gene 43791	2737	0.18
chr10_7211859_7212010	0.34	Cnksr3	Cnksr family member 3	303	0.94
chr4_48046634_48046887	0.33	Nr4a3	nuclear receptor subfamily 4, group A, member 3	1529	0.46
chr4_134879692_134879843	0.33	Rhd	Rh blood group, D antigen	43	0.97
chr12_113221349_113221516	0.33	Gm25622	predicted gene, 25622	7283	0.14
chr4_100129098_100129249	0.33	Gm12701	predicted gene 12701	9552	0.23
chr10_122986042_122986255	0.32	D630033A02Rik	RIKEN cDNA D630033A02 gene	317	0.58
chr4_12089474_12090115	0.32	Tmem67	transmembrane protein 67	226	0.62
chr4_135270319_135270473	0.32	Clic4	chloride intracellular channel 4 (mitochondrial)	2418	0.22
chr10_127513114_127513548	0.32	Ndufa4l2	Ndufa4, mitochondrial complex associated like 2	1636	0.21
chr17_30199906_30200207	0.32	Zfand3	zinc finger, AN1-type domain 3	2480	0.27
chr8_33930013_33930185	0.32	Rbpms	RNA binding protein gene with multiple splicing	236	0.92
chr10_25621751_25621928	0.32	Gm36908	predicted gene, 36908	276	0.91
chr19_41847242_41847459	0.32	Frat2	frequently rearranged in advanced T cell lymphomas 2	782	0.55
chr11_120086018_120086485	0.32	Cep131	centrosomal protein 131	576	0.57
chr11_109718016_109718204	0.32	Fam20a	family with sequence similarity 20, member A	4146	0.22
chr4_32240053_32240204	0.32	Bach2	BTB and CNC homology, basic leucine zipper transcription factor 2	1051	0.54
chr12_84939224_84939386	0.32	Arel1	apoptosis resistant E3 ubiquitin protein ligase 1	4073	0.15
chr3_96457950_96458248	0.31	Gm10685	predicted gene 10685	110	0.87
chr3_138422238_138422402	0.31	Adh4	alcohol dehydrogenase 4 (class II), pi polypeptide	6825	0.14
chr1_184785241_184785692	0.31	Mtarc1	mitochondrial amidoxime reducing component 1	23387	0.12
chr15_46598446_46598597	0.31	4930548G14Rik	RIKEN cDNA 4930548G14 gene	24784	0.25
chr13_59004016_59004334	0.31	Gm34245	predicted gene, 34245	74121	0.08
chr4_59311382_59311545	0.31	Susd1	sushi domain containing 1	4503	0.24
chr16_91362482_91362649	0.31	Ifnar2	interferon (alpha and beta) receptor 2	10218	0.11
chr4_132535706_132535867	0.31	Dnajc8	DnaJ heat shock protein family (Hsp40) member C8	127	0.91
chr3_96452393_96452678	0.31	BC107364	cDNA sequence BC107364	229	0.76
chr11_120466994_120467145	0.31	Arl16	ADP-ribosylation factor-like 16	205	0.71
chr10_81135573_81135724	0.31	Zbtb7a	zinc finger and BTB domain containing 7a	428	0.63
chr2_60383071_60383222	0.31	Ly75	lymphocyte antigen 75	85	0.97
chr13_60665524_60665709	0.30	Gm48583	predicted gene, 48583	23826	0.15
chr5_142782966_142783117	0.30	Tnrc18	trinucleotide repeat containing 18	5482	0.21
chr4_128981174_128981543	0.30	Ak2	adenylate kinase 2	10600	0.15
chr17_25507894_25508055	0.30	Gm33727	predicted gene, 33727	10611	0.09
chr8_93227828_93228167	0.30	Ces1e	carboxylesterase 1E	1621	0.29
chr8_85007833_85007986	0.30	Best2	bestrophin 2	5682	0.06
chr4_76343359_76343684	0.30	Ptprd	protein tyrosine phosphatase, receptor type, D	722	0.77
chr5_43781403_43781714	0.30	Fbxl5	F-box and leucine-rich repeat protein 5	542	0.46
chr14_63248471_63248829	0.30	Gata4	GATA binding protein 4	3379	0.22
chrX_13845208_13845423	0.30	Cask	calcium/calmodulin-dependent serine protein kinase (MAGUK family)	773	0.75
chr11_20561304_20561596	0.30	Gm12035	predicted gene 12035	13739	0.2
chr10_30200517_30200678	0.30	Cenpw	centromere protein W	37	0.98
chr19_10239849_10240587	0.29	Myrf	myelin regulatory factor	386	0.77
chr6_17694870_17695095	0.29	St7	suppression of tumorigenicity 7	815	0.54
chr7_31053117_31053317	0.29	Fxyd1	FXYD domain-containing ion transport regulator 1	95	0.91
chr17_56104393_56104561	0.29	Hdgfl2	HDGF like 2	4915	0.09
chr19_23105417_23105568	0.29	2410080I02Rik	RIKEN cDNA 2410080I02 gene	29408	0.13
chr5_102068968_102069164	0.29	Wdfy3	WD repeat and FYVE domain containing 3	855	0.46
chr17_83897414_83897589	0.29	1810073O08Rik	RIKEN cDNA 1810073O08 gene	20436	0.13
chr5_100673907_100674085	0.28	Coq2	coenzyme Q2 4-hydroxybenzoate polyprenyltransferase	160	0.94
chr16_59594968_59595140	0.28	Crybg3	beta-gamma crystallin domain containing 3	5925	0.21
chr12_59235308_59235463	0.28	Gm27284	predicted gene, 27284	1791	0.28
chr3_107631354_107631565	0.28	Gm10961	predicted gene 10961	137	0.63
chr2_103472788_103473367	0.28	Cat	catalase	12048	0.18
chr2_26922374_26922531	0.28	Surf2	surfeit gene 2	5024	0.08
chr15_76606976_76607461	0.28	Cpsf1	cleavage and polyadenylation specific factor 1	271	0.77
chr1_131971555_131972013	0.28	Slc45a3	solute carrier family 45, member 3	1175	0.35
chr6_113494556_113494760	0.28	Creld1	cysteine-rich with EGF-like domains 1	2639	0.11
chr7_132852781_132852967	0.28	Eef1akmt2	EEF1A lysine methyltransferase 2	201	0.91
chr10_89770056_89770207	0.28	Uhrf1bp1l	UHRF1 (ICBP90) binding protein 1-like	17069	0.18
chr9_61914762_61915200	0.28	Rplp1	ribosomal protein, large, P1	439	0.83
chr8_27054619_27054804	0.27	Plpbp	pyridoxal phosphate binding protein	3937	0.13
chr1_139422425_139422762	0.27	Zbtb41	zinc finger and BTB domain containing 41	211	0.92
chr7_110942462_110942613	0.27	Mrvi1	MRV integration site 1	3650	0.23
chr14_20995157_20995320	0.27	Vcl	vinculin	26765	0.17
chr10_80702834_80702996	0.27	Izumo4	IZUMO family member 4	144	0.87
chr11_116187883_116188093	0.27	Acox1	acyl-Coenzyme A oxidase 1, palmitoyl	1587	0.21
chr4_145774583_145774829	0.27	Gm13243	predicted gene 13243	13	0.94
chr1_74723320_74723471	0.27	Cyp27a1	cytochrome P450, family 27, subfamily a, polypeptide 1	9821	0.12
chr9_63550824_63550989	0.27	Gm16759	predicted gene, 16759	19554	0.18
chr7_29155799_29155976	0.27	Fam98c	family with sequence similarity 98, member C	168	0.52
chr7_19095153_19095353	0.27	Six5	sine oculis-related homeobox 5	659	0.44
chr1_74016328_74016481	0.27	Tns1	tensin 1	18	0.98
chr2_103595080_103595270	0.27	Abtb2	ankyrin repeat and BTB (POZ) domain containing 2	28865	0.16
chr17_44256731_44256898	0.27	Clic5	chloride intracellular channel 5	19708	0.26
chr2_153632897_153633072	0.27	Commd7	COMM domain containing 7	203	0.93
chr1_93128050_93128201	0.26	Gm28086	predicted gene 28086	4022	0.15
chr9_96718101_96718252	0.26	Zbtb38	zinc finger and BTB domain containing 38	1389	0.38
chr2_92376664_92376833	0.26	Pex16	peroxisomal biogenesis factor 16	1189	0.28
chr6_66896024_66896206	0.26	Gng12	guanine nucleotide binding protein (G protein), gamma 12	282	0.6
chr6_141327961_141328118	0.26	Gm10400	predicted gene 10400	12514	0.24
chr7_132811347_132811663	0.25	Fam53b	family with sequence similarity 53, member B	1590	0.34
chr16_24629324_24629735	0.25	Lpp	LIM domain containing preferred translocation partner in lipoma	92326	0.08
chr17_24349257_24349433	0.25	Abca17	ATP-binding cassette, sub-family A (ABC1), member 17	1684	0.2
chr10_28387713_28387881	0.25	Ptprk	protein tyrosine phosphatase, receptor type, K	172354	0.03
chr1_90238643_90238822	0.25	Gm38277	predicted gene, 38277	10206	0.16
chr3_8961467_8961864	0.25	Tpd52	tumor protein D52	588	0.76
chr16_15888920_15889238	0.25	Cebpd	CCAAT/enhancer binding protein (C/EBP), delta	663	0.71
chr5_125389673_125389844	0.25	Ubc	ubiquitin C	256	0.64
chr9_62355457_62355637	0.25	Anp32a	acidic (leucine-rich) nuclear phosphoprotein 32 family, member A	10748	0.2
chr11_60727211_60727861	0.24	Flii	flightless I actin binding protein	273	0.67
chr10_93432561_93432735	0.24	Mir7688	microRNA 7688	459	0.78
chr5_38260278_38260440	0.24	Tmem128	transmembrane protein 128	12	0.97

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of Runx3

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.4	GO:0046075	dTTP biosynthetic process(GO:0006235) pyrimidine deoxyribonucleoside triphosphate biosynthetic process(GO:0009212) dTTP metabolic process(GO:0046075)
0.1	0.4	GO:0009093	cysteine catabolic process(GO:0009093) L-cysteine catabolic process(GO:0019448) L-cysteine metabolic process(GO:0046439)
0.1	0.4	GO:0000350	generation of catalytic spliceosome for second transesterification step(GO:0000350)
0.1	0.4	GO:0046341	CDP-diacylglycerol metabolic process(GO:0046341)
0.1	0.3	GO:1902564	negative regulation of neutrophil activation(GO:1902564)
0.1	0.3	GO:0032286	central nervous system myelin maintenance(GO:0032286)
0.1	0.4	GO:1903546	protein localization to photoreceptor outer segment(GO:1903546)
0.1	0.3	GO:0010255	carbohydrate mediated signaling(GO:0009756) hexose mediated signaling(GO:0009757) sugar mediated signaling pathway(GO:0010182) glucose mediated signaling pathway(GO:0010255)
0.1	0.4	GO:0090315	negative regulation of protein targeting to membrane(GO:0090315)
0.1	0.3	GO:0072488	ammonium transmembrane transport(GO:0072488)
0.1	0.2	GO:1902071	regulation of hypoxia-inducible factor-1alpha signaling pathway(GO:1902071)
0.1	0.2	GO:0072095	regulation of branch elongation involved in ureteric bud branching(GO:0072095)
0.1	0.2	GO:0006114	glycerol biosynthetic process(GO:0006114)
0.1	0.3	GO:0001922	B-1 B cell homeostasis(GO:0001922)
0.1	0.2	GO:0033668	negative regulation by symbiont of host apoptotic process(GO:0033668) negative regulation by symbiont of host programmed cell death(GO:0052041) negative regulation by organism of programmed cell death in other organism involved in symbiotic interaction(GO:0052490)
0.1	0.3	GO:0071638	negative regulation of monocyte chemotactic protein-1 production(GO:0071638)
0.1	0.2	GO:0009223	pyrimidine deoxyribonucleotide catabolic process(GO:0009223)
0.1	0.2	GO:1900625	regulation of monocyte aggregation(GO:1900623) positive regulation of monocyte aggregation(GO:1900625)
0.1	0.2	GO:1903797	positive regulation of inorganic anion transmembrane transport(GO:1903797)
0.0	0.1	GO:0009838	abscission(GO:0009838)
0.0	0.1	GO:0061153	trachea submucosa development(GO:0061152) trachea gland development(GO:0061153)
0.0	0.4	GO:0034058	endosomal vesicle fusion(GO:0034058)
0.0	0.1	GO:0035964	COPI-coated vesicle budding(GO:0035964)
0.0	0.1	GO:0015772	disaccharide transport(GO:0015766) sucrose transport(GO:0015770) oligosaccharide transport(GO:0015772)
0.0	0.3	GO:0097105	presynaptic membrane assembly(GO:0097105)
0.0	0.1	GO:0036112	medium-chain fatty-acyl-CoA metabolic process(GO:0036112)
0.0	0.3	GO:0090557	establishment of endothelial intestinal barrier(GO:0090557)
0.0	0.5	GO:0060211	regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060211) positive regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060213)
0.0	0.2	GO:0010792	DNA double-strand break processing involved in repair via single-strand annealing(GO:0010792)
0.0	0.1	GO:0006933	negative regulation of cell adhesion involved in substrate-bound cell migration(GO:0006933)
0.0	0.1	GO:0070384	Harderian gland development(GO:0070384)
0.0	0.1	GO:0032513	negative regulation of protein phosphatase type 2B activity(GO:0032513)
0.0	0.1	GO:1901252	regulation of intracellular transport of viral material(GO:1901252)
0.0	0.1	GO:0006067	ethanol metabolic process(GO:0006067) ethanol oxidation(GO:0006069)
0.0	0.1	GO:1900377	negative regulation of melanin biosynthetic process(GO:0048022) negative regulation of secondary metabolite biosynthetic process(GO:1900377)
0.0	0.1	GO:0035461	vitamin transmembrane transport(GO:0035461)
0.0	0.2	GO:0071267	amino acid salvage(GO:0043102) L-methionine biosynthetic process(GO:0071265) L-methionine salvage(GO:0071267)
0.0	0.1	GO:0036091	positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress(GO:0036091)
0.0	0.1	GO:0021699	cerebellar cortex maturation(GO:0021699)
0.0	0.1	GO:0072205	metanephric collecting duct development(GO:0072205)
0.0	0.1	GO:1900242	regulation of synaptic vesicle endocytosis(GO:1900242)
0.0	0.4	GO:0060391	positive regulation of SMAD protein import into nucleus(GO:0060391)
0.0	0.4	GO:0035020	regulation of Rac protein signal transduction(GO:0035020)
0.0	0.3	GO:0035751	regulation of lysosomal lumen pH(GO:0035751)
0.0	0.2	GO:0006646	phosphatidylethanolamine biosynthetic process(GO:0006646)
0.0	0.1	GO:0090210	regulation of establishment of blood-brain barrier(GO:0090210)
0.0	0.1	GO:2000721	positive regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation(GO:2000721)
0.0	0.3	GO:0051382	kinetochore assembly(GO:0051382)
0.0	0.2	GO:0002051	osteoblast fate commitment(GO:0002051)
0.0	0.1	GO:1903223	positive regulation of oxidative stress-induced neuron death(GO:1903223)
0.0	0.2	GO:0035735	intraciliary transport involved in cilium morphogenesis(GO:0035735)
0.0	0.1	GO:0006269	DNA replication, synthesis of RNA primer(GO:0006269)
0.0	0.2	GO:0030643	cellular phosphate ion homeostasis(GO:0030643) cellular trivalent inorganic anion homeostasis(GO:0072502)
0.0	0.2	GO:0045630	positive regulation of T-helper 2 cell differentiation(GO:0045630)
0.0	0.2	GO:0010992	ubiquitin homeostasis(GO:0010992)
0.0	0.2	GO:0000729	DNA double-strand break processing(GO:0000729)
0.0	0.1	GO:0006172	ADP biosynthetic process(GO:0006172)
0.0	0.2	GO:0031665	negative regulation of lipopolysaccharide-mediated signaling pathway(GO:0031665)
0.0	0.1	GO:2000255	negative regulation of male germ cell proliferation(GO:2000255)
0.0	0.1	GO:0072675	osteoclast fusion(GO:0072675)
0.0	0.1	GO:1900122	positive regulation of receptor binding(GO:1900122)
0.0	0.3	GO:0006744	ubiquinone biosynthetic process(GO:0006744)
0.0	0.2	GO:0009650	UV protection(GO:0009650)
0.0	0.1	GO:0010499	proteasomal ubiquitin-independent protein catabolic process(GO:0010499)
0.0	0.2	GO:0006273	lagging strand elongation(GO:0006273)
0.0	0.1	GO:0010046	response to mycotoxin(GO:0010046)
0.0	0.2	GO:0043951	negative regulation of cAMP-mediated signaling(GO:0043951)
0.0	0.1	GO:0046271	phenylpropanoid catabolic process(GO:0046271)
0.0	0.1	GO:1904139	microglial cell migration(GO:1904124) regulation of microglial cell migration(GO:1904139)
0.0	0.1	GO:0001692	histamine metabolic process(GO:0001692)
0.0	0.2	GO:0032075	positive regulation of nuclease activity(GO:0032075)
0.0	0.3	GO:0050872	white fat cell differentiation(GO:0050872)
0.0	0.1	GO:0036135	Schwann cell migration(GO:0036135) regulation of Schwann cell migration(GO:1900147)
0.0	0.1	GO:0007084	mitotic nuclear envelope reassembly(GO:0007084)
0.0	0.1	GO:2000189	positive regulation of cholesterol homeostasis(GO:2000189)
0.0	0.1	GO:0035973	aggrephagy(GO:0035973)
0.0	0.1	GO:0002071	glandular epithelial cell maturation(GO:0002071)
0.0	0.1	GO:0023021	termination of signal transduction(GO:0023021)
0.0	0.1	GO:0048133	germ-line stem cell division(GO:0042078) male germ-line stem cell asymmetric division(GO:0048133) germline stem cell asymmetric division(GO:0098728)
0.0	0.1	GO:0038171	cannabinoid signaling pathway(GO:0038171) endocannabinoid signaling pathway(GO:0071926)
0.0	0.1	GO:0048539	bone marrow development(GO:0048539)
0.0	0.1	GO:0070427	nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070427)
0.0	0.1	GO:0010990	regulation of SMAD protein complex assembly(GO:0010990) negative regulation of SMAD protein complex assembly(GO:0010991)
0.0	0.3	GO:0010839	negative regulation of keratinocyte proliferation(GO:0010839)
0.0	0.1	GO:0036302	atrioventricular canal development(GO:0036302)
0.0	0.1	GO:0021564	vagus nerve development(GO:0021564)
0.0	0.1	GO:0072531	pyrimidine-containing compound transmembrane transport(GO:0072531)
0.0	0.1	GO:2000474	regulation of opioid receptor signaling pathway(GO:2000474)
0.0	0.1	GO:0006772	thiamine metabolic process(GO:0006772) thiamine-containing compound metabolic process(GO:0042723)
0.0	0.1	GO:0044539	long-chain fatty acid import(GO:0044539)
0.0	0.2	GO:0014842	regulation of skeletal muscle satellite cell proliferation(GO:0014842)
0.0	0.0	GO:0050427	3'-phosphoadenosine 5'-phosphosulfate metabolic process(GO:0050427)
0.0	0.0	GO:0002378	immunoglobulin biosynthetic process(GO:0002378)
0.0	0.1	GO:0090527	actin filament reorganization(GO:0090527)
0.0	0.1	GO:0036215	response to stem cell factor(GO:0036215) cellular response to stem cell factor stimulus(GO:0036216) Kit signaling pathway(GO:0038109)
0.0	0.1	GO:0001712	ectodermal cell fate commitment(GO:0001712)
0.0	0.2	GO:0030388	fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.0	0.1	GO:0060842	arterial endothelial cell differentiation(GO:0060842)
0.0	0.1	GO:0006283	transcription-coupled nucleotide-excision repair(GO:0006283)
0.0	0.1	GO:1990000	amyloid fibril formation(GO:1990000)
0.0	0.1	GO:0097503	sialylation(GO:0097503)
0.0	0.3	GO:0097237	cellular response to toxic substance(GO:0097237)
0.0	0.1	GO:0071712	ER-associated misfolded protein catabolic process(GO:0071712)
0.0	0.1	GO:0019626	short-chain fatty acid catabolic process(GO:0019626)
0.0	0.0	GO:0021524	visceral motor neuron differentiation(GO:0021524)
0.0	0.1	GO:0055118	negative regulation of cardiac muscle contraction(GO:0055118)
0.0	0.1	GO:0032464	positive regulation of protein homooligomerization(GO:0032464)
0.0	0.1	GO:0015722	canalicular bile acid transport(GO:0015722)
0.0	0.1	GO:0035519	protein K29-linked ubiquitination(GO:0035519)
0.0	0.2	GO:0003334	keratinocyte development(GO:0003334)
0.0	0.0	GO:0009202	deoxyribonucleoside triphosphate biosynthetic process(GO:0009202)
0.0	0.0	GO:0009826	unidimensional cell growth(GO:0009826)
0.0	0.0	GO:0043553	negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553)
0.0	0.1	GO:0019530	taurine metabolic process(GO:0019530)
0.0	0.2	GO:0070129	regulation of mitochondrial translation(GO:0070129)
0.0	0.0	GO:0030242	pexophagy(GO:0030242)
0.0	0.0	GO:0007195	adenylate cyclase-inhibiting dopamine receptor signaling pathway(GO:0007195)
0.0	0.0	GO:0090360	platelet-derived growth factor production(GO:0090360) regulation of platelet-derived growth factor production(GO:0090361)
0.0	0.0	GO:0045218	zonula adherens maintenance(GO:0045218)
0.0	0.0	GO:0007525	somatic muscle development(GO:0007525)
0.0	0.1	GO:0019934	cGMP-mediated signaling(GO:0019934)
0.0	0.0	GO:0042732	D-xylose metabolic process(GO:0042732)
0.0	0.2	GO:0032211	negative regulation of telomere maintenance via telomerase(GO:0032211)
0.0	0.1	GO:0071243	cellular response to arsenic-containing substance(GO:0071243)
0.0	0.0	GO:0032058	positive regulation of translational initiation in response to stress(GO:0032058)
0.0	0.1	GO:0046929	negative regulation of neurotransmitter secretion(GO:0046929)
0.0	0.0	GO:0006678	glucosylceramide metabolic process(GO:0006678)
0.0	0.3	GO:0006379	mRNA cleavage(GO:0006379)
0.0	0.0	GO:0046909	intermembrane transport(GO:0046909)
0.0	0.1	GO:2000052	positive regulation of non-canonical Wnt signaling pathway(GO:2000052)
0.0	0.1	GO:0010606	positive regulation of cytoplasmic mRNA processing body assembly(GO:0010606)
0.0	0.1	GO:0060056	mammary gland involution(GO:0060056)
0.0	0.1	GO:0015879	carnitine transport(GO:0015879)
0.0	0.2	GO:2000651	positive regulation of sodium ion transmembrane transporter activity(GO:2000651)
0.0	0.0	GO:0038108	negative regulation of appetite by leptin-mediated signaling pathway(GO:0038108)
0.0	0.1	GO:0000463	maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000463)
0.0	0.0	GO:0035359	negative regulation of peroxisome proliferator activated receptor signaling pathway(GO:0035359)
0.0	0.1	GO:0051014	actin filament severing(GO:0051014)
0.0	0.1	GO:0043562	cellular response to nitrogen starvation(GO:0006995) cellular response to nitrogen levels(GO:0043562)
0.0	0.0	GO:2000346	negative regulation of hepatocyte proliferation(GO:2000346)
0.0	0.1	GO:0034227	tRNA thio-modification(GO:0034227)
0.0	0.1	GO:0046033	AMP metabolic process(GO:0046033)
0.0	0.0	GO:0016095	polyprenol catabolic process(GO:0016095)
0.0	0.0	GO:0031627	telomeric loop formation(GO:0031627)
0.0	0.1	GO:0060573	ventral spinal cord interneuron specification(GO:0021521) cell fate specification involved in pattern specification(GO:0060573)
0.0	0.8	GO:0019369	arachidonic acid metabolic process(GO:0019369)
0.0	0.1	GO:0006020	inositol metabolic process(GO:0006020)
0.0	0.1	GO:0031937	positive regulation of chromatin silencing(GO:0031937)
0.0	0.0	GO:2000143	negative regulation of transcription initiation from RNA polymerase II promoter(GO:0060633) negative regulation of DNA-templated transcription, initiation(GO:2000143)
0.0	0.2	GO:0000413	protein peptidyl-prolyl isomerization(GO:0000413)
0.0	0.1	GO:0036120	cellular response to platelet-derived growth factor stimulus(GO:0036120)
0.0	0.1	GO:1902018	negative regulation of cilium assembly(GO:1902018)
0.0	0.0	GO:0061197	fungiform papilla morphogenesis(GO:0061197) fungiform papilla formation(GO:0061198)
0.0	0.1	GO:0023035	CD40 signaling pathway(GO:0023035)
0.0	0.0	GO:2000483	negative regulation of interleukin-8 secretion(GO:2000483)
0.0	0.4	GO:0006284	base-excision repair(GO:0006284)
0.0	0.0	GO:1904263	positive regulation of TORC1 signaling(GO:1904263)
0.0	0.0	GO:0034165	positive regulation of toll-like receptor 9 signaling pathway(GO:0034165)
0.0	0.0	GO:2000286	receptor internalization involved in canonical Wnt signaling pathway(GO:2000286)
0.0	0.0	GO:1904220	regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity(GO:1904217) positive regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity(GO:1904219) regulation of serine C-palmitoyltransferase activity(GO:1904220) positive regulation of serine C-palmitoyltransferase activity(GO:1904222)
0.0	0.1	GO:0000395	mRNA 5'-splice site recognition(GO:0000395)
0.0	0.0	GO:0042447	hormone catabolic process(GO:0042447)
0.0	0.1	GO:0006614	SRP-dependent cotranslational protein targeting to membrane(GO:0006614)
0.0	0.2	GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146)
0.0	0.0	GO:1901552	positive regulation of endothelial cell development(GO:1901552) positive regulation of establishment of endothelial barrier(GO:1903142)
0.0	0.3	GO:0015909	long-chain fatty acid transport(GO:0015909)
0.0	0.0	GO:1900748	positive regulation of vascular endothelial growth factor signaling pathway(GO:1900748)
0.0	0.1	GO:0075525	viral translational termination-reinitiation(GO:0075525)
0.0	0.0	GO:0021529	spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530)
0.0	0.0	GO:0072197	ureter morphogenesis(GO:0072197) metanephric nephron tubule formation(GO:0072289)
0.0	0.1	GO:0043517	positive regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043517)
0.0	0.1	GO:0007184	SMAD protein import into nucleus(GO:0007184)
0.0	0.0	GO:1902036	regulation of hematopoietic stem cell differentiation(GO:1902036)
0.0	0.0	GO:0070836	caveola assembly(GO:0070836)
0.0	0.0	GO:0019676	ammonia assimilation cycle(GO:0019676)
0.0	0.0	GO:0070358	actin polymerization-dependent cell motility(GO:0070358)
0.0	0.1	GO:0006104	succinyl-CoA metabolic process(GO:0006104)
0.0	0.1	GO:0044598	polyketide metabolic process(GO:0030638) aminoglycoside antibiotic metabolic process(GO:0030647) daunorubicin metabolic process(GO:0044597) doxorubicin metabolic process(GO:0044598)
0.0	0.0	GO:0070889	platelet alpha granule organization(GO:0070889)
0.0	0.0	GO:2000587	regulation of platelet-derived growth factor receptor-beta signaling pathway(GO:2000586) negative regulation of platelet-derived growth factor receptor-beta signaling pathway(GO:2000587)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.2	GO:0005658	alpha DNA polymerase:primase complex(GO:0005658)
0.1	0.4	GO:0033263	CORVET complex(GO:0033263)
0.1	0.2	GO:0045251	mitochondrial electron transfer flavoprotein complex(GO:0017133) electron transfer flavoprotein complex(GO:0045251)
0.0	0.1	GO:0005945	6-phosphofructokinase complex(GO:0005945)
0.0	0.1	GO:0035985	senescence-associated heterochromatin focus(GO:0035985)
0.0	0.2	GO:0001739	sex chromatin(GO:0001739)
0.0	0.2	GO:0000120	RNA polymerase I transcription factor complex(GO:0000120)
0.0	0.1	GO:0036449	microtubule minus-end(GO:0036449)
0.0	0.1	GO:0097648	G-protein coupled receptor dimeric complex(GO:0038037) G-protein coupled receptor complex(GO:0097648)
0.0	0.1	GO:0097418	neurofibrillary tangle(GO:0097418)
0.0	0.1	GO:0032127	dense core granule membrane(GO:0032127)
0.0	0.1	GO:0070552	BRISC complex(GO:0070552)
0.0	0.2	GO:0002139	stereocilia coupling link(GO:0002139)
0.0	0.1	GO:1990761	growth cone lamellipodium(GO:1990761)
0.0	0.2	GO:0031371	ubiquitin conjugating enzyme complex(GO:0031371)
0.0	0.1	GO:0043625	delta DNA polymerase complex(GO:0043625)
0.0	0.1	GO:0034274	Atg12-Atg5-Atg16 complex(GO:0034274)
0.0	0.1	GO:0030127	COPII vesicle coat(GO:0030127)
0.0	0.1	GO:0097136	Bcl-2 family protein complex(GO:0097136)
0.0	0.4	GO:0005682	U5 snRNP(GO:0005682)
0.0	0.2	GO:0042622	photoreceptor outer segment membrane(GO:0042622)
0.0	0.1	GO:0005786	signal recognition particle, endoplasmic reticulum targeting(GO:0005786) signal recognition particle(GO:0048500)
0.0	0.1	GO:0097342	ripoptosome(GO:0097342)
0.0	0.3	GO:0031235	intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.0	0.1	GO:0033093	Weibel-Palade body(GO:0033093)
0.0	0.1	GO:0090543	Flemming body(GO:0090543)
0.0	0.1	GO:0072669	tRNA-splicing ligase complex(GO:0072669)
0.0	0.2	GO:0033116	endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116)
0.0	0.1	GO:0030485	smooth muscle contractile fiber(GO:0030485)
0.0	0.2	GO:0005847	mRNA cleavage and polyadenylation specificity factor complex(GO:0005847)
0.0	0.1	GO:0030121	AP-1 adaptor complex(GO:0030121)
0.0	0.1	GO:0042406	extrinsic component of endoplasmic reticulum membrane(GO:0042406)
0.0	0.2	GO:0070852	cell body fiber(GO:0070852)
0.0	0.1	GO:0000127	transcription factor TFIIIC complex(GO:0000127)
0.0	0.1	GO:0061574	ASAP complex(GO:0061574)
0.0	0.1	GO:0017101	aminoacyl-tRNA synthetase multienzyme complex(GO:0017101)
0.0	0.2	GO:0000783	telomere cap complex(GO:0000782) nuclear telomere cap complex(GO:0000783)
0.0	0.2	GO:0005652	nuclear lamina(GO:0005652)
0.0	0.1	GO:0031502	dolichyl-phosphate-mannose-protein mannosyltransferase complex(GO:0031502)
0.0	0.1	GO:0044326	dendritic spine neck(GO:0044326)
0.0	0.3	GO:0032588	trans-Golgi network membrane(GO:0032588)
0.0	0.1	GO:0000439	core TFIIH complex(GO:0000439)
0.0	0.1	GO:0089701	U2AF(GO:0089701)
0.0	0.2	GO:0035327	transcriptionally active chromatin(GO:0035327)
0.0	0.0	GO:0031523	Myb complex(GO:0031523)
0.0	0.3	GO:0030687	preribosome, large subunit precursor(GO:0030687)
0.0	0.0	GO:0000938	GARP complex(GO:0000938)
0.0	0.4	GO:0032391	photoreceptor connecting cilium(GO:0032391)
0.0	0.6	GO:0019005	SCF ubiquitin ligase complex(GO:0019005)
0.0	0.0	GO:0010009	cytoplasmic side of endosome membrane(GO:0010009)
0.0	0.0	GO:0002193	MAML1-RBP-Jkappa- ICN1 complex(GO:0002193)
0.0	0.0	GO:0032021	NELF complex(GO:0032021)
0.0	0.0	GO:0031262	Ndc80 complex(GO:0031262)
0.0	0.1	GO:0005664	origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
0.0	0.1	GO:0016281	eukaryotic translation initiation factor 4F complex(GO:0016281)
0.0	0.1	GO:0031258	lamellipodium membrane(GO:0031258)
0.0	0.2	GO:0043034	costamere(GO:0043034)
0.0	0.1	GO:0008024	cyclin/CDK positive transcription elongation factor complex(GO:0008024)
0.0	0.1	GO:1904115	axon cytoplasm(GO:1904115)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.4	GO:0009041	uridylate kinase activity(GO:0009041)
0.1	0.4	GO:0004605	phosphatidate cytidylyltransferase activity(GO:0004605)
0.1	0.4	GO:0000386	second spliceosomal transesterification activity(GO:0000386)
0.1	0.2	GO:0097109	neuroligin family protein binding(GO:0097109)
0.1	0.2	GO:0008898	S-adenosylmethionine-homocysteine S-methyltransferase activity(GO:0008898)
0.1	0.2	GO:0046573	lactonohydrolase activity(GO:0046573) acyl-L-homoserine-lactone lactonohydrolase activity(GO:0102007)
0.1	0.2	GO:0051575	5'-deoxyribose-5-phosphate lyase activity(GO:0051575)
0.1	0.1	GO:0032564	dATP binding(GO:0032564)
0.1	0.2	GO:0030144	alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity(GO:0030144)
0.0	0.1	GO:0004416	hydroxyacylglutathione hydrolase activity(GO:0004416)
0.0	0.1	GO:0015157	sucrose:proton symporter activity(GO:0008506) sucrose transmembrane transporter activity(GO:0008515) disaccharide transmembrane transporter activity(GO:0015154) oligosaccharide transmembrane transporter activity(GO:0015157)
0.0	0.1	GO:0003872	6-phosphofructokinase activity(GO:0003872)
0.0	0.2	GO:0004305	ethanolamine kinase activity(GO:0004305)
0.0	0.1	GO:0004096	catalase activity(GO:0004096)
0.0	0.4	GO:0019103	pyrimidine nucleotide binding(GO:0019103)
0.0	0.1	GO:0008309	double-stranded DNA exodeoxyribonuclease activity(GO:0008309)
0.0	0.1	GO:0004024	alcohol dehydrogenase activity, zinc-dependent(GO:0004024)
0.0	0.0	GO:0004022	alcohol dehydrogenase (NAD) activity(GO:0004022)
0.0	0.5	GO:0005092	GDP-dissociation inhibitor activity(GO:0005092)
0.0	0.1	GO:0000702	oxidized base lesion DNA N-glycosylase activity(GO:0000702)
0.0	0.1	GO:0030942	endoplasmic reticulum signal peptide binding(GO:0030942)
0.0	0.1	GO:0004965	G-protein coupled GABA receptor activity(GO:0004965)
0.0	0.1	GO:0016508	long-chain-enoyl-CoA hydratase activity(GO:0016508)
0.0	0.1	GO:0070878	primary miRNA binding(GO:0070878)
0.0	0.1	GO:0005173	stem cell factor receptor binding(GO:0005173)
0.0	0.1	GO:0034186	apolipoprotein A-I binding(GO:0034186)
0.0	0.3	GO:0015245	fatty acid transporter activity(GO:0015245)
0.0	0.2	GO:0097027	ubiquitin-protein transferase activator activity(GO:0097027)
0.0	0.1	GO:0005157	macrophage colony-stimulating factor receptor binding(GO:0005157)
0.0	0.2	GO:0050786	RAGE receptor binding(GO:0050786)
0.0	0.8	GO:0070330	aromatase activity(GO:0070330)
0.0	0.0	GO:0004771	sterol esterase activity(GO:0004771)
0.0	0.2	GO:0035925	mRNA 3'-UTR AU-rich region binding(GO:0035925)
0.0	0.1	GO:1990254	keratin filament binding(GO:1990254)
0.0	0.1	GO:0004030	aldehyde dehydrogenase [NAD(P)+] activity(GO:0004030)
0.0	0.1	GO:0051434	BH3 domain binding(GO:0051434)
0.0	0.1	GO:0050309	glucose-6-phosphatase activity(GO:0004346) sugar-terminal-phosphatase activity(GO:0050309)
0.0	0.1	GO:0016623	aldehyde oxidase activity(GO:0004031) oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor(GO:0016623)
0.0	0.2	GO:0070180	large ribosomal subunit rRNA binding(GO:0070180)
0.0	0.2	GO:0051371	muscle alpha-actinin binding(GO:0051371)
0.0	0.2	GO:0003708	retinoic acid receptor activity(GO:0003708)
0.0	0.5	GO:0005070	SH3/SH2 adaptor activity(GO:0005070)
0.0	0.1	GO:0004300	enoyl-CoA hydratase activity(GO:0004300)
0.0	0.3	GO:0008143	poly(A) binding(GO:0008143)
0.0	0.2	GO:0034944	pinocarveol dehydrogenase activity(GO:0018446) chloral hydrate dehydrogenase activity(GO:0018447) hydroxymethylmethylsilanediol oxidase activity(GO:0018448) 1-phenylethanol dehydrogenase activity(GO:0018449) myrtenol dehydrogenase activity(GO:0018450) cis-1,2-dihydroxy-1,2-dihydro-8-carboxynaphthalene dehydrogenase activity(GO:0034522) 3-hydroxy-4-methyloctanoyl-CoA dehydrogenase activity(GO:0034582) 2-hydroxy-4-isopropenylcyclohexane-1-carboxyl-CoA dehydrogenase activity(GO:0034778) cis-9,10-dihydroanthracene-9,10-diol dehydrogenase activity(GO:0034817) citronellol dehydrogenase activity(GO:0034821) naphthyl-2-hydroxymethyl-succinyl-CoA dehydrogenase activity(GO:0034847) 2,4,4-trimethyl-1-pentanol dehydrogenase activity(GO:0034863) 2,4,4-trimethyl-3-hydroxypentanoyl-CoA dehydrogenase activity(GO:0034868) 1-hydroxy-4,4-dimethylpentan-3-one dehydrogenase activity(GO:0034871) endosulfan diol dehydrogenase activity(GO:0034891) endosulfan hydroxyether dehydrogenase activity(GO:0034901) 3-hydroxy-2-methylhexanoyl-CoA dehydrogenase activity(GO:0034918) 3-hydroxy-2,6-dimethyl-5-methylene-heptanoyl-CoA dehydrogenase activity(GO:0034944) versicolorin reductase activity(GO:0042469) ketoreductase activity(GO:0045703)
0.0	0.2	GO:0016717	oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water(GO:0016717)
0.0	0.1	GO:0097200	cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:0097200)
0.0	0.2	GO:0010521	telomerase inhibitor activity(GO:0010521)
0.0	0.2	GO:0042043	neurexin family protein binding(GO:0042043)
0.0	0.1	GO:0035851	Krueppel-associated box domain binding(GO:0035851)
0.0	0.1	GO:0016401	palmitoyl-CoA oxidase activity(GO:0016401)
0.0	0.2	GO:0001206	transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206)
0.0	0.1	GO:0072345	NAADP-sensitive calcium-release channel activity(GO:0072345)
0.0	0.2	GO:0005123	death receptor binding(GO:0005123)
0.0	0.1	GO:0003941	L-serine ammonia-lyase activity(GO:0003941)
0.0	0.1	GO:0030280	structural constituent of epidermis(GO:0030280)
0.0	0.1	GO:0005432	calcium:sodium antiporter activity(GO:0005432)
0.0	0.5	GO:0051059	NF-kappaB binding(GO:0051059)
0.0	0.1	GO:0002094	polyprenyltransferase activity(GO:0002094)
0.0	0.2	GO:0042301	phosphate ion binding(GO:0042301)
0.0	0.1	GO:0043426	MRF binding(GO:0043426)
0.0	0.0	GO:0031433	telethonin binding(GO:0031433)
0.0	0.0	GO:0004741	[pyruvate dehydrogenase (lipoamide)] phosphatase activity(GO:0004741)
0.0	0.1	GO:0032050	clathrin heavy chain binding(GO:0032050)
0.0	0.1	GO:0051011	microtubule minus-end binding(GO:0051011)
0.0	0.0	GO:0042284	sphingolipid delta-4 desaturase activity(GO:0042284)
0.0	0.0	GO:0004468	lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468)
0.0	0.2	GO:0051787	misfolded protein binding(GO:0051787)
0.0	0.1	GO:0004017	adenylate kinase activity(GO:0004017)
0.0	0.5	GO:0031624	ubiquitin conjugating enzyme binding(GO:0031624)
0.0	0.2	GO:0034450	ubiquitin-ubiquitin ligase activity(GO:0034450)
0.0	0.1	GO:0008140	cAMP response element binding protein binding(GO:0008140)
0.0	0.2	GO:0016290	palmitoyl-CoA hydrolase activity(GO:0016290)
0.0	0.1	GO:0030957	Tat protein binding(GO:0030957)
0.0	0.4	GO:0035035	histone acetyltransferase binding(GO:0035035)
0.0	0.3	GO:0008519	ammonium transmembrane transporter activity(GO:0008519)
0.0	0.1	GO:0001135	transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
0.0	0.2	GO:0070530	K63-linked polyubiquitin binding(GO:0070530)
0.0	0.1	GO:0004791	thioredoxin-disulfide reductase activity(GO:0004791)
0.0	0.1	GO:0035497	cAMP response element binding(GO:0035497)
0.0	0.0	GO:0046976	histone methyltransferase activity (H3-K27 specific)(GO:0046976)
0.0	0.1	GO:0008440	inositol-1,4,5-trisphosphate 3-kinase activity(GO:0008440)
0.0	0.1	GO:0001163	RNA polymerase I regulatory region sequence-specific DNA binding(GO:0001163) RNA polymerase I CORE element sequence-specific DNA binding(GO:0001164)
0.0	0.1	GO:0003831	beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity(GO:0003831)
0.0	0.2	GO:0001618	virus receptor activity(GO:0001618)
0.0	0.1	GO:0051735	cobinamide kinase activity(GO:0008819) phytol kinase activity(GO:0010276) phenol kinase activity(GO:0018720) cyclin-dependent protein kinase activating kinase regulator activity(GO:0019914) inositol tetrakisphosphate 2-kinase activity(GO:0032942) heptose 7-phosphate kinase activity(GO:0033785) aminoglycoside phosphotransferase activity(GO:0034071) eukaryotic elongation factor-2 kinase regulator activity(GO:0042556) eukaryotic elongation factor-2 kinase activator activity(GO:0042557) LPPG:FO 2-phospho-L-lactate transferase activity(GO:0043743) cytidine kinase activity(GO:0043771) glycerate 2-kinase activity(GO:0043798) (S)-lactate 2-kinase activity(GO:0043841) phosphoserine:homoserine phosphotransferase activity(GO:0043899) L-seryl-tRNA(Sec) kinase activity(GO:0043915) phosphocholine transferase activity(GO:0044605) GTP-dependent polynucleotide kinase activity(GO:0051735) farnesol kinase activity(GO:0052668) CTP:2-trans,-6-trans-farnesol kinase activity(GO:0052669) geraniol kinase activity(GO:0052670) geranylgeraniol kinase activity(GO:0052671) CTP:geranylgeraniol kinase activity(GO:0052672) prenol kinase activity(GO:0052673) 1-phosphatidylinositol-5-kinase activity(GO:0052810) 1-phosphatidylinositol-3-phosphate 4-kinase activity(GO:0052811) phosphatidylinositol-3,4-bisphosphate 5-kinase activity(GO:0052812) inositol-3,4,6-trisphosphate 1-kinase activity(GO:0052835) inositol 5-diphosphate pentakisphosphate 5-kinase activity(GO:0052836) inositol diphosphate tetrakisphosphate kinase activity(GO:0052839)
0.0	0.0	GO:0005502	11-cis retinal binding(GO:0005502)
0.0	0.1	GO:0004779	sulfate adenylyltransferase activity(GO:0004779)
0.0	0.1	GO:1990841	promoter-specific chromatin binding(GO:1990841)
0.0	0.1	GO:0070097	delta-catenin binding(GO:0070097)
0.0	0.1	GO:0003688	DNA replication origin binding(GO:0003688)
0.0	0.1	GO:0004301	epoxide hydrolase activity(GO:0004301)
0.0	0.1	GO:0050321	tau-protein kinase activity(GO:0050321)
0.0	0.2	GO:0004198	calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.0	0.0	GO:0033592	RNA strand annealing activity(GO:0033592)
0.0	0.1	GO:0070300	phosphatidic acid binding(GO:0070300)
0.0	0.1	GO:0008494	translation activator activity(GO:0008494)
0.0	0.0	GO:0004345	glucose-6-phosphate dehydrogenase activity(GO:0004345)
0.0	0.0	GO:0038181	bile acid receptor activity(GO:0038181)
0.0	0.1	GO:0004303	estradiol 17-beta-dehydrogenase activity(GO:0004303)
0.0	0.0	GO:0043125	ErbB-3 class receptor binding(GO:0043125)
0.0	0.0	GO:1990460	leptin receptor binding(GO:1990460)
0.0	0.1	GO:0050649	testosterone 6-beta-hydroxylase activity(GO:0050649)
0.0	0.0	GO:0004332	fructose-bisphosphate aldolase activity(GO:0004332)
0.0	0.0	GO:0004656	procollagen-proline 4-dioxygenase activity(GO:0004656)

Gene overrepresentation in curated gene sets: canonical pathways category:

Total log-likelihood	Term	Description
0.3	PID TCR JNK PATHWAY	JNK signaling in the CD4+ TCR pathway
0.4	PID WNT NONCANONICAL PATHWAY	Noncanonical Wnt signaling pathway
0.3	PID AR NONGENOMIC PATHWAY	Nongenotropic Androgen signaling
0.4	SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES	Genes related to regulation of the actin cytoskeleton
0.1	PID BETA CATENIN DEG PATHWAY	Degradation of beta catenin
0.3	PID SYNDECAN 2 PATHWAY	Syndecan-2-mediated signaling events
0.2	PID AVB3 OPN PATHWAY	Osteopontin-mediated events
0.2	ST GA12 PATHWAY	G alpha 12 Pathway
0.0	PID THROMBIN PAR1 PATHWAY	PAR1-mediated thrombin signaling events
0.1	SA B CELL RECEPTOR COMPLEXES	Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.2	REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION	Genes involved in APOBEC3G mediated resistance to HIV-1 infection
0.0	0.5	REACTOME P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS	Genes involved in p130Cas linkage to MAPK signaling for integrins
0.0	0.1	REACTOME REGULATION OF KIT SIGNALING	Genes involved in Regulation of KIT signaling
0.0	0.2	REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION	Genes involved in Apoptosis induced DNA fragmentation
0.0	0.3	REACTOME POL SWITCHING	Genes involved in Polymerase switching
0.0	0.2	REACTOME SYNTHESIS OF PE	Genes involved in Synthesis of PE
0.0	0.2	REACTOME PURINE CATABOLISM	Genes involved in Purine catabolism
0.0	0.2	REACTOME IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION	Genes involved in IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
0.0	0.3	REACTOME CTNNB1 PHOSPHORYLATION CASCADE	Genes involved in Beta-catenin phosphorylation cascade
0.0	0.1	REACTOME NFKB IS ACTIVATED AND SIGNALS SURVIVAL	Genes involved in NF-kB is activated and signals survival
0.0	0.4	REACTOME SULFUR AMINO ACID METABOLISM	Genes involved in Sulfur amino acid metabolism
0.0	0.4	REACTOME REGULATORY RNA PATHWAYS	Genes involved in Regulatory RNA pathways
0.0	0.2	REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS	Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.0	0.1	REACTOME IRAK1 RECRUITS IKK COMPLEX	Genes involved in IRAK1 recruits IKK complex
0.0	0.1	REACTOME RECYCLING OF BILE ACIDS AND SALTS	Genes involved in Recycling of bile acids and salts
0.0	0.1	REACTOME TRANSPORT OF ORGANIC ANIONS	Genes involved in Transport of organic anions
0.0	0.2	REACTOME PROCESSING OF INTRONLESS PRE MRNAS	Genes involved in Processing of Intronless Pre-mRNAs
0.0	0.3	REACTOME RNA POL I TRANSCRIPTION TERMINATION	Genes involved in RNA Polymerase I Transcription Termination
0.0	0.1	REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24 HYDROXYCHOLESTEROL	Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol
0.0	0.2	REACTOME N GLYCAN ANTENNAE ELONGATION	Genes involved in N-Glycan antennae elongation
0.0	0.1	REACTOME DOWNSTREAM SIGNAL TRANSDUCTION	Genes involved in Downstream signal transduction
0.0	0.0	REACTOME OLFACTORY SIGNALING PATHWAY	Genes involved in Olfactory Signaling Pathway
0.0	0.1	REACTOME ETHANOL OXIDATION	Genes involved in Ethanol oxidation
0.0	0.2	REACTOME FGFR1 LIGAND BINDING AND ACTIVATION	Genes involved in FGFR1 ligand binding and activation
0.0	0.1	REACTOME SPRY REGULATION OF FGF SIGNALING	Genes involved in Spry regulation of FGF signaling
0.0	0.2	REACTOME MRNA 3 END PROCESSING	Genes involved in mRNA 3'-end processing
0.0	0.1	REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS	Genes involved in Apoptotic cleavage of cell adhesion proteins
0.0	0.1	REACTOME THE NLRP3 INFLAMMASOME	Genes involved in The NLRP3 inflammasome
0.0	0.1	REACTOME BASE FREE SUGAR PHOSPHATE REMOVAL VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY	Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway
0.0	0.2	REACTOME SIGNALING BY BMP	Genes involved in Signaling by BMP
0.0	0.2	REACTOME RNA POL III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER	Genes involved in RNA Polymerase III Transcription Initiation From Type 2 Promoter
0.0	0.1	REACTOME IKK COMPLEX RECRUITMENT MEDIATED BY RIP1	Genes involved in IKK complex recruitment mediated by RIP1