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ENCSR904DTN: DNase-seq of mouse liver in constant darkness

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for Sox7

Z-value: 1.43

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Transcription factors associated with Sox7

Gene Symbol	Gene ID	Gene Info
Sox7 Ensembl NCBI MGI UniProt	ENSMUSG00000063060.5	Sox7

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

Gene	Promoter	Distance	Association probability	Pearson corr. coef.	P-value	Plot
Sox7	chr14_63942319_63942611	1208	0.456001	0.85	3.2e-02	Click!
Sox7	chr14_63957868_63958033	14277	0.157822	-0.81	5.3e-02	Click!
Sox7	chr14_63941003_63941175	2584	0.258372	-0.78	6.7e-02	Click!
Sox7	chr14_63943165_63943771	205	0.936046	-0.74	9.0e-02	Click!
Sox7	chr14_63941556_63941788	2001	0.305936	0.71	1.1e-01	Click!

Activity of the Sox7 motif across conditions

Conditions sorted by the z-value of the Sox7 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr1_127899545_127899941	1.63	Rab3gap1	RAB3 GTPase activating protein subunit 1	1170	0.47
chr7_114735164_114735333	1.15	Insc	INSC spindle orientation adaptor protein	8446	0.16
chr4_22498530_22498747	1.03	Gm30731	predicted gene, 30731	8090	0.16
chr9_45204142_45204293	0.92	Tmprss4	transmembrane protease, serine 4	125	0.93
chr4_44920931_44921086	0.91	Zcchc7	zinc finger, CCHC domain containing 7	2110	0.25
chr1_67211421_67211668	0.90	Gm15668	predicted gene 15668	37656	0.16
chr5_32243149_32243309	0.85	Plb1	phospholipase B1	4122	0.22
chr14_21102558_21102733	0.83	Adk	adenosine kinase	26493	0.19
chr10_87884302_87884648	0.82	Igf1os	insulin-like growth factor 1, opposite strand	21094	0.18
chr2_70813245_70813396	0.81	Tlk1	tousled-like kinase 1	11908	0.21
chr8_104789386_104789560	0.79	Gm45782	predicted gene 45782	3645	0.12
chr1_130734318_130734676	0.77	AA986860	expressed sequence AA986860	2387	0.14
chr1_67160278_67160544	0.75	Cps1	carbamoyl-phosphate synthetase 1	37385	0.17
chr8_93183400_93183567	0.72	Gm45909	predicted gene 45909	7875	0.13
chr7_113961934_113962117	0.70	Gm45615	predicted gene 45615	124873	0.05
chr2_134947281_134947437	0.69	Gm14036	predicted gene 14036	143410	0.04
chr4_63360320_63360510	0.68	Orm2	orosomucoid 2	2034	0.19
chr13_96592864_96593019	0.68	Gm48139	predicted gene, 48139	12736	0.12
chr4_47366562_47366857	0.67	Tgfbr1	transforming growth factor, beta receptor I	13099	0.22
chr6_27782346_27782517	0.67	Gm26310	predicted gene, 26310	114344	0.07
chr10_87913707_87914126	0.67	Igf1os	insulin-like growth factor 1, opposite strand	50535	0.11
chr15_94674453_94674604	0.66	Gm25546	predicted gene, 25546	6858	0.25
chr12_104342354_104343298	0.66	Serpina3k	serine (or cysteine) peptidase inhibitor, clade A, member 3K	4340	0.13
chr2_118307958_118308132	0.65	1700054M17Rik	RIKEN cDNA 1700054M17 gene	3131	0.19
chr15_3482890_3483092	0.63	Ghr	growth hormone receptor	11347	0.28
chr4_107313475_107313626	0.63	Yipf1	Yip1 domain family, member 1	813	0.49
chr9_66699874_66700052	0.63	Car12	carbonic anhydrase 12	13723	0.2
chr18_33436230_33436484	0.63	Nrep	neuronal regeneration related protein	27078	0.18
chr6_23387093_23387244	0.62	Cadps2	Ca2+-dependent activator protein for secretion 2	31249	0.21
chr8_22860131_22860751	0.62	Kat6a	K(lysine) acetyltransferase 6A	892	0.52
chr2_155062362_155062698	0.61	Gm45609	predicted gene 45609	11651	0.13
chr8_25750286_25750467	0.60	Ddhd2	DDHD domain containing 2	526	0.61
chr8_42311444_42311600	0.60	Gm6180	predicted pseudogene 6180	64611	0.15
chr15_54578033_54578470	0.59	Mal2	mal, T cell differentiation protein 2	7059	0.27
chr9_45958350_45958531	0.59	Sidt2	SID1 transmembrane family, member 2	3182	0.13
chr6_13676526_13676747	0.59	Bmt2	base methyltransferase of 25S rRNA 2	1302	0.55
chr19_39346810_39347020	0.59	Cyp2c72-ps	cytochrome P450, family 2, subfamily c, polypeptide 72, pseudogene	452	0.87
chr11_106468981_106469217	0.59	Ern1	endoplasmic reticulum (ER) to nucleus signalling 1	18697	0.14
chr8_26350253_26350419	0.58	Gm31784	predicted gene, 31784	38002	0.12
chr16_43535731_43535882	0.57	Zbtb20	zinc finger and BTB domain containing 20	25498	0.2
chr5_20858526_20858689	0.57	Phtf2	putative homeodomain transcription factor 2	3416	0.23
chr3_105737986_105738138	0.56	Gm43328	predicted gene 43328	4185	0.13
chr3_62340540_62340713	0.56	9330121J05Rik	RIKEN cDNA 9330121J05 gene	94	0.7
chr11_29130922_29131328	0.56	Pnpt1	polyribonucleotide nucleotidyltransferase 1	377	0.88
chr17_84742495_84742888	0.56	Lrpprc	leucine-rich PPR-motif containing	8571	0.17
chr6_52009095_52009246	0.55	Skap2	src family associated phosphoprotein 2	3345	0.2
chr11_16867245_16867846	0.55	Egfr	epidermal growth factor receptor	10605	0.2
chr4_117131790_117132241	0.55	Plk3	polo like kinase 3	1784	0.13
chr5_130015627_130015778	0.55	Asl	argininosuccinate lyase	980	0.41
chr13_91748092_91748287	0.54	Gm27656	predicted gene, 27656	3917	0.17
chr5_91039831_91039982	0.54	Epgn	epithelial mitogen	12442	0.17
chr6_117360291_117360442	0.53	Gm4640	predicted gene 4640	63251	0.12
chr8_127515465_127515616	0.53	Gm6921	predicted pseudogene 6921	45895	0.17
chr7_63899068_63899509	0.51	Gm27252	predicted gene 27252	1314	0.37
chr4_40145230_40145427	0.51	Aco1	aconitase 1	2247	0.3
chr6_149150480_149150842	0.51	Etfbkmt	electron transfer flavoprotein beta subunit lysine methyltransferase	9015	0.13
chr15_82433343_82433494	0.50	Cyp2d9	cytochrome P450, family 2, subfamily d, polypeptide 9	19	0.57
chr9_119309703_119309944	0.50	Gm22729	predicted gene, 22729	3066	0.17
chr2_146311135_146311471	0.50	Gm14117	predicted gene 14117	5756	0.24
chr1_63122681_63122832	0.49	Gm20342	predicted gene, 20342	5638	0.1
chr8_95751194_95751345	0.49	Mir7073	microRNA 7073	1945	0.17
chr3_82036127_82036278	0.49	Gucy1b1	guanylate cyclase 1, soluble, beta 1	880	0.6
chr1_119648022_119648226	0.48	Epb41l5	erythrocyte membrane protein band 4.1 like 5	493	0.78
chr4_102583510_102583771	0.48	Pde4b	phosphodiesterase 4B, cAMP specific	3918	0.35
chr4_71811423_71811574	0.48	Gm11232	predicted gene 11232	53533	0.15
chr2_122158672_122158840	0.48	Trim69	tripartite motif-containing 69	1944	0.21
chr4_12481585_12481744	0.48	Gm37985	predicted gene, 37985	115724	0.06
chr4_9665988_9666139	0.48	Asph	aspartate-beta-hydroxylase	3023	0.24
chr9_32870948_32871133	0.47	Gm37167	predicted gene, 37167	31118	0.16
chr9_62357318_62357469	0.47	Anp32a	acidic (leucine-rich) nuclear phosphoprotein 32 family, member A	9545	0.21
chr2_31511401_31511572	0.47	Ass1	argininosuccinate synthetase 1	7004	0.18
chr16_35491110_35491284	0.47	Pdia5	protein disulfide isomerase associated 5	324	0.87
chr4_15066667_15066833	0.47	Gm11844	predicted gene 11844	44168	0.16
chr16_42998828_42999221	0.46	Ndufs5-ps	NADH:ubiquinone oxidoreductase core subunit S5, pseudogene	43393	0.16
chr5_122494527_122494678	0.46	Gm43360	predicted gene 43360	306	0.77
chr6_31551331_31551519	0.46	Podxl	podocalyxin-like	12556	0.18
chr14_59205202_59205353	0.46	Rcbtb1	regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1	336	0.88
chr13_81212164_81212315	0.46	Gm48566	predicted gene, 48566	28545	0.2
chr7_110816193_110816374	0.45	Rnf141	ring finger protein 141	5000	0.16
chr15_5106677_5106828	0.45	Card6	caspase recruitment domain family, member 6	1732	0.22
chr4_108095142_108095451	0.44	Podn	podocan	1149	0.41
chr16_76371516_76371667	0.44	Nrip1	nuclear receptor interacting protein 1	1446	0.43
chr2_34775525_34776380	0.43	Hspa5	heat shock protein 5	1105	0.4
chr1_100410526_100410677	0.43	Gm29667	predicted gene 29667	127810	0.05
chr17_30042343_30042527	0.42	Zfand3	zinc finger, AN1-type domain 3	17947	0.15
chr4_41331357_41331705	0.41	Gm26084	predicted gene, 26084	14420	0.1
chr1_65170171_65170540	0.41	Idh1	isocitrate dehydrogenase 1 (NADP+), soluble	5209	0.15
chr5_122494845_122494996	0.41	Gm43360	predicted gene 43360	12	0.94
chr10_63038751_63038902	0.39	Pbld2	phenazine biosynthesis-like protein domain containing 2	14314	0.09
chr16_46853625_46853776	0.39	Gm6912	predicted gene 6912	220498	0.02
chr2_11427432_11427583	0.39	Gm13296	predicted gene 13296	7283	0.12
chr3_133740354_133740509	0.39	Gm6135	prediticted gene 6135	51073	0.13
chr11_32681512_32681693	0.39	Fbxw11	F-box and WD-40 domain protein 11	38698	0.16
chr11_106429328_106429479	0.39	Icam2	intercellular adhesion molecule 2	41328	0.1
chr6_115653735_115653886	0.39	Gm14335	predicted gene 14335	14751	0.11
chr6_67268636_67268787	0.38	Serbp1	serpine1 mRNA binding protein 1	1381	0.34
chr4_48272957_48273115	0.38	Erp44	endoplasmic reticulum protein 44	6416	0.2
chr19_43808546_43808716	0.38	Abcc2	ATP-binding cassette, sub-family C (CFTR/MRP), member 2	1891	0.28
chr3_52006994_52007318	0.37	Gm37465	predicted gene, 37465	3131	0.17
chr18_20554666_20554835	0.37	Dsg2	desmoglein 2	3324	0.21
chr1_164435834_164435997	0.37	Atp1b1	ATPase, Na+/K+ transporting, beta 1 polypeptide	7804	0.15
chr1_127787315_127787490	0.37	Ccnt2	cyclin T2	9169	0.16
chr3_24123037_24123188	0.37	Naaladl2	N-acetylated alpha-linked acidic dipeptidase-like 2	150927	0.05
chr3_36480639_36480833	0.37	1810062G17Rik	RIKEN cDNA 1810062G17 gene	4799	0.13
chr8_105090981_105091315	0.36	Ces3b	carboxylesterase 3B	2529	0.16
chr3_135442828_135442979	0.36	Ube2d3	ubiquitin-conjugating enzyme E2D 3	3692	0.12
chr9_76727753_76728144	0.36	Gm22938	predicted gene, 22938	11201	0.17
chr3_84234361_84234584	0.36	Trim2	tripartite motif-containing 2	13583	0.23
chr6_17478662_17478867	0.35	Met	met proto-oncogene	12477	0.21
chr2_148031539_148031764	0.35	9030622O22Rik	RIKEN cDNA 9030622O22 gene	6619	0.18
chr9_92257106_92257271	0.35	Plscr1	phospholipid scramblase 1	6846	0.15
chr13_9495114_9495298	0.35	Gm48871	predicted gene, 48871	49306	0.11
chr13_4061646_4061992	0.35	Akr1c14	aldo-keto reductase family 1, member C14	2228	0.22
chr1_51856674_51857057	0.35	Myo1b	myosin IB	5759	0.17
chr6_29852245_29852396	0.35	Ahcyl2	S-adenosylhomocysteine hydrolase-like 2	1440	0.41
chr17_78379527_78379767	0.35	Fez2	fasciculation and elongation protein zeta 2 (zygin II)	21783	0.15
chr1_67127092_67127716	0.34	Cps1	carbamoyl-phosphate synthetase 1	4378	0.28
chr5_146293255_146293729	0.34	Cdk8	cyclin-dependent kinase 8	1418	0.38
chr10_5408928_5409079	0.34	Syne1	spectrin repeat containing, nuclear envelope 1	40517	0.18
chr12_8694008_8694159	0.34	Pum2	pumilio RNA-binding family member 2	4013	0.27
chr11_115219587_115219763	0.34	Nat9	N-acetyltransferase 9 (GCN5-related, putative)	31816	0.08
chr16_84837970_84838147	0.34	Atp5j	ATP synthase, H+ transporting, mitochondrial F0 complex, subunit F	2433	0.2
chr8_125493583_125493749	0.34	Sipa1l2	signal-induced proliferation-associated 1 like 2	956	0.69
chr11_60248805_60248956	0.34	Tom1l2	target of myb1-like 2 (chicken)	3211	0.16
chr19_40141682_40141833	0.33	Cyp2c70	cytochrome P450, family 2, subfamily c, polypeptide 70	45529	0.11
chr7_115680029_115680180	0.33	Sox6	SRY (sex determining region Y)-box 6	17739	0.29
chr3_130339266_130339443	0.33	Gm22682	predicted gene, 22682	133889	0.04
chr14_11158870_11159044	0.33	Slc25a5-ps	Slc25a5 retrotransposed pseudogene	2572	0.28
chr13_4028561_4028716	0.33	Gm47853	predicted gene, 47853	5469	0.14
chr12_79435773_79435986	0.32	Rad51b	RAD51 paralog B	108526	0.06
chr4_134917124_134917439	0.32	Tmem50a	transmembrane protein 50A	2257	0.24
chr12_80124026_80124199	0.32	2310015A10Rik	RIKEN cDNA 2310015A10 gene	2973	0.17
chr15_3453354_3453796	0.32	Ghr	growth hormone receptor	18069	0.26
chr10_17946556_17946707	0.32	Heca	hdc homolog, cell cycle regulator	1436	0.47
chr16_11176623_11176798	0.32	Zc3h7a	zinc finger CCCH type containing 7 A	317	0.74
chr15_97025258_97025453	0.32	Slc38a4	solute carrier family 38, member 4	5033	0.31
chr6_35338820_35339318	0.32	1700065J11Rik	RIKEN cDNA 1700065J11 gene	8223	0.18
chr2_43592187_43592360	0.32	Kynu	kynureninase	7342	0.3
chr9_46481072_46481223	0.31	Gm47144	predicted gene, 47144	23926	0.16
chr1_71595444_71595633	0.31	Fn1	fibronectin 1	4467	0.23
chr11_18900021_18900190	0.31	2900018N21Rik	RIKEN cDNA 2900018N21 gene	10265	0.16
chr4_19970512_19970663	0.31	4930480G23Rik	RIKEN cDNA 4930480G23 gene	27649	0.17
chr5_136258958_136259125	0.31	Sh2b2	SH2B adaptor protein 2	12485	0.13
chr5_17998832_17999006	0.31	Gnat3	guanine nucleotide binding protein, alpha transducing 3	36370	0.22
chr19_44394517_44394772	0.31	Scd1	stearoyl-Coenzyme A desaturase 1	12046	0.14
chr4_108849580_108849741	0.31	Kti12	KTI12 homolog, chromatin associated	1875	0.25
chr7_66075917_66076093	0.30	Gm45081	predicted gene 45081	3468	0.14
chr19_59979470_59979621	0.30	Gm4219	predicted gene 4219	35823	0.15
chr5_23578433_23578591	0.30	Srpk2	serine/arginine-rich protein specific kinase 2	29142	0.15
chr10_69218422_69218684	0.30	Rhobtb1	Rho-related BTB domain containing 1	832	0.61
chr3_95324375_95324754	0.30	Cers2	ceramide synthase 2	3624	0.1
chr8_47712885_47713036	0.30	E030037K01Rik	RIKEN cDNA E030037K01 gene	306	0.75
chr13_96668366_96668901	0.30	Hmgcr	3-hydroxy-3-methylglutaryl-Coenzyme A reductase	1021	0.47
chr7_127277970_127278299	0.30	Sephs2	selenophosphate synthetase 2	4079	0.08
chr6_93770467_93770664	0.30	Magi1	membrane associated guanylate kinase, WW and PDZ domain containing 1	21974	0.21
chr2_59169467_59169618	0.30	Pkp4	plakophilin 4	7615	0.2
chr3_60582048_60582207	0.29	Mbnl1	muscleblind like splicing factor 1	13514	0.2
chr13_119378503_119378661	0.29	Nnt	nicotinamide nucleotide transhydrogenase	30370	0.15
chr2_31515291_31515653	0.28	Ass1	argininosuccinate synthetase 1	3018	0.23
chr9_74790782_74790933	0.28	Gm22315	predicted gene, 22315	8787	0.19
chr1_57386674_57386899	0.28	Tyw5	tRNA-yW synthesizing protein 5	3985	0.16
chr4_92376164_92376339	0.28	Gm12638	predicted gene 12638	2903	0.4
chr10_67191188_67191347	0.28	Jmjd1c	jumonji domain containing 1C	5514	0.23
chr9_65748388_65748657	0.28	Zfp609	zinc finger protein 609	47378	0.11
chr11_16767286_16767565	0.28	Egfr	epidermal growth factor receptor	15195	0.19
chr1_168242978_168243129	0.28	Pbx1	pre B cell leukemia homeobox 1	78391	0.1
chr12_57444721_57445109	0.28	Gm16246	predicted gene 16246	5205	0.25
chr3_97616365_97616788	0.28	Chd1l	chromodomain helicase DNA binding protein 1-like	6373	0.15
chr11_117359987_117360146	0.28	Septin9	septin 9	706	0.68
chr9_120776284_120776475	0.28	Gm47066	predicted gene, 47066	15607	0.11
chr15_6891673_6891824	0.28	Osmr	oncostatin M receptor	16779	0.26
chr16_22241727_22242034	0.28	Gm36796	predicted gene, 36796	2288	0.19
chr7_99201987_99202161	0.28	Gm45012	predicted gene 45012	292	0.86
chr17_64767271_64767462	0.27	Dreh	down-regulated in hepatocellular carcinoma	255	0.93
chr1_135210155_135210339	0.27	Gm4204	predicted gene 4204	21748	0.1
chr3_133833846_133834006	0.27	Gm30484	predicted gene, 30484	15408	0.23
chr17_32348126_32348277	0.27	Akap8l	A kinase (PRKA) anchor protein 8-like	2305	0.19
chr10_87718160_87718329	0.27	Gm48195	predicted gene, 48195	29666	0.21
chr11_16862337_16862489	0.26	Egfr	epidermal growth factor receptor	15737	0.19
chr7_89401915_89402333	0.26	Tmem135	transmembrane protein 135	2098	0.22
chr19_57272214_57272473	0.26	4930449E18Rik	RIKEN cDNA 4930449E18 gene	1617	0.39
chr18_12635155_12635343	0.26	Ttc39c	tetratricopeptide repeat domain 39C	8095	0.15
chr18_64628060_64628409	0.26	Gm6978	predicted gene 6978	15135	0.14
chr6_119390969_119391120	0.26	Adipor2	adiponectin receptor 2	796	0.67
chr15_31230889_31231047	0.26	Dap	death-associated protein	5772	0.19
chr13_52188692_52188881	0.25	Gm48199	predicted gene, 48199	8375	0.27
chr7_35142488_35142656	0.25	Gm35665	predicted gene, 35665	1123	0.34
chr17_13687760_13687927	0.25	Gm16046	predicted gene 16046	4327	0.17
chrX_136321797_136321962	0.25	Nsa2-ps2	NSA2 ribosome biogenesis homolog, pseudogene 2	6420	0.09
chr2_35103269_35103589	0.25	AI182371	expressed sequence AI182371	1886	0.29
chr14_68297607_68297758	0.25	Gm47212	predicted gene, 47212	79429	0.1
chr11_60837742_60838309	0.25	Dhrs7b	dehydrogenase/reductase (SDR family) member 7B	7346	0.1
chr3_105758672_105758857	0.25	Rap1a	RAS-related protein 1a	8436	0.11
chr1_60616128_60616279	0.25	Gm23762	predicted gene, 23762	2400	0.22
chr1_166153672_166153856	0.25	Gpa33	glycoprotein A33 (transmembrane)	23297	0.15
chr12_79599250_79599471	0.25	Rad51b	RAD51 paralog B	272007	0.01
chr6_56795662_56795822	0.25	Kbtbd2	kelch repeat and BTB (POZ) domain containing 2	1005	0.43
chr1_84300039_84300190	0.25	Pid1	phosphotyrosine interaction domain containing 1	15469	0.24
chr13_4205947_4206185	0.25	Akr1c13	aldo-keto reductase family 1, member C13	12208	0.13
chr11_86739271_86739543	0.25	Cltc	clathrin, heavy polypeptide (Hc)	12924	0.18

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of Sox7

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.3	0.8	GO:1903371	regulation of endoplasmic reticulum tubular network organization(GO:1903371)
0.2	0.5	GO:0035928	rRNA import into mitochondrion(GO:0035928)
0.1	0.4	GO:0009826	unidimensional cell growth(GO:0009826)
0.1	0.7	GO:0006526	arginine biosynthetic process(GO:0006526)
0.1	0.3	GO:1903800	positive regulation of production of miRNAs involved in gene silencing by miRNA(GO:1903800)
0.1	0.2	GO:0060741	prostate gland stromal morphogenesis(GO:0060741)
0.1	0.3	GO:0006987	activation of signaling protein activity involved in unfolded protein response(GO:0006987)
0.1	0.2	GO:0001543	ovarian follicle rupture(GO:0001543)
0.1	0.2	GO:0033353	S-adenosylmethionine cycle(GO:0033353)
0.1	0.2	GO:2000152	regulation of ubiquitin-specific protease activity(GO:2000152)
0.1	0.2	GO:0018197	peptidyl-aspartic acid modification(GO:0018197)
0.0	0.1	GO:0060128	corticotropin hormone secreting cell differentiation(GO:0060128)
0.0	0.1	GO:0060178	regulation of exocyst localization(GO:0060178)
0.0	0.2	GO:0010792	DNA double-strand break processing involved in repair via single-strand annealing(GO:0010792)
0.0	0.1	GO:1904479	negative regulation of intestinal absorption(GO:1904479)
0.0	0.1	GO:0019626	short-chain fatty acid catabolic process(GO:0019626)
0.0	0.1	GO:0000432	regulation of transcription from RNA polymerase II promoter by glucose(GO:0000430) positive regulation of transcription from RNA polymerase II promoter by glucose(GO:0000432)
0.0	0.1	GO:0070973	protein localization to endoplasmic reticulum exit site(GO:0070973)
0.0	0.1	GO:0010040	response to iron(II) ion(GO:0010040)
0.0	0.1	GO:0016554	cytidine to uridine editing(GO:0016554)
0.0	0.1	GO:2000741	positive regulation of mesenchymal stem cell differentiation(GO:2000741)
0.0	0.2	GO:0042977	activation of JAK2 kinase activity(GO:0042977)
0.0	0.1	GO:0006166	purine ribonucleoside salvage(GO:0006166)
0.0	0.1	GO:0000957	mitochondrial RNA catabolic process(GO:0000957) regulation of mitochondrial RNA catabolic process(GO:0000960)
0.0	0.3	GO:0090141	positive regulation of mitochondrial fission(GO:0090141)
0.0	0.1	GO:0019086	late viral transcription(GO:0019086)
0.0	0.2	GO:2000344	positive regulation of acrosome reaction(GO:2000344)
0.0	0.1	GO:0019805	quinolinate biosynthetic process(GO:0019805)
0.0	0.2	GO:0045908	negative regulation of vasodilation(GO:0045908)
0.0	0.1	GO:0032474	otolith morphogenesis(GO:0032474)
0.0	0.1	GO:2001274	negative regulation of glucose import in response to insulin stimulus(GO:2001274)
0.0	0.1	GO:1990168	protein K29-linked deubiquitination(GO:0035523) protein K33-linked deubiquitination(GO:1990168)
0.0	0.1	GO:0051081	membrane disassembly(GO:0030397) nuclear envelope disassembly(GO:0051081)
0.0	0.1	GO:1901420	negative regulation of response to alcohol(GO:1901420)
0.0	0.1	GO:0015959	diadenosine polyphosphate metabolic process(GO:0015959)
0.0	0.0	GO:0044314	protein K27-linked ubiquitination(GO:0044314)
0.0	0.2	GO:0061042	vascular wound healing(GO:0061042)
0.0	0.1	GO:0048478	replication fork protection(GO:0048478)
0.0	0.1	GO:0019627	urea metabolic process(GO:0019627)
0.0	0.2	GO:0045602	negative regulation of endothelial cell differentiation(GO:0045602)
0.0	0.2	GO:0001886	endothelial cell morphogenesis(GO:0001886)
0.0	0.1	GO:0006931	substrate-dependent cell migration, cell attachment to substrate(GO:0006931)
0.0	0.1	GO:0034140	negative regulation of toll-like receptor 3 signaling pathway(GO:0034140)
0.0	0.2	GO:0055064	chloride ion homeostasis(GO:0055064)
0.0	0.1	GO:0021869	forebrain ventricular zone progenitor cell division(GO:0021869)
0.0	0.1	GO:0050427	3'-phosphoadenosine 5'-phosphosulfate metabolic process(GO:0050427)
0.0	0.2	GO:0001672	regulation of chromatin assembly or disassembly(GO:0001672)
0.0	0.1	GO:0071233	response to leucine(GO:0043201) cellular response to leucine(GO:0071233)
0.0	0.1	GO:0032534	regulation of microvillus assembly(GO:0032534)
0.0	0.1	GO:0090292	nuclear matrix organization(GO:0043578) nuclear matrix anchoring at nuclear membrane(GO:0090292)
0.0	0.1	GO:1901841	regulation of high voltage-gated calcium channel activity(GO:1901841)
0.0	0.1	GO:0010032	meiotic chromosome condensation(GO:0010032)
0.0	0.1	GO:0016095	polyprenol catabolic process(GO:0016095)
0.0	0.1	GO:0060971	embryonic heart tube left/right pattern formation(GO:0060971)
0.0	0.1	GO:0035627	ceramide transport(GO:0035627)
0.0	0.0	GO:0055005	ventricular cardiac myofibril assembly(GO:0055005)
0.0	0.1	GO:1903288	regulation of potassium ion import(GO:1903286) positive regulation of potassium ion import(GO:1903288)
0.0	0.1	GO:0070782	phosphatidylserine exposure on apoptotic cell surface(GO:0070782)
0.0	0.1	GO:2000686	regulation of rubidium ion transmembrane transporter activity(GO:2000686)
0.0	0.0	GO:0001922	B-1 B cell homeostasis(GO:0001922)
0.0	0.1	GO:0038165	oncostatin-M-mediated signaling pathway(GO:0038165)
0.0	0.1	GO:0001983	baroreceptor response to increased systemic arterial blood pressure(GO:0001983)
0.0	0.1	GO:1903966	monounsaturated fatty acid metabolic process(GO:1903964) monounsaturated fatty acid biosynthetic process(GO:1903966)
0.0	0.1	GO:0003164	His-Purkinje system development(GO:0003164)
0.0	0.1	GO:0090209	negative regulation of triglyceride metabolic process(GO:0090209)
0.0	0.1	GO:0043651	linoleic acid metabolic process(GO:0043651)
0.0	0.0	GO:0015747	urate transport(GO:0015747)
0.0	0.1	GO:0042701	progesterone secretion(GO:0042701)
0.0	0.2	GO:0006977	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest(GO:0006977)
0.0	0.1	GO:0033133	positive regulation of glucokinase activity(GO:0033133)
0.0	0.0	GO:0003431	growth plate cartilage chondrocyte development(GO:0003431)
0.0	0.0	GO:0090210	regulation of establishment of blood-brain barrier(GO:0090210)
0.0	0.1	GO:0045741	positive regulation of epidermal growth factor-activated receptor activity(GO:0045741)
0.0	0.1	GO:0090166	Golgi disassembly(GO:0090166)
0.0	0.1	GO:0050882	voluntary musculoskeletal movement(GO:0050882)
0.0	0.0	GO:0006296	nucleotide-excision repair, DNA incision, 5'-to lesion(GO:0006296)
0.0	0.3	GO:0035162	embryonic hemopoiesis(GO:0035162)
0.0	0.1	GO:0038180	nerve growth factor signaling pathway(GO:0038180)
0.0	0.0	GO:0071883	activation of MAPK activity by adrenergic receptor signaling pathway(GO:0071883)
0.0	0.0	GO:0032264	IMP salvage(GO:0032264)
0.0	0.1	GO:0060696	regulation of phospholipid catabolic process(GO:0060696)
0.0	0.1	GO:1900246	positive regulation of RIG-I signaling pathway(GO:1900246)
0.0	0.1	GO:0033227	dsRNA transport(GO:0033227)
0.0	0.0	GO:0045218	zonula adherens maintenance(GO:0045218)
0.0	0.0	GO:1901674	histone H3-K27 acetylation(GO:0043974) regulation of histone H3-K27 acetylation(GO:1901674)
0.0	0.0	GO:0035519	protein K29-linked ubiquitination(GO:0035519)
0.0	0.1	GO:0046218	tryptophan catabolic process(GO:0006569) tryptophan catabolic process to kynurenine(GO:0019441) indole-containing compound catabolic process(GO:0042436) indolalkylamine catabolic process(GO:0046218)
0.0	0.0	GO:0014012	peripheral nervous system axon regeneration(GO:0014012)
0.0	0.1	GO:0042421	norepinephrine biosynthetic process(GO:0042421)
0.0	0.1	GO:0035336	long-chain fatty-acyl-CoA metabolic process(GO:0035336)
0.0	0.0	GO:0035935	androgen secretion(GO:0035935) regulation of androgen secretion(GO:2000834) positive regulation of androgen secretion(GO:2000836)
0.0	0.0	GO:0006553	lysine metabolic process(GO:0006553)
0.0	0.0	GO:0006059	hexitol metabolic process(GO:0006059)
0.0	0.1	GO:1900364	negative regulation of mRNA polyadenylation(GO:1900364)
0.0	0.1	GO:0009052	pentose-phosphate shunt, non-oxidative branch(GO:0009052)
0.0	0.0	GO:2000338	chemokine (C-X-C motif) ligand 1 production(GO:0072566) regulation of chemokine (C-X-C motif) ligand 1 production(GO:2000338)
0.0	0.0	GO:0006188	IMP biosynthetic process(GO:0006188) 'de novo' IMP biosynthetic process(GO:0006189)
0.0	0.1	GO:0048387	negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.0	0.0	GO:0003062	regulation of heart rate by chemical signal(GO:0003062)
0.0	0.1	GO:0050917	sensory perception of umami taste(GO:0050917)
0.0	0.0	GO:0003099	positive regulation of the force of heart contraction by epinephrine-norepinephrine(GO:0001997) positive regulation of the force of heart contraction by chemical signal(GO:0003099)
0.0	0.1	GO:0090315	negative regulation of protein targeting to membrane(GO:0090315)
0.0	0.0	GO:0030951	establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951)
0.0	0.0	GO:0010887	negative regulation of cholesterol storage(GO:0010887)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.9	GO:0071782	endoplasmic reticulum tubular network(GO:0071782)
0.1	0.3	GO:0097487	multivesicular body, internal vesicle(GO:0097487)
0.1	0.3	GO:0070775	H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776)
0.0	0.2	GO:0035867	alphav-beta3 integrin-IGF-1-IGF1R complex(GO:0035867)
0.0	0.1	GO:1990597	AIP1-IRE1 complex(GO:1990597)
0.0	0.4	GO:0070852	cell body fiber(GO:0070852)
0.0	0.5	GO:0000177	cytoplasmic exosome (RNase complex)(GO:0000177)
0.0	0.1	GO:0005658	alpha DNA polymerase:primase complex(GO:0005658)
0.0	0.1	GO:0097648	G-protein coupled receptor dimeric complex(GO:0038037) G-protein coupled receptor complex(GO:0097648)
0.0	0.1	GO:0097543	ciliary inversin compartment(GO:0097543)
0.0	0.1	GO:0000796	condensin complex(GO:0000796)
0.0	0.1	GO:0031088	platelet dense granule membrane(GO:0031088)
0.0	0.1	GO:1904115	axon cytoplasm(GO:1904115)
0.0	0.2	GO:0098533	ATPase dependent transmembrane transport complex(GO:0098533)
0.0	0.1	GO:0002142	stereocilia ankle link complex(GO:0002142)
0.0	0.0	GO:0000110	nucleotide-excision repair factor 1 complex(GO:0000110)
0.0	0.2	GO:0034663	endoplasmic reticulum chaperone complex(GO:0034663)
0.0	0.1	GO:0000276	mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.0	0.1	GO:0005915	zonula adherens(GO:0005915)
0.0	0.1	GO:0036057	filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.0	0.5	GO:0009295	nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.0	0.1	GO:0005577	fibrinogen complex(GO:0005577)
0.0	0.1	GO:0008024	cyclin/CDK positive transcription elongation factor complex(GO:0008024)
0.0	0.0	GO:0060053	neurofilament cytoskeleton(GO:0060053)
0.0	0.0	GO:0032127	dense core granule membrane(GO:0032127)
0.0	0.2	GO:0030057	desmosome(GO:0030057)
0.0	0.0	GO:0036488	CHOP-C/EBP complex(GO:0036488)
0.0	0.1	GO:0032045	guanyl-nucleotide exchange factor complex(GO:0032045)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.4	GO:0016743	carboxyl- or carbamoyltransferase activity(GO:0016743)
0.1	0.3	GO:0005006	epidermal growth factor-activated receptor activity(GO:0005006)
0.1	0.2	GO:0004013	adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.1	0.2	GO:0016842	amidine-lyase activity(GO:0016842)
0.1	0.2	GO:0045340	mercury ion binding(GO:0045340)
0.1	0.2	GO:0030350	iron-responsive element binding(GO:0030350)
0.1	0.2	GO:0055100	adiponectin binding(GO:0055100)
0.1	0.4	GO:0034046	poly(G) binding(GO:0034046)
0.0	0.2	GO:0005025	transforming growth factor beta receptor activity, type I(GO:0005025)
0.0	0.1	GO:0047023	androsterone dehydrogenase activity(GO:0047023)
0.0	0.1	GO:0005220	inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.0	0.1	GO:0003986	acetyl-CoA hydrolase activity(GO:0003986)
0.0	0.1	GO:0004771	sterol esterase activity(GO:0004771)
0.0	0.1	GO:0071614	linoleic acid epoxygenase activity(GO:0071614)
0.0	0.1	GO:0051032	nucleic acid transmembrane transporter activity(GO:0051032) RNA transmembrane transporter activity(GO:0051033)
0.0	0.6	GO:0016864	protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864)
0.0	0.1	GO:0004965	G-protein coupled GABA receptor activity(GO:0004965)
0.0	0.0	GO:0048408	epidermal growth factor binding(GO:0048408)
0.0	0.8	GO:0017112	Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.0	0.2	GO:0032027	myosin light chain binding(GO:0032027)
0.0	0.1	GO:0003873	6-phosphofructo-2-kinase activity(GO:0003873)
0.0	0.1	GO:0031781	melanocortin receptor binding(GO:0031779) type 3 melanocortin receptor binding(GO:0031781) type 4 melanocortin receptor binding(GO:0031782)
0.0	0.1	GO:0004924	oncostatin-M receptor activity(GO:0004924)
0.0	0.3	GO:0004806	triglyceride lipase activity(GO:0004806)
0.0	0.1	GO:0016151	nickel cation binding(GO:0016151)
0.0	0.1	GO:0017034	Rap guanyl-nucleotide exchange factor activity(GO:0017034)
0.0	0.1	GO:0050252	retinol O-fatty-acyltransferase activity(GO:0050252)
0.0	0.2	GO:0070513	death domain binding(GO:0070513)
0.0	0.8	GO:0005044	scavenger receptor activity(GO:0005044)
0.0	0.1	GO:0001069	regulatory region RNA binding(GO:0001069)
0.0	0.1	GO:0097001	ceramide binding(GO:0097001)
0.0	0.1	GO:0047961	glycine N-acyltransferase activity(GO:0047961)
0.0	0.0	GO:0019153	protein-disulfide reductase (glutathione) activity(GO:0019153)
0.0	0.1	GO:0097322	7SK snRNA binding(GO:0097322)
0.0	0.1	GO:0032896	palmitoyl-CoA 9-desaturase activity(GO:0032896)
0.0	0.0	GO:0016822	hydrolase activity, acting on acid carbon-carbon bonds(GO:0016822) hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances(GO:0016823)
0.0	0.1	GO:0036137	kynurenine-oxoglutarate transaminase activity(GO:0016212) kynurenine aminotransferase activity(GO:0036137)
0.0	0.0	GO:0004800	thyroxine 5'-deiodinase activity(GO:0004800)
0.0	0.2	GO:0070402	NADPH binding(GO:0070402)
0.0	0.1	GO:0004566	beta-glucuronidase activity(GO:0004566)
0.0	0.0	GO:0070644	vitamin D response element binding(GO:0070644)
0.0	0.1	GO:1990380	Lys48-specific deubiquitinase activity(GO:1990380)
0.0	0.2	GO:0005159	insulin-like growth factor receptor binding(GO:0005159)
0.0	0.1	GO:0016443	bidentate ribonuclease III activity(GO:0016443)
0.0	0.2	GO:0015643	toxic substance binding(GO:0015643)
0.0	0.1	GO:0016401	palmitoyl-CoA oxidase activity(GO:0016401)
0.0	0.0	GO:0047623	AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.0	0.2	GO:0051787	misfolded protein binding(GO:0051787)
0.0	0.0	GO:1901612	cardiolipin binding(GO:1901612)
0.0	0.1	GO:0070728	leucine binding(GO:0070728)
0.0	0.0	GO:0015143	urate transmembrane transporter activity(GO:0015143) salt transmembrane transporter activity(GO:1901702)
0.0	0.0	GO:0070053	thrombospondin receptor activity(GO:0070053)
0.0	0.1	GO:0004622	lysophospholipase activity(GO:0004622)
0.0	0.1	GO:0042609	CD4 receptor binding(GO:0042609)
0.0	0.1	GO:0030676	Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0	0.0	GO:0050692	DBD domain binding(GO:0050692)
0.0	0.0	GO:0038181	bile acid receptor activity(GO:0038181)
0.0	0.0	GO:0030620	U2 snRNA binding(GO:0030620)
0.0	0.0	GO:0045504	dynein heavy chain binding(GO:0045504)
0.0	0.2	GO:0004089	carbonate dehydratase activity(GO:0004089)
0.0	0.3	GO:0005154	epidermal growth factor receptor binding(GO:0005154)
0.0	0.2	GO:0005521	lamin binding(GO:0005521)
0.0	0.1	GO:0004176	ATP-dependent peptidase activity(GO:0004176)
0.0	0.1	GO:0050815	phosphoserine binding(GO:0050815)

Gene overrepresentation in curated gene sets: canonical pathways category:

Total log-likelihood	Term	Description
0.3	PID ERBB NETWORK PATHWAY	ErbB receptor signaling network
0.0	PID ANGIOPOIETIN RECEPTOR PATHWAY	Angiopoietin receptor Tie2-mediated signaling
0.0	PID CD40 PATHWAY	CD40/CD40L signaling
0.2	PID INTEGRIN5 PATHWAY	Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.1	PID CXCR4 PATHWAY	CXCR4-mediated signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Total log-likelihood	Term	Description
0.2	REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA	Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.4	REACTOME SHC1 EVENTS IN EGFR SIGNALING	Genes involved in SHC1 events in EGFR signaling
0.2	REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS	Genes involved in Signal regulatory protein (SIRP) family interactions
0.2	REACTOME TRYPTOPHAN CATABOLISM	Genes involved in Tryptophan catabolism
0.0	REACTOME DCC MEDIATED ATTRACTIVE SIGNALING	Genes involved in DCC mediated attractive signaling
0.1	REACTOME ARMS MEDIATED ACTIVATION	Genes involved in ARMS-mediated activation
0.2	REACTOME PURINE SALVAGE	Genes involved in Purine salvage
0.1	REACTOME SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1	Genes involved in Signaling by activated point mutants of FGFR1
0.0	REACTOME ENDOSOMAL VACUOLAR PATHWAY	Genes involved in Endosomal/Vacuolar pathway
0.2	REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS	Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.1	REACTOME REGULATION OF BETA CELL DEVELOPMENT	Genes involved in Regulation of beta-cell development
0.1	REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION	Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)