Project

ENCSR904DTN: DNase-seq of mouse liver in constant darkness

Navigation

Downloads

CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for Tbx5

Z-value: 0.79

Motif logo

Transcription factors associated with Tbx5

Gene Symbol	Gene ID	Gene Info
Tbx5 Ensembl NCBI MGI UniProt	ENSMUSG00000018263.8	Tbx5

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

Gene	Promoter	Distance	Association probability	Pearson corr. coef.	P-value	Plot
Tbx5	chr5_119839110_119839360	3080	0.227585	-0.16	7.6e-01	Click!

Activity of the Tbx5 motif across conditions

Conditions sorted by the z-value of the Tbx5 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr2_31517780_31518546	0.34	Ass1	argininosuccinate synthetase 1	327	0.88
chr10_117649861_117650065	0.30	Gm25709	predicted gene, 25709	12425	0.13
chr4_117116805_117116956	0.30	Ptch2	patched 2	3456	0.09
chrX_169982545_169982696	0.29	Gm15726	predicted gene 15726	2612	0.19
chr17_45873270_45873443	0.28	4930542M03Rik	RIKEN cDNA 4930542M03 gene	8096	0.17
chr3_83043842_83044694	0.26	Fgb	fibrinogen beta chain	5595	0.15
chr7_89699637_89700074	0.25	Me3	malic enzyme 3, NADP(+)-dependent, mitochondrial	36876	0.14
chr3_51254730_51254881	0.22	Elf2	E74-like factor 2	5436	0.14
chr8_119416779_119416930	0.21	Osgin1	oxidative stress induced growth inhibitor 1	17270	0.13
chr8_119417171_119417322	0.21	Osgin1	oxidative stress induced growth inhibitor 1	16878	0.13
chr3_28025480_28025631	0.21	Pld1	phospholipase D1	5707	0.3
chr7_13007324_13007475	0.21	Zbtb45	zinc finger and BTB domain containing 45	2401	0.12
chr12_109798285_109798857	0.21	Gm9661	predicted gene 9661	28432	0.03
chr2_26314444_26314595	0.20	Gpsm1	G-protein signalling modulator 1 (AGS3-like, C. elegans)	996	0.38
chr16_25221689_25221840	0.20	Tprg	transformation related protein 63 regulated	65053	0.14
chr19_4033739_4033961	0.19	Gstp1	glutathione S-transferase, pi 1	2143	0.11
chr3_100892764_100892976	0.19	Trim45	tripartite motif-containing 45	29332	0.16
chr9_98424555_98424727	0.19	Rbp1	retinol binding protein 1, cellular	1680	0.4
chr8_46483334_46483691	0.19	Acsl1	acyl-CoA synthetase long-chain family member 1	7454	0.16
chr18_63901771_63901922	0.18	Gm19076	predicted gene, 19076	2815	0.29
chr2_31519156_31519420	0.18	Ass1	argininosuccinate synthetase 1	798	0.61
chr11_83740503_83740922	0.18	Wfdc21	WAP four-disulfide core domain 21	6228	0.1
chr8_12798830_12798981	0.18	Atp11a	ATPase, class VI, type 11A	12511	0.15
chrX_140539340_140539749	0.18	Tsc22d3	TSC22 domain family, member 3	3124	0.26
chr11_118454196_118454347	0.17	Gm11747	predicted gene 11747	724	0.56
chr2_25095172_25095346	0.17	Noxa1	NADPH oxidase activator 1	110	0.92
chr11_16881299_16881793	0.17	Egfr	epidermal growth factor receptor	3396	0.26
chr9_98423199_98423389	0.17	Rbp1	retinol binding protein 1, cellular	333	0.9
chr5_139822534_139822685	0.17	Tmem184a	transmembrane protein 184a	2692	0.17
chr9_85551927_85552078	0.17	Gm48834	predicted gene, 48834	1763	0.42
chr15_88866027_88866463	0.17	Pim3	proviral integration site 3	1325	0.34
chr7_98415563_98415739	0.17	Gm44507	predicted gene 44507	27	0.97
chr10_98652216_98652384	0.17	Gm5427	predicted gene 5427	47410	0.18
chr16_23967660_23967916	0.17	Bcl6	B cell leukemia/lymphoma 6	4592	0.19
chr10_93492422_93492688	0.17	Hal	histidine ammonia lyase	3752	0.18
chr9_121906088_121906239	0.16	Ackr2	atypical chemokine receptor 2	1	0.95
chr11_97383324_97383535	0.16	Socs7	suppressor of cytokine signaling 7	5992	0.15
chr11_117322484_117322692	0.16	Septin9	septin 9	3845	0.24
chr14_41120981_41121358	0.16	Sftpa1	surfactant associated protein A1	10613	0.11
chr17_86208576_86208727	0.16	AC154542.1	TEC	33076	0.17
chr11_101372782_101373038	0.16	G6pc	glucose-6-phosphatase, catalytic	5349	0.06
chr6_34412803_34412954	0.16	Akr1b7	aldo-keto reductase family 1, member B7	544	0.69
chr11_116180328_116180538	0.16	Acox1	acyl-Coenzyme A oxidase 1, palmitoyl	781	0.44
chr17_56005828_56005982	0.16	Mpnd	MPN domain containing	194	0.61
chr17_8974900_8975051	0.16	1700010I14Rik	RIKEN cDNA 1700010I14 gene	13358	0.23
