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ENCSR904DTN: DNase-seq of mouse liver in constant darkness

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for Tbx15

Z-value: 0.39

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Transcription factors associated with Tbx15

Gene Symbol	Gene ID	Gene Info
Tbx15 Ensembl NCBI MGI UniProt	ENSMUSG00000027868.5	Tbx15

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

Gene	Promoter	Distance	Association probability	Pearson corr. coef.	P-value	Plot
Tbx15	chr3_99234096_99234265	6201	0.153550	-0.89	1.8e-02	Click!

Activity of the Tbx15 motif across conditions

Conditions sorted by the z-value of the Tbx15 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr1_52388262_52388419	0.55	Gm23460	predicted gene, 23460	56204	0.11
chr4_141316341_141316787	0.49	Epha2	Eph receptor A2	349	0.78
chr4_128946455_128946665	0.44	Gm15904	predicted gene 15904	10555	0.15
chr5_53437072_53437250	0.42	Gm26486	predicted gene, 26486	18588	0.17
chr11_59640294_59640451	0.36	Mprip	myosin phosphatase Rho interacting protein	20933	0.11
chr7_100658121_100658314	0.36	Plekhb1	pleckstrin homology domain containing, family B (evectins) member 1	147	0.93
chr4_11861132_11861344	0.35	Gm25002	predicted gene, 25002	87649	0.07
chr5_145993052_145993431	0.35	Cyp3a25	cytochrome P450, family 3, subfamily a, polypeptide 25	1598	0.28
chr14_65832955_65833117	0.34	Esco2	establishment of sister chromatid cohesion N-acetyltransferase 2	872	0.57
chr12_24463539_24463734	0.33	Gm16372	predicted pseudogene 16372	30020	0.14
chr8_122174579_122174745	0.33	Zfp469	zinc finger protein 469	83958	0.07
chr2_26405907_26406058	0.32	Inpp5e	inositol polyphosphate-5-phosphatase E	3145	0.11
chr5_75046920_75047087	0.32	Gm18593	predicted gene, 18593	1476	0.27
chr13_104615047_104615206	0.31	2610204G07Rik	RIKEN cDNA 2610204G07 gene	69805	0.12
chr11_107226116_107226397	0.30	Gm11718	predicted gene 11718	35162	0.12
chr10_78320688_78320839	0.29	Agpat3	1-acylglycerol-3-phosphate O-acyltransferase 3	73	0.94
chr1_93135074_93135362	0.28	Agxt	alanine-glyoxylate aminotransferase	22	0.96
chr12_80832436_80832620	0.28	Susd6	sushi domain containing 6	36180	0.11
chr4_117116805_117116956	0.27	Ptch2	patched 2	3456	0.09
chr4_134060274_134060433	0.27	Crybg2	crystallin beta-gamma domain containing 2	462	0.7
chr5_119295643_119295794	0.26	n-R5s175	nuclear encoded rRNA 5S 175	1527	0.52
chr5_117275916_117276216	0.26	Pebp1	phosphatidylethanolamine binding protein 1	11459	0.11
chr5_125296722_125296910	0.26	Scarb1	scavenger receptor class B, member 1	2707	0.22
chr14_20319722_20320198	0.26	Nudt13	nudix (nucleoside diphosphate linked moiety X)-type motif 13	8531	0.12
chr12_21526957_21527150	0.26	Gm19196	predicted gene, 19196	16254	0.22
chr7_104307089_104307261	0.26	Trim12a	tripartite motif-containing 12A	6141	0.08
chr8_119416779_119416930	0.26	Osgin1	oxidative stress induced growth inhibitor 1	17270	0.13
chr9_43225133_43225294	0.25	Oaf	out at first homolog	121	0.95
chr2_126776033_126776199	0.25	Usp50	ubiquitin specific peptidase 50	5660	0.18
chr7_104279565_104279731	0.25	Trim5	tripartite motif-containing 5	84	0.93
chr6_56919800_56919965	0.25	Nt5c3	5'-nucleotidase, cytosolic III	3842	0.15
chr5_8157542_8157699	0.25	Gm21759	predicted gene, 21759	22016	0.16
chr5_25019324_25019486	0.24	Prkag2	protein kinase, AMP-activated, gamma 2 non-catalytic subunit	23652	0.16
chr12_82914756_82914931	0.24	1700085C21Rik	RIKEN cDNA 1700085C21 gene	24312	0.21
chr8_121201174_121201325	0.24	5033426O07Rik	RIKEN cDNA 5033426O07 gene	586	0.75
chr13_80896624_80897028	0.24	Arrdc3	arrestin domain containing 3	6308	0.17
chr17_80468453_80468787	0.24	Sos1	SOS Ras/Rac guanine nucleotide exchange factor 1	11349	0.21
chr1_184093517_184093672	0.24	Dusp10	dual specificity phosphatase 10	59213	0.13
chr2_181373148_181373303	0.23	Zgpat	zinc finger, CCCH-type with G patch domain	5169	0.1
chr17_29093649_29093812	0.23	Cdkn1a	cyclin-dependent kinase inhibitor 1A (P21)	39	0.91
chr1_182661161_182661312	0.23	Gm37516	predicted gene, 37516	18703	0.17
chr8_120495609_120495777	0.22	Gse1	genetic suppressor element 1, coiled-coil protein	7246	0.15
chr11_86932862_86933027	0.22	Ypel2	yippee like 2	39080	0.14
chr1_180757970_180758155	0.22	Gm37768	predicted gene, 37768	2226	0.19
chr10_61337817_61337968	0.22	Pald1	phosphatase domain containing, paladin 1	4435	0.15
chrX_150956676_150956837	0.22	Gm8424	predicted gene 8424	30597	0.13
chr5_89416345_89416742	0.22	Gc	vitamin D binding protein	19085	0.24
chr8_120244102_120244267	0.21	Gse1	genetic suppressor element 1, coiled-coil protein	15728	0.17
chr5_138076351_138076506	0.21	Zkscan1	zinc finger with KRAB and SCAN domains 1	8656	0.09
chr6_86636895_86637046	0.21	Asprv1	aspartic peptidase, retroviral-like 1	8806	0.11
chr3_98311224_98311375	0.21	Phgdh	3-phosphoglycerate dehydrogenase	17314	0.14
chr11_101372782_101373038	0.20	G6pc	glucose-6-phosphatase, catalytic	5349	0.06
chr4_41637175_41637517	0.20	Gm12406	predicted gene 12406	2032	0.17
chr14_55079684_55079867	0.20	Zfhx2	zinc finger homeobox 2	677	0.47
chr14_30906842_30907058	0.20	Itih3	inter-alpha trypsin inhibitor, heavy chain 3	7179	0.11
chr1_133073713_133073881	0.20	Pik3c2b	phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta	5218	0.16
chr2_29437237_29437388	0.20	Gm24976	predicted gene, 24976	21882	0.15
chr2_3771544_3771776	0.20	Fam107b	family with sequence similarity 107, member B	952	0.57
chr3_83996881_83997402	0.20	Tmem131l	transmembrane 131 like	28913	0.2
chr1_132299853_132300009	0.20	Klhdc8a	kelch domain containing 8A	1305	0.31
chr19_23066702_23066853	0.19	Gm50136	predicted gene, 50136	5304	0.21
chr13_94708250_94708413	0.19	Gm32351	predicted gene, 32351	5613	0.17
chr15_34510659_34511041	0.19	Pop1	processing of precursor 1, ribonuclease P/MRP family, (S. cerevisiae)	943	0.43
chr7_72306635_72306827	0.19	Mctp2	multiple C2 domains, transmembrane 2	123	0.98
chr11_116209384_116209702	0.19	Ten1	TEN1 telomerase capping complex subunit	1391	0.24
chr14_74853189_74853575	0.19	Lrch1	leucine-rich repeats and calponin homology (CH) domain containing 1	31873	0.18
chr10_71183397_71183774	0.19	C730027H18Rik	RIKEN cDNA C730027H18 gene	1533	0.26
chr5_117997853_117998004	0.19	Fbxo21	F-box protein 21	18604	0.13
chr3_95652051_95652202	0.19	Mcl1	myeloid cell leukemia sequence 1	6662	0.1
chr3_27905130_27905320	0.19	Tmem212	transmembrane protein 212	8857	0.22
chr13_44302017_44302180	0.19	Gm29676	predicted gene, 29676	21649	0.18
chr6_89213939_89214095	0.19	Gm839	predicted gene 839	2220	0.22
chr10_61480037_61480223	0.19	D830039M14Rik	RIKEN cDNA D830039M14 gene	3193	0.13
chr1_155112239_155112390	0.19	Ier5	immediate early response 5	12678	0.14
chr15_25663250_25663426	0.19	Myo10	myosin X	11172	0.18
chr13_91765048_91765525	0.19	Gm27656	predicted gene, 27656	13180	0.14
chr5_136965885_136966036	0.18	Cldn15	claudin 15	656	0.49
chr12_84203864_84204015	0.18	Gm31513	predicted gene, 31513	7970	0.11
chr19_3687091_3687242	0.18	Lrp5	low density lipoprotein receptor-related protein 5	602	0.61
chr19_3329840_3329991	0.18	Cpt1a	carnitine palmitoyltransferase 1a, liver	3810	0.15
chr10_30810298_30810917	0.18	Ncoa7	nuclear receptor coactivator 7	7281	0.16
chr19_7456855_7457030	0.18	Rtn3	reticulon 3	26260	0.1
chr8_103538740_103538926	0.18	Gm45277	predicted gene 45277	24790	0.23
chr5_135139962_135140114	0.18	Mlxipl	MLX interacting protein-like	6407	0.11
chr4_116695063_116695819	0.18	Prdx1	peroxiredoxin 1	8129	0.1
chr10_28178649_28178847	0.18	Gm22370	predicted gene, 22370	35373	0.21
chr8_10857032_10857204	0.18	Gm32540	predicted gene, 32540	9068	0.12
chr5_66041014_66041178	0.18	Rbm47	RNA binding motif protein 47	13456	0.12
chr5_139197343_139197508	0.17	Sun1	Sad1 and UNC84 domain containing 1	3212	0.18
chr17_86754051_86754206	0.17	Epas1	endothelial PAS domain protein 1	428	0.83
chr5_134983246_134983642	0.17	Cldn3	claudin 3	2770	0.11
chr1_184875101_184875316	0.17	C130074G19Rik	RIKEN cDNA C130074G19 gene	8010	0.17
chr9_60926310_60926619	0.17	Gm47923	predicted gene, 47923	7241	0.21
chr10_25621100_25621500	0.17	Gm36908	predicted gene, 36908	263	0.92
chr18_6208229_6208380	0.17	Gm17036	predicted gene 17036	5609	0.19
chr11_117872061_117872251	0.17	Tha1	threonine aldolase 1	245	0.79
chr8_128465325_128465813	0.16	Nrp1	neuropilin 1	106172	0.06
