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ENCSR904DTN: DNase-seq of mouse liver in constant darkness

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for Sox17

Z-value: 1.53

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Transcription factors associated with Sox17

Gene Symbol	Gene ID	Gene Info
Sox17 Ensembl NCBI MGI UniProt	ENSMUSG00000025902.7	Sox17

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

Gene	Promoter	Distance	Association probability	Pearson corr. coef.	P-value	Plot
Sox17	chr1_4479698_4479869	13821	0.141728	-0.71	1.1e-01	Click!

Activity of the Sox17 motif across conditions

Conditions sorted by the z-value of the Sox17 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr13_62909790_62909949	0.78	Fbp1	fructose bisphosphatase 1	21587	0.13
chr3_138289329_138289480	0.76	Adh1	alcohol dehydrogenase 1 (class I)	11753	0.11
chr12_69941545_69941731	0.73	Atl1	atlastin GTPase 1	4539	0.13
chr17_62789514_62789722	0.68	Efna5	ephrin A5	91526	0.1
chr1_87339717_87339868	0.66	Gm22549	predicted gene, 22549	1769	0.26
chr16_43168807_43168974	0.61	Gm15712	predicted gene 15712	15683	0.21
chr3_94339066_94339223	0.57	Them5	thioesterase superfamily member 5	2955	0.11
chr10_83310985_83311139	0.57	Slc41a2	solute carrier family 41, member 2	6687	0.19
chr16_43276603_43276913	0.56	Zbtb20	zinc finger and BTB domain containing 20	29474	0.15
chr19_26823384_26823535	0.55	4931403E22Rik	RIKEN cDNA 4931403E22 gene	448	0.84
chr5_67019971_67020122	0.55	Gm42713	predicted gene 42713	19330	0.12
chr12_57540843_57541103	0.54	Foxa1	forkhead box A1	5148	0.17
chr15_3506426_3506577	0.52	Ghr	growth hormone receptor	34857	0.21
chr7_80625574_80625744	0.52	Crtc3	CREB regulated transcription coactivator 3	3967	0.19
chr12_45065771_45065940	0.51	Stxbp6	syntaxin binding protein 6 (amisyn)	8257	0.21
chr1_21260733_21261242	0.51	Gsta3	glutathione S-transferase, alpha 3	7466	0.11
chr12_69941731_69941931	0.51	Atl1	atlastin GTPase 1	4346	0.13
chr4_53039519_53039670	0.48	Abca1	ATP-binding cassette, sub-family A (ABC1), member 1	1332	0.41
chr3_97649987_97650151	0.46	Prkab2	protein kinase, AMP-activated, beta 2 non-catalytic subunit	8124	0.13
chr9_9565147_9565311	0.45	Gm47334	predicted gene, 47334	1142	0.57
chr15_3458621_3458946	0.45	Ghr	growth hormone receptor	12861	0.28
chr11_68865350_68865528	0.44	Ndel1	nudE neurodevelopment protein 1 like 1	446	0.74
chr6_90469663_90469814	0.44	Klf15	Kruppel-like factor 15	2620	0.15
chr12_40230630_40230800	0.44	Gm47954	predicted gene, 47954	4933	0.12
chr8_127097367_127097518	0.43	Pard3	par-3 family cell polarity regulator	24202	0.18
chr1_60609032_60609279	0.43	Gm23762	predicted gene, 23762	4648	0.15
chr9_112027249_112027400	0.42	Mir128-2	microRNA 128-2	91387	0.08
chr14_10751127_10751283	0.42	Fhitos	fragile histidine triad gene, opposite strand	12652	0.25
chr1_67201803_67201976	0.42	Gm15668	predicted gene 15668	47311	0.14
chr13_75543303_75543454	0.42	Gm3926	predicted gene 3926	19030	0.15
chr1_39425203_39425354	0.42	Gm37265	predicted gene, 37265	5346	0.19
chr16_32896347_32896498	0.41	Fyttd1	forty-two-three domain containing 1	1331	0.34
chr7_125256750_125256907	0.41	Gm21957	predicted gene, 21957	36942	0.16
chr15_4836304_4836788	0.41	Gm49074	predicted gene, 49074	10841	0.18
chr4_148617242_148617393	0.41	Tardbp	TAR DNA binding protein	337	0.8
chr12_8796924_8797075	0.40	Sdc1	syndecan 1	25196	0.16
chr7_132924974_132925182	0.40	1500002F19Rik	RIKEN cDNA 1500002F19 gene	6025	0.15
chr5_90891820_90892079	0.39	Cxcl1	chemokine (C-X-C motif) ligand 1	706	0.49
chr10_20024835_20025010	0.39	Map3k5	mitogen-activated protein kinase kinase kinase 5	73867	0.09
chr13_46676987_46677175	0.39	Nup153	nucleoporin 153	4871	0.18
chr2_11712487_11713017	0.39	Il15ra	interleukin 15 receptor, alpha chain	5575	0.16
chr14_14789749_14789914	0.39	Slc4a7	solute carrier family 4, sodium bicarbonate cotransporter, member 7	3904	0.26
chr13_36533643_36534408	0.39	Fars2	phenylalanine-tRNA synthetase 2 (mitochondrial)	3072	0.22
chr17_64765537_64765696	0.38	Dreh	down-regulated in hepatocellular carcinoma	1495	0.41
chr19_29520625_29520778	0.38	A930007I19Rik	RIKEN cDNA A930007I19 gene	269	0.89
chr7_30943687_30943953	0.38	Hamp	hepcidin antimicrobial peptide	212	0.82
chr9_57255390_57255612	0.38	1700017B05Rik	RIKEN cDNA 1700017B05 gene	6008	0.17
chr13_112500358_112500528	0.38	Il6st	interleukin 6 signal transducer	25397	0.14
chr2_181461420_181461583	0.38	Zbtb46	zinc finger and BTB domain containing 46	2075	0.19
chr14_117447795_117448102	0.38	Mir6239	microRNA 6239	505899	0.0
chr4_150393280_150393601	0.38	Rere	arginine glutamic acid dipeptide (RE) repeats	12954	0.22
chr8_122985769_122985939	0.37	Gm24445	predicted gene, 24445	2911	0.19
chr9_55541381_55541949	0.37	Isl2	insulin related protein 2 (islet 2)	458	0.61
chr18_36656725_36657021	0.37	Ankhd1	ankyrin repeat and KH domain containing 1	1363	0.23
chr2_167727310_167727515	0.37	A530013C23Rik	RIKEN cDNA A530013C23 gene	36231	0.09
chr14_34675574_34675754	0.37	Wapl	WAPL cohesin release factor	1491	0.26
chr9_55253735_55254087	0.37	Nrg4	neuregulin 4	11450	0.18
chr4_142337823_142337991	0.37	Gm13052	predicted gene 13052	8568	0.28
chr9_94083843_94084083	0.37	Gm5369	predicted gene 5369	55499	0.17
chr11_31722665_31722816	0.36	Gm38061	predicted gene, 38061	24092	0.2
chr19_12697110_12697264	0.36	Keg1	kidney expressed gene 1	1373	0.26
chr15_7135727_7135925	0.36	Lifr	LIF receptor alpha	4716	0.31
chr8_46511132_46511387	0.36	Acsl1	acyl-CoA synthetase long-chain family member 1	15527	0.15
chr10_31497285_31497485	0.36	Gm47687	predicted gene, 47687	45303	0.1
chr3_141502934_141503090	0.36	Unc5c	unc-5 netrin receptor C	37341	0.18
chr11_111998446_111998808	0.35	Gm11679	predicted gene 11679	44951	0.19
chr6_48542267_48542478	0.35	Atp6v0e2	ATPase, H+ transporting, lysosomal V0 subunit E2	4707	0.08
chr2_131345745_131345918	0.34	Rnf24	ring finger protein 24	7031	0.14
chr7_119670801_119670968	0.34	Acsm4	acyl-CoA synthetase medium-chain family member 4	19142	0.1
chr8_12897974_12898151	0.34	Gm15353	predicted gene 15353	14336	0.11
chr4_83418470_83418621	0.34	Snapc3	small nuclear RNA activating complex, polypeptide 3	796	0.58
chr2_49177399_49177550	0.34	Gm13510	predicted gene 13510	7544	0.27
chr8_73938665_73938983	0.34	Gm7948	predicted gene 7948	67131	0.14
chr8_42183376_42183557	0.33	Gm6180	predicted pseudogene 6180	63445	0.14
