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ENCSR904DTN: DNase-seq of mouse liver in constant darkness

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Results for Smad4

Z-value: 1.60

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Transcription factors associated with Smad4

Gene Symbol	Gene ID	Gene Info
Smad4 Ensembl NCBI MGI UniProt	ENSMUSG00000024515.7	SMAD family member 4

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
chr18_73674278_73674444	Smad4	757	0.604978	0.87	2.5e-02	Click!
chr18_73703748_73704065	Smad4	126	0.952348	-0.77	7.3e-02	Click!
chr18_73697259_73697432	Smad4	6435	0.159697	0.77	7.5e-02	Click!
chr18_73702216_73702367	Smad4	1489	0.339216	0.72	1.0e-01	Click!
chr18_73697728_73697893	Smad4	5970	0.161936	0.35	5.0e-01	Click!

Activity of the Smad4 motif across conditions

Conditions sorted by the z-value of the Smad4 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr8_35409885_35410137	0.97	Gm45301	predicted gene 45301	505	0.77
chr15_59020942_59021093	0.95	Mtss1	MTSS I-BAR domain containing 1	19579	0.18
chr4_120973741_120974003	0.93	Mir7015	microRNA 7015	550	0.63
chr6_72125643_72125794	0.90	4933431G14Rik	RIKEN cDNA 4933431G14 gene	2521	0.19
chr19_44397401_44397552	0.88	Scd1	stearoyl-Coenzyme A desaturase 1	9214	0.14
chr15_58987050_58987409	0.87	4930544F09Rik	RIKEN cDNA 4930544F09 gene	3093	0.22
chr11_72609282_72609433	0.85	Ube2g1	ubiquitin-conjugating enzyme E2G 1	2038	0.25
chr2_72157539_72157839	0.81	Rapgef4os1	Rap guanine nucleotide exchange factor (GEF) 4, opposite strand 1	8893	0.2
chr11_60201956_60202762	0.80	Mir6922	microRNA 6922	32	0.63
chr19_18145861_18146289	0.78	Gm18610	predicted gene, 18610	59720	0.14
chr12_3647979_3648147	0.78	Dtnb	dystrobrevin, beta	15141	0.21
chr13_20660427_20660704	0.76	Gm47721	predicted gene, 47721	14808	0.21
chr11_16755355_16755534	0.75	Egfr	epidermal growth factor receptor	3214	0.26
chr4_131722484_131723038	0.74	Gm16080	predicted gene 16080	12253	0.19
chr11_63851634_63851785	0.74	Hmgb1-ps3	high mobility group box 1, pseudogene 3	4891	0.25
chr15_58895415_58895566	0.73	Rnf139	ring finger protein 139	4647	0.14
chr8_114139321_114139472	0.72	Nudt7	nudix (nucleoside diphosphate linked moiety X)-type motif 7	5754	0.3
chr11_75173089_75173918	0.71	Mir212	microRNA 212	115	0.56
chr9_122056238_122056617	0.71	Gm39465	predicted gene, 39465	4964	0.13
chr11_101342858_101343022	0.71	Gm28156	predicted gene 28156	4999	0.06
chr9_106234042_106234256	0.71	Alas1	aminolevulinic acid synthase 1	2935	0.14
chrY_90803741_90803892	0.70	Gm47283	predicted gene, 47283	13365	0.17
chr3_97651056_97651341	0.70	Prkab2	protein kinase, AMP-activated, beta 2 non-catalytic subunit	6995	0.14
chr6_23121749_23122234	0.70	Aass	aminoadipate-semialdehyde synthase	5589	0.18
chr7_72216332_72216639	0.68	Mctp2	multiple C2 domains, transmembrane 2	12875	0.25
chr8_93179883_93180034	0.68	Ces1d	carboxylesterase 1D	4669	0.15
chr4_117937720_117937882	0.66	Artn	artemin	8038	0.12
chr6_143857686_143858000	0.66	Sox5	SRY (sex determining region Y)-box 5	89245	0.09
chr11_28689224_28689493	0.65	2810471M01Rik	RIKEN cDNA 2810471M01 gene	7794	0.19
chr15_3432918_3433085	0.63	Ghr	growth hormone receptor	38643	0.2
chr8_42183376_42183557	0.62	Gm6180	predicted pseudogene 6180	63445	0.14
chr9_106232444_106232608	0.61	Alas1	aminolevulinic acid synthase 1	4558	0.11
chr12_51274477_51274668	0.60	Rps11-ps4	ribosomal protein S11, pseudogene 4	22915	0.22
chr5_125512652_125512844	0.59	Aacs	acetoacetyl-CoA synthetase	49	0.97
chr7_97424078_97424348	0.59	Thrsp	thyroid hormone responsive	6483	0.13
chr5_143771106_143771348	0.59	Gm42503	predicted gene 42503	1187	0.41
chr15_42296635_42296795	0.58	Gm49452	predicted gene, 49452	23631	0.17
chr3_95881097_95881422	0.57	Ciart	circadian associated repressor of transcription	13	0.94
chr5_77314693_77314994	0.57	Gm42758	predicted gene 42758	3812	0.15
chr14_21195621_21195893	0.56	Adk	adenosine kinase	119605	0.05
chr4_118031195_118031493	0.56	St3gal3	ST3 beta-galactoside alpha-2,3-sialyltransferase 3	538	0.78
chr2_31479250_31479512	0.56	Ass1	argininosuccinate synthetase 1	9174	0.19
chr19_4594662_4594855	0.55	Pcx	pyruvate carboxylase	350	0.8
chr10_18197196_18197617	0.53	Ect2l	epithelial cell transforming sequence 2 oncogene-like	3947	0.22
chr9_74993629_74993780	0.52	Fam214a	family with sequence similarity 214, member A	17593	0.17
chr4_141958726_141958886	0.52	Fhad1	forkhead-associated (FHA) phosphopeptide binding domain 1	4612	0.15
chrX_140591571_140591781	0.51	AL683809.1	TSC22 domain family, member 3 (Tsc22d3), pseuodgene	8077	0.17
chr2_73591851_73592008	0.51	Chn1os3	chimerin 1, opposite strand 3	4597	0.16
chr3_129584585_129584736	0.51	Elovl6	ELOVL family member 6, elongation of long chain fatty acids (yeast)	32280	0.14
chr3_28718821_28719132	0.51	Slc2a2	solute carrier family 2 (facilitated glucose transporter), member 2	2541	0.24
chr4_151043729_151043930	0.50	Per3	period circadian clock 3	836	0.56
chr11_16818941_16819203	0.50	Egfros	epidermal growth factor receptor, opposite strand	11630	0.22
chr7_101344939_101345805	0.50	Gm45620	predicted gene 45620	2612	0.13
chr19_40180011_40180165	0.50	Cyp2c70	cytochrome P450, family 2, subfamily c, polypeptide 70	7198	0.16
chr1_21250942_21251436	0.49	Gsta3	glutathione S-transferase, alpha 3	2332	0.18
chr11_52350722_52351028	0.49	Vdac1	voltage-dependent anion channel 1	9985	0.17
chr2_32524318_32524490	0.49	Gm13412	predicted gene 13412	627	0.55
chr1_21248546_21248733	0.49	Gsta3	glutathione S-transferase, alpha 3	4882	0.13
chr5_148996162_148996678	0.49	Gm15406	predicted gene 15406	89	0.9
chr14_30534118_30534505	0.48	Dcp1a	decapping mRNA 1A	10604	0.14
chr19_40164076_40164449	0.47	Cyp2c70	cytochrome P450, family 2, subfamily c, polypeptide 70	23024	0.14
chrX_75673853_75674412	0.46	Gm15065	predicted gene 15065	31277	0.13
chr8_121980914_121981086	0.46	Banp	BTG3 associated nuclear protein	2678	0.16
chr2_177900583_177900745	0.46	Gm14327	predicted gene 14327	3568	0.18
chr5_125479676_125479838	0.46	Gm27551	predicted gene, 27551	380	0.78
chr9_44484103_44484412	0.46	Gm47205	predicted gene, 47205	454	0.54
chr2_134843502_134843690	0.46	Gm14036	predicted gene 14036	39647	0.17
chr4_60672835_60672986	0.46	Mup-ps7	major urinary protein, pseudogene 7	4773	0.19
chr4_99036770_99036925	0.45	Angptl3	angiopoietin-like 3	3644	0.22
chr5_23562685_23562882	0.45	Srpk2	serine/arginine-rich protein specific kinase 2	13413	0.19
chr12_104345688_104345839	0.45	Serpina3k	serine (or cysteine) peptidase inhibitor, clade A, member 3K	7277	0.12
chr12_21302020_21302503	0.44	Cpsf3	cleavage and polyadenylation specificity factor 3	990	0.4
chr14_58709638_58709806	0.44	Gm25614	predicted gene, 25614	59322	0.15
chr19_44400900_44401269	0.44	Scd1	stearoyl-Coenzyme A desaturase 1	5606	0.16
chr8_93176743_93176912	0.44	Ces1d	carboxylesterase 1D	1538	0.3
chr1_153741660_153741824	0.44	Rgs16	regulator of G-protein signaling 16	1393	0.25
chr4_31964283_31964752	0.44	Map3k7	mitogen-activated protein kinase kinase kinase 7	254	0.93
chr6_85811078_85811251	0.43	Nat8f6	N-acetyltransferase 8 (GCN5-related) family member 6	1301	0.25
chr17_81376267_81376581	0.43	Gm50044	predicted gene, 50044	5591	0.28
chr11_115905852_115906018	0.43	Recql5	RecQ protein-like 5	1318	0.24
chr18_77784597_77784781	0.43	Atp5a1	ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1	4857	0.15
chr3_14840901_14841063	0.43	Car3	carbonic anhydrase 3	22530	0.15
chr16_92610894_92611062	0.43	Gm26626	predicted gene, 26626	1836	0.39
chr12_104085193_104085357	0.43	Serpina4-ps1	serine (or cysteine) peptidase inhibitor, clade A, member 4, pseudogene 1	4626	0.11
chr17_45999890_46000044	0.43	Vegfa	vascular endothelial growth factor A	21405	0.15
chr10_4590008_4590159	0.42	Gm3266	predicted gene 3266	19860	0.18
chr2_160483998_160484149	0.42	Gm14222	predicted gene 14222	99284	0.07
chr10_26752927_26753096	0.42	Arhgap18	Rho GTPase activating protein 18	410	0.83
chrY_90807232_90807393	0.42	Gm47283	predicted gene, 47283	16861	0.16
chr5_125040097_125040498	0.42	Ncor2	nuclear receptor co-repressor 2	2515	0.25
chr9_74911852_74912214	0.42	Fam214a	family with sequence similarity 214, member A	40851	0.11
chr4_122935638_122935854	0.42	Gm12891	predicted gene 12891	9913	0.14