chr1_106309746_106309897	0.16	Phlpp1	PH domain and leucine rich repeat protein phosphatase 1	7417	0.25
chr2_128174660_128174970	0.16	Gm14009	predicted gene 14009	15172	0.2
chr11_79230285_79230459	0.16	Wsb1	WD repeat and SOCS box-containing 1	12577	0.16
chr5_107837254_107837906	0.16	Evi5	ecotropic viral integration site 5	100	0.94
chr14_51105673_51105825	0.16	Eddm3b	epididymal protein 3B	8677	0.08
chr13_64361503_64361746	0.16	Gm49230	predicted gene, 49230	113	0.86
chr7_118244089_118244267	0.16	4930583K01Rik	RIKEN cDNA 4930583K01 gene	313	0.63
chr9_43737905_43738092	0.16	Gm30015	predicted gene, 30015	1043	0.39
chr17_56615160_56615323	0.16	Rpl36	ribosomal protein L36	1825	0.19
chr3_37902815_37902966	0.16	Gm20755	predicted gene, 20755	4077	0.21
chr14_118124260_118124415	0.16	Tgds	TDP-glucose 4,6-dehydratase	8407	0.18
chr19_40499284_40499488	0.16	Sorbs1	sorbin and SH3 domain containing 1	11640	0.19
chr1_167365951_167366119	0.16	Aldh9a1	aldehyde dehydrogenase 9, subfamily A1	1869	0.25
chr1_191822042_191822193	0.16	Nek2	NIMA (never in mitosis gene a)-related expressed kinase 2	65	0.58
chr6_134614784_134614949	0.16	Gm38910	predicted gene, 38910	7185	0.14
chr2_30363854_30364005	0.16	Miga2	mitoguardin 2	304	0.79
chr6_71203783_71204000	0.16	Fabp1	fatty acid binding protein 1, liver	4064	0.15
chrX_73466714_73466865	0.16	Haus7	HAUS augmin-like complex, subunit 7	7745	0.12
chr11_50199089_50199272	0.16	Sqstm1	sequestosome 1	3774	0.13
chr3_85813449_85813618	0.16	Fam160a1	family with sequence similarity 160, member A1	3758	0.23
chr2_168207294_168207658	0.15	Adnp	activity-dependent neuroprotective protein	364	0.77
chr2_72866286_72866437	0.15	6430710C18Rik	RIKEN cDNA 6430710C18 gene	52644	0.12
chr4_8755441_8755604	0.15	Chd7	chromodomain helicase DNA binding protein 7	4084	0.33
chr10_79855965_79856127	0.15	Ptbp1	polypyrimidine tract binding protein 1	1008	0.2
chr10_7832157_7832704	0.15	Zc3h12d	zinc finger CCCH type containing 12D	40	0.96
chr11_103011230_103011391	0.15	Dcakd	dephospho-CoA kinase domain containing	5858	0.13
chr9_91193419_91193605	0.15	Gm29602	predicted gene 29602	22503	0.17
chr1_155888091_155888242	0.15	Cep350	centrosomal protein 350	2152	0.22
chr7_84135967_84136134	0.15	Abhd17c	abhydrolase domain containing 17C	11765	0.15
chr4_99201116_99201393	0.15	Atg4c	autophagy related 4C, cysteine peptidase	7107	0.19
chr5_143412330_143412481	0.15	Kdelr2	KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2	8567	0.08
chr8_70680106_70680375	0.15	Lsm4	LSM4 homolog, U6 small nuclear RNA and mRNA degradation associated	2575	0.12
chr10_120977866_120978049	0.15	Lemd3	LEM domain containing 3	1375	0.33
chr3_98297519_98297734	0.15	Gm43189	predicted gene 43189	10638	0.14
chr15_75996647_75996807	0.15	Mapk15	mitogen-activated protein kinase 15	14	0.94
chr8_91379183_91379600	0.15	Fto	fat mass and obesity associated	11164	0.15
chr1_58475799_58475950	0.15	Orc2	origin recognition complex, subunit 2	5575	0.13
chr17_80483283_80483457	0.15	Sos1	SOS Ras/Rac guanine nucleotide exchange factor 1	2917	0.29
chr4_115815775_115815933	0.15	Mob3c	MOB kinase activator 3C	12238	0.12
chr2_105901718_105901869	0.14	Elp4	elongator acetyltransferase complex subunit 4	2690	0.24
chr4_116708269_116708638	0.14	Mmachc	methylmalonic aciduria cblC type, with homocystinuria	47	0.5
chr4_107159322_107159488	0.14	Tceanc2	transcription elongation factor A (SII) N-terminal and central domain containing 2	18263	0.12
chr5_102599017_102599403	0.14	1700013M08Rik	RIKEN cDNA 1700013M08 gene	115921	0.06
chr5_66139803_66139965	0.14	Rbm47	RNA binding motif protein 47	11072	0.11
chr11_53420114_53420567	0.14	Leap2	liver-expressed antimicrobial peptide 2	2830	0.12
chr5_124092063_124092447	0.14	Abcb9	ATP-binding cassette, sub-family B (MDR/TAP), member 9	1993	0.19
chr11_79670395_79670546	0.14	Rab11fip4os2	RAB11 family interacting protein 4 (class II), opposite strand 2	4613	0.13
chr1_181010068_181010284	0.14	Ephx1	epoxide hydrolase 1, microsomal	7393	0.09
chr14_47296314_47296470	0.14	Mapk1ip1l	mitogen-activated protein kinase 1 interacting protein 1-like	1874	0.15
chr9_24378970_24379135	0.14	Gm22380	predicted gene, 22380	27934	0.15
chr15_102181335_102181499	0.14	Csad	cysteine sulfinic acid decarboxylase	1556	0.24
chr19_4149325_4149619	0.14	Coro1b	coronin, actin binding protein 1B	805	0.28
chr5_112281749_112281914	0.14	Tpst2	protein-tyrosine sulfotransferase 2	5124	0.13
chr11_106581287_106581448	0.14	Tex2	testis expressed gene 2	767	0.66
chr13_32824374_32824659	0.14	Wrnip1	Werner helicase interacting protein 1	3750	0.17
chr9_63613110_63613389	0.14	Aagab	alpha- and gamma-adaptin binding protein	3739	0.23
chr1_171454993_171455144	0.14	F11r	F11 receptor	7782	0.1
chr8_75103139_75103449	0.14	Mcm5	minichromosome maintenance complex component 5	6275	0.14
chr10_19976391_19976640	0.13	Map3k5	mitogen-activated protein kinase kinase kinase 5	25460	0.2
chr7_112187666_112187837	0.13	Dkk3	dickkopf WNT signaling pathway inhibitor 3	28694	0.2
chr7_110840147_110840515	0.13	Rnf141	ring finger protein 141	2802	0.22
chr14_57259417_57259587	0.13	Gm8996	predicted gene 8996	42269	0.13
chr6_58879817_58880006	0.13	Herc3	hect domain and RLD 3	5568	0.21
chr1_45922514_45922876	0.13	Slc40a1	solute carrier family 40 (iron-regulated transporter), member 1	614	0.65
chr3_85974604_85974787	0.13	Sh3d19	SH3 domain protein D19	3586	0.14
chr7_48892680_48892953	0.13	Gm2788	predicted gene 2788	5586	0.14
chr6_15893625_15894040	0.13	Gm43990	predicted gene, 43990	57743	0.15
chr11_118265609_118265912	0.13	Usp36	ubiquitin specific peptidase 36	288	0.89
chr2_31558979_31559141	0.13	Gm13426	predicted gene 13426	6365	0.15
chr7_80360672_80360826	0.13	Man2a2	mannosidase 2, alpha 2	838	0.42
chr11_109500636_109500796	0.13	Gm22378	predicted gene, 22378	892	0.5
chr1_82239925_82240111	0.13	Gm9747	predicted gene 9747	6906	0.23
chr8_119417171_119417322	0.13	Osgin1	oxidative stress induced growth inhibitor 1	16878	0.13
chr6_146473719_146473882	0.13	Gm15720	predicted gene 15720	10193	0.19
chr5_114435733_114435884	0.13	Mmab	methylmalonic aciduria (cobalamin deficiency) cblB type homolog (human)	8184	0.14
chr7_19228690_19228852	0.13	Opa3	optic atrophy 3	388	0.68
chr1_74304286_74304581	0.13	Tmbim1	transmembrane BAX inhibitor motif containing 1	28	0.94
chr3_115815549_115815774	0.13	Dph5	diphthamide biosynthesis 5	72176	0.07
chr10_83032672_83032849	0.13	Gm10773	predicted gene 10773	1065	0.55
chr11_109488275_109488451	0.13	Arsg	arylsulfatase G	2757	0.18
chr8_41545072_41545241	0.13	Gapdh-ps14	glyceraldehyde-3-phosphate dehydrogenase, pseudogene 14	64513	0.13
chr7_99694133_99694291	0.13	Gm34280	predicted gene, 34280	85	0.93
chr10_121486376_121486686	0.13	Gm40787	predicted gene, 40787	2455	0.18
chr8_13037092_13037395	0.13	F10	coagulation factor X	65	0.94
chr12_8676206_8676575	0.13	Pum2	pumilio RNA-binding family member 2	1144	0.56
chr3_100201640_100202182	0.13	Gdap2	ganglioside-induced differentiation-associated-protein 2	1224	0.52
chr8_46837465_46837662	0.13	Gm45481	predicted gene 45481	3651	0.22
chr5_136526310_136526483	0.13	Gm38082	predicted gene, 38082	10081	0.22
chr8_94172420_94173095	0.13	Mt2	metallothionein 2	93	0.88
chr13_58123386_58123686	0.13	Hnrnpa0	heterogeneous nuclear ribonucleoprotein A0	5020	0.14
chr5_145743023_145743196	0.13	Gm43626	predicted gene 43626	17436	0.15
chr1_58097131_58097333	0.13	Aox3	aldehyde oxidase 3	15898	0.18
chr6_113434799_113434964	0.13	Cidec	cell death-inducing DFFA-like effector c	117	0.9
chr8_72222949_72223319	0.12	Fam32a	family with sequence similarity 32, member A	3370	0.12
chr11_21398793_21399367	0.12	Ugp2	UDP-glucose pyrophosphorylase 2	27879	0.12
chr18_31938569_31938916	0.12	Lims2	LIM and senescent cell antigen like domains 2	676	0.61
chr3_95643397_95643587	0.12	E330034L11Rik	RIKEN cDNA E330034L11 gene	4188	0.11
chr13_47179143_47179300	0.12	Rnf144b	ring finger protein 144B	14604	0.15
chr8_25840737_25841255	0.12	Ash2l	ASH2 like histone lysine methyltransferase complex subunit	209	0.91
chr16_30051044_30051883	0.12	9030404E10Rik	RIKEN cDNA 9030404E10 gene	11984	0.14
chr19_43971247_43971535	0.12	Cpn1	carboxypeptidase N, polypeptide 1	2698	0.21
chr1_134344955_134345133	0.12	Tmem183a	transmembrane protein 183A	5261	0.14
chr11_55468108_55468290	0.12	G3bp1	GTPase activating protein (SH3 domain) binding protein 1	1486	0.25