chr19_55260521_55260708	0.33	Acsl5	acyl-CoA synthetase long-chain family member 5	7245	0.18
chr10_20010162_20010316	0.33	Map3k5	mitogen-activated protein kinase kinase kinase 5	59184	0.12
chr1_3586531_3586701	0.33	Gm38148	predicted gene, 38148	9287	0.19
chr8_70207953_70208123	0.33	Slc25a42	solute carrier family 25, member 42	4218	0.12
chr11_44518397_44518764	0.33	Rnf145	ring finger protein 145	384	0.85
chr3_138290241_138291213	0.33	Adh1	alcohol dehydrogenase 1 (class I)	13076	0.11
chr16_44137078_44137229	0.33	Atp6v1a	ATPase, H+ transporting, lysosomal V1 subunit A	1827	0.3
chr15_4678897_4679270	0.33	C6	complement component 6	48092	0.17
chr5_123091308_123091459	0.33	Tmem120b	transmembrane protein 120B	8518	0.09
chr9_53192914_53193065	0.33	Gm47986	predicted gene, 47986	28801	0.18
chr2_135855339_135855516	0.32	Plcb4	phospholipase C, beta 4	32267	0.19
chr16_43323583_43323748	0.32	Gm15711	predicted gene 15711	11071	0.17
chr8_114663169_114663337	0.32	Gm16117	predicted gene 16117	21139	0.19
chr10_68102616_68102812	0.32	Arid5b	AT rich interactive domain 5B (MRF1-like)	33912	0.17
chr8_107311781_107311960	0.32	Nfat5	nuclear factor of activated T cells 5	18311	0.18
chr3_84647383_84647687	0.32	Tmem154	transmembrane protein 154	18657	0.2
chr5_17280342_17280505	0.32	Gm6673	predicted gene 6673	52489	0.15
chr7_28959292_28959443	0.32	Actn4	actinin alpha 4	2856	0.14
chr2_27710029_27710632	0.32	Rxra	retinoid X receptor alpha	253	0.95
chr12_80837168_80837319	0.32	Susd6	sushi domain containing 6	31465	0.12
chr6_108281132_108281339	0.31	Itpr1	inositol 1,4,5-trisphosphate receptor 1	28277	0.22
chr10_75892623_75892818	0.31	Derl3	Der1-like domain family, member 3	693	0.47
chr17_34852319_34852771	0.31	Nelfe	negative elongation factor complex member E, Rdbp	63	0.89
chr9_44946661_44946812	0.31	Gm19121	predicted gene, 19121	8979	0.08
chr6_101326488_101326738	0.31	Gm43953	predicted gene, 43953	1592	0.32
chr10_24923327_24923737	0.31	Arg1	arginase, liver	3905	0.16
chr9_122149132_122149346	0.30	Gm47121	predicted gene, 47121	6790	0.13
chr4_124431592_124431891	0.30	1700057H15Rik	RIKEN cDNA 1700057H15 gene	12883	0.21
chr11_11845100_11845416	0.30	Ddc	dopa decarboxylase	8978	0.18
chr4_48909780_48909970	0.30	Gm12436	predicted gene 12436	11282	0.2
chr4_63267695_63267867	0.30	Mir455	microRNA 455	10930	0.16
chr9_9173231_9173382	0.30	Gm16833	predicted gene, 16833	62982	0.13
chr5_117364085_117364236	0.30	Wsb2	WD repeat and SOCS box-containing 2	638	0.56
chr11_110249489_110249640	0.30	Abca6	ATP-binding cassette, sub-family A (ABC1), member 6	2212	0.39
chr17_26253883_26254034	0.30	Luc7l	Luc7-like	736	0.39
chr19_43811775_43811943	0.30	Abcc2	ATP-binding cassette, sub-family C (CFTR/MRP), member 2	1337	0.38
chr7_123642615_123642780	0.30	Zkscan2	zinc finger with KRAB and SCAN domains 2	142248	0.04
chr3_87001052_87001203	0.30	Cd1d1	CD1d1 antigen	1686	0.28
chr6_5176021_5176208	0.30	Pon1	paraoxonase 1	17649	0.18
chr1_130877275_130877426	0.30	Fcmr	Fc fragment of IgM receptor	808	0.52
chr10_19946542_19946693	0.30	Map3k5	mitogen-activated protein kinase kinase kinase 5	4438	0.24
chr4_96662396_96662547	0.30	Cyp2j5	cytochrome P450, family 2, subfamily j, polypeptide 5	1683	0.46
chr1_139780384_139780535	0.30	Gm4788	predicted gene 4788	709	0.69
chr17_47976252_47976712	0.29	Gm14871	predicted gene 14871	27090	0.11
chr11_7815566_7815774	0.29	Gm27393	predicted gene, 27393	70835	0.13
chr6_28471887_28472038	0.29	Snd1	staphylococcal nuclease and tudor domain containing 1	3177	0.17
chr9_72702491_72702671	0.29	Nedd4	neural precursor cell expressed, developmentally down-regulated 4	9142	0.1
chr1_133650504_133650728	0.29	Zc3h11a	zinc finger CCCH type containing 11A	10665	0.13
chr18_69393942_69394102	0.29	Tcf4	transcription factor 4	21875	0.25
chr10_40446168_40446390	0.29	Cdk19os	cyclin-dependent kinase 19, opposite strand	96176	0.05
chr5_148633016_148633167	0.29	Gm29815	predicted gene, 29815	19447	0.18
chr5_17963645_17963839	0.29	Gnat3	guanine nucleotide binding protein, alpha transducing 3	1193	0.63
chr16_49857039_49857216	0.29	Cd47	CD47 antigen (Rh-related antigen, integrin-associated signal transducer)	1340	0.56
chr19_4772512_4772663	0.29	Gm37206	predicted gene, 37206	7416	0.09
chr8_36280569_36280720	0.28	Lonrf1	LON peptidase N-terminal domain and ring finger 1	31128	0.17
chr8_5030377_5030626	0.28	n-R5s93	nuclear encoded rRNA 5S 93	38876	0.14
chr5_8164154_8164307	0.28	Gm21759	predicted gene, 21759	15406	0.17
chr4_53222171_53222454	0.28	4930412L05Rik	RIKEN cDNA 4930412L05 gene	4455	0.21
chr18_32559226_32559588	0.28	Gypc	glycophorin C	573	0.78
chr6_147664470_147664629	0.28	1700049E15Rik	RIKEN cDNA 1700049E15 gene	25692	0.21
chr11_26684255_26684421	0.28	Gm12071	predicted gene 12071	28567	0.2
chr14_17914680_17914831	0.28	Thrb	thyroid hormone receptor beta	48066	0.16
chr9_68827763_68827979	0.28	Rora	RAR-related orphan receptor alpha	172568	0.03
chr13_109635481_109635828	0.28	Pde4d	phosphodiesterase 4D, cAMP specific	2874	0.42
chr16_95141907_95142069	0.28	Gm49642	predicted gene, 49642	29522	0.18
chr16_59413660_59413813	0.28	Gabrr3	gamma-aminobutyric acid (GABA) receptor, rho 3	6404	0.16
chr19_55719676_55719857	0.28	Tcf7l2	transcription factor 7 like 2, T cell specific, HMG box	22054	0.26
chr1_69801581_69801779	0.28	Spag16	sperm associated antigen 16	25290	0.2
chr1_151689614_151690051	0.27	Fam129a	family with sequence similarity 129, member A	12665	0.21
chr9_71905527_71905697	0.27	Gm18821	predicted gene, 18821	3231	0.15
chr4_154143077_154143228	0.27	Wrap73	WD repeat containing, antisense to Trp73	743	0.5
chr12_86516484_86516661	0.27	Esrrb	estrogen related receptor, beta	12163	0.24
chr2_167843295_167843525	0.27	1200007C13Rik	RIKEN cDNA 1200007C13 gene	9764	0.16
chr7_30962949_30963144	0.27	Gm4673	predicted gene 4673	5637	0.07
chr10_68126588_68126805	0.27	Arid5b	AT rich interactive domain 5B (MRF1-like)	9930	0.25
chr3_98741469_98742014	0.27	Hsd3b3	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 3	11724	0.13
chr16_91618278_91618429	0.27	Dnajc28	DnaJ heat shock protein family (Hsp40) member C28	638	0.54
chr6_72511397_72511595	0.27	Sh2d6	SH2 domain containing 6	8519	0.13
chr13_35469616_35469777	0.27	Gm48704	predicted gene, 48704	74206	0.09
chr13_9073792_9074124	0.27	Gm36264	predicted gene, 36264	2493	0.23
chr1_23237656_23237879	0.27	Gm29506	predicted gene 29506	2094	0.23
chr12_40574426_40574700	0.27	Dock4	dedicator of cytokinesis 4	128227	0.05
chr5_65068578_65068729	0.27	Tmem156	transmembrane protein 156	22931	0.15
chr17_56105602_56105761	0.27	Plin4	perilipin 4	4121	0.1
chr1_16107096_16107247	0.27	Rdh10	retinol dehydrogenase 10 (all-trans)	1397	0.36
chr7_107699185_107699336	0.27	Ppfibp2	PTPRF interacting protein, binding protein 2 (liprin beta 2)	33949	0.12
chr3_67085309_67085464	0.27	Gm22295	predicted gene, 22295	29428	0.2
chr9_114857411_114857562	0.27	Cmtm8	CKLF-like MARVEL transmembrane domain containing 8	13330	0.16
chr1_6511141_6511292	0.27	St18	suppression of tumorigenicity 18	23885	0.22
chr2_163615957_163616108	0.26	Ttpal	tocopherol (alpha) transfer protein-like	4512	0.16
chr16_45987509_45987734	0.26	Plcxd2	phosphatidylinositol-specific phospholipase C, X domain containing 2	22597	0.14
chr4_43724876_43725040	0.26	Hrct1	histidine rich carboxyl terminus 1	2230	0.13
chr3_87620282_87621117	0.26	Arhgef11	Rho guanine nucleotide exchange factor (GEF) 11	1938	0.27
chr16_38273526_38273677	0.26	Nr1i2	nuclear receptor subfamily 1, group I, member 2	21223	0.13
chr5_138013172_138013323	0.26	Gm29127	predicted gene 29127	4172	0.1
chr9_77723756_77723924	0.26	Gm47790	predicted gene, 47790	6439	0.15
chr18_62095425_62095728	0.26	Gm41750	predicted gene, 41750	47042	0.14
chr18_7644384_7644571	0.26	Mpp7	membrane protein, palmitoylated 7 (MAGUK p55 subfamily member 7)	17611	0.21
chr15_10211684_10211835	0.26	Prlr	prolactin receptor	1706	0.5
chr3_157730079_157730297	0.26	Gm33466	predicted gene, 33466	3780	0.29
chr10_24227305_24227456	0.26	Moxd1	monooxygenase, DBH-like 1	3835	0.24
chr7_13637528_13637679	0.26	Zbed4-ps1	zinc finger, BED type containing 4, pseudogene 1	1504	0.32
chr8_93193292_93193577	0.26	Gm45909	predicted gene 45909	2076	0.23
chr10_31827348_31827499	0.26	Gm47704	predicted gene, 47704	40489	0.2
chr12_78209771_78209951	0.26	Gm6657	predicted gene 6657	8895	0.15
chr8_71676856_71677014	0.26	Jak3	Janus kinase 3	383	0.7
chr16_31933221_31933374	0.26	Gm49731	predicted gene, 49731	350	0.56
chr1_73935593_73935760	0.26	Tns1	tensin 1	4865	0.25
chr10_120247499_120247740	0.26	Llph	LLP homolog, long-term synaptic facilitation (Aplysia)	20433	0.12
chr1_190156909_190157060	0.26	Gm28172	predicted gene 28172	11686	0.18
chr2_160362942_160363707	0.26	Mafb	v-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian)	3741	0.3
chr9_106269146_106269548	0.26	Poc1a	POC1 centriolar protein A	11714	0.11
chr7_99985802_99985987	0.26	Rnf169	ring finger protein 169	5446	0.14
chr3_18140093_18140313	0.26	Gm23686	predicted gene, 23686	37422	0.16
chr17_56104602_56104753	0.26	Hdgfl2	HDGF like 2	5115	0.09
chr17_78915849_78916004	0.26	Cebpzos	CCAAT/enhancer binding protein (C/EBP), zeta, opposite strand	574	0.63
chr4_150709744_150709942	0.25	Gm16079	predicted gene 16079	31051	0.16
chr1_39594759_39594927	0.25	Gm5100	predicted gene 5100	3162	0.16
chr13_3889050_3889201	0.25	Net1	neuroepithelial cell transforming gene 1	1300	0.32
chr8_35212732_35212892	0.25	Gm34474	predicted gene, 34474	5826	0.16
chr16_43394836_43395188	0.25	Gm15713	predicted gene 15713	25184	0.16
chr10_67100073_67100416	0.25	Reep3	receptor accessory protein 3	3299	0.24
chr5_150593024_150593258	0.25	N4bp2l1	NEDD4 binding protein 2-like 1	628	0.52
chr3_35931210_35931361	0.25	Dcun1d1	DCN1, defective in cullin neddylation 1, domain containing 1 (S. cerevisiae)	173	0.9
chrX_85828106_85828330	0.25	Gm14762	predicted gene 14762	1557	0.31
chr10_77629279_77629435	0.25	Ube2g2	ubiquitin-conjugating enzyme E2G 2	6979	0.08

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of Sox17

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.6	GO:0060528	secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development(GO:0060528)
0.1	0.4	GO:0006068	ethanol catabolic process(GO:0006068)
0.1	0.4	GO:1901078	negative regulation of relaxation of muscle(GO:1901078)
0.1	0.4	GO:0051081	membrane disassembly(GO:0030397) nuclear envelope disassembly(GO:0051081)
0.1	0.5	GO:0006549	isoleucine metabolic process(GO:0006549)
0.1	0.4	GO:0034755	iron ion transmembrane transport(GO:0034755)
0.1	0.3	GO:0032489	regulation of Cdc42 protein signal transduction(GO:0032489)
0.1	0.2	GO:0070672	response to interleukin-15(GO:0070672)
0.1	0.2	GO:0021524	visceral motor neuron differentiation(GO:0021524)
0.1	0.2	GO:0010909	regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010908) positive regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010909) positive regulation of proteoglycan biosynthetic process(GO:1902730)
0.1	0.3	GO:0003383	apical constriction(GO:0003383)
0.1	0.4	GO:0006526	arginine biosynthetic process(GO:0006526)
0.1	0.2	GO:0070949	regulation of neutrophil mediated cytotoxicity(GO:0070948) regulation of neutrophil mediated killing of symbiont cell(GO:0070949)
0.1	0.1	GO:0038161	prolactin signaling pathway(GO:0038161)
0.1	0.2	GO:0001831	trophectodermal cellular morphogenesis(GO:0001831)
0.1	0.2	GO:0048239	negative regulation of DNA recombination at telomere(GO:0048239) regulation of DNA recombination at telomere(GO:0072695)
0.1	0.2	GO:0001998	angiotensin mediated vasoconstriction involved in regulation of systemic arterial blood pressure(GO:0001998)
0.1	0.3	GO:0071763	nuclear membrane organization(GO:0071763)
0.1	0.2	GO:1900169	regulation of glucocorticoid mediated signaling pathway(GO:1900169)
0.1	0.2	GO:2001013	epithelial cell proliferation involved in renal tubule morphogenesis(GO:2001013)
0.1	0.2	GO:0045404	positive regulation of interleukin-4 biosynthetic process(GO:0045404)
0.1	0.3	GO:0050882	voluntary musculoskeletal movement(GO:0050882)
0.0	0.1	GO:0010481	epidermal cell division(GO:0010481) regulation of epidermal cell division(GO:0010482)
0.0	0.1	GO:2000211	regulation of glutamate metabolic process(GO:2000211)
0.0	0.1	GO:0032483	regulation of Rab protein signal transduction(GO:0032483)
0.0	0.3	GO:0015074	DNA integration(GO:0015074)
0.0	0.1	GO:1990314	cellular response to insulin-like growth factor stimulus(GO:1990314)
0.0	0.2	GO:0048478	replication fork protection(GO:0048478)
0.0	0.2	GO:0008228	opsonization(GO:0008228)
0.0	0.2	GO:2000741	positive regulation of mesenchymal stem cell differentiation(GO:2000741)
0.0	0.2	GO:0032819	positive regulation of natural killer cell proliferation(GO:0032819)
