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ENCSR904DTN: DNase-seq of mouse liver in constant darkness

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for Sox4

Z-value: 1.00

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Transcription factors associated with Sox4

Gene Symbol	Gene ID	Gene Info
Sox4 Ensembl NCBI MGI UniProt	ENSMUSG00000076431.4	Sox4

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

Gene	Promoter	Distance	Association probability	Pearson corr. coef.	P-value	Plot
Sox4	chr13_28930434_28930607	23193	0.167201	0.82	4.5e-02	Click!
Sox4	chr13_28958185_28958642	4700	0.246141	-0.80	5.8e-02	Click!
Sox4	chr13_28958754_28958905	5116	0.241122	-0.51	3.1e-01	Click!
Sox4	chr13_28953339_28953518	285	0.922547	-0.49	3.2e-01	Click!
Sox4	chr13_28957891_28958075	4270	0.252776	-0.41	4.2e-01	Click!

Activity of the Sox4 motif across conditions

Conditions sorted by the z-value of the Sox4 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr10_83244234_83244393	0.70	Slc41a2	solute carrier family 41, member 2	60062	0.11
chr7_113935146_113935310	0.64	Gm45615	predicted gene 45615	151670	0.04
chr4_35916085_35916245	0.59	Lingo2	leucine rich repeat and Ig domain containing 2	70961	0.13
chr7_24500290_24500448	0.58	Cadm4	cell adhesion molecule 4	408	0.68
chr19_16182027_16182207	0.53	E030024N20Rik	RIKEN cDNA E030024N20 gene	17312	0.19
chr7_66106744_66106923	0.52	Chsy1	chondroitin sulfate synthase 1	2682	0.17
chr2_58771297_58771448	0.52	Upp2	uridine phosphorylase 2	6047	0.22
chr8_13169044_13169201	0.46	Lamp1	lysosomal-associated membrane protein 1	4059	0.12
chr15_74994754_74994914	0.45	Ly6a	lymphocyte antigen 6 complex, locus A	2800	0.12
chr5_118571610_118571780	0.44	Gm43785	predicted gene 43785	8594	0.15
chr4_130749359_130749859	0.41	Snord85	small nucleolar RNA, C/D box 85	25	0.96
chr7_132585908_132586066	0.40	Oat	ornithine aminotransferase	9589	0.14
chr9_74892937_74893252	0.39	Onecut1	one cut domain, family member 1	26610	0.14
chr7_26829282_26829437	0.39	Cyp2a5	cytochrome P450, family 2, subfamily a, polypeptide 5	5946	0.17
chr2_32484947_32485331	0.38	Gm37169	predicted gene, 37169	2849	0.15
chr14_73161911_73162182	0.38	Rcbtb2	regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2	106	0.96
chr3_98047351_98047638	0.38	Gm42819	predicted gene 42819	16807	0.17
chr18_38962486_38962657	0.37	Gm5820	predicted gene 5820	6862	0.19
chr2_15610043_15610194	0.37	Gm37595	predicted gene, 37595	79005	0.1
chr19_10067201_10067465	0.35	Fads2	fatty acid desaturase 2	3854	0.16
chr11_16822583_16822870	0.35	Egfros	epidermal growth factor receptor, opposite strand	7976	0.23
chr2_17342233_17342437	0.35	Nebl	nebulette	18751	0.27
chr18_84376797_84376986	0.35	Gm37216	predicted gene, 37216	745	0.73
chr5_125521579_125521730	0.35	Aacs	acetoacetyl-CoA synthetase	6411	0.16
chr18_65520606_65520833	0.35	Gm30018	predicted gene, 30018	11082	0.12
chr16_97792461_97792626	0.34	Prdm15	PR domain containing 15	5376	0.19
chr6_108513973_108514142	0.34	Itpr1	inositol 1,4,5-trisphosphate receptor 1	4675	0.17
chr18_81199291_81199673	0.34	4930594M17Rik	RIKEN cDNA 4930594M17 gene	36584	0.17
chr7_80335806_80335957	0.33	Unc45a	unc-45 myosin chaperone A	3685	0.12
chr2_75960594_75960799	0.30	Ttc30a2	tetratricopeptide repeat domain 30A2	17474	0.14
chr11_98767825_98767976	0.29	Nr1d1	nuclear receptor subfamily 1, group D, member 1	2526	0.15
chr4_54733562_54733749	0.29	Gm12477	predicted gene 12477	63463	0.11
chr9_96437861_96438072	0.28	BC043934	cDNA sequence BC043934	172	0.94
chr6_141662549_141662700	0.28	Slco1b2	solute carrier organic anion transporter family, member 1b2	10369	0.27
chr7_19441871_19442030	0.28	Mark4	MAP/microtubule affinity regulating kinase 4	6666	0.08
chr3_148957664_148957815	0.27	Adgrl2	adhesion G protein-coupled receptor L2	2952	0.29
chr7_15981709_15981860	0.27	Bicra	BRD4 interacting chromatin remodeling complex associated protein	3059	0.15
chr19_34828291_34828506	0.27	Mir107	microRNA 107	7625	0.14
chr11_98775849_98776027	0.26	Nr1d1	nuclear receptor subfamily 1, group D, member 1	605	0.56
chr5_147313676_147313887	0.26	Cdx2	caudal type homeobox 2	6511	0.11
chr12_54710441_54710776	0.26	Gm22634	predicted gene, 22634	300	0.72
chr11_16818941_16819203	0.26	Egfros	epidermal growth factor receptor, opposite strand	11630	0.22
chrX_159817258_159817435	0.26	Sh3kbp1	SH3-domain kinase binding protein 1	23122	0.25
chr5_130027278_130027450	0.25	Asl	argininosuccinate lyase	1883	0.2
chr4_130630552_130630730	0.25	Pum1	pumilio RNA-binding family member 1	32680	0.16
chr17_63010946_63011130	0.25	Gm25348	predicted gene, 25348	85962	0.1
chr7_117386572_117386727	0.25	Gm45153	predicted gene 45153	4787	0.26
chr9_13681735_13681905	0.25	Maml2	mastermind like transcriptional coactivator 2	19360	0.18
chr19_56170856_56171017	0.25	Gm31912	predicted gene, 31912	64626	0.11
chr16_20412097_20412250	0.24	Abcc5	ATP-binding cassette, sub-family C (CFTR/MRP), member 5	11887	0.14
chr2_65441659_65441885	0.24	Scn3a	sodium channel, voltage-gated, type III, alpha	53459	0.11
chr8_104095732_104095883	0.24	Cdh5	cadherin 5	5818	0.15
chr1_85093829_85093980	0.23	Gm10553	predicted gene 10553	5608	0.1
chr11_16854764_16854960	0.23	Egfr	epidermal growth factor receptor	23288	0.17
chr19_10094218_10094369	0.23	Fads2	fatty acid desaturase 2	5577	0.16
chr11_16813698_16813849	0.23	Egfros	epidermal growth factor receptor, opposite strand	16929	0.21
chr2_141285965_141286164	0.23	Macrod2os1	mono-ADP ribosylhydrolase 2, opposite strand 1	927	0.69
chr1_164120420_164120571	0.23	Selp	selectin, platelet	5231	0.14
chr7_50105525_50105881	0.23	Nell1	NEL-like 1	7393	0.32
chr1_178528531_178528699	0.23	Kif26b	kinesin family member 26B	510	0.84
chr7_79309461_79309624	0.23	Gm39041	predicted gene, 39041	10517	0.14
chr1_36807833_36808005	0.22	Tmem131	transmembrane protein 131	2617	0.21
chr2_118696590_118696966	0.22	Ankrd63	ankyrin repeat domain 63	7185	0.13
chr7_26301156_26301307	0.22	Cyp2a4	cytochrome P450, family 2, subfamily a, polypeptide 4	5938	0.13
chr17_10511158_10511318	0.22	Gm16168	predicted gene 16168	14785	0.24
chr16_10976433_10976649	0.22	Litaf	LPS-induced TN factor	962	0.41
chr1_165184250_165184426	0.21	Sft2d2	SFT2 domain containing 2	9979	0.14
chr6_141671866_141672017	0.21	Slco1b2	solute carrier organic anion transporter family, member 1b2	9305	0.27
chr14_76805432_76805625	0.21	Gm30246	predicted gene, 30246	24701	0.16
chr7_65467465_65467748	0.21	Gm44792	predicted gene 44792	13615	0.21
chr2_134547439_134547602	0.21	Hao1	hydroxyacid oxidase 1, liver	6787	0.31
chr2_132595669_132595997	0.21	AU019990	expressed sequence AU019990	2362	0.24
chr11_16857621_16857825	0.21	Egfr	epidermal growth factor receptor	20427	0.18
chr1_59481889_59482258	0.21	Fzd7	frizzled class receptor 7	351	0.83
chr2_38531241_38531405	0.21	Gm35808	predicted gene, 35808	4384	0.14
chr7_99848918_99849257	0.21	Spcs2	signal peptidase complex subunit 2 homolog (S. cerevisiae)	9772	0.11
chr2_68874298_68874495	0.21	Cers6	ceramide synthase 6	12810	0.14
chr18_75389536_75389700	0.20	Smad7	SMAD family member 7	14704	0.21
chr17_69982645_69982841	0.20	Dlgap1	DLG associated protein 1	13322	0.24
chr9_98429903_98430078	0.20	Rbp1	retinol binding protein 1, cellular	7029	0.21
chr17_47304154_47304305	0.20	Trerf1	transcriptional regulating factor 1	10160	0.16
chr5_135725445_135725806	0.20	Por	P450 (cytochrome) oxidoreductase	103	0.94
