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ENCSR904DTN: DNase-seq of mouse liver in constant darkness

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Results for Tbx4

Z-value: 0.31

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Transcription factors associated with Tbx4

Gene Symbol	Gene ID	Gene Info
Tbx4 Ensembl NCBI MGI UniProt	ENSMUSG00000000094.6	T-box 4

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
chr11_85893909_85894085	Tbx4	2768	0.243929	-0.18	7.3e-01	Click!

Activity of the Tbx4 motif across conditions

Conditions sorted by the z-value of the Tbx4 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr16_46463130_46463327	0.55	Nectin3	nectin cell adhesion molecule 3	14718	0.27
chr3_31136392_31136619	0.22	Cldn11	claudin 11	13415	0.2
chr1_182500736_182501185	0.13	Gm37069	predicted gene, 37069	6804	0.14
chr19_30146095_30146265	0.11	Gldc	glycine decarboxylase	949	0.57
chr6_112873464_112873750	0.11	Srgap3	SLIT-ROBO Rho GTPase activating protein 3	44148	0.13
chr1_84059698_84059849	0.11	Pid1	phosphotyrosine interaction domain containing 1	6520	0.27
chr14_63265088_63265239	0.10	Gata4	GATA binding protein 4	5961	0.19
chr1_73909397_73909605	0.10	Tns1	tensin 1	18716	0.18
chr3_31136174_31136377	0.09	Cldn11	claudin 11	13645	0.2
chr11_53420114_53420567	0.09	Leap2	liver-expressed antimicrobial peptide 2	2830	0.12
chr9_108297063_108297481	0.09	Amt	aminomethyltransferase	350	0.72
chr11_20826808_20826959	0.09	Lgalsl	lectin, galactoside binding-like	3872	0.18
chr7_112498970_112499146	0.09	Parva	parvin, alpha	20643	0.2
chr2_128567912_128568063	0.09	Gm14006	predicted gene 14006	9753	0.13
chrX_143067335_143067542	0.09	Rtl9	retrotransposon Gag like 9	32156	0.2
chr11_86932862_86933027	0.08	Ypel2	yippee like 2	39080	0.14
chr4_97013861_97014018	0.08	Gm27521	predicted gene, 27521	96919	0.08
chr2_57332734_57332885	0.08	Gm13535	predicted gene 13535	57123	0.11
chr1_193271420_193271628	0.08	G0s2	G0/G1 switch gene 2	1693	0.19
chr4_132196053_132196243	0.07	Ythdf2	YTH N6-methyladenosine RNA binding protein 2	14661	0.08
chr15_75642798_75642949	0.07	2810039B14Rik	RIKEN cDNA 2810039B14 gene	389	0.75
chr13_34645504_34645908	0.07	Pxdc1	PX domain containing 1	2862	0.18
chr15_97161836_97161987	0.07	Gm32885	predicted gene, 32885	5311	0.27
chr15_10718434_10718784	0.07	4930556M19Rik	RIKEN cDNA 4930556M19 gene	758	0.66
chr3_31136684_31136995	0.07	Cldn11	claudin 11	13081	0.2
chr15_95872198_95872364	0.07	Gm25070	predicted gene, 25070	7536	0.19
chr11_22843395_22843546	0.07	Gm23772	predicted gene, 23772	3398	0.15
chr1_171454993_171455144	0.07	F11r	F11 receptor	7782	0.1
chr8_126727960_126728150	0.07	Gm45805	predicted gene 45805	30279	0.2
chr9_48675501_48675665	0.07	Nnmt	nicotinamide N-methyltransferase	70430	0.11
chr2_30386411_30386643	0.07	Miga2	mitoguardin 2	4583	0.1
chr2_30966491_30966663	0.07	Tor1a	torsin family 1, member A (torsin A)	1295	0.32
chr2_155390448_155390624	0.07	Ncoa6	nuclear receptor coactivator 6	6290	0.14