0.0	0.1	GO:0032383	regulation of intracellular lipid transport(GO:0032377) regulation of intracellular sterol transport(GO:0032380) regulation of intracellular cholesterol transport(GO:0032383)
0.0	0.2	GO:0006003	fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.0	0.1	GO:0098700	aminergic neurotransmitter loading into synaptic vesicle(GO:0015842) neurotransmitter loading into synaptic vesicle(GO:0098700)
0.0	0.0	GO:0006069	ethanol metabolic process(GO:0006067) ethanol oxidation(GO:0006069)
0.0	0.1	GO:0038165	oncostatin-M-mediated signaling pathway(GO:0038165)
0.0	0.1	GO:1902083	negative regulation of peptidyl-cysteine S-nitrosylation(GO:1902083)
0.0	0.2	GO:0044829	positive regulation by host of viral genome replication(GO:0044829)
0.0	0.1	GO:0046271	phenylpropanoid catabolic process(GO:0046271)
0.0	0.1	GO:0007621	negative regulation of female receptivity(GO:0007621)
0.0	0.1	GO:0045950	negative regulation of mitotic recombination(GO:0045950)
0.0	0.1	GO:0010963	regulation of L-arginine import(GO:0010963)
0.0	0.3	GO:1900364	negative regulation of mRNA polyadenylation(GO:1900364)
0.0	0.1	GO:2000870	regulation of progesterone secretion(GO:2000870)
0.0	0.1	GO:0007403	glial cell fate determination(GO:0007403)
0.0	0.1	GO:0045963	negative regulation of catecholamine metabolic process(GO:0045914) negative regulation of dopamine metabolic process(GO:0045963)
0.0	0.1	GO:0048382	mesendoderm development(GO:0048382)
0.0	0.1	GO:0021747	cochlear nucleus development(GO:0021747)
0.0	0.1	GO:0006166	purine ribonucleoside salvage(GO:0006166)
0.0	0.1	GO:0021699	cerebellar cortex maturation(GO:0021699)
0.0	0.4	GO:0009404	toxin metabolic process(GO:0009404)
0.0	0.1	GO:0006982	response to lipid hydroperoxide(GO:0006982)
0.0	0.2	GO:0033211	adiponectin-activated signaling pathway(GO:0033211)
0.0	0.1	GO:0006432	phenylalanyl-tRNA aminoacylation(GO:0006432)
0.0	0.1	GO:0034310	primary alcohol catabolic process(GO:0034310)
0.0	0.1	GO:2000017	positive regulation of determination of dorsal identity(GO:2000017)
0.0	0.1	GO:1901503	ether lipid biosynthetic process(GO:0008611) glycerol ether biosynthetic process(GO:0046504) cellular lipid biosynthetic process(GO:0097384) ether biosynthetic process(GO:1901503)
0.0	0.1	GO:1900042	positive regulation of interleukin-2 secretion(GO:1900042)
0.0	0.1	GO:0031848	protection from non-homologous end joining at telomere(GO:0031848)
0.0	0.1	GO:0060414	aorta smooth muscle tissue morphogenesis(GO:0060414)
0.0	0.1	GO:1900245	positive regulation of MDA-5 signaling pathway(GO:1900245)
0.0	0.1	GO:0002434	immune complex clearance(GO:0002434)
0.0	0.1	GO:1904502	regulation of lipophagy(GO:1904502) positive regulation of lipophagy(GO:1904504)
0.0	0.1	GO:0097112	gamma-aminobutyric acid receptor clustering(GO:0097112)
0.0	0.1	GO:2000587	regulation of platelet-derived growth factor receptor-beta signaling pathway(GO:2000586) negative regulation of platelet-derived growth factor receptor-beta signaling pathway(GO:2000587)
0.0	0.1	GO:0015744	succinate transport(GO:0015744)
0.0	0.1	GO:0045875	negative regulation of sister chromatid cohesion(GO:0045875)
0.0	0.2	GO:1904153	negative regulation of protein exit from endoplasmic reticulum(GO:0070862) negative regulation of retrograde protein transport, ER to cytosol(GO:1904153)
0.0	0.2	GO:0042118	endothelial cell activation(GO:0042118)
0.0	0.0	GO:0021590	cerebellum maturation(GO:0021590)
0.0	0.1	GO:0003431	growth plate cartilage chondrocyte development(GO:0003431)
0.0	0.1	GO:0019805	quinolinate biosynthetic process(GO:0019805)
0.0	0.1	GO:1902564	negative regulation of neutrophil activation(GO:1902564)
0.0	0.1	GO:0035461	vitamin transmembrane transport(GO:0035461)
0.0	0.1	GO:0006543	glutamine catabolic process(GO:0006543)
0.0	0.1	GO:0007412	axon target recognition(GO:0007412)
0.0	0.1	GO:0038128	ERBB2 signaling pathway(GO:0038128)
0.0	0.0	GO:1900363	regulation of mRNA polyadenylation(GO:1900363)
0.0	0.1	GO:0060431	primary lung bud formation(GO:0060431)
0.0	0.1	GO:0072602	interleukin-4 secretion(GO:0072602)
0.0	0.1	GO:0006477	protein sulfation(GO:0006477)
0.0	0.1	GO:1902414	protein localization to cell junction(GO:1902414)
0.0	0.1	GO:0050747	positive regulation of lipoprotein metabolic process(GO:0050747)
0.0	0.1	GO:0045218	zonula adherens maintenance(GO:0045218)
0.0	0.2	GO:1902170	cellular response to reactive nitrogen species(GO:1902170)
0.0	0.2	GO:1902857	positive regulation of nonmotile primary cilium assembly(GO:1902857)
0.0	0.0	GO:0021550	medulla oblongata development(GO:0021550)
0.0	0.1	GO:1901859	negative regulation of mitochondrial DNA metabolic process(GO:1901859)
0.0	0.0	GO:0014732	skeletal muscle atrophy(GO:0014732)
0.0	0.1	GO:0097118	neuroligin clustering involved in postsynaptic membrane assembly(GO:0097118)
0.0	0.1	GO:0030423	targeting of mRNA for destruction involved in RNA interference(GO:0030423)
0.0	0.1	GO:0048619	embryonic hindgut morphogenesis(GO:0048619)
0.0	0.1	GO:0009235	cobalamin metabolic process(GO:0009235)
0.0	0.1	GO:0061341	non-canonical Wnt signaling pathway involved in heart development(GO:0061341) planar cell polarity pathway involved in heart morphogenesis(GO:0061346)
0.0	0.0	GO:1904742	regulation of telomeric DNA binding(GO:1904742)
0.0	0.1	GO:0018317	protein C-linked glycosylation(GO:0018103) peptidyl-tryptophan modification(GO:0018211) protein C-linked glycosylation via tryptophan(GO:0018317) protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan(GO:0018406)
0.0	0.0	GO:0035622	intrahepatic bile duct development(GO:0035622)
0.0	0.1	GO:0001920	negative regulation of receptor recycling(GO:0001920)
0.0	0.1	GO:0070375	ERK5 cascade(GO:0070375)
0.0	0.1	GO:0010606	positive regulation of cytoplasmic mRNA processing body assembly(GO:0010606)
0.0	0.1	GO:1905206	positive regulation of hydrogen peroxide-mediated programmed cell death(GO:1901300) positive regulation of hydrogen peroxide-induced cell death(GO:1905206)
0.0	0.1	GO:0031585	regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0031585)
0.0	0.1	GO:0048143	astrocyte activation(GO:0048143)
0.0	0.0	GO:0010534	regulation of activation of JAK2 kinase activity(GO:0010534)
0.0	0.1	GO:0035795	negative regulation of mitochondrial membrane permeability(GO:0035795)
0.0	0.0	GO:1903371	regulation of endoplasmic reticulum tubular network organization(GO:1903371)
0.0	0.1	GO:0021571	rhombomere 5 development(GO:0021571)
0.0	0.1	GO:0060665	regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling(GO:0060665)
0.0	0.1	GO:1902915	negative regulation of protein K63-linked ubiquitination(GO:1900045) negative regulation of protein polyubiquitination(GO:1902915)
0.0	0.1	GO:0050916	sensory perception of sweet taste(GO:0050916)
0.0	0.1	GO:0070236	negative regulation of activation-induced cell death of T cells(GO:0070236)
0.0	0.1	GO:0072367	regulation of lipid transport by regulation of transcription from RNA polymerase II promoter(GO:0072367)
0.0	0.0	GO:1900186	negative regulation of clathrin-mediated endocytosis(GO:1900186)
0.0	0.1	GO:1902268	negative regulation of polyamine transmembrane transport(GO:1902268)
0.0	0.1	GO:0033353	S-adenosylmethionine cycle(GO:0033353)
0.0	0.1	GO:0009629	response to gravity(GO:0009629)
0.0	0.1	GO:0090205	positive regulation of cholesterol biosynthetic process(GO:0045542) positive regulation of cholesterol metabolic process(GO:0090205)
0.0	0.1	GO:0030327	prenylated protein catabolic process(GO:0030327)
0.0	0.1	GO:0033601	positive regulation of mammary gland epithelial cell proliferation(GO:0033601)
0.0	0.1	GO:0090666	scaRNA localization to Cajal body(GO:0090666)
0.0	0.2	GO:0045116	protein neddylation(GO:0045116)
0.0	0.1	GO:0071316	cellular response to nicotine(GO:0071316)
0.0	0.2	GO:0055064	chloride ion homeostasis(GO:0055064)
0.0	0.2	GO:0001867	complement activation, lectin pathway(GO:0001867)
0.0	0.1	GO:0035336	long-chain fatty-acyl-CoA metabolic process(GO:0035336)
0.0	0.1	GO:0033564	anterior/posterior axon guidance(GO:0033564)
0.0	0.1	GO:0007023	post-chaperonin tubulin folding pathway(GO:0007023)
0.0	0.0	GO:0046100	hypoxanthine metabolic process(GO:0046100) hypoxanthine biosynthetic process(GO:0046101)
0.0	0.1	GO:0051387	negative regulation of neurotrophin TRK receptor signaling pathway(GO:0051387)
0.0	0.1	GO:0045650	negative regulation of macrophage differentiation(GO:0045650)
0.0	0.1	GO:0042732	D-xylose metabolic process(GO:0042732)
0.0	0.0	GO:0006842	tricarboxylic acid transport(GO:0006842) citrate transport(GO:0015746)
0.0	0.1	GO:0016554	cytidine to uridine editing(GO:0016554)
0.0	0.1	GO:0042795	snRNA transcription from RNA polymerase II promoter(GO:0042795)
0.0	0.2	GO:0006517	protein deglycosylation(GO:0006517)
0.0	0.1	GO:0010642	negative regulation of platelet-derived growth factor receptor signaling pathway(GO:0010642)
0.0	0.0	GO:0032741	positive regulation of interleukin-18 production(GO:0032741)
0.0	0.1	GO:0060613	fat pad development(GO:0060613)
0.0	0.0	GO:2000409	positive regulation of T cell extravasation(GO:2000409)
0.0	0.0	GO:0006391	transcription initiation from mitochondrial promoter(GO:0006391)
0.0	0.1	GO:0021540	corpus callosum morphogenesis(GO:0021540)
0.0	0.0	GO:0090110	cargo loading into COPII-coated vesicle(GO:0090110)
0.0	0.0	GO:0005984	disaccharide metabolic process(GO:0005984)
0.0	0.0	GO:2000259	positive regulation of complement activation(GO:0045917) positive regulation of protein activation cascade(GO:2000259)
0.0	0.1	GO:1902018	negative regulation of cilium assembly(GO:1902018)
0.0	0.0	GO:2000646	positive regulation of receptor catabolic process(GO:2000646)
0.0	0.0	GO:1904694	negative regulation of vascular smooth muscle contraction(GO:1904694)
0.0	0.0	GO:0042360	vitamin E metabolic process(GO:0042360)
0.0	0.0	GO:0003358	noradrenergic neuron development(GO:0003358)
0.0	0.0	GO:1904469	positive regulation of tumor necrosis factor secretion(GO:1904469)
0.0	0.0	GO:0032482	Rab protein signal transduction(GO:0032482)
0.0	0.0	GO:1903626	positive regulation of apoptotic DNA fragmentation(GO:1902512) positive regulation of DNA catabolic process(GO:1903626)
0.0	0.2	GO:0009143	nucleoside triphosphate catabolic process(GO:0009143)
0.0	0.1	GO:1903887	motile primary cilium assembly(GO:1903887)
0.0	0.1	GO:0090209	negative regulation of triglyceride metabolic process(GO:0090209)
0.0	0.0	GO:0071638	negative regulation of monocyte chemotactic protein-1 production(GO:0071638)
0.0	0.0	GO:0043490	malate-aspartate shuttle(GO:0043490)
0.0	0.0	GO:1990168	protein K29-linked deubiquitination(GO:0035523) protein K33-linked deubiquitination(GO:1990168)
0.0	0.1	GO:2001286	regulation of caveolin-mediated endocytosis(GO:2001286)
0.0	0.1	GO:0035519	protein K29-linked ubiquitination(GO:0035519)
0.0	0.0	GO:0036438	maintenance of lens transparency(GO:0036438)
0.0	0.1	GO:0031033	myosin filament organization(GO:0031033)
0.0	0.0	GO:0042518	negative regulation of tyrosine phosphorylation of Stat3 protein(GO:0042518)
0.0	0.0	GO:0035935	androgen secretion(GO:0035935) regulation of androgen secretion(GO:2000834) positive regulation of androgen secretion(GO:2000836)
0.0	0.1	GO:0000436	carbon catabolite regulation of transcription from RNA polymerase II promoter(GO:0000429) carbon catabolite activation of transcription from RNA polymerase II promoter(GO:0000436)
0.0	0.0	GO:1901679	nucleotide transmembrane transport(GO:1901679)
0.0	0.0	GO:0007084	mitotic nuclear envelope reassembly(GO:0007084)
0.0	0.0	GO:0031086	nuclear-transcribed mRNA catabolic process, deadenylation-independent decay(GO:0031086) deadenylation-independent decapping of nuclear-transcribed mRNA(GO:0031087)
0.0	0.0	GO:1900242	regulation of synaptic vesicle endocytosis(GO:1900242)
0.0	0.0	GO:1902309	negative regulation of peptidyl-serine dephosphorylation(GO:1902309)
0.0	0.0	GO:1900425	negative regulation of defense response to bacterium(GO:1900425)
0.0	0.1	GO:0031468	nuclear envelope reassembly(GO:0031468)
0.0	0.1	GO:0006123	mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.0	0.0	GO:0001777	T cell homeostatic proliferation(GO:0001777) regulation of T cell homeostatic proliferation(GO:0046013)
0.0	0.0	GO:0002681	somatic diversification of T cell receptor genes(GO:0002568) somatic recombination of T cell receptor gene segments(GO:0002681) T cell receptor V(D)J recombination(GO:0033153)
0.0	0.0	GO:0045897	regulation of transcription during mitosis(GO:0045896) positive regulation of transcription during mitosis(GO:0045897)
0.0	0.1	GO:0010875	positive regulation of cholesterol efflux(GO:0010875)
0.0	0.0	GO:0090148	membrane fission(GO:0090148)
0.0	0.0	GO:0031627	telomeric loop formation(GO:0031627)
0.0	0.0	GO:0000960	mitochondrial RNA catabolic process(GO:0000957) regulation of mitochondrial RNA catabolic process(GO:0000960)
0.0	0.1	GO:0046085	adenosine metabolic process(GO:0046085)
0.0	0.2	GO:0000301	retrograde transport, vesicle recycling within Golgi(GO:0000301)
0.0	0.3	GO:0006376	mRNA splice site selection(GO:0006376)
0.0	0.0	GO:1901097	negative regulation of autophagosome maturation(GO:1901097)
0.0	0.0	GO:0002727	natural killer cell cytokine production(GO:0002370) regulation of natural killer cell cytokine production(GO:0002727)
0.0	0.1	GO:0006654	phosphatidic acid biosynthetic process(GO:0006654)
0.0	0.1	GO:0000183	chromatin silencing at rDNA(GO:0000183)
0.0	0.0	GO:0070669	response to interleukin-2(GO:0070669)
0.0	0.0	GO:0006041	glucosamine metabolic process(GO:0006041)
0.0	0.1	GO:0051987	positive regulation of attachment of spindle microtubules to kinetochore(GO:0051987)
0.0	0.1	GO:0006120	mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.0	0.0	GO:0006499	N-terminal protein myristoylation(GO:0006499)
0.0	0.1	GO:0070874	negative regulation of glycogen metabolic process(GO:0070874)
0.0	0.0	GO:1900095	regulation of dosage compensation by inactivation of X chromosome(GO:1900095)
0.0	0.1	GO:0006002	fructose 6-phosphate metabolic process(GO:0006002)
0.0	0.1	GO:0051451	myoblast migration(GO:0051451)
0.0	0.0	GO:0060501	positive regulation of epithelial cell proliferation involved in lung morphogenesis(GO:0060501)
0.0	0.0	GO:0006933	negative regulation of cell adhesion involved in substrate-bound cell migration(GO:0006933)
0.0	0.2	GO:0006465	signal peptide processing(GO:0006465)
0.0	0.1	GO:0051549	regulation of keratinocyte migration(GO:0051547) positive regulation of keratinocyte migration(GO:0051549)
0.0	0.0	GO:0034241	positive regulation of macrophage fusion(GO:0034241)
0.0	0.0	GO:2000664	positive regulation of interleukin-5 secretion(GO:2000664) positive regulation of interleukin-13 secretion(GO:2000667)
0.0	0.0	GO:0070601	centromeric sister chromatid cohesion(GO:0070601)
0.0	0.1	GO:0001547	antral ovarian follicle growth(GO:0001547)
0.0	0.0	GO:2000370	positive regulation of clathrin-mediated endocytosis(GO:2000370)
0.0	0.1	GO:0051601	exocyst localization(GO:0051601)
0.0	0.0	GO:0006106	fumarate metabolic process(GO:0006106)
0.0	0.1	GO:0006614	SRP-dependent cotranslational protein targeting to membrane(GO:0006614)
0.0	0.2	GO:0019432	triglyceride biosynthetic process(GO:0019432)
0.0	0.1	GO:0046831	regulation of RNA export from nucleus(GO:0046831)
0.0	0.1	GO:0003334	keratinocyte development(GO:0003334)
0.0	0.0	GO:0016557	peroxisome membrane biogenesis(GO:0016557)
0.0	0.1	GO:0042536	negative regulation of tumor necrosis factor biosynthetic process(GO:0042536)
0.0	0.0	GO:0044314	protein K27-linked ubiquitination(GO:0044314)
0.0	0.0	GO:0000019	regulation of mitotic recombination(GO:0000019)
0.0	0.1	GO:0000244	spliceosomal tri-snRNP complex assembly(GO:0000244)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.4	GO:0060053	neurofilament cytoskeleton(GO:0060053)
0.1	0.3	GO:0032021	NELF complex(GO:0032021)
0.1	0.2	GO:1990907	beta-catenin-TCF complex(GO:1990907)
0.1	0.2	GO:0031088	platelet dense granule membrane(GO:0031088)
0.1	0.3	GO:0033269	internode region of axon(GO:0033269)
0.1	0.2	GO:1990604	IRE1-TRAF2-ASK1 complex(GO:1990604)
0.0	0.1	GO:0042583	chromaffin granule(GO:0042583)
0.0	0.1	GO:0005827	polar microtubule(GO:0005827)
0.0	0.1	GO:0036449	microtubule minus-end(GO:0036449)
0.0	0.1	GO:0070545	PeBoW complex(GO:0070545)
0.0	0.1	GO:0097025	MPP7-DLG1-LIN7 complex(GO:0097025)
0.0	0.1	GO:0042567	insulin-like growth factor binding protein complex(GO:0016942) growth factor complex(GO:0036454) insulin-like growth factor ternary complex(GO:0042567)
0.0	0.1	GO:0044615	nuclear pore nuclear basket(GO:0044615)
0.0	0.1	GO:0008091	spectrin(GO:0008091)
0.0	0.1	GO:0044308	axonal spine(GO:0044308)
0.0	0.2	GO:0000783	telomere cap complex(GO:0000782) nuclear telomere cap complex(GO:0000783)
0.0	0.1	GO:0031315	extrinsic component of mitochondrial outer membrane(GO:0031315)
0.0	0.3	GO:0000930	gamma-tubulin complex(GO:0000930)
0.0	0.0	GO:0033186	CAF-1 complex(GO:0033186)
0.0	0.1	GO:0030891	VCB complex(GO:0030891)
0.0	0.1	GO:0032541	cortical endoplasmic reticulum(GO:0032541)
0.0	0.1	GO:0000137	Golgi cis cisterna(GO:0000137)
0.0	0.3	GO:0032588	trans-Golgi network membrane(GO:0032588)
0.0	0.2	GO:0035098	ESC/E(Z) complex(GO:0035098)
0.0	0.1	GO:0097433	dense body(GO:0097433)
0.0	0.1	GO:0005952	cAMP-dependent protein kinase complex(GO:0005952)
0.0	0.1	GO:0000942	condensed nuclear chromosome outer kinetochore(GO:0000942)
0.0	0.1	GO:0033256	I-kappaB/NF-kappaB complex(GO:0033256)
0.0	0.1	GO:1990716	axonemal central apparatus(GO:1990716)
0.0	0.1	GO:0005915	zonula adherens(GO:0005915)
0.0	0.1	GO:0070033	synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex(GO:0070033)
0.0	0.0	GO:0097487	multivesicular body, internal vesicle(GO:0097487)
0.0	0.1	GO:1990130	Iml1 complex(GO:1990130)
0.0	0.1	GO:0070688	MLL5-L complex(GO:0070688)
0.0	0.0	GO:0005899	insulin receptor complex(GO:0005899)
0.0	0.2	GO:0031907	peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.0	0.1	GO:0070419	nonhomologous end joining complex(GO:0070419)
0.0	0.0	GO:0005745	m-AAA complex(GO:0005745)
0.0	0.2	GO:0071004	U2-type prespliceosome(GO:0071004)
0.0	0.1	GO:0031415	NatA complex(GO:0031415)
0.0	0.1	GO:0046581	intercellular canaliculus(GO:0046581)
0.0	0.0	GO:0033553	rDNA heterochromatin(GO:0033553)
0.0	0.0	GO:0072357	PTW/PP1 phosphatase complex(GO:0072357)
0.0	0.1	GO:0031467	Cul7-RING ubiquitin ligase complex(GO:0031467)
0.0	0.0	GO:0036488	CHOP-C/EBP complex(GO:0036488)
0.0	0.1	GO:0005751	mitochondrial respiratory chain complex IV(GO:0005751)
0.0	0.0	GO:0000214	tRNA-intron endonuclease complex(GO:0000214)
0.0	0.0	GO:0045298	tubulin complex(GO:0045298)
0.0	0.1	GO:0042105	alpha-beta T cell receptor complex(GO:0042105)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	0.5	GO:0004886	9-cis retinoic acid receptor activity(GO:0004886)
0.1	0.4	GO:0004024	alcohol dehydrogenase activity, zinc-dependent(GO:0004024)
0.1	0.3	GO:0034186	apolipoprotein A-I binding(GO:0034186)
0.1	0.3	GO:0016743	carboxyl- or carbamoyltransferase activity(GO:0016743)
0.1	0.3	GO:0047961	glycine N-acyltransferase activity(GO:0047961)
0.1	0.2	GO:0005220	inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.1	0.2	GO:0035529	NADH pyrophosphatase activity(GO:0035529)