chr15_59065322_59065483	0.42	Mtss1	MTSS I-BAR domain containing 1	9938	0.23
chr13_56440067_56440428	0.42	Slc25a48	solute carrier family 25, member 48	1892	0.29
chrY_90807930_90808086	0.41	Gm47283	predicted gene, 47283	17557	0.16
chr1_80244319_80244685	0.41	Gm37932	predicted gene, 37932	11695	0.13
chr2_31491482_31491666	0.41	Ass1	argininosuccinate synthetase 1	6198	0.2
chr9_101082169_101082333	0.41	Msl2	MSL complex subunit 2	7489	0.12
chr11_101291651_101291851	0.41	Becn1	beclin 1, autophagy related	747	0.35
chr3_90081344_90081692	0.41	Tpm3	tropomyosin 3, gamma	1076	0.29
chr9_107328322_107328506	0.41	Hemk1	HemK methyltransferase family member 1	1038	0.35
chr7_81707314_81707700	0.41	Homer2	homer scaffolding protein 2	20	0.97
chr1_21264707_21265188	0.40	Gm28836	predicted gene 28836	6646	0.11
chr3_60525375_60525543	0.40	Mbnl1	muscleblind like splicing factor 1	2669	0.31
chr16_26669940_26670091	0.40	Il1rap	interleukin 1 receptor accessory protein	45859	0.18
chr16_43101819_43101970	0.39	Gm25873	predicted gene, 25873	24339	0.22
chr13_46052359_46052539	0.39	Gm45949	predicted gene, 45949	8148	0.26
chr2_147989793_147989944	0.39	9030622O22Rik	RIKEN cDNA 9030622O22 gene	13683	0.21
chr5_21737297_21737945	0.38	Pmpcb	peptidase (mitochondrial processing) beta	415	0.77
chr2_67898259_67898744	0.38	Gm37964	predicted gene, 37964	95	0.98
chr14_11803342_11803591	0.38	Gm48602	predicted gene, 48602	35523	0.19
chr8_120179504_120179692	0.38	Fam92b	family with sequence similarity 92, member B	2132	0.25
chr6_85835048_85835221	0.38	Nat8	N-acetyltransferase 8 (GCN5-related)	3052	0.12
chr1_21259850_21260251	0.37	Gsta3	glutathione S-transferase, alpha 3	6529	0.11
chr1_70918162_70918313	0.37	Gm16236	predicted gene 16236	121793	0.06
chr11_28698214_28698534	0.37	2810471M01Rik	RIKEN cDNA 2810471M01 gene	16810	0.16
chr8_26078485_26078636	0.37	Hook3	hook microtubule tethering protein 3	817	0.46
chr14_59540860_59541047	0.36	Cdadc1	cytidine and dCMP deaminase domain containing 1	56883	0.1
chr5_125479434_125479671	0.36	Gm27551	predicted gene, 27551	175	0.92
chr1_162892140_162892544	0.36	Fmo2	flavin containing monooxygenase 2	5827	0.19
chr10_123536278_123536442	0.36	Gm19169	predicted gene, 19169	47228	0.17
chr2_155061918_155062357	0.36	Gm45609	predicted gene 45609	12044	0.13
chr1_91514960_91515111	0.36	Traf3ip1	TRAF3 interacting protein 1	3227	0.17
chr12_12793762_12793936	0.36	Platr19	pluripotency associated transcript 19	5864	0.21
chr7_63916436_63916647	0.36	E030018B13Rik	RIKEN cDNA E030018B13 gene	316	0.85
chr6_85763706_85763876	0.36	Nat8f3	N-acetyltransferase 8 (GCN5-related) family member 3	1311	0.27
chr6_85709780_85709938	0.36	Nat8f7	N-acetyltransferase 8 (GCN5-related) family member 7	2001	0.2
chr3_138282244_138282429	0.36	Adh1	alcohol dehydrogenase 1 (class I)	4685	0.14
chr7_40677483_40677882	0.35	4933402C06Rik	RIKEN cDNA 4933402C06 gene	2945	0.3
chr15_62645080_62645285	0.35	Gm24810	predicted gene, 24810	7822	0.29
chr2_129865084_129865235	0.35	Stk35	serine/threonine kinase 35	64642	0.1
chr11_16862611_16863177	0.35	Egfr	epidermal growth factor receptor	15256	0.19
chr9_74526287_74526483	0.35	Gm28622	predicted gene 28622	34993	0.18
chr8_25754579_25754912	0.35	Ddhd2	DDHD domain containing 2	149	0.63
chr11_105281077_105281256	0.35	Mrc2	mannose receptor, C type 2	11477	0.19
chr14_29014453_29014621	0.35	Lrtm1	leucine-rich repeats and transmembrane domains 1	3671	0.23
chr5_102011072_102011265	0.35	Wdfy3	WD repeat and FYVE domain containing 3	29610	0.16
chr7_46727375_46727526	0.35	Saa4	serum amyloid A 4	5153	0.09
chr10_77441826_77442020	0.35	Gm35920	predicted gene, 35920	15994	0.15
chr9_44096490_44096809	0.35	Usp2	ubiquitin specific peptidase 2	3975	0.08
chr14_17823236_17823387	0.35	Gm48320	predicted gene, 48320	52189	0.17
chr15_59026303_59026454	0.35	Mtss1	MTSS I-BAR domain containing 1	14218	0.19
chr4_137005965_137006116	0.35	Zbtb40	zinc finger and BTB domain containing 40	14378	0.16
chr7_46727062_46727213	0.34	Saa4	serum amyloid A 4	5466	0.09
chr14_19808226_19808383	0.34	Nid2	nidogen 2	3068	0.21
chr16_93714548_93714944	0.34	Dop1b	DOP1 leucine zipper like protein B	1320	0.39
chr5_143526296_143526447	0.34	Gm42502	predicted gene 42502	711	0.52
chrY_90802780_90802931	0.34	Gm47283	predicted gene, 47283	12404	0.17
chr15_62329521_62329672	0.34	Pvt1	Pvt1 oncogene	106993	0.07
chr5_102643765_102644161	0.34	Arhgap24	Rho GTPase activating protein 24	81010	0.11
chr12_69759681_69759832	0.34	Mir681	microRNA 681	4188	0.15
chr2_58759818_58759990	0.34	Upp2	uridine phosphorylase 2	4692	0.23
chr9_24502048_24502199	0.34	Dpy19l1	dpy-19-like 1 (C. elegans)	1017	0.45
chr2_178026714_178026865	0.34	Zfp971	zinc finger protein 971	3410	0.24
chr15_97006005_97006390	0.34	Slc38a4	solute carrier family 38, member 4	13754	0.26
chr18_12720543_12720734	0.34	Mir1948	microRNA 1948	5827	0.15
chr7_30475671_30475822	0.33	Nphs1	nephrosis 1, nephrin	1238	0.2
chr13_34076065_34076216	0.33	Tubb2a	tubulin, beta 2A class IIA	1867	0.2
chr19_43778712_43778869	0.33	Abcc2	ATP-binding cassette, sub-family C (CFTR/MRP), member 2	3402	0.18
chr14_70380431_70380586	0.33	Gm9174	predicted pseudogene 9174	20321	0.1
chr19_4783214_4783365	0.33	Rbm4	RNA binding motif protein 4	10562	0.08
chr13_8849368_8849539	0.33	Wdr37	WD repeat domain 37	105	0.94
chr17_24882806_24883274	0.33	Nubp2	nucleotide binding protein 2	2577	0.11
chr7_99163511_99163819	0.33	Dgat2	diacylglycerol O-acyltransferase 2	6441	0.13
chr4_122982608_122982816	0.33	Mycl	v-myc avian myelocytomatosis viral oncogene lung carcinoma derived	12940	0.13
chr9_46099181_46099332	0.33	Sik3	SIK family kinase 3	23874	0.16
chr1_13587097_13587434	0.33	Tram1	translocating chain-associating membrane protein 1	2610	0.3
chr1_67178481_67179155	0.32	Cps1	carbamoyl-phosphate synthetase 1	55792	0.12
chr17_46019375_46019704	0.32	Vegfa	vascular endothelial growth factor A	1833	0.31
chr2_71607777_71607946	0.32	Dlx2	distal-less homeobox 2	61107	0.09
chr9_21248646_21249016	0.32	S1pr5	sphingosine-1-phosphate receptor 5	388	0.64
chr5_140112771_140112922	0.32	Mad1l1	MAD1 mitotic arrest deficient 1-like 1	2620	0.23
chr2_31513768_31514291	0.32	Ass1	argininosuccinate synthetase 1	4461	0.2
chr7_132943127_132943278	0.32	Zranb1	zinc finger, RAN-binding domain containing 1	4966	0.16
chr5_125467628_125467779	0.32	Gm43756	predicted gene 43756	3794	0.14
chr11_5525096_5525390	0.32	Xbp1	X-box binding protein 1	3320	0.17
chr15_82791292_82791711	0.32	Cyp2d26	cytochrome P450, family 2, subfamily d, polypeptide 26	2721	0.14
chr3_97649987_97650151	0.32	Prkab2	protein kinase, AMP-activated, beta 2 non-catalytic subunit	8124	0.13
chr5_33462368_33462568	0.32	Gm43851	predicted gene 43851	25004	0.15
chr6_146270994_146271175	0.32	Gm44086	predicted gene, 44086	104	0.97
chr5_22587487_22587999	0.31	Gm9057	predicted gene 9057	23786	0.11
chr2_148037591_148038164	0.31	9030622O22Rik	RIKEN cDNA 9030622O22 gene	393	0.84
chr9_80672553_80672726	0.31	Gm39380	predicted gene, 39380	37356	0.19
chr6_53070128_53070316	0.31	Jazf1	JAZF zinc finger 1	1591	0.41
chr8_61533482_61533653	0.31	Palld	palladin, cytoskeletal associated protein	274	0.94
chr1_21252081_21252232	0.31	Gsta3	glutathione S-transferase, alpha 3	1365	0.29
chr10_96107868_96108070	0.31	Gm49817	predicted gene, 49817	11964	0.16
chr5_136960851_136961002	0.31	Fis1	fission, mitochondrial 1	1151	0.29
chr9_35031413_35031583	0.31	Kirrel3	kirre like nephrin family adhesion molecule 3	15046	0.17
chrY_90799493_90799663	0.31	Gm47283	predicted gene, 47283	9127	0.18
chr1_41557400_41557596	0.30	Gm28634	predicted gene 28634	27955	0.26
chr7_70360531_70360745	0.30	Nr2f2	nuclear receptor subfamily 2, group F, member 2	45	0.96
chr2_155067847_155068055	0.30	Gm45609	predicted gene 45609	6230	0.14
chr13_96695184_96695498	0.30	Gm48575	predicted gene, 48575	17218	0.15
chr3_52011173_52011324	0.30	Gm37465	predicted gene, 37465	7223	0.13
chr3_94687768_94687919	0.30	Selenbp2	selenium binding protein 2	5713	0.11
chrY_90800164_90800315	0.30	Gm47283	predicted gene, 47283	9788	0.18
chr2_130894667_130894834	0.30	A730017L22Rik	RIKEN cDNA A730017L22 gene	11606	0.13
chr14_29976665_29976837	0.30	Actr8	ARP8 actin-related protein 8	1586	0.25
chr18_78777423_78777582	0.30	Gm23895	predicted gene, 23895	129374	0.05

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of Smad4

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View png image

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	0.7	GO:2001013	epithelial cell proliferation involved in renal tubule morphogenesis(GO:2001013)
0.2	0.6	GO:0003062	regulation of heart rate by chemical signal(GO:0003062)
0.2	0.5	GO:1903800	positive regulation of production of miRNAs involved in gene silencing by miRNA(GO:1903800)
0.2	0.5	GO:0010046	response to mycotoxin(GO:0010046)
0.1	0.7	GO:0044791	modulation by host of viral release from host cell(GO:0044789) positive regulation by host of viral release from host cell(GO:0044791)
0.1	0.4	GO:2000211	regulation of glutamate metabolic process(GO:2000211)
0.1	0.4	GO:0060528	secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development(GO:0060528)
0.1	0.3	GO:0019626	short-chain fatty acid catabolic process(GO:0019626)
0.1	0.3	GO:2000909	regulation of cholesterol import(GO:0060620) regulation of sterol import(GO:2000909)
0.1	0.3	GO:1901078	negative regulation of relaxation of muscle(GO:1901078)
0.1	0.2	GO:0072338	creatinine metabolic process(GO:0046449) cellular lactam metabolic process(GO:0072338)
0.1	0.3	GO:1903966	monounsaturated fatty acid metabolic process(GO:1903964) monounsaturated fatty acid biosynthetic process(GO:1903966)
0.1	0.4	GO:1903599	positive regulation of mitophagy(GO:1903599)
0.1	0.4	GO:0097343	ripoptosome assembly(GO:0097343) ripoptosome assembly involved in necroptotic process(GO:1901026)
0.1	0.1	GO:0071492	cellular response to UV-A(GO:0071492)
0.1	0.2	GO:0035790	platelet-derived growth factor receptor-alpha signaling pathway(GO:0035790)
0.1	0.8	GO:0009404	toxin metabolic process(GO:0009404)
0.1	0.3	GO:1990414	replication-born double-strand break repair via sister chromatid exchange(GO:1990414)
0.1	0.2	GO:1903999	negative regulation of eating behavior(GO:1903999)
0.1	0.1	GO:0034756	regulation of iron ion transport(GO:0034756)
0.1	0.3	GO:0007412	axon target recognition(GO:0007412)
0.1	0.2	GO:0060523	prostate epithelial cord elongation(GO:0060523)
0.1	0.2	GO:0010724	regulation of definitive erythrocyte differentiation(GO:0010724)
0.1	0.2	GO:0050882	voluntary musculoskeletal movement(GO:0050882)
0.1	0.1	GO:0072318	clathrin coat disassembly(GO:0072318)
0.1	0.1	GO:0019064	fusion of virus membrane with host plasma membrane(GO:0019064) membrane fusion involved in viral entry into host cell(GO:0039663) multi-organism membrane fusion(GO:0044800)
0.1	0.2	GO:0034454	microtubule anchoring at centrosome(GO:0034454)
0.1	0.2	GO:1903334	positive regulation of protein folding(GO:1903334)
0.1	0.2	GO:0000432	regulation of transcription from RNA polymerase II promoter by glucose(GO:0000430) positive regulation of transcription from RNA polymerase II promoter by glucose(GO:0000432)
0.1	0.2	GO:0006553	lysine metabolic process(GO:0006553)
0.1	0.3	GO:0070236	negative regulation of activation-induced cell death of T cells(GO:0070236)
0.1	0.4	GO:0060509	Type I pneumocyte differentiation(GO:0060509)
0.1	0.2	GO:2000143	negative regulation of transcription initiation from RNA polymerase II promoter(GO:0060633) negative regulation of DNA-templated transcription, initiation(GO:2000143)
0.1	0.2	GO:0006382	adenosine to inosine editing(GO:0006382)
0.1	0.2	GO:0042427	serotonin biosynthetic process(GO:0042427) primary amino compound biosynthetic process(GO:1901162)
0.1	0.1	GO:0032489	regulation of Cdc42 protein signal transduction(GO:0032489)
0.1	0.2	GO:1900045	negative regulation of protein K63-linked ubiquitination(GO:1900045) negative regulation of protein polyubiquitination(GO:1902915)
0.1	0.1	GO:0042117	monocyte activation(GO:0042117)
0.1	0.8	GO:0014041	regulation of neuron maturation(GO:0014041)
0.1	0.4	GO:0097011	cellular response to granulocyte macrophage colony-stimulating factor stimulus(GO:0097011)
0.1	0.3	GO:0060836	lymphatic endothelial cell differentiation(GO:0060836)
0.1	0.3	GO:2000510	positive regulation of dendritic cell chemotaxis(GO:2000510)
0.0	0.1	GO:0014732	skeletal muscle atrophy(GO:0014732)
0.0	0.1	GO:0034196	acylglycerol transport(GO:0034196) triglyceride transport(GO:0034197)
0.0	0.0	GO:1902498	regulation of protein autoubiquitination(GO:1902498)
0.0	0.3	GO:0060613	fat pad development(GO:0060613)
0.0	0.6	GO:0035584	calcium-mediated signaling using intracellular calcium source(GO:0035584)
0.0	0.2	GO:0018211	protein C-linked glycosylation(GO:0018103) peptidyl-tryptophan modification(GO:0018211) protein C-linked glycosylation via tryptophan(GO:0018317) protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan(GO:0018406)
0.0	0.2	GO:0097460	ferrous iron import into cell(GO:0097460)
0.0	0.1	GO:0002036	regulation of L-glutamate transport(GO:0002036)
0.0	0.2	GO:0009052	pentose-phosphate shunt, non-oxidative branch(GO:0009052)
0.0	0.3	GO:0006048	UDP-N-acetylglucosamine biosynthetic process(GO:0006048)
0.0	0.1	GO:0003011	involuntary skeletal muscle contraction(GO:0003011)
0.0	0.1	GO:0061625	fructose catabolic process(GO:0006001) fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate(GO:0061624) glycolytic process through fructose-1-phosphate(GO:0061625)
0.0	0.1	GO:0061146	Peyer's patch morphogenesis(GO:0061146)
0.0	0.4	GO:0055091	phospholipid homeostasis(GO:0055091)
0.0	0.1	GO:1900041	negative regulation of interleukin-2 secretion(GO:1900041)
0.0	0.1	GO:0036112	medium-chain fatty-acyl-CoA metabolic process(GO:0036112)
0.0	0.1	GO:2000111	positive regulation of macrophage apoptotic process(GO:2000111)
0.0	0.1	GO:0061470	T follicular helper cell differentiation(GO:0061470)
0.0	0.1	GO:0033566	gamma-tubulin complex localization(GO:0033566)
0.0	0.2	GO:1901300	positive regulation of hydrogen peroxide-mediated programmed cell death(GO:1901300) positive regulation of hydrogen peroxide-induced cell death(GO:1905206)
0.0	0.2	GO:1901894	regulation of calcium-transporting ATPase activity(GO:1901894)
0.0	0.2	GO:0034983	peptidyl-lysine deacetylation(GO:0034983)
0.0	0.2	GO:0051534	negative regulation of NFAT protein import into nucleus(GO:0051534)
0.0	0.1	GO:0051684	maintenance of Golgi location(GO:0051684)
0.0	0.2	GO:0070837	dehydroascorbic acid transport(GO:0070837)
0.0	0.6	GO:0045475	locomotor rhythm(GO:0045475)
0.0	0.2	GO:0006526	arginine biosynthetic process(GO:0006526)
0.0	0.2	GO:0038165	oncostatin-M-mediated signaling pathway(GO:0038165)
0.0	0.2	GO:0042997	negative regulation of Golgi to plasma membrane protein transport(GO:0042997)
0.0	0.1	GO:0097051	establishment of protein localization to endoplasmic reticulum membrane(GO:0097051)
0.0	0.1	GO:2001032	regulation of double-strand break repair via nonhomologous end joining(GO:2001032)
0.0	0.1	GO:2000338	chemokine (C-X-C motif) ligand 1 production(GO:0072566) regulation of chemokine (C-X-C motif) ligand 1 production(GO:2000338)
0.0	0.1	GO:1903525	regulation of membrane tubulation(GO:1903525)
0.0	0.1	GO:2000646	positive regulation of receptor catabolic process(GO:2000646)
0.0	0.1	GO:0048769	sarcomerogenesis(GO:0048769)
0.0	0.3	GO:2001256	regulation of store-operated calcium entry(GO:2001256)
0.0	0.1	GO:1902775	mitochondrial large ribosomal subunit assembly(GO:1902775)
0.0	0.1	GO:0036091	positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress(GO:0036091)
0.0	0.1	GO:0046121	deoxyribonucleoside catabolic process(GO:0046121)
0.0	0.2	GO:0098908	regulation of neuronal action potential(GO:0098908)
0.0	0.1	GO:0035589	G-protein coupled purinergic nucleotide receptor signaling pathway(GO:0035589)
0.0	0.2	GO:0060546	negative regulation of necroptotic process(GO:0060546)
0.0	0.2	GO:2000427	positive regulation of apoptotic cell clearance(GO:2000427)
0.0	0.1	GO:0070973	protein localization to endoplasmic reticulum exit site(GO:0070973)
0.0	0.0	GO:0046100	hypoxanthine metabolic process(GO:0046100) hypoxanthine biosynthetic process(GO:0046101)
0.0	0.4	GO:0006152	purine nucleoside catabolic process(GO:0006152) purine ribonucleoside catabolic process(GO:0046130)
0.0	0.0	GO:0046501	protoporphyrinogen IX metabolic process(GO:0046501)
0.0	0.2	GO:0003376	sphingosine-1-phosphate signaling pathway(GO:0003376)
0.0	0.2	GO:0042796	snRNA transcription from RNA polymerase III promoter(GO:0042796)
0.0	0.3	GO:0006122	mitochondrial electron transport, ubiquinol to cytochrome c(GO:0006122)
0.0	0.1	GO:1901475	pyruvate transmembrane transport(GO:1901475)
0.0	0.1	GO:0031087	nuclear-transcribed mRNA catabolic process, deadenylation-independent decay(GO:0031086) deadenylation-independent decapping of nuclear-transcribed mRNA(GO:0031087)
0.0	0.2	GO:0007021	tubulin complex assembly(GO:0007021)
0.0	0.4	GO:0071803	positive regulation of podosome assembly(GO:0071803)
0.0	0.1	GO:1990705	cholangiocyte proliferation(GO:1990705)
0.0	0.1	GO:0021960	anterior commissure morphogenesis(GO:0021960)
0.0	0.3	GO:0043651	linoleic acid metabolic process(GO:0043651)
0.0	0.1	GO:0006068	ethanol catabolic process(GO:0006068)
0.0	0.1	GO:0010572	positive regulation of platelet activation(GO:0010572)
0.0	0.1	GO:0046618	drug export(GO:0046618)
0.0	0.3	GO:0006120	mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.0	0.1	GO:0006642	triglyceride mobilization(GO:0006642)
0.0	0.2	GO:1902902	negative regulation of autophagosome assembly(GO:1902902)
0.0	0.1	GO:2000741	positive regulation of mesenchymal stem cell differentiation(GO:2000741)
0.0	0.1	GO:0002121	inter-male aggressive behavior(GO:0002121)
0.0	0.1	GO:0071895	odontoblast differentiation(GO:0071895)
0.0	0.1	GO:0072602	interleukin-4 secretion(GO:0072602)
0.0	0.1	GO:0042420	dopamine catabolic process(GO:0042420)
0.0	0.1	GO:1902065	response to L-glutamate(GO:1902065)
0.0	0.3	GO:0006750	glutathione biosynthetic process(GO:0006750)
0.0	0.1	GO:0019086	late viral transcription(GO:0019086)
0.0	0.8	GO:0070542	response to fatty acid(GO:0070542)
0.0	0.1	GO:0036135	Schwann cell migration(GO:0036135) regulation of Schwann cell migration(GO:1900147)
0.0	0.1	GO:0034080	CENP-A containing nucleosome assembly(GO:0034080) CENP-A containing chromatin organization(GO:0061641)
0.0	0.0	GO:0035973	aggrephagy(GO:0035973)
0.0	0.2	GO:2001275	positive regulation of glucose import in response to insulin stimulus(GO:2001275)
0.0	0.1	GO:0032713	negative regulation of interleukin-4 production(GO:0032713)
0.0	0.0	GO:2000739	regulation of mesenchymal stem cell differentiation(GO:2000739)
0.0	0.2	GO:1900103	positive regulation of endoplasmic reticulum unfolded protein response(GO:1900103)
0.0	0.0	GO:0070093	negative regulation of glucagon secretion(GO:0070093)
0.0	0.1	GO:0006398	mRNA 3'-end processing by stem-loop binding and cleavage(GO:0006398)
0.0	0.1	GO:0003164	His-Purkinje system development(GO:0003164)
0.0	0.4	GO:0001574	ganglioside biosynthetic process(GO:0001574)
0.0	0.1	GO:0032485	regulation of Ral protein signal transduction(GO:0032485)
0.0	0.0	GO:0021847	ventricular zone neuroblast division(GO:0021847)
0.0	0.2	GO:0042759	long-chain fatty acid biosynthetic process(GO:0042759)
0.0	0.1	GO:0035360	positive regulation of peroxisome proliferator activated receptor signaling pathway(GO:0035360)
0.0	0.2	GO:0042219	cellular modified amino acid catabolic process(GO:0042219)
0.0	0.1	GO:0021827	cerebral cortex tangential migration using cell-cell interactions(GO:0021823) postnatal olfactory bulb interneuron migration(GO:0021827)
0.0	0.1	GO:0050955	thermoception(GO:0050955)
0.0	0.1	GO:0043490	malate-aspartate shuttle(GO:0043490)
0.0	0.0	GO:0007529	establishment of synaptic specificity at neuromuscular junction(GO:0007529)
0.0	0.1	GO:0051574	positive regulation of histone H3-K9 methylation(GO:0051574)
0.0	0.1	GO:0035021	negative regulation of Rac protein signal transduction(GO:0035021)
0.0	0.0	GO:0042374	phylloquinone metabolic process(GO:0042374) phylloquinone catabolic process(GO:0042376) quinone catabolic process(GO:1901662)
0.0	0.2	GO:0000059	protein import into nucleus, docking(GO:0000059)
0.0	0.1	GO:0036092	phosphatidylinositol-3-phosphate biosynthetic process(GO:0036092)
0.0	0.5	GO:0006308	DNA catabolic process(GO:0006308)
0.0	0.0	GO:0044333	Wnt signaling pathway involved in digestive tract morphogenesis(GO:0044333)
0.0	0.3	GO:0060628	regulation of ER to Golgi vesicle-mediated transport(GO:0060628)
0.0	0.1	GO:0019805	quinolinate biosynthetic process(GO:0019805)
0.0	0.1	GO:0042525	tyrosine phosphorylation of Stat6 protein(GO:0042505) regulation of tyrosine phosphorylation of Stat6 protein(GO:0042525)
0.0	0.1	GO:0044034	negative stranded viral RNA replication(GO:0039689) multi-organism biosynthetic process(GO:0044034)
0.0	0.1	GO:0090206	negative regulation of cholesterol biosynthetic process(GO:0045541) negative regulation of cholesterol metabolic process(GO:0090206)
0.0	0.1	GO:0048496	maintenance of organ identity(GO:0048496)
0.0	0.1	GO:0017085	response to insecticide(GO:0017085)
0.0	0.1	GO:0030950	establishment or maintenance of actin cytoskeleton polarity(GO:0030950)
0.0	0.1	GO:0019254	carnitine metabolic process, CoA-linked(GO:0019254)
0.0	0.0	GO:2000286	receptor internalization involved in canonical Wnt signaling pathway(GO:2000286)
0.0	0.2	GO:0052697	xenobiotic glucuronidation(GO:0052697)
0.0	0.1	GO:0015770	disaccharide transport(GO:0015766) sucrose transport(GO:0015770) oligosaccharide transport(GO:0015772)
0.0	0.1	GO:0021882	regulation of transcription from RNA polymerase II promoter involved in forebrain neuron fate commitment(GO:0021882)
0.0	0.1	GO:0045908	negative regulation of vasodilation(GO:0045908)
0.0	0.0	GO:1901420	negative regulation of response to alcohol(GO:1901420)
0.0	0.1	GO:0006659	phosphatidylserine biosynthetic process(GO:0006659)
0.0	0.2	GO:0006707	cholesterol catabolic process(GO:0006707) sterol catabolic process(GO:0016127)
0.0	0.0	GO:0032484	Ral protein signal transduction(GO:0032484)
0.0	0.5	GO:0019373	epoxygenase P450 pathway(GO:0019373)
0.0	0.1	GO:0042414	epinephrine metabolic process(GO:0042414)
0.0	0.0	GO:0045085	negative regulation of interleukin-2 biosynthetic process(GO:0045085)
0.0	0.1	GO:0070245	positive regulation of thymocyte apoptotic process(GO:0070245)
0.0	0.1	GO:0006166	purine ribonucleoside salvage(GO:0006166)
0.0	0.0	GO:0010982	regulation of high-density lipoprotein particle clearance(GO:0010982)
0.0	0.1	GO:1990034	calcium ion export from cell(GO:1990034)
0.0	0.1	GO:0008343	adult feeding behavior(GO:0008343)
0.0	0.1	GO:1900747	negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747)
0.0	0.1	GO:0048541	mucosal-associated lymphoid tissue development(GO:0048537) Peyer's patch development(GO:0048541)
0.0	0.1	GO:0032055	negative regulation of translation in response to stress(GO:0032055)
0.0	0.0	GO:0042851	L-alanine metabolic process(GO:0042851)
0.0	0.2	GO:0070493	thrombin receptor signaling pathway(GO:0070493)
0.0	0.2	GO:1903779	regulation of cardiac conduction(GO:1903779)
0.0	0.1	GO:0002002	regulation of angiotensin levels in blood(GO:0002002)
0.0	0.1	GO:0036438	maintenance of lens transparency(GO:0036438)
0.0	0.3	GO:0017144	drug metabolic process(GO:0017144)
0.0	0.1	GO:0086046	membrane depolarization during SA node cell action potential(GO:0086046)
0.0	0.1	GO:0035414	negative regulation of catenin import into nucleus(GO:0035414)
0.0	0.1	GO:0045631	regulation of auditory receptor cell differentiation(GO:0045607) regulation of mechanoreceptor differentiation(GO:0045631) regulation of inner ear receptor cell differentiation(GO:2000980)
0.0	0.1	GO:1902309	negative regulation of peptidyl-serine dephosphorylation(GO:1902309)
0.0	0.1	GO:0010841	positive regulation of circadian sleep/wake cycle, wakefulness(GO:0010841)
0.0	0.1	GO:0042985	negative regulation of amyloid precursor protein biosynthetic process(GO:0042985)
0.0	0.1	GO:0070966	nuclear-transcribed mRNA catabolic process, no-go decay(GO:0070966)
0.0	0.0	GO:0003221	right ventricular cardiac muscle tissue morphogenesis(GO:0003221)
0.0	0.1	GO:1903774	positive regulation of viral budding via host ESCRT complex(GO:1903774)
0.0	0.1	GO:0032847	regulation of cellular pH reduction(GO:0032847)
0.0	0.1	GO:0090290	positive regulation of osteoclast proliferation(GO:0090290)
0.0	0.1	GO:2001260	regulation of semaphorin-plexin signaling pathway(GO:2001260)
0.0	0.2	GO:0045722	positive regulation of gluconeogenesis(GO:0045722)
0.0	0.1	GO:1902897	regulation of postsynaptic density protein 95 clustering(GO:1902897)
0.0	0.2	GO:0006415	translational termination(GO:0006415)
0.0	0.1	GO:0051835	positive regulation of synapse structural plasticity(GO:0051835)
0.0	0.1	GO:0048207	vesicle targeting, rough ER to cis-Golgi(GO:0048207) COPII vesicle coating(GO:0048208)
0.0	0.1	GO:0070189	kynurenine metabolic process(GO:0070189)
0.0	0.0	GO:0060164	regulation of timing of neuron differentiation(GO:0060164)
0.0	0.1	GO:0006477	protein sulfation(GO:0006477)
0.0	0.1	GO:0032532	regulation of microvillus length(GO:0032532)
0.0	0.1	GO:0045658	regulation of neutrophil differentiation(GO:0045658)
0.0	0.1	GO:0033211	adiponectin-activated signaling pathway(GO:0033211)
0.0	0.1	GO:0090141	positive regulation of mitochondrial fission(GO:0090141)
0.0	0.1	GO:0000290	deadenylation-dependent decapping of nuclear-transcribed mRNA(GO:0000290)
0.0	0.0	GO:0090325	regulation of locomotion involved in locomotory behavior(GO:0090325)
0.0	0.3	GO:0045187	regulation of circadian sleep/wake cycle, sleep(GO:0045187)
0.0	0.0	GO:0071504	response to heparin(GO:0071503) cellular response to heparin(GO:0071504)
0.0	0.1	GO:0002741	positive regulation of cytokine secretion involved in immune response(GO:0002741)
0.0	0.1	GO:0090091	positive regulation of extracellular matrix disassembly(GO:0090091)
