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ENCSR904DTN: DNase-seq of mouse liver in constant darkness

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for Sox13

Z-value: 1.05

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Transcription factors associated with Sox13

Gene Symbol	Gene ID	Gene Info
Sox13 Ensembl NCBI MGI UniProt	ENSMUSG00000070643.5	Sox13

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

Gene	Promoter	Distance	Association probability	Pearson corr. coef.	P-value	Plot
Sox13	chr1_133379266_133379589	6099	0.151951	0.83	4.0e-02	Click!
Sox13	chr1_133424091_133424476	94	0.970159	-0.79	6.0e-02	Click!
Sox13	chr1_133382772_133383217	2532	0.220978	0.72	1.0e-01	Click!
Sox13	chr1_133452165_133452316	27863	0.158634	0.60	2.0e-01	Click!
Sox13	chr1_133382391_133382543	3059	0.197220	0.60	2.0e-01	Click!

Activity of the Sox13 motif across conditions

Conditions sorted by the z-value of the Sox13 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr12_25303768_25303919	0.40	Gm36723	predicted gene, 36723	97	0.92
chr19_17554976_17555127	0.26	Gm17819	predicted gene, 17819	137712	0.05
chr18_43966502_43966653	0.26	Spink5	serine peptidase inhibitor, Kazal type 5	3342	0.25
chr19_53781327_53781513	0.26	Rbm20	RNA binding motif protein 20	11888	0.17
chr2_31519719_31520357	0.24	Ass1	argininosuccinate synthetase 1	1548	0.36
chr16_24831205_24831356	0.24	Mir28a	microRNA 28a	3425	0.28
chr12_16577490_16577750	0.22	Lpin1	lipin 1	12100	0.23
chr3_116510337_116510525	0.22	Rtca	RNA 3'-terminal phosphate cyclase	2223	0.16
chr2_59979696_59979870	0.22	Gm13574	predicted gene 13574	12561	0.19
chr11_16913067_16913239	0.22	Egfr	epidermal growth factor receptor	7968	0.19
chr8_40906070_40906221	0.21	Slc7a2	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	7707	0.17
chr1_184748659_184749028	0.21	Gm34342	predicted gene, 34342	11866	0.14
chr7_44298836_44299206	0.20	Gm7238	predicted gene 7238	1866	0.11
chr16_49770118_49770298	0.20	Gm15518	predicted gene 15518	28662	0.19
chr19_10094218_10094369	0.20	Fads2	fatty acid desaturase 2	5577	0.16
chr4_95640632_95640805	0.20	Fggy	FGGY carbohydrate kinase domain containing	3831	0.31
chr11_99056309_99056460	0.20	Igfbp4	insulin-like growth factor binding protein 4	9073	0.12
chr10_20504473_20504624	0.20	Gm17229	predicted gene 17229	13616	0.21
chr11_16845424_16845700	0.19	Egfros	epidermal growth factor receptor, opposite strand	14860	0.2
chr12_8498096_8498247	0.19	Rhob	ras homolog family member B	1838	0.28
chr4_129063899_129064050	0.19	Rnf19b	ring finger protein 19B	5160	0.15
chr2_35174669_35174820	0.19	Cntrl	centriolin	504	0.76
chr12_24463865_24464016	0.19	Gm16372	predicted pseudogene 16372	29716	0.14
chr6_149359539_149359690	0.19	Gm15784	predicted gene 15784	2072	0.23
chr14_114864274_114864425	0.19	Gm49010	predicted gene, 49010	12161	0.18
chr2_58737784_58737935	0.19	Gm13559	predicted gene 13559	2780	0.27
chr7_93588215_93588366	0.19	Gm45039	predicted gene 45039	20026	0.19
chr13_24359125_24359350	0.19	Gm11342	predicted gene 11342	16713	0.12
chr19_12460408_12460573	0.18	Mpeg1	macrophage expressed gene 1	289	0.84
chr3_97620995_97621148	0.18	Fmo5	flavin containing monooxygenase 5	7733	0.14
chr14_88428338_88428489	0.18	Gm48930	predicted gene, 48930	12388	0.18
chr19_44399803_44399962	0.18	Scd1	stearoyl-Coenzyme A desaturase 1	6808	0.15
chrX_108663772_108663923	0.18	Gm379	predicted gene 379	608	0.84
chr8_109996628_109997116	0.17	Tat	tyrosine aminotransferase	6366	0.13
chr2_32415334_32415774	0.17	Slc25a25	solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 25	1017	0.34
chr17_50814204_50814359	0.17	Gm25177	predicted gene, 25177	102760	0.07
chr4_53222171_53222454	0.17	4930412L05Rik	RIKEN cDNA 4930412L05 gene	4455	0.21
chr5_102010547_102010959	0.17	Wdfy3	WD repeat and FYVE domain containing 3	29195	0.16
chr9_100488481_100488638	0.17	Il20rb	interleukin 20 receptor beta	1771	0.29
chr3_51238020_51238171	0.16	Noct	nocturnin	2111	0.23
chr11_51598115_51598266	0.16	Phykpl	5-phosphohydroxy-L-lysine phospholyase	1077	0.39
chr3_122130884_122131070	0.16	Abca4	ATP-binding cassette, sub-family A (ABC1), member 4	1025	0.49
chr7_72295313_72295464	0.16	Mctp2	multiple C2 domains, transmembrane 2	11220	0.29
chr9_85369091_85369242	0.16	Gm48832	predicted gene, 48832	21101	0.14
chr11_90269750_90269901	0.16	Mmd	monocyte to macrophage differentiation-associated	20349	0.21
chr4_83243559_83243710	0.16	Ttc39b	tetratricopeptide repeat domain 39B	10464	0.2
chr2_58784544_58784695	0.16	Upp2	uridine phosphorylase 2	19294	0.19
chr13_52186671_52186858	0.16	Gm48199	predicted gene, 48199	6353	0.28
chr4_6270082_6270233	0.16	Cyp7a1	cytochrome P450, family 7, subfamily a, polypeptide 1	5474	0.21
chr2_43522117_43522300	0.16	Gm13464	predicted gene 13464	2810	0.36
chr16_85566937_85567088	0.16	Gm2541	predicted pseudogene 2541	13069	0.22
chr3_158062237_158062399	0.16	Lrrc40	leucine rich repeat containing 40	40	0.97
chr12_69941545_69941731	0.16	Atl1	atlastin GTPase 1	4539	0.13
chr14_120368762_120368913	0.16	Mbnl2	muscleblind like splicing factor 2	10404	0.23
chr18_9782900_9783271	0.16	Gm23350	predicted gene, 23350	19823	0.12
chr1_67138759_67139000	0.16	Cps1	carbamoyl-phosphate synthetase 1	15853	0.23
chr18_16665331_16665535	0.16	Cdh2	cadherin 2	4636	0.31
chr3_81573214_81573380	0.16	Gm4857	predicted gene 4857	16472	0.28
chr8_36265509_36265688	0.15	Lonrf1	LON peptidase N-terminal domain and ring finger 1	16082	0.2
chr18_38888781_38888957	0.15	Gm5820	predicted gene 5820	3589	0.26
chr19_33489637_33489788	0.15	Lipo5	lipase, member O5	16521	0.14
chr16_45995065_45995216	0.15	Plcxd2	phosphatidylinositol-specific phospholipase C, X domain containing 2	15078	0.15
chr2_58771100_58771251	0.15	Upp2	uridine phosphorylase 2	5850	0.22
chr3_5396484_5396672	0.15	4930555M17Rik	RIKEN cDNA 4930555M17 gene	118755	0.06
chr2_31514522_31514710	0.15	Ass1	argininosuccinate synthetase 1	3874	0.21
chr11_43688020_43688171	0.15	Pwwp2a	PWWP domain containing 2A	3950	0.21
chr14_116316024_116316184	0.15	Gm38045	predicted gene, 38045	434111	0.01
chr10_21665548_21665708	0.15	Gm5420	predicted gene 5420	20783	0.2
chrY_90734416_90734573	0.15	Mid1-ps1	midline 1, pseudogene 1	18563	0.17
chr3_18152374_18152525	0.15	Gm23686	predicted gene, 23686	25176	0.2
chr16_87670516_87670809	0.14	Bach1	BTB and CNC homology 1, basic leucine zipper transcription factor 1	28283	0.17
chr4_150868400_150868675	0.14	Errfi1	ERBB receptor feedback inhibitor 1	13464	0.13
chr1_67210897_67211317	0.14	Gm15668	predicted gene 15668	38093	0.16
chr2_58779426_58779577	0.14	Upp2	uridine phosphorylase 2	14176	0.2
chr5_33024447_33024632	0.14	Ywhah	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide	2748	0.21
chr3_104218648_104218830	0.14	Magi3	membrane associated guanylate kinase, WW and PDZ domain containing 3	1364	0.29
chr2_134853818_134853969	0.14	Gm14036	predicted gene 14036	49944	0.15
chr4_62100969_62101120	0.14	Gm12910	predicted gene 12910	11887	0.13
chr8_93186224_93186375	0.14	Gm45909	predicted gene 45909	5059	0.15
chr2_147998244_147998434	0.14	9030622O22Rik	RIKEN cDNA 9030622O22 gene	22154	0.18
chrX_169972936_169973308	0.14	Mid1	midline 1	237	0.91
chr17_28420256_28420436	0.14	Fkbp5	FK506 binding protein 5	1819	0.21
chr8_67497857_67498024	0.14	Nat2	N-acetyltransferase 2 (arylamine N-acetyltransferase)	2992	0.21
chr7_119850861_119851025	0.14	Rexo5	RNA exonuclease 5	6737	0.15
chr5_130017444_130017684	0.14	Asl	argininosuccinate lyase	2842	0.16
chr11_61612422_61612587	0.14	Epn2	epsin 2	32817	0.12
chr6_23115074_23115260	0.14	Aass	aminoadipate-semialdehyde synthase	12413	0.16
chr7_136493976_136494136	0.14	Gm36849	predicted gene, 36849	140692	0.04
chr1_67156793_67157207	0.14	Cps1	carbamoyl-phosphate synthetase 1	33974	0.18
chr7_125056317_125056468	0.14	Gm45093	predicted gene 45093	13099	0.23
chr12_20815638_20815951	0.14	1700030C10Rik	RIKEN cDNA 1700030C10 gene	15	0.98
chr1_52465382_52465533	0.14	Nab1	Ngfi-A binding protein 1	1600	0.34
chr1_186581211_186581378	0.14	A730004F24Rik	RIKEN cDNA A730004F24 gene	22613	0.2
chr10_87565564_87566020	0.14	Pah	phenylalanine hydroxylase	19119	0.21
chr1_24116155_24116306	0.14	Gm26607	predicted gene, 26607	9045	0.17
chr11_16869435_16869808	0.14	Egfr	epidermal growth factor receptor	8529	0.21
chr19_40141969_40142120	0.14	Cyp2c70	cytochrome P450, family 2, subfamily c, polypeptide 70	45242	0.11
chr19_47578801_47579105	0.14	Slk	STE20-like kinase	725	0.6