0.1	0.2	GO:0055100	adiponectin binding(GO:0055100)
0.1	0.2	GO:0004924	oncostatin-M receptor activity(GO:0004924)
0.0	0.1	GO:0102007	lactonohydrolase activity(GO:0046573) acyl-L-homoserine-lactone lactonohydrolase activity(GO:0102007)
0.0	0.0	GO:0015927	trehalase activity(GO:0015927)
0.0	0.1	GO:0000702	oxidized base lesion DNA N-glycosylase activity(GO:0000702)
0.0	0.2	GO:0071723	lipopeptide binding(GO:0071723)
0.0	0.1	GO:0036042	long-chain fatty acyl-CoA binding(GO:0036042)
0.0	0.2	GO:0004165	dodecenoyl-CoA delta-isomerase activity(GO:0004165)
0.0	0.1	GO:0004022	alcohol dehydrogenase (NAD) activity(GO:0004022)
0.0	0.1	GO:0004719	protein-L-isoaspartate (D-aspartate) O-methyltransferase activity(GO:0004719)
0.0	0.4	GO:0050308	sugar-phosphatase activity(GO:0050308)
0.0	0.3	GO:0005167	neurotrophin TRK receptor binding(GO:0005167)
0.0	0.2	GO:0004887	thyroid hormone receptor activity(GO:0004887)
0.0	0.3	GO:0004499	N,N-dimethylaniline monooxygenase activity(GO:0004499)
0.0	0.1	GO:0071532	ankyrin repeat binding(GO:0071532)
0.0	0.1	GO:0052650	NADP-retinol dehydrogenase activity(GO:0052650)
0.0	0.1	GO:0004096	catalase activity(GO:0004096)
0.0	0.3	GO:0097602	cullin family protein binding(GO:0097602)
0.0	0.1	GO:0004566	beta-glucuronidase activity(GO:0004566)
0.0	0.2	GO:0004908	interleukin-1 receptor activity(GO:0004908)
0.0	0.1	GO:0015141	succinate transmembrane transporter activity(GO:0015141)
0.0	0.2	GO:0005078	MAP-kinase scaffold activity(GO:0005078)
0.0	0.2	GO:0098505	G-rich strand telomeric DNA binding(GO:0098505)
0.0	0.1	GO:0004687	myosin light chain kinase activity(GO:0004687)
0.0	0.1	GO:0070053	thrombospondin receptor activity(GO:0070053)
0.0	0.1	GO:0004035	alkaline phosphatase activity(GO:0004035)
0.0	0.1	GO:0004013	adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.0	0.1	GO:0001069	regulatory region RNA binding(GO:0001069)
0.0	0.1	GO:0019158	fructokinase activity(GO:0008865) mannokinase activity(GO:0019158)
0.0	0.1	GO:0035373	chondroitin sulfate proteoglycan binding(GO:0035373)
0.0	0.1	GO:0004359	glutaminase activity(GO:0004359)
0.0	0.1	GO:0004769	steroid delta-isomerase activity(GO:0004769)
0.0	0.1	GO:0004826	phenylalanine-tRNA ligase activity(GO:0004826)
0.0	0.0	GO:0050816	phosphothreonine binding(GO:0050816)
0.0	0.1	GO:0009378	four-way junction helicase activity(GO:0009378)
0.0	0.0	GO:0004340	glucokinase activity(GO:0004340) hexokinase activity(GO:0004396)
0.0	0.1	GO:0005042	netrin receptor activity(GO:0005042)
0.0	0.1	GO:0098847	sequence-specific single stranded DNA binding(GO:0098847)
0.0	0.0	GO:0048408	epidermal growth factor binding(GO:0048408)
0.0	0.1	GO:0016899	oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor(GO:0016899)
0.0	0.1	GO:0016882	cyclo-ligase activity(GO:0016882)
0.0	0.3	GO:0045236	CXCR chemokine receptor binding(GO:0045236)
0.0	0.1	GO:0098821	BMP receptor activity(GO:0098821)
0.0	0.3	GO:0045295	gamma-catenin binding(GO:0045295)
0.0	0.1	GO:0050692	DBD domain binding(GO:0050692)
0.0	0.1	GO:0070548	L-glutamine aminotransferase activity(GO:0070548)
0.0	0.1	GO:0004679	AMP-activated protein kinase activity(GO:0004679)
0.0	0.1	GO:0000268	peroxisome targeting sequence binding(GO:0000268)
0.0	0.5	GO:0004117	calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117) cGMP-stimulated cyclic-nucleotide phosphodiesterase activity(GO:0004118) cGMP-inhibited cyclic-nucleotide phosphodiesterase activity(GO:0004119) photoreceptor cyclic-nucleotide phosphodiesterase activity(GO:0004120) 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate phosphodiesterase activity(GO:0044688) inositol phosphosphingolipid phospholipase activity(GO:0052712) inositol phosphorylceramide phospholipase activity(GO:0052713) mannosyl-inositol phosphorylceramide phospholipase activity(GO:0052714) mannosyl-diinositol phosphorylceramide phospholipase activity(GO:0052715)
0.0	0.1	GO:0000014	single-stranded DNA endodeoxyribonuclease activity(GO:0000014)
0.0	0.1	GO:0016716	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen(GO:0016716)
0.0	0.1	GO:0019153	protein-disulfide reductase (glutathione) activity(GO:0019153)
0.0	0.2	GO:0031386	protein tag(GO:0031386)
0.0	0.1	GO:0003986	acetyl-CoA hydrolase activity(GO:0003986)
0.0	0.1	GO:0051525	NFAT protein binding(GO:0051525)
0.0	0.1	GO:0004505	phenylalanine 4-monooxygenase activity(GO:0004505)
0.0	0.1	GO:0050733	RS domain binding(GO:0050733)
0.0	0.2	GO:0030898	actin-dependent ATPase activity(GO:0030898)
0.0	0.0	GO:0015142	citrate transmembrane transporter activity(GO:0015137) tricarboxylic acid transmembrane transporter activity(GO:0015142)
0.0	0.1	GO:0005025	transforming growth factor beta receptor activity, type I(GO:0005025)
0.0	0.2	GO:0034450	ubiquitin-ubiquitin ligase activity(GO:0034450)
0.0	0.5	GO:0008200	ion channel inhibitor activity(GO:0008200)
0.0	0.0	GO:0016909	JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.0	0.0	GO:0005347	ATP transmembrane transporter activity(GO:0005347)
0.0	0.1	GO:0016715	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen(GO:0016715)
0.0	0.1	GO:0004322	ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.0	0.1	GO:0004571	mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.0	0.1	GO:0005166	neurotrophin p75 receptor binding(GO:0005166)
0.0	0.0	GO:0019976	interleukin-2 binding(GO:0019976)
0.0	0.5	GO:0042169	SH2 domain binding(GO:0042169)
0.0	0.4	GO:0043014	alpha-tubulin binding(GO:0043014)
0.0	0.1	GO:0050815	phosphoserine binding(GO:0050815)
0.0	0.2	GO:0008349	MAP kinase kinase kinase kinase activity(GO:0008349)
0.0	0.1	GO:0031419	cobalamin binding(GO:0031419)
0.0	0.1	GO:0003917	DNA topoisomerase type I activity(GO:0003917)
0.0	0.1	GO:1990381	ubiquitin-specific protease binding(GO:1990381)
0.0	0.2	GO:1900750	glutathione binding(GO:0043295) oligopeptide binding(GO:1900750)
0.0	0.1	GO:0005047	signal recognition particle binding(GO:0005047)
0.0	0.1	GO:0003708	retinoic acid receptor activity(GO:0003708)
0.0	0.2	GO:0008253	5'-nucleotidase activity(GO:0008253)
0.0	0.0	GO:0097109	neuroligin family protein binding(GO:0097109)
0.0	0.2	GO:0005545	1-phosphatidylinositol binding(GO:0005545)
0.0	0.1	GO:0003846	2-acylglycerol O-acyltransferase activity(GO:0003846)
0.0	0.0	GO:0015556	C4-dicarboxylate transmembrane transporter activity(GO:0015556)
0.0	0.2	GO:0005452	inorganic anion exchanger activity(GO:0005452)
0.0	0.1	GO:0000828	inositol hexakisphosphate kinase activity(GO:0000828) inositol hexakisphosphate 5-kinase activity(GO:0000832) inositol hexakisphosphate 1-kinase activity(GO:0052723) inositol hexakisphosphate 3-kinase activity(GO:0052724)
0.0	0.0	GO:0018479	benzaldehyde dehydrogenase (NAD+) activity(GO:0018479)
0.0	0.1	GO:0008190	eukaryotic initiation factor 4E binding(GO:0008190)
0.0	0.2	GO:0017049	GTP-Rho binding(GO:0017049)
0.0	0.1	GO:0008494	translation activator activity(GO:0008494)
0.0	0.0	GO:0016286	small conductance calcium-activated potassium channel activity(GO:0016286)
0.0	0.0	GO:0015016	[heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.0	0.1	GO:0035005	1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.0	0.1	GO:0008568	microtubule-severing ATPase activity(GO:0008568)
0.0	0.0	GO:0052834	inositol monophosphate 1-phosphatase activity(GO:0008934) inositol monophosphate 3-phosphatase activity(GO:0052832) inositol monophosphate 4-phosphatase activity(GO:0052833) inositol monophosphate phosphatase activity(GO:0052834)
0.0	0.1	GO:0090079	translation regulator activity, nucleic acid binding(GO:0090079)
0.0	0.1	GO:0043495	protein anchor(GO:0043495)
0.0	0.0	GO:0001515	opioid peptide activity(GO:0001515)
0.0	0.0	GO:0097493	structural molecule activity conferring elasticity(GO:0097493)
0.0	0.1	GO:0008140	cAMP response element binding protein binding(GO:0008140)
0.0	0.1	GO:0004758	serine C-palmitoyltransferase activity(GO:0004758)
0.0	0.1	GO:0016151	nickel cation binding(GO:0016151)
0.0	0.1	GO:0050656	3'-phosphoadenosine 5'-phosphosulfate binding(GO:0050656)
0.0	0.0	GO:0016822	hydrolase activity, acting on acid carbon-carbon bonds(GO:0016822) hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances(GO:0016823)
0.0	0.0	GO:0008532	N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity(GO:0008532)
0.0	0.1	GO:0045322	unmethylated CpG binding(GO:0045322)
0.0	0.0	GO:0004062	aryl sulfotransferase activity(GO:0004062)
0.0	0.3	GO:0005547	phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.0	0.3	GO:0001205	transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.0	0.0	GO:0005006	epidermal growth factor-activated receptor activity(GO:0005006)
0.0	0.2	GO:0010485	H4 histone acetyltransferase activity(GO:0010485)
0.0	0.0	GO:0004937	alpha1-adrenergic receptor activity(GO:0004937)
0.0	0.1	GO:0047760	butyrate-CoA ligase activity(GO:0047760)
0.0	0.1	GO:0046790	virion binding(GO:0046790)
0.0	0.1	GO:0004535	poly(A)-specific ribonuclease activity(GO:0004535)
0.0	0.5	GO:0004559	alpha-mannosidase activity(GO:0004559)

Gene overrepresentation in curated gene sets: canonical pathways category:

Total log-likelihood	Term	Description
1.0	PID RXR VDR PATHWAY	RXR and RAR heterodimerization with other nuclear receptor
0.0	PID P38 GAMMA DELTA PATHWAY	Signaling mediated by p38-gamma and p38-delta
0.1	PID INTEGRIN3 PATHWAY	Beta3 integrin cell surface interactions
0.2	ST JAK STAT PATHWAY	Jak-STAT Pathway
0.5	PID LIS1 PATHWAY	Lissencephaly gene (LIS1) in neuronal migration and development
0.0	PID ANTHRAX PATHWAY	Cellular roles of Anthrax toxin
0.3	ST WNT CA2 CYCLIC GMP PATHWAY	Wnt/Ca2+/cyclic GMP signaling.
0.4	PID PI3K PLC TRK PATHWAY	Trk receptor signaling mediated by PI3K and PLC-gamma
0.4	ST GA13 PATHWAY	G alpha 13 Pathway
0.1	PID IGF1 PATHWAY	IGF1 pathway
0.3	PID IL23 PATHWAY	IL23-mediated signaling events
0.4	PID SHP2 PATHWAY	SHP2 signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.5	REACTOME PROLACTIN RECEPTOR SIGNALING	Genes involved in Prolactin receptor signaling
0.0	0.3	REACTOME ETHANOL OXIDATION	Genes involved in Ethanol oxidation
0.0	0.0	REACTOME MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS	Genes involved in Membrane binding and targetting of GAG proteins
0.0	0.2	REACTOME IL 7 SIGNALING	Genes involved in Interleukin-7 signaling
0.0	0.0	REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA HYDROXYCHOLESTEROL	Genes involved in Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
0.0	0.5	REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION	Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.0	0.1	REACTOME GLYCOLYSIS	Genes involved in Glycolysis
0.0	0.3	REACTOME HDL MEDIATED LIPID TRANSPORT	Genes involved in HDL-mediated lipid transport
0.0	0.2	REACTOME PURINE CATABOLISM	Genes involved in Purine catabolism
0.0	0.0	REACTOME ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION	Genes involved in activated TAK1 mediates p38 MAPK activation
0.0	0.2	REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS	Genes involved in ABCA transporters in lipid homeostasis
0.0	0.4	REACTOME DARPP 32 EVENTS	Genes involved in DARPP-32 events
0.0	0.2	REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS	Genes involved in Signal regulatory protein (SIRP) family interactions
0.0	0.2	REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION	Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.0	0.1	REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK	Genes involved in Regulation of Rheb GTPase activity by AMPK
0.0	0.0	REACTOME SIGNALLING BY NGF	Genes involved in Signalling by NGF
0.0	0.3	REACTOME GLUTATHIONE CONJUGATION	Genes involved in Glutathione conjugation
0.0	0.1	REACTOME NFKB IS ACTIVATED AND SIGNALS SURVIVAL	Genes involved in NF-kB is activated and signals survival
0.0	0.1	REACTOME BASE FREE SUGAR PHOSPHATE REMOVAL VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY	Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway
0.0	0.0	REACTOME DIGESTION OF DIETARY CARBOHYDRATE	Genes involved in Digestion of dietary carbohydrate
0.0	0.3	REACTOME PHASE II CONJUGATION	Genes involved in Phase II conjugation
0.0	0.0	REACTOME RNA POL I PROMOTER OPENING	Genes involved in RNA Polymerase I Promoter Opening
0.0	0.1	REACTOME METABOLISM OF PORPHYRINS	Genes involved in Metabolism of porphyrins
0.0	0.1	REACTOME NFKB ACTIVATION THROUGH FADD RIP1 PATHWAY MEDIATED BY CASPASE 8 AND10	Genes involved in NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
0.0	0.1	REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA	Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.0	0.1	REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT	Genes involved in ABC-family proteins mediated transport
0.0	0.4	REACTOME NRAGE SIGNALS DEATH THROUGH JNK	Genes involved in NRAGE signals death through JNK