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ENCSR904DTN: DNase-seq of mouse liver in constant darkness

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for Sp2

Z-value: 1.04

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Transcription factors associated with Sp2

Gene Symbol	Gene ID	Gene Info
Sp2 Ensembl NCBI MGI UniProt	ENSMUSG00000018678.6	Sp2

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

Gene	Promoter	Distance	Association probability	Pearson corr. coef.	P-value	Plot
Sp2	chr11_96967452_96967847	1016	0.330273	-0.86	2.7e-02	Click!
Sp2	chr11_96976103_96976321	1499	0.218452	0.82	4.8e-02	Click!
Sp2	chr11_96963893_96964044	4697	0.100484	-0.69	1.3e-01	Click!
Sp2	chr11_96977958_96978364	450	0.662278	0.63	1.8e-01	Click!
Sp2	chr11_96982500_96982661	379	0.722182	-0.62	1.9e-01	Click!

Activity of the Sp2 motif across conditions

Conditions sorted by the z-value of the Sp2 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr11_98767825_98767976	0.78	Nr1d1	nuclear receptor subfamily 1, group D, member 1	2526	0.15
chr4_136090324_136090475	0.78	Gm13009	predicted gene 13009	15427	0.12
chr11_98767109_98767369	0.77	Nr1d1	nuclear receptor subfamily 1, group D, member 1	3187	0.13
chr3_121982194_121982345	0.57	Arhgap29	Rho GTPase activating protein 29	719	0.68
chr10_75835778_75835936	0.50	Gstt2	glutathione S-transferase, theta 2	976	0.36
chr8_119417830_119417981	0.45	Osgin1	oxidative stress induced growth inhibitor 1	16219	0.14
chr6_145865476_145865643	0.44	Bhlhe41	basic helix-loop-helix family, member e41	1	0.97
chr6_145855716_145856207	0.44	Gm43909	predicted gene, 43909	7336	0.17
chr18_21300208_21300569	0.43	Garem1	GRB2 associated regulator of MAPK1 subtype 1	250	0.91
chr16_45945391_45945574	0.42	Gm15638	predicted gene 15638	124	0.96
chr7_127477990_127478144	0.40	Fbrs	fibrosin	1132	0.21
chr8_122497127_122497278	0.38	Piezo1	piezo-type mechanosensitive ion channel component 1	1002	0.33
chr2_25983198_25983706	0.36	Camsap1	calmodulin regulated spectrin-associated protein 1	170	0.93
chr18_64265864_64266047	0.35	St8sia3	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3	31	0.97
chr8_108710919_108711070	0.34	Zfhx3	zinc finger homeobox 3	3650	0.29
chr9_74875936_74876087	0.33	Onecut1	one cut domain, family member 1	9527	0.15
chr1_74807002_74807292	0.31	Wnt10a	wingless-type MMTV integration site family, member 10A	13784	0.11
chr11_95032963_95033336	0.31	Gm11513	predicted gene 11513	390	0.76
chr5_107260769_107260925	0.31	Gm42900	predicted gene 42900	4343	0.17
chr17_86165279_86165510	0.30	Prkce	protein kinase C, epsilon	2391	0.3
chr11_98953496_98953709	0.30	Rara	retinoic acid receptor, alpha	6810	0.11
chr18_34864196_34864456	0.30	Egr1	early growth response 1	3119	0.18
chr8_72492767_72492930	0.29	Gm17435	predicted gene, 17435	86	0.69
chr5_121836951_121837292	0.29	Sh2b3	SH2B adaptor protein 3	262	0.83
chr11_117875729_117875880	0.28	Tha1	threonine aldolase 1	2323	0.16
chr6_137142914_137143065	0.28	Rerg	RAS-like, estrogen-regulated, growth-inhibitor	2926	0.27
chr12_105008860_105009027	0.28	Syne3	spectrin repeat containing, nuclear envelope family member 3	866	0.44
chr19_57877445_57877626	0.27	Mir5623	microRNA 5623	173632	0.03
chr13_109485029_109485208	0.26	Pde4d	phosphodiesterase 4D, cAMP specific	42935	0.21
chr12_86836691_86837004	0.26	Gm10095	predicted gene 10095	9620	0.19
chr4_149393707_149393902	0.26	Ube4b	ubiquitination factor E4B	5574	0.15
chr16_31452530_31452681	0.25	Bdh1	3-hydroxybutyrate dehydrogenase, type 1	5511	0.15
chr3_41580995_41581174	0.25	Jade1	jade family PHD finger 1	228	0.92
chr6_121064341_121064666	0.25	Gm4651	predicted gene 4651	39	0.97
chr18_34511486_34511736	0.25	n-R5s24	nuclear encoded rRNA 5S 24	1874	0.27
chr9_24774302_24774460	0.24	Tbx20	T-box 20	78	0.97
chr19_7196833_7197251	0.24	Otub1	OTU domain, ubiquitin aldehyde binding 1	3422	0.16
chr7_25249677_25249858	0.24	Erf	Ets2 repressor factor	963	0.32
chr1_9967919_9968070	0.24	Tcf24	transcription factor 24	62	0.9
chr15_102029131_102029282	0.23	Krt18	keratin 18	1026	0.4
chr3_142749520_142749995	0.23	Gm15540	predicted gene 15540	5076	0.14
chr11_62076764_62076946	0.23	Specc1	sperm antigen with calponin homology and coiled-coil domains 1	140	0.96
chr1_34389167_34389350	0.23	Gm5266	predicted gene 5266	21887	0.09
chr8_45631075_45631340	0.23	Sorbs2	sorbin and SH3 domain containing 2	3006	0.26
chr14_45056454_45056605	0.23	Gm21010	predicted gene, 21010	34086	0.09
chr11_89937352_89937519	0.23	Pctp	phosphatidylcholine transfer protein	65459	0.12
chr2_29973635_29973786	0.23	Sptan1	spectrin alpha, non-erythrocytic 1	4670	0.13
chr9_107675603_107675819	0.23	Gnat1	guanine nucleotide binding protein, alpha transducing 1	730	0.43
chr7_45053316_45053568	0.23	Prr12	proline rich 12	561	0.42
chr9_62351261_62351449	0.23	Anp32a	acidic (leucine-rich) nuclear phosphoprotein 32 family, member A	6556	0.21
chr1_175692768_175692950	0.22	Chml	choroideremia-like	42	0.54
chr9_42507207_42507377	0.22	Tbcel	tubulin folding cofactor E-like	517	0.81
chr8_84723608_84723805	0.22	G430095P16Rik	RIKEN cDNA G430095P16 gene	699	0.52
chr2_128817774_128817954	0.22	Tmem87b	transmembrane protein 87B	254	0.9
chr5_88796583_88796899	0.22	Gm42912	predicted gene 42912	2845	0.21
chr11_109611461_109611655	0.22	Wipi1	WD repeat domain, phosphoinositide interacting 1	126	0.95
chr9_121380419_121380796	0.22	Trak1	trafficking protein, kinesin binding 1	2187	0.29
chr8_70539199_70539597	0.22	Ell	elongation factor RNA polymerase II	59	0.94
chr15_101266552_101266884	0.21	Nr4a1	nuclear receptor subfamily 4, group A, member 1	128	0.93
chr9_25455109_25455478	0.21	Gm8049	predicted gene 8049	4831	0.23
chrX_100447058_100447240	0.21	Awat2	acyl-CoA wax alcohol acyltransferase 2	4432	0.18
chr6_113306564_113306942	0.21	Gm43935	predicted gene, 43935	79	0.8
chr11_76911521_76911684	0.21	Tmigd1	transmembrane and immunoglobulin domain containing 1	7040	0.17
chr15_97029364_97029596	0.21	Slc38a4	solute carrier family 38, member 4	1731	0.48
chr7_26833022_26833239	0.20	Cyp2a5	cytochrome P450, family 2, subfamily a, polypeptide 5	2175	0.27
chr15_27444899_27445331	0.20	Gm36899	predicted gene, 36899	18334	0.16
chr16_4586554_4586882	0.20	Glis2	GLIS family zinc finger 2	7995	0.13
chr10_87020834_87020985	0.20	Stab2	stabilin 2	12884	0.16
chr17_7415036_7415292	0.20	Gm6553	predicted gene 6553	15078	0.15
chr7_26781568_26782082	0.20	Cyp2b19	cytochrome P450, family 2, subfamily b, polypeptide 19	15270	0.15
chr2_118874175_118874326	0.20	Ivd	isovaleryl coenzyme A dehydrogenase	57	0.96
chr15_66968663_66969063	0.20	Gm2895	predicted gene 2895	460	0.61
chr5_3596102_3596444	0.19	Rbm48	RNA binding motif protein 48	71	0.49
chr5_111509241_111509406	0.19	C130026L21Rik	RIKEN cDNA C130026L21 gene	72099	0.08
chr15_99865164_99865320	0.19	Lima1	LIM domain and actin binding 1	9429	0.08
chr8_12193585_12193751	0.19	A230072I06Rik	RIKEN cDNA A230072I06 gene	85151	0.08
chr2_32661930_32662135	0.19	Mir1954	microRNA 1954	9703	0.07
chr6_94701073_94701362	0.19	Lrig1	leucine-rich repeats and immunoglobulin-like domains 1	1059	0.59
chr12_85350868_85351019	0.19	Tmed10	transmembrane p24 trafficking protein 10	23	0.96
chr5_139803654_139803817	0.19	Tmem184a	transmembrane protein 184a	4245	0.14
chr4_131041255_131041582	0.19	A930031H19Rik	RIKEN cDNA A930031H19 gene	30944	0.18
chr18_60748821_60749236	0.19	Ndst1	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1	378	0.77
chr11_16832225_16832426	0.19	Egfros	epidermal growth factor receptor, opposite strand	1623	0.42
chr1_45856082_45856244	0.19	Gm5526	predicted pseudogene 5526	1591	0.29
chr1_160904144_160904325	0.19	Rc3h1	RING CCCH (C3H) domains 1	2184	0.15
chr1_46854072_46854237	0.19	Slc39a10	solute carrier family 39 (zinc transporter), member 10	108	0.96
chr10_81320539_81320949	0.19	Cactin	cactin, spliceosome C complex subunit	359	0.64
chr5_28079954_28080114	0.18	Insig1	insulin induced gene 1	5368	0.18
chr11_78697801_78698141	0.18	Nlk	nemo like kinase	598	0.68
chr11_16859692_16859843	0.18	Egfr	epidermal growth factor receptor	18383	0.18
chr9_63698782_63698955	0.18	Smad3	SMAD family member 3	13101	0.22
chr3_144570308_144570468	0.18	Selenof	selenoprotein F	38	0.72
chrX_164419325_164419506	0.18	Piga	phosphatidylinositol glycan anchor biosynthesis, class A	372	0.85
chr7_130631856_130632010	0.18	Tacc2	transforming, acidic coiled-coil containing protein 2	13548	0.17
chr7_25267913_25268075	0.18	Cic	capicua transcriptional repressor	290	0.79
chr18_33437665_33437816	0.18	Nrep	neuronal regeneration related protein	25695	0.18
chr8_35077237_35077419	0.17	Gm34419	predicted gene, 34419	17217	0.16
chr5_73256517_73256913	0.17	Fryl	FRY like transcription coactivator	96	0.94
chr8_69774901_69775060	0.17	Zfp866	zinc finger protein 866	69	0.52
chr2_63862186_63862358	0.17	Fign	fidgetin	235716	0.02
chr6_48444394_48444549	0.17	Zfp467	zinc finger protein 467	435	0.7
chr17_47988159_47988330	0.17	Gm14871	predicted gene 14871	15328	0.13
chr9_78528236_78528545	0.17	Gm47430	predicted gene, 47430	7844	0.14
chr14_25456911_25457241	0.17	Zmiz1os1	Zmiz1 opposite strand 1	722	0.52
chr1_169659535_169659755	0.17	Rgs5	regulator of G-protein signaling 5	4123	0.26
chr5_75143316_75143477	0.17	Olfr1401-ps1	olfactory receptor 1401, pseudogene 1	1838	0.21
chr11_53818731_53818912	0.17	Gm12216	predicted gene 12216	22946	0.11
chr6_127152476_127152648	0.17	Ccnd2	cyclin D2	369	0.76
chr1_89107539_89107745	0.17	Gm38312	predicted gene, 38312	10569	0.21
chr6_125165542_125165892	0.17	Gapdh	glyceraldehyde-3-phosphate dehydrogenase	56	0.92
chr7_130098725_130098937	0.16	Gm23847	predicted gene, 23847	63737	0.12
chr16_38376538_38376695	0.16	Popdc2	popeye domain containing 2	4618	0.14
chr3_88425144_88425305	0.16	Slc25a44	solute carrier family 25, member 44	85	0.91
chr1_168380327_168380548	0.16	Gm38381	predicted gene, 38381	29629	0.18
chrX_163958648_163958821	0.16	Zrsr2	zinc finger (CCCH type), RNA binding motif and serine/arginine rich 2	73	0.98
chr4_57675400_57675766	0.16	Pakap	paralemmin A kinase anchor protein	37608	0.18
chr13_72016997_72017161	0.16	Irx1	Iroquois homeobox 1	53356	0.15
chr13_99794055_99794213	0.16	Gm24471	predicted gene, 24471	101605	0.06
chr16_43303328_43303503	0.16	Gm37946	predicted gene, 37946	4866	0.21
chr8_45626757_45627016	0.16	Sorbs2	sorbin and SH3 domain containing 2	853	0.61
chr1_184732600_184732772	0.16	Hlx	H2.0-like homeobox	67	0.96
chr8_124642015_124642295	0.16	2310022B05Rik	RIKEN cDNA 2310022B05 gene	21214	0.14
chr2_93261940_93262145	0.16	Tspan18	tetraspanin 18	34256	0.17
chr13_34814605_34814934	0.16	Gm47157	predicted gene, 47157	225	0.91
chr17_57214462_57214630	0.16	Mir6978	microRNA 6978	2682	0.16
chr9_107650834_107650985	0.16	Slc38a3	solute carrier family 38, member 3	5111	0.08
chr17_7386060_7386243	0.16	Unc93a2	unc-93 homolog A2	687	0.61
chr16_28851482_28851645	0.16	Mb21d2	Mab-21 domain containing 2	15196	0.27
chr2_26445181_26445721	0.16	Sec16a	SEC16 homolog A, endoplasmic reticulum export factor	235	0.47
chr11_59804844_59804999	0.16	Flcn	folliculin	4667	0.11
chr1_134745790_134746030	0.16	Syt2	synaptotagmin II	2667	0.23
chr11_82035273_82035424	0.16	Ccl2	chemokine (C-C motif) ligand 2	223	0.89
chr10_127668046_127668306	0.16	Nab2	Ngfi-A binding protein 2	392	0.62
chr1_91448793_91448944	0.16	Per2	period circadian clock 2	997	0.4
chr12_86478452_86478665	0.16	Esrrb	estrogen related receptor, beta	8441	0.26
chr7_141458231_141458600	0.16	Pnpla2	patatin-like phospholipase domain containing 2	1397	0.16
chr3_68493989_68494284	0.16	Schip1	schwannomin interacting protein 1	72	0.98
chr3_131564564_131564861	0.16	Papss1	3'-phosphoadenosine 5'-phosphosulfate synthase 1	56	0.98
chr5_150911743_150911914	0.16	Gm43298	predicted gene 43298	29186	0.16
chr18_49832250_49832445	0.16	Dmxl1	Dmx-like 1	323	0.9
chr1_132388072_132388223	0.15	Tmcc2	transmembrane and coiled-coil domains 2	2171	0.22
chr5_139730884_139731070	0.15	Micall2	MICAL-like 2	1857	0.27
chr2_131233930_131234100	0.15	Mavs	mitochondrial antiviral signaling protein	48	0.96
chr5_123135984_123136315	0.15	Gm38102	predicted gene, 38102	388	0.65
chr11_51619519_51619707	0.15	Nhp2	NHP2 ribonucleoprotein	122	0.94
chr19_4240260_4240411	0.15	Pold4	polymerase (DNA-directed), delta 4	7897	0.06
chr8_57487862_57488025	0.15	Sap30	sin3 associated polypeptide	83	0.53
chr8_89279548_89279868	0.15	Gm5356	predicted pseudogene 5356	92148	0.09
chr5_134985683_134985851	0.15	Cldn3	claudin 3	447	0.63
chr12_102788080_102788385	0.15	Gm47042	predicted gene, 47042	23520	0.08
chr7_139388680_139389161	0.15	Inpp5a	inositol polyphosphate-5-phosphatase A	189	0.96
chr19_4719341_4719664	0.15	Sptbn2	spectrin beta, non-erythrocytic 2	1577	0.24
chr2_5951260_5951429	0.15	Upf2	UPF2 regulator of nonsense transcripts homolog (yeast)	125	0.96
chr11_87748776_87748945	0.15	Mir142hg	Mir142 host gene (non-protein coding)	6717	0.09
chr5_147017350_147017528	0.15	Lnx2	ligand of numb-protein X 2	1596	0.37
chr19_22304434_22304587	0.15	Gm22506	predicted gene, 22506	68892	0.12
chr6_29347943_29348124	0.15	Calu	calumenin	36	0.96
chr5_122158077_122158391	0.15	Ppp1cc	protein phosphatase 1 catalytic subunit gamma	44	0.96
chr2_165326498_165326660	0.15	Elmo2	engulfment and cell motility 2	100	0.96
chr3_37158282_37158456	0.15	Gm12532	predicted gene 12532	24516	0.11
chr11_45800072_45800231	0.15	F630206G17Rik	RIKEN cDNA F630206G17 gene	7936	0.16
chr10_80139371_80139556	0.15	Cbarp	calcium channel, voltage-dependent, beta subunit associated regulatory protein	98	0.88
chr4_136035578_136036045	0.14	Rpl11	ribosomal protein L11	7013	0.1
chr13_101746090_101746267	0.14	Gm36638	predicted gene, 36638	5710	0.23
chr3_88296917_88297081	0.14	Tsacc	TSSK6 activating co-chaperone	0	0.59
chr4_149854310_149854480	0.14	Gm47301	predicted gene, 47301	36631	0.09
chr19_57360887_57361068	0.14	Fam160b1	family with sequence similarity 160, member B1	53	0.7
chr19_36731141_36731447	0.14	Ppp1r3c	protein phosphatase 1, regulatory subunit 3C	5359	0.23
chr16_20716658_20716809	0.14	Clcn2	chloride channel, voltage-sensitive 2	569	0.44
chr18_58481759_58481942	0.14	Slc27a6	solute carrier family 27 (fatty acid transporter), member 6	74407	0.12
chr1_171344047_171344210	0.14	Nit1	nitrilase 1	339	0.66
chr6_108065232_108065404	0.14	Setmar	SET domain without mariner transposase fusion	256	0.94
chr10_128337509_128337866	0.14	Cs	citrate synthase	47	0.92
chr12_84772846_84773376	0.14	Npc2	NPC intracellular cholesterol transporter 2	41	0.62
chr3_89391856_89392032	0.14	Gm15417	predicted gene 15417	26	0.6
chr13_67060869_67061048	0.14	Gm46440	predicted gene, 46440	157	0.55
chr4_123411950_123412127	0.14	Macf1	microtubule-actin crosslinking factor 1	190	0.94
chr1_39950143_39950310	0.14	Map4k4	mitogen-activated protein kinase kinase kinase kinase 4	13929	0.22
chr1_168432437_168432592	0.14	Pbx1	pre B cell leukemia homeobox 1	244	0.95
chr11_69996851_69997024	0.14	Phf23	PHD finger protein 23	4	0.92
chr11_51494380_51494743	0.14	Col23a1	collagen, type XXIII, alpha 1	79871	0.07
chr6_124481749_124481909	0.14	C1rl	complement component 1, r subcomponent-like	11284	0.09
chr9_72767021_72767358	0.14	Gm27204	predicted gene 27204	9036	0.12
chr11_106512401_106512774	0.14	Gm22711	predicted gene, 22711	11342	0.15
chr10_77864430_77864592	0.14	Tspear	thrombospondin type laminin G domain and EAR repeats	71	0.91
chr10_88507811_88508139	0.14	Chpt1	choline phosphotransferase 1	3902	0.18
chr5_113024342_113024526	0.14	Grk3	G protein-coupled receptor kinase 3	8643	0.14
chr8_34804694_34804863	0.14	Dusp4	dual specificity phosphatase 4	2519	0.32
chr6_94696254_94696442	0.14	Lrig1	leucine-rich repeats and immunoglobulin-like domains 1	3789	0.28
chr5_118332124_118332291	0.14	Gm28563	predicted gene 28563	65123	0.09
chr2_105396213_105396364	0.14	Rcn1	reticulocalbin 1	940	0.67
chr2_73003161_73003312	0.14	Sp3os	trans-acting transcription factor 3, opposite strand	15995	0.14
chr7_28938830_28938981	0.14	Gm44699	predicted gene 44699	4623	0.12
chr5_24941855_24942029	0.14	Prkag2	protein kinase, AMP-activated, gamma 2 non-catalytic subunit	32965	0.13
chr11_40694837_40695013	0.13	Mat2b	methionine adenosyltransferase II, beta	62	0.97
chr13_55211103_55211935	0.13	Nsd1	nuclear receptor-binding SET-domain protein 1	22	0.97
chr5_23890845_23891003	0.13	AC117663.1	solute carrier family 40 (iron-regulated transporter), member 1 (Slc40a1), pseudogene	14481	0.11
chr9_45268129_45268280	0.13	Il10ra	interleukin 10 receptor, alpha	942	0.35
chr5_137339583_137339751	0.13	Gm43012	predicted gene 43012	2258	0.14
chr2_158168887_158169091	0.13	Tgm2	transglutaminase 2, C polypeptide	22553	0.13

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of Sp2

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:0097503	sialylation(GO:0097503)
0.1	0.2	GO:0021524	visceral motor neuron differentiation(GO:0021524)
0.1	0.2	GO:0008050	female courtship behavior(GO:0008050)
0.1	0.5	GO:0010944	negative regulation of transcription by competitive promoter binding(GO:0010944)
0.1	0.2	GO:0032474	otolith morphogenesis(GO:0032474)
0.1	0.2	GO:0010909	regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010908) positive regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010909) positive regulation of proteoglycan biosynthetic process(GO:1902730)
0.1	0.2	GO:1901097	negative regulation of autophagosome maturation(GO:1901097)
0.1	0.2	GO:0050427	3'-phosphoadenosine 5'-phosphosulfate metabolic process(GO:0050427)
0.1	0.1	GO:2000259	positive regulation of complement activation(GO:0045917) positive regulation of protein activation cascade(GO:2000259)
0.0	0.1	GO:0035964	COPI-coated vesicle budding(GO:0035964)
0.0	0.1	GO:0060528	secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development(GO:0060528)
0.0	0.1	GO:0040031	snRNA modification(GO:0040031)
0.0	0.1	GO:1903800	positive regulation of production of miRNAs involved in gene silencing by miRNA(GO:1903800)
0.0	0.2	GO:0071376	response to corticotropin-releasing hormone(GO:0043435) cellular response to corticotropin-releasing hormone stimulus(GO:0071376)
0.0	0.2	GO:1903849	regulation of aorta morphogenesis(GO:1903847) positive regulation of aorta morphogenesis(GO:1903849)
0.0	0.1	GO:0002434	immune complex clearance(GO:0002434)
0.0	0.2	GO:0000414	regulation of histone H3-K36 methylation(GO:0000414)
0.0	0.1	GO:0016480	negative regulation of transcription from RNA polymerase III promoter(GO:0016480)
0.0	0.2	GO:0006551	leucine metabolic process(GO:0006551)
0.0	0.1	GO:0006556	S-adenosylmethionine biosynthetic process(GO:0006556)
0.0	0.0	GO:1902373	negative regulation of mRNA catabolic process(GO:1902373)
0.0	0.2	GO:0010871	negative regulation of receptor biosynthetic process(GO:0010871)
0.0	0.0	GO:0032907	transforming growth factor beta3 production(GO:0032907) regulation of transforming growth factor beta3 production(GO:0032910)
0.0	0.1	GO:0045658	regulation of neutrophil differentiation(GO:0045658)
0.0	0.1	GO:0042126	nitrate metabolic process(GO:0042126)
0.0	0.1	GO:0006499	N-terminal protein myristoylation(GO:0006499)
0.0	0.2	GO:1903300	negative regulation of glucokinase activity(GO:0033132) negative regulation of hexokinase activity(GO:1903300)
0.0	0.1	GO:0072194	kidney smooth muscle tissue development(GO:0072194)
0.0	0.2	GO:0042796	snRNA transcription from RNA polymerase III promoter(GO:0042796)
0.0	0.1	GO:0002254	kinin cascade(GO:0002254)
0.0	0.1	GO:1902956	regulation of mitochondrial electron transport, NADH to ubiquinone(GO:1902956)
0.0	0.1	GO:0071651	positive regulation of chemokine (C-C motif) ligand 5 production(GO:0071651)
0.0	0.1	GO:0070126	mitochondrial translational termination(GO:0070126)
0.0	0.1	GO:0033634	positive regulation of cell-cell adhesion mediated by integrin(GO:0033634)
0.0	0.1	GO:0051365	cellular response to potassium ion starvation(GO:0051365)
0.0	0.1	GO:1901078	negative regulation of relaxation of muscle(GO:1901078)
0.0	0.1	GO:0061010	gall bladder development(GO:0061010)
0.0	0.1	GO:0072092	ureteric bud invasion(GO:0072092)
0.0	0.1	GO:0031581	hemidesmosome assembly(GO:0031581)
0.0	0.1	GO:0061084	negative regulation of protein refolding(GO:0061084)
0.0	0.1	GO:0090074	negative regulation of protein homodimerization activity(GO:0090074)
0.0	0.1	GO:1901475	pyruvate transmembrane transport(GO:1901475)
0.0	0.1	GO:0035425	autocrine signaling(GO:0035425)
0.0	0.1	GO:1901674	histone H3-K27 acetylation(GO:0043974) regulation of histone H3-K27 acetylation(GO:1901674)
0.0	0.3	GO:0070914	UV-damage excision repair(GO:0070914)
0.0	0.2	GO:0090286	cytoskeletal anchoring at nuclear membrane(GO:0090286)
0.0	0.1	GO:0016576	histone dephosphorylation(GO:0016576)
0.0	0.1	GO:0001831	trophectodermal cellular morphogenesis(GO:0001831)
0.0	0.1	GO:0003415	chondrocyte hypertrophy(GO:0003415)
0.0	0.2	GO:0090527	actin filament reorganization(GO:0090527)
0.0	0.2	GO:0043983	histone H4-K12 acetylation(GO:0043983)
0.0	0.1	GO:0006048	UDP-N-acetylglucosamine biosynthetic process(GO:0006048)
0.0	0.0	GO:1901671	positive regulation of superoxide dismutase activity(GO:1901671) positive regulation of removal of superoxide radicals(GO:1904833)
0.0	0.1	GO:0007221	positive regulation of transcription of Notch receptor target(GO:0007221)
0.0	0.2	GO:0071578	zinc II ion transmembrane import(GO:0071578)
0.0	0.1	GO:0033092	positive regulation of immature T cell proliferation in thymus(GO:0033092)
0.0	0.1	GO:0016344	meiotic chromosome movement towards spindle pole(GO:0016344)
0.0	0.2	GO:0019262	N-acetylneuraminate catabolic process(GO:0019262)
0.0	0.1	GO:1904059	regulation of locomotor rhythm(GO:1904059)
0.0	0.1	GO:0042997	negative regulation of Golgi to plasma membrane protein transport(GO:0042997)
0.0	0.1	GO:0060214	endocardium formation(GO:0060214)
0.0	0.2	GO:0045629	negative regulation of T-helper 2 cell differentiation(GO:0045629)
0.0	0.1	GO:0051342	regulation of cyclic-nucleotide phosphodiesterase activity(GO:0051342)
0.0	0.2	GO:0051561	positive regulation of mitochondrial calcium ion concentration(GO:0051561)
0.0	0.1	GO:1902309	negative regulation of peptidyl-serine dephosphorylation(GO:1902309)
0.0	0.1	GO:0009957	epidermal cell fate specification(GO:0009957)
0.0	0.1	GO:0010626	negative regulation of Schwann cell proliferation(GO:0010626)
0.0	0.1	GO:0002913	positive regulation of T cell anergy(GO:0002669) positive regulation of lymphocyte anergy(GO:0002913)
0.0	0.0	GO:0000720	pyrimidine dimer repair by nucleotide-excision repair(GO:0000720)
0.0	0.1	GO:0017187	peptidyl-glutamic acid carboxylation(GO:0017187)
0.0	0.1	GO:0060266	negative regulation of respiratory burst involved in inflammatory response(GO:0060266)
0.0	0.1	GO:0071677	positive regulation of mononuclear cell migration(GO:0071677)
0.0	0.1	GO:0051562	negative regulation of mitochondrial calcium ion concentration(GO:0051562)
0.0	0.1	GO:0071276	cellular response to cadmium ion(GO:0071276)
0.0	0.1	GO:0048199	vesicle targeting, to, from or within Golgi(GO:0048199)
0.0	0.1	GO:0072262	metanephric glomerular mesangium development(GO:0072223) metanephric glomerular mesangial cell proliferation involved in metanephros development(GO:0072262)
0.0	0.1	GO:0007171	activation of transmembrane receptor protein tyrosine kinase activity(GO:0007171)
0.0	0.1	GO:0032513	negative regulation of protein phosphatase type 2B activity(GO:0032513)
0.0	0.1	GO:0044027	hypermethylation of CpG island(GO:0044027)
0.0	0.2	GO:0006620	posttranslational protein targeting to membrane(GO:0006620)
0.0	0.1	GO:0006285	base-excision repair, AP site formation(GO:0006285)
0.0	0.1	GO:0046125	pyrimidine deoxyribonucleoside metabolic process(GO:0046125)
0.0	0.1	GO:0007256	activation of JNKK activity(GO:0007256)
0.0	0.1	GO:0046084	adenine metabolic process(GO:0046083) adenine biosynthetic process(GO:0046084)
0.0	0.1	GO:0060339	negative regulation of type I interferon-mediated signaling pathway(GO:0060339)
0.0	0.1	GO:0006477	protein sulfation(GO:0006477)
0.0	0.1	GO:0048295	positive regulation of isotype switching to IgE isotypes(GO:0048295)
0.0	0.1	GO:0042091	interleukin-10 biosynthetic process(GO:0042091) regulation of interleukin-10 biosynthetic process(GO:0045074)
0.0	0.4	GO:0030325	adrenal gland development(GO:0030325)
0.0	0.1	GO:0090579	transcriptional activation by promoter-enhancer looping(GO:0071733) gene looping(GO:0090202) dsDNA loop formation(GO:0090579)
0.0	0.1	GO:0006714	sesquiterpenoid metabolic process(GO:0006714)
0.0	0.1	GO:1900454	positive regulation of long term synaptic depression(GO:1900454)
0.0	0.1	GO:0060710	chorio-allantoic fusion(GO:0060710)
0.0	0.1	GO:1904694	negative regulation of vascular smooth muscle contraction(GO:1904694)
0.0	0.0	GO:0060741	prostate gland stromal morphogenesis(GO:0060741)
0.0	0.1	GO:0006543	glutamine catabolic process(GO:0006543)
0.0	0.1	GO:0002681	somatic diversification of T cell receptor genes(GO:0002568) somatic recombination of T cell receptor gene segments(GO:0002681) T cell receptor V(D)J recombination(GO:0033153)
0.0	0.1	GO:0038028	insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028)
0.0	0.0	GO:2000587	regulation of platelet-derived growth factor receptor-beta signaling pathway(GO:2000586) negative regulation of platelet-derived growth factor receptor-beta signaling pathway(GO:2000587)
0.0	0.1	GO:0003347	epicardial cell to mesenchymal cell transition(GO:0003347)
0.0	0.2	GO:0001553	luteinization(GO:0001553)
0.0	0.1	GO:0040016	embryonic cleavage(GO:0040016)
0.0	0.1	GO:0006438	valyl-tRNA aminoacylation(GO:0006438)
0.0	0.1	GO:0045039	protein import into mitochondrial inner membrane(GO:0045039)
0.0	0.1	GO:0051388	positive regulation of neurotrophin TRK receptor signaling pathway(GO:0051388)
0.0	0.1	GO:0000710	meiotic mismatch repair(GO:0000710)
0.0	0.1	GO:0019086	late viral transcription(GO:0019086)
0.0	0.1	GO:0031508	pericentric heterochromatin assembly(GO:0031508)
0.0	0.6	GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:0000184)
0.0	0.0	GO:0051599	response to hydrostatic pressure(GO:0051599)
0.0	0.1	GO:0070212	protein poly-ADP-ribosylation(GO:0070212)
0.0	0.0	GO:0061144	alveolar secondary septum development(GO:0061144)
0.0	0.1	GO:0046951	ketone body biosynthetic process(GO:0046951)
0.0	0.0	GO:1901252	regulation of intracellular transport of viral material(GO:1901252)
0.0	0.1	GO:0051382	kinetochore assembly(GO:0051382)
0.0	0.1	GO:0061635	regulation of protein complex stability(GO:0061635)
0.0	0.0	GO:1903984	positive regulation of TRAIL-activated apoptotic signaling pathway(GO:1903984)
0.0	0.1	GO:0060689	cell differentiation involved in salivary gland development(GO:0060689)
0.0	0.1	GO:0035435	phosphate ion transmembrane transport(GO:0035435)
0.0	0.0	GO:0000965	mitochondrial RNA 3'-end processing(GO:0000965)
0.0	0.1	GO:0032020	ISG15-protein conjugation(GO:0032020)
0.0	0.1	GO:0060830	ciliary receptor clustering involved in smoothened signaling pathway(GO:0060830)
0.0	0.1	GO:1901386	negative regulation of voltage-gated calcium channel activity(GO:1901386)
0.0	0.1	GO:0000185	activation of MAPKKK activity(GO:0000185)
0.0	0.1	GO:0006987	activation of signaling protein activity involved in unfolded protein response(GO:0006987)
0.0	0.0	GO:1902894	negative regulation of pri-miRNA transcription from RNA polymerase II promoter(GO:1902894)
0.0	0.1	GO:0050916	sensory perception of sweet taste(GO:0050916)
0.0	0.0	GO:0006362	transcription elongation from RNA polymerase I promoter(GO:0006362)
0.0	0.1	GO:0006102	isocitrate metabolic process(GO:0006102)
0.0	0.1	GO:0060708	spongiotrophoblast differentiation(GO:0060708)
0.0	0.1	GO:0006369	termination of RNA polymerase II transcription(GO:0006369)
0.0	0.1	GO:0009438	methylglyoxal metabolic process(GO:0009438)
0.0	0.1	GO:0034454	microtubule anchoring at centrosome(GO:0034454)
0.0	0.1	GO:0033136	serine phosphorylation of STAT3 protein(GO:0033136)
0.0	0.1	GO:0000727	double-strand break repair via break-induced replication(GO:0000727)
0.0	0.1	GO:0070966	nuclear-transcribed mRNA catabolic process, no-go decay(GO:0070966)
0.0	0.1	GO:0060534	trachea cartilage development(GO:0060534)
0.0	0.0	GO:1901856	negative regulation of cellular respiration(GO:1901856)
0.0	0.0	GO:1990036	calcium ion import into sarcoplasmic reticulum(GO:1990036)
0.0	0.1	GO:0003383	apical constriction(GO:0003383)
0.0	0.0	GO:0046341	CDP-diacylglycerol metabolic process(GO:0046341)
0.0	0.0	GO:2000384	regulation of ectoderm development(GO:2000383) negative regulation of ectoderm development(GO:2000384)
0.0	0.2	GO:0006107	oxaloacetate metabolic process(GO:0006107)
0.0	0.1	GO:0031293	membrane protein intracellular domain proteolysis(GO:0031293)
0.0	0.1	GO:0060023	soft palate development(GO:0060023)
0.0	0.1	GO:0010756	positive regulation of plasminogen activation(GO:0010756)
0.0	0.1	GO:0035562	negative regulation of chromatin binding(GO:0035562)
0.0	0.0	GO:0060154	cellular process regulating host cell cycle in response to virus(GO:0060154)
0.0	0.0	GO:0090219	negative regulation of lipid kinase activity(GO:0090219)
0.0	0.0	GO:0008588	release of cytoplasmic sequestered NF-kappaB(GO:0008588)
0.0	0.1	GO:0006729	tetrahydrobiopterin biosynthetic process(GO:0006729)
0.0	0.1	GO:0018344	protein geranylgeranylation(GO:0018344)
0.0	0.0	GO:0090069	regulation of ribosome biogenesis(GO:0090069)
0.0	0.0	GO:0006990	positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response(GO:0006990)
0.0	0.0	GO:0097118	neuroligin clustering involved in postsynaptic membrane assembly(GO:0097118)
0.0	0.1	GO:0048069	eye pigmentation(GO:0048069)
0.0	0.1	GO:0034975	protein folding in endoplasmic reticulum(GO:0034975)
0.0	0.0	GO:0090526	regulation of gluconeogenesis involved in cellular glucose homeostasis(GO:0090526)
0.0	0.2	GO:0046854	phosphatidylinositol phosphorylation(GO:0046854)
0.0	0.0	GO:1902083	negative regulation of peptidyl-cysteine S-nitrosylation(GO:1902083)
0.0	0.1	GO:2001185	regulation of CD8-positive, alpha-beta T cell activation(GO:2001185)
0.0	0.1	GO:0046218	tryptophan catabolic process(GO:0006569) tryptophan catabolic process to kynurenine(GO:0019441) indole-containing compound catabolic process(GO:0042436) indolalkylamine catabolic process(GO:0046218)
0.0	0.2	GO:0015936	coenzyme A metabolic process(GO:0015936)
0.0	0.0	GO:1903964	monounsaturated fatty acid metabolic process(GO:1903964) monounsaturated fatty acid biosynthetic process(GO:1903966)
0.0	0.1	GO:2000271	positive regulation of fibroblast apoptotic process(GO:2000271)
0.0	0.1	GO:0046855	inositol phosphate dephosphorylation(GO:0046855)
0.0	0.1	GO:0016338	calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338)
0.0	0.0	GO:0065001	specification of axis polarity(GO:0065001)
0.0	0.0	GO:0010025	wax biosynthetic process(GO:0010025) wax metabolic process(GO:0010166)
0.0	0.0	GO:1901740	negative regulation of myoblast fusion(GO:1901740)
0.0	0.0	GO:0032025	response to cobalt ion(GO:0032025)
0.0	0.0	GO:0033629	negative regulation of cell adhesion mediated by integrin(GO:0033629)
0.0	0.1	GO:0034392	negative regulation of smooth muscle cell apoptotic process(GO:0034392)
0.0	0.1	GO:0000188	inactivation of MAPK activity(GO:0000188)
0.0	0.1	GO:0072257	metanephric nephron tubule epithelial cell differentiation(GO:0072257) regulation of metanephric nephron tubule epithelial cell differentiation(GO:0072307)
0.0	0.0	GO:0048388	endosomal lumen acidification(GO:0048388)
0.0	0.0	GO:0018894	dibenzo-p-dioxin metabolic process(GO:0018894)
0.0	0.1	GO:0071557	histone H3-K27 demethylation(GO:0071557)
0.0	0.0	GO:0042138	meiotic DNA double-strand break formation(GO:0042138)
0.0	0.0	GO:0033762	response to glucagon(GO:0033762)
0.0	0.0	GO:0060336	negative regulation of response to interferon-gamma(GO:0060331) negative regulation of interferon-gamma-mediated signaling pathway(GO:0060336)
0.0	0.1	GO:0097284	hepatocyte apoptotic process(GO:0097284)
0.0	0.0	GO:0009838	abscission(GO:0009838)
0.0	0.1	GO:0030214	hyaluronan catabolic process(GO:0030214)
0.0	0.1	GO:0018298	protein-chromophore linkage(GO:0018298)
0.0	0.0	GO:0035887	aortic smooth muscle cell differentiation(GO:0035887)
0.0	0.0	GO:0045964	positive regulation of catecholamine metabolic process(GO:0045915) positive regulation of dopamine metabolic process(GO:0045964)
0.0	0.0	GO:0070601	centromeric sister chromatid cohesion(GO:0070601)
0.0	0.1	GO:0006689	ganglioside catabolic process(GO:0006689)
0.0	0.0	GO:0051572	negative regulation of histone H3-K4 methylation(GO:0051572)
0.0	0.0	GO:0000379	tRNA-type intron splice site recognition and cleavage(GO:0000379)
0.0	0.0	GO:2000346	negative regulation of hepatocyte proliferation(GO:2000346)
0.0	0.0	GO:0002870	lymphocyte anergy(GO:0002249) regulation of T cell anergy(GO:0002667) T cell anergy(GO:0002870) regulation of lymphocyte anergy(GO:0002911)
0.0	0.1	GO:0043313	regulation of neutrophil degranulation(GO:0043313)
0.0	0.0	GO:0035279	mRNA cleavage involved in gene silencing by miRNA(GO:0035279) mRNA cleavage involved in gene silencing(GO:0098795)
0.0	0.1	GO:0006851	mitochondrial calcium ion transport(GO:0006851)
0.0	0.0	GO:1900095	regulation of dosage compensation by inactivation of X chromosome(GO:1900095)
0.0	0.1	GO:0075522	IRES-dependent viral translational initiation(GO:0075522)
0.0	0.0	GO:0016103	diterpenoid catabolic process(GO:0016103) retinoic acid catabolic process(GO:0034653)
0.0	0.0	GO:0018992	germ-line sex determination(GO:0018992)
0.0	0.0	GO:2000686	regulation of rubidium ion transmembrane transporter activity(GO:2000686)
0.0	0.0	GO:0046874	quinolinate metabolic process(GO:0046874)
0.0	0.1	GO:0030388	fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.0	0.0	GO:0033353	S-adenosylmethionine cycle(GO:0033353)
0.0	0.0	GO:0006566	threonine metabolic process(GO:0006566)
0.0	0.0	GO:0030202	heparin metabolic process(GO:0030202)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:0031465	Cul4B-RING E3 ubiquitin ligase complex(GO:0031465)
0.1	0.2	GO:0070765	gamma-secretase complex(GO:0070765)
0.1	0.2	GO:0097487	multivesicular body, internal vesicle(GO:0097487)
0.1	0.2	GO:0097452	GAIT complex(GO:0097452)
0.1	0.2	GO:1990907	beta-catenin-TCF complex(GO:1990907)
0.0	0.2	GO:0035363	histone locus body(GO:0035363)
0.0	0.1	GO:0090661	box H/ACA telomerase RNP complex(GO:0090661)
0.0	0.2	GO:0089701	U2AF(GO:0089701)
0.0	0.1	GO:0044299	C-fiber(GO:0044299)
0.0	0.1	GO:0005606	laminin-1 complex(GO:0005606)
0.0	0.1	GO:0072487	MSL complex(GO:0072487)
0.0	0.1	GO:0070876	SOSS complex(GO:0070876)
0.0	0.1	GO:0032777	Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.0	0.1	GO:0042719	mitochondrial intermembrane space protein transporter complex(GO:0042719)
0.0	0.1	GO:0005968	Rab-protein geranylgeranyltransferase complex(GO:0005968)
0.0	0.2	GO:0034992	microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.0	0.1	GO:0043293	apoptosome(GO:0043293)
0.0	0.1	GO:0005971	ribonucleoside-diphosphate reductase complex(GO:0005971)
0.0	0.1	GO:0005958	DNA-dependent protein kinase-DNA ligase 4 complex(GO:0005958)
0.0	0.2	GO:0001650	fibrillar center(GO:0001650)
0.0	0.4	GO:0035145	exon-exon junction complex(GO:0035145)
0.0	0.0	GO:0000110	nucleotide-excision repair factor 1 complex(GO:0000110)
0.0	0.1	GO:0044294	dendritic growth cone(GO:0044294)
0.0	0.2	GO:0016580	Sin3 complex(GO:0016580)
0.0	0.1	GO:0031415	NatA complex(GO:0031415)
0.0	0.0	GO:0005956	protein kinase CK2 complex(GO:0005956)
0.0	0.1	GO:0005638	lamin filament(GO:0005638)
0.0	0.1	GO:0070820	tertiary granule(GO:0070820)
0.0	0.1	GO:0031298	replication fork protection complex(GO:0031298)
0.0	0.1	GO:0030056	hemidesmosome(GO:0030056)
0.0	0.1	GO:0042825	TAP complex(GO:0042825)
0.0	0.0	GO:0032127	dense core granule membrane(GO:0032127)
0.0	0.1	GO:0016281	eukaryotic translation initiation factor 4F complex(GO:0016281)
0.0	0.2	GO:0005779	integral component of peroxisomal membrane(GO:0005779)
0.0	0.1	GO:0070937	CRD-mediated mRNA stability complex(GO:0070937)
0.0	0.0	GO:0071797	LUBAC complex(GO:0071797)
0.0	0.0	GO:0032937	SREBP-SCAP-Insig complex(GO:0032937)
0.0	0.1	GO:0005964	phosphorylase kinase complex(GO:0005964)
0.0	0.0	GO:0097413	Lewy body(GO:0097413)
0.0	0.1	GO:0030991	intraciliary transport particle A(GO:0030991)
0.0	0.1	GO:0031588	nucleotide-activated protein kinase complex(GO:0031588)
0.0	0.0	GO:0033269	internode region of axon(GO:0033269)
0.0	0.0	GO:0034679	integrin alpha9-beta1 complex(GO:0034679)
0.0	0.1	GO:0072357	PTW/PP1 phosphatase complex(GO:0072357)
0.0	0.0	GO:0035867	alphav-beta3 integrin-IGF-1-IGF1R complex(GO:0035867)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.5	GO:0043426	MRF binding(GO:0043426)
0.1	0.3	GO:0003828	alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)
0.1	0.2	GO:0004886	9-cis retinoic acid receptor activity(GO:0004886)
0.1	0.2	GO:0048408	epidermal growth factor binding(GO:0048408)
0.1	0.2	GO:0071535	RING-like zinc finger domain binding(GO:0071535)
0.1	0.2	GO:0043891	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity(GO:0004365) glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity(GO:0043891)
0.0	0.1	GO:0034513	box H/ACA snoRNA binding(GO:0034513)
0.0	0.2	GO:0004046	aminoacylase activity(GO:0004046)
0.0	0.1	GO:0016149	translation release factor activity, codon specific(GO:0016149)
0.0	0.2	GO:0004887	thyroid hormone receptor activity(GO:0004887)
0.0	0.2	GO:0015016	[heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.0	0.2	GO:0042731	PH domain binding(GO:0042731)
0.0	0.0	GO:0015440	peptide-transporting ATPase activity(GO:0015440)
0.0	0.3	GO:0004779	sulfate adenylyltransferase activity(GO:0004779)
0.0	0.1	GO:0031727	CCR2 chemokine receptor binding(GO:0031727)
0.0	0.1	GO:0030628	pre-mRNA 3'-splice site binding(GO:0030628)
0.0	0.1	GO:0004699	calcium-independent protein kinase C activity(GO:0004699)
0.0	0.1	GO:0015186	L-asparagine transmembrane transporter activity(GO:0015182) L-glutamine transmembrane transporter activity(GO:0015186)
0.0	0.1	GO:0019237	centromeric DNA binding(GO:0019237)
0.0	0.1	GO:0046912	transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
0.0	0.1	GO:0050833	pyruvate transmembrane transporter activity(GO:0050833)
0.0	0.1	GO:0008381	mechanically-gated ion channel activity(GO:0008381) mechanically gated channel activity(GO:0022833)
0.0	0.1	GO:0072345	NAADP-sensitive calcium-release channel activity(GO:0072345)
0.0	0.1	GO:0008158	hedgehog receptor activity(GO:0008158)
0.0	0.1	GO:0042296	ISG15 transferase activity(GO:0042296)
0.0	0.1	GO:0003886	DNA (cytosine-5-)-methyltransferase activity(GO:0003886) DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates(GO:0051718)
0.0	0.1	GO:0004748	ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.0	0.1	GO:0046975	histone methyltransferase activity (H3-K36 specific)(GO:0046975)
0.0	0.2	GO:0004445	inositol-polyphosphate 5-phosphatase activity(GO:0004445)
0.0	0.1	GO:0052724	inositol hexakisphosphate kinase activity(GO:0000828) inositol hexakisphosphate 5-kinase activity(GO:0000832) inositol hexakisphosphate 1-kinase activity(GO:0052723) inositol hexakisphosphate 3-kinase activity(GO:0052724)
0.0	0.1	GO:0019136	deoxynucleoside kinase activity(GO:0019136)
0.0	0.1	GO:0050700	CARD domain binding(GO:0050700)
0.0	0.1	GO:0050693	LBD domain binding(GO:0050693)
0.0	0.1	GO:0005007	fibroblast growth factor-activated receptor activity(GO:0005007)
0.0	0.1	GO:0003918	DNA topoisomerase type II (ATP-hydrolyzing) activity(GO:0003918) DNA topoisomerase II activity(GO:0061505)
0.0	0.1	GO:0097322	7SK snRNA binding(GO:0097322)
0.0	0.1	GO:0046979	TAP1 binding(GO:0046978) TAP2 binding(GO:0046979)
0.0	0.1	GO:0005173	stem cell factor receptor binding(GO:0005173)
0.0	0.1	GO:0061513	hexose phosphate transmembrane transporter activity(GO:0015119) organophosphate:inorganic phosphate antiporter activity(GO:0015315) hexose-phosphate:inorganic phosphate antiporter activity(GO:0015526) glucose 6-phosphate:inorganic phosphate antiporter activity(GO:0061513)
0.0	0.1	GO:0016861	intramolecular oxidoreductase activity, interconverting aldoses and ketoses(GO:0016861)
0.0	0.1	GO:0004332	fructose-bisphosphate aldolase activity(GO:0004332)
0.0	0.1	GO:0032564	dATP binding(GO:0032564)
0.0	0.1	GO:0004832	valine-tRNA ligase activity(GO:0004832)
0.0	0.0	GO:0032422	purine-rich negative regulatory element binding(GO:0032422)
0.0	0.1	GO:0000014	single-stranded DNA endodeoxyribonuclease activity(GO:0000014)
0.0	0.1	GO:0004128	cytochrome-b5 reductase activity, acting on NAD(P)H(GO:0004128)
0.0	0.1	GO:0003810	protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.0	0.1	GO:0031800	type 3 metabotropic glutamate receptor binding(GO:0031800)
0.0	0.1	GO:0016743	carboxyl- or carbamoyltransferase activity(GO:0016743)
0.0	0.4	GO:0050681	androgen receptor binding(GO:0050681)
0.0	0.1	GO:0004563	beta-N-acetylhexosaminidase activity(GO:0004563)
0.0	0.2	GO:0016854	racemase and epimerase activity(GO:0016854)
0.0	0.3	GO:0052890	oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor(GO:0052890)
0.0	0.0	GO:0031826	type 2A serotonin receptor binding(GO:0031826)
0.0	0.1	GO:0051864	histone demethylase activity (H3-K36 specific)(GO:0051864)
0.0	0.1	GO:0008020	G-protein coupled photoreceptor activity(GO:0008020)
0.0	0.1	GO:0044323	retinoic acid-responsive element binding(GO:0044323)
0.0	0.0	GO:0004920	interleukin-10 receptor activity(GO:0004920)
0.0	0.1	GO:0016899	oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor(GO:0016899)
0.0	0.1	GO:0043208	glycosphingolipid binding(GO:0043208)
0.0	0.0	GO:0008309	double-stranded DNA exodeoxyribonuclease activity(GO:0008309)
0.0	0.0	GO:0034893	mono-butyltin dioxygenase activity(GO:0018586) tri-n-butyltin dioxygenase activity(GO:0018588) di-n-butyltin dioxygenase activity(GO:0018589) methylsilanetriol hydroxylase activity(GO:0018590) methyl tertiary butyl ether 3-monooxygenase activity(GO:0018591) 4-nitrocatechol 4-monooxygenase activity(GO:0018592) 4-chlorophenoxyacetate monooxygenase activity(GO:0018593) tert-butanol 2-monooxygenase activity(GO:0018594) alpha-pinene monooxygenase activity(GO:0018595) dimethylsilanediol hydroxylase activity(GO:0018596) ammonia monooxygenase activity(GO:0018597) hydroxymethylsilanetriol oxidase activity(GO:0018598) 2-hydroxyisobutyrate 3-monooxygenase activity(GO:0018599) alpha-pinene dehydrogenase activity(GO:0018600) bisphenol A hydroxylase B activity(GO:0034559) 2,2-bis(4-hydroxyphenyl)-1-propanol hydroxylase activity(GO:0034562) 9-fluorenone-3,4-dioxygenase activity(GO:0034786) anthracene 9,10-dioxygenase activity(GO:0034816) 2-(methylthio)benzothiazole monooxygenase activity(GO:0034857) 2-hydroxybenzothiazole monooxygenase activity(GO:0034858) benzothiazole monooxygenase activity(GO:0034859) 2,6-dihydroxybenzothiazole monooxygenase activity(GO:0034862) pinacolone 5-monooxygenase activity(GO:0034870) thioacetamide S-oxygenase activity(GO:0034873) thioacetamide S-oxide S-oxygenase activity(GO:0034874) endosulfan monooxygenase I activity(GO:0034888) N-nitrodimethylamine hydroxylase activity(GO:0034893) 4-(1-ethyl-1,4-dimethyl-pentyl)phenol monoxygenase activity(GO:0034897) endosulfan ether monooxygenase activity(GO:0034903) pyrene 4,5-monooxygenase activity(GO:0034925) pyrene 1,2-monooxygenase activity(GO:0034927) 1-hydroxypyrene 6,7-monooxygenase activity(GO:0034928) 1-hydroxypyrene 7,8-monooxygenase activity(GO:0034929) phenylboronic acid monooxygenase activity(GO:0034950) spheroidene monooxygenase activity(GO:0043823)
0.0	0.1	GO:0048273	mitogen-activated protein kinase p38 binding(GO:0048273)
0.0	0.2	GO:0004602	glutathione peroxidase activity(GO:0004602)
0.0	0.0	GO:0004013	adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.0	0.0	GO:0004605	phosphatidate cytidylyltransferase activity(GO:0004605)
0.0	0.1	GO:0015375	glycine:sodium symporter activity(GO:0015375)
0.0	0.0	GO:0003986	acetyl-CoA hydrolase activity(GO:0003986)
0.0	0.1	GO:0016833	oxo-acid-lyase activity(GO:0016833)
0.0	0.4	GO:0042162	telomeric DNA binding(GO:0042162)
0.0	0.0	GO:0017098	sulfonylurea receptor binding(GO:0017098)
0.0	0.0	GO:0035033	histone deacetylase regulator activity(GO:0035033)
0.0	0.0	GO:0071558	histone demethylase activity (H3-K27 specific)(GO:0071558)
0.0	0.2	GO:0045295	gamma-catenin binding(GO:0045295)
0.0	0.1	GO:0000213	tRNA-intron endonuclease activity(GO:0000213)
0.0	0.0	GO:0032896	palmitoyl-CoA 9-desaturase activity(GO:0032896)
0.0	0.1	GO:0003910	DNA ligase activity(GO:0003909) DNA ligase (ATP) activity(GO:0003910)
0.0	0.0	GO:0034714	type III transforming growth factor beta receptor binding(GO:0034714)
0.0	0.1	GO:0005432	calcium:sodium antiporter activity(GO:0005432)
0.0	0.4	GO:0001102	RNA polymerase II activating transcription factor binding(GO:0001102)
0.0	0.4	GO:0030507	spectrin binding(GO:0030507)
0.0	0.0	GO:0043533	inositol 1,3,4,5 tetrakisphosphate binding(GO:0043533)
0.0	0.0	GO:0004793	threonine aldolase activity(GO:0004793) L-allo-threonine aldolase activity(GO:0008732)
0.0	0.1	GO:0019784	NEDD8-specific protease activity(GO:0019784)
0.0	0.1	GO:0004689	phosphorylase kinase activity(GO:0004689)
0.0	0.0	GO:0004461	lactose synthase activity(GO:0004461)
0.0	0.0	GO:0015205	purine nucleobase transmembrane transporter activity(GO:0005345) pyrimidine nucleobase transmembrane transporter activity(GO:0005350) nucleobase transmembrane transporter activity(GO:0015205)
0.0	0.1	GO:0008239	dipeptidyl-peptidase activity(GO:0008239)
0.0	0.4	GO:0003684	damaged DNA binding(GO:0003684)
0.0	0.0	GO:0016715	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen(GO:0016715)
0.0	0.1	GO:0005521	lamin binding(GO:0005521)
0.0	0.0	GO:1901612	cardiolipin binding(GO:1901612)

Gene overrepresentation in curated gene sets: canonical pathways category:

Total log-likelihood	Term	Description
0.6	PID RXR VDR PATHWAY	RXR and RAR heterodimerization with other nuclear receptor
0.3	PID CIRCADIAN PATHWAY	Circadian rhythm pathway
0.2	PID SYNDECAN 3 PATHWAY	Syndecan-3-mediated signaling events
0.1	PID IL5 PATHWAY	IL5-mediated signaling events
0.2	PID ERB GENOMIC PATHWAY	Validated nuclear estrogen receptor beta network
0.3	PID INSULIN GLUCOSE PATHWAY	Insulin-mediated glucose transport
0.1	PID RANBP2 PATHWAY	Sumoylation by RanBP2 regulates transcriptional repression
0.7	PID HIF1 TFPATHWAY	HIF-1-alpha transcription factor network
0.1	ST TYPE I INTERFERON PATHWAY	Type I Interferon (alpha/beta IFN) Pathway
0.2	PID EPO PATHWAY	EPO signaling pathway
0.1	SA G2 AND M PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Total log-likelihood	Term	Description
1.1	REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION	Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.4	REACTOME N GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS GOLGI	Genes involved in N-glycan antennae elongation in the medial/trans-Golgi
0.0	REACTOME PEPTIDE CHAIN ELONGATION	Genes involved in Peptide chain elongation
0.2	REACTOME NFKB ACTIVATION THROUGH FADD RIP1 PATHWAY MEDIATED BY CASPASE 8 AND10	Genes involved in NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
0.4	REACTOME ELONGATION ARREST AND RECOVERY	Genes involved in Elongation arrest and recovery
0.3	REACTOME ZINC TRANSPORTERS	Genes involved in Zinc transporters
0.2	REACTOME REGULATION OF COMPLEMENT CASCADE	Genes involved in Regulation of Complement cascade
0.1	REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES	Genes involved in Cytosolic sulfonation of small molecules
0.2	REACTOME REGULATION OF KIT SIGNALING	Genes involved in Regulation of KIT signaling
0.1	REACTOME OPSINS	Genes involved in Opsins
0.2	REACTOME NOTCH HLH TRANSCRIPTION PATHWAY	Genes involved in Notch-HLH transcription pathway
0.2	REACTOME REGULATION OF AMPK ACTIVITY VIA LKB1	Genes involved in Regulation of AMPK activity via LKB1
0.3	REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING	Genes involved in Downregulation of TGF-beta receptor signaling
0.1	REACTOME RNA POL I PROMOTER OPENING	Genes involved in RNA Polymerase I Promoter Opening
0.5	REACTOME GAB1 SIGNALOSOME	Genes involved in GAB1 signalosome
0.1	REACTOME PROLACTIN RECEPTOR SIGNALING	Genes involved in Prolactin receptor signaling
0.3	REACTOME GLYCOLYSIS	Genes involved in Glycolysis
0.0	REACTOME TGF BETA RECEPTOR SIGNALING ACTIVATES SMADS	Genes involved in TGF-beta receptor signaling activates SMADs
0.1	REACTOME ERKS ARE INACTIVATED	Genes involved in ERKs are inactivated
0.1	REACTOME TRYPTOPHAN CATABOLISM	Genes involved in Tryptophan catabolism
0.2	REACTOME SIGNALING BY HIPPO	Genes involved in Signaling by Hippo
0.1	REACTOME ALPHA LINOLENIC ACID ALA METABOLISM	Genes involved in alpha-linolenic acid (ALA) metabolism
0.1	REACTOME TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION	Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
0.1	REACTOME INTEGRATION OF PROVIRUS	Genes involved in Integration of provirus
0.0	REACTOME INTEGRATION OF ENERGY METABOLISM	Genes involved in Integration of energy metabolism