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of Tbx15

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:0046439	cysteine catabolic process(GO:0009093) L-cysteine catabolic process(GO:0019448) L-cysteine metabolic process(GO:0046439)
0.1	0.2	GO:0048320	axial mesoderm formation(GO:0048320)
0.1	0.2	GO:0034421	post-translational protein acetylation(GO:0034421)
0.1	0.2	GO:0006566	threonine metabolic process(GO:0006566)
0.0	0.2	GO:1904395	regulation of skeletal muscle acetylcholine-gated channel clustering(GO:1904393) positive regulation of skeletal muscle acetylcholine-gated channel clustering(GO:1904395)
0.0	0.1	GO:0071879	positive regulation of adrenergic receptor signaling pathway(GO:0071879)
0.0	0.1	GO:0034395	regulation of transcription from RNA polymerase II promoter in response to iron(GO:0034395)
0.0	0.1	GO:2000504	positive regulation of blood vessel remodeling(GO:2000504)
0.0	0.1	GO:0071725	response to triacyl bacterial lipopeptide(GO:0071725) cellular response to triacyl bacterial lipopeptide(GO:0071727)
0.0	0.1	GO:0010986	positive regulation of lipoprotein particle clearance(GO:0010986)
0.0	0.1	GO:0032474	otolith morphogenesis(GO:0032474)
0.0	0.1	GO:0021555	midbrain-hindbrain boundary morphogenesis(GO:0021555)
0.0	0.1	GO:0060397	JAK-STAT cascade involved in growth hormone signaling pathway(GO:0060397)
0.0	0.1	GO:0035461	vitamin transmembrane transport(GO:0035461)
0.0	0.1	GO:0010835	regulation of protein ADP-ribosylation(GO:0010835)
0.0	0.1	GO:0048625	myoblast fate commitment(GO:0048625)
0.0	0.1	GO:0032417	positive regulation of sodium:proton antiporter activity(GO:0032417)
0.0	0.1	GO:0071672	negative regulation of smooth muscle cell chemotaxis(GO:0071672)
0.0	0.1	GO:0030997	regulation of centriole-centriole cohesion(GO:0030997)
0.0	0.1	GO:2000483	negative regulation of interleukin-8 secretion(GO:2000483)
0.0	0.1	GO:0007296	vitellogenesis(GO:0007296)
0.0	0.2	GO:0043983	histone H4-K12 acetylation(GO:0043983)
0.0	0.1	GO:0060486	Clara cell differentiation(GO:0060486)
0.0	0.1	GO:0010273	detoxification of copper ion(GO:0010273) stress response to copper ion(GO:1990169)
0.0	0.0	GO:0045472	response to ether(GO:0045472)
0.0	0.1	GO:0070327	thyroid hormone transport(GO:0070327)
0.0	0.2	GO:0071493	cellular response to UV-B(GO:0071493)
0.0	0.1	GO:0061624	fructose catabolic process(GO:0006001) fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate(GO:0061624) glycolytic process through fructose-1-phosphate(GO:0061625)
0.0	0.1	GO:0046499	S-adenosylmethioninamine metabolic process(GO:0046499)
0.0	0.1	GO:0070318	positive regulation of G0 to G1 transition(GO:0070318)
0.0	0.1	GO:1903223	positive regulation of oxidative stress-induced neuron death(GO:1903223)
0.0	0.1	GO:0015712	hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760)
0.0	0.1	GO:0051365	cellular response to potassium ion starvation(GO:0051365)
0.0	0.1	GO:0009235	cobalamin metabolic process(GO:0009235)
0.0	0.1	GO:0006931	substrate-dependent cell migration, cell attachment to substrate(GO:0006931)
0.0	0.0	GO:0097296	activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:0097296)
0.0	0.1	GO:0006172	ADP biosynthetic process(GO:0006172)
0.0	0.2	GO:0061158	3'-UTR-mediated mRNA destabilization(GO:0061158)
0.0	0.1	GO:0015722	canalicular bile acid transport(GO:0015722)
0.0	0.1	GO:0030382	sperm mitochondrion organization(GO:0030382)
0.0	0.1	GO:0090038	negative regulation of protein kinase C signaling(GO:0090038)
0.0	0.1	GO:0032201	telomere maintenance via semi-conservative replication(GO:0032201) mitotic telomere maintenance via semi-conservative replication(GO:1902990)
0.0	0.1	GO:0038161	prolactin signaling pathway(GO:0038161)
0.0	0.1	GO:1902267	polyamine transmembrane transport(GO:1902047) regulation of polyamine transmembrane transport(GO:1902267)
0.0	0.1	GO:0009449	gamma-aminobutyric acid biosynthetic process(GO:0009449)
0.0	0.1	GO:0034316	negative regulation of Arp2/3 complex-mediated actin nucleation(GO:0034316)
0.0	0.1	GO:0090292	nuclear matrix organization(GO:0043578) nuclear matrix anchoring at nuclear membrane(GO:0090292)
0.0	0.1	GO:0071922	establishment of sister chromatid cohesion(GO:0034085) cohesin loading(GO:0071921) regulation of cohesin loading(GO:0071922)
0.0	0.1	GO:0052330	induction of programmed cell death(GO:0012502) positive regulation of apoptotic process in other organism(GO:0044533) positive regulation by symbiont of host programmed cell death(GO:0052042) positive regulation by symbiont of host apoptotic process(GO:0052151) positive regulation by organism of programmed cell death in other organism involved in symbiotic interaction(GO:0052330) positive regulation by organism of apoptotic process in other organism involved in symbiotic interaction(GO:0052501) positive regulation of apoptotic process by virus(GO:0060139)
0.0	0.1	GO:0006297	nucleotide-excision repair, DNA gap filling(GO:0006297)
0.0	0.1	GO:0045541	negative regulation of cholesterol biosynthetic process(GO:0045541) negative regulation of cholesterol metabolic process(GO:0090206)
0.0	0.0	GO:0002414	immunoglobulin transcytosis in epithelial cells(GO:0002414)
0.0	0.0	GO:2000346	negative regulation of hepatocyte proliferation(GO:2000346)
0.0	0.1	GO:0086073	bundle of His cell-Purkinje myocyte adhesion involved in cell communication(GO:0086073)
0.0	0.0	GO:0032439	endosome localization(GO:0032439)
0.0	0.1	GO:0090286	cytoskeletal anchoring at nuclear membrane(GO:0090286)
0.0	0.0	GO:0060051	negative regulation of protein glycosylation(GO:0060051)
0.0	0.0	GO:0045048	protein insertion into ER membrane(GO:0045048) tail-anchored membrane protein insertion into ER membrane(GO:0071816)
0.0	0.1	GO:0050847	progesterone receptor signaling pathway(GO:0050847)
0.0	0.1	GO:0048096	chromatin-mediated maintenance of transcription(GO:0048096)
0.0	0.0	GO:0003164	His-Purkinje system development(GO:0003164) bundle of His development(GO:0003166)
0.0	0.0	GO:0016554	cytidine to uridine editing(GO:0016554)
0.0	0.1	GO:0009115	xanthine catabolic process(GO:0009115)
0.0	0.0	GO:0002378	immunoglobulin biosynthetic process(GO:0002378)
0.0	0.0	GO:0035022	positive regulation of Rac protein signal transduction(GO:0035022)
0.0	0.0	GO:0006419	alanyl-tRNA aminoacylation(GO:0006419)
0.0	0.1	GO:0001561	fatty acid alpha-oxidation(GO:0001561)
0.0	0.0	GO:2000823	regulation of androgen receptor activity(GO:2000823)
0.0	0.0	GO:0045963	negative regulation of catecholamine metabolic process(GO:0045914) negative regulation of dopamine metabolic process(GO:0045963)
0.0	0.0	GO:0010728	regulation of hydrogen peroxide biosynthetic process(GO:0010728)
0.0	0.1	GO:0009437	carnitine metabolic process(GO:0009437)
0.0	0.0	GO:0001555	oocyte growth(GO:0001555)
0.0	0.0	GO:1902075	cellular response to salt(GO:1902075)
0.0	0.0	GO:0021914	negative regulation of smoothened signaling pathway involved in ventral spinal cord patterning(GO:0021914)
0.0	0.0	GO:0010735	positive regulation of transcription via serum response element binding(GO:0010735)
0.0	0.0	GO:0009448	gamma-aminobutyric acid metabolic process(GO:0009448)
0.0	0.1	GO:0060263	regulation of respiratory burst(GO:0060263)
0.0	0.1	GO:0055015	ventricular cardiac muscle cell development(GO:0055015)
0.0	0.0	GO:0090168	Golgi reassembly(GO:0090168)
0.0	0.2	GO:1904355	positive regulation of telomere capping(GO:1904355)
0.0	0.0	GO:0060137	maternal process involved in parturition(GO:0060137)
0.0	0.0	GO:0006556	S-adenosylmethionine biosynthetic process(GO:0006556)
0.0	0.0	GO:1902263	apoptotic process involved in embryonic digit morphogenesis(GO:1902263)
0.0	0.0	GO:0036091	positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress(GO:0036091)
0.0	0.1	GO:0006548	histidine catabolic process(GO:0006548) imidazole-containing compound catabolic process(GO:0052805)
0.0	0.1	GO:0061635	regulation of protein complex stability(GO:0061635)
0.0	0.0	GO:0006681	galactosylceramide metabolic process(GO:0006681)
0.0	0.1	GO:0070314	G1 to G0 transition(GO:0070314)
0.0	0.2	GO:0034389	lipid particle organization(GO:0034389)
0.0	0.0	GO:2001206	positive regulation of osteoclast development(GO:2001206)
0.0	0.0	GO:0045041	protein import into mitochondrial intermembrane space(GO:0045041)
0.0	0.1	GO:0006528	asparagine metabolic process(GO:0006528)
0.0	0.0	GO:0009298	GDP-mannose biosynthetic process(GO:0009298)
0.0	0.0	GO:0071726	response to diacyl bacterial lipopeptide(GO:0071724) cellular response to diacyl bacterial lipopeptide(GO:0071726)
0.0	0.1	GO:0042904	9-cis-retinoic acid biosynthetic process(GO:0042904) 9-cis-retinoic acid metabolic process(GO:0042905)
0.0	0.0	GO:1904833	positive regulation of superoxide dismutase activity(GO:1901671) positive regulation of removal of superoxide radicals(GO:1904833)
0.0	0.0	GO:0032898	neurotrophin production(GO:0032898)
0.0	0.1	GO:0051549	regulation of keratinocyte migration(GO:0051547) positive regulation of keratinocyte migration(GO:0051549)
0.0	0.0	GO:0046951	ketone body biosynthetic process(GO:0046951)
0.0	0.1	GO:0006013	mannose metabolic process(GO:0006013)

Gene overrepresentation in cellular component category:

Total log-likelihood	Term	Description
0.2	GO:0031618	nuclear pericentric heterochromatin(GO:0031618)
0.3	GO:1990462	omegasome(GO:1990462)
0.1	GO:0000172	ribonuclease MRP complex(GO:0000172)
0.2	GO:0000138	Golgi trans cisterna(GO:0000138)
0.1	GO:0061574	ASAP complex(GO:0061574)
0.1	GO:0002193	MAML1-RBP-Jkappa- ICN1 complex(GO:0002193)
0.1	GO:0046696	lipopolysaccharide receptor complex(GO:0046696)
0.4	GO:0005782	peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.1	GO:0005899	insulin receptor complex(GO:0005899)
0.1	GO:0044666	MLL3/4 complex(GO:0044666)
0.1	GO:0030868	smooth endoplasmic reticulum membrane(GO:0030868) smooth endoplasmic reticulum part(GO:0097425)
0.1	GO:0034992	microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.0	GO:0071818	BAT3 complex(GO:0071818) ER membrane insertion complex(GO:0072379)
0.1	GO:0005638	lamin filament(GO:0005638)
0.1	GO:0005577	fibrinogen complex(GO:0005577)
0.1	GO:0000815	ESCRT III complex(GO:0000815)
0.0	GO:0042583	chromaffin granule(GO:0042583)
0.0	GO:0097136	Bcl-2 family protein complex(GO:0097136)
0.1	GO:0033588	Elongator holoenzyme complex(GO:0033588)
0.1	GO:0031083	BLOC-1 complex(GO:0031083)
0.0	GO:0005745	m-AAA complex(GO:0005745)

Gene overrepresentation in molecular function category:

Total log-likelihood	Term	Description
0.1	GO:1990188	euchromatin binding(GO:1990188)
0.3	GO:0003841	1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)
0.2	GO:0008390	testosterone 16-alpha-hydroxylase activity(GO:0008390)
0.1	GO:0008732	threonine aldolase activity(GO:0004793) L-allo-threonine aldolase activity(GO:0008732)
0.1	GO:0051718	DNA (cytosine-5-)-methyltransferase activity(GO:0003886) DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates(GO:0051718)
0.1	GO:0001875	lipopolysaccharide receptor activity(GO:0001875)
0.2	GO:0015093	ferrous iron transmembrane transporter activity(GO:0015093)
0.1	GO:0061513	hexose phosphate transmembrane transporter activity(GO:0015119) organophosphate:inorganic phosphate antiporter activity(GO:0015315) hexose-phosphate:inorganic phosphate antiporter activity(GO:0015526) glucose 6-phosphate:inorganic phosphate antiporter activity(GO:0061513)
0.1	GO:0000171	ribonuclease MRP activity(GO:0000171)
0.3	GO:0038187	signaling pattern recognition receptor activity(GO:0008329) pattern recognition receptor activity(GO:0038187)
0.1	GO:0004468	lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468)
0.2	GO:0019912	cyclin-dependent protein kinase activating kinase activity(GO:0019912)
0.1	GO:0070891	lipoteichoic acid binding(GO:0070891)
0.1	GO:0005332	gamma-aminobutyric acid:sodium symporter activity(GO:0005332)
0.1	GO:0008970	phosphatidylcholine 1-acylhydrolase activity(GO:0008970)
0.1	GO:0005345	purine nucleobase transmembrane transporter activity(GO:0005345) pyrimidine nucleobase transmembrane transporter activity(GO:0005350) nucleobase transmembrane transporter activity(GO:0015205)
0.1	GO:0015349	thyroid hormone transmembrane transporter activity(GO:0015349)
0.1	GO:0036033	mediator complex binding(GO:0036033)
0.1	GO:0050897	cobalt ion binding(GO:0050897)
0.0	GO:0004706	JUN kinase kinase kinase activity(GO:0004706)
0.1	GO:0015319	sodium:inorganic phosphate symporter activity(GO:0015319)
0.1	GO:1901702	urate transmembrane transporter activity(GO:0015143) salt transmembrane transporter activity(GO:1901702)
0.1	GO:0016509	long-chain-3-hydroxyacyl-CoA dehydrogenase activity(GO:0016509)
0.1	GO:0042979	ornithine decarboxylase regulator activity(GO:0042979)
0.1	GO:0070053	thrombospondin receptor activity(GO:0070053)
0.1	GO:0071933	Arp2/3 complex binding(GO:0071933)
0.1	GO:0051864	histone demethylase activity (H3-K36 specific)(GO:0051864)
0.1	GO:0031419	cobalamin binding(GO:0031419)
0.0	GO:0035939	microsatellite binding(GO:0035939)
0.1	GO:0047035	testosterone dehydrogenase (NAD+) activity(GO:0047035)
0.2	GO:0005003	ephrin receptor activity(GO:0005003)
0.1	GO:0015016	[heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.0	GO:0004611	phosphoenolpyruvate carboxykinase activity(GO:0004611)
0.0	GO:0070698	type I activin receptor binding(GO:0070698)
0.1	GO:0004854	xanthine dehydrogenase activity(GO:0004854) oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor(GO:0016726)
0.1	GO:0008349	MAP kinase kinase kinase kinase activity(GO:0008349)
0.0	GO:0004813	alanine-tRNA ligase activity(GO:0004813)
0.1	GO:0004332	fructose-bisphosphate aldolase activity(GO:0004332)
0.1	GO:0003847	1-alkyl-2-acetylglycerophosphocholine esterase activity(GO:0003847)
0.0	GO:0015563	uptake transmembrane transporter activity(GO:0015563)
0.1	GO:0046912	transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
0.1	GO:0005432	calcium:sodium antiporter activity(GO:0005432)
0.1	GO:0004095	carnitine O-palmitoyltransferase activity(GO:0004095)
0.0	GO:0015186	L-asparagine transmembrane transporter activity(GO:0015182) L-glutamine transmembrane transporter activity(GO:0015186)
0.1	GO:0005534	galactose binding(GO:0005534)
0.0	GO:0070905	serine binding(GO:0070905)
0.0	GO:0016822	hydrolase activity, acting on acid carbon-carbon bonds(GO:0016822) hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances(GO:0016823)
0.1	GO:0005499	vitamin D binding(GO:0005499)
0.0	GO:0008525	phosphatidylcholine transporter activity(GO:0008525)
0.0	GO:0043125	ErbB-3 class receptor binding(GO:0043125)
0.1	GO:0030292	protein tyrosine kinase inhibitor activity(GO:0030292)
0.0	GO:0016833	oxo-acid-lyase activity(GO:0016833)
0.1	GO:0017034	Rap guanyl-nucleotide exchange factor activity(GO:0017034)
0.2	GO:0008483	transaminase activity(GO:0008483)
0.1	GO:0005095	GTPase inhibitor activity(GO:0005095)
0.1	GO:0031730	CCR5 chemokine receptor binding(GO:0031730)
0.2	GO:0015026	coreceptor activity(GO:0015026)
0.1	GO:0015379	potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820)
0.0	GO:0043237	laminin-1 binding(GO:0043237)
0.0	GO:0035529	NADH pyrophosphatase activity(GO:0035529)
0.1	GO:0034902	alkyl sulfatase activity(GO:0018741) endosulfan hemisulfate sulfatase activity(GO:0034889) endosulfan sulfate hydrolase activity(GO:0034902)
0.0	GO:0017150	tRNA dihydrouridine synthase activity(GO:0017150)

Gene overrepresentation in curated gene sets: canonical pathways category:

Total log-likelihood	Term	Description
0.2	SA G2 AND M PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.0	SA CASPASE CASCADE	Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.0	ST INTERFERON GAMMA PATHWAY	Interferon gamma pathway.
0.0	PID SHP2 PATHWAY	SHP2 signaling
0.2	PID EPHA2 FWD PATHWAY	EPHA2 forward signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Total log-likelihood	Term	Description
0.2	REACTOME AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL	Genes involved in AKT phosphorylates targets in the cytosol
0.1	REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK	Genes involved in Negative regulation of the PI3K/AKT network
0.2	REACTOME GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTERGRINS	Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins
0.3	REACTOME SIGNALING BY FGFR1 FUSION MUTANTS	Genes involved in Signaling by FGFR1 fusion mutants
0.1	REACTOME COMMON PATHWAY	Genes involved in Common Pathway
0.0	REACTOME PEPTIDE CHAIN ELONGATION	Genes involved in Peptide chain elongation
0.1	REACTOME CREATION OF C4 AND C2 ACTIVATORS	Genes involved in Creation of C4 and C2 activators
0.1	REACTOME REMOVAL OF THE FLAP INTERMEDIATE FROM THE C STRAND	Genes involved in Removal of the Flap Intermediate from the C-strand
0.3	REACTOME SYNTHESIS OF PA	Genes involved in Synthesis of PA
0.1	REACTOME IKK COMPLEX RECRUITMENT MEDIATED BY RIP1	Genes involved in IKK complex recruitment mediated by RIP1
0.1	REACTOME BETA DEFENSINS	Genes involved in Beta defensins
0.1	REACTOME ABACAVIR TRANSPORT AND METABOLISM	Genes involved in Abacavir transport and metabolism
0.0	REACTOME BINDING AND ENTRY OF HIV VIRION	Genes involved in Binding and entry of HIV virion