chr7_98002722_98002888	0.20	Gdpd4	glycerophosphodiester phosphodiesterase domain containing 4	44984	0.13
chr10_94469219_94469370	0.20	Tmcc3	transmembrane and coiled coil domains 3	45563	0.14
chr2_42022841_42022992	0.20	Gm13461	predicted gene 13461	34087	0.23
chr19_12718913_12719287	0.20	Gm15962	predicted gene 15962	2103	0.19
chr19_8613413_8613628	0.19	Slc22a6	solute carrier family 22 (organic anion transporter), member 6	4519	0.12
chr1_193928644_193928965	0.19	Gm21362	predicted gene, 21362	61795	0.15
chr4_97765098_97765412	0.19	Nfia	nuclear factor I/A	7479	0.2
chr8_11010925_11011239	0.19	Irs2	insulin receptor substrate 2	2624	0.19
chr4_154506853_154507016	0.19	Prdm16	PR domain containing 16	21831	0.18
chr5_54034513_54034730	0.19	Stim2	stromal interaction molecule 2	36056	0.18
chr9_15537781_15537949	0.19	Smco4	single-pass membrane protein with coiled-coil domains 4	17006	0.16
chr9_74706331_74706505	0.19	Gm27233	predicted gene 27233	2844	0.32
chr1_170924605_170924775	0.19	Gm2962	predicted pseudogene 2962	954	0.33
chr10_80174407_80174582	0.19	Fam174c	family with sequence similarity 174, member C	1550	0.18
chr6_66898216_66898367	0.19	Gng12	guanine nucleotide binding protein (G protein), gamma 12	1400	0.3
chr11_16872747_16873031	0.18	Egfr	epidermal growth factor receptor	5261	0.23
chr14_22589711_22589891	0.18	Lrmda	leucine rich melanocyte differentiation associated	6712	0.24
chr1_165817347_165817510	0.18	Gm23402	predicted gene, 23402	7686	0.1
chr4_49553429_49553778	0.18	Aldob	aldolase B, fructose-bisphosphate	4057	0.17
chr2_158037741_158037902	0.18	Rprd1b	regulation of nuclear pre-mRNA domain containing 1B	5602	0.18
chr11_16784544_16784843	0.18	Egfr	epidermal growth factor receptor	32463	0.16
chr3_79903884_79904035	0.18	Gm36569	predicted gene, 36569	17153	0.17
chr9_6786497_6786659	0.18	Gm48675	predicted gene, 48675	15265	0.26
chr11_70236702_70236853	0.18	0610010K14Rik	RIKEN cDNA 0610010K14 gene	127	0.86
chr3_89139844_89139995	0.18	Pklr	pyruvate kinase liver and red blood cell	3296	0.09
chr3_9610870_9611024	0.18	Zfp704	zinc finger protein 704	862	0.67
chr2_129526434_129526601	0.18	F830045P16Rik	RIKEN cDNA F830045P16 gene	10085	0.16
chr8_46387074_46387264	0.18	Gm45253	predicted gene 45253	1281	0.38
chr6_55170633_55170787	0.18	Inmt	indolethylamine N-methyltransferase	4304	0.19
chr14_66132883_66133034	0.18	Chrna2	cholinergic receptor, nicotinic, alpha polypeptide 2 (neuronal)	2081	0.27
chr14_119816401_119816559	0.18	4930404K13Rik	RIKEN cDNA 4930404K13 gene	17502	0.21
chr6_149344317_149344633	0.18	Gm15782	predicted gene 15782	9351	0.14
chr16_96127404_96127899	0.17	Hmgn1	high mobility group nucleosomal binding domain 1	47	0.96
chr8_72503838_72503991	0.17	Gm17435	predicted gene, 17435	10970	0.08
chr17_6018338_6018665	0.17	Synj2	synaptojanin 2	4952	0.19
chr15_85538329_85538480	0.17	Gm4825	predicted pseudogene 4825	27592	0.13
chr13_73320522_73320699	0.17	Gm10263	predicted gene 10263	2766	0.2
chr11_90356770_90356930	0.17	Hlf	hepatic leukemia factor	25085	0.22
chr3_149239531_149239709	0.17	Gm10287	predicted gene 10287	13875	0.2
chr8_107206262_107206573	0.16	Cyb5b	cytochrome b5 type B	40502	0.12
chr1_134173185_134173337	0.16	Chil1	chitinase-like 1	8915	0.14
chr8_107117129_107117285	0.16	C630050I24Rik	RIKEN cDNA C630050I24 gene	1903	0.22
chr16_17656326_17656735	0.16	Med15	mediator complex subunit 15	677	0.52
chr12_119071015_119071241	0.16	Gm18921	predicted gene, 18921	3698	0.34
chr7_79279429_79279594	0.16	Gm44639	predicted gene 44639	1744	0.27
chr17_87377697_87377853	0.16	Ttc7	tetratricopeptide repeat domain 7	1078	0.43
chr14_60993572_60993791	0.16	Tnfrsf19	tumor necrosis factor receptor superfamily, member 19	17796	0.22
chr12_110499327_110499478	0.16	Gm19605	predicted gene, 19605	13194	0.16
chr9_72260390_72260691	0.16	Gm25163	predicted gene, 25163	3401	0.12
chr9_121435320_121435493	0.16	Trak1	trafficking protein, kinesin binding 1	18890	0.17
chr10_78452749_78452929	0.16	Pdxk	pyridoxal (pyridoxine, vitamin B6) kinase	4593	0.08
chr3_18148711_18148862	0.16	Gm23686	predicted gene, 23686	28839	0.19
chr2_177925591_177925999	0.16	Zfp972	zinc finger protein 972	182	0.93
chr7_69979793_69979981	0.16	Gm24120	predicted gene, 24120	21983	0.21
chr2_117129250_117129573	0.16	Spred1	sprouty protein with EVH-1 domain 1, related sequence	7773	0.22
chr4_108043471_108043786	0.16	Gm23354	predicted gene, 23354	1828	0.25
chr7_112788334_112788697	0.16	Tead1	TEA domain family member 1	28969	0.19
chr19_29470771_29470965	0.16	Pdcd1lg2	programmed cell death 1 ligand 2	48809	0.1
chr19_21829238_21829531	0.16	Gm50130	predicted gene, 50130	4372	0.26
chr15_25677510_25677678	0.16	Myo10	myosin X	3084	0.24
chr14_19986275_19986426	0.16	Gng2	guanine nucleotide binding protein (G protein), gamma 2	8723	0.21
chr17_12658996_12659172	0.15	Slc22a1	solute carrier family 22 (organic cation transporter), member 1	6376	0.19
chr1_39813213_39813385	0.15	Gm3646	predicted gene 3646	7967	0.21
chr11_117234314_117234465	0.15	Septin9	septin 9	2104	0.3
chr3_101804488_101804639	0.15	Mab21l3	mab-21-like 3	31660	0.17
chr17_79020514_79020830	0.15	Prkd3	protein kinase D3	105	0.96
chr7_26880928_26881079	0.15	Cyp2a21-ps	cytochrome P450, family 2, subfamily a, polypeptide 21, pseudogene	36378	0.11
chr7_123405689_123405849	0.15	Lcmt1	leucine carboxyl methyltransferase 1	2411	0.28
chr6_90436303_90436648	0.15	Cfap100	cilia and flagella associated protein 100	7678	0.12
chr8_123702859_123703051	0.15	6030466F02Rik	RIKEN cDNA 6030466F02 gene	31003	0.05
chr13_54632857_54633027	0.15	Faf2	Fas associated factor family member 2	8601	0.12
chr19_40156899_40157166	0.15	Cyp2c70	cytochrome P450, family 2, subfamily c, polypeptide 70	30254	0.13
chr16_32853567_32853731	0.15	Rubcn	RUN domain and cysteine-rich domain containing, Beclin 1-interacting protein	14689	0.12
chr14_60635934_60636102	0.15	Spata13	spermatogenesis associated 13	1263	0.52
chr2_24864822_24864973	0.15	Ehmt1	euchromatic histone methyltransferase 1	974	0.44
chrX_74245766_74245917	0.15	Flna	filamin, alpha	523	0.54
chrX_111648183_111648334	0.15	Hdx	highly divergent homeobox	48821	0.16
chr18_53744559_53744906	0.15	Cep120	centrosomal protein 120	124	0.98
chr1_21267631_21267791	0.15	Gm28836	predicted gene 28836	3882	0.13
chr6_38823949_38824290	0.15	Hipk2	homeodomain interacting protein kinase 2	5773	0.25
chr4_57250984_57251161	0.15	Ptpn3	protein tyrosine phosphatase, non-receptor type 3	29018	0.17
chr11_111602165_111602329	0.15	Gm11676	predicted gene 11676	11059	0.3
chr11_121258796_121258982	0.15	Foxk2	forkhead box K2	1101	0.39
chr17_66708120_66708311	0.15	1700016K05Rik	RIKEN cDNA 1700016K05 gene	6239	0.15
chr17_79883308_79883515	0.15	Atl2	atlastin GTPase 2	12640	0.17
chr11_45533343_45533513	0.15	Gm12162	predicted gene 12162	64924	0.12
chrX_20547825_20547979	0.15	Rgn	regucalcin	1885	0.26
chr13_102698753_102698921	0.14	Cd180	CD180 antigen	5226	0.24
chr4_139186254_139186405	0.14	Gm16287	predicted gene 16287	5674	0.15
chr6_91614903_91615054	0.14	Gm45218	predicted gene 45218	15746	0.13
chr7_141436148_141436439	0.14	Slc25a22	solute carrier family 25 (mitochondrial carrier, glutamate), member 22	896	0.28
chr9_9128366_9128693	0.14	Gm16833	predicted gene, 16833	107759	0.07
chr3_138304273_138304430	0.14	Gm16559	predicted gene 16559	2671	0.17
chr1_74968300_74968461	0.14	Gm37744	predicted gene, 37744	14128	0.12
chr17_46016325_46016519	0.14	Vegfa	vascular endothelial growth factor A	4950	0.19
chr17_29579809_29579984	0.14	Tbc1d22b	TBC1 domain family, member 22B	7473	0.09
chr16_8829001_8829532	0.14	1810013L24Rik	RIKEN cDNA 1810013L24 gene	834	0.6
chr2_91750560_91750711	0.14	Ambra1	autophagy/beclin 1 regulator 1	15810	0.14
chr19_7788761_7788946	0.14	Slc22a26	solute carrier family 22 (organic cation transporter), member 26	13725	0.17
chr6_86670951_86671106	0.14	Mxd1	MAX dimerization protein 1	1867	0.2
chr7_113059372_113059769	0.14	Gm23662	predicted gene, 23662	60128	0.11
chr11_4216611_4216764	0.14	Castor1	cytosolic arginine sensor for mTORC1 subunit 1	1538	0.22
chr9_68906459_68906626	0.14	Rora	RAR-related orphan receptor alpha	251239	0.02
chr2_144256463_144256614	0.14	Snx5	sorting nexin 5	1135	0.31
chr17_80728516_80728734	0.14	Map4k3	mitogen-activated protein kinase kinase kinase kinase 3	140	0.84
chr5_97876322_97876543	0.14	Antxr2	anthrax toxin receptor 2	119663	0.05
chr17_46160193_46160368	0.14	Gtpbp2	GTP binding protein 2	752	0.48
chr13_21778741_21779257	0.14	H1f5	H1.5 linker histone, cluster member	1626	0.11
chrX_74837196_74837401	0.14	Gm5936	predicted gene 5936	102	0.92
chr11_16806184_16806397	0.14	Egfros	epidermal growth factor receptor, opposite strand	24412	0.18
chr19_43803990_43804141	0.14	Abcc2	ATP-binding cassette, sub-family C (CFTR/MRP), member 2	6079	0.16
chr4_151045208_151045385	0.14	Per3	period circadian clock 3	631	0.67
chr12_79830687_79831018	0.14	9430078K24Rik	RIKEN cDNA 9430078K24 gene	93881	0.08
chr12_103947018_103947616	0.13	Serpina1e	serine (or cysteine) peptidase inhibitor, clade A, member 1E	9581	0.11
chrX_11273388_11273552	0.13	H2al1a	H2A histone family member L1A	25787	0.09
chr7_115857826_115857977	0.13	Sox6	SRY (sex determining region Y)-box 6	1951	0.46
chr1_87764802_87764962	0.13	Atg16l1	autophagy related 16-like 1 (S. cerevisiae)	2019	0.23
chr2_176830816_176830976	0.13	Gm14408	predicted gene 14408	244	0.91

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of Sox4

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:1903800	positive regulation of production of miRNAs involved in gene silencing by miRNA(GO:1903800)
0.1	0.2	GO:2000384	regulation of ectoderm development(GO:2000383) negative regulation of ectoderm development(GO:2000384)
0.1	0.2	GO:0003419	growth plate cartilage chondrocyte proliferation(GO:0003419)
0.1	0.2	GO:0072092	ureteric bud invasion(GO:0072092)
0.1	0.2	GO:0000720	pyrimidine dimer repair by nucleotide-excision repair(GO:0000720)
0.0	0.3	GO:0070857	regulation of bile acid biosynthetic process(GO:0070857)
0.0	0.1	GO:0070640	vitamin D3 metabolic process(GO:0070640)
0.0	0.1	GO:1901078	negative regulation of relaxation of muscle(GO:1901078)
0.0	0.1	GO:0061625	fructose catabolic process(GO:0006001) fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate(GO:0061624) glycolytic process through fructose-1-phosphate(GO:0061625)
0.0	0.1	GO:2000598	regulation of cyclin catabolic process(GO:2000598) negative regulation of cyclin catabolic process(GO:2000599)
0.0	0.1	GO:0034214	protein hexamerization(GO:0034214)
0.0	0.1	GO:0035887	aortic smooth muscle cell differentiation(GO:0035887)
0.0	0.1	GO:0038026	reelin-mediated signaling pathway(GO:0038026)
0.0	0.1	GO:0036112	medium-chain fatty-acyl-CoA metabolic process(GO:0036112)
0.0	0.1	GO:0042699	follicle-stimulating hormone signaling pathway(GO:0042699)
0.0	0.1	GO:0010825	positive regulation of centrosome duplication(GO:0010825)
0.0	0.1	GO:0015817	histidine transport(GO:0015817)
0.0	0.1	GO:0008626	granzyme-mediated apoptotic signaling pathway(GO:0008626)
0.0	0.1	GO:0038086	VEGF-activated platelet-derived growth factor receptor signaling pathway(GO:0038086) positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway(GO:0038091)
0.0	0.1	GO:0002314	germinal center B cell differentiation(GO:0002314)
0.0	0.1	GO:2001013	epithelial cell proliferation involved in renal tubule morphogenesis(GO:2001013)
0.0	0.1	GO:0038165	oncostatin-M-mediated signaling pathway(GO:0038165)
0.0	0.1	GO:0034310	primary alcohol catabolic process(GO:0034310)
0.0	0.1	GO:0071276	cellular response to cadmium ion(GO:0071276)
0.0	0.1	GO:0006578	amino-acid betaine biosynthetic process(GO:0006578)
0.0	0.1	GO:0016479	negative regulation of transcription from RNA polymerase I promoter(GO:0016479)
0.0	0.1	GO:0006686	sphingomyelin biosynthetic process(GO:0006686)
0.0	0.1	GO:1903300	negative regulation of glucokinase activity(GO:0033132) negative regulation of hexokinase activity(GO:1903300)
0.0	0.1	GO:0070949	regulation of neutrophil mediated cytotoxicity(GO:0070948) regulation of neutrophil mediated killing of symbiont cell(GO:0070949)
0.0	0.1	GO:0098902	regulation of membrane depolarization during action potential(GO:0098902)
0.0	0.2	GO:0006857	oligopeptide transport(GO:0006857)
0.0	0.1	GO:0010748	negative regulation of plasma membrane long-chain fatty acid transport(GO:0010748)
0.0	0.1	GO:1901509	regulation of endothelial tube morphogenesis(GO:1901509)
0.0	0.1	GO:0032763	regulation of mast cell cytokine production(GO:0032763)
0.0	0.1	GO:0030950	establishment or maintenance of actin cytoskeleton polarity(GO:0030950)
0.0	0.0	GO:0009730	detection of carbohydrate stimulus(GO:0009730) detection of hexose stimulus(GO:0009732) detection of monosaccharide stimulus(GO:0034287) detection of glucose(GO:0051594)
0.0	0.1	GO:0000255	allantoin metabolic process(GO:0000255)
0.0	0.1	GO:0032377	regulation of intracellular lipid transport(GO:0032377) regulation of intracellular sterol transport(GO:0032380) regulation of intracellular cholesterol transport(GO:0032383)
0.0	0.1	GO:0006481	C-terminal protein methylation(GO:0006481)
0.0	0.1	GO:0050882	voluntary musculoskeletal movement(GO:0050882)
0.0	0.1	GO:1903334	positive regulation of protein folding(GO:1903334)
0.0	0.0	GO:0072338	creatinine metabolic process(GO:0046449) cellular lactam metabolic process(GO:0072338)
0.0	0.0	GO:0015889	cobalamin transport(GO:0015889)
0.0	0.0	GO:0046103	inosine biosynthetic process(GO:0046103)
0.0	0.0	GO:1900738	positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathway(GO:1900738)
0.0	0.1	GO:1903966	monounsaturated fatty acid metabolic process(GO:1903964) monounsaturated fatty acid biosynthetic process(GO:1903966)
0.0	0.1	GO:0034773	histone H4-K20 trimethylation(GO:0034773)
0.0	0.0	GO:0008050	female courtship behavior(GO:0008050)
0.0	0.0	GO:0097384	ether lipid biosynthetic process(GO:0008611) glycerol ether biosynthetic process(GO:0046504) cellular lipid biosynthetic process(GO:0097384) ether biosynthetic process(GO:1901503)
0.0	0.0	GO:1990705	cholangiocyte proliferation(GO:1990705)
0.0	0.2	GO:0046855	inositol phosphate dephosphorylation(GO:0046855)
0.0	0.1	GO:0051342	regulation of cyclic-nucleotide phosphodiesterase activity(GO:0051342)
0.0	0.1	GO:0010572	positive regulation of platelet activation(GO:0010572)
0.0	0.0	GO:0006046	N-acetylglucosamine catabolic process(GO:0006046)
0.0	0.1	GO:0060480	lung goblet cell differentiation(GO:0060480)
0.0	0.1	GO:0021780	oligodendrocyte cell fate specification(GO:0021778) oligodendrocyte cell fate commitment(GO:0021779) glial cell fate specification(GO:0021780)
0.0	0.1	GO:0035754	B cell chemotaxis(GO:0035754)
0.0	0.1	GO:0071294	cellular response to zinc ion(GO:0071294)
0.0	0.1	GO:0044034	negative stranded viral RNA replication(GO:0039689) multi-organism biosynthetic process(GO:0044034)
0.0	0.0	GO:0070966	nuclear-transcribed mRNA catabolic process, no-go decay(GO:0070966)
0.0	0.0	GO:0036438	maintenance of lens transparency(GO:0036438)
0.0	0.0	GO:0051388	positive regulation of neurotrophin TRK receptor signaling pathway(GO:0051388)
0.0	0.0	GO:0007354	zygotic determination of anterior/posterior axis, embryo(GO:0007354)
0.0	0.0	GO:1902263	apoptotic process involved in embryonic digit morphogenesis(GO:1902263)
0.0	0.0	GO:0051919	positive regulation of fibrinolysis(GO:0051919)
0.0	0.0	GO:0060482	lobar bronchus development(GO:0060482)
0.0	0.0	GO:0019676	ammonia assimilation cycle(GO:0019676)
0.0	0.2	GO:0032012	ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.0	0.0	GO:0015014	heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0015014)
0.0	0.0	GO:0050904	diapedesis(GO:0050904)
0.0	0.0	GO:0046684	response to pyrethroid(GO:0046684)
0.0	0.1	GO:0000185	activation of MAPKKK activity(GO:0000185)
0.0	0.0	GO:0060023	soft palate development(GO:0060023)
0.0	0.0	GO:1901475	pyruvate transmembrane transport(GO:1901475)
0.0	0.1	GO:0030206	chondroitin sulfate biosynthetic process(GO:0030206)
0.0	0.1	GO:0071257	cellular response to electrical stimulus(GO:0071257)
0.0	0.0	GO:2000646	positive regulation of receptor catabolic process(GO:2000646)
0.0	0.0	GO:1904694	negative regulation of vascular smooth muscle contraction(GO:1904694)
0.0	0.1	GO:0060394	negative regulation of pathway-restricted SMAD protein phosphorylation(GO:0060394)
0.0	0.1	GO:2001224	positive regulation of neuron migration(GO:2001224)
0.0	0.0	GO:0032789	saturated monocarboxylic acid metabolic process(GO:0032788) unsaturated monocarboxylic acid metabolic process(GO:0032789)
0.0	0.0	GO:0010248	establishment or maintenance of transmembrane electrochemical gradient(GO:0010248)
0.0	0.0	GO:0021564	vagus nerve development(GO:0021564)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:0097487	multivesicular body, internal vesicle(GO:0097487)
0.0	0.2	GO:0031315	extrinsic component of mitochondrial outer membrane(GO:0031315)
0.0	0.1	GO:0045098	type III intermediate filament(GO:0045098)
0.0	0.1	GO:0031523	Myb complex(GO:0031523)
0.0	0.1	GO:0032127	dense core granule membrane(GO:0032127)
0.0	0.2	GO:0016589	NURF complex(GO:0016589)
0.0	0.1	GO:0032010	phagolysosome(GO:0032010)
0.0	0.1	GO:0000138	Golgi trans cisterna(GO:0000138)
0.0	0.0	GO:0031088	platelet dense granule membrane(GO:0031088)
0.0	0.1	GO:0097425	smooth endoplasmic reticulum membrane(GO:0030868) smooth endoplasmic reticulum part(GO:0097425)
0.0	0.2	GO:0071564	npBAF complex(GO:0071564)
0.0	0.0	GO:0031092	platelet alpha granule membrane(GO:0031092)
0.0	0.1	GO:0031931	TORC1 complex(GO:0031931)
0.0	0.1	GO:0031298	replication fork protection complex(GO:0031298)
0.0	0.0	GO:0005945	6-phosphofructokinase complex(GO:0005945)
0.0	0.0	GO:0002142	stereocilia ankle link complex(GO:0002142)
0.0	0.0	GO:0048179	activin receptor complex(GO:0048179)
0.0	0.0	GO:0043293	apoptosome(GO:0043293)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:0048408	epidermal growth factor binding(GO:0048408)
0.1	0.2	GO:0031826	type 2A serotonin receptor binding(GO:0031826)
0.0	0.2	GO:0003958	NADPH-hemoprotein reductase activity(GO:0003958)
0.0	0.0	GO:0016509	long-chain-3-hydroxyacyl-CoA dehydrogenase activity(GO:0016509)
0.0	0.1	GO:0050510	N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity(GO:0050510)
0.0	0.1	GO:0015252	hydrogen ion channel activity(GO:0015252)
0.0	0.1	GO:0070061	fructose binding(GO:0070061)
0.0	0.1	GO:0034988	Fc-gamma receptor I complex binding(GO:0034988)
0.0	0.2	GO:0016215	acyl-CoA desaturase activity(GO:0016215)
0.0	0.2	GO:0015198	oligopeptide transporter activity(GO:0015198)
0.0	0.1	GO:0004924	oncostatin-M receptor activity(GO:0004924)
0.0	0.1	GO:0004439	phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity(GO:0004439)
0.0	0.1	GO:0036042	long-chain fatty acyl-CoA binding(GO:0036042)
0.0	0.1	GO:0015182	L-asparagine transmembrane transporter activity(GO:0015182) L-glutamine transmembrane transporter activity(GO:0015186)
0.0	0.1	GO:0001031	RNA polymerase III type 1 promoter DNA binding(GO:0001030) RNA polymerase III type 2 promoter DNA binding(GO:0001031) RNA polymerase III type 3 promoter DNA binding(GO:0001032) 5S rDNA binding(GO:0080084)
0.0	0.1	GO:0046976	histone methyltransferase activity (H3-K27 specific)(GO:0046976)
0.0	0.1	GO:0047760	butyrate-CoA ligase activity(GO:0047760)
0.0	0.1	GO:0016899	oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor(GO:0016899)
0.0	0.1	GO:0030158	protein xylosyltransferase activity(GO:0030158)
0.0	0.1	GO:0070326	very-low-density lipoprotein particle receptor binding(GO:0070326)
0.0	0.1	GO:0050692	DBD domain binding(GO:0050692)
0.0	0.1	GO:0005007	fibroblast growth factor-activated receptor activity(GO:0005007)
0.0	0.1	GO:0004470	malic enzyme activity(GO:0004470) malate dehydrogenase (decarboxylating) (NAD+) activity(GO:0004471)
0.0	0.0	GO:0004711	ribosomal protein S6 kinase activity(GO:0004711)
0.0	0.0	GO:0042392	sphingosine-1-phosphate phosphatase activity(GO:0042392)
0.0	0.0	GO:0004427	inorganic diphosphatase activity(GO:0004427)
0.0	0.2	GO:0001222	transcription corepressor binding(GO:0001222)
0.0	0.0	GO:0043125	ErbB-3 class receptor binding(GO:0043125)
0.0	0.0	GO:0016842	amidine-lyase activity(GO:0016842)
0.0	0.2	GO:0008574	ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.0	0.0	GO:0016508	long-chain-enoyl-CoA hydratase activity(GO:0016508)
0.0	0.0	GO:0043423	3-phosphoinositide-dependent protein kinase binding(GO:0043423)
0.0	0.1	GO:0005329	dopamine transmembrane transporter activity(GO:0005329)
0.0	0.1	GO:0005025	transforming growth factor beta receptor activity, type I(GO:0005025)
0.0	0.0	GO:0003986	acetyl-CoA hydrolase activity(GO:0003986)
0.0	0.0	GO:0005220	inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.0	0.0	GO:0030620	U2 snRNA binding(GO:0030620)
0.0	0.1	GO:0070053	thrombospondin receptor activity(GO:0070053)
0.0	0.1	GO:0043184	vascular endothelial growth factor receptor 2 binding(GO:0043184)
0.0	0.1	GO:0005072	transforming growth factor beta receptor, cytoplasmic mediator activity(GO:0005072)
0.0	0.1	GO:0097642	calcitonin family receptor activity(GO:0097642)
0.0	0.0	GO:0016882	cyclo-ligase activity(GO:0016882)
0.0	0.2	GO:0031492	nucleosomal DNA binding(GO:0031492)
0.0	0.0	GO:0050833	pyruvate transmembrane transporter activity(GO:0050833)
0.0	0.0	GO:2001070	starch binding(GO:2001070)
0.0	0.1	GO:0008349	MAP kinase kinase kinase kinase activity(GO:0008349)
0.0	0.0	GO:0055056	D-glucose transmembrane transporter activity(GO:0055056)
0.0	0.1	GO:0044213	intronic transcription regulatory region DNA binding(GO:0044213)
0.0	0.0	GO:0033829	O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.4	PID ERBB NETWORK PATHWAY	ErbB receptor signaling network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Total log-likelihood	Term	Description
0.4	REACTOME SHC1 EVENTS IN EGFR SIGNALING	Genes involved in SHC1 events in EGFR signaling
0.0	REACTOME SOS MEDIATED SIGNALLING	Genes involved in SOS-mediated signalling
0.2	REACTOME ALPHA LINOLENIC ACID ALA METABOLISM	Genes involved in alpha-linolenic acid (ALA) metabolism
0.1	REACTOME SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1	Genes involved in Signaling by activated point mutants of FGFR1
0.1	REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT	Genes involved in Organic cation/anion/zwitterion transport
0.0	REACTOME G BETA GAMMA SIGNALLING THROUGH PLC BETA	Genes involved in G beta:gamma signalling through PLC beta