chr7_101084310_101084461	0.14	Fchsd2	FCH and double SH3 domains 2	8478	0.17
chr13_4234942_4235096	0.14	Akr1c19	aldo-keto reductase family 1, member C19	1279	0.37
chr17_55903580_55903737	0.14	Zfp959	zinc finger protein 959	11190	0.1
chr11_98192679_98192909	0.13	Med1	mediator complex subunit 1	161	0.92
chr2_31499430_31499808	0.13	Ass1	argininosuccinate synthetase 1	1107	0.5
chr6_95118485_95118647	0.13	Kbtbd8	kelch repeat and BTB (POZ) domain containing 8	582	0.58
chr6_66996154_66996403	0.13	Gm36816	predicted gene, 36816	12135	0.12
chr5_38117047_38117323	0.13	Stx18	syntaxin 18	3724	0.2
chr7_118572136_118572408	0.13	Tmc7	transmembrane channel-like gene family 7	5645	0.16
chr10_24258031_24258221	0.13	Moxd1	monooxygenase, DBH-like 1	34581	0.16
chr7_49734781_49734959	0.13	Htatip2	HIV-1 Tat interactive protein 2	24245	0.19
chr19_33480626_33480777	0.13	Lipo5	lipase, member O5	7510	0.16
chr18_38856050_38856246	0.13	Fgf1	fibroblast growth factor 1	2600	0.31
chr5_148633016_148633167	0.13	Gm29815	predicted gene, 29815	19447	0.18
chr10_55194027_55194219	0.13	Gm46190	predicted gene, 46190	69761	0.14
chr5_137975596_137975772	0.13	Azgp1	alpha-2-glycoprotein 1, zinc	5836	0.09
chr8_56345237_56345388	0.13	Gm45540	predicted gene 45540	34008	0.18
chr13_114485155_114485339	0.13	Fst	follistatin	26296	0.14
chr6_42251414_42251583	0.13	Gstk1	glutathione S-transferase kappa 1	5475	0.12
chr3_51233010_51233232	0.13	Gm38357	predicted gene, 38357	1204	0.38
chr3_109307549_109307748	0.13	Vav3	vav 3 oncogene	33005	0.21
chr1_121297700_121297851	0.13	Gm38283	predicted gene, 38283	3056	0.23
chr10_69208679_69208830	0.13	Rhobtb1	Rho-related BTB domain containing 1	202	0.94
chr11_16855071_16855379	0.13	Egfr	epidermal growth factor receptor	22925	0.17
chr1_73966648_73966904	0.13	Tns1	tensin 1	3733	0.28
chr9_53288790_53288968	0.13	Exph5	exophilin 5	12791	0.18
chr7_116331137_116331288	0.13	Rps13	ribosomal protein S13	1970	0.19
chr19_6053827_6053978	0.13	AC131692.1	mitochondrial ribosomal protein L49 (Mrpl49) pseudogene	1764	0.1
chr16_46841628_46841787	0.13	Gm6912	predicted gene 6912	232491	0.02
chr16_24201028_24201179	0.13	Gm31814	predicted gene, 31814	15143	0.2
chr3_9751433_9751584	0.13	Gm16337	predicted gene 16337	6099	0.23
chr9_14045065_14045224	0.13	1700019J19Rik	RIKEN cDNA 1700019J19 gene	44476	0.14
chr14_62001768_62001919	0.13	Gm47953	predicted gene, 47953	10476	0.25
chr8_10899350_10899661	0.13	4833411C07Rik	RIKEN cDNA 4833411C07 gene	417	0.64
chr19_10062797_10062948	0.12	Fads3	fatty acid desaturase 3	6620	0.14
chr10_40511211_40511581	0.12	Gm18671	predicted gene, 18671	37496	0.14
chr11_63884359_63884556	0.12	Hmgb1-ps3	high mobility group box 1, pseudogene 3	37639	0.15
chr2_45463913_45464105	0.12	Gm13479	predicted gene 13479	106744	0.07
chr2_58783629_58783834	0.12	Upp2	uridine phosphorylase 2	18406	0.19
chrY_90810953_90811113	0.12	Gm47283	predicted gene, 47283	20582	0.16
chr11_7815566_7815774	0.12	Gm27393	predicted gene, 27393	70835	0.13
chr14_86309035_86309286	0.12	Gm23926	predicted gene, 23926	2218	0.22
chr10_10818225_10818395	0.12	4930567K20Rik	RIKEN cDNA 4930567K20 gene	67230	0.1
chr11_16889902_16890060	0.12	Egfr	epidermal growth factor receptor	11831	0.19
chr17_64609780_64609995	0.12	Man2a1	mannosidase 2, alpha 1	9151	0.26
chr16_25011043_25011318	0.12	A230028O05Rik	RIKEN cDNA A230028O05 gene	48459	0.18
chr3_141502934_141503090	0.12	Unc5c	unc-5 netrin receptor C	37341	0.18
chr14_11801019_11801346	0.12	Gm48602	predicted gene, 48602	33239	0.19
chr5_125325436_125325605	0.12	Scarb1	scavenger receptor class B, member 1	747	0.57
chrY_90794490_90794856	0.12	Gm47283	predicted gene, 47283	4222	0.21
chr13_101895557_101895722	0.12	Gm17832	predicted gene, 17832	24781	0.19
chr1_193926856_193927030	0.12	Gm21362	predicted gene, 21362	59934	0.16
chr10_4599676_4599928	0.12	Esr1	estrogen receptor 1 (alpha)	11791	0.21
chr3_52618299_52618553	0.12	Gm10293	predicted pseudogene 10293	5591	0.27
chr6_43851681_43851832	0.12	Gm7783	predicted gene 7783	5148	0.27
chr19_44398583_44398737	0.12	Scd1	stearoyl-Coenzyme A desaturase 1	8030	0.15
chr5_100371529_100371680	0.12	Sec31a	Sec31 homolog A (S. cerevisiae)	1880	0.3
chr5_135713964_135714115	0.12	Por	P450 (cytochrome) oxidoreductase	1966	0.2
chr18_43980831_43980982	0.12	Spink5	serine peptidase inhibitor, Kazal type 5	17671	0.17
chr13_46023839_46023999	0.12	Gm45949	predicted gene, 45949	36678	0.16
chr8_3493535_3493936	0.12	Zfp358	zinc finger protein 358	565	0.6
chr8_23189899_23190050	0.12	Gpat4	glycerol-3-phosphate acyltransferase 4	964	0.41
chr11_29526849_29527005	0.12	Mtif2	mitochondrial translational initiation factor 2	470	0.69
chr10_68093593_68093917	0.12	Arid5b	AT rich interactive domain 5B (MRF1-like)	42871	0.14
chr4_99028977_99029128	0.12	Angptl3	angiopoietin-like 3	1902	0.32
chr16_22511358_22511522	0.12	9230117E06Rik	RIKEN cDNA 9230117E06 gene	40	0.96
chr2_38585174_38585360	0.12	Gm44183	predicted gene, 44183	18913	0.12
chr19_46603380_46603531	0.12	Wbp1l	WW domain binding protein 1 like	4331	0.16
chr5_87499011_87499178	0.12	Ugt2a1	UDP glucuronosyltransferase 2 family, polypeptide A1	8223	0.12
chr6_31110022_31110173	0.12	5330406M23Rik	RIKEN cDNA 5330406M23 gene	823	0.49
chr11_16883025_16883203	0.12	Egfr	epidermal growth factor receptor	4964	0.23
chr3_107315148_107315299	0.12	Rbm15	RNA binding motif protein 15	17878	0.13
chr13_63231532_63231825	0.12	Aopep	aminopeptidase O	8351	0.11
chr4_45514779_45514987	0.12	Gm22518	predicted gene, 22518	14331	0.14
chr15_97047820_97047997	0.12	Slc38a4	solute carrier family 38, member 4	2179	0.42
chr10_10925217_10925440	0.12	Gm48406	predicted gene, 48406	110588	0.06
chr2_59979903_59980091	0.12	Gm13574	predicted gene 13574	12347	0.19
chr8_40875940_40876218	0.12	Slc7a2	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	1131	0.44
chr17_27621069_27621255	0.12	Nudt3	nudix (nucleotide diphosphate linked moiety X)-type motif 3	1231	0.25
chr2_32680438_32680786	0.11	Fpgs	folylpolyglutamyl synthetase	4392	0.08
chr5_20881136_20881540	0.11	Phtf2	putative homeodomain transcription factor 2	707	0.46
chr8_40882534_40882732	0.11	Slc7a2	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	7685	0.16
chr19_10052563_10053085	0.11	Fads3	fatty acid desaturase 3	127	0.94
chr10_52234541_52234692	0.11	Dcbld1	discoidin, CUB and LCCL domain containing 1	979	0.54
chr2_115537784_115537935	0.11	3110099E03Rik	RIKEN cDNA 3110099E03 gene	10115	0.22
chr19_58370035_58370186	0.11	Gfra1	glial cell line derived neurotrophic factor family receptor alpha 1	84356	0.09
chr1_184276149_184276321	0.11	Gm37223	predicted gene, 37223	82094	0.09
chr1_89710237_89710633	0.11	4933400F21Rik	RIKEN cDNA 4933400F21 gene	26527	0.21
chr3_116302483_116302634	0.11	Gm29151	predicted gene 29151	47545	0.11
chr13_114469994_114470145	0.11	Fst	follistatin	11118	0.15
chr12_103768009_103768212	0.11	Serpina1d	serine (or cysteine) peptidase inhibitor, clade A, member 1D	5482	0.12
chr10_19457260_19457442	0.11	Gm33104	predicted gene, 33104	29364	0.18
chr10_4531024_4531190	0.11	Ccdc170	coiled-coil domain containing 170	1888	0.34
chr11_99081665_99081816	0.11	Tns4	tensin 4	6399	0.15
chr1_58190709_58190860	0.11	Aox4	aldehyde oxidase 4	19613	0.16
chr8_54468376_54468527	0.11	Gm45553	predicted gene 45553	45699	0.14
chr18_75499322_75499625	0.11	Gm10532	predicted gene 10532	15172	0.25
chr13_51089168_51089510	0.11	Spin1	spindlin 1	11541	0.24
chr1_136893539_136893740	0.11	Nr5a2	nuclear receptor subfamily 5, group A, member 2	46944	0.13
chr17_80090476_80090673	0.11	Gm23125	predicted gene, 23125	14363	0.14
chr16_36770901_36771058	0.11	Slc15a2	solute carrier family 15 (H+/peptide transporter), member 2	2299	0.18
chr5_20858729_20858886	0.11	Phtf2	putative homeodomain transcription factor 2	3616	0.22

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of Sox13

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.4	GO:1903800	positive regulation of production of miRNAs involved in gene silencing by miRNA(GO:1903800)
0.1	0.6	GO:0006526	arginine biosynthetic process(GO:0006526)
0.0	0.2	GO:1903352	ornithine transport(GO:0015822) L-ornithine transmembrane transport(GO:1903352)
0.0	0.0	GO:0006106	fumarate metabolic process(GO:0006106)
0.0	0.1	GO:0070318	positive regulation of G0 to G1 transition(GO:0070318)
0.0	0.1	GO:0097167	circadian regulation of translation(GO:0097167)
0.0	0.1	GO:0006538	glutamate catabolic process(GO:0006538)
0.0	0.1	GO:0097460	ferrous iron import into cell(GO:0097460)
0.0	0.1	GO:0042851	L-alanine metabolic process(GO:0042851)
0.0	0.1	GO:2001013	epithelial cell proliferation involved in renal tubule morphogenesis(GO:2001013)
0.0	0.1	GO:0006166	purine ribonucleoside salvage(GO:0006166)
0.0	0.1	GO:0071895	odontoblast differentiation(GO:0071895)
0.0	0.1	GO:0006556	S-adenosylmethionine biosynthetic process(GO:0006556)
0.0	0.1	GO:1900425	negative regulation of defense response to bacterium(GO:1900425)
0.0	0.2	GO:0006559	L-phenylalanine catabolic process(GO:0006559) erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process(GO:1902222)
0.0	0.1	GO:0015959	diadenosine polyphosphate metabolic process(GO:0015959)
0.0	0.1	GO:0007571	age-dependent response to oxidative stress(GO:0001306) age-dependent general metabolic decline(GO:0007571)
0.0	0.1	GO:0003062	regulation of heart rate by chemical signal(GO:0003062)
0.0	0.1	GO:0019627	urea cycle(GO:0000050) urea metabolic process(GO:0019627)
0.0	0.1	GO:1901078	negative regulation of relaxation of muscle(GO:1901078)
0.0	0.1	GO:2000729	positive regulation of mesenchymal cell proliferation involved in ureter development(GO:2000729)
0.0	0.1	GO:0070858	negative regulation of bile acid biosynthetic process(GO:0070858) negative regulation of bile acid metabolic process(GO:1904252)
0.0	0.1	GO:0019805	quinolinate biosynthetic process(GO:0019805)
0.0	0.1	GO:0006553	lysine metabolic process(GO:0006553)
0.0	0.1	GO:2000437	monocyte extravasation(GO:0035696) regulation of monocyte extravasation(GO:2000437)
0.0	0.1	GO:0010571	positive regulation of nuclear cell cycle DNA replication(GO:0010571)
0.0	0.1	GO:1901509	regulation of endothelial tube morphogenesis(GO:1901509)
0.0	0.1	GO:2000359	regulation of binding of sperm to zona pellucida(GO:2000359)
0.0	0.1	GO:0003383	apical constriction(GO:0003383)
0.0	0.0	GO:0001807	regulation of type IV hypersensitivity(GO:0001807)
0.0	0.1	GO:0034638	phosphatidylcholine catabolic process(GO:0034638)
0.0	0.2	GO:0044539	long-chain fatty acid import(GO:0044539)
0.0	0.1	GO:0060633	negative regulation of transcription initiation from RNA polymerase II promoter(GO:0060633) negative regulation of DNA-templated transcription, initiation(GO:2000143)
0.0	0.1	GO:0071492	cellular response to UV-A(GO:0071492)
0.0	0.1	GO:0065001	specification of axis polarity(GO:0065001)
0.0	0.1	GO:0097118	neuroligin clustering involved in postsynaptic membrane assembly(GO:0097118)
0.0	0.1	GO:0010835	regulation of protein ADP-ribosylation(GO:0010835)
0.0	0.1	GO:0009597	detection of virus(GO:0009597)
0.0	0.2	GO:0032754	positive regulation of interleukin-5 production(GO:0032754)
0.0	0.1	GO:0035973	aggrephagy(GO:0035973)
0.0	0.1	GO:0010986	positive regulation of lipoprotein particle clearance(GO:0010986)
0.0	0.1	GO:2000017	positive regulation of determination of dorsal identity(GO:2000017)
0.0	0.1	GO:0006477	protein sulfation(GO:0006477)
0.0	0.1	GO:0014016	neuroblast differentiation(GO:0014016)
0.0	0.2	GO:0061469	regulation of type B pancreatic cell proliferation(GO:0061469)
0.0	0.1	GO:0001692	histamine metabolic process(GO:0001692)
0.0	0.1	GO:0060523	prostate epithelial cord elongation(GO:0060523)
0.0	0.0	GO:0000720	pyrimidine dimer repair by nucleotide-excision repair(GO:0000720)
0.0	0.0	GO:0034635	glutathione transport(GO:0034635) tripeptide transport(GO:0042939)
0.0	0.1	GO:0070857	regulation of bile acid biosynthetic process(GO:0070857)
0.0	0.1	GO:1905065	positive regulation of vascular smooth muscle cell differentiation(GO:1905065)
0.0	0.1	GO:1903966	monounsaturated fatty acid metabolic process(GO:1903964) monounsaturated fatty acid biosynthetic process(GO:1903966)
0.0	0.1	GO:0018894	dibenzo-p-dioxin metabolic process(GO:0018894)
0.0	0.1	GO:1904479	negative regulation of intestinal absorption(GO:1904479)
0.0	0.1	GO:0038161	prolactin signaling pathway(GO:0038161)
0.0	0.1	GO:0002071	glandular epithelial cell maturation(GO:0002071)
0.0	0.1	GO:1903336	negative regulation of vacuolar transport(GO:1903336)
0.0	0.1	GO:0060687	regulation of branching involved in prostate gland morphogenesis(GO:0060687)
0.0	0.1	GO:0015817	histidine transport(GO:0015817)
0.0	0.1	GO:0055091	phospholipid homeostasis(GO:0055091)
0.0	0.1	GO:0018094	protein polyglycylation(GO:0018094)
0.0	0.1	GO:0036112	medium-chain fatty-acyl-CoA metabolic process(GO:0036112)
0.0	0.1	GO:0060398	regulation of growth hormone receptor signaling pathway(GO:0060398)
0.0	0.1	GO:0006013	mannose metabolic process(GO:0006013)
0.0	0.1	GO:0033129	positive regulation of histone phosphorylation(GO:0033129)
0.0	0.1	GO:0090074	negative regulation of protein homodimerization activity(GO:0090074)
0.0	0.0	GO:0045658	regulation of neutrophil differentiation(GO:0045658)
0.0	0.1	GO:0006642	triglyceride mobilization(GO:0006642)
0.0	0.0	GO:0045917	positive regulation of complement activation(GO:0045917) positive regulation of protein activation cascade(GO:2000259)
0.0	0.1	GO:0071763	nuclear membrane organization(GO:0071763)
0.0	0.0	GO:0046104	thymidine metabolic process(GO:0046104)
0.0	0.0	GO:0034287	detection of carbohydrate stimulus(GO:0009730) detection of hexose stimulus(GO:0009732) detection of monosaccharide stimulus(GO:0034287) detection of glucose(GO:0051594)
0.0	0.0	GO:0046684	response to pyrethroid(GO:0046684)
0.0	0.0	GO:0001732	formation of cytoplasmic translation initiation complex(GO:0001732)
0.0	0.0	GO:0000430	regulation of transcription from RNA polymerase II promoter by glucose(GO:0000430) positive regulation of transcription from RNA polymerase II promoter by glucose(GO:0000432)
0.0	0.1	GO:0034755	iron ion transmembrane transport(GO:0034755)
0.0	0.0	GO:2000152	regulation of ubiquitin-specific protease activity(GO:2000152)
0.0	0.0	GO:0042126	nitrate metabolic process(GO:0042126)
0.0	0.1	GO:0046909	intermembrane transport(GO:0046909)
0.0	0.1	GO:1903818	positive regulation of delayed rectifier potassium channel activity(GO:1902261) positive regulation of voltage-gated potassium channel activity(GO:1903818)
0.0	0.0	GO:0042908	xenobiotic transport(GO:0042908)
0.0	0.0	GO:0030327	prenylated protein catabolic process(GO:0030327)
0.0	0.0	GO:0048769	sarcomerogenesis(GO:0048769)
0.0	0.1	GO:0075522	IRES-dependent viral translational initiation(GO:0075522)
0.0	0.1	GO:0015074	DNA integration(GO:0015074)
0.0	0.0	GO:1990086	lens fiber cell apoptotic process(GO:1990086)
0.0	0.1	GO:0033262	regulation of nuclear cell cycle DNA replication(GO:0033262)
0.0	0.0	GO:0050427	3'-phosphoadenosine 5'-phosphosulfate metabolic process(GO:0050427)
0.0	0.0	GO:0010760	negative regulation of macrophage chemotaxis(GO:0010760)
0.0	0.0	GO:0021823	cerebral cortex tangential migration using cell-cell interactions(GO:0021823) postnatal olfactory bulb interneuron migration(GO:0021827)
0.0	0.1	GO:0006265	DNA topological change(GO:0006265)
0.0	0.1	GO:1901409	regulation of phosphorylation of RNA polymerase II C-terminal domain(GO:1901407) positive regulation of phosphorylation of RNA polymerase II C-terminal domain(GO:1901409)
0.0	0.0	GO:0097475	motor neuron migration(GO:0097475) spinal cord motor neuron migration(GO:0097476)
0.0	0.1	GO:0043102	amino acid salvage(GO:0043102) L-methionine biosynthetic process(GO:0071265) L-methionine salvage(GO:0071267)
0.0	0.0	GO:1902683	regulation of receptor localization to synapse(GO:1902683)
0.0	0.0	GO:0071503	response to heparin(GO:0071503) cellular response to heparin(GO:0071504)
0.0	0.0	GO:0019042	viral latency(GO:0019042)
0.0	0.0	GO:0009826	unidimensional cell growth(GO:0009826)
0.0	0.0	GO:0008228	opsonization(GO:0008228)
0.0	0.0	GO:0070295	renal water absorption(GO:0070295)
0.0	0.0	GO:0006285	base-excision repair, AP site formation(GO:0006285)
0.0	0.1	GO:0043569	negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569)
0.0	0.1	GO:0010944	negative regulation of transcription by competitive promoter binding(GO:0010944)
0.0	0.0	GO:0007412	axon target recognition(GO:0007412)
0.0	0.1	GO:0045647	negative regulation of erythrocyte differentiation(GO:0045647)
0.0	0.1	GO:0060926	cardiac pacemaker cell development(GO:0060926)
0.0	0.0	GO:0018243	protein O-linked glycosylation via threonine(GO:0018243)
0.0	0.1	GO:0042436	tryptophan catabolic process(GO:0006569) tryptophan catabolic process to kynurenine(GO:0019441) indole-containing compound catabolic process(GO:0042436) indolalkylamine catabolic process(GO:0046218)
0.0	0.0	GO:0032349	positive regulation of aldosterone metabolic process(GO:0032346) positive regulation of aldosterone biosynthetic process(GO:0032349)
0.0	0.0	GO:0048807	female genitalia morphogenesis(GO:0048807)
0.0	0.0	GO:0035262	gonad morphogenesis(GO:0035262)
0.0	0.1	GO:0009256	10-formyltetrahydrofolate metabolic process(GO:0009256)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.4	GO:0097487	multivesicular body, internal vesicle(GO:0097487)
0.1	0.3	GO:0045098	type III intermediate filament(GO:0045098)
0.0	0.2	GO:0097433	dense body(GO:0097433)
0.0	0.1	GO:0031933	telomeric heterochromatin(GO:0031933)
0.0	0.2	GO:0070852	cell body fiber(GO:0070852)
0.0	0.1	GO:0097209	epidermal lamellar body(GO:0097209)
0.0	0.1	GO:0033269	internode region of axon(GO:0033269)
0.0	0.1	GO:0043625	delta DNA polymerase complex(GO:0043625)
0.0	0.1	GO:0005579	membrane attack complex(GO:0005579)
0.0	0.1	GO:0097413	Lewy body(GO:0097413)
0.0	0.1	GO:0031313	extrinsic component of endosome membrane(GO:0031313)
0.0	0.1	GO:0033553	rDNA heterochromatin(GO:0033553)
0.0	0.0	GO:1990635	proximal dendrite(GO:1990635)
0.0	0.0	GO:0097648	G-protein coupled receptor dimeric complex(GO:0038037) G-protein coupled receptor complex(GO:0097648)
0.0	0.0	GO:0070552	BRISC complex(GO:0070552)
0.0	0.0	GO:0048179	activin receptor complex(GO:0048179)
0.0	0.1	GO:0032045	guanyl-nucleotide exchange factor complex(GO:0032045)
0.0	0.1	GO:0036056	filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.0	0.5	GO:0009295	nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.0	0.0	GO:0032541	cortical endoplasmic reticulum(GO:0032541)
0.0	0.1	GO:0005847	mRNA cleavage and polyadenylation specificity factor complex(GO:0005847)
0.0	0.1	GO:0031838	haptoglobin-hemoglobin complex(GO:0031838)
0.0	0.1	GO:0097431	mitotic spindle pole(GO:0097431)
0.0	0.1	GO:0008250	oligosaccharyltransferase complex(GO:0008250)
0.0	0.1	GO:0005671	Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)
0.0	0.0	GO:0000306	extrinsic component of vacuolar membrane(GO:0000306)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.4	GO:0005006	epidermal growth factor-activated receptor activity(GO:0005006)
0.1	0.4	GO:0016743	carboxyl- or carbamoyltransferase activity(GO:0016743)
0.0	0.2	GO:0061665	SUMO ligase activity(GO:0061665)
0.0	0.4	GO:0016215	acyl-CoA desaturase activity(GO:0016215)
0.0	0.2	GO:0050693	LBD domain binding(GO:0050693)
0.0	0.2	GO:0000064	L-ornithine transmembrane transporter activity(GO:0000064)
0.0	0.1	GO:1990829	C-rich single-stranded DNA binding(GO:1990829)
0.0	0.1	GO:0034186	apolipoprotein A-I binding(GO:0034186)
0.0	0.1	GO:0004505	phenylalanine 4-monooxygenase activity(GO:0004505)
0.0	0.1	GO:0004366	glycerol-3-phosphate O-acyltransferase activity(GO:0004366)
0.0	0.1	GO:0070053	thrombospondin receptor activity(GO:0070053)
0.0	0.1	GO:0070728	leucine binding(GO:0070728)
0.0	0.1	GO:0004427	inorganic diphosphatase activity(GO:0004427)
0.0	0.1	GO:0004095	carnitine O-palmitoyltransferase activity(GO:0004095)
0.0	0.1	GO:0070644	vitamin D response element binding(GO:0070644)
0.0	0.1	GO:0080130	L-phenylalanine:2-oxoglutarate aminotransferase activity(GO:0080130)
0.0	0.1	GO:0008199	ferric iron binding(GO:0008199)
0.0	0.1	GO:0004528	phosphodiesterase I activity(GO:0004528)
0.0	0.1	GO:0008898	S-adenosylmethionine-homocysteine S-methyltransferase activity(GO:0008898)
0.0	0.1	GO:0070087	chromo shadow domain binding(GO:0070087)
0.0	0.0	GO:0016842	amidine-lyase activity(GO:0016842)
0.0	0.1	GO:0004468	lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468)
0.0	0.1	GO:0016151	nickel cation binding(GO:0016151)
0.0	0.1	GO:0003941	L-serine ammonia-lyase activity(GO:0003941)
0.0	0.1	GO:0015174	basic amino acid transmembrane transporter activity(GO:0015174)
0.0	0.1	GO:0004908	interleukin-1 receptor activity(GO:0004908)
0.0	0.1	GO:0019784	NEDD8-specific protease activity(GO:0019784)
0.0	0.1	GO:0004833	tryptophan 2,3-dioxygenase activity(GO:0004833)
0.0	0.1	GO:0003976	UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity(GO:0003976)
0.0	0.1	GO:0004556	alpha-amylase activity(GO:0004556)
0.0	0.1	GO:0016715	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen(GO:0016715)
0.0	0.1	GO:0008467	[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity(GO:0008467)
0.0	0.0	GO:0016822	hydrolase activity, acting on acid carbon-carbon bonds(GO:0016822) hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances(GO:0016823)
0.0	0.1	GO:0004060	arylamine N-acetyltransferase activity(GO:0004060)
0.0	0.1	GO:0003997	acyl-CoA oxidase activity(GO:0003997)
0.0	0.1	GO:0004566	beta-glucuronidase activity(GO:0004566)
0.0	0.0	GO:0015315	hexose phosphate transmembrane transporter activity(GO:0015119) organophosphate:inorganic phosphate antiporter activity(GO:0015315) hexose-phosphate:inorganic phosphate antiporter activity(GO:0015526) glucose 6-phosphate:inorganic phosphate antiporter activity(GO:0061513)
0.0	0.1	GO:0003831	beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity(GO:0003831)
0.0	0.0	GO:0035651	AP-3 adaptor complex binding(GO:0035651)
0.0	0.1	GO:0030284	estrogen receptor activity(GO:0030284)
0.0	0.0	GO:0001069	regulatory region RNA binding(GO:0001069)
0.0	0.0	GO:0008384	IkappaB kinase activity(GO:0008384)
0.0	0.2	GO:0015643	toxic substance binding(GO:0015643)
0.0	0.1	GO:0102391	decanoate--CoA ligase activity(GO:0102391)
0.0	0.0	GO:0000403	Y-form DNA binding(GO:0000403)
0.0	0.0	GO:0047023	androsterone dehydrogenase activity(GO:0047023)
0.0	0.2	GO:0016646	oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor(GO:0016646)
0.0	0.0	GO:0035939	microsatellite binding(GO:0035939)
0.0	0.1	GO:0004726	non-membrane spanning protein tyrosine phosphatase activity(GO:0004726)
0.0	0.1	GO:0004499	N,N-dimethylaniline monooxygenase activity(GO:0004499)
0.0	0.1	GO:0003958	NADPH-hemoprotein reductase activity(GO:0003958)
0.0	0.1	GO:0035312	5'-3' exodeoxyribonuclease activity(GO:0035312)
0.0	0.1	GO:0002094	polyprenyltransferase activity(GO:0002094)
0.0	0.2	GO:0034237	protein kinase A regulatory subunit binding(GO:0034237)
0.0	0.1	GO:0016421	CoA carboxylase activity(GO:0016421)
0.0	0.1	GO:0031994	insulin-like growth factor I binding(GO:0031994)
0.0	0.0	GO:0030942	endoplasmic reticulum signal peptide binding(GO:0030942)
0.0	0.1	GO:0003680	AT DNA binding(GO:0003680)
0.0	0.2	GO:0004435	phosphatidylinositol phospholipase C activity(GO:0004435)
0.0	0.0	GO:0016532	superoxide dismutase copper chaperone activity(GO:0016532)
0.0	0.1	GO:0004652	polynucleotide adenylyltransferase activity(GO:0004652)
0.0	0.0	GO:0003846	2-acylglycerol O-acyltransferase activity(GO:0003846)
0.0	0.1	GO:0008430	selenium binding(GO:0008430)
0.0	0.0	GO:0004784	superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721)

Gene overrepresentation in curated gene sets: canonical pathways category:

Total log-likelihood	Term	Description
0.4	PID ERBB NETWORK PATHWAY	ErbB receptor signaling network
0.0	PID MAPK TRK PATHWAY	Trk receptor signaling mediated by the MAPK pathway
0.4	PID RXR VDR PATHWAY	RXR and RAR heterodimerization with other nuclear receptor
0.0	SA PTEN PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.1	SIG PIP3 SIGNALING IN CARDIAC MYOCTES	Genes related to PIP3 signaling in cardiac myocytes

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Total log-likelihood	Term	Description
0.4	REACTOME SHC1 EVENTS IN EGFR SIGNALING	Genes involved in SHC1 events in EGFR signaling
0.3	REACTOME PYRIMIDINE CATABOLISM	Genes involved in Pyrimidine catabolism
0.2	REACTOME ALPHA LINOLENIC ACID ALA METABOLISM	Genes involved in alpha-linolenic acid (ALA) metabolism
0.1	REACTOME TRYPTOPHAN CATABOLISM	Genes involved in Tryptophan catabolism
0.0	REACTOME ENDOSOMAL VACUOLAR PATHWAY	Genes involved in Endosomal/Vacuolar pathway
0.3	REACTOME RORA ACTIVATES CIRCADIAN EXPRESSION	Genes involved in RORA Activates Circadian Expression
0.0	REACTOME XENOBIOTICS	Genes involved in Xenobiotics
0.2	REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA HYDROXYCHOLESTEROL	Genes involved in Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
0.0	REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE	Genes involved in Synthesis of PIPs at the late endosome membrane
0.1	REACTOME RECYCLING OF BILE ACIDS AND SALTS	Genes involved in Recycling of bile acids and salts
0.3	REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE	Genes involved in Amino acid transport across the plasma membrane