chr12_110203702_110203885	0.16	Gm34785	predicted gene, 34785	15732	0.12
chr6_86665663_86665814	0.15	Gm44292	predicted gene, 44292	187	0.89
chr2_144308533_144308857	0.15	Ovol2	ovo like zinc finger 2	22631	0.09
chr19_46029534_46029692	0.15	Ldb1	LIM domain binding 1	5265	0.14
chr7_92681661_92681812	0.15	Pcf11	PCF11 cleavage and polyadenylation factor subunit	11802	0.12
chr2_155063372_155063735	0.15	Gm45609	predicted gene 45609	10628	0.13
chr1_88960128_88960297	0.15	Gm4753	predicted gene 4753	27893	0.17
chr5_120480072_120480223	0.15	Sds	serine dehydratase	216	0.8
chr18_11144853_11145048	0.15	Gata6	GATA binding protein 6	85903	0.09
chr7_84596857_84597020	0.15	Fah	fumarylacetoacetate hydrolase	5162	0.17
chr4_41637175_41637517	0.15	Gm12406	predicted gene 12406	2032	0.17
chr19_44997151_44997302	0.15	Sema4g	sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G	5090	0.11
chr17_39846008_39846161	0.15	CT010467.1	18s RNA, related sequence 5	269	0.9
chr6_134078837_134079020	0.15	Gm43982	predicted gene, 43982	5574	0.2
chr3_102187285_102187460	0.15	Vangl1	VANGL planar cell polarity 1	10533	0.14
chr4_150592192_150592343	0.14	Rere	arginine glutamic acid dipeptide (RE) repeats	22610	0.17
chr9_78586353_78586504	0.14	Slc17a5	solute carrier family 17 (anion/sugar transporter), member 5	1587	0.33
chr10_24911578_24911812	0.14	Mir6905	microRNA 6905	1031	0.42
chr7_19496130_19496424	0.14	Exoc3l2	exocyst complex component 3-like 2	7221	0.08
chr4_135231252_135231420	0.14	Clic4	chloride intracellular channel 4 (mitochondrial)	41478	0.11
chr7_140765024_140765175	0.14	Cyp2e1	cytochrome P450, family 2, subfamily e, polypeptide 1	618	0.54
chr11_98772948_98773272	0.14	Nr1d1	nuclear receptor subfamily 1, group D, member 1	2223	0.16
chr2_31473064_31473684	0.14	Ass1	argininosuccinate synthetase 1	3167	0.24
chr14_101854215_101854466	0.14	Lmo7	LIM domain only 7	13521	0.26
chr7_122971788_122971939	0.14	Rbbp6	retinoblastoma binding protein 6, ubiquitin ligase	945	0.45
chr11_115246492_115246668	0.14	Gm25837	predicted gene, 25837	6698	0.11
chr17_9663030_9663198	0.14	Pabpc6	poly(A) binding protein, cytoplasmic 6	6603	0.26
chr15_81481395_81481613	0.14	Gm49406	predicted gene, 49406	4877	0.14
chr3_96567003_96567180	0.14	Gm15441	predicted gene 15441	290	0.76
chr4_117125610_117126073	0.14	Btbd19	BTB (POZ) domain containing 19	116	0.86
chr7_113913919_113914070	0.14	Spon1	spondin 1, (f-spondin) extracellular matrix protein	147820	0.04
chr4_152165673_152165840	0.14	Hes2	hes family bHLH transcription factor 2	6207	0.12
chr17_46131243_46131394	0.14	Rsph9	radial spoke head 9 homolog (Chlamydomonas)	5477	0.12
chr7_113935146_113935310	0.14	Gm45615	predicted gene 45615	151670	0.04
chr16_87690191_87690394	0.14	Bach1	BTB and CNC homology 1, basic leucine zipper transcription factor 1	8653	0.22
chr8_77486943_77487275	0.13	0610038B21Rik	RIKEN cDNA 0610038B21 gene	29947	0.14
chr2_174343758_174344168	0.13	Gnas	GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus	349	0.83
chr8_36291164_36291366	0.13	Lonrf1	LON peptidase N-terminal domain and ring finger 1	41749	0.14
chr15_31259637_31259788	0.13	Dap	death-associated protein	8624	0.16
chr11_43889353_43889625	0.13	Adra1b	adrenergic receptor, alpha 1b	11721	0.25
chr2_167722273_167722608	0.13	A530013C23Rik	RIKEN cDNA A530013C23 gene	31259	0.1
chr13_9052712_9052890	0.13	Gm36264	predicted gene, 36264	23650	0.12
chr17_78714751_78714902	0.13	Strn	striatin, calmodulin binding protein	22370	0.14
chr3_121195173_121195348	0.13	Gm5710	predicted gene 5710	14163	0.14
chr19_46108526_46108716	0.13	Gm50306	predicted gene, 50306	16309	0.11
chr6_48492947_48493147	0.13	Sspo	SCO-spondin	733	0.46
chr4_127034401_127034573	0.13	Gm12940	predicted gene 12940	756	0.49
chr4_109406664_109406986	0.13	Ttc39a	tetratricopeptide repeat domain 39A	202	0.83
chr4_118149267_118149447	0.13	Kdm4a	lysine (K)-specific demethylase 4A	2598	0.22
chr17_25756148_25756299	0.13	Msln	mesothelin	1845	0.11
chr2_135854498_135854679	0.13	Plcb4	phospholipase C, beta 4	33106	0.19
chr2_124902813_124902964	0.13	Slc24a5	solute carrier family 24, member 5	165236	0.03
chr9_44665366_44665550	0.13	Gm3953	predicted gene 3953	742	0.4
chr2_51823121_51823300	0.13	Gm13492	predicted gene 13492	4641	0.25
chr1_186261473_186261624	0.13	Gm37272	predicted gene, 37272	79291	0.09
chr15_97682260_97682559	0.13	Rpap3	RNA polymerase II associated protein 3	210	0.94
chr5_33901574_33901762	0.13	Mir7024	microRNA 7024	2697	0.18
chr11_102755530_102755686	0.13	Adam11	a disintegrin and metallopeptidase domain 11	5831	0.12
chr6_72360016_72360452	0.13	Rnf181	ring finger protein 181	833	0.41
chr17_34733622_34734232	0.13	C4b	complement component 4B (Chido blood group)	2172	0.12
chr16_30755886_30756050	0.13	Gm49754	predicted gene, 49754	37287	0.15
chr9_111148401_111148693	0.13	Lrrfip2	leucine rich repeat (in FLII) interacting protein 2	12756	0.17
chr10_37247416_37247567	0.13	4930543K20Rik	RIKEN cDNA 4930543K20 gene	16257	0.24
chr15_81355699_81355864	0.13	Slc25a17	solute carrier family 25 (mitochondrial carrier, peroxisomal membrane protein), member 17	4946	0.16
chr8_126801964_126802115	0.13	A630001O12Rik	RIKEN cDNA A630001O12 gene	37194	0.15
chr15_81480824_81481310	0.13	Gm49406	predicted gene, 49406	5314	0.14
chr6_121159588_121159765	0.13	Pex26	peroxisomal biogenesis factor 26	23991	0.12
chr3_144109828_144110050	0.12	Gm34078	predicted gene, 34078	25815	0.2
chr13_23285684_23285835	0.12	4933404K08Rik	RIKEN cDNA 4933404K08 gene	7409	0.08
chr3_51252801_51253044	0.12	Elf2	E74-like factor 2	7319	0.13
chr15_85354161_85354332	0.12	Gm23517	predicted gene, 23517	2992	0.27
chr2_173633527_173633866	0.12	Ppp4r1l-ps	protein phosphatase 4, regulatory subunit 1-like, pseudogene	4146	0.21
chr10_85103179_85103555	0.12	Tmem263	transmembrane protein 263	624	0.52
chr6_138128655_138128834	0.12	Mgst1	microsomal glutathione S-transferase 1	11572	0.26
chr16_45377470_45377621	0.12	Cd200	CD200 antigen	22767	0.16
chr7_45150438_45150589	0.12	Aldh16a1	aldehyde dehydrogenase 16 family, member A1	1334	0.13
chr14_68390472_68390641	0.12	Gm31227	predicted gene, 31227	71075	0.11
chr17_56074297_56074510	0.12	Ubxn6	UBX domain protein 6	144	0.9
chr10_69126441_69126619	0.12	Gm24172	predicted gene, 24172	6352	0.17
chr19_8952481_8952632	0.12	Tut1	terminal uridylyl transferase 1, U6 snRNA-specific	1291	0.2
chr13_80885948_80886129	0.12	Arrdc3	arrestin domain containing 3	57	0.89
chr19_46587795_46587964	0.12	Sfxn2	sideroflexin 2	3242	0.18
chr8_60491849_60492091	0.12	Gm10283	predicted gene 10283	11228	0.22
chr1_67189193_67189422	0.12	Gm15668	predicted gene 15668	59893	0.11
chr1_67134415_67135075	0.12	Cps1	carbamoyl-phosphate synthetase 1	11719	0.24
chr4_102966036_102966207	0.12	Sgip1	SH3-domain GRB2-like (endophilin) interacting protein 1	3765	0.19
chr1_39192284_39192607	0.12	Npas2	neuronal PAS domain protein 2	1286	0.45
chr11_119105318_119105491	0.12	Gm11754	predicted gene 11754	6021	0.15
chr18_35277643_35277851	0.12	Gm50146	predicted gene, 50146	13718	0.16
chr1_192061757_192061908	0.12	Traf5	TNF receptor-associated factor 5	2670	0.19
chr2_164161443_164161616	0.12	n-R5s207	nuclear encoded rRNA 5S 207	4008	0.11
chr7_145044142_145044344	0.12	Ccnd1	cyclin D1	104318	0.05
chr11_102749526_102749741	0.12	Adam11	a disintegrin and metallopeptidase domain 11	11806	0.11
chr14_76623735_76623902	0.12	Fkbp1a-ps1	FK506 binding protein 1a, pseudogene 1	13046	0.21
chr4_118247695_118247892	0.12	Ptprf	protein tyrosine phosphatase, receptor type, F	11348	0.17
chr11_116389158_116389441	0.12	Rnf157	ring finger protein 157	1894	0.21
chr10_71857688_71857856	0.12	Gm22937	predicted gene, 22937	40264	0.15
chr3_130660210_130660361	0.12	Etnppl	ethanolamine phosphate phospholyase	33765	0.11
chr2_31496143_31496706	0.12	Ass1	argininosuccinate synthetase 1	1348	0.43
chr12_75851882_75852228	0.12	Syne2	spectrin repeat containing, nuclear envelope 2	675	0.77
chr8_36223220_36223376	0.12	Lonrf1	LON peptidase N-terminal domain and ring finger 1	26218	0.14
chr11_3287201_3287367	0.12	Patz1	POZ (BTB) and AT hook containing zinc finger 1	1590	0.26
chr14_30909356_30909712	0.11	Itih3	inter-alpha trypsin inhibitor, heavy chain 3	4595	0.13
chr19_10187571_10187722	0.11	Mir6993	microRNA 6993	3729	0.12
chr13_111601521_111601690	0.11	Gm10736	predicted gene 10736	7994	0.13
chr8_71377251_71377402	0.11	Nr2f6	nuclear receptor subfamily 2, group F, member 6	1536	0.21
chr17_56273355_56273537	0.11	Ticam1	toll-like receptor adaptor molecule 1	3340	0.12
chr10_7852226_7852377	0.11	Gm24726	predicted gene, 24726	3820	0.16
chr4_95640632_95640805	0.11	Fggy	FGGY carbohydrate kinase domain containing	3831	0.31
chr8_106074831_106075102	0.11	Nfatc3	nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 3	15333	0.1
chr6_120926829_120927234	0.11	Mical3	microtubule associated monooxygenase, calponin and LIM domain containing 3	8504	0.12
chr5_28076176_28076405	0.11	Insig1	insulin induced gene 1	1624	0.34
chr5_107874706_107874894	0.11	Evi5	ecotropic viral integration site 5	244	0.86
chr8_108745611_108745766	0.11	Gm38042	predicted gene, 38042	8095	0.24
chr18_53927118_53927269	0.11	Csnk1g3	casein kinase 1, gamma 3	5051	0.29
chr8_116351879_116352235	0.11	1700018P08Rik	RIKEN cDNA 1700018P08 gene	5004	0.32
chr9_67869712_67870477	0.11	Vps13c	vacuolar protein sorting 13C	29682	0.17
chr7_113228562_113228716	0.11	Arntl	aryl hydrocarbon receptor nuclear translocator-like	5984	0.23
chr15_99096799_99097225	0.11	Dnajc22	DnaJ heat shock protein family (Hsp40) member C22	2400	0.14
chr1_98713946_98714114	0.11	Gm29460	predicted gene 29460	50811	0.17
chr11_98459290_98459441	0.11	Grb7	growth factor receptor bound protein 7	5576	0.1
chr8_124573046_124573209	0.11	Capn9	calpain 9	2984	0.21
chrX_12189621_12189798	0.11	Gm14521	predicted gene 14521	9642	0.24
chr14_65972599_65972894	0.11	Clu	clusterin	1443	0.35
chr17_31319478_31319804	0.11	Slc37a1	solute carrier family 37 (glycerol-3-phosphate transporter), member 1	465	0.76
chr7_99935891_99936042	0.11	Gm18959	predicted gene, 18959	9096	0.12
chr16_4371080_4371246	0.11	Adcy9	adenylate cyclase 9	48424	0.12
chr15_12010383_12010678	0.11	Sub1	SUB1 homolog, transcriptional regulator	13547	0.16
chr10_81408031_81408226	0.11	Nfic	nuclear factor I/C	487	0.49
chr7_63922331_63923024	0.11	Klf13	Kruppel-like factor 13	2193	0.22
chr15_75827912_75828063	0.11	Zc3h3	zinc finger CCCH type containing 3	222	0.88
chr1_188813741_188813916	0.11	Gm25269	predicted gene, 25269	53352	0.16
chr19_16181317_16181503	0.11	E030024N20Rik	RIKEN cDNA E030024N20 gene	16605	0.2
chr15_31252945_31253125	0.11	Dap	death-associated protein	15301	0.15
chr5_53278040_53278387	0.11	Smim20	small integral membrane protein 20	1095	0.48
chr6_72158619_72158820	0.11	Gm38832	predicted gene, 38832	4130	0.17
chr2_31485093_31485244	0.11	Ass1	argininosuccinate synthetase 1	12604	0.18
chr4_104822600_104822778	0.11	C8b	complement component 8, beta polypeptide	23481	0.18
chr2_167959698_167959868	0.11	Ptpn1	protein tyrosine phosphatase, non-receptor type 1	8735	0.17
chr9_116228629_116228809	0.11	Gm31410	predicted gene, 31410	9917	0.19
chr7_24316221_24316527	0.11	Zfp94	zinc finger protein 94	208	0.82
chr7_44589314_44589478	0.11	Gm15396	predicted gene 15396	1228	0.19
chr15_90679035_90679205	0.11	Cpne8	copine VIII	251	0.93
chr1_181465127_181465294	0.11	Gm16539	predicted gene 16539	32810	0.14
chr2_31505484_31505674	0.11	Ass1	argininosuccinate synthetase 1	4853	0.2
chr11_109502246_109502399	0.11	Gm22378	predicted gene, 22378	2498	0.21
chr13_93640508_93640869	0.11	Bhmt	betaine-homocysteine methyltransferase	2727	0.21
chr10_69190805_69191022	0.10	Rhobtb1	Rho-related BTB domain containing 1	17639	0.16
chr2_117018527_117018695	0.10	Gm13981	predicted gene 13981	36955	0.14
chr2_59979903_59980091	0.10	Gm13574	predicted gene 13574	12347	0.19
chr10_42205235_42205454	0.10	Foxo3	forkhead box O3	53022	0.15
chr14_25741793_25741944	0.10	Zcchc24	zinc finger, CCHC domain containing 24	22076	0.13
chr4_118476510_118476661	0.10	Tie1	tyrosine kinase with immunoglobulin-like and EGF-like domains 1	13170	0.1
chr19_47305501_47305661	0.10	Sh3pxd2a	SH3 and PX domains 2A	9170	0.17
chr15_78852145_78852296	0.10	Lgals2	lectin, galactose-binding, soluble 2	3309	0.11

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of Tbx5

View svg image
View png image

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	0.6	GO:0010046	response to mycotoxin(GO:0010046)
0.0	0.1	GO:0043152	induction of bacterial agglutination(GO:0043152)
0.0	0.3	GO:0006776	vitamin A metabolic process(GO:0006776)
0.0	0.1	GO:2000828	regulation of parathyroid hormone secretion(GO:2000828)
0.0	0.1	GO:1903800	positive regulation of production of miRNAs involved in gene silencing by miRNA(GO:1903800)
0.0	0.1	GO:0006362	transcription elongation from RNA polymerase I promoter(GO:0006362)
0.0	0.1	GO:0021847	ventricular zone neuroblast division(GO:0021847)
0.0	0.2	GO:0006563	L-serine metabolic process(GO:0006563)
0.0	0.1	GO:1903297	regulation of hypoxia-induced intrinsic apoptotic signaling pathway(GO:1903297) negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway(GO:1903298)
0.0	0.1	GO:0030951	establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951)
0.0	0.1	GO:0003099	positive regulation of the force of heart contraction by epinephrine-norepinephrine(GO:0001997) positive regulation of the force of heart contraction by chemical signal(GO:0003099)
0.0	0.1	GO:0007039	protein catabolic process in the vacuole(GO:0007039)
0.0	0.1	GO:0010908	regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010908) positive regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010909) positive regulation of proteoglycan biosynthetic process(GO:1902730)
0.0	0.1	GO:0010735	positive regulation of transcription via serum response element binding(GO:0010735)
0.0	0.1	GO:0006982	response to lipid hydroperoxide(GO:0006982)
0.0	0.1	GO:0060137	maternal process involved in parturition(GO:0060137)
0.0	0.1	GO:1901844	regulation of cell communication by electrical coupling involved in cardiac conduction(GO:1901844)
0.0	0.1	GO:1904504	regulation of lipophagy(GO:1904502) positive regulation of lipophagy(GO:1904504)
0.0	0.1	GO:0000379	tRNA-type intron splice site recognition and cleavage(GO:0000379)
0.0	0.1	GO:0048669	collateral sprouting in absence of injury(GO:0048669)
0.0	0.0	GO:2000646	positive regulation of receptor catabolic process(GO:2000646)
0.0	0.0	GO:1904154	positive regulation of retrograde protein transport, ER to cytosol(GO:1904154)
0.0	0.1	GO:0033353	S-adenosylmethionine cycle(GO:0033353)
0.0	0.1	GO:1990086	lens fiber cell apoptotic process(GO:1990086)
0.0	0.0	GO:1902996	neurofibrillary tangle assembly(GO:1902988) regulation of neurofibrillary tangle assembly(GO:1902996)
0.0	0.1	GO:0010963	regulation of L-arginine import(GO:0010963)
0.0	0.0	GO:0035964	COPI-coated vesicle budding(GO:0035964)
0.0	0.2	GO:0045647	negative regulation of erythrocyte differentiation(GO:0045647)
0.0	0.1	GO:0061043	regulation of vascular wound healing(GO:0061043)
0.0	0.1	GO:0070973	protein localization to endoplasmic reticulum exit site(GO:0070973)
0.0	0.1	GO:0006548	histidine catabolic process(GO:0006548) imidazole-containing compound catabolic process(GO:0052805)
0.0	0.0	GO:2000468	regulation of peroxidase activity(GO:2000468)
0.0	0.1	GO:1903525	regulation of membrane tubulation(GO:1903525)
0.0	0.1	GO:0032489	regulation of Cdc42 protein signal transduction(GO:0032489)
0.0	0.1	GO:0051791	medium-chain fatty acid metabolic process(GO:0051791)
0.0	0.1	GO:1901301	regulation of cargo loading into COPII-coated vesicle(GO:1901301)
0.0	0.2	GO:0010310	regulation of hydrogen peroxide metabolic process(GO:0010310)
0.0	0.1	GO:0007175	negative regulation of epidermal growth factor-activated receptor activity(GO:0007175)
0.0	0.1	GO:0060528	secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development(GO:0060528)
0.0	0.1	GO:0034756	regulation of iron ion transport(GO:0034756)
0.0	0.1	GO:0072675	osteoclast fusion(GO:0072675)
0.0	0.0	GO:0097460	ferrous iron import into cell(GO:0097460)
0.0	0.0	GO:0003223	ventricular compact myocardium morphogenesis(GO:0003223)
0.0	0.1	GO:1903025	regulation of RNA polymerase II regulatory region sequence-specific DNA binding(GO:1903025)
0.0	0.1	GO:2000619	negative regulation of histone H4-K16 acetylation(GO:2000619)
0.0	0.0	GO:0046684	response to pyrethroid(GO:0046684)
0.0	0.1	GO:1904469	positive regulation of tumor necrosis factor secretion(GO:1904469)
0.0	0.1	GO:1901524	regulation of macromitophagy(GO:1901524) negative regulation of macromitophagy(GO:1901525)
0.0	0.0	GO:0006556	S-adenosylmethionine biosynthetic process(GO:0006556)
0.0	0.0	GO:0030242	pexophagy(GO:0030242)
0.0	0.0	GO:0060468	prevention of polyspermy(GO:0060468)
0.0	0.0	GO:0045472	response to ether(GO:0045472)
0.0	0.0	GO:0071879	positive regulation of adrenergic receptor signaling pathway(GO:0071879)
0.0	0.0	GO:2000823	regulation of androgen receptor activity(GO:2000823)
0.0	0.0	GO:0016095	polyprenol catabolic process(GO:0016095)
0.0	0.1	GO:0006526	arginine biosynthetic process(GO:0006526)
0.0	0.0	GO:0048936	peripheral nervous system neuron axonogenesis(GO:0048936)
0.0	0.1	GO:0035999	tetrahydrofolate interconversion(GO:0035999)
0.0	0.1	GO:0034625	fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.0	0.1	GO:0009957	epidermal cell fate specification(GO:0009957)
0.0	0.1	GO:0019401	alditol biosynthetic process(GO:0019401)
0.0	0.0	GO:0009256	10-formyltetrahydrofolate metabolic process(GO:0009256)
0.0	0.0	GO:0021943	formation of radial glial scaffolds(GO:0021943)
0.0	0.1	GO:0060283	negative regulation of oocyte development(GO:0060283)
0.0	0.0	GO:0050427	3'-phosphoadenosine 5'-phosphosulfate metabolic process(GO:0050427)
0.0	0.0	GO:0002669	positive regulation of T cell anergy(GO:0002669) positive regulation of lymphocyte anergy(GO:0002913)
0.0	0.0	GO:0002432	granuloma formation(GO:0002432)
0.0	0.0	GO:0006987	activation of signaling protein activity involved in unfolded protein response(GO:0006987)
0.0	0.1	GO:0044539	long-chain fatty acid import(GO:0044539)
0.0	0.1	GO:0060334	regulation of interferon-gamma-mediated signaling pathway(GO:0060334)
0.0	0.0	GO:0021699	cerebellar cortex maturation(GO:0021699)
0.0	0.0	GO:0046104	thymidine metabolic process(GO:0046104)
0.0	0.1	GO:0002317	plasma cell differentiation(GO:0002317)
0.0	0.1	GO:0032534	regulation of microvillus assembly(GO:0032534)
0.0	0.0	GO:0010510	regulation of acetyl-CoA biosynthetic process from pyruvate(GO:0010510) regulation of acyl-CoA biosynthetic process(GO:0050812)
0.0	0.1	GO:2000189	positive regulation of cholesterol homeostasis(GO:2000189)
0.0	0.0	GO:0008228	opsonization(GO:0008228)
0.0	0.0	GO:0090309	positive regulation of methylation-dependent chromatin silencing(GO:0090309)
0.0	0.0	GO:0051081	membrane disassembly(GO:0030397) nuclear envelope disassembly(GO:0051081)
0.0	0.1	GO:0010793	regulation of mRNA export from nucleus(GO:0010793) regulation of ribonucleoprotein complex localization(GO:2000197)
0.0	0.0	GO:0071930	negative regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0071930)
0.0	0.0	GO:0070368	positive regulation of hepatocyte differentiation(GO:0070368)
0.0	0.0	GO:0010792	DNA double-strand break processing involved in repair via single-strand annealing(GO:0010792)
0.0	0.0	GO:0007525	somatic muscle development(GO:0007525)
0.0	0.0	GO:1990928	response to amino acid starvation(GO:1990928)
0.0	0.0	GO:1903275	positive regulation of sodium ion export(GO:1903275) positive regulation of sodium ion export from cell(GO:1903278)
0.0	0.0	GO:0060800	regulation of cell differentiation involved in embryonic placenta development(GO:0060800)
0.0	0.0	GO:0018094	protein polyglycylation(GO:0018094)
0.0	0.0	GO:0071947	protein deubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0071947)
0.0	0.1	GO:1903798	regulation of production of miRNAs involved in gene silencing by miRNA(GO:1903798)
0.0	0.1	GO:1990845	diet induced thermogenesis(GO:0002024) adaptive thermogenesis(GO:1990845)
0.0	0.1	GO:0016255	attachment of GPI anchor to protein(GO:0016255)
0.0	0.0	GO:0021912	regulation of transcription from RNA polymerase II promoter involved in spinal cord motor neuron fate specification(GO:0021912)
0.0	0.1	GO:0051775	response to redox state(GO:0051775)
0.0	0.0	GO:0030091	protein repair(GO:0030091)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.6	GO:0070852	cell body fiber(GO:0070852)
0.0	0.1	GO:0097487	multivesicular body, internal vesicle(GO:0097487)
0.0	0.1	GO:1990357	terminal web(GO:1990357)
0.0	0.1	GO:0097057	TRAF2-GSTP1 complex(GO:0097057)
0.0	0.1	GO:0097451	glial limiting end-foot(GO:0097451)
0.0	0.2	GO:0005577	fibrinogen complex(GO:0005577)
0.0	0.1	GO:0035339	SPOTS complex(GO:0035339)
0.0	0.0	GO:0097441	basilar dendrite(GO:0097441)
0.0	0.1	GO:0031084	BLOC-2 complex(GO:0031084)
0.0	0.1	GO:0097255	R2TP complex(GO:0097255)
0.0	0.1	GO:0005579	membrane attack complex(GO:0005579)
0.0	0.2	GO:0043020	NADPH oxidase complex(GO:0043020)
0.0	0.0	GO:0097443	sorting endosome(GO:0097443)
0.0	0.1	GO:0000214	tRNA-intron endonuclease complex(GO:0000214)
0.0	0.1	GO:0034366	spherical high-density lipoprotein particle(GO:0034366)
0.0	0.1	GO:0031258	lamellipodium membrane(GO:0031258)
0.0	0.1	GO:0042627	chylomicron(GO:0042627)
0.0	0.0	GO:0060053	neurofilament cytoskeleton(GO:0060053)
0.0	0.0	GO:0071942	XPC complex(GO:0071942)
0.0	0.0	GO:0035867	alphav-beta3 integrin-IGF-1-IGF1R complex(GO:0035867)
0.0	0.1	GO:0042765	GPI-anchor transamidase complex(GO:0042765)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.2	GO:0003941	L-serine ammonia-lyase activity(GO:0003941)
0.0	0.6	GO:0015643	toxic substance binding(GO:0015643)
0.0	0.1	GO:0048408	epidermal growth factor binding(GO:0048408)
0.0	0.2	GO:0016176	superoxide-generating NADPH oxidase activator activity(GO:0016176)
0.0	0.1	GO:0016802	adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.0	0.1	GO:0031852	mu-type opioid receptor binding(GO:0031852)
0.0	0.2	GO:0043731	3-(3-hydroxyphenyl)propionate hydroxylase activity(GO:0008688) 4-chlorobenzaldehyde oxidase activity(GO:0018471) 3,5-xylenol methylhydroxylase activity(GO:0018630) phenylacetate hydroxylase activity(GO:0018631) 4-nitrophenol 4-monooxygenase activity(GO:0018632) dimethyl sulfide monooxygenase activity(GO:0018633) alpha-pinene monooxygenase [NADH] activity(GO:0018634) 1-hydroxy-2-naphthoate hydroxylase activity(GO:0018637) toluene 4-monooxygenase activity(GO:0018638) xylene monooxygenase activity(GO:0018639) dibenzothiophene monooxygenase activity(GO:0018640) 6-hydroxy-3-methyl-2-oxo-1,2-dihydroquinoline 6-monooxygenase activity(GO:0018641) chlorophenol 4-monooxygenase activity(GO:0018642) carbon disulfide oxygenase activity(GO:0018643) toluene 2-monooxygenase activity(GO:0018644) 1-hydroxy-2-oxolimonene 1,2-monooxygenase activity(GO:0018646) phenanthrene 1,2-monooxygenase activity(GO:0018647) tetrahydrofuran hydroxylase activity(GO:0018649) styrene monooxygenase activity(GO:0018650) toluene-4-sulfonate monooxygenase activity(GO:0018651) toluene-sulfonate methyl-monooxygenase activity(GO:0018652) 3-methyl-2-oxo-1,2-dihydroquinoline 6-monooxygenase activity(GO:0018653) 2-hydroxy-phenylacetate hydroxylase activity(GO:0018654) 2-oxo-delta3-4,5,5-trimethylcyclopentenylacetyl-CoA 1,2-monooxygenase activity(GO:0018655) phenanthrene 3,4-monooxygenase activity(GO:0018656) toluene 3-monooxygenase activity(GO:0018657) 4-hydroxyphenylacetate,NADH:oxygen oxidoreductase (3-hydroxylating) activity(GO:0018660) limonene monooxygenase activity(GO:0019113) 2-methylnaphthalene hydroxylase activity(GO:0034526) 1-methylnaphthalene hydroxylase activity(GO:0034534) bisphenol A hydroxylase A activity(GO:0034560) salicylate 5-hydroxylase activity(GO:0034785) isobutylamine N-hydroxylase activity(GO:0034791) branched-chain dodecylbenzene sulfonate monooxygenase activity(GO:0034802) 3-HSA hydroxylase activity(GO:0034819) 4-hydroxypyridine-3-hydroxylase activity(GO:0034894) 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase activity(GO:0043719) 6-hydroxynicotinate 3-monooxygenase activity(GO:0043731) thalianol hydroxylase activity(GO:0080014)
0.0	0.1	GO:0004937	alpha1-adrenergic receptor activity(GO:0004937)
0.0	0.1	GO:0016401	palmitoyl-CoA oxidase activity(GO:0016401)
0.0	0.1	GO:0005119	smoothened binding(GO:0005119)
0.0	0.0	GO:0016841	ammonia-lyase activity(GO:0016841)
0.0	0.1	GO:0070644	vitamin D response element binding(GO:0070644)
0.0	0.1	GO:0016743	carboxyl- or carbamoyltransferase activity(GO:0016743)
0.0	0.1	GO:0017162	aryl hydrocarbon receptor binding(GO:0017162)
0.0	0.1	GO:0008430	selenium binding(GO:0008430)
0.0	0.1	GO:0004022	alcohol dehydrogenase (NAD) activity(GO:0004022)
0.0	0.2	GO:0019841	retinol binding(GO:0019841)
0.0	0.1	GO:0097493	structural molecule activity conferring elasticity(GO:0097493)
0.0	0.1	GO:0000213	tRNA-intron endonuclease activity(GO:0000213)
0.0	0.0	GO:0000253	3-keto sterol reductase activity(GO:0000253)
0.0	0.1	GO:0031849	olfactory receptor binding(GO:0031849)
0.0	0.1	GO:0030550	acetylcholine receptor inhibitor activity(GO:0030550)
0.0	0.0	GO:0004103	choline kinase activity(GO:0004103)
0.0	0.0	GO:0031800	type 3 metabotropic glutamate receptor binding(GO:0031800)
0.0	0.1	GO:0019957	C-C chemokine binding(GO:0019957)
0.0	0.0	GO:0004611	phosphoenolpyruvate carboxykinase activity(GO:0004611)
0.0	0.1	GO:0047105	aminobutyraldehyde dehydrogenase activity(GO:0019145) 4-trimethylammoniobutyraldehyde dehydrogenase activity(GO:0047105)
0.0	0.0	GO:0035373	chondroitin sulfate proteoglycan binding(GO:0035373)
0.0	0.1	GO:0004758	serine C-palmitoyltransferase activity(GO:0004758)
0.0	0.1	GO:0034714	type III transforming growth factor beta receptor binding(GO:0034714)
0.0	0.1	GO:0030976	thiamine pyrophosphate binding(GO:0030976)
0.0	0.1	GO:0031779	melanocortin receptor binding(GO:0031779) type 3 melanocortin receptor binding(GO:0031781) type 4 melanocortin receptor binding(GO:0031782)
0.0	0.0	GO:0034191	apolipoprotein A-I receptor binding(GO:0034191)
0.0	0.0	GO:0008900	hydrogen:potassium-exchanging ATPase activity(GO:0008900)
0.0	0.1	GO:0102336	fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)
0.0	0.0	GO:0008898	S-adenosylmethionine-homocysteine S-methyltransferase activity(GO:0008898)
0.0	0.1	GO:0001163	RNA polymerase I regulatory region sequence-specific DNA binding(GO:0001163) RNA polymerase I CORE element sequence-specific DNA binding(GO:0001164)
0.0	0.0	GO:0004470	malic enzyme activity(GO:0004470) malate dehydrogenase (decarboxylating) (NAD+) activity(GO:0004471)
0.0	0.2	GO:1900750	glutathione binding(GO:0043295) oligopeptide binding(GO:1900750)
0.0	0.0	GO:0035276	ethanol binding(GO:0035276)
0.0	0.0	GO:0001875	lipopolysaccharide receptor activity(GO:0001875)
0.0	0.0	GO:0016822	hydrolase activity, acting on acid carbon-carbon bonds(GO:0016822) hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances(GO:0016823)
0.0	0.0	GO:0047751	3-oxo-5-alpha-steroid 4-dehydrogenase activity(GO:0003865) cholestenone 5-alpha-reductase activity(GO:0047751)
0.0	0.0	GO:0030943	mitochondrion targeting sequence binding(GO:0030943)
0.0	0.0	GO:0000293	ferric-chelate reductase activity(GO:0000293)
0.0	0.0	GO:0004833	tryptophan 2,3-dioxygenase activity(GO:0004833)
0.0	0.1	GO:0046934	phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934)
0.0	0.0	GO:0004740	pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740)
0.0	0.1	GO:0004176	ATP-dependent peptidase activity(GO:0004176)
0.0	0.1	GO:1990459	transferrin receptor binding(GO:1990459)
0.0	0.1	GO:0070290	N-acylphosphatidylethanolamine-specific phospholipase D activity(GO:0070290)
0.0	0.0	GO:0043423	3-phosphoinositide-dependent protein kinase binding(GO:0043423)
0.0	0.1	GO:0070513	death domain binding(GO:0070513)
0.0	0.1	GO:0042500	aspartic endopeptidase activity, intramembrane cleaving(GO:0042500)
0.0	0.0	GO:0003726	double-stranded RNA adenosine deaminase activity(GO:0003726)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.4	PID RETINOIC ACID PATHWAY	Retinoic acid receptors-mediated signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Total log-likelihood	Term	Description
0.0	REACTOME RORA ACTIVATES CIRCADIAN EXPRESSION	Genes involved in RORA Activates Circadian Expression
0.1	REACTOME RNA POL I PROMOTER OPENING	Genes involved in RNA Polymerase I Promoter Opening
0.1	REACTOME COMMON PATHWAY	Genes involved in Common Pathway