0.0	0.1	GO:0006627	protein processing involved in protein targeting to mitochondrion(GO:0006627)
0.0	0.1	GO:0007638	mechanosensory behavior(GO:0007638)
0.0	0.1	GO:0035627	ceramide transport(GO:0035627)
0.0	0.0	GO:0019853	L-ascorbic acid biosynthetic process(GO:0019853)
0.0	0.0	GO:0032079	positive regulation of endodeoxyribonuclease activity(GO:0032079)
0.0	0.1	GO:0044351	macropinocytosis(GO:0044351)
0.0	0.2	GO:0090181	regulation of cholesterol metabolic process(GO:0090181)
0.0	0.1	GO:0018202	peptidyl-histidine modification(GO:0018202)
0.0	0.0	GO:0035694	mitochondrial protein catabolic process(GO:0035694)
0.0	0.0	GO:0010956	negative regulation of calcidiol 1-monooxygenase activity(GO:0010956)
0.0	0.1	GO:0007221	positive regulation of transcription of Notch receptor target(GO:0007221)
0.0	0.3	GO:0000413	protein peptidyl-prolyl isomerization(GO:0000413)
0.0	0.0	GO:0045218	zonula adherens maintenance(GO:0045218)
0.0	0.0	GO:0000050	urea cycle(GO:0000050)
0.0	0.1	GO:0033133	positive regulation of glucokinase activity(GO:0033133)
0.0	0.1	GO:0046146	tetrahydrobiopterin metabolic process(GO:0046146)
0.0	0.0	GO:2000324	positive regulation of glucocorticoid receptor signaling pathway(GO:2000324)
0.0	0.1	GO:2000210	positive regulation of anoikis(GO:2000210)
0.0	0.0	GO:0070447	positive regulation of oligodendrocyte progenitor proliferation(GO:0070447)
0.0	0.1	GO:0008355	olfactory learning(GO:0008355)
0.0	0.1	GO:0034214	protein hexamerization(GO:0034214)
0.0	0.1	GO:0060623	regulation of chromosome condensation(GO:0060623)
0.0	0.1	GO:0006517	protein deglycosylation(GO:0006517)
0.0	0.1	GO:0006407	rRNA export from nucleus(GO:0006407)
0.0	0.3	GO:0006783	heme biosynthetic process(GO:0006783)
0.0	0.0	GO:0042795	snRNA transcription from RNA polymerase II promoter(GO:0042795)
0.0	0.2	GO:0006613	cotranslational protein targeting to membrane(GO:0006613)
0.0	0.1	GO:0006689	ganglioside catabolic process(GO:0006689)
0.0	0.1	GO:0051044	positive regulation of membrane protein ectodomain proteolysis(GO:0051044)
0.0	0.0	GO:0006000	fructose metabolic process(GO:0006000)
0.0	0.1	GO:2000535	entry of bacterium into host cell(GO:0035635) regulation of entry of bacterium into host cell(GO:2000535)
0.0	0.0	GO:1900748	positive regulation of vascular endothelial growth factor signaling pathway(GO:1900748)
0.0	0.0	GO:0060167	regulation of adenosine receptor signaling pathway(GO:0060167)
0.0	0.1	GO:0015871	choline transport(GO:0015871)
0.0	0.2	GO:0070816	phosphorylation of RNA polymerase II C-terminal domain(GO:0070816)
0.0	0.1	GO:0090394	negative regulation of excitatory postsynaptic potential(GO:0090394)
0.0	0.1	GO:0015015	heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.0	0.2	GO:0008340	determination of adult lifespan(GO:0008340)
0.0	0.1	GO:0051461	positive regulation of corticotropin secretion(GO:0051461)
0.0	0.1	GO:0000712	resolution of meiotic recombination intermediates(GO:0000712)
0.0	0.0	GO:0043974	histone H3-K27 acetylation(GO:0043974) regulation of histone H3-K27 acetylation(GO:1901674)
0.0	0.0	GO:0010751	negative regulation of nitric oxide mediated signal transduction(GO:0010751)
0.0	0.1	GO:2000074	regulation of type B pancreatic cell development(GO:2000074)
0.0	0.1	GO:0090209	negative regulation of triglyceride metabolic process(GO:0090209)
0.0	0.0	GO:0032058	positive regulation of translational initiation in response to stress(GO:0032058)
0.0	0.0	GO:0016553	base conversion or substitution editing(GO:0016553)
0.0	0.1	GO:0035519	protein K29-linked ubiquitination(GO:0035519)
0.0	0.1	GO:0031581	hemidesmosome assembly(GO:0031581)
0.0	0.0	GO:1903071	positive regulation of ER-associated ubiquitin-dependent protein catabolic process(GO:1903071)
0.0	0.0	GO:0035356	cellular triglyceride homeostasis(GO:0035356)
0.0	0.0	GO:0000715	nucleotide-excision repair, DNA damage recognition(GO:0000715)
0.0	0.0	GO:2000664	positive regulation of interleukin-5 secretion(GO:2000664) positive regulation of interleukin-13 secretion(GO:2000667)
0.0	0.0	GO:0033686	positive regulation of luteinizing hormone secretion(GO:0033686)
0.0	0.0	GO:0007621	negative regulation of female receptivity(GO:0007621)
0.0	0.1	GO:0090160	Golgi to lysosome transport(GO:0090160)
0.0	0.1	GO:0032959	inositol trisphosphate biosynthetic process(GO:0032959)
0.0	0.2	GO:0051127	positive regulation of actin nucleation(GO:0051127)
0.0	0.2	GO:0008053	mitochondrial fusion(GO:0008053)
0.0	0.1	GO:0060736	prostate gland growth(GO:0060736)
0.0	0.0	GO:2000325	regulation of ligand-dependent nuclear receptor transcription coactivator activity(GO:2000325) positive regulation of ligand-dependent nuclear receptor transcription coactivator activity(GO:2000327)
0.0	0.2	GO:0019432	triglyceride biosynthetic process(GO:0019432)
0.0	0.0	GO:0048619	embryonic hindgut morphogenesis(GO:0048619)
0.0	0.0	GO:0044314	protein K27-linked ubiquitination(GO:0044314)
0.0	0.0	GO:0010510	regulation of acetyl-CoA biosynthetic process from pyruvate(GO:0010510) regulation of acyl-CoA biosynthetic process(GO:0050812)
0.0	0.2	GO:0043984	histone H4-K16 acetylation(GO:0043984)
0.0	0.1	GO:0042866	pyruvate biosynthetic process(GO:0042866)
0.0	0.0	GO:0032237	activation of store-operated calcium channel activity(GO:0032237)
0.0	0.0	GO:0010745	negative regulation of macrophage derived foam cell differentiation(GO:0010745)
0.0	0.1	GO:0006622	protein targeting to lysosome(GO:0006622)
0.0	0.0	GO:0070672	response to interleukin-15(GO:0070672)
0.0	0.1	GO:0060539	diaphragm development(GO:0060539)
0.0	0.0	GO:0043174	nucleoside salvage(GO:0043174)
0.0	0.1	GO:0043249	erythrocyte maturation(GO:0043249)
0.0	0.0	GO:0042891	antibiotic transport(GO:0042891)
0.0	0.1	GO:0006607	NLS-bearing protein import into nucleus(GO:0006607)
0.0	0.0	GO:0014891	striated muscle atrophy(GO:0014891)
0.0	0.2	GO:2000785	regulation of autophagosome assembly(GO:2000785)
0.0	0.1	GO:0035025	positive regulation of Rho protein signal transduction(GO:0035025)
0.0	0.1	GO:2000653	regulation of genetic imprinting(GO:2000653)
0.0	0.0	GO:1901874	regulation of post-translational protein modification(GO:1901873) negative regulation of post-translational protein modification(GO:1901874)
0.0	0.0	GO:1902548	negative regulation of cellular response to vascular endothelial growth factor stimulus(GO:1902548)
0.0	0.0	GO:0071947	protein deubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0071947)
0.0	0.0	GO:0090148	membrane fission(GO:0090148)
0.0	0.1	GO:0018231	peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
0.0	0.1	GO:0070050	neuron cellular homeostasis(GO:0070050)
0.0	0.1	GO:0022615	protein to membrane docking(GO:0022615)
0.0	0.0	GO:0034773	histone H4-K20 trimethylation(GO:0034773)
0.0	0.1	GO:0006370	7-methylguanosine mRNA capping(GO:0006370)
0.0	0.0	GO:0071732	cellular response to nitric oxide(GO:0071732)
0.0	0.0	GO:0006543	glutamine catabolic process(GO:0006543)
0.0	0.0	GO:0042524	negative regulation of tyrosine phosphorylation of Stat5 protein(GO:0042524)
0.0	0.0	GO:0071447	cellular response to hydroperoxide(GO:0071447)
0.0	0.1	GO:0031468	nuclear envelope reassembly(GO:0031468)
0.0	0.0	GO:0002051	osteoblast fate commitment(GO:0002051)
0.0	0.1	GO:0051694	pointed-end actin filament capping(GO:0051694)
0.0	0.0	GO:0006083	acetate metabolic process(GO:0006083)
0.0	0.0	GO:0010360	negative regulation of anion channel activity(GO:0010360)
0.0	0.1	GO:0022027	interkinetic nuclear migration(GO:0022027)
0.0	0.1	GO:0051152	positive regulation of smooth muscle cell differentiation(GO:0051152)
0.0	0.1	GO:0031053	primary miRNA processing(GO:0031053)
0.0	0.0	GO:0061589	calcium activated phosphatidylserine scrambling(GO:0061589)
0.0	0.1	GO:0006590	thyroid hormone generation(GO:0006590)
0.0	0.0	GO:0070777	D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
0.0	0.1	GO:0033262	regulation of nuclear cell cycle DNA replication(GO:0033262)
0.0	0.0	GO:0010248	establishment or maintenance of transmembrane electrochemical gradient(GO:0010248)
0.0	0.1	GO:0055064	chloride ion homeostasis(GO:0055064)
0.0	0.1	GO:0051255	mitotic spindle elongation(GO:0000022) spindle midzone assembly(GO:0051255) mitotic spindle midzone assembly(GO:0051256)
0.0	0.0	GO:0010040	response to iron(II) ion(GO:0010040)
0.0	0.0	GO:2000002	negative regulation of DNA damage checkpoint(GO:2000002)
0.0	0.1	GO:0043278	response to isoquinoline alkaloid(GO:0014072) response to morphine(GO:0043278)
0.0	0.0	GO:0043321	regulation of natural killer cell degranulation(GO:0043321)
0.0	0.2	GO:0018345	protein palmitoylation(GO:0018345)
0.0	0.0	GO:0070125	mitochondrial translational elongation(GO:0070125)
0.0	0.1	GO:0045056	transcytosis(GO:0045056)
0.0	0.0	GO:1904491	protein localization to ciliary transition zone(GO:1904491)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	0.6	GO:0097487	multivesicular body, internal vesicle(GO:0097487)
0.1	0.5	GO:0042824	MHC class I peptide loading complex(GO:0042824)
0.1	0.3	GO:0031088	platelet dense granule membrane(GO:0031088)
0.1	0.3	GO:0031315	extrinsic component of mitochondrial outer membrane(GO:0031315)
0.1	0.6	GO:0070852	cell body fiber(GO:0070852)
0.1	0.2	GO:0044316	cone cell pedicle(GO:0044316)
0.0	0.2	GO:1990712	HFE-transferrin receptor complex(GO:1990712)
0.0	0.2	GO:0035363	histone locus body(GO:0035363)
0.0	0.2	GO:0070545	PeBoW complex(GO:0070545)
0.0	0.1	GO:0002142	stereocilia ankle link complex(GO:0002142)
0.0	0.2	GO:0031094	platelet dense tubular network(GO:0031094)
0.0	0.1	GO:0035985	senescence-associated heterochromatin focus(GO:0035985)
0.0	0.2	GO:0070695	FHF complex(GO:0070695)
0.0	0.4	GO:0030061	mitochondrial crista(GO:0030061)
0.0	0.3	GO:0045275	mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275)
0.0	0.1	GO:0032541	cortical endoplasmic reticulum(GO:0032541)
0.0	0.4	GO:0032426	stereocilium tip(GO:0032426)
0.0	0.1	GO:0031265	CD95 death-inducing signaling complex(GO:0031265)
0.0	0.0	GO:0002141	stereocilia ankle link(GO:0002141) USH2 complex(GO:1990696)
0.0	0.1	GO:0044530	supraspliceosomal complex(GO:0044530)
0.0	0.1	GO:0031258	lamellipodium membrane(GO:0031258)
0.0	0.3	GO:0036513	Derlin-1 retrotranslocation complex(GO:0036513)
0.0	0.1	GO:0043527	tRNA methyltransferase complex(GO:0043527)
0.0	0.4	GO:0043240	Fanconi anaemia nuclear complex(GO:0043240)
0.0	0.1	GO:0097451	glial limiting end-foot(GO:0097451)
0.0	0.1	GO:0008275	gamma-tubulin small complex(GO:0008275)
0.0	0.2	GO:0005915	zonula adherens(GO:0005915)
0.0	0.3	GO:0005847	mRNA cleavage and polyadenylation specificity factor complex(GO:0005847)
0.0	0.5	GO:0005942	phosphatidylinositol 3-kinase complex(GO:0005942)
0.0	0.1	GO:0035867	alphav-beta3 integrin-IGF-1-IGF1R complex(GO:0035867)
0.0	0.2	GO:0016272	prefoldin complex(GO:0016272)
0.0	0.2	GO:0005952	cAMP-dependent protein kinase complex(GO:0005952)
0.0	0.0	GO:0032127	dense core granule membrane(GO:0032127)
0.0	0.1	GO:0032021	NELF complex(GO:0032021)
0.0	0.1	GO:0034388	Pwp2p-containing subcomplex of 90S preribosome(GO:0034388)
0.0	0.1	GO:0044615	nuclear pore nuclear basket(GO:0044615)
0.0	0.1	GO:0000408	EKC/KEOPS complex(GO:0000408)
0.0	0.1	GO:0072487	MSL complex(GO:0072487)
0.0	0.1	GO:0097149	centralspindlin complex(GO:0097149)
0.0	0.2	GO:0033116	endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116)
0.0	0.1	GO:0005964	phosphorylase kinase complex(GO:0005964)
0.0	0.1	GO:0031074	nucleocytoplasmic shuttling complex(GO:0031074)
0.0	0.2	GO:0000930	gamma-tubulin complex(GO:0000930)
0.0	0.2	GO:0001891	phagocytic cup(GO:0001891)
0.0	0.2	GO:0046930	pore complex(GO:0046930)
0.0	0.1	GO:0045098	type III intermediate filament(GO:0045098)
0.0	0.2	GO:0046581	intercellular canaliculus(GO:0046581)
0.0	0.3	GO:0002102	podosome(GO:0002102)
0.0	0.1	GO:0032009	early phagosome(GO:0032009)
0.0	0.1	GO:0000815	ESCRT III complex(GO:0000815)
0.0	0.1	GO:0043159	acrosomal matrix(GO:0043159)
0.0	0.1	GO:0033269	internode region of axon(GO:0033269)
0.0	0.0	GO:0005827	polar microtubule(GO:0005827)
0.0	0.1	GO:0016461	unconventional myosin complex(GO:0016461)
0.0	0.1	GO:0098554	cytoplasmic side of endoplasmic reticulum membrane(GO:0098554)
0.0	0.1	GO:0036056	filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.0	0.1	GO:0070044	synaptobrevin 2-SNAP-25-syntaxin-1a complex(GO:0070044)
0.0	0.1	GO:0090571	RNA polymerase II transcription repressor complex(GO:0090571)
0.0	0.1	GO:0031262	Ndc80 complex(GO:0031262)
0.0	0.1	GO:0001940	male pronucleus(GO:0001940)
0.0	0.0	GO:0060053	neurofilament cytoskeleton(GO:0060053)
0.0	0.2	GO:0005671	Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)
0.0	0.0	GO:0071942	XPC complex(GO:0071942)
0.0	0.1	GO:0044300	cerebellar mossy fiber(GO:0044300)
0.0	0.1	GO:0000445	THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445)
0.0	0.1	GO:0033391	chromatoid body(GO:0033391)
0.0	0.1	GO:0005845	mRNA cap binding complex(GO:0005845) RNA cap binding complex(GO:0034518)
0.0	0.0	GO:1990635	proximal dendrite(GO:1990635)
0.0	0.0	GO:0097025	MPP7-DLG1-LIN7 complex(GO:0097025)
0.0	0.0	GO:0045293	mRNA editing complex(GO:0045293)
0.0	0.1	GO:0000220	vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220)
0.0	0.0	GO:0097433	dense body(GO:0097433)
0.0	0.1	GO:0005851	eukaryotic translation initiation factor 2B complex(GO:0005851)
0.0	0.1	GO:0071541	eukaryotic translation initiation factor 3 complex, eIF3m(GO:0071541)
0.0	0.0	GO:0072534	perineuronal net(GO:0072534)
0.0	0.2	GO:0032588	trans-Golgi network membrane(GO:0032588)
0.0	0.1	GO:0031314	extrinsic component of mitochondrial inner membrane(GO:0031314)
0.0	0.1	GO:0005916	fascia adherens(GO:0005916)
0.0	0.1	GO:0036128	CatSper complex(GO:0036128)
0.0	0.1	GO:0035749	myelin sheath adaxonal region(GO:0035749)
0.0	0.0	GO:0043202	lysosomal lumen(GO:0043202)
0.0	0.1	GO:0072357	PTW/PP1 phosphatase complex(GO:0072357)
0.0	0.0	GO:0071203	WASH complex(GO:0071203)
0.0	0.1	GO:0001527	microfibril(GO:0001527)
0.0	0.1	GO:0030877	beta-catenin destruction complex(GO:0030877)
0.0	0.1	GO:0070820	tertiary granule(GO:0070820)
0.0	0.2	GO:0070971	endoplasmic reticulum exit site(GO:0070971)
0.0	0.1	GO:0097038	perinuclear endoplasmic reticulum(GO:0097038)
0.0	0.0	GO:0033647	host intracellular organelle(GO:0033647) host intracellular membrane-bounded organelle(GO:0033648)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	0.6	GO:0005006	epidermal growth factor-activated receptor activity(GO:0005006)
0.2	1.0	GO:0047760	butyrate-CoA ligase activity(GO:0047760)
0.2	0.5	GO:0004886	9-cis retinoic acid receptor activity(GO:0004886)
0.1	0.4	GO:0070538	oleic acid binding(GO:0070538)
0.1	0.4	GO:0030160	GKAP/Homer scaffold activity(GO:0030160)
0.1	0.5	GO:0009374	biotin binding(GO:0009374)
0.1	0.3	GO:0038181	bile acid receptor activity(GO:0038181)
0.1	0.3	GO:0004427	inorganic diphosphatase activity(GO:0004427)
0.1	0.3	GO:0003986	acetyl-CoA hydrolase activity(GO:0003986)
0.1	0.7	GO:0003836	beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.1	0.3	GO:0004771	sterol esterase activity(GO:0004771)
0.1	0.3	GO:0032896	palmitoyl-CoA 9-desaturase activity(GO:0032896)
0.1	0.2	GO:0043125	ErbB-3 class receptor binding(GO:0043125)
0.1	0.3	GO:0004035	alkaline phosphatase activity(GO:0004035)
0.1	0.1	GO:0004768	stearoyl-CoA 9-desaturase activity(GO:0004768)
0.1	0.2	GO:0071614	linoleic acid epoxygenase activity(GO:0071614)
0.1	0.2	GO:0005220	inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.1	0.1	GO:0036042	long-chain fatty acyl-CoA binding(GO:0036042)
0.1	0.2	GO:0004366	glycerol-3-phosphate O-acyltransferase activity(GO:0004366)
0.1	0.5	GO:0004499	N,N-dimethylaniline monooxygenase activity(GO:0004499)
0.1	0.2	GO:0016743	carboxyl- or carbamoyltransferase activity(GO:0016743)
0.1	0.2	GO:0031686	A1 adenosine receptor binding(GO:0031686)
0.0	0.1	GO:0004924	oncostatin-M receptor activity(GO:0004924)
0.0	0.1	GO:0019153	protein-disulfide reductase (glutathione) activity(GO:0019153)
0.0	0.6	GO:0015643	toxic substance binding(GO:0015643)
0.0	0.1	GO:0008310	single-stranded DNA 3'-5' exodeoxyribonuclease activity(GO:0008310)
0.0	0.1	GO:0004949	cannabinoid receptor activity(GO:0004949)
0.0	0.2	GO:0016744	transferase activity, transferring aldehyde or ketonic groups(GO:0016744)
0.0	0.8	GO:0003785	actin monomer binding(GO:0003785)
0.0	0.1	GO:0000405	bubble DNA binding(GO:0000405)
0.0	0.2	GO:0030284	estrogen receptor activity(GO:0030284)
0.0	0.1	GO:0047074	2,3-dihydroxy DDT 1,2-dioxygenase activity(GO:0018542) phenanthrene dioxygenase activity(GO:0018555) 2,2',3-trihydroxybiphenyl dioxygenase activity(GO:0018556) 1,2-dihydroxyfluorene 1,1-alpha-dioxygenase activity(GO:0018557) 5,6-dihydroxy-3-methyl-2-oxo-1,2-dihydroquinoline dioxygenase activity(GO:0018558) 1,1-dichloro-2-(dihydroxy-4-chlorophenyl)-(4-chlorophenyl)ethene 1,2-dioxygenase activity(GO:0018559) protocatechuate 3,4-dioxygenase type II activity(GO:0018560) 2'-aminobiphenyl-2,3-diol 1,2-dioxygenase activity(GO:0018561) 3,4-dihydroxyfluorene 4,4-alpha-dioxygenase activity(GO:0018562) 2,3-dihydroxy-ethylbenzene 1,2-dioxygenase activity(GO:0018563) carbazole 1,9a-dioxygenase activity(GO:0018564) dihydroxydibenzothiophene dioxygenase activity(GO:0018565) 1,2-dihydroxynaphthalene-6-sulfonate 1,8a-dioxygenase activity(GO:0018566) styrene dioxygenase activity(GO:0018567) 3,4-dihydroxyphenanthrene dioxygenase activity(GO:0018568) hydroquinone 1,2-dioxygenase activity(GO:0018569) p-cumate 2,3-dioxygenase activity(GO:0018570) 2,3-dihydroxy-p-cumate dioxygenase activity(GO:0018571) 3,5-dichlorocatechol 1,2-dioxygenase activity(GO:0018572) 2-aminophenol 1,6-dioxygenase activity(GO:0018573) 2,6-dichloro-p-hydroquinone 1,2-dioxygenase activity(GO:0018574) chlorocatechol 1,2-dioxygenase activity(GO:0018575) catechol dioxygenase activity(GO:0019114) dihydroxyfluorene dioxygenase activity(GO:0019117) 5-aminosalicylate dioxygenase activity(GO:0034543) 3-hydroxy-2-naphthoate 2,3-dioxygenase activity(GO:0034803) benzo(a)pyrene 11,12-dioxygenase activity(GO:0034806) benzo(a)pyrene 4,5-dioxygenase activity(GO:0034808) 4,5-dihydroxybenzo(a)pyrene dioxygenase activity(GO:0034810) benzo(a)pyrene 9,10-dioxygenase activity(GO:0034811) 9,10-dihydroxybenzo(a)pyrene dioxygenase activity(GO:0034812) benzo(a)pyrene 7,8-dioxygenase activity(GO:0034813) 7,8-dihydroxy benzo(a)pyrene dioxygenase activity(GO:0034814) 1,2-dihydroxy-5,6,7,8-tetrahydronaphthalene extradiol dioxygenase activity(GO:0034827) 2-mercaptobenzothiazole dioxygenase activity(GO:0034834) pyridine-3,4-diol dioxygenase activity(GO:0034895) pyrene dioxygenase activity(GO:0034920) 4,5-dihydroxypyrene dioxygenase activity(GO:0034922) phenanthrene-4-carboxylate dioxygenase activity(GO:0034934) tetrachlorobenzene dioxygenase activity(GO:0034935) 4,6-dichloro-3-methylcatechol 1,2-dioxygenase activity(GO:0034936) 2,3-dihydroxydiphenyl ether dioxygenase activity(GO:0034955) diphenyl ether 1,2-dioxygenase activity(GO:0034956) arachidonate 8(S)-lipoxygenase activity(GO:0036403) 4-hydroxycatechol 1,2-dioxygenase activity(GO:0047074)
0.0	0.3	GO:0005167	neurotrophin TRK receptor binding(GO:0005167)
0.0	0.1	GO:0004013	adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.0	0.2	GO:0033300	dehydroascorbic acid transporter activity(GO:0033300)
0.0	0.1	GO:0004075	biotin carboxylase activity(GO:0004075)
0.0	0.2	GO:0015288	porin activity(GO:0015288)
0.0	0.2	GO:0046624	sphingolipid transporter activity(GO:0046624)
0.0	0.1	GO:0046976	histone methyltransferase activity (H3-K27 specific)(GO:0046976)
0.0	0.1	GO:0070548	L-glutamine aminotransferase activity(GO:0070548)
0.0	0.3	GO:0016888	endodeoxyribonuclease activity, producing 5'-phosphomonoesters(GO:0016888)
0.0	0.1	GO:0003726	double-stranded RNA adenosine deaminase activity(GO:0003726)
0.0	0.1	GO:0050252	retinol O-fatty-acyltransferase activity(GO:0050252)
0.0	0.2	GO:0008079	translation release factor activity(GO:0003747) translation termination factor activity(GO:0008079)
0.0	0.1	GO:0097200	cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:0097200)
0.0	0.1	GO:0030911	TPR domain binding(GO:0030911)
0.0	0.4	GO:0008195	phosphatidate phosphatase activity(GO:0008195)
0.0	0.1	GO:0005483	soluble NSF attachment protein activity(GO:0005483)
0.0	0.2	GO:0004679	AMP-activated protein kinase activity(GO:0004679)
0.0	0.2	GO:0017040	ceramidase activity(GO:0017040)
0.0	0.4	GO:0001972	retinoic acid binding(GO:0001972)
0.0	0.1	GO:0050833	pyruvate transmembrane transporter activity(GO:0050833)
0.0	0.1	GO:0004887	thyroid hormone receptor activity(GO:0004887)
0.0	0.0	GO:0043849	Ras palmitoyltransferase activity(GO:0043849)
0.0	0.1	GO:0035276	ethanol binding(GO:0035276)
0.0	0.2	GO:0030346	protein phosphatase 2B binding(GO:0030346)
0.0	0.1	GO:0097493	structural molecule activity conferring elasticity(GO:0097493)
0.0	0.2	GO:0038036	sphingosine-1-phosphate receptor activity(GO:0038036)
0.0	0.2	GO:0031749	D2 dopamine receptor binding(GO:0031749)
0.0	0.1	GO:0031802	type 5 metabotropic glutamate receptor binding(GO:0031802)
0.0	0.1	GO:0035662	Toll-like receptor 4 binding(GO:0035662)
0.0	0.1	GO:0003831	beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity(GO:0003831)
0.0	0.1	GO:0008467	[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity(GO:0008467)
0.0	0.2	GO:0008131	primary amine oxidase activity(GO:0008131)
0.0	0.1	GO:0097109	neuroligin family protein binding(GO:0097109)
0.0	0.0	GO:0008603	cAMP-dependent protein kinase regulator activity(GO:0008603)
0.0	0.1	GO:0016997	exo-alpha-sialidase activity(GO:0004308) alpha-sialidase activity(GO:0016997) exo-alpha-(2->3)-sialidase activity(GO:0052794) exo-alpha-(2->6)-sialidase activity(GO:0052795) exo-alpha-(2->8)-sialidase activity(GO:0052796)
0.0	0.4	GO:0005528	macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.0	0.1	GO:0034186	apolipoprotein A-I binding(GO:0034186)
0.0	0.0	GO:0016015	morphogen activity(GO:0016015)
0.0	0.1	GO:0004859	phospholipase inhibitor activity(GO:0004859)
0.0	0.1	GO:0004332	fructose-bisphosphate aldolase activity(GO:0004332)
0.0	0.1	GO:0031781	melanocortin receptor binding(GO:0031779) type 3 melanocortin receptor binding(GO:0031781) type 4 melanocortin receptor binding(GO:0031782)
0.0	0.1	GO:0005047	signal recognition particle binding(GO:0005047)
0.0	0.0	GO:0016418	S-acetyltransferase activity(GO:0016418)
0.0	0.6	GO:0070330	aromatase activity(GO:0070330)
0.0	0.1	GO:0097371	MDM2/MDM4 family protein binding(GO:0097371)
0.0	0.0	GO:0032767	copper-dependent protein binding(GO:0032767)
0.0	0.1	GO:0035005	1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.0	0.1	GO:0008515	sucrose:proton symporter activity(GO:0008506) sucrose transmembrane transporter activity(GO:0008515) disaccharide transmembrane transporter activity(GO:0015154) oligosaccharide transmembrane transporter activity(GO:0015157)
0.0	0.1	GO:0035197	siRNA binding(GO:0035197)
0.0	0.1	GO:0035033	histone deacetylase regulator activity(GO:0035033)
0.0	0.1	GO:0017151	DEAD/H-box RNA helicase binding(GO:0017151)
0.0	0.3	GO:0030955	potassium ion binding(GO:0030955)
0.0	0.4	GO:0030552	cAMP binding(GO:0030552)
0.0	0.1	GO:0070573	metallodipeptidase activity(GO:0070573)
0.0	0.1	GO:0016151	nickel cation binding(GO:0016151)
0.0	0.0	GO:1990825	sequence-specific mRNA binding(GO:1990825)
0.0	0.1	GO:0016520	growth hormone-releasing hormone receptor activity(GO:0016520)
0.0	0.1	GO:0015183	L-aspartate transmembrane transporter activity(GO:0015183)
0.0	0.1	GO:0005381	iron ion transmembrane transporter activity(GO:0005381)
0.0	0.1	GO:0004689	phosphorylase kinase activity(GO:0004689)
0.0	0.0	GO:1990239	steroid hormone binding(GO:1990239)
0.0	0.1	GO:0050321	tau-protein kinase activity(GO:0050321)
0.0	0.1	GO:0043515	kinetochore binding(GO:0043515)
0.0	0.1	GO:0055100	adiponectin binding(GO:0055100)
0.0	0.1	GO:0005007	fibroblast growth factor-activated receptor activity(GO:0005007)
0.0	0.1	GO:0043426	MRF binding(GO:0043426)
0.0	0.1	GO:0004096	catalase activity(GO:0004096)
0.0	0.6	GO:0016749	N-succinyltransferase activity(GO:0016749)
0.0	0.3	GO:0004708	MAP kinase kinase activity(GO:0004708)
0.0	0.2	GO:0070569	uridylyltransferase activity(GO:0070569)
0.0	0.1	GO:0004908	interleukin-1 receptor activity(GO:0004908)
0.0	0.1	GO:0036374	gamma-glutamyltransferase activity(GO:0003840) glutathione hydrolase activity(GO:0036374)
0.0	0.1	GO:0047105	aminobutyraldehyde dehydrogenase activity(GO:0019145) 4-trimethylammoniobutyraldehyde dehydrogenase activity(GO:0047105)
0.0	0.1	GO:0051022	Rho GDP-dissociation inhibitor binding(GO:0051022)
0.0	0.1	GO:0016215	acyl-CoA desaturase activity(GO:0016215)
0.0	0.5	GO:0018731	prenylcysteine methylesterase activity(GO:0010296) 1-oxa-2-oxocycloheptane lactonase activity(GO:0018731) sulfolactone hydrolase activity(GO:0018732) butyrolactone hydrolase activity(GO:0018734) endosulfan lactone lactonase activity(GO:0034892) L-ascorbate 6-phosphate lactonase activity(GO:0035460) Ser-tRNA(Thr) hydrolase activity(GO:0043905) Ala-tRNA(Pro) hydrolase activity(GO:0043906) Cys-tRNA(Pro) hydrolase activity(GO:0043907) Ser(Gly)-tRNA(Ala) hydrolase activity(GO:0043908) all-trans-retinyl-palmitate hydrolase, all-trans-retinol forming activity(GO:0047376) mannosyl-oligosaccharide 1,6-alpha-mannosidase activity(GO:0052767) mannosyl-oligosaccharide 1,3-alpha-mannosidase activity(GO:0052768) methyl indole-3-acetate esterase activity(GO:0080030) methyl salicylate esterase activity(GO:0080031) methyl jasmonate esterase activity(GO:0080032)
0.0	0.1	GO:1904288	BAT3 complex binding(GO:1904288)
0.0	0.3	GO:0008139	nuclear localization sequence binding(GO:0008139)
0.0	0.0	GO:0004849	uridine kinase activity(GO:0004849)
0.0	0.0	GO:0016748	succinyltransferase activity(GO:0016748)
0.0	0.2	GO:0008331	high voltage-gated calcium channel activity(GO:0008331)
0.0	0.3	GO:0050136	NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0	0.3	GO:0004683	calmodulin-dependent protein kinase activity(GO:0004683)
0.0	0.1	GO:0004994	somatostatin receptor activity(GO:0004994)
0.0	0.0	GO:0016842	amidine-lyase activity(GO:0016842)
0.0	0.1	GO:0038132	neuregulin binding(GO:0038132)
0.0	0.2	GO:0017128	phospholipid scramblase activity(GO:0017128)
0.0	0.1	GO:0004090	carbonyl reductase (NADPH) activity(GO:0004090)
0.0	0.1	GO:0046972	histone acetyltransferase activity (H4-K5 specific)(GO:0043995) histone acetyltransferase activity (H4-K8 specific)(GO:0043996) histone acetyltransferase activity (H4-K16 specific)(GO:0046972)
0.0	0.1	GO:0016661	oxidoreductase activity, acting on other nitrogenous compounds as donors(GO:0016661)
0.0	0.0	GO:0004416	hydroxyacylglutathione hydrolase activity(GO:0004416)
0.0	0.1	GO:0004060	arylamine N-acetyltransferase activity(GO:0004060)
0.0	0.1	GO:0004566	beta-glucuronidase activity(GO:0004566)
0.0	0.1	GO:0070878	primary miRNA binding(GO:0070878)
0.0	0.1	GO:0004865	protein serine/threonine phosphatase inhibitor activity(GO:0004865)
0.0	0.1	GO:0004614	phosphoglucomutase activity(GO:0004614)
0.0	0.0	GO:0070698	type I activin receptor binding(GO:0070698)
0.0	0.1	GO:0004385	guanylate kinase activity(GO:0004385)
0.0	0.1	GO:0036122	BMP binding(GO:0036122)
0.0	0.2	GO:0004089	carbonate dehydratase activity(GO:0004089)
0.0	0.2	GO:0008353	RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353)
0.0	0.1	GO:0004694	eukaryotic translation initiation factor 2alpha kinase activity(GO:0004694)
0.0	0.0	GO:0097001	ceramide binding(GO:0097001)
0.0	0.3	GO:0016645	oxidoreductase activity, acting on the CH-NH group of donors(GO:0016645)
0.0	0.2	GO:0070006	metalloaminopeptidase activity(GO:0070006)
0.0	0.0	GO:0004505	phenylalanine 4-monooxygenase activity(GO:0004505)
0.0	0.1	GO:0050072	m7G(5')pppN diphosphatase activity(GO:0050072)
0.0	0.1	GO:0046848	hydroxyapatite binding(GO:0046848)
0.0	0.1	GO:0015220	choline transmembrane transporter activity(GO:0015220)
0.0	0.1	GO:0009378	four-way junction helicase activity(GO:0009378)
0.0	0.1	GO:1900750	glutathione binding(GO:0043295) oligopeptide binding(GO:1900750)
0.0	0.1	GO:0050291	sphingosine N-acyltransferase activity(GO:0050291)
0.0	0.2	GO:0008607	phosphorylase kinase regulator activity(GO:0008607)
0.0	0.1	GO:0061505	DNA topoisomerase type II (ATP-hydrolyzing) activity(GO:0003918) DNA topoisomerase II activity(GO:0061505)
0.0	0.1	GO:0031419	cobalamin binding(GO:0031419)
0.0	0.4	GO:0004364	glutathione transferase activity(GO:0004364)
0.0	0.0	GO:0019976	interleukin-2 binding(GO:0019976)
0.0	0.0	GO:0042895	antibiotic transporter activity(GO:0042895)
0.0	0.1	GO:0016500	protein-hormone receptor activity(GO:0016500)
0.0	0.0	GO:0017116	single-stranded DNA-dependent ATP-dependent DNA helicase activity(GO:0017116)
0.0	0.3	GO:0051721	protein phosphatase 2A binding(GO:0051721)
0.0	0.0	GO:0016714	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen(GO:0016714)
0.0	0.0	GO:0008948	oxaloacetate decarboxylase activity(GO:0008948)
0.0	0.0	GO:0004741	[pyruvate dehydrogenase (lipoamide)] phosphatase activity(GO:0004741)
0.0	0.1	GO:0010861	thyroid hormone receptor activator activity(GO:0010861)
0.0	0.0	GO:0001591	dopamine neurotransmitter receptor activity, coupled via Gi/Go(GO:0001591)
0.0	0.2	GO:0008409	5'-3' exonuclease activity(GO:0008409)
0.0	0.2	GO:0031434	mitogen-activated protein kinase kinase binding(GO:0031434)
0.0	0.0	GO:0055131	C3HC4-type RING finger domain binding(GO:0055131)
0.0	0.1	GO:0008420	CTD phosphatase activity(GO:0008420)
0.0	0.0	GO:0051032	nucleic acid transmembrane transporter activity(GO:0051032) RNA transmembrane transporter activity(GO:0051033)
0.0	0.0	GO:0031893	vasopressin receptor binding(GO:0031893)
0.0	0.1	GO:0000339	RNA cap binding(GO:0000339)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	1.4	PID RXR VDR PATHWAY	RXR and RAR heterodimerization with other nuclear receptor
0.1	0.1	PID ER NONGENOMIC PATHWAY	Plasma membrane estrogen receptor signaling
0.0	0.6	PID ERBB NETWORK PATHWAY	ErbB receptor signaling network
0.0	0.3	PID S1P S1P4 PATHWAY	S1P4 pathway
0.0	0.8	ST TUMOR NECROSIS FACTOR PATHWAY	Tumor Necrosis Factor Pathway.
0.0	0.3	PID TRAIL PATHWAY	TRAIL signaling pathway
0.0	0.2	PID RANBP2 PATHWAY	Sumoylation by RanBP2 regulates transcriptional repression
0.0	0.1	PID MAPK TRK PATHWAY	Trk receptor signaling mediated by the MAPK pathway
0.0	0.9	PID HEDGEHOG GLI PATHWAY	Hedgehog signaling events mediated by Gli proteins
0.0	0.1	ST PAC1 RECEPTOR PATHWAY	PAC1 Receptor Pathway
0.0	0.1	PID AR NONGENOMIC PATHWAY	Nongenotropic Androgen signaling
0.0	0.1	ST JAK STAT PATHWAY	Jak-STAT Pathway
0.0	0.2	PID HIF1A PATHWAY	Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.0	0.1	SIG PIP3 SIGNALING IN CARDIAC MYOCTES	Genes related to PIP3 signaling in cardiac myocytes
0.0	0.1	PID TCR RAS PATHWAY	Ras signaling in the CD4+ TCR pathway
0.0	0.2	ST GAQ PATHWAY	G alpha q Pathway
0.0	0.0	PID IL8 CXCR1 PATHWAY	IL8- and CXCR1-mediated signaling events
0.0	0.1	PID ALK2 PATHWAY	ALK2 signaling events
0.0	0.1	PID CIRCADIAN PATHWAY	Circadian rhythm pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.1	REACTOME ERK MAPK TARGETS	Genes involved in ERK/MAPK targets
0.1	0.3	REACTOME IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION	Genes involved in IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
0.0	0.8	REACTOME SIGNALING BY CONSTITUTIVELY ACTIVE EGFR	Genes involved in Signaling by constitutively active EGFR
0.0	0.1	REACTOME ALPHA LINOLENIC ACID ALA METABOLISM	Genes involved in alpha-linolenic acid (ALA) metabolism
0.0	0.4	REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA	Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.0	0.6	REACTOME PRE NOTCH PROCESSING IN GOLGI	Genes involved in Pre-NOTCH Processing in Golgi
0.0	0.7	REACTOME RORA ACTIVATES CIRCADIAN EXPRESSION	Genes involved in RORA Activates Circadian Expression
0.0	0.4	REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA HYDROXYCHOLESTEROL	Genes involved in Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
0.0	0.7	REACTOME GLUTATHIONE CONJUGATION	Genes involved in Glutathione conjugation
0.0	0.3	REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK	Genes involved in Regulation of Rheb GTPase activity by AMPK
0.0	0.4	REACTOME METABOLISM OF PORPHYRINS	Genes involved in Metabolism of porphyrins
0.0	0.0	REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE	Genes involved in mRNA Decay by 3' to 5' Exoribonuclease
0.0	0.1	REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS	Genes involved in Synthesis of bile acids and bile salts
0.0	0.2	REACTOME PROLACTIN RECEPTOR SIGNALING	Genes involved in Prolactin receptor signaling
0.0	0.4	REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS	Genes involved in Regulation of gene expression in beta cells
0.0	0.1	REACTOME INFLUENZA VIRAL RNA TRANSCRIPTION AND REPLICATION	Genes involved in Influenza Viral RNA Transcription and Replication
0.0	0.4	REACTOME FANCONI ANEMIA PATHWAY	Genes involved in Fanconi Anemia pathway
0.0	0.7	REACTOME TRIGLYCERIDE BIOSYNTHESIS	Genes involved in Triglyceride Biosynthesis
0.0	0.2	REACTOME REGULATION OF COMPLEMENT CASCADE	Genes involved in Regulation of Complement cascade
0.0	0.2	REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC	Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.0	0.1	REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING	Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.0	0.2	REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS	Genes involved in Glycogen breakdown (glycogenolysis)
0.0	0.3	REACTOME DARPP 32 EVENTS	Genes involved in DARPP-32 events
0.0	0.1	REACTOME ABACAVIR TRANSPORT AND METABOLISM	Genes involved in Abacavir transport and metabolism
0.0	0.2	REACTOME RAP1 SIGNALLING	Genes involved in Rap1 signalling
0.0	0.2	REACTOME DESTABILIZATION OF MRNA BY TRISTETRAPROLIN TTP	Genes involved in Destabilization of mRNA by Tristetraprolin (TTP)
0.0	0.1	REACTOME TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING	Genes involved in TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
0.0	0.3	REACTOME MITOCHONDRIAL TRNA AMINOACYLATION	Genes involved in Mitochondrial tRNA aminoacylation
0.0	0.5	REACTOME PHASE1 FUNCTIONALIZATION OF COMPOUNDS	Genes involved in Phase 1 - Functionalization of compounds
0.0	0.0	REACTOME GROWTH HORMONE RECEPTOR SIGNALING	Genes involved in Growth hormone receptor signaling
0.0	0.1	REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS	Genes involved in Extrinsic Pathway for Apoptosis
0.0	0.2	REACTOME IL RECEPTOR SHC SIGNALING	Genes involved in Interleukin receptor SHC signaling
0.0	0.2	REACTOME NONSENSE MEDIATED DECAY ENHANCED BY THE EXON JUNCTION COMPLEX	Genes involved in Nonsense Mediated Decay Enhanced by the Exon Junction Complex
0.0	0.1	REACTOME DSCAM INTERACTIONS	Genes involved in DSCAM interactions
0.0	0.3	REACTOME PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC	Genes involved in Prefoldin mediated transfer of substrate to CCT/TriC
0.0	0.2	REACTOME SIGNALING BY BMP	Genes involved in Signaling by BMP
0.0	0.1	REACTOME TRYPTOPHAN CATABOLISM	Genes involved in Tryptophan catabolism

Results for Smad4

Z-value: 1.60

Motif logo

Transcription factors associated with Smad4

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

Activity of the Smad4 motif across conditions

Conditions sorted by the z-value of the Smad4 motif activity

Top target CREs of the motif:

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of Smad4

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: