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ENCSR904DTN: DNase-seq of mouse liver in constant darkness

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Results for Six4

Z-value: 1.83

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Transcription factors associated with Six4

Gene Symbol	Gene ID	Gene Info
Six4 Ensembl NCBI MGI UniProt	ENSMUSG00000034460.8	sine oculis-related homeobox 4

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
chr12_73090801_73090962	Six4	22544	0.151942	0.88	2.0e-02	Click!
chr12_73091059_73091232	Six4	22280	0.152435	0.81	5.0e-02	Click!
chr12_73091277_73091487	Six4	22043	0.152874	-0.69	1.3e-01	Click!
chr12_73111618_73111769	Six4	1732	0.335350	0.20	7.0e-01	Click!

Activity of the Six4 motif across conditions

Conditions sorted by the z-value of the Six4 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr15_79347254_79347414	1.81	Maff	v-maf musculoaponeurotic fibrosarcoma oncogene family, protein F (avian)	186	0.9
chr2_132684569_132684730	1.61	Shld1	shieldin complex subunit 1	2282	0.18
chr12_109989506_109989657	1.38	Gm34667	predicted gene, 34667	34292	0.1
chr12_82855785_82855951	1.34	1700085C21Rik	RIKEN cDNA 1700085C21 gene	83287	0.09
chr3_83043842_83044694	1.27	Fgb	fibrinogen beta chain	5595	0.15
chr18_46336206_46336490	1.25	4930415P13Rik	RIKEN cDNA 4930415P13 gene	4081	0.17
chr4_99103188_99103384	1.20	Gm12852	predicted gene 12852	492	0.76
chr4_115610472_115610686	1.13	Cyp4a32	cytochrome P450, family 4, subfamily a, polypeptide 32	9604	0.13
chr2_77838834_77838985	1.11	Gm13661	predicted gene 13661	1707	0.38
chr6_113670024_113670201	1.10	Irak2	interleukin-1 receptor-associated kinase 2	334	0.72
chr1_192808464_192808629	1.07	Gm38360	predicted gene, 38360	12581	0.13
chr9_23030248_23030409	1.05	Bmper	BMP-binding endothelial regulator	192748	0.03
chr6_5498630_5498813	1.05	Pdk4	pyruvate dehydrogenase kinase, isoenzyme 4	2412	0.41
chr8_126586607_126587402	1.05	Irf2bp2	interferon regulatory factor 2 binding protein 2	6982	0.23
chr1_121297951_121298102	1.04	Gm38283	predicted gene, 38283	2805	0.24
chr10_24087275_24087474	1.03	Taar8b	trace amine-associated receptor 8B	4920	0.1
chr8_123736984_123737175	0.99	Gm45781	predicted gene 45781	1937	0.14
chr11_105944433_105944606	0.99	Cyb561	cytochrome b-561	32	0.93
chr6_145469440_145469652	0.96	Gm25373	predicted gene, 25373	5357	0.18
chr5_145999030_145999373	0.96	Cyp3a25	cytochrome P450, family 3, subfamily a, polypeptide 25	7558	0.13
chr19_36627452_36627789	0.95	Hectd2os	Hectd2, opposite strand	1596	0.43
chr10_118608506_118608657	0.93	Ifngas1	Ifng antisense RNA 1	52056	0.13
chr11_116083144_116083295	0.92	Wbp2	WW domain binding protein 2	1734	0.2
chr16_78427896_78428047	0.91	Gm25038	predicted gene, 25038	4112	0.21
chr10_127962398_127962784	0.90	Gm47949	predicted gene, 47949	1035	0.33
chr16_95709296_95709447	0.86	Ets2	E26 avian leukemia oncogene 2, 3' domain	3032	0.28
chr1_72835366_72835517	0.85	Igfbp2	insulin-like growth factor binding protein 2	10119	0.22
chr15_102181335_102181499	0.84	Csad	cysteine sulfinic acid decarboxylase	1556	0.24
chr12_102295217_102295408	0.84	Rin3	Ras and Rab interactor 3	11671	0.22
chr10_61418878_61419050	0.83	Nodal	nodal	992	0.4
chr2_126568384_126568535	0.82	Slc27a2	solute carrier family 27 (fatty acid transporter), member 2	3699	0.23
chr12_110866355_110866579	0.82	Mpc1-ps	mitochondrial pyruvate carrier 1, pseudogene	7573	0.09
chr19_4194138_4194289	0.81	Ppp1ca	protein phosphatase 1 catalytic subunit alpha	436	0.49
chr7_99062527_99062793	0.81	Gm33882	predicted gene, 33882	27572	0.14
chr11_60352559_60352715	0.81	Tom1l2	target of myb1-like 2 (chicken)	268	0.74
chr1_72833711_72833862	0.80	Igfbp2	insulin-like growth factor binding protein 2	8464	0.22
chr7_110060209_110060360	0.79	Zfp143	zinc finger protein 143	933	0.32
chr12_109988471_109988667	0.79	Gm34667	predicted gene, 34667	35304	0.09
chr17_12415417_12415751	0.78	Plg	plasminogen	36925	0.12
chr12_103856410_103857076	0.78	Serpina1a	serine (or cysteine) peptidase inhibitor, clade A, member 1A	6808	0.1
chr8_33881530_33881981	0.77	Gm26978	predicted gene, 26978	3992	0.21
chr14_66672460_66672626	0.76	Adra1a	adrenergic receptor, alpha 1a	36987	0.17
chr2_132134128_132134319	0.75	Gm14051	predicted gene 14051	10310	0.16
chr1_64791801_64792159	0.74	Plekhm3	pleckstrin homology domain containing, family M, member 3	44784	0.11
chr16_30023527_30023678	0.73	4632428C04Rik	RIKEN cDNA 4632428C04 gene	14935	0.14
chr17_14175138_14175307	0.73	Gm34510	predicted gene, 34510	28506	0.14
chr2_46365879_46366164	0.72	Gm13469	predicted gene 13469	40548	0.18
chr9_20862237_20862476	0.72	Shfl	shiftless antiviral inhibitor of ribosomal frameshifting	6286	0.09
chr10_93520708_93521069	0.71	Amdhd1	amidohydrolase domain containing 1	19145	0.12
chr11_106958781_106958936	0.71	Gm11707	predicted gene 11707	14232	0.13
chr10_71337816_71337971	0.71	Cisd1	CDGSH iron sulfur domain 1	7061	0.13
chr13_94250958_94251141	0.70	Scamp1	secretory carrier membrane protein 1	4491	0.2
chr7_145087928_145088130	0.70	Gm45181	predicted gene 45181	74967	0.09
chr11_44521626_44521777	0.70	Rnf145	ring finger protein 145	1396	0.4
chr4_35404302_35404465	0.69	Gm12368	predicted gene 12368	3325	0.31
chr2_154585580_154585751	0.68	E2f1	E2F transcription factor 1	15773	0.09
chr1_39192284_39192607	0.67	Npas2	neuronal PAS domain protein 2	1286	0.45
chr9_42751537_42751691	0.67	Grik4	glutamate receptor, ionotropic, kainate 4	57085	0.14
chr5_120516173_120516338	0.67	Slc8b1	solute carrier family 8 (sodium/lithium/calcium exchanger), member B1	3112	0.14
chr9_65331682_65331833	0.66	Gm39363	predicted gene, 39363	763	0.43
chr4_148602965_148603132	0.66	Masp2	mannan-binding lectin serine peptidase 2	473	0.67
chr8_11148675_11148826	0.65	Gm44717	predicted gene 44717	496	0.77
chr2_26342227_26342426	0.64	Gpsm1	G-protein signalling modulator 1 (AGS3-like, C. elegans)	37	0.94
chr1_184127436_184127603	0.64	Dusp10	dual specificity phosphatase 10	93138	0.08
chr11_20470031_20470186	0.63	Gm12034	predicted gene 12034	23696	0.2
chr4_155566693_155567032	0.63	Nadk	NAD kinase	2790	0.15
chr2_120518757_120518908	0.62	Zfp106	zinc finger protein 106	1714	0.3
chr6_128498495_128498880	0.62	Pzp	PZP, alpha-2-macroglobulin like	3464	0.12
chr5_52612417_52612612	0.62	8030423F21Rik	RIKEN cDNA 8030423F21 gene	6498	0.17
chr6_54726403_54726583	0.62	Gm44008	predicted gene, 44008	32847	0.14
chr9_95539522_95539698	0.61	Gm32281	predicted gene, 32281	14887	0.13
chr8_72221268_72221419	0.61	Fam32a	family with sequence similarity 32, member A	1579	0.21
chr1_176874134_176874434	0.61	Gm25993	predicted gene, 25993	5550	0.12
chr11_120624666_120624817	0.61	Mir6936	microRNA 6936	135	0.58
chr5_53437072_53437250	0.60	Gm26486	predicted gene, 26486	18588	0.17
chr3_88628445_88628599	0.59	Arhgef2	rho/rac guanine nucleotide exchange factor (GEF) 2	920	0.37
chr1_132791140_132791294	0.59	Gm22609	predicted gene, 22609	23131	0.17
chr4_99179862_99180013	0.59	Atg4c	autophagy related 4C, cysteine peptidase	13997	0.16
chr10_84054746_84054912	0.58	Gm37908	predicted gene, 37908	6929	0.2
chr5_145984724_145985158	0.58	Cyp3a25	cytochrome P450, family 3, subfamily a, polypeptide 25	6702	0.13
chr1_127419248_127419453	0.58	Gm38301	predicted gene, 38301	12574	0.21
chr8_36723231_36723557	0.58	Dlc1	deleted in liver cancer 1	9660	0.29
chr3_82952346_82952497	0.58	Gm30097	predicted gene, 30097	43164	0.1
chr4_138510025_138510190	0.58	Camk2n1	calcium/calmodulin-dependent protein kinase II inhibitor 1	55793	0.09
chr2_158225371_158225751	0.57	D630003M21Rik	RIKEN cDNA D630003M21 gene	3661	0.17
chr11_49244336_49244527	0.57	Mgat1	mannoside acetylglucosaminyltransferase 1	22	0.96
chr15_85706199_85706362	0.57	Mirlet7c-2	microRNA let7c-2	323	0.76
chr15_25942169_25942359	0.57	Retreg1	reticulophagy regulator 1	415	0.85
chr10_115779831_115780135	0.57	Tspan8	tetraspanin 8	36849	0.19
chr10_81557608_81557764	0.56	Tle5	TLE family member 5, transcriptional modulator	1802	0.15
chr8_46499865_46500163	0.56	Acsl1	acyl-CoA synthetase long-chain family member 1	7182	0.16
chr18_20594228_20594534	0.56	Dsg2	desmoglein 2	36135	0.13
chr12_40024025_40024204	0.56	Arl4a	ADP-ribosylation factor-like 4A	9630	0.19
chr6_90618862_90619013	0.56	Slc41a3	solute carrier family 41, member 3	210	0.92
chr2_73383782_73383933	0.55	Gpr155	G protein-coupled receptor 155	2541	0.17
chr1_136142734_136142885	0.55	Kif21b	kinesin family member 21B	11355	0.11
chr5_9056138_9056296	0.55	Gm40264	predicted gene, 40264	21093	0.14
chr6_129538595_129538908	0.55	Gm44243	predicted gene, 44243	1470	0.2
chr16_26163874_26164039	0.55	P3h2	prolyl 3-hydroxylase 2	58172	0.15
chr6_145352799_145353019	0.55	Gm23498	predicted gene, 23498	13949	0.13
chr17_28287629_28287780	0.55	Ppard	peroxisome proliferator activator receptor delta	5542	0.12
chr12_104850200_104850359	0.55	4930408O17Rik	RIKEN cDNA 4930408O17 gene	7092	0.19
chr10_118064905_118065056	0.54	5330439M10Rik	RIKEN cDNA 5330439M10 gene	47537	0.11
chr9_66330848_66331003	0.54	Herc1	HECT and RLD domain containing E3 ubiquitin protein ligase family member 1	19525	0.18
chr11_59973634_59973804	0.53	Pemt	phosphatidylethanolamine N-methyltransferase	2209	0.21
chr2_167655272_167655472	0.53	Gm20431	predicted gene 20431	6124	0.11
chr12_97061510_97061666	0.53	Gm47397	predicted gene, 47397	40876	0.21
chr4_149393453_149393614	0.53	Ube4b	ubiquitination factor E4B	5845	0.15
chr15_10799724_10800004	0.53	Gm19276	predicted gene, 19276	14928	0.22
chr2_145748022_145748197	0.53	Rin2	Ras and Rab interactor 2	36625	0.17
chr6_141680621_141680772	0.53	Slco1b2	solute carrier organic anion transporter family, member 1b2	550	0.84
chr3_40950656_40950819	0.52	Larp1b	La ribonucleoprotein domain family, member 1B	55	0.96
chr1_58144709_58145117	0.52	Gm24548	predicted gene, 24548	10175	0.19
chr9_48755281_48755902	0.52	Zbtb16	zinc finger and BTB domain containing 16	80354	0.09
chr7_127809790_127809985	0.51	Stx1b	syntaxin 1B	1037	0.26
chr12_83055714_83055884	0.51	Rgs6	regulator of G-protein signaling 6	8809	0.21
chr16_91362104_91362271	0.51	Ifnar2	interferon (alpha and beta) receptor 2	10596	0.11
chr4_35146445_35146642	0.51	Ifnk	interferon kappa	5513	0.2
chr15_74784537_74784692	0.51	Gm17189	predicted gene 17189	549	0.54
chr9_71165149_71165695	0.51	Aqp9	aquaporin 9	200	0.92
chr3_146570475_146570675	0.50	Uox	urate oxidase	149	0.94
chr16_29944225_29944722	0.50	Gm26569	predicted gene, 26569	2043	0.31
chr13_64398164_64398509	0.50	Ctsl	cathepsin L	27446	0.09
chr9_66251427_66251579	0.50	Dapk2	death-associated protein kinase 2	16871	0.22
chr16_97929638_97929799	0.50	C2cd2	C2 calcium-dependent domain containing 2	7085	0.18
chr17_47445492_47445785	0.49	1700001C19Rik	RIKEN cDNA 1700001C19 gene	8262	0.12
chr5_138076351_138076506	0.49	Zkscan1	zinc finger with KRAB and SCAN domains 1	8656	0.09
chr10_19910647_19910806	0.49	Pex7	peroxisomal biogenesis factor 7	3037	0.25
chr15_75965726_75965894	0.49	Eif2s3x-ps1	eukaryotic translation initiation factor 2, subunit 3, pseudogene 1	2525	0.11
chr12_91799117_91799273	0.49	Gm22015	predicted gene, 22015	7521	0.16
chr6_31137043_31137202	0.49	Gm13835	predicted gene 13835	5541	0.14
chr18_56451778_56452171	0.49	Gramd3	GRAM domain containing 3	17293	0.18
chr3_10059786_10059949	0.48	Gm9833	predicted gene 9833	28243	0.12
chr16_30259665_30259842	0.48	Gm49645	predicted gene, 49645	4601	0.16
chr10_127736977_127737152	0.48	Zbtb39	zinc finger and BTB domain containing 39	2474	0.13
chr13_28654991_28655297	0.48	Mir6368	microRNA 6368	55729	0.15
chr11_109505108_109505274	0.48	Gm22378	predicted gene, 22378	5367	0.15
chr2_104493347_104493515	0.48	Hipk3	homeodomain interacting protein kinase 3	259	0.9
chr9_57158250_57158427	0.48	Commd4	COMM domain containing 4	7	0.96
chr7_44820244_44820395	0.48	Nup62	nucleoporin 62	1882	0.14
chr10_99384294_99384806	0.48	B530045E10Rik	RIKEN cDNA B530045E10 gene	18240	0.17
chr15_25070046_25070197	0.48	Gm2824	predicted gene 2824	42763	0.15
chr11_105237702_105237861	0.48	Tlk2	tousled-like kinase 2 (Arabidopsis)	8977	0.19
chrX_12089989_12090141	0.48	Bcor	BCL6 interacting corepressor	9512	0.27
chrX_20829007_20829192	0.47	Gm24824	predicted gene, 24824	5285	0.12
chr6_134664500_134664832	0.47	Borcs5	BLOC-1 related complex subunit 5	23411	0.12
chr1_174466395_174466546	0.47	Olfr220	olfactory receptor 220	17845	0.16
chrX_140591289_140591485	0.46	AL683809.1	TSC22 domain family, member 3 (Tsc22d3), pseuodgene	7788	0.17
chr17_49349587_49349761	0.46	Gm18067	predicted gene, 18067	18178	0.18
chr5_139666621_139666772	0.46	Gm42424	predicted gene 42424	34951	0.13
chr5_113035586_113035983	0.46	Gm22740	predicted gene, 22740	8360	0.13
chr14_31022704_31022861	0.46	Pbrm1	polybromo 1	2725	0.12
chr8_123736768_123736919	0.46	Gm45781	predicted gene 45781	1701	0.16
chr12_54656909_54657087	0.46	Sptssa	serine palmitoyltransferase, small subunit A	425	0.63
chr10_85025946_85026098	0.46	Ric8b	RIC8 guanine nucleotide exchange factor B	17306	0.21
chr4_137764393_137764571	0.45	Alpl	alkaline phosphatase, liver/bone/kidney	1993	0.33
chr18_35676274_35676439	0.45	Dnajc18	DnaJ heat shock protein family (Hsp40) member C18	10387	0.08
chr3_38937309_38937496	0.45	Fat4	FAT atypical cadherin 4	46460	0.15
chr2_84773408_84773586	0.45	Serping1	serine (or cysteine) peptidase inhibitor, clade G, member 1	1631	0.21
chr12_33302961_33303147	0.45	Atxn7l1	ataxin 7-like 1	539	0.8
chr10_80273995_80274206	0.45	Mir6911	microRNA 6911	4064	0.08
chr16_91820333_91820502	0.45	Itsn1	intersectin 1 (SH3 domain protein 1A)	3591	0.23
chr8_94214034_94214210	0.44	Nup93	nucleoporin 93	442	0.72
chr6_121159588_121159765	0.44	Pex26	peroxisomal biogenesis factor 26	23991	0.12
chr16_35919055_35919394	0.44	Gm10237	predicted gene 10237	1240	0.32
chr2_163411853_163412159	0.44	Oser1	oxidative stress responsive serine rich 1	341	0.82
chr11_116199230_116199400	0.43	Acox1	acyl-Coenzyme A oxidase 1, palmitoyl	270	0.54
chr6_128482799_128482997	0.43	Pzp	PZP, alpha-2-macroglobulin like	4957	0.1
chr6_143482695_143483407	0.43	Gm23272	predicted gene, 23272	17654	0.24
chr5_129895959_129896119	0.43	Zbed5	zinc finger, BED type containing 5	261	0.82
chr5_32092059_32092277	0.43	Babam2	BRISC and BRCA1 A complex member 2	12471	0.17
chr11_108222744_108222895	0.43	Gm11655	predicted gene 11655	40969	0.17
chr3_149188820_149188981	0.43	Gm42647	predicted gene 42647	21371	0.2
chr6_91104887_91105054	0.43	Nup210	nucleoporin 210	6348	0.17
chr14_25511941_25512115	0.43	Zmiz1	zinc finger, MIZ-type containing 1	9373	0.15
chr8_21776372_21776703	0.43	Defb1	defensin beta 1	62	0.95
chr14_73357414_73357565	0.43	Itm2b	integral membrane protein 2B	11016	0.18
chr9_65467758_65467928	0.43	Spg21	SPG21, maspardin	946	0.42
chr2_36082178_36082681	0.43	Lhx6	LIM homeobox protein 6	11844	0.12
chr8_46323996_46324157	0.42	Gm45255	predicted gene 45255	10275	0.12
chr19_40661223_40661381	0.42	Entpd1	ectonucleoside triphosphate diphosphohydrolase 1	809	0.55
chr5_38560875_38561037	0.42	Wdr1	WD repeat domain 1	587	0.71
chr2_70663831_70664043	0.42	Gorasp2	golgi reassembly stacking protein 2	1737	0.28
chr6_125082928_125083092	0.42	2010008C14Rik	RIKEN cDNA 2010008C14 gene	427	0.62
chr7_127807539_127807744	0.42	Stx1b	syntaxin 1B	3283	0.09
chr10_63373272_63373423	0.42	Sirt1	sirtuin 1	8357	0.13
chr8_12842687_12842838	0.42	Atp11a	ATPase, class VI, type 11A	5093	0.14
chr13_51644627_51644994	0.42	Cks2	CDC28 protein kinase regulatory subunit 2	422	0.8
chr5_140159110_140159261	0.42	Gm43195	predicted gene 43195	7698	0.17
chr5_121696090_121696243	0.42	Brap	BRCA1 associated protein	13238	0.1
chr17_56406325_56406483	0.42	Ptprs	protein tyrosine phosphatase, receptor type, S	8026	0.14
chr7_80635100_80635316	0.42	Gm15880	predicted gene 15880	809	0.58
chr14_86309035_86309286	0.42	Gm23926	predicted gene, 23926	2218	0.22
chr11_3984447_3984636	0.42	Gal3st1	galactose-3-O-sulfotransferase 1	828	0.43
chr6_17172773_17172927	0.42	Gm4876	predicted gene 4876	1017	0.58
chrX_96239776_96239927	0.42	F630028O10Rik	RIKEN cDNA F630028O10 gene	75	0.96
chr1_87032318_87032489	0.41	Gm37447	predicted gene, 37447	4320	0.14
chr10_17518558_17518732	0.41	Gm47769	predicted gene, 47769	1963	0.31
chr15_10983328_10983499	0.41	Amacr	alpha-methylacyl-CoA racemase	7	0.97
chr7_45261613_45261778	0.41	Slc6a16	solute carrier family 6, member 16	2664	0.1

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of Six4

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	0.6	GO:0060137	maternal process involved in parturition(GO:0060137)
0.2	0.8	GO:0006548	histidine catabolic process(GO:0006548) imidazole-containing compound catabolic process(GO:0052805)
0.1	0.4	GO:0043152	induction of bacterial agglutination(GO:0043152)
0.1	0.5	GO:0051365	cellular response to potassium ion starvation(GO:0051365)
0.1	0.5	GO:0010510	regulation of acetyl-CoA biosynthetic process from pyruvate(GO:0010510)
0.1	0.5	GO:0071442	positive regulation of histone H3-K14 acetylation(GO:0071442)
0.1	0.3	GO:0061092	regulation of phospholipid translocation(GO:0061091) positive regulation of phospholipid translocation(GO:0061092)
0.1	0.5	GO:0071918	urea transmembrane transport(GO:0071918)
0.1	0.3	GO:0019448	cysteine catabolic process(GO:0009093) L-cysteine catabolic process(GO:0019448) L-cysteine metabolic process(GO:0046439)
0.1	0.3	GO:2001170	negative regulation of ATP biosynthetic process(GO:2001170)
0.1	0.4	GO:0071225	cellular response to muramyl dipeptide(GO:0071225)
0.1	0.3	GO:0065001	specification of axis polarity(GO:0065001)
0.1	0.2	GO:0006556	S-adenosylmethionine biosynthetic process(GO:0006556)
0.1	0.2	GO:0010911	regulation of isomerase activity(GO:0010911) positive regulation of isomerase activity(GO:0010912)
0.1	0.2	GO:1901475	pyruvate transmembrane transport(GO:1901475)
0.1	0.2	GO:0035022	positive regulation of Rac protein signal transduction(GO:0035022)
0.1	0.1	GO:0035860	glial cell-derived neurotrophic factor receptor signaling pathway(GO:0035860)
0.1	0.1	GO:2001274	negative regulation of glucose import in response to insulin stimulus(GO:2001274)
0.1	0.4	GO:0035426	extracellular matrix-cell signaling(GO:0035426)
0.1	0.3	GO:0001712	ectodermal cell fate commitment(GO:0001712)
0.1	0.2	GO:0032474	otolith morphogenesis(GO:0032474)
0.1	0.3	GO:0060264	regulation of respiratory burst involved in inflammatory response(GO:0060264)
0.1	0.1	GO:0045726	positive regulation of integrin biosynthetic process(GO:0045726)
0.1	0.2	GO:0045897	regulation of transcription during mitosis(GO:0045896) positive regulation of transcription during mitosis(GO:0045897)
0.1	0.6	GO:0001867	complement activation, lectin pathway(GO:0001867)
0.1	0.5	GO:0005981	regulation of glycogen catabolic process(GO:0005981)
0.1	0.2	GO:2000418	positive regulation of eosinophil migration(GO:2000418)
0.1	0.3	GO:0032876	negative regulation of DNA endoreduplication(GO:0032876)
0.1	0.1	GO:0048320	axial mesoderm formation(GO:0048320)
0.1	0.2	GO:0072061	inner medullary collecting duct development(GO:0072061)
0.1	0.2	GO:0014734	skeletal muscle hypertrophy(GO:0014734)
0.1	0.2	GO:0006681	galactosylceramide metabolic process(GO:0006681)
0.1	0.2	GO:1904528	regulation of microtubule binding(GO:1904526) positive regulation of microtubule binding(GO:1904528)
0.1	0.3	GO:0045053	protein retention in Golgi apparatus(GO:0045053)
0.1	0.2	GO:0072675	osteoclast fusion(GO:0072675)
0.1	0.2	GO:0021914	negative regulation of smoothened signaling pathway involved in ventral spinal cord patterning(GO:0021914)
0.1	0.2	GO:0021555	midbrain-hindbrain boundary morphogenesis(GO:0021555)
0.1	0.3	GO:0034638	phosphatidylcholine catabolic process(GO:0034638)
0.1	0.2	GO:0030423	targeting of mRNA for destruction involved in RNA interference(GO:0030423)
0.1	0.2	GO:0032910	transforming growth factor beta3 production(GO:0032907) regulation of transforming growth factor beta3 production(GO:0032910)
0.1	0.2	GO:1903279	regulation of calcium:sodium antiporter activity(GO:1903279)
0.1	0.2	GO:1904217	regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity(GO:1904217) positive regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity(GO:1904219) regulation of serine C-palmitoyltransferase activity(GO:1904220) positive regulation of serine C-palmitoyltransferase activity(GO:1904222)
0.0	0.1	GO:0014858	positive regulation of skeletal muscle cell proliferation(GO:0014858)
0.0	0.2	GO:0098814	spontaneous neurotransmitter secretion(GO:0061669) spontaneous synaptic transmission(GO:0098814)
0.0	0.2	GO:0007023	post-chaperonin tubulin folding pathway(GO:0007023)
0.0	0.1	GO:1903999	negative regulation of eating behavior(GO:1903999)
0.0	0.7	GO:0007250	activation of NF-kappaB-inducing kinase activity(GO:0007250)
0.0	0.1	GO:0001996	positive regulation of heart rate by epinephrine-norepinephrine(GO:0001996)
0.0	0.0	GO:0060268	negative regulation of respiratory burst(GO:0060268)
0.0	0.2	GO:0046813	receptor-mediated virion attachment to host cell(GO:0046813)
0.0	0.3	GO:0060136	embryonic process involved in female pregnancy(GO:0060136)
0.0	0.1	GO:0021564	vagus nerve development(GO:0021564)
0.0	0.1	GO:0001560	regulation of cell growth by extracellular stimulus(GO:0001560)
0.0	0.1	GO:0097384	ether lipid biosynthetic process(GO:0008611) glycerol ether biosynthetic process(GO:0046504) cellular lipid biosynthetic process(GO:0097384) ether biosynthetic process(GO:1901503)
0.0	0.1	GO:2000670	positive regulation of dendritic cell apoptotic process(GO:2000670)
0.0	0.1	GO:0071879	positive regulation of adrenergic receptor signaling pathway(GO:0071879)
0.0	0.1	GO:1901321	positive regulation of heart induction(GO:1901321)
0.0	0.2	GO:0006528	asparagine metabolic process(GO:0006528)
0.0	0.2	GO:0070314	G1 to G0 transition(GO:0070314)
0.0	1.7	GO:0045604	regulation of epidermal cell differentiation(GO:0045604)
0.0	0.4	GO:0043508	negative regulation of JUN kinase activity(GO:0043508)
0.0	0.1	GO:0072378	blood coagulation, fibrin clot formation(GO:0072378)
0.0	0.1	GO:0002432	granuloma formation(GO:0002432)
0.0	0.2	GO:0061002	negative regulation of dendritic spine morphogenesis(GO:0061002)
0.0	0.1	GO:2000767	positive regulation of cytoplasmic translation(GO:2000767)
0.0	0.2	GO:0034144	negative regulation of toll-like receptor 4 signaling pathway(GO:0034144)
0.0	0.2	GO:0071374	cellular response to parathyroid hormone stimulus(GO:0071374)
0.0	0.1	GO:0038044	transforming growth factor-beta secretion(GO:0038044) regulation of transforming growth factor-beta secretion(GO:2001201)
0.0	0.1	GO:0046208	spermine catabolic process(GO:0046208)
0.0	0.1	GO:0036015	response to interleukin-3(GO:0036015) cellular response to interleukin-3(GO:0036016)
0.0	0.1	GO:0035521	monoubiquitinated histone deubiquitination(GO:0035521) monoubiquitinated histone H2A deubiquitination(GO:0035522)
0.0	0.1	GO:0072361	regulation of glycolytic process by regulation of transcription from RNA polymerase II promoter(GO:0072361)
0.0	0.4	GO:0006047	UDP-N-acetylglucosamine metabolic process(GO:0006047)
0.0	0.1	GO:0051534	negative regulation of NFAT protein import into nucleus(GO:0051534)
0.0	0.1	GO:0018879	biphenyl metabolic process(GO:0018879)
0.0	0.1	GO:1903898	negative regulation of PERK-mediated unfolded protein response(GO:1903898)
0.0	0.1	GO:0006113	fermentation(GO:0006113) glucose catabolic process to lactate(GO:0019659) glycolytic fermentation(GO:0019660) glucose catabolic process to lactate via pyruvate(GO:0019661)
0.0	0.2	GO:0061302	smooth muscle cell-matrix adhesion(GO:0061302)
0.0	0.1	GO:0072197	ureter morphogenesis(GO:0072197)
0.0	0.4	GO:0002076	osteoblast development(GO:0002076)
0.0	0.1	GO:1903553	positive regulation of extracellular exosome assembly(GO:1903553)
0.0	0.1	GO:0071727	response to triacyl bacterial lipopeptide(GO:0071725) cellular response to triacyl bacterial lipopeptide(GO:0071727)
0.0	0.1	GO:0002314	germinal center B cell differentiation(GO:0002314)
0.0	0.1	GO:1901492	positive regulation of lymphangiogenesis(GO:1901492)
0.0	0.0	GO:0003199	endocardial cushion to mesenchymal transition involved in heart valve formation(GO:0003199)
0.0	0.2	GO:0001561	fatty acid alpha-oxidation(GO:0001561)
0.0	0.2	GO:0009115	xanthine catabolic process(GO:0009115)
0.0	0.1	GO:0051697	protein delipidation(GO:0051697)
0.0	0.2	GO:0051775	response to redox state(GO:0051775)
0.0	0.1	GO:0035441	cell migration involved in vasculogenesis(GO:0035441)
0.0	0.1	GO:0031508	pericentric heterochromatin assembly(GO:0031508)
0.0	0.1	GO:0031443	fast-twitch skeletal muscle fiber contraction(GO:0031443)
0.0	0.1	GO:1901382	chorionic trophoblast cell proliferation(GO:0097360) regulation of chorionic trophoblast cell proliferation(GO:1901382)
0.0	0.1	GO:0060397	JAK-STAT cascade involved in growth hormone signaling pathway(GO:0060397)
0.0	0.1	GO:0006432	phenylalanyl-tRNA aminoacylation(GO:0006432)
0.0	0.1	GO:0070574	cadmium ion transport(GO:0015691) cadmium ion transmembrane transport(GO:0070574)
0.0	0.1	GO:0006216	cytidine catabolic process(GO:0006216) cytidine deamination(GO:0009972) cytidine metabolic process(GO:0046087)
0.0	0.2	GO:0051639	actin filament network formation(GO:0051639)
0.0	0.1	GO:0051611	negative regulation of neurotransmitter uptake(GO:0051581) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612)
0.0	0.1	GO:0051964	negative regulation of synapse assembly(GO:0051964)
0.0	0.1	GO:0071930	negative regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0071930)
0.0	0.1	GO:2000973	regulation of pro-B cell differentiation(GO:2000973)
0.0	0.3	GO:0016559	peroxisome fission(GO:0016559)
0.0	0.3	GO:0008300	isoprenoid catabolic process(GO:0008300)
0.0	0.1	GO:0070295	renal water absorption(GO:0070295)
0.0	0.1	GO:2000491	positive regulation of hepatic stellate cell activation(GO:2000491)
0.0	0.2	GO:0006776	vitamin A metabolic process(GO:0006776)
0.0	0.1	GO:0060948	cardiac vascular smooth muscle cell development(GO:0060948)
0.0	0.1	GO:0043490	malate-aspartate shuttle(GO:0043490)
0.0	0.1	GO:0097680	double-strand break repair via classical nonhomologous end joining(GO:0097680)
0.0	0.3	GO:0032000	positive regulation of fatty acid beta-oxidation(GO:0032000)
0.0	0.1	GO:0032439	endosome localization(GO:0032439)
0.0	0.3	GO:0051292	nuclear pore complex assembly(GO:0051292)
0.0	0.2	GO:0043653	mitochondrial fragmentation involved in apoptotic process(GO:0043653)
0.0	0.1	GO:0006177	GMP biosynthetic process(GO:0006177)
0.0	0.1	GO:0006741	NADP biosynthetic process(GO:0006741)
0.0	0.1	GO:0045200	establishment or maintenance of neuroblast polarity(GO:0045196) establishment of neuroblast polarity(GO:0045200)
0.0	0.1	GO:2000587	regulation of platelet-derived growth factor receptor-beta signaling pathway(GO:2000586) negative regulation of platelet-derived growth factor receptor-beta signaling pathway(GO:2000587)
0.0	0.2	GO:0046415	urate metabolic process(GO:0046415)
0.0	0.1	GO:0035526	retrograde transport, plasma membrane to Golgi(GO:0035526)
0.0	0.1	GO:0061087	positive regulation of histone H3-K27 methylation(GO:0061087)
0.0	0.1	GO:0006547	histidine metabolic process(GO:0006547)
0.0	0.1	GO:0038161	prolactin signaling pathway(GO:0038161)
0.0	0.0	GO:1901069	guanosine-containing compound catabolic process(GO:1901069)
0.0	0.1	GO:0090526	regulation of gluconeogenesis involved in cellular glucose homeostasis(GO:0090526)
0.0	0.1	GO:0033387	putrescine biosynthetic process from ornithine(GO:0033387)
0.0	0.2	GO:0046321	positive regulation of fatty acid oxidation(GO:0046321)
0.0	0.1	GO:0046499	S-adenosylmethioninamine metabolic process(GO:0046499)
0.0	0.0	GO:0036493	positive regulation of translation in response to endoplasmic reticulum stress(GO:0036493)
0.0	0.2	GO:0010216	maintenance of DNA methylation(GO:0010216)
0.0	0.1	GO:0060605	tube lumen cavitation(GO:0060605) salivary gland cavitation(GO:0060662)
0.0	0.1	GO:1902744	negative regulation of lamellipodium organization(GO:1902744)
0.0	0.1	GO:0007084	mitotic nuclear envelope reassembly(GO:0007084)
0.0	0.2	GO:0006620	posttranslational protein targeting to membrane(GO:0006620)
0.0	0.1	GO:0010727	negative regulation of hydrogen peroxide metabolic process(GO:0010727)
0.0	0.2	GO:0035999	tetrahydrofolate interconversion(GO:0035999)
0.0	0.2	GO:0061000	negative regulation of dendritic spine development(GO:0061000)
0.0	0.1	GO:0021698	cerebellar cortex structural organization(GO:0021698)
0.0	0.1	GO:0071286	cellular response to magnesium ion(GO:0071286)
0.0	0.1	GO:0006686	sphingomyelin biosynthetic process(GO:0006686)
0.0	0.4	GO:0015721	bile acid and bile salt transport(GO:0015721)
0.0	0.1	GO:0034983	peptidyl-lysine deacetylation(GO:0034983)
0.0	0.1	GO:0060059	embryonic retina morphogenesis in camera-type eye(GO:0060059)
0.0	0.1	GO:1901165	positive regulation of trophoblast cell migration(GO:1901165)
0.0	0.2	GO:1902285	semaphorin-plexin signaling pathway involved in neuron projection guidance(GO:1902285)
0.0	0.1	GO:0006362	transcription elongation from RNA polymerase I promoter(GO:0006362)
0.0	0.0	GO:0030917	midbrain-hindbrain boundary development(GO:0030917)
0.0	0.1	GO:0051182	coenzyme transport(GO:0051182)
0.0	0.0	GO:0006189	'de novo' IMP biosynthetic process(GO:0006189)
0.0	0.5	GO:0043567	regulation of insulin-like growth factor receptor signaling pathway(GO:0043567)
0.0	0.0	GO:0046136	positive regulation of vitamin metabolic process(GO:0046136) positive regulation of vitamin D biosynthetic process(GO:0060557) positive regulation of calcidiol 1-monooxygenase activity(GO:0060559)
0.0	0.1	GO:0031946	regulation of glucocorticoid biosynthetic process(GO:0031946)
0.0	0.1	GO:1902990	mitotic telomere maintenance via semi-conservative replication(GO:1902990)
0.0	0.1	GO:0070561	vitamin D receptor signaling pathway(GO:0070561)
0.0	0.1	GO:0072137	condensed mesenchymal cell proliferation(GO:0072137)
0.0	0.1	GO:0072282	metanephric nephron tubule morphogenesis(GO:0072282)
0.0	0.1	GO:0009786	regulation of asymmetric cell division(GO:0009786)
0.0	0.1	GO:0006646	phosphatidylethanolamine biosynthetic process(GO:0006646)
0.0	0.1	GO:0043974	histone H3-K27 acetylation(GO:0043974) regulation of histone H3-K27 acetylation(GO:1901674)
0.0	0.3	GO:0051974	negative regulation of telomerase activity(GO:0051974)
0.0	0.1	GO:0019626	short-chain fatty acid catabolic process(GO:0019626)
0.0	0.2	GO:0032836	glomerular basement membrane development(GO:0032836)
0.0	0.1	GO:1904707	positive regulation of vascular smooth muscle cell proliferation(GO:1904707)
0.0	0.1	GO:0070358	actin polymerization-dependent cell motility(GO:0070358)
0.0	0.1	GO:0046135	pyrimidine nucleoside catabolic process(GO:0046135)
0.0	0.0	GO:0010693	negative regulation of alkaline phosphatase activity(GO:0010693)
0.0	0.0	GO:0006868	glutamine transport(GO:0006868)
0.0	0.3	GO:0006144	purine nucleobase metabolic process(GO:0006144)
0.0	0.0	GO:1901844	regulation of cell communication by electrical coupling involved in cardiac conduction(GO:1901844)
0.0	0.1	GO:0075509	receptor-mediated endocytosis of virus by host cell(GO:0019065) endocytosis involved in viral entry into host cell(GO:0075509)
0.0	0.1	GO:2000705	regulation of dense core granule biogenesis(GO:2000705)
0.0	0.1	GO:0032211	negative regulation of telomere maintenance via telomerase(GO:0032211)
0.0	0.2	GO:0010898	positive regulation of triglyceride catabolic process(GO:0010898)
0.0	0.0	GO:1904747	apoptotic process involved in mammary gland involution(GO:0060057) positive regulation of apoptotic process involved in mammary gland involution(GO:0060058) positive regulation of apoptotic process involved in morphogenesis(GO:1902339) regulation of mammary gland involution(GO:1903519) positive regulation of mammary gland involution(GO:1903521) positive regulation of apoptotic process involved in development(GO:1904747)
0.0	0.1	GO:0035630	bone mineralization involved in bone maturation(GO:0035630)
0.0	0.1	GO:0032929	negative regulation of superoxide anion generation(GO:0032929)
0.0	0.0	GO:0035963	response to interleukin-13(GO:0035962) cellular response to interleukin-13(GO:0035963)
0.0	0.0	GO:0006344	maintenance of chromatin silencing(GO:0006344)
0.0	0.0	GO:0046337	phosphatidylethanolamine metabolic process(GO:0046337)
0.0	0.1	GO:0070837	dehydroascorbic acid transport(GO:0070837)
0.0	0.1	GO:0030242	pexophagy(GO:0030242)
0.0	0.0	GO:0070889	platelet alpha granule organization(GO:0070889)
0.0	0.2	GO:0016338	calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338)
0.0	0.1	GO:0048702	embryonic neurocranium morphogenesis(GO:0048702)
0.0	0.0	GO:0051902	negative regulation of mitochondrial depolarization(GO:0051902)
0.0	0.1	GO:0070649	formin-nucleated actin cable assembly(GO:0070649)
0.0	0.1	GO:0007296	vitellogenesis(GO:0007296)
0.0	0.1	GO:0052405	negative regulation by host of symbiont molecular function(GO:0052405) modification by host of symbiont molecular function(GO:0052428)
0.0	0.2	GO:1901339	regulation of store-operated calcium channel activity(GO:1901339)
0.0	0.1	GO:2000564	regulation of CD8-positive, alpha-beta T cell proliferation(GO:2000564)
0.0	0.0	GO:1903232	melanosome assembly(GO:1903232)
0.0	0.3	GO:0046597	negative regulation of viral entry into host cell(GO:0046597)
0.0	0.1	GO:1900029	positive regulation of ruffle assembly(GO:1900029)
0.0	0.3	GO:0099625	regulation of ventricular cardiac muscle cell membrane repolarization(GO:0060307) ventricular cardiac muscle cell membrane repolarization(GO:0099625)
0.0	0.1	GO:0048387	negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.0	0.0	GO:2000138	positive regulation of cell proliferation involved in heart morphogenesis(GO:2000138)
0.0	0.1	GO:0015705	iodide transport(GO:0015705)
0.0	0.2	GO:0030953	astral microtubule organization(GO:0030953)
0.0	0.0	GO:2000416	regulation of eosinophil migration(GO:2000416)
0.0	0.1	GO:0050689	negative regulation of defense response to virus by host(GO:0050689)
0.0	0.2	GO:0070633	transepithelial transport(GO:0070633)
0.0	0.1	GO:0060729	intestinal epithelial structure maintenance(GO:0060729)
0.0	0.1	GO:0048671	negative regulation of collateral sprouting(GO:0048671)
0.0	0.0	GO:0021559	trigeminal nerve development(GO:0021559)
0.0	0.1	GO:0036438	maintenance of lens transparency(GO:0036438)
0.0	0.1	GO:0010991	negative regulation of SMAD protein complex assembly(GO:0010991)
0.0	0.1	GO:0043173	nucleotide salvage(GO:0043173)
0.0	0.1	GO:0046341	CDP-diacylglycerol metabolic process(GO:0046341)
0.0	0.1	GO:0070431	nucleotide-binding oligomerization domain containing signaling pathway(GO:0070423) nucleotide-binding oligomerization domain containing 2 signaling pathway(GO:0070431)
0.0	0.0	GO:0015744	succinate transport(GO:0015744)
0.0	0.0	GO:0060018	astrocyte fate commitment(GO:0060018)
0.0	0.1	GO:1903237	negative regulation of leukocyte tethering or rolling(GO:1903237)
0.0	0.1	GO:2000173	negative regulation of branching morphogenesis of a nerve(GO:2000173)
0.0	0.0	GO:0032875	regulation of DNA endoreduplication(GO:0032875)
0.0	0.0	GO:0006933	negative regulation of cell adhesion involved in substrate-bound cell migration(GO:0006933)
0.0	0.2	GO:0002467	germinal center formation(GO:0002467)
0.0	0.1	GO:0001672	regulation of chromatin assembly or disassembly(GO:0001672)
0.0	0.1	GO:0033499	galactose catabolic process via UDP-galactose(GO:0033499) glycolytic process from galactose(GO:0061623)
0.0	0.1	GO:0070213	protein auto-ADP-ribosylation(GO:0070213)
0.0	0.0	GO:0033088	negative regulation of immature T cell proliferation in thymus(GO:0033088)
0.0	0.1	GO:0042637	catagen(GO:0042637)
0.0	0.1	GO:0044341	sodium-dependent phosphate transport(GO:0044341)
0.0	0.1	GO:0003198	epithelial to mesenchymal transition involved in endocardial cushion formation(GO:0003198)
0.0	0.1	GO:0001842	neural fold formation(GO:0001842)
0.0	0.0	GO:0030886	negative regulation of myeloid dendritic cell activation(GO:0030886)
0.0	0.1	GO:0061450	trophoblast cell migration(GO:0061450)
0.0	0.4	GO:0034340	response to type I interferon(GO:0034340)
0.0	0.0	GO:1990314	cellular response to insulin-like growth factor stimulus(GO:1990314)
0.0	0.1	GO:0006768	biotin metabolic process(GO:0006768)
0.0	0.1	GO:0031507	heterochromatin assembly(GO:0031507)
0.0	0.1	GO:0002074	extraocular skeletal muscle development(GO:0002074)
0.0	0.2	GO:0045682	regulation of epidermis development(GO:0045682)
0.0	0.1	GO:0000185	activation of MAPKKK activity(GO:0000185)
0.0	0.1	GO:0030647	polyketide metabolic process(GO:0030638) aminoglycoside antibiotic metabolic process(GO:0030647) daunorubicin metabolic process(GO:0044597) doxorubicin metabolic process(GO:0044598)
0.0	0.1	GO:0051031	tRNA transport(GO:0051031)
0.0	0.0	GO:0021937	cerebellar Purkinje cell-granule cell precursor cell signaling involved in regulation of granule cell precursor cell proliferation(GO:0021937)
0.0	0.2	GO:0097094	craniofacial suture morphogenesis(GO:0097094)
0.0	0.1	GO:0019368	fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.0	0.1	GO:0051790	short-chain fatty acid biosynthetic process(GO:0051790)
0.0	0.0	GO:0097118	neuroligin clustering involved in postsynaptic membrane assembly(GO:0097118)
0.0	0.0	GO:0030997	regulation of centriole-centriole cohesion(GO:0030997)
0.0	0.1	GO:0032328	alanine transport(GO:0032328)
0.0	0.0	GO:0035509	negative regulation of myosin-light-chain-phosphatase activity(GO:0035509)
0.0	0.0	GO:0035771	interleukin-4-mediated signaling pathway(GO:0035771)
0.0	0.1	GO:0002677	negative regulation of chronic inflammatory response(GO:0002677)
0.0	0.0	GO:0032831	positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation(GO:0032831)
0.0	0.7	GO:0007566	embryo implantation(GO:0007566)
0.0	0.1	GO:1902166	negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator(GO:1902166)
0.0	0.0	GO:0010536	positive regulation of activation of Janus kinase activity(GO:0010536)
0.0	0.2	GO:0045603	positive regulation of endothelial cell differentiation(GO:0045603)
0.0	0.1	GO:0051387	negative regulation of neurotrophin TRK receptor signaling pathway(GO:0051387)
0.0	0.1	GO:1900122	positive regulation of receptor binding(GO:1900122)
0.0	0.1	GO:0006689	ganglioside catabolic process(GO:0006689)
0.0	0.1	GO:0034214	protein hexamerization(GO:0034214)
0.0	0.2	GO:2000310	regulation of N-methyl-D-aspartate selective glutamate receptor activity(GO:2000310)
0.0	0.0	GO:0043415	positive regulation of skeletal muscle tissue regeneration(GO:0043415)
0.0	0.4	GO:0001913	T cell mediated cytotoxicity(GO:0001913)
0.0	0.0	GO:0061535	glutamate secretion, neurotransmission(GO:0061535)
0.0	0.0	GO:0034476	U1 snRNA 3'-end processing(GO:0034473) U5 snRNA 3'-end processing(GO:0034476)
0.0	0.1	GO:0030222	eosinophil differentiation(GO:0030222)
0.0	0.1	GO:0090557	establishment of endothelial intestinal barrier(GO:0090557)
0.0	0.0	GO:0006624	vacuolar protein processing(GO:0006624)
0.0	0.0	GO:0043518	negative regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043518)
0.0	0.1	GO:0006851	mitochondrial calcium ion transport(GO:0006851)
0.0	0.1	GO:0006651	diacylglycerol biosynthetic process(GO:0006651)
0.0	0.0	GO:1903116	positive regulation of actin filament-based movement(GO:1903116)
0.0	0.0	GO:0070827	chromatin maintenance(GO:0070827)
0.0	0.1	GO:0007217	tachykinin receptor signaling pathway(GO:0007217)
0.0	0.0	GO:0014012	peripheral nervous system axon regeneration(GO:0014012)
0.0	0.0	GO:0060762	regulation of branching involved in mammary gland duct morphogenesis(GO:0060762)
0.0	0.0	GO:2000503	positive regulation of natural killer cell chemotaxis(GO:2000503)
0.0	0.1	GO:2000010	positive regulation of protein localization to cell surface(GO:2000010)
0.0	0.0	GO:0048133	germ-line stem cell division(GO:0042078) male germ-line stem cell asymmetric division(GO:0048133) germline stem cell asymmetric division(GO:0098728)
0.0	0.2	GO:0050860	negative regulation of T cell receptor signaling pathway(GO:0050860)
0.0	0.1	GO:0070327	thyroid hormone transport(GO:0070327)
0.0	0.0	GO:0019086	late viral transcription(GO:0019086)
0.0	0.1	GO:0034497	protein localization to pre-autophagosomal structure(GO:0034497)
0.0	0.1	GO:0000160	phosphorelay signal transduction system(GO:0000160)
0.0	0.0	GO:0035973	aggrephagy(GO:0035973)
0.0	0.0	GO:0061502	early endosome to recycling endosome transport(GO:0061502)
0.0	0.0	GO:0051121	hepoxilin metabolic process(GO:0051121) hepoxilin biosynthetic process(GO:0051122)
0.0	0.0	GO:0051410	detoxification of nitrogen compound(GO:0051410) cellular detoxification of nitrogen compound(GO:0070458)
0.0	0.0	GO:0006391	transcription initiation from mitochondrial promoter(GO:0006391)
0.0	0.0	GO:0043321	regulation of natural killer cell degranulation(GO:0043321)
0.0	0.1	GO:0070544	histone H3-K36 demethylation(GO:0070544)
0.0	0.0	GO:0006203	dGTP catabolic process(GO:0006203)
0.0	0.1	GO:0061299	retina vasculature morphogenesis in camera-type eye(GO:0061299)
0.0	0.1	GO:0090324	negative regulation of oxidative phosphorylation(GO:0090324)
0.0	0.1	GO:2000678	negative regulation of transcription regulatory region DNA binding(GO:2000678)
0.0	0.1	GO:0090232	positive regulation of spindle checkpoint(GO:0090232)
0.0	0.0	GO:0036394	amylase secretion(GO:0036394)
0.0	0.0	GO:0046533	negative regulation of photoreceptor cell differentiation(GO:0046533)
0.0	0.0	GO:0042167	heme catabolic process(GO:0042167) pigment catabolic process(GO:0046149)
0.0	0.1	GO:0051574	positive regulation of histone H3-K9 methylation(GO:0051574)
0.0	0.0	GO:0090230	regulation of centromere complex assembly(GO:0090230)
0.0	0.0	GO:0060398	regulation of growth hormone receptor signaling pathway(GO:0060398)
0.0	0.0	GO:0061687	detoxification of copper ion(GO:0010273) detoxification of inorganic compound(GO:0061687) stress response to copper ion(GO:1990169)
0.0	0.2	GO:0009225	nucleotide-sugar metabolic process(GO:0009225)
0.0	0.0	GO:0035865	response to potassium ion(GO:0035864) cellular response to potassium ion(GO:0035865)
0.0	0.0	GO:0009448	gamma-aminobutyric acid metabolic process(GO:0009448)
0.0	0.0	GO:0060368	regulation of Fc receptor mediated stimulatory signaling pathway(GO:0060368)
0.0	0.0	GO:0070103	regulation of interleukin-6-mediated signaling pathway(GO:0070103)
0.0	0.1	GO:0036289	peptidyl-serine autophosphorylation(GO:0036289)
0.0	0.0	GO:0061366	behavioral response to chemical pain(GO:0061366) behavioral response to formalin induced pain(GO:0061368)
0.0	0.1	GO:0035646	endosome to melanosome transport(GO:0035646) endosome to pigment granule transport(GO:0043485) pigment granule maturation(GO:0048757)
0.0	0.1	GO:0018904	ether metabolic process(GO:0018904)
0.0	0.1	GO:0071243	cellular response to arsenic-containing substance(GO:0071243)
0.0	0.0	GO:0061113	pancreas morphogenesis(GO:0061113)
0.0	0.1	GO:0070875	positive regulation of glycogen metabolic process(GO:0070875)
0.0	0.0	GO:0071677	positive regulation of mononuclear cell migration(GO:0071677)
0.0	0.1	GO:0001302	replicative cell aging(GO:0001302)
0.0	0.0	GO:0003344	pericardium morphogenesis(GO:0003344)
0.0	0.1	GO:0031936	negative regulation of chromatin silencing(GO:0031936)
0.0	0.0	GO:0060061	Spemann organizer formation(GO:0060061)
0.0	0.0	GO:0006533	aspartate catabolic process(GO:0006533)
0.0	0.0	GO:0045041	protein import into mitochondrial intermembrane space(GO:0045041)
0.0	0.1	GO:2000628	regulation of miRNA metabolic process(GO:2000628)
0.0	0.0	GO:0060916	mesenchymal cell proliferation involved in lung development(GO:0060916)
0.0	0.1	GO:0075525	viral translational termination-reinitiation(GO:0075525)
0.0	0.1	GO:0002002	regulation of angiotensin levels in blood(GO:0002002)
0.0	0.0	GO:0090038	negative regulation of protein kinase C signaling(GO:0090038)
0.0	0.0	GO:0043988	histone H3-S28 phosphorylation(GO:0043988)
0.0	0.0	GO:1902969	mitotic DNA replication(GO:1902969)
0.0	0.0	GO:0071139	resolution of recombination intermediates(GO:0071139)
0.0	0.2	GO:0042347	negative regulation of NF-kappaB import into nucleus(GO:0042347)
0.0	0.0	GO:0021800	cerebral cortex tangential migration(GO:0021800)
0.0	0.1	GO:0017196	N-terminal peptidyl-methionine acetylation(GO:0017196)
0.0	0.1	GO:0045792	negative regulation of cell size(GO:0045792)
0.0	0.0	GO:0045901	positive regulation of translational elongation(GO:0045901)
0.0	0.1	GO:0071257	cellular response to electrical stimulus(GO:0071257)
0.0	0.0	GO:0045915	positive regulation of catecholamine metabolic process(GO:0045915) positive regulation of dopamine metabolic process(GO:0045964)
0.0	0.0	GO:0042536	negative regulation of tumor necrosis factor biosynthetic process(GO:0042536)
0.0	0.1	GO:0060330	regulation of response to interferon-gamma(GO:0060330)
0.0	0.2	GO:0007190	activation of adenylate cyclase activity(GO:0007190)
0.0	0.1	GO:0006020	inositol metabolic process(GO:0006020)
0.0	0.2	GO:0030212	hyaluronan metabolic process(GO:0030212)
0.0	0.0	GO:0009173	UMP biosynthetic process(GO:0006222) pyrimidine ribonucleoside monophosphate metabolic process(GO:0009173) pyrimidine ribonucleoside monophosphate biosynthetic process(GO:0009174) UMP metabolic process(GO:0046049)
0.0	0.1	GO:0048170	positive regulation of long-term neuronal synaptic plasticity(GO:0048170)
0.0	0.0	GO:0050904	diapedesis(GO:0050904)
0.0	0.1	GO:0006346	methylation-dependent chromatin silencing(GO:0006346)
0.0	0.1	GO:0003334	keratinocyte development(GO:0003334)
0.0	0.0	GO:0021524	visceral motor neuron differentiation(GO:0021524)
0.0	0.0	GO:0060921	sinoatrial node cell differentiation(GO:0060921) sinoatrial node cell development(GO:0060931)
0.0	0.6	GO:0022900	electron transport chain(GO:0022900)
0.0	0.1	GO:0048242	epinephrine secretion(GO:0048242)
0.0	0.0	GO:0001555	oocyte growth(GO:0001555)
0.0	0.0	GO:0002838	negative regulation of response to tumor cell(GO:0002835) negative regulation of immune response to tumor cell(GO:0002838)
0.0	0.2	GO:0015701	bicarbonate transport(GO:0015701)
0.0	0.1	GO:0030497	fatty acid elongation(GO:0030497)
0.0	0.1	GO:0019511	peptidyl-proline hydroxylation(GO:0019511)
0.0	0.1	GO:0051451	myoblast migration(GO:0051451)
0.0	0.1	GO:0006465	signal peptide processing(GO:0006465)
0.0	0.0	GO:0060050	positive regulation of protein glycosylation(GO:0060050)
0.0	0.0	GO:0070384	Harderian gland development(GO:0070384)
0.0	0.0	GO:1990086	lens fiber cell apoptotic process(GO:1990086)
0.0	0.1	GO:0019370	leukotriene biosynthetic process(GO:0019370)
0.0	0.0	GO:1901509	regulation of endothelial tube morphogenesis(GO:1901509)
0.0	0.1	GO:0006104	succinyl-CoA metabolic process(GO:0006104)
0.0	0.0	GO:0070836	caveola assembly(GO:0070836)
0.0	0.0	GO:0086046	membrane depolarization during SA node cell action potential(GO:0086046)
0.0	0.0	GO:0035635	entry of bacterium into host cell(GO:0035635) regulation of entry of bacterium into host cell(GO:2000535)
0.0	0.2	GO:0030866	cortical actin cytoskeleton organization(GO:0030866)
0.0	0.0	GO:0031284	positive regulation of guanylate cyclase activity(GO:0031284)
0.0	0.1	GO:0021702	cerebellar Purkinje cell differentiation(GO:0021702)
0.0	0.1	GO:0043517	positive regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043517)
0.0	0.0	GO:0002051	osteoblast fate commitment(GO:0002051)
0.0	0.0	GO:0090187	positive regulation of pancreatic juice secretion(GO:0090187)
0.0	0.0	GO:0043504	mitochondrial DNA repair(GO:0043504)
0.0	0.0	GO:0050747	positive regulation of lipoprotein metabolic process(GO:0050747)
0.0	0.0	GO:0010746	regulation of plasma membrane long-chain fatty acid transport(GO:0010746)
0.0	0.0	GO:0018171	peptidyl-cysteine oxidation(GO:0018171)
0.0	0.2	GO:0006301	postreplication repair(GO:0006301)
0.0	0.1	GO:0032012	ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.0	0.3	GO:1902476	chloride transmembrane transport(GO:1902476)
0.0	0.0	GO:0034146	toll-like receptor 5 signaling pathway(GO:0034146)
0.0	0.0	GO:0060830	ciliary receptor clustering involved in smoothened signaling pathway(GO:0060830)
0.0	0.0	GO:0090074	negative regulation of protein homodimerization activity(GO:0090074)
0.0	0.0	GO:0070100	negative regulation of chemokine-mediated signaling pathway(GO:0070100)
0.0	0.0	GO:0002679	respiratory burst involved in defense response(GO:0002679)
0.0	0.1	GO:0090051	negative regulation of cell migration involved in sprouting angiogenesis(GO:0090051)
0.0	0.4	GO:0032418	lysosome localization(GO:0032418)
0.0	0.0	GO:0042519	tyrosine phosphorylation of Stat4 protein(GO:0042504) regulation of tyrosine phosphorylation of Stat4 protein(GO:0042519)
0.0	0.0	GO:2000382	positive regulation of mesoderm development(GO:2000382)
0.0	0.1	GO:0046598	positive regulation of viral entry into host cell(GO:0046598)
0.0	0.0	GO:0042998	positive regulation of Golgi to plasma membrane protein transport(GO:0042998)
0.0	0.1	GO:0035994	response to muscle stretch(GO:0035994)
0.0	0.0	GO:0006269	DNA replication, synthesis of RNA primer(GO:0006269)
0.0	0.1	GO:0090136	epithelial cell-cell adhesion(GO:0090136)
0.0	0.0	GO:0015746	tricarboxylic acid transport(GO:0006842) citrate transport(GO:0015746)
0.0	0.0	GO:0034443	regulation of lipoprotein oxidation(GO:0034442) negative regulation of lipoprotein oxidation(GO:0034443)
0.0	0.0	GO:0060718	chorionic trophoblast cell differentiation(GO:0060718)
0.0	0.1	GO:0045292	mRNA cis splicing, via spliceosome(GO:0045292)
0.0	0.1	GO:1901409	regulation of phosphorylation of RNA polymerase II C-terminal domain(GO:1901407) positive regulation of phosphorylation of RNA polymerase II C-terminal domain(GO:1901409)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.6	GO:0005577	fibrinogen complex(GO:0005577)
0.1	0.2	GO:0032127	dense core granule membrane(GO:0032127)
0.1	0.3	GO:0061574	ASAP complex(GO:0061574)
0.1	0.3	GO:0097425	smooth endoplasmic reticulum membrane(GO:0030868) smooth endoplasmic reticulum part(GO:0097425)
0.1	0.4	GO:0089717	spanning component of plasma membrane(GO:0044214) spanning component of membrane(GO:0089717)
0.1	0.2	GO:0097443	sorting endosome(GO:0097443)
0.1	0.1	GO:0097057	TRAF2-GSTP1 complex(GO:0097057)
0.1	0.2	GO:0005899	insulin receptor complex(GO:0005899)
0.0	0.1	GO:0032937	SREBP-SCAP-Insig complex(GO:0032937)
0.0	0.3	GO:0070937	CRD-mediated mRNA stability complex(GO:0070937)
0.0	0.4	GO:0000164	protein phosphatase type 1 complex(GO:0000164)
0.0	0.1	GO:0036488	CHOP-C/EBP complex(GO:0036488)
0.0	0.3	GO:0031211	serine C-palmitoyltransferase complex(GO:0017059) endoplasmic reticulum palmitoyltransferase complex(GO:0031211)
0.0	0.1	GO:1990604	IRE1-TRAF2-ASK1 complex(GO:1990604)
0.0	0.1	GO:0071141	SMAD protein complex(GO:0071141)
0.0	0.1	GO:1903349	omegasome membrane(GO:1903349)
0.0	0.1	GO:0071001	U4/U6 snRNP(GO:0071001)
0.0	0.1	GO:0035189	Rb-E2F complex(GO:0035189)
0.0	0.1	GO:0000811	GINS complex(GO:0000811)
0.0	0.1	GO:0070110	ciliary neurotrophic factor receptor complex(GO:0070110)
0.0	0.1	GO:0033093	Weibel-Palade body(GO:0033093)
0.0	0.1	GO:0034274	Atg12-Atg5-Atg16 complex(GO:0034274)
0.0	0.3	GO:0016580	Sin3 complex(GO:0016580)
0.0	0.2	GO:0033256	I-kappaB/NF-kappaB complex(GO:0033256)
0.0	0.2	GO:0035749	myelin sheath adaxonal region(GO:0035749)
0.0	0.3	GO:0046581	intercellular canaliculus(GO:0046581)
0.0	0.1	GO:0033553	rDNA heterochromatin(GO:0033553)
0.0	0.1	GO:0044354	pinosome(GO:0044352) macropinosome(GO:0044354)
0.0	0.2	GO:0030893	meiotic cohesin complex(GO:0030893)
0.0	0.1	GO:0090571	RNA polymerase II transcription repressor complex(GO:0090571)
0.0	0.2	GO:0002116	semaphorin receptor complex(GO:0002116)
0.0	0.2	GO:0031931	TORC1 complex(GO:0031931)
0.0	0.1	GO:0000138	Golgi trans cisterna(GO:0000138)
0.0	0.1	GO:0005797	Golgi medial cisterna(GO:0005797)
0.0	0.1	GO:0009331	glycerol-3-phosphate dehydrogenase complex(GO:0009331)
0.0	0.1	GO:0070847	core mediator complex(GO:0070847)
0.0	0.1	GO:0005796	Golgi lumen(GO:0005796)
0.0	0.1	GO:1990761	growth cone lamellipodium(GO:1990761)
0.0	0.2	GO:0030061	mitochondrial crista(GO:0030061)
0.0	0.8	GO:0031519	PcG protein complex(GO:0031519)
0.0	0.1	GO:0034366	spherical high-density lipoprotein particle(GO:0034366)
0.0	0.1	GO:0097058	CRLF-CLCF1 complex(GO:0097058)
0.0	0.1	GO:0005745	m-AAA complex(GO:0005745)
0.0	0.3	GO:0005671	Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)
0.0	0.1	GO:0005677	chromatin silencing complex(GO:0005677)
0.0	0.2	GO:0042405	nuclear inclusion body(GO:0042405)
0.0	0.2	GO:0042612	MHC class I protein complex(GO:0042612)
0.0	0.1	GO:0097648	G-protein coupled receptor dimeric complex(GO:0038037) G-protein coupled receptor complex(GO:0097648)
0.0	0.1	GO:0043083	synaptic cleft(GO:0043083)
0.0	0.1	GO:0032983	kainate selective glutamate receptor complex(GO:0032983)
0.0	0.1	GO:0042567	insulin-like growth factor binding protein complex(GO:0016942) growth factor complex(GO:0036454) insulin-like growth factor ternary complex(GO:0042567)
0.0	0.2	GO:0090533	cation-transporting ATPase complex(GO:0090533)
0.0	0.1	GO:0005642	annulate lamellae(GO:0005642)
0.0	0.1	GO:0070695	FHF complex(GO:0070695)
0.0	0.1	GO:0008024	cyclin/CDK positive transcription elongation factor complex(GO:0008024)
0.0	0.1	GO:0070578	RISC-loading complex(GO:0070578)
0.0	0.1	GO:0016589	NURF complex(GO:0016589)
0.0	0.0	GO:0036195	muscle cell projection(GO:0036194) muscle cell projection membrane(GO:0036195)
0.0	0.1	GO:0031838	haptoglobin-hemoglobin complex(GO:0031838)
0.0	0.1	GO:0044462	cell outer membrane(GO:0009279) cell envelope(GO:0030313) external encapsulating structure part(GO:0044462)
0.0	0.1	GO:0046696	lipopolysaccharide receptor complex(GO:0046696)
0.0	0.1	GO:0000812	Swr1 complex(GO:0000812)
0.0	0.1	GO:0005683	U7 snRNP(GO:0005683)
0.0	0.1	GO:0000805	X chromosome(GO:0000805)
0.0	0.0	GO:0030981	cortical microtubule cytoskeleton(GO:0030981)
0.0	0.2	GO:0005662	DNA replication factor A complex(GO:0005662)
0.0	0.1	GO:0072687	meiotic spindle(GO:0072687)
0.0	0.1	GO:0030121	AP-1 adaptor complex(GO:0030121)
0.0	0.3	GO:0005605	basal lamina(GO:0005605)
0.0	0.1	GO:0098553	integral component of cytoplasmic side of endoplasmic reticulum membrane(GO:0071458) integral component of lumenal side of endoplasmic reticulum membrane(GO:0071556) lumenal side of endoplasmic reticulum membrane(GO:0098553)
0.0	0.4	GO:0001772	immunological synapse(GO:0001772)
0.0	0.1	GO:0071797	LUBAC complex(GO:0071797)
0.0	0.2	GO:0005685	U1 snRNP(GO:0005685)
0.0	0.2	GO:0031235	intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.0	0.0	GO:0070552	BRISC complex(GO:0070552)
0.0	0.1	GO:0008541	proteasome regulatory particle, lid subcomplex(GO:0008541)
0.0	0.0	GO:0000172	ribonuclease MRP complex(GO:0000172)
0.0	0.0	GO:0034363	intermediate-density lipoprotein particle(GO:0034363)
0.0	0.0	GO:0043527	tRNA methyltransferase complex(GO:0043527)
0.0	0.1	GO:0042627	chylomicron(GO:0042627)
0.0	0.1	GO:0030062	mitochondrial tricarboxylic acid cycle enzyme complex(GO:0030062)
0.0	0.1	GO:0030008	TRAPP complex(GO:0030008)
0.0	0.5	GO:0000118	histone deacetylase complex(GO:0000118)
0.0	0.1	GO:0005964	phosphorylase kinase complex(GO:0005964)
0.0	0.0	GO:0032437	cuticular plate(GO:0032437)
0.0	0.0	GO:0098645	collagen type IV trimer(GO:0005587) network-forming collagen trimer(GO:0098642) collagen network(GO:0098645) basement membrane collagen trimer(GO:0098651)
0.0	0.0	GO:0097149	centralspindlin complex(GO:0097149)
0.0	0.0	GO:0043511	inhibin complex(GO:0043511)
0.0	0.3	GO:0030686	90S preribosome(GO:0030686)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	0.9	GO:0000293	ferric-chelate reductase activity(GO:0000293)
0.2	0.5	GO:0005350	purine nucleobase transmembrane transporter activity(GO:0005345) pyrimidine nucleobase transmembrane transporter activity(GO:0005350) nucleobase transmembrane transporter activity(GO:0015205)
0.1	0.4	GO:0004611	phosphoenolpyruvate carboxykinase activity(GO:0004611)
0.1	0.6	GO:0016841	ammonia-lyase activity(GO:0016841)
0.1	0.5	GO:0004740	pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740)
0.1	0.3	GO:0070698	type I activin receptor binding(GO:0070698)
0.1	0.8	GO:0031995	insulin-like growth factor II binding(GO:0031995)
0.1	0.4	GO:0001875	lipopolysaccharide receptor activity(GO:0001875)
0.1	0.4	GO:0015198	oligopeptide transporter activity(GO:0015198)
0.1	0.4	GO:0008390	testosterone 16-alpha-hydroxylase activity(GO:0008390)
0.1	0.2	GO:0050833	pyruvate transmembrane transporter activity(GO:0050833)
0.1	0.2	GO:0034739	histone deacetylase activity (H4-K16 specific)(GO:0034739)
0.1	0.4	GO:0008559	xenobiotic-transporting ATPase activity(GO:0008559)
0.1	0.3	GO:0016401	palmitoyl-CoA oxidase activity(GO:0016401)
0.1	0.2	GO:1901702	urate transmembrane transporter activity(GO:0015143) salt transmembrane transporter activity(GO:1901702)
0.1	0.3	GO:0043262	adenosine-diphosphatase activity(GO:0043262)
0.1	0.3	GO:0016623	aldehyde oxidase activity(GO:0004031) oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor(GO:0016623)
0.1	0.1	GO:0001226	RNA polymerase II transcription corepressor binding(GO:0001226)
0.1	0.3	GO:0050051	leukotriene-B4 20-monooxygenase activity(GO:0050051)
0.1	0.3	GO:0004468	lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468)
0.1	0.3	GO:0004758	serine C-palmitoyltransferase activity(GO:0004758)
0.0	0.1	GO:0008449	N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.0	0.2	GO:0008294	calcium- and calmodulin-responsive adenylate cyclase activity(GO:0008294)
0.0	0.3	GO:0070891	lipoteichoic acid binding(GO:0070891)
0.0	0.1	GO:0102007	lactonohydrolase activity(GO:0046573) acyl-L-homoserine-lactone lactonohydrolase activity(GO:0102007)
0.0	0.1	GO:0031697	beta-1 adrenergic receptor binding(GO:0031697)
0.0	0.2	GO:0003847	1-alkyl-2-acetylglycerophosphocholine esterase activity(GO:0003847)
0.0	0.1	GO:0004937	alpha1-adrenergic receptor activity(GO:0004937)
0.0	0.1	GO:0004103	choline kinase activity(GO:0004103)
0.0	0.2	GO:1990239	steroid hormone binding(GO:1990239)
0.0	0.1	GO:0004771	sterol esterase activity(GO:0004771)
0.0	0.2	GO:0004095	carnitine O-palmitoyltransferase activity(GO:0004095)
0.0	0.6	GO:0005092	GDP-dissociation inhibitor activity(GO:0005092)
0.0	0.3	GO:0034046	poly(G) binding(GO:0034046)
0.0	0.1	GO:0015182	L-asparagine transmembrane transporter activity(GO:0015182) L-glutamine transmembrane transporter activity(GO:0015186)
0.0	0.1	GO:0004691	cAMP-dependent protein kinase activity(GO:0004691)
0.0	0.2	GO:0004035	alkaline phosphatase activity(GO:0004035)
0.0	0.5	GO:0001846	opsonin binding(GO:0001846)
0.0	0.3	GO:1904264	ubiquitin protein ligase activity involved in ERAD pathway(GO:1904264)
0.0	0.5	GO:0016854	racemase and epimerase activity(GO:0016854)
0.0	0.1	GO:0004724	magnesium-dependent protein serine/threonine phosphatase activity(GO:0004724)
0.0	0.2	GO:0036033	mediator complex binding(GO:0036033)
0.0	0.1	GO:0019797	procollagen-proline 3-dioxygenase activity(GO:0019797)
0.0	0.2	GO:0001515	opioid peptide activity(GO:0001515)
0.0	0.3	GO:0010521	telomerase inhibitor activity(GO:0010521)
0.0	0.6	GO:0001594	trace-amine receptor activity(GO:0001594)
0.0	0.0	GO:0050692	DBD domain binding(GO:0050692)
0.0	0.2	GO:0015379	potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820)
0.0	0.3	GO:0070097	delta-catenin binding(GO:0070097)
0.0	0.3	GO:0003841	1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)
0.0	0.2	GO:0047391	alkylglycerophosphoethanolamine phosphodiesterase activity(GO:0047391)
0.0	0.1	GO:0034714	type III transforming growth factor beta receptor binding(GO:0034714)
0.0	0.4	GO:0030676	Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0	0.1	GO:0019776	Atg8 ligase activity(GO:0019776)
0.0	0.1	GO:0000403	Y-form DNA binding(GO:0000403)
0.0	0.1	GO:0060230	lipoprotein lipase activator activity(GO:0060230)
0.0	0.2	GO:0042609	CD4 receptor binding(GO:0042609)
0.0	0.1	GO:0004459	L-lactate dehydrogenase activity(GO:0004459)
0.0	0.2	GO:0030976	thiamine pyrophosphate binding(GO:0030976)
0.0	0.2	GO:0048403	brain-derived neurotrophic factor binding(GO:0048403)
0.0	0.1	GO:0050693	LBD domain binding(GO:0050693)
0.0	0.1	GO:0032139	dinucleotide insertion or deletion binding(GO:0032139)
0.0	0.1	GO:0003886	DNA (cytosine-5-)-methyltransferase activity(GO:0003886) DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates(GO:0051718)
0.0	0.1	GO:0015377	cation:chloride symporter activity(GO:0015377)
0.0	0.1	GO:0005001	transmembrane receptor protein tyrosine phosphatase activity(GO:0005001)
0.0	0.1	GO:0015222	serotonin transmembrane transporter activity(GO:0015222)
0.0	0.1	GO:0015016	[heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.0	0.1	GO:0003976	UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity(GO:0003976)
0.0	0.1	GO:0090482	vitamin transmembrane transporter activity(GO:0090482)
0.0	0.2	GO:0016176	superoxide-generating NADPH oxidase activator activity(GO:0016176)
0.0	0.4	GO:0046703	natural killer cell lectin-like receptor binding(GO:0046703)
0.0	0.2	GO:0004385	guanylate kinase activity(GO:0004385)
0.0	0.1	GO:0035939	microsatellite binding(GO:0035939)
0.0	0.1	GO:0004126	cytidine deaminase activity(GO:0004126)
0.0	0.6	GO:0004407	histone deacetylase activity(GO:0004407)
0.0	0.3	GO:0017166	vinculin binding(GO:0017166)
0.0	0.1	GO:0005432	calcium:sodium antiporter activity(GO:0005432)
0.0	0.3	GO:0017154	semaphorin receptor activity(GO:0017154)
0.0	0.1	GO:0019158	fructokinase activity(GO:0008865) mannokinase activity(GO:0019158)
0.0	0.2	GO:0031432	titin binding(GO:0031432)
0.0	0.1	GO:0015183	L-aspartate transmembrane transporter activity(GO:0015183)
0.0	0.2	GO:0008440	inositol-1,4,5-trisphosphate 3-kinase activity(GO:0008440)
0.0	0.4	GO:0035259	glucocorticoid receptor binding(GO:0035259)
0.0	0.1	GO:0042895	antibiotic transporter activity(GO:0042895)
0.0	0.1	GO:0043237	laminin-1 binding(GO:0043237)
0.0	0.2	GO:0051864	histone demethylase activity (H3-K36 specific)(GO:0051864)
0.0	0.1	GO:0004985	opioid receptor activity(GO:0004985)
0.0	0.0	GO:0004630	phospholipase D activity(GO:0004630)
0.0	0.1	GO:0019808	polyamine binding(GO:0019808)
0.0	0.1	GO:0050649	testosterone 6-beta-hydroxylase activity(GO:0050649)
0.0	0.1	GO:0016716	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen(GO:0016716)
0.0	0.1	GO:0004826	phenylalanine-tRNA ligase activity(GO:0004826)
0.0	0.1	GO:0070290	N-acylphosphatidylethanolamine-specific phospholipase D activity(GO:0070290)
0.0	0.1	GO:0015319	sodium:inorganic phosphate symporter activity(GO:0015319)
0.0	0.2	GO:0015245	fatty acid transporter activity(GO:0015245)
0.0	0.1	GO:0004514	nicotinate-nucleotide diphosphorylase (carboxylating) activity(GO:0004514)
0.0	0.1	GO:0010997	anaphase-promoting complex binding(GO:0010997)
0.0	0.2	GO:0015194	L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889)
0.0	0.1	GO:0005436	sodium:phosphate symporter activity(GO:0005436)
0.0	0.1	GO:0004367	glycerol-3-phosphate dehydrogenase [NAD+] activity(GO:0004367)
0.0	0.0	GO:1990825	sequence-specific mRNA binding(GO:1990825)
0.0	0.6	GO:0051879	Hsp90 protein binding(GO:0051879)
0.0	0.3	GO:0043024	ribosomal small subunit binding(GO:0043024)
0.0	0.0	GO:0042910	xenobiotic transporter activity(GO:0042910)
0.0	0.1	GO:0070883	pre-miRNA binding(GO:0070883)
0.0	0.1	GO:0004594	pantothenate kinase activity(GO:0004594)
0.0	0.1	GO:0052650	NADP-retinol dehydrogenase activity(GO:0052650)
0.0	0.3	GO:0008143	poly(A) binding(GO:0008143)
0.0	0.1	GO:0004920	interleukin-10 receptor activity(GO:0004920)
0.0	0.1	GO:0042979	ornithine decarboxylase regulator activity(GO:0042979)
0.0	0.4	GO:0008157	protein phosphatase 1 binding(GO:0008157)
0.0	0.1	GO:0072345	NAADP-sensitive calcium-release channel activity(GO:0072345)
0.0	0.1	GO:0004965	G-protein coupled GABA receptor activity(GO:0004965)
0.0	0.2	GO:0070410	co-SMAD binding(GO:0070410)
0.0	0.1	GO:0004477	methenyltetrahydrofolate cyclohydrolase activity(GO:0004477) methylenetetrahydrofolate dehydrogenase (NAD+) activity(GO:0004487)
0.0	0.0	GO:0033300	dehydroascorbic acid transporter activity(GO:0033300)
0.0	0.1	GO:0005502	11-cis retinal binding(GO:0005502)
0.0	0.0	GO:1990188	euchromatin binding(GO:1990188)
0.0	0.3	GO:0017056	structural constituent of nuclear pore(GO:0017056)
0.0	0.0	GO:0097108	hedgehog family protein binding(GO:0097108)
0.0	0.1	GO:1990460	leptin receptor binding(GO:1990460)
0.0	0.0	GO:0003997	acyl-CoA oxidase activity(GO:0003997)
0.0	0.1	GO:0004703	G-protein coupled receptor kinase activity(GO:0004703)
0.0	0.1	GO:0015349	thyroid hormone transmembrane transporter activity(GO:0015349)
0.0	0.0	GO:0015556	C4-dicarboxylate transmembrane transporter activity(GO:0015556)
0.0	0.1	GO:0015037	peptide disulfide oxidoreductase activity(GO:0015037)
0.0	0.1	GO:1990715	mRNA CDS binding(GO:1990715)
0.0	0.1	GO:0000268	peroxisome targeting sequence binding(GO:0000268)
0.0	0.1	GO:0016901	oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor(GO:0016901)
0.0	0.2	GO:0008432	JUN kinase binding(GO:0008432)
0.0	0.0	GO:0015142	citrate transmembrane transporter activity(GO:0015137) tricarboxylic acid transmembrane transporter activity(GO:0015142)
0.0	0.5	GO:0016831	carboxy-lyase activity(GO:0016831)
0.0	0.1	GO:0015220	choline transmembrane transporter activity(GO:0015220)
0.0	0.1	GO:0052796	exo-alpha-sialidase activity(GO:0004308) alpha-sialidase activity(GO:0016997) exo-alpha-(2->3)-sialidase activity(GO:0052794) exo-alpha-(2->6)-sialidase activity(GO:0052795) exo-alpha-(2->8)-sialidase activity(GO:0052796)
0.0	0.1	GO:0050700	CARD domain binding(GO:0050700)
0.0	0.3	GO:0004012	phospholipid-translocating ATPase activity(GO:0004012)
0.0	0.2	GO:0043008	ATP-dependent protein binding(GO:0043008)
0.0	0.3	GO:0042813	Wnt-activated receptor activity(GO:0042813)
0.0	0.1	GO:0004427	inorganic diphosphatase activity(GO:0004427)
0.0	0.1	GO:0001665	alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity(GO:0001665)
0.0	0.1	GO:0046912	transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
0.0	0.1	GO:0016713	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen(GO:0016713)
0.0	0.2	GO:0005542	folic acid binding(GO:0005542)
0.0	0.0	GO:0005315	inorganic phosphate transmembrane transporter activity(GO:0005315)
0.0	0.1	GO:0031730	CCR5 chemokine receptor binding(GO:0031730)
0.0	0.0	GO:0030984	kininogen binding(GO:0030984)
0.0	0.1	GO:0102344	3-hydroxy-behenoyl-CoA dehydratase activity(GO:0102344) 3-hydroxy-lignoceroyl-CoA dehydratase activity(GO:0102345)
0.0	0.1	GO:0009922	fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)
0.0	0.1	GO:0036137	kynurenine-oxoglutarate transaminase activity(GO:0016212) kynurenine aminotransferase activity(GO:0036137)
0.0	0.3	GO:0008483	transaminase activity(GO:0008483)
0.0	0.0	GO:0031726	CCR1 chemokine receptor binding(GO:0031726)
0.0	0.2	GO:0030296	protein tyrosine kinase activator activity(GO:0030296)
0.0	0.0	GO:0047045	testosterone 17-beta-dehydrogenase (NADP+) activity(GO:0047045)
0.0	0.0	GO:0008427	calcium-dependent protein kinase inhibitor activity(GO:0008427)
0.0	0.1	GO:0035174	histone serine kinase activity(GO:0035174)
0.0	0.0	GO:0032767	copper-dependent protein binding(GO:0032767)
0.0	0.1	GO:0004322	ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.0	0.1	GO:0016936	galactoside binding(GO:0016936)
0.0	0.1	GO:0008297	single-stranded DNA exodeoxyribonuclease activity(GO:0008297)
0.0	0.0	GO:0004345	glucose-6-phosphate dehydrogenase activity(GO:0004345)
0.0	0.0	GO:0030957	Tat protein binding(GO:0030957)
0.0	0.1	GO:0070679	inositol 1,4,5 trisphosphate binding(GO:0070679)
0.0	0.0	GO:0004346	glucose-6-phosphatase activity(GO:0004346) sugar-terminal-phosphatase activity(GO:0050309)
0.0	0.0	GO:0034988	Fc-gamma receptor I complex binding(GO:0034988)
0.0	0.0	GO:0016774	phosphotransferase activity, carboxyl group as acceptor(GO:0016774)
0.0	0.0	GO:0004605	phosphatidate cytidylyltransferase activity(GO:0004605)
0.0	0.1	GO:0097157	pre-mRNA intronic binding(GO:0097157)
0.0	0.2	GO:0008327	methyl-CpG binding(GO:0008327)
0.0	0.1	GO:0097322	7SK snRNA binding(GO:0097322)
0.0	0.2	GO:0050998	nitric-oxide synthase binding(GO:0050998)
0.0	0.1	GO:0086080	protein binding involved in heterotypic cell-cell adhesion(GO:0086080)
0.0	0.1	GO:0035184	histone threonine kinase activity(GO:0035184)
0.0	0.1	GO:0008239	dipeptidyl-peptidase activity(GO:0008239)
0.0	0.0	GO:0019166	trans-2-enoyl-CoA reductase (NADPH) activity(GO:0019166)
0.0	0.0	GO:0004687	myosin light chain kinase activity(GO:0004687)
0.0	0.0	GO:0045134	uridine-diphosphatase activity(GO:0045134)
0.0	0.0	GO:0008808	cardiolipin synthase activity(GO:0008808) phosphatidyltransferase activity(GO:0030572)
0.0	0.0	GO:0004948	calcitonin receptor activity(GO:0004948)
0.0	0.0	GO:0000171	ribonuclease MRP activity(GO:0000171)
0.0	0.0	GO:0019961	interferon binding(GO:0019961)
0.0	0.0	GO:0003953	NAD+ nucleosidase activity(GO:0003953)
0.0	0.0	GO:0043120	tumor necrosis factor binding(GO:0043120)
0.0	0.0	GO:0070699	type II activin receptor binding(GO:0070699)
0.0	0.0	GO:0005128	erythropoietin receptor binding(GO:0005128)
0.0	0.0	GO:0004833	tryptophan 2,3-dioxygenase activity(GO:0004833)
0.0	0.1	GO:0017160	Ral GTPase binding(GO:0017160)
0.0	0.1	GO:0043023	ribosomal large subunit binding(GO:0043023)
0.0	0.1	GO:0045236	CXCR chemokine receptor binding(GO:0045236)
0.0	0.0	GO:0042289	MHC class II protein binding(GO:0042289)
0.0	0.1	GO:0016780	phosphotransferase activity, for other substituted phosphate groups(GO:0016780)
0.0	0.2	GO:0046966	thyroid hormone receptor binding(GO:0046966)
0.0	0.3	GO:0004683	calmodulin-dependent protein kinase activity(GO:0004683)
0.0	0.1	GO:0005138	interleukin-6 receptor binding(GO:0005138)
0.0	0.1	GO:0048156	tau protein binding(GO:0048156)
0.0	0.1	GO:0001013	RNA polymerase I regulatory region DNA binding(GO:0001013)
0.0	0.1	GO:0004303	estradiol 17-beta-dehydrogenase activity(GO:0004303)
0.0	0.2	GO:0000993	RNA polymerase II core binding(GO:0000993)
0.0	0.0	GO:0046404	ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity(GO:0046404) polydeoxyribonucleotide kinase activity(GO:0051733)
0.0	0.1	GO:0000155	phosphorelay sensor kinase activity(GO:0000155)
0.0	0.1	GO:0008889	glycerophosphodiester phosphodiesterase activity(GO:0008889)
0.0	0.1	GO:0015238	drug transmembrane transporter activity(GO:0015238)
0.0	0.1	GO:0019238	cyclohydrolase activity(GO:0019238)
0.0	0.6	GO:0030276	clathrin binding(GO:0030276)
0.0	0.1	GO:0008131	primary amine oxidase activity(GO:0008131)
0.0	0.0	GO:0016744	transferase activity, transferring aldehyde or ketonic groups(GO:0016744)
0.0	0.0	GO:0031752	D5 dopamine receptor binding(GO:0031752)
0.0	0.1	GO:0070006	metalloaminopeptidase activity(GO:0070006)
0.0	0.0	GO:0005329	dopamine transmembrane transporter activity(GO:0005329)
0.0	0.1	GO:0008121	ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.0	0.0	GO:0004558	alpha-1,4-glucosidase activity(GO:0004558)
0.0	0.0	GO:0005087	Ran guanyl-nucleotide exchange factor activity(GO:0005087)
0.0	0.0	GO:0045503	dynein light chain binding(GO:0045503)

Gene overrepresentation in curated gene sets: canonical pathways category:

Total log-likelihood	Term	Description
0.1	PID VEGF VEGFR PATHWAY	VEGF and VEGFR signaling network
0.9	PID TOLL ENDOGENOUS PATHWAY	Endogenous TLR signaling
0.7	PID INTEGRIN2 PATHWAY	Beta2 integrin cell surface interactions
0.4	PID LPA4 PATHWAY	LPA4-mediated signaling events
0.1	PID IL5 PATHWAY	IL5-mediated signaling events
0.5	PID HDAC CLASSIII PATHWAY	Signaling events mediated by HDAC Class III
0.2	PID S1P S1P4 PATHWAY	S1P4 pathway
0.2	PID NECTIN PATHWAY	Nectin adhesion pathway
0.1	ST IL 13 PATHWAY	Interleukin 13 (IL-13) Pathway
0.3	PID CIRCADIAN PATHWAY	Circadian rhythm pathway
0.1	PID ARF6 PATHWAY	Arf6 signaling events
0.2	PID INTEGRIN5 PATHWAY	Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.3	PID SMAD2 3PATHWAY	Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.5	PID HDAC CLASSII PATHWAY	Signaling events mediated by HDAC Class II
0.0	ST WNT CA2 CYCLIC GMP PATHWAY	Wnt/Ca2+/cyclic GMP signaling.
0.0	PID TXA2PATHWAY	Thromboxane A2 receptor signaling
0.4	PID WNT SIGNALING PATHWAY	Wnt signaling network
0.6	PID TGFBR PATHWAY	TGF-beta receptor signaling
0.1	SA G2 AND M PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.1	PID ERBB1 DOWNSTREAM PATHWAY	ErbB1 downstream signaling
0.1	SIG IL4RECEPTOR IN B LYPHOCYTES	Genes related to IL4 rceptor signaling in B lymphocytes
0.3	PID HIF2PATHWAY	HIF-2-alpha transcription factor network
0.2	PID HEDGEHOG 2PATHWAY	Signaling events mediated by the Hedgehog family
0.0	PID EPHA2 FWD PATHWAY	EPHA2 forward signaling
0.1	SA G1 AND S PHASES	Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
0.4	ST T CELL SIGNAL TRANSDUCTION	T Cell Signal Transduction

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.7	REACTOME IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION	Genes involved in IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
0.1	0.4	REACTOME BETA DEFENSINS	Genes involved in Beta defensins
0.1	0.5	REACTOME CREATION OF C4 AND C2 ACTIVATORS	Genes involved in Creation of C4 and C2 activators
0.1	0.6	REACTOME ABACAVIR TRANSPORT AND METABOLISM	Genes involved in Abacavir transport and metabolism
0.1	0.5	REACTOME PASSIVE TRANSPORT BY AQUAPORINS	Genes involved in Passive Transport by Aquaporins
0.1	0.7	REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS	Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.1	0.5	REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24 HYDROXYCHOLESTEROL	Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol
0.1	0.6	REACTOME COMMON PATHWAY	Genes involved in Common Pathway
0.1	0.6	REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS	Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.0	0.5	REACTOME ROLE OF DCC IN REGULATING APOPTOSIS	Genes involved in Role of DCC in regulating apoptosis
0.0	0.5	REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX	Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.0	0.1	REACTOME OLFACTORY SIGNALING PATHWAY	Genes involved in Olfactory Signaling Pathway
0.0	0.2	REACTOME REGULATION OF IFNA SIGNALING	Genes involved in Regulation of IFNA signaling
0.0	0.3	REACTOME ADENYLATE CYCLASE ACTIVATING PATHWAY	Genes involved in Adenylate cyclase activating pathway
0.0	0.1	REACTOME RNA POL I PROMOTER OPENING	Genes involved in RNA Polymerase I Promoter Opening
0.0	0.2	REACTOME ROLE OF SECOND MESSENGERS IN NETRIN1 SIGNALING	Genes involved in Role of second messengers in netrin-1 signaling
0.0	0.3	REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY	Genes involved in TRAF3-dependent IRF activation pathway
0.0	0.3	REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS	Genes involved in Facilitative Na+-independent glucose transporters
0.0	0.3	REACTOME NOTCH HLH TRANSCRIPTION PATHWAY	Genes involved in Notch-HLH transcription pathway
0.0	0.1	REACTOME ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON	Genes involved in Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
0.0	0.5	REACTOME RORA ACTIVATES CIRCADIAN EXPRESSION	Genes involved in RORA Activates Circadian Expression
0.0	0.1	REACTOME UNFOLDED PROTEIN RESPONSE	Genes involved in Unfolded Protein Response
0.0	0.0	REACTOME REGULATION OF INSULIN SECRETION BY GLUCAGON LIKE PEPTIDE1	Genes involved in Regulation of Insulin Secretion by Glucagon-like Peptide-1
0.0	0.1	REACTOME PYRUVATE METABOLISM	Genes involved in Pyruvate metabolism
0.0	0.2	REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE	Genes involved in Sema4D induced cell migration and growth-cone collapse
0.0	0.1	REACTOME RIP MEDIATED NFKB ACTIVATION VIA DAI	Genes involved in RIP-mediated NFkB activation via DAI
0.0	0.2	REACTOME SYNTHESIS OF PE	Genes involved in Synthesis of PE
0.0	0.3	REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY	Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.0	0.2	REACTOME IL 6 SIGNALING	Genes involved in Interleukin-6 signaling
0.0	1.7	REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION	Genes involved in Factors involved in megakaryocyte development and platelet production
0.0	0.2	REACTOME GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTERGRINS	Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins
0.0	0.2	REACTOME SOS MEDIATED SIGNALLING	Genes involved in SOS-mediated signalling
0.0	0.3	REACTOME TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX	Genes involved in TAK1 activates NFkB by phosphorylation and activation of IKKs complex
0.0	0.1	REACTOME REGULATION OF ORNITHINE DECARBOXYLASE ODC	Genes involved in Regulation of ornithine decarboxylase (ODC)
0.0	0.1	REACTOME DESTABILIZATION OF MRNA BY BRF1	Genes involved in Destabilization of mRNA by Butyrate Response Factor 1 (BRF1)
0.0	0.1	REACTOME INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1	Genes involved in Inhibition of replication initiation of damaged DNA by RB1/E2F1
0.0	0.0	REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES	Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)
0.0	0.4	REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION	Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.0	0.1	REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK	Genes involved in Negative regulation of the PI3K/AKT network
0.0	0.1	REACTOME VEGF LIGAND RECEPTOR INTERACTIONS	Genes involved in VEGF ligand-receptor interactions
0.0	0.1	REACTOME HYALURONAN UPTAKE AND DEGRADATION	Genes involved in Hyaluronan uptake and degradation
0.0	0.4	REACTOME TRAFFICKING OF AMPA RECEPTORS	Genes involved in Trafficking of AMPA receptors
0.0	0.2	REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS	Genes involved in Proteolytic cleavage of SNARE complex proteins
0.0	0.4	REACTOME TRANSPORT OF RIBONUCLEOPROTEINS INTO THE HOST NUCLEUS	Genes involved in Transport of Ribonucleoproteins into the Host Nucleus
0.0	0.1	REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS	Genes involved in Ionotropic activity of Kainate Receptors
0.0	0.1	REACTOME UNWINDING OF DNA	Genes involved in Unwinding of DNA
0.0	0.1	REACTOME ERKS ARE INACTIVATED	Genes involved in ERKs are inactivated
0.0	0.4	REACTOME ION TRANSPORT BY P TYPE ATPASES	Genes involved in Ion transport by P-type ATPases
0.0	0.1	REACTOME PECAM1 INTERACTIONS	Genes involved in PECAM1 interactions
0.0	0.1	REACTOME AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL	Genes involved in AKT phosphorylates targets in the cytosol
0.0	0.2	REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY	Genes involved in Post-chaperonin tubulin folding pathway
0.0	0.3	REACTOME SULFUR AMINO ACID METABOLISM	Genes involved in Sulfur amino acid metabolism
0.0	0.1	REACTOME ELONGATION ARREST AND RECOVERY	Genes involved in Elongation arrest and recovery
0.0	0.1	REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS	Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.0	0.1	REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION	Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.0	0.2	REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING	Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.0	0.3	REACTOME SYNTHESIS OF PA	Genes involved in Synthesis of PA
0.0	0.0	REACTOME FATTY ACYL COA BIOSYNTHESIS	Genes involved in Fatty Acyl-CoA Biosynthesis

Results for Six4

Z-value: 1.83

Motif logo

Transcription factors associated with Six4

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

Activity of the Six4 motif across conditions

Conditions sorted by the z-value of the Six4 motif activity

Top target CREs of the motif:

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of Six4

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: