Project

ENCSR904DTN: DNase-seq of mouse liver in constant darkness

Navigation

Downloads

CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for Spdef

Z-value: 1.07

Motif logo

Transcription factors associated with Spdef

Gene Symbol	Gene ID	Gene Info
Spdef Ensembl NCBI MGI UniProt	ENSMUSG00000024215.7	Spdef

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

Gene	Promoter	Distance	Association probability	Pearson corr. coef.	P-value	Plot
Spdef	chr17_27716973_27717159	653	0.588600	-0.89	1.7e-02	Click!
Spdef	chr17_27716769_27716920	875	0.465415	-0.65	1.6e-01	Click!
Spdef	chr17_27721382_27721552	3118	0.160414	0.35	4.9e-01	Click!
Spdef	chr17_27717560_27717711	84	0.952160	-0.31	5.5e-01	Click!

Activity of the Spdef motif across conditions

Conditions sorted by the z-value of the Spdef motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr7_97413837_97414007	0.55	Thrsp	thyroid hormone responsive	3597	0.16
chr12_4220651_4220920	0.44	Gm48210	predicted gene, 48210	1317	0.27
chr17_84226805_84226999	0.42	Thada	thyroid adenoma associated	2958	0.24
chr16_45377470_45377621	0.37	Cd200	CD200 antigen	22767	0.16
chr1_67134415_67135075	0.34	Cps1	carbamoyl-phosphate synthetase 1	11719	0.24
chr11_16844975_16845160	0.33	Egfros	epidermal growth factor receptor, opposite strand	14365	0.2
chr17_8797635_8797786	0.32	Pde10a	phosphodiesterase 10A	3983	0.29
chr4_63355986_63356174	0.31	Orm3	orosomucoid 3	82	0.95
chr14_28998848_28998999	0.30	Gm23999	predicted gene, 23999	10876	0.19
chr6_88003582_88003770	0.30	4933412L11Rik	RIKEN cDNA 4933412L11 gene	9497	0.09
chr14_52012195_52012346	0.29	Zfp219	zinc finger protein 219	1388	0.21
chr5_43146388_43146587	0.29	Gm42552	predicted gene 42552	1840	0.38
chr3_69280240_69280391	0.29	Ppm1l	protein phosphatase 1 (formerly 2C)-like	36546	0.13
chr3_31970158_31970309	0.28	Gm37834	predicted gene, 37834	15469	0.27
chr12_4220183_4220334	0.27	Gm48210	predicted gene, 48210	1844	0.19
chr9_122849425_122849576	0.27	Gm47140	predicted gene, 47140	1082	0.34
chr2_72741921_72742104	0.27	6430710C18Rik	RIKEN cDNA 6430710C18 gene	8841	0.22
chr12_103991999_103992602	0.27	Serpina11	serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 11	2343	0.16
chr5_50031875_50032113	0.26	Adgra3	adhesion G protein-coupled receptor A3	21385	0.19
chr9_46092730_46092881	0.26	Sik3	SIK family kinase 3	30325	0.14
chr16_43330685_43330836	0.25	Gm15711	predicted gene 15711	18166	0.16
chr6_146751805_146751963	0.25	Gm44270	predicted gene, 44270	10697	0.14
chr4_63350215_63350540	0.25	Gm11212	predicted gene 11212	34	0.96
chr8_76148232_76148470	0.25	Gm45742	predicted gene 45742	31324	0.21
chr7_35748679_35748830	0.25	Dpy19l3	dpy-19-like 3 (C. elegans)	5601	0.2
chr19_11977402_11977711	0.25	Osbp	oxysterol binding protein	11615	0.09
chr6_137773601_137773762	0.24	Dera	deoxyribose-phosphate aldolase (putative)	1308	0.52
chr3_94702452_94702603	0.24	Selenbp2	selenium binding protein 2	8868	0.11
chr10_40502877_40503043	0.22	Gm18671	predicted gene, 18671	45932	0.12
chr6_38144404_38144577	0.22	D630045J12Rik	RIKEN cDNA D630045J12 gene	2884	0.23
chr19_44399974_44400175	0.22	Scd1	stearoyl-Coenzyme A desaturase 1	6616	0.15
chr5_125040097_125040498	0.22	Ncor2	nuclear receptor co-repressor 2	2515	0.25
chr1_71735697_71735877	0.22	Gm5256	predicted gene 5256	20863	0.17
chr3_97635501_97635936	0.21	Fmo5	flavin containing monooxygenase 5	6835	0.14
chr1_88248965_88249116	0.21	Mroh2a	maestro heat-like repeat family member 2A	8718	0.09
chr11_120810230_120810550	0.21	Fasn	fatty acid synthase	689	0.48
chr16_43234125_43234650	0.21	Zbtb20	zinc finger and BTB domain containing 20	1493	0.45
chr17_35254998_35255149	0.21	Mir8094	microRNA 8094	3784	0.06
chr12_104088559_104088873	0.20	Serpina4-ps1	serine (or cysteine) peptidase inhibitor, clade A, member 4, pseudogene 1	8067	0.1
chr11_119007787_119007988	0.19	Cbx2	chromobox 2	15075	0.15
chr19_25422520_25422717	0.19	Kank1	KN motif and ankyrin repeat domains 1	379	0.88
chr9_74228469_74228620	0.19	Wdr72	WD repeat domain 72	45590	0.18
chr2_112595326_112595515	0.19	Gm44374	predicted gene, 44374	18610	0.17
chr11_16791951_16792316	0.19	Egfros	epidermal growth factor receptor, opposite strand	38569	0.14
chr13_101718863_101719071	0.19	Pik3r1	phosphoinositide-3-kinase regulatory subunit 1	16863	0.2
chr5_122320103_122320299	0.19	Gm15842	predicted gene 15842	17779	0.09
chr18_12692319_12692517	0.19	Ttc39c	tetratricopeptide repeat domain 39C	2690	0.21
chr2_58761406_58761587	0.18	Upp2	uridine phosphorylase 2	3829	0.24
chr4_154297797_154298168	0.18	Arhgef16	Rho guanine nucleotide exchange factor (GEF) 16	1910	0.29
chr19_34270258_34270414	0.18	Gm50239	predicted gene, 50239	14201	0.14
chr10_42708978_42709129	0.18	Gm15200	predicted gene 15200	10535	0.18
chr7_123643560_123643752	0.18	Zkscan2	zinc finger with KRAB and SCAN domains 2	143207	0.04
chr3_94705046_94705225	0.18	Selenbp2	selenium binding protein 2	11476	0.11
chr2_58761173_58761336	0.18	Upp2	uridine phosphorylase 2	4071	0.24
chr12_104740709_104740870	0.18	Dicer1	dicer 1, ribonuclease type III	1952	0.38
chr17_28016505_28016679	0.18	Anks1	ankyrin repeat and SAM domain containing 1	9247	0.12
chr11_60196823_60197490	0.18	Mir6921	microRNA 6921	3461	0.14
chr6_24046716_24047018	0.17	Slc13a1	solute carrier family 13 (sodium/sulfate symporters), member 1	61704	0.12
chr10_128206622_128206773	0.17	Gls2	glutaminase 2 (liver, mitochondrial)	228	0.82
chr11_5906758_5906909	0.17	Gck	glucokinase	4746	0.13
chr10_4731451_4731623	0.17	Esr1	estrogen receptor 1 (alpha)	18886	0.26
chr11_60202909_60203232	0.17	Srebf1	sterol regulatory element binding transcription factor 1	418	0.59
chr2_30144800_30144973	0.17	Tbc1d13	TBC1 domain family, member 13	2607	0.15
chr9_121881807_121881992	0.17	Gm47113	predicted gene, 47113	12403	0.08
chr3_21986159_21986455	0.17	Gm43674	predicted gene 43674	12161	0.21
chr8_104831387_104831616	0.17	Ces2b	carboxyesterase 2B	71	0.94
chr5_87562697_87562848	0.17	Sult1d1	sulfotransferase family 1D, member 1	2581	0.17
chr7_72260804_72260982	0.17	Mctp2	multiple C2 domains, transmembrane 2	31533	0.22
chr12_70720580_70720731	0.17	Gm32369	predicted gene, 32369	38805	0.12
chr2_91750560_91750711	0.16	Ambra1	autophagy/beclin 1 regulator 1	15810	0.14
chr11_60816993_60817396	0.16	Gm12611	predicted gene 12611	819	0.38
chr19_44397890_44398071	0.16	Scd1	stearoyl-Coenzyme A desaturase 1	8710	0.15
chr18_12711826_12711991	0.16	Mir1948	microRNA 1948	2903	0.2
chr12_86826629_86826835	0.16	Gm10095	predicted gene 10095	19735	0.17
chr9_21838672_21838867	0.16	Angptl8	angiopoietin-like 8	3259	0.14
chr4_63348935_63349236	0.16	Gm11212	predicted gene 11212	1326	0.29
chr2_181522503_181522654	0.16	Dnajc5	DnaJ heat shock protein family (Hsp40) member C5	1631	0.22
chr10_58228380_58228585	0.16	Gm10807	predicted gene 10807	169	0.92
chr10_99171877_99172060	0.16	Poc1b	POC1 centriolar protein B	684	0.6
chr7_116183557_116183712	0.16	Plekha7	pleckstrin homology domain containing, family A member 7	881	0.63
chr12_75448996_75449191	0.16	Gphb5	glycoprotein hormone beta 5	32312	0.18
chr17_46073702_46073982	0.16	Gm36200	predicted gene, 36200	10424	0.13
chr8_82255910_82256078	0.16	Gm38590	predicted gene, 38590	48459	0.15
chr14_65615417_65615662	0.15	Nuggc	nuclear GTPase, germinal center associated	10272	0.2
chr9_116185819_116186009	0.15	Gm4668	predicted gene 4668	3266	0.22
chr4_152264194_152264355	0.15	Gpr153	G protein-coupled receptor 153	9958	0.12
chr5_90468289_90468670	0.15	Alb	albumin	5779	0.16
chr3_27704926_27705320	0.15	Fndc3b	fibronectin type III domain containing 3B	5275	0.31
chr6_97962459_97962619	0.15	Mitf	melanogenesis associated transcription factor	21621	0.24
chr13_23298661_23298830	0.15	Gm11333	predicted gene 11333	696	0.46
chr10_114191151_114191309	0.15	Gm48104	predicted gene, 48104	95503	0.09
chr4_32290238_32290389	0.15	Bach2it1	BTB and CNC homology 2, intronic transcript 1	38552	0.16
chr13_108338110_108338518	0.15	Depdc1b	DEP domain containing 1B	11786	0.18
chr4_45800098_45800462	0.15	Aldh1b1	aldehyde dehydrogenase 1 family, member B1	1159	0.41
chr14_17768072_17768293	0.15	Gm48320	predicted gene, 48320	2940	0.39
chr2_156722367_156722542	0.14	Dlgap4	DLG associated protein 4	962	0.41
chr10_8230404_8230563	0.14	Gm30906	predicted gene, 30906	54352	0.15
chr8_34164335_34164526	0.14	Mir6395	microRNA 6395	2282	0.18
chr14_21181187_21181360	0.14	Adk	adenosine kinase	105121	0.06
chr4_97885463_97885690	0.14	Nfia	nuclear factor I/A	5457	0.31
chr6_28423868_28424057	0.14	Gcc1	golgi coiled coil 1	191	0.56
chr7_28957656_28957827	0.14	Actn4	actinin alpha 4	4482	0.12
chr8_84723903_84724146	0.14	G430095P16Rik	RIKEN cDNA G430095P16 gene	1017	0.36
chr11_16880492_16880986	0.14	Egfr	epidermal growth factor receptor	2589	0.29
chr9_120133572_120133723	0.14	Gm5922	predicted gene 5922	1368	0.2
chr7_106236793_106236971	0.14	Gvin1	GTPase, very large interferon inducible 1	21556	0.16
chr4_72398261_72398417	0.14	Gm11235	predicted gene 11235	144327	0.05
chr11_16816779_16816940	0.14	Egfros	epidermal growth factor receptor, opposite strand	13843	0.21
chr17_43242727_43242878	0.14	Adgrf1	adhesion G protein-coupled receptor F1	27527	0.22
chr17_86552135_86552300	0.14	Gm10309	predicted gene 10309	46985	0.15
chr1_153862795_153862997	0.14	Teddm1b	transmembrane epididymal protein 1B	11449	0.1
chr1_186684187_186684350	0.14	Gm26169	predicted gene, 26169	7526	0.16
chr12_103947943_103948118	0.14	Serpina1e	serine (or cysteine) peptidase inhibitor, clade A, member 1E	8868	0.11
chr6_87913437_87913823	0.14	Hmces	5-hydroxymethylcytosine (hmC) binding, ES cell specific	305	0.71
chr7_16405904_16406273	0.14	Gm45508	predicted gene 45508	1826	0.18
chr13_50047188_50047373	0.13	Gm48052	predicted gene, 48052	3725	0.16
chr3_18107731_18107882	0.13	Gm23726	predicted gene, 23726	38480	0.15
chr7_139416534_139416685	0.13	Inpp5a	inositol polyphosphate-5-phosphatase A	16120	0.23
chr11_102496845_102497026	0.13	Gm11628	predicted gene 11628	4326	0.12
chr14_27185973_27186174	0.13	Gm7591	predicted gene 7591	24324	0.18
chr15_79414701_79414859	0.13	Csnk1e	casein kinase 1, epsilon	6535	0.11
chr9_56938509_56938699	0.13	Imp3	IMP3, U3 small nucleolar ribonucleoprotein	1129	0.32
chr2_178606624_178606775	0.13	Cdh26	cadherin-like 26	146069	0.04
chr15_85868388_85868539	0.13	Gtse1	G two S phase expressed protein 1	8517	0.12
chr13_23307496_23307808	0.13	4930557F10Rik	RIKEN cDNA 4930557F10 gene	5748	0.09
chr8_72169355_72169641	0.13	Rab8a	RAB8A, member RAS oncogene family	8139	0.09
chr6_38120784_38120952	0.13	Gm23231	predicted gene, 23231	2485	0.22
chr10_117906642_117906793	0.13	4933411E08Rik	RIKEN cDNA 4933411E08 gene	18742	0.15
chr18_69537508_69537694	0.13	Gm24845	predicted gene, 24845	14362	0.23
chr2_27381428_27381611	0.13	Gm24049	predicted gene, 24049	20333	0.14
chr11_44546590_44546755	0.13	Rnf145	ring finger protein 145	10159	0.18
chr3_94398765_94399136	0.13	Lingo4	leucine rich repeat and Ig domain containing 4	433	0.59
chr2_58769522_58769673	0.13	Upp2	uridine phosphorylase 2	4272	0.24
chr3_21905574_21905725	0.13	Gm43674	predicted gene 43674	92819	0.08
chr12_52505478_52505629	0.13	Arhgap5	Rho GTPase activating protein 5	1211	0.47
chr5_20319781_20319982	0.13	Gm22755	predicted gene, 22755	55540	0.13
chr5_125490850_125491058	0.13	Gm27551	predicted gene, 27551	11577	0.13
chr17_26538205_26538356	0.12	Gm50275	predicted gene, 50275	53	0.95
chr6_90491129_90491426	0.12	Aldh1l1	aldehyde dehydrogenase 1 family, member L1	4850	0.12
chrX_75673853_75674412	0.12	Gm15065	predicted gene 15065	31277	0.13
chr1_67207883_67208119	0.12	Gm15668	predicted gene 15668	41199	0.15
chr9_118099534_118099709	0.12	Azi2	5-azacytidine induced gene 2	40565	0.13
chr10_79879613_79879900	0.12	Prtn3	proteinase 3	142	0.85
chr10_99169914_99170080	0.12	Poc1b	POC1 centriolar protein B	1287	0.35
chr13_9097997_9098273	0.12	Larp4b	La ribonucleoprotein domain family, member 4B	4153	0.18
chr12_112630609_112630843	0.12	Adssl1	adenylosuccinate synthetase like 1	8646	0.11
chr8_105235292_105235443	0.12	D230025D16Rik	RIKEN cDNA D230025D16 gene	4399	0.09
chr11_72472528_72472733	0.12	Spns2	spinster homolog 2	2397	0.21
chr9_107544674_107544842	0.12	Nprl2	NPR2 like, GATOR1 complex subunit	780	0.3
chr11_105974677_105975033	0.12	Ace	angiotensin I converting enzyme (peptidyl-dipeptidase A) 1	353	0.78
chr4_36131695_36131853	0.12	Lingo2	leucine rich repeat and Ig domain containing 2	4689	0.35
chr6_94050888_94051087	0.12	Magi1	membrane associated guanylate kinase, WW and PDZ domain containing 1	137297	0.05
chr6_38122561_38122726	0.12	Atp6v0a4	ATPase, H+ transporting, lysosomal V0 subunit A4	1846	0.28
chr4_63360320_63360510	0.12	Orm2	orosomucoid 2	2034	0.19
chr15_82362153_82362313	0.12	Ndufa6	NADH:ubiquinone oxidoreductase subunit A6	7911	0.07
chr2_59979696_59979870	0.12	Gm13574	predicted gene 13574	12561	0.19
chr4_35069175_35069344	0.12	Ifnk	interferon kappa	82797	0.07
chr16_43381191_43381342	0.12	Zbtb20	zinc finger and BTB domain containing 20	17062	0.17
chr16_24860524_24860695	0.12	Lpp	LIM domain containing preferred translocation partner in lipoma	15434	0.2
chr12_103311070_103311221	0.12	Fam181a	family with sequence similarity 181, member A	170	0.92
chr15_77548351_77548502	0.12	1700025B11Rik	RIKEN cDNA 1700025B11 gene	13466	0.11
chr3_137943821_137943983	0.12	Dapp1	dual adaptor for phosphotyrosine and 3-phosphoinositides 1	10811	0.1
chr14_11132816_11133186	0.12	Fhit	fragile histidine triad gene	7410	0.24
chr17_70990050_70990412	0.12	Myl12b	myosin, light chain 12B, regulatory	299	0.82
chr19_8128072_8128223	0.12	Slc22a28	solute carrier family 22, member 28	3835	0.25
chr1_67170641_67171204	0.12	Cps1	carbamoyl-phosphate synthetase 1	47896	0.14
chr14_121720285_121720661	0.12	Dock9	dedicator of cytokinesis 9	18388	0.23
chr6_96116339_96116711	0.12	Tafa1	TAFA chemokine like family member 1	1214	0.58
chr17_87379036_87379189	0.12	Ttc7	tetratricopeptide repeat domain 7	259	0.89
chr11_16819306_16819457	0.12	Egfros	epidermal growth factor receptor, opposite strand	11321	0.22
chr2_31745589_31745792	0.11	Abl1	c-abl oncogene 1, non-receptor tyrosine kinase	14253	0.14
chr18_21242831_21243130	0.11	Garem1	GRB2 associated regulator of MAPK1 subtype 1	57143	0.11
chr9_72720556_72720835	0.11	Gm37955	predicted gene, 37955	3735	0.13
chr7_38209598_38209825	0.11	D530033B14Rik	RIKEN cDNA D530033B14 gene	13254	0.12
chr14_7841370_7841604	0.11	Flnb	filamin, beta	23530	0.15
chr6_48493256_48493431	0.11	Sspo	SCO-spondin	437	0.68
chr11_120809505_120809952	0.11	Fasn	fatty acid synthase	27	0.95
chr6_90535262_90535425	0.11	Aldh1l1	aldehyde dehydrogenase 1 family, member L1	15446	0.12
chr4_101331247_101331398	0.11	Gm12796	predicted gene 12796	9577	0.1
chr10_95146574_95146766	0.11	Gm29684	predicted gene, 29684	845	0.56
chr9_103249018_103249229	0.11	1300017J02Rik	RIKEN cDNA 1300017J02 gene	7903	0.17
chr4_153019323_153019495	0.11	Gm25779	predicted gene, 25779	5825	0.32
chr8_35208499_35208650	0.11	Gm34474	predicted gene, 34474	10064	0.14
chr4_122872061_122872212	0.11	Cap1	CAP, adenylate cyclase-associated protein 1 (yeast)	7504	0.17
chr7_121043590_121043802	0.11	Gm27991	predicted gene, 27991	3216	0.11
chr17_34153027_34153195	0.11	H2-DMb1	histocompatibility 2, class II, locus Mb1	39	0.92
chr14_76149595_76149834	0.11	Nufip1	nuclear fragile X mental retardation protein interacting protein 1	38823	0.15
chr12_70991810_70992010	0.11	Psma3	proteasome subunit alpha 3	5018	0.16
chr9_53344725_53344910	0.11	Exph5	exophilin 5	3628	0.22
chr5_151103258_151103409	0.11	Stard13	StAR-related lipid transfer (START) domain containing 13	5402	0.28
chr4_108318788_108318978	0.11	Gm12740	predicted gene 12740	3455	0.16
chr6_39259262_39259413	0.11	Gm26008	predicted gene, 26008	6605	0.17
chr14_65722029_65722405	0.11	Scara5	scavenger receptor class A, member 5	45740	0.14
chr9_109123416_109123604	0.11	Plxnb1	plexin B1	16716	0.1
chr1_92903311_92903462	0.11	Ankmy1	ankyrin repeat and MYND domain containing 1	480	0.64
chr1_131990500_131990816	0.11	Slc45a3	solute carrier family 45, member 3	11694	0.12
chr1_67146866_67147049	0.11	Cps1	carbamoyl-phosphate synthetase 1	23931	0.21
chr14_120362393_120362544	0.11	Mbnl2	muscleblind like splicing factor 2	16773	0.22
chr5_30643999_30644150	0.11	Slc35f6	solute carrier family 35, member F6	3859	0.14
chr2_52579266_52579417	0.11	Cacnb4	calcium channel, voltage-dependent, beta 4 subunit	20774	0.18

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of Spdef

View svg image
View png image

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.2	GO:1903800	positive regulation of production of miRNAs involved in gene silencing by miRNA(GO:1903800)
0.1	0.2	GO:1902744	negative regulation of lamellipodium organization(GO:1902744)
0.1	0.2	GO:2001013	epithelial cell proliferation involved in renal tubule morphogenesis(GO:2001013)
0.0	0.1	GO:0006543	glutamine catabolic process(GO:0006543)
0.0	0.1	GO:0003062	regulation of heart rate by chemical signal(GO:0003062)
0.0	0.2	GO:0006526	arginine biosynthetic process(GO:0006526)
0.0	0.1	GO:0046121	deoxyribonucleoside catabolic process(GO:0046121)
0.0	0.1	GO:0097029	mature conventional dendritic cell differentiation(GO:0097029)
0.0	0.2	GO:1903799	negative regulation of production of miRNAs involved in gene silencing by miRNA(GO:1903799)
0.0	0.1	GO:0045218	zonula adherens maintenance(GO:0045218)
0.0	0.1	GO:0060800	regulation of cell differentiation involved in embryonic placenta development(GO:0060800)
0.0	0.1	GO:2000664	positive regulation of interleukin-5 secretion(GO:2000664) positive regulation of interleukin-13 secretion(GO:2000667)
0.0	0.1	GO:0034499	late endosome to Golgi transport(GO:0034499)
0.0	0.1	GO:0006549	isoleucine metabolic process(GO:0006549)
0.0	0.0	GO:0010424	DNA methylation on cytosine within a CG sequence(GO:0010424) DNA methylation on cytosine(GO:0032776)
0.0	0.1	GO:1903596	regulation of gap junction assembly(GO:1903596)
0.0	0.1	GO:0089700	protein kinase D signaling(GO:0089700)
0.0	0.1	GO:0030423	targeting of mRNA for destruction involved in RNA interference(GO:0030423)
0.0	0.1	GO:1903964	monounsaturated fatty acid metabolic process(GO:1903964) monounsaturated fatty acid biosynthetic process(GO:1903966)
0.0	0.0	GO:2000611	positive regulation of thyroid hormone generation(GO:2000611)
0.0	0.1	GO:0046499	S-adenosylmethioninamine metabolic process(GO:0046499)
0.0	0.1	GO:1903599	positive regulation of mitophagy(GO:1903599)
0.0	0.1	GO:0006562	proline catabolic process(GO:0006562)
0.0	0.1	GO:0015760	hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760)
0.0	0.1	GO:0003431	growth plate cartilage chondrocyte development(GO:0003431)
0.0	0.1	GO:1903059	regulation of protein lipidation(GO:1903059)
0.0	0.1	GO:0046069	cGMP catabolic process(GO:0046069)
0.0	0.1	GO:0002155	regulation of thyroid hormone mediated signaling pathway(GO:0002155)
0.0	0.1	GO:2000474	regulation of opioid receptor signaling pathway(GO:2000474)
0.0	0.0	GO:2000828	regulation of parathyroid hormone secretion(GO:2000828)
0.0	0.1	GO:0070072	vacuolar proton-transporting V-type ATPase complex assembly(GO:0070072)
0.0	0.0	GO:0044337	canonical Wnt signaling pathway involved in positive regulation of apoptotic process(GO:0044337)
0.0	0.1	GO:0021555	midbrain-hindbrain boundary morphogenesis(GO:0021555)
0.0	0.1	GO:0097460	ferrous iron import into cell(GO:0097460)
0.0	0.1	GO:0018317	protein C-linked glycosylation(GO:0018103) peptidyl-tryptophan modification(GO:0018211) protein C-linked glycosylation via tryptophan(GO:0018317) protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan(GO:0018406)
0.0	0.1	GO:0036462	TRAIL-activated apoptotic signaling pathway(GO:0036462)
0.0	0.0	GO:0006015	5-phosphoribose 1-diphosphate biosynthetic process(GO:0006015) 5-phosphoribose 1-diphosphate metabolic process(GO:0046391)
0.0	0.0	GO:0021699	cerebellar cortex maturation(GO:0021699)
0.0	0.1	GO:0008355	olfactory learning(GO:0008355)
0.0	0.4	GO:0019432	triglyceride biosynthetic process(GO:0019432)
0.0	0.0	GO:1904154	positive regulation of retrograde protein transport, ER to cytosol(GO:1904154)
0.0	0.0	GO:0006166	purine ribonucleoside salvage(GO:0006166)
0.0	0.0	GO:1903336	negative regulation of vacuolar transport(GO:1903336)
0.0	0.0	GO:0044336	canonical Wnt signaling pathway involved in negative regulation of apoptotic process(GO:0044336)
0.0	0.0	GO:0006382	adenosine to inosine editing(GO:0006382)
0.0	0.0	GO:0044004	killing by symbiont of host cells(GO:0001907) disruption by symbiont of host cell(GO:0044004)
0.0	0.0	GO:1902263	apoptotic process involved in embryonic digit morphogenesis(GO:1902263)
0.0	0.0	GO:0006068	ethanol catabolic process(GO:0006068)
0.0	0.1	GO:1990118	sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118)
0.0	0.5	GO:0006953	acute-phase response(GO:0006953)
0.0	0.1	GO:0010886	positive regulation of cholesterol storage(GO:0010886)
0.0	0.1	GO:0006337	nucleosome disassembly(GO:0006337) protein-DNA complex disassembly(GO:0032986)
0.0	0.0	GO:0006982	response to lipid hydroperoxide(GO:0006982)
0.0	0.1	GO:0051013	microtubule severing(GO:0051013)
0.0	0.1	GO:0051085	chaperone mediated protein folding requiring cofactor(GO:0051085)
0.0	0.0	GO:1902498	regulation of protein autoubiquitination(GO:1902498)
0.0	0.1	GO:0097084	vascular smooth muscle cell development(GO:0097084)
0.0	0.0	GO:0015770	disaccharide transport(GO:0015766) sucrose transport(GO:0015770) oligosaccharide transport(GO:0015772)
0.0	0.0	GO:0072361	regulation of glycolytic process by regulation of transcription from RNA polymerase II promoter(GO:0072361)
0.0	0.0	GO:0032058	positive regulation of translational initiation in response to stress(GO:0032058)
0.0	0.0	GO:0034755	iron ion transmembrane transport(GO:0034755)
0.0	0.1	GO:0060340	positive regulation of type I interferon-mediated signaling pathway(GO:0060340)
0.0	0.0	GO:0010901	regulation of very-low-density lipoprotein particle remodeling(GO:0010901)
0.0	0.0	GO:0097252	oligodendrocyte apoptotic process(GO:0097252)
0.0	0.1	GO:0003406	retinal pigment epithelium development(GO:0003406)
0.0	0.1	GO:0009256	10-formyltetrahydrofolate metabolic process(GO:0009256)
0.0	0.1	GO:1901339	regulation of store-operated calcium channel activity(GO:1901339)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.2	GO:0097487	multivesicular body, internal vesicle(GO:0097487)
0.0	0.1	GO:0031265	CD95 death-inducing signaling complex(GO:0031265)
0.0	0.2	GO:0042587	glycogen granule(GO:0042587)
0.0	0.1	GO:0045098	type III intermediate filament(GO:0045098)
0.0	0.0	GO:0034365	discoidal high-density lipoprotein particle(GO:0034365)
0.0	0.1	GO:0000220	vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220)
0.0	0.0	GO:0034363	intermediate-density lipoprotein particle(GO:0034363)
0.0	0.0	GO:0005945	6-phosphofructokinase complex(GO:0005945)
0.0	0.1	GO:0005915	zonula adherens(GO:0005915)
0.0	0.1	GO:0008250	oligosaccharyltransferase complex(GO:0008250)
0.0	0.1	GO:0031094	platelet dense tubular network(GO:0031094)
0.0	0.0	GO:0032299	ribonuclease H2 complex(GO:0032299)
0.0	0.1	GO:1990712	HFE-transferrin receptor complex(GO:1990712)
0.0	0.1	GO:0070578	RISC-loading complex(GO:0070578)
0.0	0.1	GO:0044326	dendritic spine neck(GO:0044326)
0.0	0.1	GO:0034362	low-density lipoprotein particle(GO:0034362)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.2	GO:0048408	epidermal growth factor binding(GO:0048408)
0.1	0.2	GO:0016743	carboxyl- or carbamoyltransferase activity(GO:0016743)
0.0	0.1	GO:0004359	glutaminase activity(GO:0004359)
0.0	0.1	GO:0008240	tripeptidyl-peptidase activity(GO:0008240)
0.0	0.1	GO:0035877	death effector domain binding(GO:0035877)
0.0	0.1	GO:0008184	glycogen phosphorylase activity(GO:0008184)
0.0	0.1	GO:0032896	palmitoyl-CoA 9-desaturase activity(GO:0032896)
0.0	0.1	GO:0030368	interleukin-17 receptor activity(GO:0030368)
0.0	0.2	GO:0004312	fatty acid synthase activity(GO:0004312)
0.0	0.1	GO:0003886	DNA (cytosine-5-)-methyltransferase activity(GO:0003886) DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates(GO:0051718)
0.0	0.1	GO:0016635	oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor(GO:0016635)
0.0	0.1	GO:0070097	delta-catenin binding(GO:0070097)
0.0	0.0	GO:0003872	6-phosphofructokinase activity(GO:0003872)
0.0	0.0	GO:0046976	histone methyltransferase activity (H3-K27 specific)(GO:0046976)
0.0	0.1	GO:0005168	neurotrophin TRKA receptor binding(GO:0005168)
0.0	0.0	GO:0015526	hexose phosphate transmembrane transporter activity(GO:0015119) organophosphate:inorganic phosphate antiporter activity(GO:0015315) hexose-phosphate:inorganic phosphate antiporter activity(GO:0015526) glucose 6-phosphate:inorganic phosphate antiporter activity(GO:0061513)
0.0	0.0	GO:0050309	glucose-6-phosphatase activity(GO:0004346) sugar-terminal-phosphatase activity(GO:0050309)
0.0	0.1	GO:0004045	aminoacyl-tRNA hydrolase activity(GO:0004045)
0.0	0.1	GO:0070883	pre-miRNA binding(GO:0070883)
0.0	0.0	GO:0032190	acrosin binding(GO:0032190)
0.0	0.0	GO:0032422	purine-rich negative regulatory element binding(GO:0032422)
0.0	0.2	GO:0016832	aldehyde-lyase activity(GO:0016832)
0.0	0.1	GO:0008199	ferric iron binding(GO:0008199)
0.0	0.1	GO:0008195	phosphatidate phosphatase activity(GO:0008195)
0.0	0.0	GO:0070653	high-density lipoprotein particle receptor binding(GO:0070653)
0.0	0.0	GO:0004366	glycerol-3-phosphate O-acyltransferase activity(GO:0004366)
0.0	0.3	GO:0003785	actin monomer binding(GO:0003785)
0.0	0.1	GO:0034056	estrogen response element binding(GO:0034056)
0.0	0.1	GO:0047760	butyrate-CoA ligase activity(GO:0047760)
0.0	0.0	GO:0035276	alcohol dehydrogenase activity, zinc-dependent(GO:0004024) ethanol binding(GO:0035276)
0.0	0.1	GO:0032036	myosin heavy chain binding(GO:0032036)
0.0	0.0	GO:0034714	type III transforming growth factor beta receptor binding(GO:0034714)
0.0	0.1	GO:0047555	3',5'-cyclic-GMP phosphodiesterase activity(GO:0047555)
0.0	0.0	GO:0008515	sucrose:proton symporter activity(GO:0008506) sucrose transmembrane transporter activity(GO:0008515) disaccharide transmembrane transporter activity(GO:0015154) oligosaccharide transmembrane transporter activity(GO:0015157)
0.0	0.1	GO:0015385	sodium:proton antiporter activity(GO:0015385) potassium:proton antiporter activity(GO:0015386)
0.0	0.0	GO:0047105	aminobutyraldehyde dehydrogenase activity(GO:0019145) 4-trimethylammoniobutyraldehyde dehydrogenase activity(GO:0047105)
0.0	0.0	GO:0004096	catalase activity(GO:0004096)
0.0	0.1	GO:0034785	3-(3-hydroxyphenyl)propionate hydroxylase activity(GO:0008688) 4-chlorobenzaldehyde oxidase activity(GO:0018471) 3,5-xylenol methylhydroxylase activity(GO:0018630) phenylacetate hydroxylase activity(GO:0018631) 4-nitrophenol 4-monooxygenase activity(GO:0018632) dimethyl sulfide monooxygenase activity(GO:0018633) alpha-pinene monooxygenase [NADH] activity(GO:0018634) 1-hydroxy-2-naphthoate hydroxylase activity(GO:0018637) toluene 4-monooxygenase activity(GO:0018638) xylene monooxygenase activity(GO:0018639) dibenzothiophene monooxygenase activity(GO:0018640) 6-hydroxy-3-methyl-2-oxo-1,2-dihydroquinoline 6-monooxygenase activity(GO:0018641) chlorophenol 4-monooxygenase activity(GO:0018642) carbon disulfide oxygenase activity(GO:0018643) toluene 2-monooxygenase activity(GO:0018644) 1-hydroxy-2-oxolimonene 1,2-monooxygenase activity(GO:0018646) phenanthrene 1,2-monooxygenase activity(GO:0018647) tetrahydrofuran hydroxylase activity(GO:0018649) styrene monooxygenase activity(GO:0018650) toluene-4-sulfonate monooxygenase activity(GO:0018651) toluene-sulfonate methyl-monooxygenase activity(GO:0018652) 3-methyl-2-oxo-1,2-dihydroquinoline 6-monooxygenase activity(GO:0018653) 2-hydroxy-phenylacetate hydroxylase activity(GO:0018654) 2-oxo-delta3-4,5,5-trimethylcyclopentenylacetyl-CoA 1,2-monooxygenase activity(GO:0018655) phenanthrene 3,4-monooxygenase activity(GO:0018656) toluene 3-monooxygenase activity(GO:0018657) 4-hydroxyphenylacetate,NADH:oxygen oxidoreductase (3-hydroxylating) activity(GO:0018660) limonene monooxygenase activity(GO:0019113) 2-methylnaphthalene hydroxylase activity(GO:0034526) 1-methylnaphthalene hydroxylase activity(GO:0034534) bisphenol A hydroxylase A activity(GO:0034560) salicylate 5-hydroxylase activity(GO:0034785) isobutylamine N-hydroxylase activity(GO:0034791) branched-chain dodecylbenzene sulfonate monooxygenase activity(GO:0034802) 3-HSA hydroxylase activity(GO:0034819) 4-hydroxypyridine-3-hydroxylase activity(GO:0034894) 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase activity(GO:0043719) 6-hydroxynicotinate 3-monooxygenase activity(GO:0043731) thalianol hydroxylase activity(GO:0080014)

Gene overrepresentation in curated gene sets: canonical pathways category:

Total log-likelihood	Term	Description
0.3	SA CASPASE CASCADE	Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.3	PID ECADHERIN KERATINOCYTE PATHWAY	E-cadherin signaling in keratinocytes
0.0	PID PDGFRA PATHWAY	PDGFR-alpha signaling pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Total log-likelihood	Term	Description
0.2	REACTOME VITAMIN B5 PANTOTHENATE METABOLISM	Genes involved in Vitamin B5 (pantothenate) metabolism
0.0	REACTOME REGULATION OF APOPTOSIS	Genes involved in Regulation of Apoptosis
0.1	REACTOME SYNTHESIS OF PE	Genes involved in Synthesis of PE
0.2	REACTOME SHC1 EVENTS IN EGFR SIGNALING	Genes involved in SHC1 events in EGFR signaling
0.1	REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS	Genes involved in Extrinsic Pathway for Apoptosis
0.1	REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK	Genes involved in Regulation of Rheb GTPase activity by AMPK
0.2	REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION	Genes involved in Amino acid synthesis and interconversion (transamination)