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ENCSR904DTN: DNase-seq of mouse liver in constant darkness

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Results for Six3_Six1_Six2

Z-value: 1.41

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Transcription factors associated with Six3_Six1_Six2

Gene Symbol	Gene ID	Gene Info
Six3 Ensembl NCBI MGI UniProt	ENSMUSG00000038805.9	sine oculis-related homeobox 3
Six1 Ensembl NCBI MGI UniProt	ENSMUSG00000051367.8	sine oculis-related homeobox 1
Six2 Ensembl NCBI MGI UniProt	ENSMUSG00000024134.10	sine oculis-related homeobox 2

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
chr12_73021062_73021221	Six1	21674	0.168534	-0.78	6.8e-02	Click!
chr12_73061092_73061267	Six1	7292	0.202324	-0.68	1.4e-01	Click!
chr12_73044137_73044486	Six1	980	0.577302	-0.55	2.6e-01	Click!
chr12_73014527_73014702	Six1	28201	0.150745	0.46	3.6e-01	Click!
chr12_73053301_73053539	Six1	467	0.826734	-0.46	3.6e-01	Click!
chr17_85665071_85665231	Six2	23103	0.136943	-0.64	1.7e-01	Click!
chr17_85664762_85664917	Six2	23415	0.136153	0.13	8.0e-01	Click!
chr17_85633742_85633899	Six3	12789	0.138615	-0.81	5.0e-02	Click!

Activity of the Six3_Six1_Six2 motif across conditions

Conditions sorted by the z-value of the Six3_Six1_Six2 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr8_121351760_121351911	2.43	Gm26815	predicted gene, 26815	5001	0.24
chr4_155566693_155567032	2.10	Nadk	NAD kinase	2790	0.15
chr13_64229004_64229155	1.88	Cdc14b	CDC14 cell division cycle 14B	16797	0.1
chr15_81521072_81521223	1.72	Gm5218	predicted gene 5218	21602	0.11
chr10_94835120_94835271	1.58	Plxnc1	plexin C1	5649	0.18
chr8_64716760_64716977	1.21	Msmo1	methylsterol monoxygenase 1	5063	0.17
chr2_68873804_68874167	1.15	Cers6	ceramide synthase 6	12399	0.14
chr6_145807948_145808259	1.08	Rassf8	Ras association (RalGDS/AF-6) domain family (N-terminal) member 8	280	0.92
chr7_123123444_123123981	1.08	Tnrc6a	trinucleotide repeat containing 6a	173	0.96
chr5_90872752_90873224	1.06	Cxcl1	chemokine (C-X-C motif) ligand 1	18253	0.11
chr10_5593553_5593753	1.06	Myct1	myc target 1	122	0.97
chr1_132362082_132362267	1.03	Tmcc2	transmembrane and coiled-coil domains 2	2774	0.18
chr1_72293871_72294177	1.01	Tmem169	transmembrane protein 169	9629	0.13
chr16_85541732_85541897	1.00	Cyyr1	cysteine and tyrosine-rich protein 1	8603	0.23
chr14_26534922_26535085	1.00	Slmap	sarcolemma associated protein	72	0.96
chr3_67553994_67554162	0.98	Gm35299	predicted gene, 35299	653	0.6
chr12_113147543_113147726	0.98	Crip1	cysteine-rich protein 1 (intestinal)	1071	0.33
chr5_145978084_145978621	0.95	Gm43115	predicted gene 43115	9942	0.13
chr12_25092894_25093391	0.94	Id2	inhibitor of DNA binding 2	2945	0.22
chr4_140598032_140598205	0.94	Arhgef10l	Rho guanine nucleotide exchange factor (GEF) 10-like	6078	0.22
chr17_12415417_12415751	0.94	Plg	plasminogen	36925	0.12
chr18_53254459_53254751	0.91	Snx24	sorting nexing 24	8836	0.23
chr7_19955922_19956099	0.89	Rpl7a-ps8	ribosomal protein L7A, pseudogene 8	2227	0.14
chr9_22339507_22339658	0.88	Gm6607	predicted gene 6607	9082	0.09
chr4_3682969_3683158	0.88	Lyn	LYN proto-oncogene, Src family tyrosine kinase	4933	0.18
chr15_38661347_38661720	0.87	Atp6v1c1	ATPase, H+ transporting, lysosomal V1 subunit C1	400	0.79
chr8_68025403_68025869	0.87	Gm22018	predicted gene, 22018	15296	0.22
chr18_67765309_67765869	0.86	Gm26910	predicted gene, 26910	9268	0.15
chr4_6449285_6449445	0.85	Nsmaf	neutral sphingomyelinase (N-SMase) activation associated factor	3038	0.27
chr1_89428817_89429012	0.84	C030007H22Rik	RIKEN cDNA C030007H22 gene	22781	0.17
chr17_66352364_66352831	0.84	Mtcl1	microtubule crosslinking factor 1	6052	0.19
chr16_31419378_31420071	0.83	Bdh1	3-hydroxybutyrate dehydrogenase, type 1	2556	0.19
chr6_127152476_127152648	0.83	Ccnd2	cyclin D2	369	0.76
chr12_73544837_73545005	0.82	Tmem30b	transmembrane protein 30B	1471	0.35
chr11_48978357_48978522	0.79	Olfr56	olfactory receptor 56	450	0.57
chr11_101952845_101953096	0.79	4930417O22Rik	RIKEN cDNA 4930417O22 gene	549	0.6
chr10_37484779_37484938	0.77	Gm48172	predicted gene, 48172	32178	0.24
chr2_69415616_69415767	0.77	Dhrs9	dehydrogenase/reductase (SDR family) member 9	35246	0.16
chr5_121612131_121612311	0.76	Acad12	acyl-Coenzyme A dehydrogenase family, member 12	6592	0.11
chr17_46031864_46032231	0.76	Vegfa	vascular endothelial growth factor A	232	0.92
chr2_37672780_37672960	0.75	Gm13543	predicted gene 13543	662	0.65
chr7_98077544_98077739	0.75	Myo7a	myosin VIIA	7078	0.22
chr8_123097696_123097880	0.74	Spg7	SPG7, paraplegin matrix AAA peptidase subunit	3267	0.11
chr4_115610472_115610686	0.73	Cyp4a32	cytochrome P450, family 4, subfamily a, polypeptide 32	9604	0.13
chr10_20165798_20165969	0.73	Map7	microtubule-associated protein 7	4897	0.19
chrX_93159224_93159387	0.72	1700003E24Rik	RIKEN cDNA 1700003E24 gene	3151	0.24
chr11_49050203_49050359	0.72	Olfr56	olfactory receptor 56	452	0.56
chr11_16874000_16874630	0.72	Egfr	epidermal growth factor receptor	3835	0.25
chr8_115089778_115090403	0.70	Gm22556	predicted gene, 22556	37177	0.23
chr10_93522322_93522473	0.68	Amdhd1	amidohydrolase domain containing 1	17636	0.12
chr4_137642271_137642473	0.67	Usp48	ubiquitin specific peptidase 48	1969	0.3
chr1_87217869_87218207	0.67	Eif4e2	eukaryotic translation initiation factor 4E member 2	3752	0.13
chr9_66511571_66511763	0.67	Fbxl22	F-box and leucine-rich repeat protein 22	2942	0.22
chr18_64480427_64480605	0.67	Fech	ferrochelatase	1005	0.49
chr18_46714530_46714763	0.66	Cdo1	cysteine dioxygenase 1, cytosolic	13383	0.13
chr6_19992020_19992306	0.66	Gm42581	predicted gene 42581	204110	0.03
chr2_38287855_38288027	0.66	Dennd1a	DENN/MADD domain containing 1A	551	0.71
chr11_74833681_74834010	0.66	Mnt	max binding protein	2481	0.19
chr6_73253072_73253734	0.66	Suclg1	succinate-CoA ligase, GDP-forming, alpha subunit	4735	0.2
chr6_23125960_23126120	0.65	Aass	aminoadipate-semialdehyde synthase	1540	0.34
chr14_25687077_25687249	0.65	Ppif	peptidylprolyl isomerase F (cyclophilin F)	6991	0.14
chr12_8003138_8004354	0.65	Apob	apolipoprotein B	8613	0.24
chr10_118064905_118065056	0.64	5330439M10Rik	RIKEN cDNA 5330439M10 gene	47537	0.11
chr6_128597268_128597481	0.64	Gm44009	predicted gene, 44009	9349	0.09
chr10_87832168_87832548	0.64	Igf1os	insulin-like growth factor 1, opposite strand	3996	0.26
chr13_56648096_56648259	0.63	Tgfbi	transforming growth factor, beta induced	16964	0.19
chr15_83471603_83471756	0.63	Pacsin2	protein kinase C and casein kinase substrate in neurons 2	7073	0.15
chr18_16757253_16757556	0.63	Gm15485	predicted gene 15485	28671	0.19
chr13_38350227_38350425	0.63	Bmp6	bone morphogenetic protein 6	4173	0.2
chr1_61649997_61650160	0.62	Gm37205	predicted gene, 37205	4345	0.17
chr9_103037075_103037388	0.62	Gm22595	predicted gene, 22595	14765	0.14
chr2_10156330_10156481	0.62	Itih5	inter-alpha (globulin) inhibitor H5	2834	0.18
chr13_51639138_51639293	0.61	Cks2	CDC28 protein kinase regulatory subunit 2	6017	0.18
chr12_109521275_109521426	0.61	Gm34081	predicted gene, 34081	4610	0.06
chr13_112753469_112753867	0.61	Gm47850	predicted gene, 47850	11180	0.15
chr7_44749310_44749461	0.61	Vrk3	vaccinia related kinase 3	442	0.55
chr4_105261100_105261481	0.61	Plpp3	phospholipid phosphatase 3	103943	0.07
chr13_64398164_64398509	0.61	Ctsl	cathepsin L	27446	0.09
chr8_36631797_36631968	0.60	Dlc1	deleted in liver cancer 1	17939	0.26
chr18_69543963_69544114	0.60	Gm24845	predicted gene, 24845	7925	0.25
chr10_19910647_19910806	0.60	Pex7	peroxisomal biogenesis factor 7	3037	0.25
chr11_48900988_48901186	0.59	Gm5431	predicted gene 5431	1065	0.36
chr10_68256241_68256415	0.59	Arid5b	AT rich interactive domain 5B (MRF1-like)	22393	0.21
chr17_74206593_74206763	0.59	Gm9316	predicted gene 9316	5280	0.16
chr4_12143157_12143374	0.59	Rbm12b1	RNA binding motif protein 12 B1	2948	0.17
chr13_42528321_42528472	0.59	Gm47125	predicted gene, 47125	41067	0.17
chr13_32897014_32897418	0.59	Serpinb1c	serine (or cysteine) peptidase inhibitor, clade B, member 1c	941	0.49
chr10_7298433_7298657	0.58	Cnksr3	Cnksr family member 3	86308	0.08
chr16_76506417_76506570	0.58	Gm45030	predicted gene 45030	3584	0.29
chr12_111944676_111945000	0.58	5033406O09Rik	RIKEN cDNA 5033406O09 gene	354	0.78
chr19_4498576_4498743	0.58	2010003K11Rik	RIKEN cDNA 2010003K11 gene	76	0.96
chr1_161006639_161006973	0.57	Gm37072	predicted gene, 37072	4961	0.06
chr8_72220521_72220759	0.57	Fam32a	family with sequence similarity 32, member A	876	0.39
chr18_47329689_47330033	0.57	Sema6a	sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A	3465	0.29
chr10_46108907_46109077	0.57	Gm35430	predicted gene, 35430	119647	0.06
chr2_35100620_35100804	0.57	AI182371	expressed sequence AI182371	23	0.97
chr10_125114451_125114602	0.56	Gm36719	predicted gene, 36719	118543	0.06
chr1_4597988_4598139	0.56	Gm37323	predicted gene, 37323	11811	0.14
chr4_144910401_144910587	0.56	Dhrs3	dehydrogenase/reductase (SDR family) member 3	8385	0.21
chr5_134321784_134321935	0.56	Mir3965	microRNA 3965	4595	0.15
chr11_53811145_53811296	0.56	Gm12216	predicted gene 12216	15345	0.12
chr10_54040650_54041019	0.56	Gm47917	predicted gene, 47917	22977	0.18
chr10_91124308_91124694	0.56	Slc25a3	solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 3	442	0.77
chr12_112109668_112109994	0.56	Mir3073b	microRNA 3073b	522	0.45
chr16_38457286_38457437	0.56	Cd80	CD80 antigen	1572	0.26
chr19_29180240_29180403	0.56	Gm5518	predicted gene 5518	20203	0.15
chr1_71941001_71941178	0.55	Gm28818	predicted gene 28818	23964	0.16
chr6_142470707_142470939	0.55	Gys2	glycogen synthase 2	2286	0.28
chr8_93333023_93333204	0.55	Ces1g	carboxylesterase 1G	4195	0.17
chr7_19466718_19466904	0.55	Gm45167	predicted gene 45167	1417	0.2
chr17_28886003_28886154	0.55	1700030A11Rik	RIKEN cDNA 1700030A11 gene	19187	0.08
chr5_141852294_141852464	0.55	Sdk1	sidekick cell adhesion molecule 1	4408	0.36
chr4_101369995_101370146	0.55	0610043K17Rik	RIKEN cDNA 0610043K17 gene	3419	0.14
chr1_37057171_37057502	0.54	Vwa3b	von Willebrand factor A domain containing 3B	21628	0.17
chr3_127895575_127896072	0.54	Fam241a	family with sequence similarity 241, member A	465	0.74
chr8_36692573_36692758	0.53	Dlc1	deleted in liver cancer 1	40389	0.2
chr5_103977096_103977309	0.53	Hsd17b13	hydroxysteroid (17-beta) dehydrogenase 13	124	0.95
chr2_181193098_181193249	0.53	Ppdpf	pancreatic progenitor cell differentiation and proliferation factor	5259	0.1
chr16_36556726_36556894	0.53	Casr	calcium-sensing receptor	4796	0.13
chr6_121992123_121992633	0.52	Mug2	murinoglobulin 2	14383	0.19
chr8_84831664_84831823	0.52	Gadd45gip1	growth arrest and DNA-damage-inducible, gamma interacting protein 1	221	0.74
chr1_132075974_132076135	0.52	Mfsd4a	major facilitator superfamily domain containing 4A	7992	0.13
chr2_153597348_153597499	0.52	Commd7	COMM domain containing 7	35308	0.13
chr5_96536140_96536523	0.52	Gm42605	predicted gene 42605	50565	0.14
chr5_88645260_88645648	0.51	Rufy3	RUN and FYVE domain containing 3	1237	0.44
chr15_10799724_10800004	0.51	Gm19276	predicted gene, 19276	14928	0.22
chr7_80971090_80971368	0.51	Gm18782	predicted gene, 18782	8664	0.11
chr4_60658520_60658671	0.51	Mup11	major urinary protein 11	1143	0.46
chr9_123529517_123529735	0.51	Sacm1l	SAC1 suppressor of actin mutations 1-like (yeast)	133	0.96
chr11_20381578_20381759	0.51	Gm12033	predicted gene 12033	45655	0.12
chr6_91686029_91686235	0.51	Slc6a6	solute carrier family 6 (neurotransmitter transporter, taurine), member 6	1983	0.22
chr19_4462072_4462253	0.51	Syt12	synaptotagmin XII	10011	0.12
chr7_112323864_112324015	0.50	Mical2	microtubule associated monooxygenase, calponin and LIM domain containing 2	7910	0.29
chr11_63878725_63878897	0.50	Hmgb1-ps3	high mobility group box 1, pseudogene 3	31993	0.17
chr6_52725417_52725568	0.50	Gm43967	predicted gene, 43967	2562	0.22
chr11_53758327_53758553	0.50	Mir7671	microRNA 7671	5214	0.11
chr13_119723468_119723673	0.50	Nim1k	NIM1 serine/threonine protein kinase	14824	0.11
chr3_95635523_95635875	0.49	E330034L11Rik	RIKEN cDNA E330034L11 gene	3605	0.12
chr7_43451775_43451928	0.49	Etfb	electron transferring flavoprotein, beta polypeptide	1039	0.24
chr14_93884578_93884756	0.49	Pcdh9	protocadherin 9	1081	0.65
chr2_18898037_18898206	0.49	Pip4k2a	phosphatidylinositol-5-phosphate 4-kinase, type II, alpha	8153	0.25
chr15_98732323_98732512	0.49	Fkbp11	FK506 binding protein 11	4219	0.11
chr5_114122907_114123086	0.49	Alkbh2	alkB homolog 2, alpha-ketoglutarate-dependent dioxygenase	5180	0.11
chr1_41561549_41561708	0.49	Gm28634	predicted gene 28634	32085	0.25
chr19_4061177_4061378	0.49	Gstp3	glutathione S-transferase pi 3	1708	0.14
chr1_71586837_71587028	0.49	Fn1	fibronectin 1	4139	0.24
chr14_31641448_31641615	0.49	Hacl1	2-hydroxyacyl-CoA lyase 1	245	0.62
chr5_145986709_145986916	0.49	Cyp3a25	cytochrome P450, family 3, subfamily a, polypeptide 25	4831	0.14
chr10_99384294_99384806	0.48	B530045E10Rik	RIKEN cDNA B530045E10 gene	18240	0.17
chr4_97911823_97911983	0.48	Nfia	nuclear factor I/A	870	0.73
chrX_135202950_135203109	0.48	Tceal6	transcription elongation factor A (SII)-like 6	7658	0.13
chr11_48823440_48823657	0.48	Trim7	tripartite motif-containing 7	2592	0.13
chr16_13206124_13206388	0.48	Mrtfb	myocardin related transcription factor B	50225	0.15
chr4_133012806_133012983	0.48	Ahdc1	AT hook, DNA binding motif, containing 1	690	0.68
chr5_87139047_87139701	0.47	Ugt2b5	UDP glucuronosyltransferase 2 family, polypeptide B5	944	0.44
chr9_110702981_110703204	0.47	Ccdc12	coiled-coil domain containing 12	6802	0.12
chrX_85801951_85802103	0.47	Gm6964	predicted gene 6964	7907	0.13
chr9_44802615_44802885	0.47	Ttc36	tetratricopeptide repeat domain 36	322	0.74
chr16_22899990_22900163	0.47	Ahsg	alpha-2-HS-glycoprotein	5212	0.13
chr1_150404692_150404850	0.47	Tpr	translocated promoter region, nuclear basket protein	7226	0.17
chr3_60053807_60054248	0.46	Aadac	arylacetamide deacetylase	22151	0.14
chr5_105700503_105701198	0.46	Lrrc8d	leucine rich repeat containing 8D	16	0.98
chr18_7645003_7645196	0.46	Mpp7	membrane protein, palmitoylated 7 (MAGUK p55 subfamily member 7)	18233	0.2
chr13_73775744_73776073	0.46	Slc12a7	solute carrier family 12, member 7	12169	0.17
chr5_96913731_96913882	0.46	Gm43147	predicted gene 43147	565	0.58
chr14_56511307_56511470	0.46	Rnf17	ring finger protein 17	2105	0.28
chr10_18527860_18528028	0.46	Hebp2	heme binding protein 2	17943	0.2
chr6_28293136_28293302	0.45	Zfp800	zinc finger protein 800	31287	0.14
chr7_145041280_145041599	0.45	Ccnd1	cyclin D1	101514	0.06
chr10_80434280_80434454	0.45	Tcf3	transcription factor 3	720	0.46
chr12_118289062_118289236	0.45	Sp4	trans-acting transcription factor 4	12219	0.25
chr15_30286316_30286475	0.45	Ctnnd2	catenin (cadherin associated protein), delta 2	113257	0.06
chr1_164220195_164220547	0.45	Slc19a2	solute carrier family 19 (thiamine transporter), member 2	28675	0.12
chr17_43329954_43330122	0.45	Adgrf5	adhesion G protein-coupled receptor F5	30413	0.2
chr6_71206132_71206290	0.45	Fabp1	fatty acid binding protein 1, liver	6384	0.13
chr8_126586607_126587402	0.44	Irf2bp2	interferon regulatory factor 2 binding protein 2	6982	0.23
chr17_84877556_84877740	0.44	Gm49982	predicted gene, 49982	24921	0.14
chr8_117327258_117327561	0.44	Cmip	c-Maf inducing protein	21761	0.23
chr12_80909548_80909699	0.44	Gm23298	predicted gene, 23298	1854	0.26
chr5_21701818_21701974	0.44	Napepld	N-acyl phosphatidylethanolamine phospholipase D	500	0.72
chr9_48819198_48819510	0.44	Zbtb16	zinc finger and BTB domain containing 16	16591	0.23
chr15_81989785_81989958	0.44	Xrcc6	X-ray repair complementing defective repair in Chinese hamster cells 6	2036	0.15
chr13_42792378_42792553	0.44	Gm15810	predicted gene 15810	4207	0.29
chr4_136689035_136689208	0.43	Ephb2	Eph receptor B2	4919	0.19
chr11_33814738_33814898	0.43	Kcnip1	Kv channel-interacting protein 1	28643	0.21
chr1_74376061_74376212	0.43	Slc11a1	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1	521	0.63
chr14_67631586_67631785	0.43	Gm47010	predicted gene, 47010	42893	0.12
chr12_8015700_8015973	0.43	Apob	apolipoprotein B	3477	0.3
chr13_47183455_47183623	0.43	Rnf144b	ring finger protein 144B	10286	0.16
chr7_126689123_126689285	0.42	Gm6939	predicted gene 6939	830	0.32
chr8_126586433_126586584	0.42	Irf2bp2	interferon regulatory factor 2 binding protein 2	7478	0.23
chr5_121696090_121696243	0.42	Brap	BRCA1 associated protein	13238	0.1
chr2_124555012_124555366	0.42	Sema6d	sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D	54917	0.17
chr9_58275190_58275612	0.42	Stoml1	stomatin-like 1	15174	0.13
chr5_32092059_32092277	0.42	Babam2	BRISC and BRCA1 A complex member 2	12471	0.17
chr18_34864196_34864456	0.42	Egr1	early growth response 1	3119	0.18
chr1_58121350_58121753	0.42	Aox3	aldehyde oxidase 3	8365	0.2
chr13_7429202_7429555	0.42	Gm36074	predicted gene, 36074	17131	0.28
chr5_146908786_146908951	0.42	Gtf3a	general transcription factor III A	39789	0.11
chr7_141266376_141266537	0.42	Irf7	interferon regulatory factor 7	25	0.94

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of Six3_Six1_Six2

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	0.6	GO:0038086	VEGF-activated platelet-derived growth factor receptor signaling pathway(GO:0038086) positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway(GO:0038091)
0.2	0.5	GO:0006868	glutamine transport(GO:0006868)
0.2	0.5	GO:0032483	regulation of Rab protein signal transduction(GO:0032483)
0.1	0.4	GO:0045472	response to ether(GO:0045472)
0.1	0.4	GO:0010735	positive regulation of transcription via serum response element binding(GO:0010735)
0.1	0.4	GO:0006741	NADP biosynthetic process(GO:0006741)
0.1	0.4	GO:1903999	negative regulation of eating behavior(GO:1903999)
0.1	0.5	GO:0070447	positive regulation of oligodendrocyte progenitor proliferation(GO:0070447)
0.1	0.5	GO:0001561	fatty acid alpha-oxidation(GO:0001561)
0.1	0.5	GO:0038161	prolactin signaling pathway(GO:0038161)
0.1	0.6	GO:0072378	blood coagulation, fibrin clot formation(GO:0072378)
0.1	0.3	GO:0002309	T cell proliferation involved in immune response(GO:0002309)
0.1	0.2	GO:0038044	transforming growth factor-beta secretion(GO:0038044) regulation of transforming growth factor-beta secretion(GO:2001201)
0.1	0.4	GO:0009115	xanthine catabolic process(GO:0009115)
0.1	1.0	GO:0035278	miRNA mediated inhibition of translation(GO:0035278)
0.1	0.3	GO:0015015	heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.1	0.4	GO:0052805	histidine catabolic process(GO:0006548) imidazole-containing compound catabolic process(GO:0052805)
0.1	0.2	GO:0006553	lysine metabolic process(GO:0006553)
0.1	0.2	GO:0070948	regulation of neutrophil mediated cytotoxicity(GO:0070948) regulation of neutrophil mediated killing of symbiont cell(GO:0070949)
0.1	0.3	GO:1904393	regulation of skeletal muscle acetylcholine-gated channel clustering(GO:1904393) positive regulation of skeletal muscle acetylcholine-gated channel clustering(GO:1904395)
0.1	0.2	GO:0010911	regulation of isomerase activity(GO:0010911) positive regulation of isomerase activity(GO:0010912)
0.1	0.2	GO:0006982	response to lipid hydroperoxide(GO:0006982)
0.1	0.1	GO:0034196	acylglycerol transport(GO:0034196) triglyceride transport(GO:0034197)
0.1	0.5	GO:1903862	positive regulation of oxidative phosphorylation(GO:1903862)
0.1	0.2	GO:0003166	bundle of His development(GO:0003166)
0.1	0.4	GO:0002756	MyD88-independent toll-like receptor signaling pathway(GO:0002756)
0.1	0.3	GO:0046501	protoporphyrinogen IX metabolic process(GO:0046501)
0.1	0.3	GO:0051661	maintenance of centrosome location(GO:0051661)
0.1	0.2	GO:0003347	epicardial cell to mesenchymal cell transition(GO:0003347)
0.1	0.2	GO:2000173	negative regulation of branching morphogenesis of a nerve(GO:2000173)
0.1	0.3	GO:0006703	estrogen biosynthetic process(GO:0006703)
0.1	0.2	GO:1903279	regulation of calcium:sodium antiporter activity(GO:1903279)
0.1	0.2	GO:0032349	positive regulation of aldosterone metabolic process(GO:0032346) positive regulation of aldosterone biosynthetic process(GO:0032349)
0.1	0.4	GO:0010886	positive regulation of cholesterol storage(GO:0010886)
0.1	0.2	GO:0006990	positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response(GO:0006990)
0.1	0.2	GO:0006556	S-adenosylmethionine biosynthetic process(GO:0006556)
0.1	0.2	GO:0097384	ether lipid biosynthetic process(GO:0008611) glycerol ether biosynthetic process(GO:0046504) cellular lipid biosynthetic process(GO:0097384) ether biosynthetic process(GO:1901503)
0.1	0.2	GO:0034093	positive regulation of maintenance of sister chromatid cohesion(GO:0034093) positive regulation of maintenance of mitotic sister chromatid cohesion(GO:0034184)
0.1	0.1	GO:2001187	positive regulation of CD8-positive, alpha-beta T cell activation(GO:2001187)
0.1	0.2	GO:1900747	negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747)
0.1	0.2	GO:0002326	B cell lineage commitment(GO:0002326)
0.0	0.1	GO:2000574	regulation of microtubule motor activity(GO:2000574)
0.0	0.1	GO:0060167	regulation of adenosine receptor signaling pathway(GO:0060167)
0.0	0.2	GO:1902744	negative regulation of lamellipodium organization(GO:1902744)
0.0	0.1	GO:0045658	regulation of neutrophil differentiation(GO:0045658)
0.0	0.1	GO:1904430	negative regulation of t-circle formation(GO:1904430)
0.0	0.3	GO:0030300	regulation of intestinal cholesterol absorption(GO:0030300)
0.0	0.5	GO:1902285	semaphorin-plexin signaling pathway involved in neuron projection guidance(GO:1902285)
0.0	0.1	GO:1902075	cellular response to salt(GO:1902075)
0.0	0.2	GO:2000418	positive regulation of eosinophil migration(GO:2000418)
0.0	0.2	GO:1904668	positive regulation of ubiquitin protein ligase activity(GO:1904668)
0.0	0.3	GO:0071493	cellular response to UV-B(GO:0071493)
0.0	0.1	GO:0014858	positive regulation of skeletal muscle cell proliferation(GO:0014858)
0.0	0.2	GO:0034638	phosphatidylcholine catabolic process(GO:0034638)
0.0	0.2	GO:0070295	renal water absorption(GO:0070295)
0.0	0.1	GO:0019344	cysteine biosynthetic process(GO:0019344)
0.0	0.3	GO:0045759	negative regulation of action potential(GO:0045759)
0.0	0.1	GO:0040031	snRNA modification(GO:0040031)
0.0	0.1	GO:0035790	platelet-derived growth factor receptor-alpha signaling pathway(GO:0035790)
0.0	0.0	GO:0045876	positive regulation of sister chromatid cohesion(GO:0045876)
0.0	0.1	GO:1901529	positive regulation of anion channel activity(GO:1901529)
0.0	0.1	GO:0071879	positive regulation of adrenergic receptor signaling pathway(GO:0071879)
0.0	0.1	GO:0071896	protein localization to adherens junction(GO:0071896)
0.0	0.1	GO:0046121	deoxyribonucleoside catabolic process(GO:0046121)
0.0	0.1	GO:0050747	positive regulation of lipoprotein metabolic process(GO:0050747)
0.0	0.1	GO:0046654	tetrahydrofolate biosynthetic process(GO:0046654)
0.0	0.1	GO:0006768	biotin metabolic process(GO:0006768)
0.0	0.1	GO:0001543	ovarian follicle rupture(GO:0001543)
0.0	0.2	GO:0043031	negative regulation of macrophage activation(GO:0043031)
0.0	0.1	GO:2000275	regulation of oxidative phosphorylation uncoupler activity(GO:2000275)
0.0	0.5	GO:0007202	activation of phospholipase C activity(GO:0007202)
0.0	0.2	GO:0051418	interphase microtubule nucleation by interphase microtubule organizing center(GO:0051415) microtubule nucleation by microtubule organizing center(GO:0051418)
0.0	0.2	GO:1904707	positive regulation of vascular smooth muscle cell proliferation(GO:1904707)
0.0	0.0	GO:1902109	negative regulation of mitochondrial membrane permeability involved in apoptotic process(GO:1902109)
0.0	0.1	GO:1904263	positive regulation of TORC1 signaling(GO:1904263)
0.0	0.2	GO:0086073	bundle of His cell-Purkinje myocyte adhesion involved in cell communication(GO:0086073)
0.0	0.1	GO:0072566	chemokine (C-X-C motif) ligand 1 production(GO:0072566) regulation of chemokine (C-X-C motif) ligand 1 production(GO:2000338)
0.0	0.1	GO:0072223	metanephric glomerular mesangium development(GO:0072223) metanephric glomerular mesangial cell proliferation involved in metanephros development(GO:0072262)
0.0	0.3	GO:0030575	nuclear body organization(GO:0030575)
0.0	0.1	GO:0006172	ADP biosynthetic process(GO:0006172)
0.0	0.2	GO:0006398	mRNA 3'-end processing by stem-loop binding and cleavage(GO:0006398)
0.0	0.1	GO:0050904	diapedesis(GO:0050904)
0.0	0.1	GO:0060978	angiogenesis involved in coronary vascular morphogenesis(GO:0060978)
0.0	0.4	GO:1900037	regulation of cellular response to hypoxia(GO:1900037)
0.0	0.0	GO:2000587	regulation of platelet-derived growth factor receptor-beta signaling pathway(GO:2000586) negative regulation of platelet-derived growth factor receptor-beta signaling pathway(GO:2000587)
0.0	0.1	GO:0035461	vitamin transmembrane transport(GO:0035461)
0.0	0.1	GO:0035021	negative regulation of Rac protein signal transduction(GO:0035021)
0.0	0.1	GO:0000189	MAPK import into nucleus(GO:0000189)
0.0	0.1	GO:0010898	positive regulation of triglyceride catabolic process(GO:0010898)
0.0	0.1	GO:0006547	histidine metabolic process(GO:0006547)
0.0	0.1	GO:0071447	cellular response to hydroperoxide(GO:0071447)
0.0	0.1	GO:0046167	glycerol-3-phosphate biosynthetic process(GO:0046167)
0.0	0.1	GO:0060061	Spemann organizer formation(GO:0060061)
0.0	0.1	GO:0018879	biphenyl metabolic process(GO:0018879)
0.0	0.2	GO:0075522	IRES-dependent viral translational initiation(GO:0075522)
0.0	0.1	GO:0002018	renin-angiotensin regulation of aldosterone production(GO:0002018)
0.0	0.2	GO:0006729	tetrahydrobiopterin biosynthetic process(GO:0006729)
0.0	0.1	GO:0002034	regulation of blood vessel size by renin-angiotensin(GO:0002034) renal control of peripheral vascular resistance involved in regulation of systemic arterial blood pressure(GO:0003072)
0.0	0.1	GO:0061511	centriole elongation(GO:0061511)
0.0	0.1	GO:0019244	lactate biosynthetic process from pyruvate(GO:0019244) lactate biosynthetic process(GO:0019249)
0.0	0.1	GO:0071883	activation of MAPK activity by adrenergic receptor signaling pathway(GO:0071883)
0.0	0.1	GO:1990034	calcium ion export from cell(GO:1990034)
0.0	0.1	GO:0006106	fumarate metabolic process(GO:0006106)
0.0	0.1	GO:0051919	positive regulation of fibrinolysis(GO:0051919)
0.0	0.3	GO:0045324	late endosome to vacuole transport(GO:0045324)
0.0	0.1	GO:0036072	intramembranous ossification(GO:0001957) direct ossification(GO:0036072)
0.0	0.1	GO:0060112	generation of ovulation cycle rhythm(GO:0060112)
0.0	0.1	GO:0033762	response to glucagon(GO:0033762)
0.0	0.0	GO:0061535	glutamate secretion, neurotransmission(GO:0061535)
0.0	0.1	GO:0045650	negative regulation of macrophage differentiation(GO:0045650)
0.0	0.1	GO:1901844	regulation of cell communication by electrical coupling involved in cardiac conduction(GO:1901844)
0.0	0.1	GO:0070649	formin-nucleated actin cable assembly(GO:0070649)
0.0	0.1	GO:0035740	CD8-positive, alpha-beta T cell proliferation(GO:0035740) regulation of CD8-positive, alpha-beta T cell proliferation(GO:2000564)
0.0	0.1	GO:2000110	negative regulation of macrophage apoptotic process(GO:2000110)
0.0	0.0	GO:0048818	positive regulation of hair follicle maturation(GO:0048818)
0.0	0.1	GO:2000054	negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification(GO:2000054)
0.0	0.1	GO:0015888	thiamine transport(GO:0015888)
0.0	0.3	GO:0032516	positive regulation of phosphoprotein phosphatase activity(GO:0032516)
0.0	0.0	GO:2000053	regulation of Wnt signaling pathway involved in dorsal/ventral axis specification(GO:2000053)
0.0	0.0	GO:0010166	wax biosynthetic process(GO:0010025) wax metabolic process(GO:0010166)
0.0	0.1	GO:0045901	positive regulation of translational elongation(GO:0045901)
0.0	0.2	GO:0042118	endothelial cell activation(GO:0042118)
0.0	0.1	GO:0006046	N-acetylglucosamine catabolic process(GO:0006046)
0.0	0.0	GO:0072385	minus-end-directed organelle transport along microtubule(GO:0072385)
0.0	0.1	GO:0000414	regulation of histone H3-K36 methylation(GO:0000414)
0.0	0.4	GO:0032012	ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.0	0.0	GO:0070103	regulation of interleukin-6-mediated signaling pathway(GO:0070103)
0.0	0.1	GO:0046599	regulation of centriole replication(GO:0046599)
0.0	0.0	GO:1903336	negative regulation of vacuolar transport(GO:1903336)
0.0	0.1	GO:0045404	positive regulation of interleukin-4 biosynthetic process(GO:0045404)
0.0	0.1	GO:0021631	optic nerve morphogenesis(GO:0021631)
0.0	0.2	GO:0018026	peptidyl-lysine monomethylation(GO:0018026)
0.0	0.1	GO:0046855	inositol phosphate dephosphorylation(GO:0046855)
0.0	0.1	GO:0021555	midbrain-hindbrain boundary morphogenesis(GO:0021555)
0.0	0.0	GO:2000599	regulation of cyclin catabolic process(GO:2000598) negative regulation of cyclin catabolic process(GO:2000599)
0.0	0.1	GO:0046499	S-adenosylmethioninamine metabolic process(GO:0046499)
0.0	0.1	GO:0035963	response to interleukin-13(GO:0035962) cellular response to interleukin-13(GO:0035963)
0.0	0.0	GO:0071504	response to heparin(GO:0071503) cellular response to heparin(GO:0071504)
0.0	0.2	GO:0007603	phototransduction, visible light(GO:0007603)
0.0	0.1	GO:0051660	establishment of centrosome localization(GO:0051660)
0.0	0.0	GO:0021564	vagus nerve development(GO:0021564)
0.0	0.1	GO:0070345	negative regulation of fat cell proliferation(GO:0070345)
0.0	0.1	GO:0097680	double-strand break repair via classical nonhomologous end joining(GO:0097680)
0.0	0.1	GO:0051725	protein de-ADP-ribosylation(GO:0051725)
0.0	0.1	GO:0060398	regulation of growth hormone receptor signaling pathway(GO:0060398)
0.0	0.0	GO:0010825	positive regulation of centrosome duplication(GO:0010825)
0.0	0.2	GO:0001845	phagolysosome assembly(GO:0001845)
0.0	0.1	GO:0070779	D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
0.0	0.1	GO:0060178	regulation of exocyst localization(GO:0060178)
0.0	0.2	GO:0044090	positive regulation of vacuole organization(GO:0044090)
0.0	0.2	GO:0046606	negative regulation of centrosome duplication(GO:0010826) negative regulation of centrosome cycle(GO:0046606)
0.0	0.1	GO:0006104	succinyl-CoA metabolic process(GO:0006104)
0.0	0.1	GO:0070940	dephosphorylation of RNA polymerase II C-terminal domain(GO:0070940)
0.0	0.2	GO:0034498	early endosome to Golgi transport(GO:0034498)
0.0	0.4	GO:0033539	fatty acid beta-oxidation using acyl-CoA dehydrogenase(GO:0033539)
0.0	0.1	GO:0002553	histamine production involved in inflammatory response(GO:0002349) histamine secretion involved in inflammatory response(GO:0002441) histamine secretion by mast cell(GO:0002553)
0.0	0.1	GO:0042891	antibiotic transport(GO:0042891)
0.0	0.2	GO:2000651	positive regulation of sodium ion transmembrane transporter activity(GO:2000651)
0.0	0.1	GO:0001757	somite specification(GO:0001757)
0.0	0.1	GO:1904995	negative regulation of leukocyte adhesion to vascular endothelial cell(GO:1904995)
0.0	0.0	GO:0010725	regulation of primitive erythrocyte differentiation(GO:0010725)
0.0	0.4	GO:0000028	ribosomal small subunit assembly(GO:0000028)
0.0	0.1	GO:0006382	adenosine to inosine editing(GO:0006382)
0.0	0.1	GO:1903553	positive regulation of extracellular exosome assembly(GO:1903553)
0.0	0.1	GO:0000491	small nucleolar ribonucleoprotein complex assembly(GO:0000491) box C/D snoRNP assembly(GO:0000492)
0.0	0.0	GO:1902956	regulation of mitochondrial electron transport, NADH to ubiquinone(GO:1902956)
0.0	0.1	GO:0009750	response to fructose(GO:0009750)
0.0	0.1	GO:0060718	chorionic trophoblast cell differentiation(GO:0060718)
0.0	0.1	GO:0015808	L-alanine transport(GO:0015808)
0.0	0.1	GO:0036438	maintenance of lens transparency(GO:0036438)
0.0	0.1	GO:0051106	regulation of DNA ligation(GO:0051105) positive regulation of DNA ligation(GO:0051106)
0.0	0.0	GO:0097118	neuroligin clustering involved in postsynaptic membrane assembly(GO:0097118)
0.0	0.0	GO:0075509	receptor-mediated endocytosis of virus by host cell(GO:0019065) endocytosis involved in viral entry into host cell(GO:0075509)
0.0	0.2	GO:0033327	Leydig cell differentiation(GO:0033327)
0.0	0.0	GO:0060948	cardiac vascular smooth muscle cell development(GO:0060948)
0.0	0.1	GO:0046618	drug export(GO:0046618)
0.0	0.1	GO:0033121	regulation of purine nucleotide catabolic process(GO:0033121)
0.0	0.1	GO:0000350	generation of catalytic spliceosome for second transesterification step(GO:0000350)
0.0	0.0	GO:0007161	calcium-independent cell-matrix adhesion(GO:0007161)
0.0	0.1	GO:0005984	disaccharide metabolic process(GO:0005984)
0.0	0.1	GO:0042637	catagen(GO:0042637)
0.0	0.1	GO:0009448	gamma-aminobutyric acid metabolic process(GO:0009448)
0.0	0.2	GO:0006047	UDP-N-acetylglucosamine metabolic process(GO:0006047)
0.0	0.0	GO:0072309	mesenchymal stem cell maintenance involved in metanephric nephron morphogenesis(GO:0072309)
0.0	0.1	GO:0007296	vitellogenesis(GO:0007296)
0.0	0.0	GO:0060825	fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:0060825) regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:2000313)
0.0	0.4	GO:0006270	DNA replication initiation(GO:0006270)
0.0	0.1	GO:0045607	regulation of auditory receptor cell differentiation(GO:0045607) regulation of mechanoreceptor differentiation(GO:0045631) regulation of inner ear receptor cell differentiation(GO:2000980)
0.0	0.1	GO:0034499	late endosome to Golgi transport(GO:0034499)
0.0	0.1	GO:0008635	activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c(GO:0008635)
0.0	0.0	GO:0045974	negative regulation of translation, ncRNA-mediated(GO:0040033) regulation of translation, ncRNA-mediated(GO:0045974)
0.0	0.1	GO:2001046	positive regulation of integrin-mediated signaling pathway(GO:2001046)
0.0	0.1	GO:0051121	hepoxilin metabolic process(GO:0051121) hepoxilin biosynthetic process(GO:0051122)
0.0	0.0	GO:0061146	Peyer's patch morphogenesis(GO:0061146)
0.0	0.0	GO:0045626	negative regulation of T-helper 1 cell differentiation(GO:0045626)
0.0	0.1	GO:0014734	skeletal muscle hypertrophy(GO:0014734)
0.0	0.0	GO:0051611	negative regulation of neurotransmitter uptake(GO:0051581) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612)
0.0	0.1	GO:0030222	eosinophil differentiation(GO:0030222)
0.0	0.2	GO:0006857	oligopeptide transport(GO:0006857)
0.0	0.2	GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II(GO:0019886)
0.0	0.1	GO:0002741	positive regulation of cytokine secretion involved in immune response(GO:0002741)
0.0	0.0	GO:1903525	regulation of membrane tubulation(GO:1903525)
0.0	0.0	GO:0030242	pexophagy(GO:0030242)
0.0	0.0	GO:0019087	transformation of host cell by virus(GO:0019087)
0.0	0.1	GO:0035912	dorsal aorta development(GO:0035907) dorsal aorta morphogenesis(GO:0035912)
0.0	0.0	GO:1901628	positive regulation of postsynaptic membrane organization(GO:1901628)
0.0	0.0	GO:0002159	desmosome assembly(GO:0002159)
0.0	0.0	GO:0034395	regulation of transcription from RNA polymerase II promoter in response to iron(GO:0034395)
0.0	0.2	GO:2000114	regulation of establishment of cell polarity(GO:2000114)
0.0	0.1	GO:0032000	positive regulation of fatty acid beta-oxidation(GO:0032000)
0.0	0.1	GO:0002091	negative regulation of receptor internalization(GO:0002091)
0.0	0.0	GO:0016259	selenocysteine metabolic process(GO:0016259)
0.0	0.2	GO:0009143	nucleoside triphosphate catabolic process(GO:0009143)
0.0	0.0	GO:0090526	regulation of gluconeogenesis involved in cellular glucose homeostasis(GO:0090526)
0.0	0.0	GO:1903416	response to glycoside(GO:1903416)
0.0	0.0	GO:0001927	exocyst assembly(GO:0001927)
0.0	0.2	GO:2001241	positive regulation of extrinsic apoptotic signaling pathway in absence of ligand(GO:2001241)
0.0	0.0	GO:1902268	negative regulation of polyamine transmembrane transport(GO:1902268)
0.0	0.1	GO:0072584	caveolin-mediated endocytosis(GO:0072584)
0.0	0.1	GO:0061042	vascular wound healing(GO:0061042)
0.0	0.2	GO:0030502	negative regulation of bone mineralization(GO:0030502)
0.0	0.0	GO:0034163	regulation of toll-like receptor 9 signaling pathway(GO:0034163) positive regulation of toll-like receptor 9 signaling pathway(GO:0034165)
0.0	0.0	GO:0006296	nucleotide-excision repair, DNA incision, 5'-to lesion(GO:0006296)
0.0	0.1	GO:0061302	smooth muscle cell-matrix adhesion(GO:0061302)
0.0	0.1	GO:0042905	9-cis-retinoic acid biosynthetic process(GO:0042904) 9-cis-retinoic acid metabolic process(GO:0042905)
0.0	0.0	GO:0060762	regulation of branching involved in mammary gland duct morphogenesis(GO:0060762)
0.0	0.1	GO:1904259	regulation of basement membrane assembly involved in embryonic body morphogenesis(GO:1904259) positive regulation of basement membrane assembly involved in embryonic body morphogenesis(GO:1904261) basement membrane assembly involved in embryonic body morphogenesis(GO:2001197)
0.0	0.1	GO:0015871	choline transport(GO:0015871)
0.0	0.0	GO:0051902	negative regulation of mitochondrial depolarization(GO:0051902) negative regulation of membrane depolarization(GO:1904180)
0.0	0.0	GO:0042138	meiotic DNA double-strand break formation(GO:0042138)
0.0	0.0	GO:1902498	regulation of protein autoubiquitination(GO:1902498)
0.0	0.0	GO:0001880	Mullerian duct regression(GO:0001880)
0.0	0.3	GO:0036075	endochondral ossification(GO:0001958) replacement ossification(GO:0036075)
0.0	0.0	GO:1902414	protein localization to cell junction(GO:1902414)
0.0	0.0	GO:0061031	endodermal digestive tract morphogenesis(GO:0061031)
0.0	0.3	GO:0045197	establishment or maintenance of epithelial cell apical/basal polarity(GO:0045197)
0.0	0.0	GO:0042504	tyrosine phosphorylation of Stat4 protein(GO:0042504) regulation of tyrosine phosphorylation of Stat4 protein(GO:0042519)
0.0	0.0	GO:1900108	negative regulation of nodal signaling pathway(GO:1900108)
0.0	0.2	GO:0060074	synapse maturation(GO:0060074)
0.0	0.1	GO:0050861	positive regulation of B cell receptor signaling pathway(GO:0050861)
0.0	0.0	GO:0035887	aortic smooth muscle cell differentiation(GO:0035887)
0.0	0.0	GO:0002337	B-1a B cell differentiation(GO:0002337)
0.0	0.0	GO:1900451	positive regulation of glutamate receptor signaling pathway(GO:1900451) positive regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000969)
0.0	0.1	GO:0042271	susceptibility to natural killer cell mediated cytotoxicity(GO:0042271)
0.0	0.1	GO:0010572	positive regulation of platelet activation(GO:0010572)
0.0	0.0	GO:0035426	extracellular matrix-cell signaling(GO:0035426)
0.0	0.1	GO:0090043	regulation of tubulin deacetylation(GO:0090043)
0.0	0.4	GO:0090662	energy coupled proton transmembrane transport, against electrochemical gradient(GO:0015988) ATP hydrolysis coupled proton transport(GO:0015991) ATP hydrolysis coupled transmembrane transport(GO:0090662)
0.0	0.0	GO:0002378	immunoglobulin biosynthetic process(GO:0002378)
0.0	0.0	GO:0061366	behavioral response to chemical pain(GO:0061366) behavioral response to formalin induced pain(GO:0061368)
0.0	0.0	GO:0035880	embryonic nail plate morphogenesis(GO:0035880)
0.0	0.1	GO:0060750	epithelial cell proliferation involved in mammary gland duct elongation(GO:0060750)
0.0	0.2	GO:0015813	L-glutamate transport(GO:0015813)
0.0	0.2	GO:0003351	epithelial cilium movement(GO:0003351)
0.0	0.1	GO:0006348	chromatin silencing at telomere(GO:0006348)
0.0	0.0	GO:0097167	circadian regulation of translation(GO:0097167)
0.0	0.0	GO:0060264	regulation of respiratory burst involved in inflammatory response(GO:0060264)
0.0	0.1	GO:0006528	asparagine metabolic process(GO:0006528)
0.0	0.0	GO:0060300	regulation of cytokine activity(GO:0060300)
0.0	0.1	GO:0043312	neutrophil degranulation(GO:0043312)
0.0	0.1	GO:0007135	meiosis II(GO:0007135)
0.0	0.0	GO:0071677	positive regulation of mononuclear cell migration(GO:0071677)
0.0	0.1	GO:0030259	lipid glycosylation(GO:0030259)
0.0	0.0	GO:0000019	regulation of mitotic recombination(GO:0000019)
0.0	0.1	GO:0086036	regulation of cardiac muscle cell membrane potential(GO:0086036)
0.0	0.1	GO:0043570	maintenance of DNA repeat elements(GO:0043570)
0.0	0.1	GO:0045900	negative regulation of translational elongation(GO:0045900)
0.0	0.2	GO:0042059	negative regulation of epidermal growth factor receptor signaling pathway(GO:0042059)
0.0	0.1	GO:0090400	stress-induced premature senescence(GO:0090400)
0.0	0.2	GO:0046641	positive regulation of alpha-beta T cell proliferation(GO:0046641)
0.0	0.1	GO:0060391	positive regulation of SMAD protein import into nucleus(GO:0060391)
0.0	0.0	GO:0035511	oxidative DNA demethylation(GO:0035511)
0.0	0.0	GO:2000468	regulation of peroxidase activity(GO:2000468)
0.0	0.0	GO:0021764	amygdala development(GO:0021764)
0.0	0.0	GO:0006297	nucleotide-excision repair, DNA gap filling(GO:0006297)
0.0	0.0	GO:0071205	protein localization to juxtaparanode region of axon(GO:0071205)
0.0	0.1	GO:0015727	lactate transport(GO:0015727) lactate transmembrane transport(GO:0035873) plasma membrane lactate transport(GO:0035879)
0.0	0.1	GO:0060242	contact inhibition(GO:0060242)
0.0	0.0	GO:0046838	phosphorylated carbohydrate dephosphorylation(GO:0046838)
0.0	0.2	GO:0030212	hyaluronan metabolic process(GO:0030212)
0.0	0.0	GO:0001907	killing by symbiont of host cells(GO:0001907) disruption by symbiont of host cell(GO:0044004)
0.0	0.0	GO:0090324	negative regulation of oxidative phosphorylation(GO:0090324)
0.0	0.2	GO:0035994	response to muscle stretch(GO:0035994)
0.0	0.0	GO:0097477	lateral motor column neuron migration(GO:0097477)
0.0	0.1	GO:0015695	organic cation transport(GO:0015695)
0.0	0.3	GO:0008631	intrinsic apoptotic signaling pathway in response to oxidative stress(GO:0008631)
0.0	0.0	GO:0051895	negative regulation of focal adhesion assembly(GO:0051895)
0.0	0.1	GO:0048280	vesicle fusion with Golgi apparatus(GO:0048280)
0.0	0.0	GO:0031508	pericentric heterochromatin assembly(GO:0031508)
0.0	0.2	GO:0046856	phosphatidylinositol dephosphorylation(GO:0046856)
0.0	0.0	GO:1903847	regulation of aorta morphogenesis(GO:1903847) positive regulation of aorta morphogenesis(GO:1903849)
0.0	0.1	GO:0045743	positive regulation of fibroblast growth factor receptor signaling pathway(GO:0045743)
0.0	0.1	GO:0021891	olfactory bulb interneuron development(GO:0021891)
0.0	0.0	GO:0035360	positive regulation of peroxisome proliferator activated receptor signaling pathway(GO:0035360)
0.0	0.0	GO:0009446	putrescine biosynthetic process(GO:0009446)
0.0	0.1	GO:0007016	cytoskeletal anchoring at plasma membrane(GO:0007016)
0.0	0.1	GO:0007638	mechanosensory behavior(GO:0007638)
0.0	0.0	GO:0070340	detection of bacterial lipopeptide(GO:0070340)
0.0	0.0	GO:0070782	phosphatidylserine exposure on apoptotic cell surface(GO:0070782)
0.0	0.0	GO:0060159	regulation of dopamine receptor signaling pathway(GO:0060159)
0.0	0.0	GO:0034154	toll-like receptor 7 signaling pathway(GO:0034154)
0.0	0.0	GO:0036493	positive regulation of translation in response to endoplasmic reticulum stress(GO:0036493)
0.0	0.1	GO:0050860	negative regulation of T cell receptor signaling pathway(GO:0050860)
0.0	0.1	GO:0072102	glomerulus morphogenesis(GO:0072102)
0.0	0.0	GO:0090148	membrane fission(GO:0090148)
0.0	0.2	GO:0034308	primary alcohol metabolic process(GO:0034308)
0.0	0.0	GO:0000733	DNA strand renaturation(GO:0000733)
0.0	0.0	GO:0000960	mitochondrial RNA catabolic process(GO:0000957) regulation of mitochondrial RNA catabolic process(GO:0000960)
0.0	0.1	GO:0042359	vitamin D metabolic process(GO:0042359)
0.0	0.0	GO:1903392	negative regulation of adherens junction organization(GO:1903392)
0.0	0.0	GO:0008354	germ cell migration(GO:0008354)
0.0	0.0	GO:0060931	sinoatrial node cell development(GO:0060931)
0.0	0.0	GO:0046292	formaldehyde metabolic process(GO:0046292)
0.0	0.0	GO:0044791	modulation by host of viral release from host cell(GO:0044789) positive regulation by host of viral release from host cell(GO:0044791)
0.0	0.0	GO:2000491	positive regulation of hepatic stellate cell activation(GO:2000491)
0.0	0.2	GO:0042832	defense response to protozoan(GO:0042832)
0.0	0.0	GO:2001032	regulation of double-strand break repair via nonhomologous end joining(GO:2001032)
0.0	0.0	GO:0006059	hexitol metabolic process(GO:0006059)
0.0	0.0	GO:0042769	DNA damage response, detection of DNA damage(GO:0042769)
0.0	0.0	GO:0021869	forebrain ventricular zone progenitor cell division(GO:0021869)
0.0	0.0	GO:0021800	cerebral cortex tangential migration(GO:0021800)
0.0	0.1	GO:0090162	establishment of epithelial cell polarity(GO:0090162)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.4	GO:0005658	alpha DNA polymerase:primase complex(GO:0005658)
0.1	0.8	GO:0005577	fibrinogen complex(GO:0005577)
0.1	0.3	GO:0097427	microtubule bundle(GO:0097427)
0.1	0.7	GO:0033180	proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.1	0.4	GO:0034363	intermediate-density lipoprotein particle(GO:0034363)
0.1	0.2	GO:0034666	integrin alpha2-beta1 complex(GO:0034666)
0.1	0.4	GO:0031232	extrinsic component of external side of plasma membrane(GO:0031232)
0.1	0.2	GO:0097451	glial limiting end-foot(GO:0097451)
0.1	0.2	GO:0005899	insulin receptor complex(GO:0005899)
0.1	0.2	GO:0009279	cell outer membrane(GO:0009279) cell envelope(GO:0030313) external encapsulating structure part(GO:0044462)
0.0	0.5	GO:0046581	intercellular canaliculus(GO:0046581)
0.0	0.2	GO:0000931	gamma-tubulin large complex(GO:0000931) gamma-tubulin ring complex(GO:0008274)
0.0	0.4	GO:0002116	semaphorin receptor complex(GO:0002116)
0.0	0.3	GO:0071437	invadopodium(GO:0071437)
0.0	0.1	GO:0097025	MPP7-DLG1-LIN7 complex(GO:0097025)
0.0	0.1	GO:0036449	microtubule minus-end(GO:0036449)
0.0	0.2	GO:0070937	CRD-mediated mRNA stability complex(GO:0070937)
0.0	0.1	GO:0045251	mitochondrial electron transfer flavoprotein complex(GO:0017133) electron transfer flavoprotein complex(GO:0045251)
0.0	0.2	GO:0016461	unconventional myosin complex(GO:0016461)
0.0	0.3	GO:0000815	ESCRT III complex(GO:0000815)
0.0	0.2	GO:0008290	F-actin capping protein complex(GO:0008290)
0.0	0.2	GO:0000788	nuclear nucleosome(GO:0000788)
0.0	0.1	GO:0043293	apoptosome(GO:0043293)
0.0	0.2	GO:0042627	chylomicron(GO:0042627)
0.0	0.1	GO:0005745	m-AAA complex(GO:0005745)
0.0	0.1	GO:1990604	IRE1-TRAF2-ASK1 complex(GO:1990604)
0.0	0.2	GO:0070419	nonhomologous end joining complex(GO:0070419)
0.0	0.1	GO:0031467	Cul7-RING ubiquitin ligase complex(GO:0031467)
0.0	0.3	GO:0005916	fascia adherens(GO:0005916)
0.0	0.1	GO:0097057	TRAF2-GSTP1 complex(GO:0097057)
0.0	0.2	GO:0042613	MHC class II protein complex(GO:0042613)
0.0	0.0	GO:1990597	AIP1-IRE1 complex(GO:1990597)
0.0	0.3	GO:0016600	flotillin complex(GO:0016600)
0.0	0.2	GO:0031931	TORC1 complex(GO:0031931)
0.0	0.3	GO:0031143	pseudopodium(GO:0031143)
0.0	0.2	GO:0042622	photoreceptor outer segment membrane(GO:0042622)
0.0	0.1	GO:0030062	mitochondrial tricarboxylic acid cycle enzyme complex(GO:0030062)
0.0	0.3	GO:0098533	ATPase dependent transmembrane transport complex(GO:0098533)
0.0	0.1	GO:0005642	annulate lamellae(GO:0005642)
0.0	0.0	GO:0071664	catenin-TCF7L2 complex(GO:0071664)
0.0	0.1	GO:0061574	ASAP complex(GO:0061574)
0.0	0.2	GO:0042405	nuclear inclusion body(GO:0042405)
0.0	0.5	GO:0030665	clathrin-coated vesicle membrane(GO:0030665)
0.0	0.1	GO:0061700	GATOR2 complex(GO:0061700)
0.0	0.1	GO:0000138	Golgi trans cisterna(GO:0000138)
0.0	0.1	GO:0005593	FACIT collagen trimer(GO:0005593)
0.0	0.1	GO:0031465	Cul4B-RING E3 ubiquitin ligase complex(GO:0031465)
0.0	0.5	GO:0032281	AMPA glutamate receptor complex(GO:0032281)
0.0	0.5	GO:0000307	cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.0	1.0	GO:0000932	cytoplasmic mRNA processing body(GO:0000932)
0.0	0.0	GO:0097454	Schwann cell microvillus(GO:0097454)
0.0	0.1	GO:0005638	lamin filament(GO:0005638)
0.0	0.2	GO:0005766	primary lysosome(GO:0005766) azurophil granule(GO:0042582)
0.0	0.1	GO:0045179	apical cortex(GO:0045179)
0.0	0.0	GO:0070522	ERCC4-ERCC1 complex(GO:0070522)
0.0	0.4	GO:0030687	preribosome, large subunit precursor(GO:0030687)
0.0	0.5	GO:0009925	basal plasma membrane(GO:0009925)
0.0	0.1	GO:0020005	symbiont-containing vacuole membrane(GO:0020005)
0.0	0.1	GO:0070695	FHF complex(GO:0070695)
0.0	0.1	GO:0044224	juxtaparanode region of axon(GO:0044224)
0.0	0.1	GO:0005826	actomyosin contractile ring(GO:0005826)
0.0	0.1	GO:0031512	motile primary cilium(GO:0031512)
0.0	0.1	GO:0097539	ciliary transition fiber(GO:0097539)
0.0	0.0	GO:0071008	U2-type post-mRNA release spliceosomal complex(GO:0071008)
0.0	0.0	GO:0070110	ciliary neurotrophic factor receptor complex(GO:0070110)
0.0	0.0	GO:0065010	extracellular membrane-bounded organelle(GO:0065010)
0.0	0.2	GO:0030904	retromer complex(GO:0030904)
0.0	0.0	GO:0034457	Mpp10 complex(GO:0034457)
0.0	0.1	GO:0005796	Golgi lumen(GO:0005796)
0.0	0.0	GO:0034679	integrin alpha9-beta1 complex(GO:0034679)
0.0	0.0	GO:0030870	Mre11 complex(GO:0030870)
0.0	0.0	GO:0030981	cortical microtubule cytoskeleton(GO:0030981)
0.0	0.1	GO:0031045	dense core granule(GO:0031045)
0.0	0.0	GO:0009331	glycerol-3-phosphate dehydrogenase complex(GO:0009331)
0.0	0.2	GO:0043034	costamere(GO:0043034)
0.0	0.1	GO:0036038	MKS complex(GO:0036038)
0.0	0.0	GO:0097136	Bcl-2 family protein complex(GO:0097136)
0.0	0.6	GO:0032587	ruffle membrane(GO:0032587)
0.0	0.0	GO:0005850	eukaryotic translation initiation factor 2 complex(GO:0005850)
0.0	0.0	GO:0031417	NatC complex(GO:0031417)
0.0	0.2	GO:0031231	intrinsic component of peroxisomal membrane(GO:0031231)
0.0	0.0	GO:0000172	ribonuclease MRP complex(GO:0000172)
0.0	0.0	GO:0044614	nuclear pore cytoplasmic filaments(GO:0044614)
0.0	0.1	GO:0005677	chromatin silencing complex(GO:0005677)
0.0	0.0	GO:0005853	eukaryotic translation elongation factor 1 complex(GO:0005853)
0.0	0.1	GO:0001520	outer dense fiber(GO:0001520)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	0.5	GO:0015186	L-asparagine transmembrane transporter activity(GO:0015182) L-glutamine transmembrane transporter activity(GO:0015186)
0.1	0.4	GO:0008525	phosphatidylcholine transporter activity(GO:0008525)
0.1	0.6	GO:0043184	vascular endothelial growth factor receptor 2 binding(GO:0043184)
0.1	0.3	GO:0070644	vitamin D response element binding(GO:0070644)
0.1	0.3	GO:0030350	iron-responsive element binding(GO:0030350)
0.1	0.3	GO:0004949	cannabinoid receptor activity(GO:0004949)
0.1	0.5	GO:0047035	testosterone dehydrogenase (NAD+) activity(GO:0047035)
0.1	0.4	GO:0016726	xanthine dehydrogenase activity(GO:0004854) oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor(GO:0016726)
0.1	0.6	GO:0018448	pinocarveol dehydrogenase activity(GO:0018446) chloral hydrate dehydrogenase activity(GO:0018447) hydroxymethylmethylsilanediol oxidase activity(GO:0018448) 1-phenylethanol dehydrogenase activity(GO:0018449) myrtenol dehydrogenase activity(GO:0018450) cis-1,2-dihydroxy-1,2-dihydro-8-carboxynaphthalene dehydrogenase activity(GO:0034522) 3-hydroxy-4-methyloctanoyl-CoA dehydrogenase activity(GO:0034582) 2-hydroxy-4-isopropenylcyclohexane-1-carboxyl-CoA dehydrogenase activity(GO:0034778) cis-9,10-dihydroanthracene-9,10-diol dehydrogenase activity(GO:0034817) citronellol dehydrogenase activity(GO:0034821) naphthyl-2-hydroxymethyl-succinyl-CoA dehydrogenase activity(GO:0034847) 2,4,4-trimethyl-1-pentanol dehydrogenase activity(GO:0034863) 2,4,4-trimethyl-3-hydroxypentanoyl-CoA dehydrogenase activity(GO:0034868) 1-hydroxy-4,4-dimethylpentan-3-one dehydrogenase activity(GO:0034871) endosulfan diol dehydrogenase activity(GO:0034891) endosulfan hydroxyether dehydrogenase activity(GO:0034901) 3-hydroxy-2-methylhexanoyl-CoA dehydrogenase activity(GO:0034918) 3-hydroxy-2,6-dimethyl-5-methylene-heptanoyl-CoA dehydrogenase activity(GO:0034944) versicolorin reductase activity(GO:0042469) ketoreductase activity(GO:0045703)
0.1	0.5	GO:1990459	transferrin receptor binding(GO:1990459)
0.1	0.4	GO:0005225	volume-sensitive anion channel activity(GO:0005225)
0.1	0.4	GO:0008390	testosterone 16-alpha-hydroxylase activity(GO:0008390)
0.1	0.3	GO:0070290	N-acylphosphatidylethanolamine-specific phospholipase D activity(GO:0070290)
0.1	0.3	GO:0030976	thiamine pyrophosphate binding(GO:0030976)
0.1	0.4	GO:0018647	3-(3-hydroxyphenyl)propionate hydroxylase activity(GO:0008688) 4-chlorobenzaldehyde oxidase activity(GO:0018471) 3,5-xylenol methylhydroxylase activity(GO:0018630) phenylacetate hydroxylase activity(GO:0018631) 4-nitrophenol 4-monooxygenase activity(GO:0018632) dimethyl sulfide monooxygenase activity(GO:0018633) alpha-pinene monooxygenase [NADH] activity(GO:0018634) 1-hydroxy-2-naphthoate hydroxylase activity(GO:0018637) toluene 4-monooxygenase activity(GO:0018638) xylene monooxygenase activity(GO:0018639) dibenzothiophene monooxygenase activity(GO:0018640) 6-hydroxy-3-methyl-2-oxo-1,2-dihydroquinoline 6-monooxygenase activity(GO:0018641) chlorophenol 4-monooxygenase activity(GO:0018642) carbon disulfide oxygenase activity(GO:0018643) toluene 2-monooxygenase activity(GO:0018644) 1-hydroxy-2-oxolimonene 1,2-monooxygenase activity(GO:0018646) phenanthrene 1,2-monooxygenase activity(GO:0018647) tetrahydrofuran hydroxylase activity(GO:0018649) styrene monooxygenase activity(GO:0018650) toluene-4-sulfonate monooxygenase activity(GO:0018651) toluene-sulfonate methyl-monooxygenase activity(GO:0018652) 3-methyl-2-oxo-1,2-dihydroquinoline 6-monooxygenase activity(GO:0018653) 2-hydroxy-phenylacetate hydroxylase activity(GO:0018654) 2-oxo-delta3-4,5,5-trimethylcyclopentenylacetyl-CoA 1,2-monooxygenase activity(GO:0018655) phenanthrene 3,4-monooxygenase activity(GO:0018656) toluene 3-monooxygenase activity(GO:0018657) 4-hydroxyphenylacetate,NADH:oxygen oxidoreductase (3-hydroxylating) activity(GO:0018660) limonene monooxygenase activity(GO:0019113) 2-methylnaphthalene hydroxylase activity(GO:0034526) 1-methylnaphthalene hydroxylase activity(GO:0034534) bisphenol A hydroxylase A activity(GO:0034560) salicylate 5-hydroxylase activity(GO:0034785) isobutylamine N-hydroxylase activity(GO:0034791) branched-chain dodecylbenzene sulfonate monooxygenase activity(GO:0034802) 3-HSA hydroxylase activity(GO:0034819) 4-hydroxypyridine-3-hydroxylase activity(GO:0034894) 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase activity(GO:0043719) 6-hydroxynicotinate 3-monooxygenase activity(GO:0043731) thalianol hydroxylase activity(GO:0080014)
0.1	0.2	GO:0005128	erythropoietin receptor binding(GO:0005128)
0.1	0.2	GO:0003985	acetyl-CoA C-acetyltransferase activity(GO:0003985) C-acetyltransferase activity(GO:0016453)
0.1	0.3	GO:0035473	lipase binding(GO:0035473)
0.1	0.2	GO:0051575	5'-deoxyribose-5-phosphate lyase activity(GO:0051575)
0.0	0.6	GO:0008553	hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.0	0.4	GO:0031995	insulin-like growth factor II binding(GO:0031995)
0.0	0.5	GO:0017154	semaphorin receptor activity(GO:0017154)
0.0	0.2	GO:0045340	mercury ion binding(GO:0045340)
0.0	0.1	GO:0070653	high-density lipoprotein particle receptor binding(GO:0070653)
0.0	0.3	GO:0003680	AT DNA binding(GO:0003680)
0.0	0.2	GO:0047391	alkylglycerophosphoethanolamine phosphodiesterase activity(GO:0047391)
0.0	0.4	GO:0048027	mRNA 5'-UTR binding(GO:0048027)
0.0	0.1	GO:0001875	lipopolysaccharide receptor activity(GO:0001875)
0.0	0.3	GO:0005384	manganese ion transmembrane transporter activity(GO:0005384)
0.0	0.2	GO:0090482	vitamin transmembrane transporter activity(GO:0090482)
0.0	0.2	GO:0016004	phospholipase activator activity(GO:0016004)
0.0	0.1	GO:0016823	hydrolase activity, acting on acid carbon-carbon bonds(GO:0016822) hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances(GO:0016823)
0.0	0.2	GO:0030292	protein tyrosine kinase inhibitor activity(GO:0030292)
0.0	0.2	GO:0000014	single-stranded DNA endodeoxyribonuclease activity(GO:0000014)
0.0	0.1	GO:0004699	calcium-independent protein kinase C activity(GO:0004699)
0.0	0.1	GO:0016309	1-phosphatidylinositol-5-phosphate 4-kinase activity(GO:0016309)
0.0	0.1	GO:0019166	trans-2-enoyl-CoA reductase (NADPH) activity(GO:0019166)
0.0	0.1	GO:0030984	kininogen binding(GO:0030984)
0.0	0.0	GO:0060229	lipase activator activity(GO:0060229)
0.0	0.5	GO:0034185	apolipoprotein binding(GO:0034185)
0.0	0.3	GO:0004774	succinate-CoA ligase activity(GO:0004774)
0.0	0.6	GO:0043274	phospholipase binding(GO:0043274)
0.0	0.2	GO:0050897	cobalt ion binding(GO:0050897)
0.0	0.2	GO:0086080	protein binding involved in heterotypic cell-cell adhesion(GO:0086080)
0.0	0.2	GO:0015198	oligopeptide transporter activity(GO:0015198)
0.0	0.1	GO:0003886	DNA (cytosine-5-)-methyltransferase activity(GO:0003886) DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates(GO:0051718)
0.0	0.1	GO:0016018	cyclosporin A binding(GO:0016018)
0.0	0.2	GO:0050051	leukotriene-B4 20-monooxygenase activity(GO:0050051)
0.0	0.1	GO:0042895	antibiotic transporter activity(GO:0042895)
0.0	0.2	GO:0047499	calcium-independent phospholipase A2 activity(GO:0047499)
0.0	0.1	GO:0055100	adiponectin binding(GO:0055100)
0.0	0.1	GO:0070840	dynein complex binding(GO:0070840)
0.0	0.1	GO:0098632	protein binding involved in cell-cell adhesion(GO:0098632)
0.0	0.3	GO:0010314	phosphatidylinositol-5-phosphate binding(GO:0010314)
0.0	0.5	GO:0032266	phosphatidylinositol-3-phosphate binding(GO:0032266)
0.0	0.1	GO:0071253	connexin binding(GO:0071253)
0.0	0.1	GO:0004459	L-lactate dehydrogenase activity(GO:0004459)
0.0	0.1	GO:0080130	L-phenylalanine:2-oxoglutarate aminotransferase activity(GO:0080130)
0.0	0.1	GO:0000268	peroxisome targeting sequence binding(GO:0000268)
0.0	0.2	GO:0008494	translation activator activity(GO:0008494)
0.0	0.2	GO:0070991	medium-chain-acyl-CoA dehydrogenase activity(GO:0070991)
0.0	0.3	GO:0031434	mitogen-activated protein kinase kinase binding(GO:0031434)
0.0	0.1	GO:0015093	ferrous iron transmembrane transporter activity(GO:0015093)
0.0	0.1	GO:0016841	ammonia-lyase activity(GO:0016841)
0.0	0.3	GO:0001618	virus receptor activity(GO:0001618)
0.0	0.1	GO:0052650	NADP-retinol dehydrogenase activity(GO:0052650)
0.0	0.1	GO:0038132	neuregulin binding(GO:0038132)
0.0	0.2	GO:0004438	phosphatidylinositol-3-phosphatase activity(GO:0004438)
0.0	0.2	GO:0034046	poly(G) binding(GO:0034046)
0.0	0.1	GO:0035368	selenocysteine insertion sequence binding(GO:0035368)
0.0	0.2	GO:0050291	sphingosine N-acyltransferase activity(GO:0050291)
0.0	0.1	GO:0042134	rRNA primary transcript binding(GO:0042134)
0.0	0.0	GO:0097016	L27 domain binding(GO:0097016)
0.0	0.2	GO:0001091	RNA polymerase II basal transcription factor binding(GO:0001091)
0.0	0.1	GO:0046912	transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
0.0	0.1	GO:0015220	choline transmembrane transporter activity(GO:0015220)
0.0	0.2	GO:0051011	microtubule minus-end binding(GO:0051011)
0.0	0.2	GO:0032795	heterotrimeric G-protein binding(GO:0032795)
0.0	0.1	GO:0050508	glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity(GO:0050508)
0.0	0.4	GO:0016646	oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor(GO:0016646)
0.0	0.1	GO:0004370	glycerol kinase activity(GO:0004370)
0.0	0.1	GO:0008532	N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity(GO:0008532)
0.0	0.2	GO:0005313	L-glutamate transmembrane transporter activity(GO:0005313)
0.0	0.1	GO:0019960	C-X3-C chemokine binding(GO:0019960)
0.0	0.3	GO:0015238	drug transmembrane transporter activity(GO:0015238)
0.0	0.1	GO:0015038	glutathione disulfide oxidoreductase activity(GO:0015038)
0.0	0.1	GO:0017127	cholesterol transporter activity(GO:0017127)
0.0	0.0	GO:0035615	clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)
0.0	0.0	GO:0032139	dinucleotide insertion or deletion binding(GO:0032139)
0.0	0.2	GO:0005391	sodium:potassium-exchanging ATPase activity(GO:0005391)
0.0	0.1	GO:0043398	HLH domain binding(GO:0043398)
0.0	0.1	GO:0005005	transmembrane-ephrin receptor activity(GO:0005005)
0.0	0.1	GO:0015379	potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820)
0.0	1.0	GO:0032947	protein complex scaffold(GO:0032947)
0.0	0.2	GO:0043024	ribosomal small subunit binding(GO:0043024)
0.0	0.1	GO:0005329	dopamine transmembrane transporter activity(GO:0005329)
0.0	0.1	GO:0018585	fluorene oxygenase activity(GO:0018585)
0.0	0.1	GO:0005499	vitamin D binding(GO:0005499)
0.0	0.1	GO:0051864	histone demethylase activity (H3-K36 specific)(GO:0051864)
0.0	0.2	GO:0004445	inositol-polyphosphate 5-phosphatase activity(GO:0004445)
0.0	0.0	GO:0004103	choline kinase activity(GO:0004103)
0.0	0.1	GO:0016920	pyroglutamyl-peptidase activity(GO:0016920)
0.0	0.1	GO:0019808	polyamine binding(GO:0019808)
0.0	0.1	GO:0052834	inositol monophosphate 1-phosphatase activity(GO:0008934) inositol monophosphate 3-phosphatase activity(GO:0052832) inositol monophosphate 4-phosphatase activity(GO:0052833) inositol monophosphate phosphatase activity(GO:0052834)
0.0	0.0	GO:0031726	CCR1 chemokine receptor binding(GO:0031726)
0.0	0.1	GO:0008429	phosphatidylethanolamine binding(GO:0008429)
0.0	0.0	GO:0016401	palmitoyl-CoA oxidase activity(GO:0016401)
0.0	0.1	GO:0016889	endodeoxyribonuclease activity, producing 3'-phosphomonoesters(GO:0016889)
0.0	0.0	GO:0004461	lactose synthase activity(GO:0004461)
0.0	0.1	GO:0016742	hydroxymethyl-, formyl- and related transferase activity(GO:0016742)
0.0	0.1	GO:0022858	L-alanine transmembrane transporter activity(GO:0015180) alanine transmembrane transporter activity(GO:0022858)
0.0	0.1	GO:0008889	glycerophosphodiester phosphodiesterase activity(GO:0008889)
0.0	0.4	GO:0003887	DNA-directed DNA polymerase activity(GO:0003887)
0.0	0.2	GO:0031005	filamin binding(GO:0031005)
0.0	0.0	GO:0008073	ornithine decarboxylase inhibitor activity(GO:0008073)
0.0	0.0	GO:0061513	hexose phosphate transmembrane transporter activity(GO:0015119) organophosphate:inorganic phosphate antiporter activity(GO:0015315) hexose-phosphate:inorganic phosphate antiporter activity(GO:0015526) glucose 6-phosphate:inorganic phosphate antiporter activity(GO:0061513)
0.0	0.1	GO:0032027	myosin light chain binding(GO:0032027)
0.0	0.1	GO:0015165	pyrimidine nucleotide-sugar transmembrane transporter activity(GO:0015165)
0.0	0.1	GO:0003953	NAD+ nucleosidase activity(GO:0003953)
0.0	0.0	GO:0036137	kynurenine-oxoglutarate transaminase activity(GO:0016212) kynurenine aminotransferase activity(GO:0036137)
0.0	0.1	GO:0003910	DNA ligase activity(GO:0003909) DNA ligase (ATP) activity(GO:0003910)
0.0	0.1	GO:0032184	SUMO polymer binding(GO:0032184)
0.0	0.3	GO:0005086	ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.0	0.1	GO:0050649	testosterone 6-beta-hydroxylase activity(GO:0050649)
0.0	0.0	GO:0070698	type I activin receptor binding(GO:0070698)
0.0	0.1	GO:0000386	second spliceosomal transesterification activity(GO:0000386)
0.0	0.1	GO:0009374	biotin binding(GO:0009374)
0.0	0.0	GO:0047276	N-acetyllactosaminide 3-alpha-galactosyltransferase activity(GO:0047276)
0.0	0.1	GO:0004301	epoxide hydrolase activity(GO:0004301)
0.0	0.1	GO:0004468	lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468)
0.0	0.0	GO:0004720	protein-lysine 6-oxidase activity(GO:0004720)
0.0	0.1	GO:0008190	eukaryotic initiation factor 4E binding(GO:0008190)
0.0	0.0	GO:0016015	morphogen activity(GO:0016015)
0.0	0.1	GO:0000403	Y-form DNA binding(GO:0000403)
0.0	0.0	GO:0004965	G-protein coupled GABA receptor activity(GO:0004965)
0.0	0.1	GO:0004017	adenylate kinase activity(GO:0004017)
0.0	0.0	GO:0003976	UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity(GO:0003976)
0.0	0.1	GO:0031702	type 1 angiotensin receptor binding(GO:0031702)
0.0	0.0	GO:0035514	DNA demethylase activity(GO:0035514)
0.0	0.2	GO:0030215	semaphorin receptor binding(GO:0030215)
0.0	0.1	GO:0031748	D1 dopamine receptor binding(GO:0031748)
0.0	0.1	GO:0015129	lactate transmembrane transporter activity(GO:0015129)
0.0	0.2	GO:0005372	water transmembrane transporter activity(GO:0005372)
0.0	0.1	GO:0031690	adrenergic receptor binding(GO:0031690)
0.0	0.1	GO:0071723	lipopeptide binding(GO:0071723)
0.0	0.1	GO:0043023	ribosomal large subunit binding(GO:0043023)
0.0	0.0	GO:0008142	oxysterol binding(GO:0008142)
0.0	0.0	GO:0034648	histone demethylase activity (H3-dimethyl-K4 specific)(GO:0034648)
0.0	0.0	GO:0070573	metallodipeptidase activity(GO:0070573)
0.0	0.0	GO:0050510	N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity(GO:0050510)
0.0	0.0	GO:0004367	glycerol-3-phosphate dehydrogenase [NAD+] activity(GO:0004367)
0.0	0.0	GO:0008184	glycogen phosphorylase activity(GO:0008184)
0.0	0.0	GO:0005148	prolactin receptor binding(GO:0005148)
0.0	0.0	GO:0050816	phosphothreonine binding(GO:0050816)
0.0	0.1	GO:0005432	calcium:sodium antiporter activity(GO:0005432)
0.0	0.2	GO:0070717	poly-purine tract binding(GO:0070717)
0.0	0.0	GO:0004920	interleukin-10 receptor activity(GO:0004920)
0.0	0.1	GO:0016832	aldehyde-lyase activity(GO:0016832)
0.0	0.3	GO:0017112	Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.0	0.0	GO:0000171	ribonuclease MRP activity(GO:0000171)
0.0	0.0	GO:0042296	ISG15 transferase activity(GO:0042296)
0.0	0.0	GO:0051434	BH3 domain binding(GO:0051434)
0.0	0.0	GO:0005131	growth hormone receptor binding(GO:0005131)
0.0	0.1	GO:0070095	fructose-6-phosphate binding(GO:0070095)
0.0	0.2	GO:0016641	oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor(GO:0016641)
0.0	0.2	GO:0043295	glutathione binding(GO:0043295) oligopeptide binding(GO:1900750)
0.0	0.5	GO:0050698	N-acetylglucosamine 6-O-sulfotransferase activity(GO:0001517) heparan sulfate 2-O-sulfotransferase activity(GO:0004394) HNK-1 sulfotransferase activity(GO:0016232) heparan sulfate 6-O-sulfotransferase activity(GO:0017095) trans-9R,10R-dihydrodiolphenanthrene sulfotransferase activity(GO:0018721) 1-phenanthrol sulfotransferase activity(GO:0018722) 3-phenanthrol sulfotransferase activity(GO:0018723) 4-phenanthrol sulfotransferase activity(GO:0018724) trans-3,4-dihydrodiolphenanthrene sulfotransferase activity(GO:0018725) 9-phenanthrol sulfotransferase activity(GO:0018726) 2-phenanthrol sulfotransferase activity(GO:0018727) phenanthrol sulfotransferase activity(GO:0019111) 1-hydroxypyrene sulfotransferase activity(GO:0034930) proteoglycan sulfotransferase activity(GO:0050698) cholesterol sulfotransferase activity(GO:0051922) hydroxyjasmonate sulfotransferase activity(GO:0080131)
0.0	0.0	GO:0019862	IgA binding(GO:0019862)
0.0	0.1	GO:0070300	phosphatidic acid binding(GO:0070300)
0.0	0.1	GO:0003836	beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.0	0.0	GO:0046404	ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity(GO:0046404) polydeoxyribonucleotide kinase activity(GO:0051733)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.6	PID VEGF VEGFR PATHWAY	VEGF and VEGFR signaling network
0.1	0.1	PID ERBB NETWORK PATHWAY	ErbB receptor signaling network
0.0	0.1	PID THROMBIN PAR1 PATHWAY	PAR1-mediated thrombin signaling events
0.0	2.2	PID MYC ACTIV PATHWAY	Validated targets of C-MYC transcriptional activation
0.0	1.0	PID INTEGRIN3 PATHWAY	Beta3 integrin cell surface interactions
0.0	0.2	PID TCR RAS PATHWAY	Ras signaling in the CD4+ TCR pathway
0.0	0.1	ST IL 13 PATHWAY	Interleukin 13 (IL-13) Pathway
0.0	0.0	ST WNT CA2 CYCLIC GMP PATHWAY	Wnt/Ca2+/cyclic GMP signaling.
0.0	0.9	PID RHOA REG PATHWAY	Regulation of RhoA activity
0.0	0.0	PID ECADHERIN NASCENT AJ PATHWAY	E-cadherin signaling in the nascent adherens junction
0.0	0.3	SA B CELL RECEPTOR COMPLEXES	Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.0	0.6	PID HNF3A PATHWAY	FOXA1 transcription factor network
0.0	0.1	PID TCPTP PATHWAY	Signaling events mediated by TCPTP
0.0	0.0	PID NECTIN PATHWAY	Nectin adhesion pathway
0.0	0.1	SA PROGRAMMED CELL DEATH	Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.0	0.1	PID ANGIOPOIETIN RECEPTOR PATHWAY	Angiopoietin receptor Tie2-mediated signaling
0.0	0.0	SIG IL4RECEPTOR IN B LYPHOCYTES	Genes related to IL4 rceptor signaling in B lymphocytes
0.0	0.2	ST GRANULE CELL SURVIVAL PATHWAY	Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway.
0.0	0.2	PID PTP1B PATHWAY	Signaling events mediated by PTP1B
0.0	0.6	PID MYC REPRESS PATHWAY	Validated targets of C-MYC transcriptional repression
0.0	0.2	PID DNA PK PATHWAY	DNA-PK pathway in nonhomologous end joining
0.0	0.3	PID IL12 STAT4 PATHWAY	IL12 signaling mediated by STAT4
0.0	0.0	PID HIV NEF PATHWAY	HIV-1 Nef: Negative effector of Fas and TNF-alpha
0.0	0.2	PID P38 MK2 PATHWAY	p38 signaling mediated by MAPKAP kinases

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.1	REACTOME PI3K EVENTS IN ERBB2 SIGNALING	Genes involved in PI3K events in ERBB2 signaling
0.1	0.1	REACTOME TRIGLYCERIDE BIOSYNTHESIS	Genes involved in Triglyceride Biosynthesis
0.1	0.6	REACTOME VEGF LIGAND RECEPTOR INTERACTIONS	Genes involved in VEGF ligand-receptor interactions
0.1	0.2	REACTOME OLFACTORY SIGNALING PATHWAY	Genes involved in Olfactory Signaling Pathway
0.1	0.8	REACTOME P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS	Genes involved in p130Cas linkage to MAPK signaling for integrins
0.0	1.0	REACTOME PRE NOTCH TRANSCRIPTION AND TRANSLATION	Genes involved in Pre-NOTCH Transcription and Translation
0.0	0.4	REACTOME INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1	Genes involved in Inhibition of replication initiation of damaged DNA by RB1/E2F1
0.0	0.4	REACTOME PROLACTIN RECEPTOR SIGNALING	Genes involved in Prolactin receptor signaling
0.0	0.6	REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT	Genes involved in Chylomicron-mediated lipid transport
0.0	0.8	REACTOME INSULIN RECEPTOR RECYCLING	Genes involved in Insulin receptor recycling
0.0	0.3	REACTOME TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING	Genes involved in TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
0.0	0.5	REACTOME OTHER SEMAPHORIN INTERACTIONS	Genes involved in Other semaphorin interactions
0.0	0.3	REACTOME METABOLISM OF PORPHYRINS	Genes involved in Metabolism of porphyrins
0.0	0.4	REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS	Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0	0.5	REACTOME SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE	Genes involved in Synthesis of PIPs at the Golgi membrane
0.0	0.3	REACTOME LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS	Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis
0.0	0.3	REACTOME GAP JUNCTION DEGRADATION	Genes involved in Gap junction degradation
0.0	0.6	REACTOME G1 PHASE	Genes involved in G1 Phase
0.0	0.2	REACTOME PECAM1 INTERACTIONS	Genes involved in PECAM1 interactions
0.0	0.2	REACTOME INTEGRATION OF PROVIRUS	Genes involved in Integration of provirus
0.0	0.1	REACTOME BINDING AND ENTRY OF HIV VIRION	Genes involved in Binding and entry of HIV virion
0.0	0.2	REACTOME RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES	Genes involved in Recruitment of NuMA to mitotic centrosomes
0.0	0.1	REACTOME XENOBIOTICS	Genes involved in Xenobiotics
0.0	0.1	REACTOME SOS MEDIATED SIGNALLING	Genes involved in SOS-mediated signalling
0.0	0.0	REACTOME SIGNALING BY FGFR	Genes involved in Signaling by FGFR
0.0	0.1	REACTOME RAF MAP KINASE CASCADE	Genes involved in RAF/MAP kinase cascade
0.0	0.2	REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING	Genes involved in Advanced glycosylation endproduct receptor signaling
0.0	0.3	REACTOME MYOGENESIS	Genes involved in Myogenesis
0.0	0.2	REACTOME ROLE OF DCC IN REGULATING APOPTOSIS	Genes involved in Role of DCC in regulating apoptosis
0.0	0.0	REACTOME SIGNALING BY SCF KIT	Genes involved in Signaling by SCF-KIT
0.0	0.1	REACTOME TRANSPORT OF ORGANIC ANIONS	Genes involved in Transport of organic anions
0.0	0.2	REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT	Genes involved in Organic cation/anion/zwitterion transport
0.0	0.3	REACTOME PEROXISOMAL LIPID METABOLISM	Genes involved in Peroxisomal lipid metabolism
0.0	0.2	REACTOME NUCLEAR EVENTS KINASE AND TRANSCRIPTION FACTOR ACTIVATION	Genes involved in Nuclear Events (kinase and transcription factor activation)
0.0	0.1	REACTOME BETA DEFENSINS	Genes involved in Beta defensins
0.0	0.0	REACTOME IL 7 SIGNALING	Genes involved in Interleukin-7 signaling
0.0	0.0	REACTOME GPVI MEDIATED ACTIVATION CASCADE	Genes involved in GPVI-mediated activation cascade
0.0	0.5	REACTOME INTERFERON GAMMA SIGNALING	Genes involved in Interferon gamma signaling
0.0	0.1	REACTOME CD28 DEPENDENT VAV1 PATHWAY	Genes involved in CD28 dependent Vav1 pathway
0.0	0.2	REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE	Genes involved in Sema4D induced cell migration and growth-cone collapse
0.0	0.3	REACTOME GLUTATHIONE CONJUGATION	Genes involved in Glutathione conjugation
0.0	0.1	REACTOME PASSIVE TRANSPORT BY AQUAPORINS	Genes involved in Passive Transport by Aquaporins
0.0	0.2	REACTOME CHOLESTEROL BIOSYNTHESIS	Genes involved in Cholesterol biosynthesis
0.0	0.1	REACTOME CREATION OF C4 AND C2 ACTIVATORS	Genes involved in Creation of C4 and C2 activators
0.0	0.0	REACTOME DIGESTION OF DIETARY CARBOHYDRATE	Genes involved in Digestion of dietary carbohydrate
0.0	0.1	REACTOME PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS	Genes involved in Presynaptic nicotinic acetylcholine receptors
0.0	0.2	REACTOME INSULIN SYNTHESIS AND PROCESSING	Genes involved in Insulin Synthesis and Processing
0.0	0.1	REACTOME NEPHRIN INTERACTIONS	Genes involved in Nephrin interactions
0.0	0.1	REACTOME REGULATION OF IFNA SIGNALING	Genes involved in Regulation of IFNA signaling
0.0	0.1	REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS	Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.0	0.0	REACTOME SHC RELATED EVENTS	Genes involved in SHC-related events

Results for Six3_Six1_Six2

Z-value: 1.41

Motif logo

Transcription factors associated with Six3_Six1_Six2

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

Activity of the Six3_Six1_Six2 motif across conditions

Conditions sorted by the z-value of the Six3_Six1_Six2 motif activity

Top target CREs of the motif:

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of Six3_Six1_Six2

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: