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ENCSR904DTN: DNase-seq of mouse liver in constant darkness
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Results for Spdef

Z-value: 1.07

Motif logo

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Transcription factors associated with Spdef

Gene Symbol Gene ID Gene Info
Spdef
ENSMUSG00000024215.7 SAM pointed domain containing ets transcription factor

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE Gene Distance Association probability Pearson corr. coef. P-value Plot
chr17_27716973_27717159Spdef6530.588600-0.891.7e-02Click!
chr17_27716769_27716920Spdef8750.465415-0.651.6e-01Click!
chr17_27721382_27721552Spdef31180.1604140.354.9e-01Click!
chr17_27717560_27717711Spdef840.952160-0.315.5e-01Click!

Activity of the Spdef motif across conditions

Conditions sorted by the z-value of the Spdef motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE) Target Score Top associated gene Gene Info Distance of CRE to TSS CRE/Gene association probability
chr7_97413837_97414007 0.55 Thrsp
 thyroid hormone responsive
 3597
 0.16
chr12_4220651_4220920 0.44 Gm48210
 predicted gene, 48210
 1317
 0.27
chr17_84226805_84226999 0.42 Thada
 thyroid adenoma associated
 2958
 0.24
chr16_45377470_45377621 0.37 Cd200
 CD200 antigen
 22767
 0.16
chr1_67134415_67135075 0.34 Cps1
 carbamoyl-phosphate synthetase 1
 11719
 0.24
chr11_16844975_16845160 0.33 Egfros
 epidermal growth factor receptor, opposite strand
 14365
 0.2
chr17_8797635_8797786 0.32 Pde10a
 phosphodiesterase 10A
 3983
 0.29
chr4_63355986_63356174 0.31 Orm3
 orosomucoid 3
 82
 0.95
chr14_28998848_28998999 0.30 Gm23999
 predicted gene, 23999
 10876
 0.19
chr6_88003582_88003770 0.30 4933412L11Rik
 RIKEN cDNA 4933412L11 gene
 9497
 0.09
chr14_52012195_52012346 0.29 Zfp219
 zinc finger protein 219
 1388
 0.21
chr5_43146388_43146587 0.29 Gm42552
 predicted gene 42552
 1840
 0.38
chr3_69280240_69280391 0.29 Ppm1l
 protein phosphatase 1 (formerly 2C)-like
 36546
 0.13
chr3_31970158_31970309 0.28 Gm37834
 predicted gene, 37834
 15469
 0.27
chr12_4220183_4220334 0.27 Gm48210
 predicted gene, 48210
 1844
 0.19
chr9_122849425_122849576 0.27 Gm47140
 predicted gene, 47140
 1082
 0.34
chr2_72741921_72742104 0.27 6430710C18Rik
 RIKEN cDNA 6430710C18 gene
 8841
 0.22
chr12_103991999_103992602 0.27 Serpina11
 serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 11
 2343
 0.16
chr5_50031875_50032113 0.26 Adgra3
 adhesion G protein-coupled receptor A3
 21385
 0.19
chr9_46092730_46092881 0.26 Sik3
 SIK family kinase 3
 30325
 0.14
chr16_43330685_43330836 0.25 Gm15711
 predicted gene 15711
 18166
 0.16
chr6_146751805_146751963 0.25 Gm44270
 predicted gene, 44270
 10697
 0.14
chr4_63350215_63350540 0.25 Gm11212
 predicted gene 11212
 34
 0.96
chr8_76148232_76148470 0.25 Gm45742
 predicted gene 45742
 31324
 0.21
chr7_35748679_35748830 0.25 Dpy19l3
 dpy-19-like 3 (C. elegans)
 5601
 0.2
chr19_11977402_11977711 0.25 Osbp
 oxysterol binding protein
 11615
 0.09
chr6_137773601_137773762 0.24 Dera
 deoxyribose-phosphate aldolase (putative)
 1308
 0.52
chr3_94702452_94702603 0.24 Selenbp2
 selenium binding protein 2
 8868
 0.11
chr10_40502877_40503043 0.22 Gm18671
 predicted gene, 18671
 45932
 0.12
chr6_38144404_38144577 0.22 D630045J12Rik
 RIKEN cDNA D630045J12 gene
 2884
 0.23
chr19_44399974_44400175 0.22 Scd1
 stearoyl-Coenzyme A desaturase 1
 6616
 0.15
chr5_125040097_125040498 0.22 Ncor2
 nuclear receptor co-repressor 2
 2515
 0.25
chr1_71735697_71735877 0.22 Gm5256
 predicted gene 5256
 20863
 0.17
chr3_97635501_97635936 0.21 Fmo5
 flavin containing monooxygenase 5
 6835
 0.14
chr1_88248965_88249116 0.21 Mroh2a
 maestro heat-like repeat family member 2A
 8718
 0.09
chr11_120810230_120810550 0.21 Fasn
 fatty acid synthase
 689
 0.48
chr16_43234125_43234650 0.21 Zbtb20
 zinc finger and BTB domain containing 20
 1493
 0.45
chr17_35254998_35255149 0.21 Mir8094
 microRNA 8094
 3784
 0.06
chr12_104088559_104088873 0.20 Serpina4-ps1
 serine (or cysteine) peptidase inhibitor, clade A, member 4, pseudogene 1
 8067
 0.1
chr11_119007787_119007988 0.19 Cbx2
 chromobox 2
 15075
 0.15
chr19_25422520_25422717 0.19 Kank1
 KN motif and ankyrin repeat domains 1
 379
 0.88
chr9_74228469_74228620 0.19 Wdr72
 WD repeat domain 72
 45590
 0.18
chr2_112595326_112595515 0.19 Gm44374
 predicted gene, 44374
 18610
 0.17
chr11_16791951_16792316 0.19 Egfros
 epidermal growth factor receptor, opposite strand
 38569
 0.14
chr13_101718863_101719071 0.19 Pik3r1
 phosphoinositide-3-kinase regulatory subunit 1
 16863
 0.2
chr5_122320103_122320299 0.19 Gm15842
 predicted gene 15842
 17779
 0.09
chr18_12692319_12692517 0.19 Ttc39c
 tetratricopeptide repeat domain 39C
 2690
 0.21
chr2_58761406_58761587 0.18 Upp2
 uridine phosphorylase 2
 3829
 0.24
chr4_154297797_154298168 0.18 Arhgef16
 Rho guanine nucleotide exchange factor (GEF) 16
 1910
 0.29
chr19_34270258_34270414 0.18 Gm50239
 predicted gene, 50239
 14201
 0.14
chr10_42708978_42709129 0.18 Gm15200
 predicted gene 15200
 10535
 0.18
chr7_123643560_123643752 0.18 Zkscan2
 zinc finger with KRAB and SCAN domains 2
 143207
 0.04
chr3_94705046_94705225 0.18 Selenbp2
 selenium binding protein 2
 11476
 0.11
chr2_58761173_58761336 0.18 Upp2
 uridine phosphorylase 2
 4071
 0.24
chr12_104740709_104740870 0.18 Dicer1
 dicer 1, ribonuclease type III
 1952
 0.38
chr17_28016505_28016679 0.18 Anks1
 ankyrin repeat and SAM domain containing 1
 9247
 0.12
chr11_60196823_60197490 0.18 Mir6921
 microRNA 6921
 3461
 0.14
chr6_24046716_24047018 0.17 Slc13a1
 solute carrier family 13 (sodium/sulfate symporters), member 1
 61704
 0.12
chr10_128206622_128206773 0.17 Gls2
 glutaminase 2 (liver, mitochondrial)
 228
 0.82
chr11_5906758_5906909 0.17 Gck
 glucokinase
 4746
 0.13
chr10_4731451_4731623 0.17 Esr1
 estrogen receptor 1 (alpha)
 18886
 0.26
chr11_60202909_60203232 0.17 Srebf1
 sterol regulatory element binding transcription factor 1
 418
 0.59
chr2_30144800_30144973 0.17 Tbc1d13
 TBC1 domain family, member 13
 2607
 0.15
chr9_121881807_121881992 0.17 Gm47113
 predicted gene, 47113
 12403
 0.08
chr3_21986159_21986455 0.17 Gm43674
 predicted gene 43674
 12161
 0.21
chr8_104831387_104831616 0.17 Ces2b
 carboxyesterase 2B
 71
 0.94
chr5_87562697_87562848 0.17 Sult1d1
 sulfotransferase family 1D, member 1
 2581
 0.17
chr7_72260804_72260982 0.17 Mctp2
 multiple C2 domains, transmembrane 2
 31533
 0.22
chr12_70720580_70720731 0.17 Gm32369
 predicted gene, 32369
 38805
 0.12
chr2_91750560_91750711 0.16 Ambra1
 autophagy/beclin 1 regulator 1
 15810
 0.14
chr11_60816993_60817396 0.16 Gm12611
 predicted gene 12611
 819
 0.38
chr19_44397890_44398071 0.16 Scd1
 stearoyl-Coenzyme A desaturase 1
 8710
 0.15
chr18_12711826_12711991 0.16 Mir1948
 microRNA 1948
 2903
 0.2
chr12_86826629_86826835 0.16 Gm10095
 predicted gene 10095
 19735
 0.17
chr9_21838672_21838867 0.16 Angptl8
 angiopoietin-like 8
 3259
 0.14
chr4_63348935_63349236 0.16 Gm11212
 predicted gene 11212
 1326
 0.29
chr2_181522503_181522654 0.16 Dnajc5
 DnaJ heat shock protein family (Hsp40) member C5
 1631
 0.22
chr10_58228380_58228585 0.16 Gm10807
 predicted gene 10807
 169
 0.92
chr10_99171877_99172060 0.16 Poc1b
 POC1 centriolar protein B
 684
 0.6
chr7_116183557_116183712 0.16 Plekha7
 pleckstrin homology domain containing, family A member 7
 881
 0.63
chr12_75448996_75449191 0.16 Gphb5
 glycoprotein hormone beta 5
 32312
 0.18
chr17_46073702_46073982 0.16 Gm36200
 predicted gene, 36200
 10424
 0.13
chr8_82255910_82256078 0.16 Gm38590
 predicted gene, 38590
 48459
 0.15
chr14_65615417_65615662 0.15 Nuggc
 nuclear GTPase, germinal center associated
 10272
 0.2
chr9_116185819_116186009 0.15 Gm4668
 predicted gene 4668
 3266
 0.22
chr4_152264194_152264355 0.15 Gpr153
 G protein-coupled receptor 153
 9958
 0.12
chr5_90468289_90468670 0.15 Alb
 albumin
 5779
 0.16
chr3_27704926_27705320 0.15 Fndc3b
 fibronectin type III domain containing 3B
 5275
 0.31
chr6_97962459_97962619 0.15 Mitf
 melanogenesis associated transcription factor
 21621
 0.24
chr13_23298661_23298830 0.15 Gm11333
 predicted gene 11333
 696
 0.46
chr10_114191151_114191309 0.15 Gm48104
 predicted gene, 48104
 95503
 0.09
chr4_32290238_32290389 0.15 Bach2it1
 BTB and CNC homology 2, intronic transcript 1
 38552
 0.16
chr13_108338110_108338518 0.15 Depdc1b
 DEP domain containing 1B
 11786
 0.18
chr4_45800098_45800462 0.15 Aldh1b1
 aldehyde dehydrogenase 1 family, member B1
 1159
 0.41
chr14_17768072_17768293 0.15 Gm48320
 predicted gene, 48320
 2940
 0.39
chr2_156722367_156722542 0.14 Dlgap4
 DLG associated protein 4
 962
 0.41
chr10_8230404_8230563 0.14 Gm30906
 predicted gene, 30906
 54352
 0.15
chr8_34164335_34164526 0.14 Mir6395
 microRNA 6395
 2282
 0.18
chr14_21181187_21181360 0.14 Adk
 adenosine kinase
 105121
 0.06
chr4_97885463_97885690 0.14 Nfia
 nuclear factor I/A
 5457
 0.31
chr6_28423868_28424057 0.14 Gcc1
 golgi coiled coil 1
 191
 0.56
chr7_28957656_28957827 0.14 Actn4
 actinin alpha 4
 4482
 0.12
chr8_84723903_84724146 0.14 G430095P16Rik
 RIKEN cDNA G430095P16 gene
 1017
 0.36
chr11_16880492_16880986 0.14 Egfr
 epidermal growth factor receptor
 2589
 0.29
chr9_120133572_120133723 0.14 Gm5922
 predicted gene 5922
 1368
 0.2
chr7_106236793_106236971 0.14 Gvin1
 GTPase, very large interferon inducible 1
 21556
 0.16
chr4_72398261_72398417 0.14 Gm11235
 predicted gene 11235
 144327
 0.05
chr11_16816779_16816940 0.14 Egfros
 epidermal growth factor receptor, opposite strand
 13843
 0.21
chr17_43242727_43242878 0.14 Adgrf1
 adhesion G protein-coupled receptor F1
 27527
 0.22
chr17_86552135_86552300 0.14 Gm10309
 predicted gene 10309
 46985
 0.15
chr1_153862795_153862997 0.14 Teddm1b
 transmembrane epididymal protein 1B
 11449
 0.1
chr1_186684187_186684350 0.14 Gm26169
 predicted gene, 26169
 7526
 0.16
chr12_103947943_103948118 0.14 Serpina1e
 serine (or cysteine) peptidase inhibitor, clade A, member 1E
 8868
 0.11
chr6_87913437_87913823 0.14 Hmces
 5-hydroxymethylcytosine (hmC) binding, ES cell specific
 305
 0.71
chr7_16405904_16406273 0.14 Gm45508
 predicted gene 45508
 1826
 0.18
chr13_50047188_50047373 0.13 Gm48052
 predicted gene, 48052
 3725
 0.16
chr3_18107731_18107882 0.13 Gm23726
 predicted gene, 23726
 38480
 0.15
chr7_139416534_139416685 0.13 Inpp5a
 inositol polyphosphate-5-phosphatase A
 16120
 0.23
chr11_102496845_102497026 0.13 Gm11628
 predicted gene 11628
 4326
 0.12
chr14_27185973_27186174 0.13 Gm7591
 predicted gene 7591
 24324
 0.18
chr15_79414701_79414859 0.13 Csnk1e
 casein kinase 1, epsilon
 6535
 0.11
chr9_56938509_56938699 0.13 Imp3
 IMP3, U3 small nucleolar ribonucleoprotein
 1129
 0.32
chr2_178606624_178606775 0.13 Cdh26
 cadherin-like 26
 146069
 0.04
chr15_85868388_85868539 0.13 Gtse1
 G two S phase expressed protein 1
 8517
 0.12
chr13_23307496_23307808 0.13 4930557F10Rik
 RIKEN cDNA 4930557F10 gene
 5748
 0.09
chr8_72169355_72169641 0.13 Rab8a
 RAB8A, member RAS oncogene family
 8139
 0.09
chr6_38120784_38120952 0.13 Gm23231
 predicted gene, 23231
 2485
 0.22
chr10_117906642_117906793 0.13 4933411E08Rik
 RIKEN cDNA 4933411E08 gene
 18742
 0.15
chr18_69537508_69537694 0.13 Gm24845
 predicted gene, 24845
 14362
 0.23
chr2_27381428_27381611 0.13 Gm24049
 predicted gene, 24049
 20333
 0.14
chr11_44546590_44546755 0.13 Rnf145
 ring finger protein 145
 10159
 0.18
chr3_94398765_94399136 0.13 Lingo4
 leucine rich repeat and Ig domain containing 4
 433
 0.59
chr2_58769522_58769673 0.13 Upp2
 uridine phosphorylase 2
 4272
 0.24
chr3_21905574_21905725 0.13 Gm43674
 predicted gene 43674
 92819
 0.08
chr12_52505478_52505629 0.13 Arhgap5
 Rho GTPase activating protein 5
 1211
 0.47
chr5_20319781_20319982 0.13 Gm22755
 predicted gene, 22755
 55540
 0.13
chr5_125490850_125491058 0.13 Gm27551
 predicted gene, 27551
 11577
 0.13
chr17_26538205_26538356 0.12 Gm50275
 predicted gene, 50275
 53
 0.95
chr6_90491129_90491426 0.12 Aldh1l1
 aldehyde dehydrogenase 1 family, member L1
 4850
 0.12
chrX_75673853_75674412 0.12 Gm15065
 predicted gene 15065
 31277
 0.13
chr1_67207883_67208119 0.12 Gm15668
 predicted gene 15668
 41199
 0.15
chr9_118099534_118099709 0.12 Azi2
 5-azacytidine induced gene 2
 40565
 0.13
chr10_79879613_79879900 0.12 Prtn3
 proteinase 3
 142
 0.85
chr10_99169914_99170080 0.12 Poc1b
 POC1 centriolar protein B
 1287
 0.35
chr13_9097997_9098273 0.12 Larp4b
 La ribonucleoprotein domain family, member 4B
 4153
 0.18
chr12_112630609_112630843 0.12 Adssl1
 adenylosuccinate synthetase like 1
 8646
 0.11
chr8_105235292_105235443 0.12 D230025D16Rik
 RIKEN cDNA D230025D16 gene
 4399
 0.09
chr11_72472528_72472733 0.12 Spns2
 spinster homolog 2
 2397
 0.21
chr9_107544674_107544842 0.12 Nprl2
 NPR2 like, GATOR1 complex subunit
 780
 0.3
chr11_105974677_105975033 0.12 Ace
 angiotensin I converting enzyme (peptidyl-dipeptidase A) 1
 353
 0.78
chr4_36131695_36131853 0.12 Lingo2
 leucine rich repeat and Ig domain containing 2
 4689
 0.35
chr6_94050888_94051087 0.12 Magi1
 membrane associated guanylate kinase, WW and PDZ domain containing 1
 137297
 0.05
chr6_38122561_38122726 0.12 Atp6v0a4
 ATPase, H+ transporting, lysosomal V0 subunit A4
 1846
 0.28
chr4_63360320_63360510 0.12 Orm2
 orosomucoid 2
 2034
 0.19
chr15_82362153_82362313 0.12 Ndufa6
 NADH:ubiquinone oxidoreductase subunit A6
 7911
 0.07
chr2_59979696_59979870 0.12 Gm13574
 predicted gene 13574
 12561
 0.19
chr4_35069175_35069344 0.12 Ifnk
 interferon kappa
 82797
 0.07
chr16_43381191_43381342 0.12 Zbtb20
 zinc finger and BTB domain containing 20
 17062
 0.17
chr16_24860524_24860695 0.12 Lpp
 LIM domain containing preferred translocation partner in lipoma
 15434
 0.2
chr12_103311070_103311221 0.12 Fam181a
 family with sequence similarity 181, member A
 170
 0.92
chr15_77548351_77548502 0.12 1700025B11Rik
 RIKEN cDNA 1700025B11 gene
 13466
 0.11
chr3_137943821_137943983 0.12 Dapp1
 dual adaptor for phosphotyrosine and 3-phosphoinositides 1
 10811
 0.1
chr14_11132816_11133186 0.12 Fhit
 fragile histidine triad gene
 7410
 0.24
chr17_70990050_70990412 0.12 Myl12b
 myosin, light chain 12B, regulatory
 299
 0.82
chr19_8128072_8128223 0.12 Slc22a28
 solute carrier family 22, member 28
 3835
 0.25
chr1_67170641_67171204 0.12 Cps1
 carbamoyl-phosphate synthetase 1
 47896
 0.14
chr14_121720285_121720661 0.12 Dock9
 dedicator of cytokinesis 9
 18388
 0.23
chr6_96116339_96116711 0.12 Tafa1
 TAFA chemokine like family member 1
 1214
 0.58
chr17_87379036_87379189 0.12 Ttc7
 tetratricopeptide repeat domain 7
 259
 0.89
chr11_16819306_16819457 0.12 Egfros
 epidermal growth factor receptor, opposite strand
 11321
 0.22
chr2_31745589_31745792 0.11 Abl1
 c-abl oncogene 1, non-receptor tyrosine kinase
 14253
 0.14
chr18_21242831_21243130 0.11 Garem1
 GRB2 associated regulator of MAPK1 subtype 1
 57143
 0.11
chr9_72720556_72720835 0.11 Gm37955
 predicted gene, 37955
 3735
 0.13
chr7_38209598_38209825 0.11 D530033B14Rik
 RIKEN cDNA D530033B14 gene
 13254
 0.12
chr14_7841370_7841604 0.11 Flnb
 filamin, beta
 23530
 0.15
chr6_48493256_48493431 0.11 Sspo
 SCO-spondin
 437
 0.68
chr11_120809505_120809952 0.11 Fasn
 fatty acid synthase
 27
 0.95
chr6_90535262_90535425 0.11 Aldh1l1
 aldehyde dehydrogenase 1 family, member L1
 15446
 0.12
chr4_101331247_101331398 0.11 Gm12796
 predicted gene 12796
 9577
 0.1
chr10_95146574_95146766 0.11 Gm29684
 predicted gene, 29684
 845
 0.56
chr9_103249018_103249229 0.11 1300017J02Rik
 RIKEN cDNA 1300017J02 gene
 7903
 0.17
chr4_153019323_153019495 0.11 Gm25779
 predicted gene, 25779
 5825
 0.32
chr8_35208499_35208650 0.11 Gm34474
 predicted gene, 34474
 10064
 0.14
chr4_122872061_122872212 0.11 Cap1
 CAP, adenylate cyclase-associated protein 1 (yeast)
 7504
 0.17
chr7_121043590_121043802 0.11 Gm27991
 predicted gene, 27991
 3216
 0.11
chr17_34153027_34153195 0.11 H2-DMb1
 histocompatibility 2, class II, locus Mb1
 39
 0.92
chr14_76149595_76149834 0.11 Nufip1
 nuclear fragile X mental retardation protein interacting protein 1
 38823
 0.15
chr12_70991810_70992010 0.11 Psma3
 proteasome subunit alpha 3
 5018
 0.16
chr9_53344725_53344910 0.11 Exph5
 exophilin 5
 3628
 0.22
chr5_151103258_151103409 0.11 Stard13
 StAR-related lipid transfer (START) domain containing 13
 5402
 0.28
chr4_108318788_108318978 0.11 Gm12740
 predicted gene 12740
 3455
 0.16
chr6_39259262_39259413 0.11 Gm26008
 predicted gene, 26008
 6605
 0.17
chr14_65722029_65722405 0.11 Scara5
 scavenger receptor class A, member 5
 45740
 0.14
chr9_109123416_109123604 0.11 Plxnb1
 plexin B1
 16716
 0.1
chr1_92903311_92903462 0.11 Ankmy1
 ankyrin repeat and MYND domain containing 1
 480
 0.64
chr1_131990500_131990816 0.11 Slc45a3
 solute carrier family 45, member 3
 11694
 0.12
chr1_67146866_67147049 0.11 Cps1
 carbamoyl-phosphate synthetase 1
 23931
 0.21
chr14_120362393_120362544 0.11 Mbnl2
 muscleblind like splicing factor 2
 16773
 0.22
chr5_30643999_30644150 0.11 Slc35f6
 solute carrier family 35, member F6
 3859
 0.14
chr2_52579266_52579417 0.11 Cacnb4
 calcium channel, voltage-dependent, beta 4 subunit
 20774
 0.18

Histogram of CRE-TSS distances for CREs targeted by :

Histogram of

Rank distribution of CRE target scores:

Histogram of target CRE score.

Distribution of target CREs across different genomic regions:

Weighted Piechart of Weighted Piechart of Weighted Piechart of

Network of associatons between targets according to the STRING database.

First level regulatory network of Spdef

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:1903800 positive regulation of production of miRNAs involved in gene silencing by miRNA(GO:1903800)
0.1 0.2 GO:1902744 negative regulation of lamellipodium organization(GO:1902744)
0.1 0.2 GO:2001013 epithelial cell proliferation involved in renal tubule morphogenesis(GO:2001013)
0.0 0.1 GO:0006543 glutamine catabolic process(GO:0006543)
0.0 0.1 GO:0003062 regulation of heart rate by chemical signal(GO:0003062)
0.0 0.2 GO:0006526 arginine biosynthetic process(GO:0006526)
0.0 0.1 GO:0046121 deoxyribonucleoside catabolic process(GO:0046121)
0.0 0.1 GO:0097029 mature conventional dendritic cell differentiation(GO:0097029)
0.0 0.2 GO:1903799 negative regulation of production of miRNAs involved in gene silencing by miRNA(GO:1903799)
0.0 0.1 GO:0045218 zonula adherens maintenance(GO:0045218)
0.0 0.1 GO:0060800 regulation of cell differentiation involved in embryonic placenta development(GO:0060800)
0.0 0.1 GO:2000664 positive regulation of interleukin-5 secretion(GO:2000664) positive regulation of interleukin-13 secretion(GO:2000667)
0.0 0.1 GO:0034499 late endosome to Golgi transport(GO:0034499)
0.0 0.1 GO:0006549 isoleucine metabolic process(GO:0006549)
0.0 0.0 GO:0010424 DNA methylation on cytosine within a CG sequence(GO:0010424) DNA methylation on cytosine(GO:0032776)
0.0 0.1 GO:1903596 regulation of gap junction assembly(GO:1903596)
0.0 0.1 GO:0089700 protein kinase D signaling(GO:0089700)
0.0 0.1 GO:0030423 targeting of mRNA for destruction involved in RNA interference(GO:0030423)
0.0 0.1 GO:1903964 monounsaturated fatty acid metabolic process(GO:1903964) monounsaturated fatty acid biosynthetic process(GO:1903966)
0.0 0.0 GO:2000611 positive regulation of thyroid hormone generation(GO:2000611)
0.0 0.1 GO:0046499 S-adenosylmethioninamine metabolic process(GO:0046499)
0.0 0.1 GO:1903599 positive regulation of mitophagy(GO:1903599)
0.0 0.1 GO:0006562 proline catabolic process(GO:0006562)
0.0 0.1 GO:0015760 hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760)
0.0 0.1 GO:0003431 growth plate cartilage chondrocyte development(GO:0003431)
0.0 0.1 GO:1903059 regulation of protein lipidation(GO:1903059)
0.0 0.1 GO:0046069 cGMP catabolic process(GO:0046069)
0.0 0.1 GO:0002155 regulation of thyroid hormone mediated signaling pathway(GO:0002155)
0.0 0.1 GO:2000474 regulation of opioid receptor signaling pathway(GO:2000474)
0.0 0.0 GO:2000828 regulation of parathyroid hormone secretion(GO:2000828)
0.0 0.1 GO:0070072 vacuolar proton-transporting V-type ATPase complex assembly(GO:0070072)
0.0 0.0 GO:0044337 canonical Wnt signaling pathway involved in positive regulation of apoptotic process(GO:0044337)
0.0 0.1 GO:0021555 midbrain-hindbrain boundary morphogenesis(GO:0021555)
0.0 0.1 GO:0097460 ferrous iron import into cell(GO:0097460)
0.0 0.1 GO:0018317 protein C-linked glycosylation(GO:0018103) peptidyl-tryptophan modification(GO:0018211) protein C-linked glycosylation via tryptophan(GO:0018317) protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan(GO:0018406)
0.0 0.1 GO:0036462 TRAIL-activated apoptotic signaling pathway(GO:0036462)
0.0 0.0 GO:0006015 5-phosphoribose 1-diphosphate biosynthetic process(GO:0006015) 5-phosphoribose 1-diphosphate metabolic process(GO:0046391)
0.0 0.0 GO:0021699 cerebellar cortex maturation(GO:0021699)
0.0 0.1 GO:0008355 olfactory learning(GO:0008355)
0.0 0.4 GO:0019432 triglyceride biosynthetic process(GO:0019432)
0.0 0.0 GO:1904154 positive regulation of retrograde protein transport, ER to cytosol(GO:1904154)
0.0 0.0 GO:0006166 purine ribonucleoside salvage(GO:0006166)
0.0 0.0 GO:1903336 negative regulation of vacuolar transport(GO:1903336)
0.0 0.0 GO:0044336 canonical Wnt signaling pathway involved in negative regulation of apoptotic process(GO:0044336)
0.0 0.0 GO:0006382 adenosine to inosine editing(GO:0006382)
0.0 0.0 GO:0044004 killing by symbiont of host cells(GO:0001907) disruption by symbiont of host cell(GO:0044004)
0.0 0.0 GO:1902263 apoptotic process involved in embryonic digit morphogenesis(GO:1902263)
0.0 0.0 GO:0006068 ethanol catabolic process(GO:0006068)
0.0 0.1 GO:1990118 sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118)
0.0 0.5 GO:0006953 acute-phase response(GO:0006953)
0.0 0.1 GO:0010886 positive regulation of cholesterol storage(GO:0010886)
0.0 0.1 GO:0006337 nucleosome disassembly(GO:0006337) protein-DNA complex disassembly(GO:0032986)
0.0 0.0 GO:0006982 response to lipid hydroperoxide(GO:0006982)
0.0 0.1 GO:0051013 microtubule severing(GO:0051013)
0.0 0.1 GO:0051085 chaperone mediated protein folding requiring cofactor(GO:0051085)
0.0 0.0 GO:1902498 regulation of protein autoubiquitination(GO:1902498)
0.0 0.1 GO:0097084 vascular smooth muscle cell development(GO:0097084)
0.0 0.0 GO:0015770 disaccharide transport(GO:0015766) sucrose transport(GO:0015770) oligosaccharide transport(GO:0015772)
0.0 0.0 GO:0072361 regulation of glycolytic process by regulation of transcription from RNA polymerase II promoter(GO:0072361)
0.0 0.0 GO:0032058 positive regulation of translational initiation in response to stress(GO:0032058)
0.0 0.0 GO:0034755 iron ion transmembrane transport(GO:0034755)
0.0 0.1 GO:0060340 positive regulation of type I interferon-mediated signaling pathway(GO:0060340)
0.0 0.0 GO:0010901 regulation of very-low-density lipoprotein particle remodeling(GO:0010901)
0.0 0.0 GO:0097252 oligodendrocyte apoptotic process(GO:0097252)
0.0 0.1 GO:0003406 retinal pigment epithelium development(GO:0003406)
0.0 0.1 GO:0009256 10-formyltetrahydrofolate metabolic process(GO:0009256)
0.0 0.1 GO:1901339 regulation of store-operated calcium channel activity(GO:1901339)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0097487 multivesicular body, internal vesicle(GO:0097487)
0.0 0.1 GO:0031265 CD95 death-inducing signaling complex(GO:0031265)
0.0 0.2 GO:0042587 glycogen granule(GO:0042587)
0.0 0.1 GO:0045098 type III intermediate filament(GO:0045098)
0.0 0.0 GO:0034365 discoidal high-density lipoprotein particle(GO:0034365)
0.0 0.1 GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220)
0.0 0.0 GO:0034363 intermediate-density lipoprotein particle(GO:0034363)
0.0 0.0 GO:0005945 6-phosphofructokinase complex(GO:0005945)
0.0 0.1 GO:0005915 zonula adherens(GO:0005915)
0.0 0.1 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.0 0.1 GO:0031094 platelet dense tubular network(GO:0031094)
0.0 0.0 GO:0032299 ribonuclease H2 complex(GO:0032299)
0.0 0.1 GO:1990712 HFE-transferrin receptor complex(GO:1990712)
0.0 0.1 GO:0070578 RISC-loading complex(GO:0070578)
0.0 0.1 GO:0044326 dendritic spine neck(GO:0044326)
0.0 0.1 GO:0034362 low-density lipoprotein particle(GO:0034362)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0048408 epidermal growth factor binding(GO:0048408)
0.1 0.2 GO:0016743 carboxyl- or carbamoyltransferase activity(GO:0016743)
0.0 0.1 GO:0004359 glutaminase activity(GO:0004359)
0.0 0.1 GO:0008240 tripeptidyl-peptidase activity(GO:0008240)
0.0 0.1 GO:0035877 death effector domain binding(GO:0035877)
0.0 0.1 GO:0008184 glycogen phosphorylase activity(GO:0008184)
0.0 0.1 GO:0032896 palmitoyl-CoA 9-desaturase activity(GO:0032896)
0.0 0.1 GO:0030368 interleukin-17 receptor activity(GO:0030368)
0.0 0.2 GO:0004312 fatty acid synthase activity(GO:0004312)
0.0 0.1 GO:0003886 DNA (cytosine-5-)-methyltransferase activity(GO:0003886) DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates(GO:0051718)
0.0 0.1 GO:0016635 oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor(GO:0016635)
0.0 0.1 GO:0070097 delta-catenin binding(GO:0070097)
0.0 0.0 GO:0003872 6-phosphofructokinase activity(GO:0003872)
0.0 0.0 GO:0046976 histone methyltransferase activity (H3-K27 specific)(GO:0046976)
0.0 0.1 GO:0005168 neurotrophin TRKA receptor binding(GO:0005168)
0.0 0.0 GO:0015526 hexose phosphate transmembrane transporter activity(GO:0015119) organophosphate:inorganic phosphate antiporter activity(GO:0015315) hexose-phosphate:inorganic phosphate antiporter activity(GO:0015526) glucose 6-phosphate:inorganic phosphate antiporter activity(GO:0061513)
0.0 0.0 GO:0050309 glucose-6-phosphatase activity(GO:0004346) sugar-terminal-phosphatase activity(GO:0050309)
0.0 0.1 GO:0004045 aminoacyl-tRNA hydrolase activity(GO:0004045)
0.0 0.1 GO:0070883 pre-miRNA binding(GO:0070883)
0.0 0.0 GO:0032190 acrosin binding(GO:0032190)
0.0 0.0 GO:0032422 purine-rich negative regulatory element binding(GO:0032422)
0.0 0.2 GO:0016832 aldehyde-lyase activity(GO:0016832)
0.0 0.1 GO:0008199 ferric iron binding(GO:0008199)
0.0 0.1 GO:0008195 phosphatidate phosphatase activity(GO:0008195)
0.0 0.0 GO:0070653 high-density lipoprotein particle receptor binding(GO:0070653)
0.0 0.0 GO:0004366 glycerol-3-phosphate O-acyltransferase activity(GO:0004366)
0.0 0.3 GO:0003785 actin monomer binding(GO:0003785)
0.0 0.1 GO:0034056 estrogen response element binding(GO:0034056)
0.0 0.1 GO:0047760 butyrate-CoA ligase activity(GO:0047760)
0.0 0.0 GO:0035276 alcohol dehydrogenase activity, zinc-dependent(GO:0004024) ethanol binding(GO:0035276)
0.0 0.1 GO:0032036 myosin heavy chain binding(GO:0032036)
0.0 0.0 GO:0034714 type III transforming growth factor beta receptor binding(GO:0034714)
0.0 0.1 GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity(GO:0047555)
0.0 0.0 GO:0008515 sucrose:proton symporter activity(GO:0008506) sucrose transmembrane transporter activity(GO:0008515) disaccharide transmembrane transporter activity(GO:0015154) oligosaccharide transmembrane transporter activity(GO:0015157)
0.0 0.1 GO:0015385 sodium:proton antiporter activity(GO:0015385) potassium:proton antiporter activity(GO:0015386)
0.0 0.0 GO:0047105 aminobutyraldehyde dehydrogenase activity(GO:0019145) 4-trimethylammoniobutyraldehyde dehydrogenase activity(GO:0047105)
0.0 0.0 GO:0004096 catalase activity(GO:0004096)
0.0 0.1 GO:0034785 3-(3-hydroxyphenyl)propionate hydroxylase activity(GO:0008688) 4-chlorobenzaldehyde oxidase activity(GO:0018471) 3,5-xylenol methylhydroxylase activity(GO:0018630) phenylacetate hydroxylase activity(GO:0018631) 4-nitrophenol 4-monooxygenase activity(GO:0018632) dimethyl sulfide monooxygenase activity(GO:0018633) alpha-pinene monooxygenase [NADH] activity(GO:0018634) 1-hydroxy-2-naphthoate hydroxylase activity(GO:0018637) toluene 4-monooxygenase activity(GO:0018638) xylene monooxygenase activity(GO:0018639) dibenzothiophene monooxygenase activity(GO:0018640) 6-hydroxy-3-methyl-2-oxo-1,2-dihydroquinoline 6-monooxygenase activity(GO:0018641) chlorophenol 4-monooxygenase activity(GO:0018642) carbon disulfide oxygenase activity(GO:0018643) toluene 2-monooxygenase activity(GO:0018644) 1-hydroxy-2-oxolimonene 1,2-monooxygenase activity(GO:0018646) phenanthrene 1,2-monooxygenase activity(GO:0018647) tetrahydrofuran hydroxylase activity(GO:0018649) styrene monooxygenase activity(GO:0018650) toluene-4-sulfonate monooxygenase activity(GO:0018651) toluene-sulfonate methyl-monooxygenase activity(GO:0018652) 3-methyl-2-oxo-1,2-dihydroquinoline 6-monooxygenase activity(GO:0018653) 2-hydroxy-phenylacetate hydroxylase activity(GO:0018654) 2-oxo-delta3-4,5,5-trimethylcyclopentenylacetyl-CoA 1,2-monooxygenase activity(GO:0018655) phenanthrene 3,4-monooxygenase activity(GO:0018656) toluene 3-monooxygenase activity(GO:0018657) 4-hydroxyphenylacetate,NADH:oxygen oxidoreductase (3-hydroxylating) activity(GO:0018660) limonene monooxygenase activity(GO:0019113) 2-methylnaphthalene hydroxylase activity(GO:0034526) 1-methylnaphthalene hydroxylase activity(GO:0034534) bisphenol A hydroxylase A activity(GO:0034560) salicylate 5-hydroxylase activity(GO:0034785) isobutylamine N-hydroxylase activity(GO:0034791) branched-chain dodecylbenzene sulfonate monooxygenase activity(GO:0034802) 3-HSA hydroxylase activity(GO:0034819) 4-hydroxypyridine-3-hydroxylase activity(GO:0034894) 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase activity(GO:0043719) 6-hydroxynicotinate 3-monooxygenase activity(GO:0043731) thalianol hydroxylase activity(GO:0080014)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 SA CASPASE CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.0 0.3 PID ECADHERIN KERATINOCYTE PATHWAY E-cadherin signaling in keratinocytes
0.0 0.0 PID PDGFRA PATHWAY PDGFR-alpha signaling pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 REACTOME VITAMIN B5 PANTOTHENATE METABOLISM Genes involved in Vitamin B5 (pantothenate) metabolism
0.0 0.0 REACTOME REGULATION OF APOPTOSIS Genes involved in Regulation of Apoptosis
0.0 0.1 REACTOME SYNTHESIS OF PE Genes involved in Synthesis of PE
0.0 0.2 REACTOME SHC1 EVENTS IN EGFR SIGNALING Genes involved in SHC1 events in EGFR signaling
0.0 0.1 REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
0.0 0.1 REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK Genes involved in Regulation of Rheb GTPase activity by AMPK
0.0 0.2 REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)