chr13_13753264_13753415	0.07	Lyst	lysosomal trafficking regulator	6603	0.21
chr4_15254591_15254742	0.07	Tmem64	transmembrane protein 64	11165	0.26
chr6_121859844_121860059	0.06	Mug1	murinoglobulin 1	18847	0.19
chr7_45488295_45488657	0.06	Dhdh	dihydrodiol dehydrogenase (dimeric)	329	0.63
chr9_77897902_77898083	0.06	Gm47824	predicted gene, 47824	3537	0.19
chr19_28928421_28928869	0.06	4430402I18Rik	RIKEN cDNA 4430402I18 gene	582	0.68
chr6_97294080_97294296	0.06	Frmd4b	FERM domain containing 4B	2927	0.28
chr7_27452561_27452934	0.06	Blvrb	biliverdin reductase B (flavin reductase (NADPH))	303	0.79
chr2_103454731_103454882	0.06	Elf5	E74-like factor 5	6068	0.19
chr1_58097131_58097333	0.06	Aox3	aldehyde oxidase 3	15898	0.18
chr14_21160817_21160968	0.06	Adk	adenosine kinase	84740	0.09
chr5_122494527_122494678	0.06	Gm43360	predicted gene 43360	306	0.77
chr1_93124444_93124635	0.06	Gm28086	predicted gene 28086	436	0.76
chr16_17892250_17892653	0.06	Dgcr2	DiGeorge syndrome critical region gene 2	758	0.3
chr8_122677096_122677352	0.06	Cbfa2t3	CBFA2/RUNX1 translocation partner 3	848	0.44
chr15_102181335_102181499	0.06	Csad	cysteine sulfinic acid decarboxylase	1556	0.24
chr13_60709526_60709699	0.06	Dapk1	death associated protein kinase 1	13199	0.17
chr14_73045910_73046229	0.06	Cysltr2	cysteinyl leukotriene receptor 2	3003	0.3
chr14_55468841_55469329	0.06	Dhrs4	dehydrogenase/reductase (SDR family) member 4	9673	0.1
chr1_130734318_130734676	0.06	AA986860	expressed sequence AA986860	2387	0.14
chr18_36726531_36726874	0.06	Cd14	CD14 antigen	36	0.94
chrX_60339140_60339308	0.06	Mir505	microRNA 505	55268	0.12
chr16_24460066_24460246	0.06	Lpp	LIM domain containing preferred translocation partner in lipoma	12065	0.21
chr11_75437280_75437567	0.06	Serpinf2	serine (or cysteine) peptidase inhibitor, clade F, member 2	1477	0.2
chr5_96455228_96455379	0.06	Gm33050	predicted gene, 33050	2440	0.34
chr16_16888784_16888935	0.06	Top3b	topoisomerase (DNA) III beta	1020	0.34
chr13_62927255_62927442	0.06	Gm48812	predicted gene, 48812	22094	0.13
chr4_144900352_144900520	0.06	Dhrs3	dehydrogenase/reductase (SDR family) member 3	7217	0.22
chr10_84424760_84424911	0.06	Nuak1	NUAK family, SNF1-like kinase, 1	15762	0.15
chr19_47580710_47580962	0.06	Slk	STE20-like kinase	817	0.55
chr18_84590910_84591391	0.06	Zfp407	zinc finger protein 407	1425	0.41
chr2_129101432_129101630	0.06	Polr1b	polymerase (RNA) I polypeptide B	504	0.68
chr11_102211338_102211489	0.06	Hdac5	histone deacetylase 5	7515	0.09
chr18_35849301_35849452	0.06	Cxxc5	CXXC finger 5	5311	0.11
chr16_10757949_10758100	0.06	Socs1	suppressor of cytokine signaling 1	27512	0.08
chr5_145861209_145861775	0.06	Cyp3a11	cytochrome P450, family 3, subfamily a, polypeptide 11	15199	0.15
chr9_71028459_71028669	0.06	Lipc	lipase, hepatic	76338	0.09
chr9_110703228_110703412	0.06	Ccdc12	coiled-coil domain containing 12	6574	0.12
chr11_120526901_120527125	0.06	Gm11789	predicted gene 11789	3541	0.08
chr11_106581287_106581448	0.06	Tex2	testis expressed gene 2	767	0.66
chr13_34646953_34647104	0.06	Pxdc1	PX domain containing 1	1540	0.29
chr11_107010555_107010708	0.05	Gm11708	predicted gene 11708	5891	0.14
chr6_30302088_30302239	0.05	Ube2h	ubiquitin-conjugating enzyme E2H	2359	0.22
chr3_83996881_83997402	0.05	Tmem131l	transmembrane 131 like	28913	0.2
chr1_75537481_75537658	0.05	Stk11ip	serine/threonine kinase 11 interacting protein	4531	0.1
chr15_75996647_75996807	0.05	Mapk15	mitogen-activated protein kinase 15	14	0.94
chr9_21730832_21730991	0.05	Ldlr	low density lipoprotein receptor	5196	0.13
chr10_21448325_21448476	0.05	Gm48386	predicted gene, 48386	2764	0.21
chr12_103956422_103956789	0.05	Serpina1e	serine (or cysteine) peptidase inhibitor, clade A, member 1E	293	0.83
chr2_158199719_158199870	0.05	1700060C20Rik	RIKEN cDNA 1700060C20 gene	7786	0.15
chr2_29437237_29437388	0.05	Gm24976	predicted gene, 24976	21882	0.15
chr17_66859168_66859319	0.05	Gm49940	predicted gene, 49940	2997	0.22
chr1_181005812_181005979	0.05	Ephx1	epoxide hydrolase 1, microsomal	9725	0.09
chr9_110582758_110582909	0.05	Setd2	SET domain containing 2	8949	0.13
chr6_5512042_5512193	0.05	Pdk4	pyruvate dehydrogenase kinase, isoenzyme 4	15808	0.27
chr11_109474178_109474329	0.05	Slc16a6	solute carrier family 16 (monocarboxylic acid transporters), member 6	655	0.45
chr12_17747270_17747517	0.05	Hpcal1	hippocalcin-like 1	19167	0.21
chr6_108837450_108837611	0.05	Edem1	ER degradation enhancer, mannosidase alpha-like 1	1120	0.56
chr4_107159322_107159488	0.05	Tceanc2	transcription elongation factor A (SII) N-terminal and central domain containing 2	18263	0.12
chr14_105253422_105253603	0.05	Gm22290	predicted gene, 22290	3502	0.18
chr4_106920101_106920437	0.05	Ssbp3	single-stranded DNA binding protein 3	2916	0.28
chr2_26553954_26554132	0.05	Gm13358	predicted gene 13358	4582	0.11
chr10_62980659_62980890	0.05	Rufy2	RUN and FYVE domain-containing 2	481	0.66
chr5_151232835_151233036	0.05	Stard13	StAR-related lipid transfer (START) domain containing 13	839	0.64
chr4_132489447_132489680	0.05	Gm12981	predicted gene 12981	20086	0.09
chr15_81360014_81360383	0.05	Slc25a17	solute carrier family 25 (mitochondrial carrier, peroxisomal membrane protein), member 17	529	0.71
chr17_29093649_29093812	0.05	Cdkn1a	cyclin-dependent kinase inhibitor 1A (P21)	39	0.91
chr18_6507791_6507957	0.05	Epc1	enhancer of polycomb homolog 1	8234	0.17
chr2_104123492_104123669	0.05	A930018P22Rik	RIKEN cDNA A930018P22 gene	811	0.53
chr13_113023428_113023726	0.05	Cdc20b	cell division cycle 20B	11534	0.08
chr3_116424764_116424926	0.05	Cdc14a	CDC14 cell division cycle 14A	813	0.56
chr2_92056065_92056235	0.05	2900072N19Rik	RIKEN cDNA 2900072N19 gene	3219	0.2
chr5_137986079_137986259	0.05	Azgp1	alpha-2-glycoprotein 1, zinc	4601	0.1
chr18_44633494_44633779	0.05	A930012L18Rik	RIKEN cDNA A930012L18 gene	28029	0.19
chr13_113602672_113602866	0.05	Snx18	sorting nexin 18	10872	0.17
chr2_126569048_126569199	0.05	Slc27a2	solute carrier family 27 (fatty acid transporter), member 2	4363	0.22
chr8_124589098_124589249	0.05	Capn9	calpain 9	13060	0.16
chr7_90141326_90141489	0.05	Gm45222	predicted gene 45222	4541	0.13
chr1_166410038_166410239	0.05	Pogk	pogo transposable element with KRAB domain	275	0.88
chr17_84990758_84990958	0.05	Ppm1b	protein phosphatase 1B, magnesium dependent, beta isoform	2815	0.25
chr6_58832026_58832202	0.05	Herc3	hect domain and RLD 3	253	0.93
chr19_42054767_42054919	0.05	4933411K16Rik	RIKEN cDNA 4933411K16 gene	2595	0.16
chr3_28025480_28025631	0.05	Pld1	phospholipase D1	5707	0.3
chr9_121906088_121906239	0.05	Ackr2	atypical chemokine receptor 2	1	0.95
chr7_141070384_141070555	0.05	B4galnt4	beta-1,4-N-acetyl-galactosaminyl transferase 4	133	0.9
chr19_55549970_55550134	0.05	Vti1a	vesicle transport through interaction with t-SNAREs 1A	169038	0.03
chr6_28736579_28736738	0.05	Snd1	staphylococcal nuclease and tudor domain containing 1	28032	0.19
chr2_31517780_31518546	0.04	Ass1	argininosuccinate synthetase 1	327	0.88
chr11_79230285_79230459	0.04	Wsb1	WD repeat and SOCS box-containing 1	12577	0.16
chr2_6074858_6075460	0.04	Upf2	UPF2 regulator of nonsense transcripts homolog (yeast)	24732	0.16
chr6_108102731_108102882	0.04	Sumf1	sulfatase modifying factor 1	24257	0.18
chr7_80111711_80111884	0.04	Gm45203	predicted gene 45203	837	0.46
chr11_100859548_100859739	0.04	Stat5a	signal transducer and activator of transcription 5A	13	0.97
chr12_99530270_99530421	0.04	Foxn3	forkhead box N3	33163	0.12
chr3_58685911_58686282	0.04	Siah2	siah E3 ubiquitin protein ligase 2	59	0.96
chr1_40790200_40790542	0.04	Mfsd9	major facilitator superfamily domain containing 9	286	0.89
chr4_144896227_144896412	0.04	Dhrs3	dehydrogenase/reductase (SDR family) member 3	3100	0.28
chr17_31383992_31384162	0.04	Pde9a	phosphodiesterase 9A	2133	0.25
chr11_50199089_50199272	0.04	Sqstm1	sequestosome 1	3774	0.13
chr9_66918909_66919116	0.04	Rab8b	RAB8B, member RAS oncogene family	675	0.66
chr13_46818454_46818623	0.04	Kif13a	kinesin family member 13A	9481	0.19
chr11_52364094_52364245	0.04	Vdac1	voltage-dependent anion channel 1	3034	0.23
chr14_73176868_73177019	0.04	Rcbtb2	regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2	2492	0.24
chr2_168085703_168085998	0.04	Pard6b	par-6 family cell polarity regulator beta	4846	0.16
chr14_60784862_60785284	0.04	Mipep	mitochondrial intermediate peptidase	435	0.5
chr6_115464997_115465148	0.04	Gm44079	predicted gene, 44079	82	0.97
chr7_99176016_99176394	0.04	Dgat2	diacylglycerol O-acyltransferase 2	4088	0.15
chr10_128376319_128376655	0.04	Ankrd52	ankyrin repeat domain 52	628	0.38
chr6_70790677_70790915	0.04	Rpia	ribose 5-phosphate isomerase A	1207	0.42
chr1_134234537_134234704	0.04	Adora1	adenosine A1 receptor	42	0.97
chr9_115400503_115400904	0.04	Gm9487	predicted gene 9487	4446	0.15
chr6_149144748_149145030	0.04	Etfbkmt	electron transfer flavoprotein beta subunit lysine methyltransferase	3243	0.17
chr6_29516787_29517146	0.04	Kcp	kielin/chordin-like protein	9014	0.1
chr15_102442382_102442533	0.04	Amhr2	anti-Mullerian hormone type 2 receptor	2910	0.13
chr9_110390754_110390978	0.04	Ptpn23	protein tyrosine phosphatase, non-receptor type 23	391	0.77
chr17_27817988_27818406	0.04	Ilrun	inflammation and lipid regulator with UBA-like and NBR1-like domains	2255	0.2
chr14_47475021_47475196	0.04	Fbxo34	F-box protein 34	931	0.45
chr17_6828357_6828615	0.04	4933426B08Rik	RIKEN cDNA 4933426B08 gene	19977	0.14
chr8_124291752_124291934	0.04	Galnt2	polypeptide N-acetylgalactosaminyltransferase 2	3260	0.21
chr6_31400666_31400852	0.04	Mkln1	muskelin 1, intracellular mediator containing kelch motifs	1900	0.25
chr4_107159764_107160176	0.04	Tceanc2	transcription elongation factor A (SII) N-terminal and central domain containing 2	17698	0.12
chr12_76838153_76838373	0.04	Fntb	farnesyltransferase, CAAX box, beta	830	0.6
chr14_63143112_63143263	0.04	Ctsb	cathepsin B	7669	0.14
chr11_70741343_70741494	0.04	Gm12320	predicted gene 12320	13733	0.08
chr10_59884883_59885114	0.04	Dnajb12	DnaJ heat shock protein family (Hsp40) member B12	5372	0.16
chr1_88044569_88044899	0.04	AC087801.1	UDP glycosyltransferase 1 family (Ytg1) pseudogene	7134	0.08
chr3_143103418_143103577	0.04	Gm43614	predicted gene 43614	4451	0.28
chr7_144181012_144181177	0.04	Shank2	SH3 and multiple ankyrin repeat domains 2	5565	0.28
chr1_39545677_39545839	0.04	Snord89	small nucleolar RNA, C/D box 89	3096	0.14
chr16_41258426_41258587	0.04	Gm47276	predicted gene, 47276	40729	0.18
chr13_91748935_91749127	0.04	Gm27656	predicted gene, 27656	3075	0.19
chr13_51646798_51647087	0.04	Gm22806	predicted gene, 22806	1257	0.35
chr6_87846724_87847004	0.04	Cnbp	cellular nucleic acid binding protein	547	0.54
chr6_146473719_146473882	0.04	Gm15720	predicted gene 15720	10193	0.19
chr1_52816740_52816904	0.04	Inpp1	inositol polyphosphate-1-phosphatase	629	0.71
chr1_179587103_179587284	0.04	Cnst	consortin, connexin sorting protein	6197	0.2
chr12_17505824_17505980	0.04	Odc1	ornithine decarboxylase, structural 1	38892	0.11
chr9_69293134_69293313	0.04	Rora	RAR-related orphan receptor alpha	3541	0.3
chr7_13007324_13007475	0.04	Zbtb45	zinc finger and BTB domain containing 45	2401	0.12
chr18_39397194_39397356	0.04	Gm15337	predicted gene 15337	7850	0.22
chr2_30470118_30470322	0.04	Ier5l	immediate early response 5-like	3999	0.16
chr7_30947968_30948300	0.04	Hamp	hepcidin antimicrobial peptide	4102	0.08
chr9_44605679_44605889	0.04	Ddx6	DEAD (Asp-Glu-Ala-Asp) box polypeptide 6	887	0.32
chr1_172082204_172082395	0.04	Copa	coatomer protein complex subunit alpha	230	0.7
chr1_159234206_159234548	0.04	Gm37115	predicted gene, 37115	1333	0.34
chr9_122355767_122356085	0.04	Abhd5	abhydrolase domain containing 5	4137	0.17
chr1_132349189_132349347	0.04	F730311O21Rik	RIKEN cDNA F730311O21 gene	7245	0.12
chr4_115088632_115088790	0.04	Pdzk1ip1	PDZK1 interacting protein 1	3	0.97
chr5_72652767_72652918	0.04	Nipal1	NIPA-like domain containing 1	5000	0.13
chr9_77749808_77749964	0.04	Gclc	glutamate-cysteine ligase, catalytic subunit	4649	0.16
chr2_18695636_18696007	0.04	Spag6	sperm associated antigen 6	1769	0.28
chr19_25402768_25403114	0.04	Kank1	KN motif and ankyrin repeat domains 1	3758	0.26
chr14_12103232_12103447	0.04	Ptprg	protein tyrosine phosphatase, receptor type, G	12179	0.23
chr3_98297519_98297734	0.04	Gm43189	predicted gene 43189	10638	0.14
chr17_34733622_34734232	0.04	C4b	complement component 4B (Chido blood group)	2172	0.12
chr4_137875186_137875337	0.04	Gm13012	predicted gene 13012	8151	0.2
chr7_100120840_100121149	0.04	Pold3	polymerase (DNA-directed), delta 3, accessory subunit	84	0.96
chr16_58514608_58514781	0.04	St3gal6	ST3 beta-galactoside alpha-2,3-sialyltransferase 6	510	0.79
chr4_117330125_117330465	0.04	Rnf220	ring finger protein 220	30267	0.11
chr2_85071327_85071510	0.04	Tnks1bp1	tankyrase 1 binding protein 1	10454	0.12
chr15_59783186_59783337	0.04	Gm19510	predicted gene, 19510	11698	0.26
chr7_114089047_114089263	0.04	Gm45615	predicted gene 45615	2257	0.36
chr1_130761129_130761587	0.04	Gm28856	predicted gene 28856	5026	0.11
chr3_94581546_94582033	0.04	Snx27	sorting nexin family member 27	760	0.44
chr8_70719113_70719264	0.04	Gm3336	predicted gene 3336	645	0.45
chr9_72661312_72661471	0.04	Nedd4	neural precursor cell expressed, developmentally down-regulated 4	955	0.38
chr17_46484376_46484539	0.04	Ttbk1	tau tubulin kinase 1	162	0.91

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of Tbx4

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Total log-likelihood	Term	Description
0.1	GO:0019464	glycine catabolic process(GO:0006546) glycine decarboxylation via glycine cleavage system(GO:0019464)
0.1	GO:0071727	response to triacyl bacterial lipopeptide(GO:0071725) cellular response to triacyl bacterial lipopeptide(GO:0071727)
0.0	GO:0010046	response to mycotoxin(GO:0010046)
0.0	GO:0046544	development of secondary male sexual characteristics(GO:0046544)
0.0	GO:0046149	heme catabolic process(GO:0042167) pigment catabolic process(GO:0046149)
0.0	GO:0055118	negative regulation of cardiac muscle contraction(GO:0055118)
0.0	GO:0042732	D-xylose metabolic process(GO:0042732)
0.0	GO:1901078	negative regulation of relaxation of muscle(GO:1901078)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.0	GO:0005347	ATP transmembrane transporter activity(GO:0005347)

Results for Tbx4

Z-value: 0.31

Motif logo

Transcription factors associated with Tbx4

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

Activity of the Tbx4 motif across conditions

Conditions sorted by the z-value of the Tbx4 motif activity

Top target CREs of the motif:

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of Tbx4

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in molecular function category: