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ENCSR904DTN: DNase-seq of mouse liver in constant darkness

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for Tcf3

Z-value: 1.36

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Transcription factors associated with Tcf3

Gene Symbol	Gene ID	Gene Info
Tcf3 Ensembl NCBI MGI UniProt	ENSMUSG00000020167.8	Tcf3

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

Gene	Promoter	Distance	Association probability	Pearson corr. coef.	P-value	Plot
Tcf3	chr10_80423960_80424130	2185	0.140379	-0.98	6.2e-04	Click!
Tcf3	chr10_80444503_80444654	10931	0.085381	-0.74	9.3e-02	Click!
Tcf3	chr10_80433536_80433845	43	0.943195	-0.69	1.3e-01	Click!
Tcf3	chr10_80446179_80446497	12691	0.083839	-0.66	1.5e-01	Click!
Tcf3	chr10_80435895_80436307	2454	0.136501	-0.64	1.7e-01	Click!

Activity of the Tcf3 motif across conditions

Conditions sorted by the z-value of the Tcf3 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr11_19851376_19851638	1.43	Gm12029	predicted gene 12029	67855	0.1
chr3_89147086_89147561	0.73	Hcn3	hyperpolarization-activated, cyclic nucleotide-gated K+ 3	3891	0.08
chr12_104087488_104087669	0.57	Serpina4-ps1	serine (or cysteine) peptidase inhibitor, clade A, member 4, pseudogene 1	6929	0.1
chr10_111318102_111318256	0.56	Gm40761	predicted gene, 40761	18945	0.17
chr10_91261198_91261441	0.52	Gm18705	predicted gene, 18705	1975	0.31
chr15_3468356_3468528	0.51	Ghr	growth hormone receptor	3202	0.36
chr9_74366017_74366190	0.47	Nr1h2-ps	nuclear receptor subfamily 1, group H, member 2, pseudogene	1040	0.56
chr19_18146304_18146531	0.44	Gm18610	predicted gene, 18610	59378	0.14
chr4_10854377_10854556	0.43	Gm12919	predicted gene 12919	623	0.61
chr15_3513860_3514011	0.42	Ghr	growth hormone receptor	42291	0.19
chr16_5140582_5140765	0.42	Sec14l5	SEC14-like lipid binding 5	6436	0.13
chr9_122850000_122850173	0.42	Gm47140	predicted gene, 47140	1668	0.22
chr19_20723027_20723214	0.41	Aldh1a7	aldehyde dehydrogenase family 1, subfamily A7	4442	0.3
chr8_66494561_66494830	0.39	Gm32568	predicted gene, 32568	364	0.85
chr11_16816577_16816728	0.38	Egfros	epidermal growth factor receptor, opposite strand	14050	0.21
chr11_120819185_120819682	0.38	Fasn	fatty acid synthase	3978	0.11
chr7_24919736_24919914	0.37	Arhgef1	Rho guanine nucleotide exchange factor (GEF) 1	623	0.53
chr2_58769900_58770051	0.36	Upp2	uridine phosphorylase 2	4650	0.24
chr17_10093572_10093736	0.36	Qk	quaking	119920	0.06
chr13_58192282_58192443	0.35	Gm48357	predicted gene, 48357	1044	0.37
chr2_152359606_152359999	0.35	Gm14165	predicted gene 14165	6187	0.1
chr11_5904597_5904748	0.35	Gck	glucokinase	2585	0.17
chr11_16868479_16868644	0.34	Egfr	epidermal growth factor receptor	9589	0.2
chr11_16858660_16858826	0.33	Egfr	epidermal growth factor receptor	19407	0.18
chr13_19246519_19246807	0.33	Trgc3	T cell receptor gamma, constant 3	14221	0.22
chr8_93180612_93180763	0.32	Ces1d	carboxylesterase 1D	5398	0.15
chr9_122848440_122848788	0.31	Gm47140	predicted gene, 47140	196	0.89
chr4_117831574_117831756	0.31	Slc6a9	solute carrier family 6 (neurotransmitter transporter, glycine), member 9	2841	0.16
chr5_130303522_130303878	0.31	Tyw1	tRNA-yW synthesizing protein 1 homolog (S. cerevisiae)	44770	0.1
chr11_106412764_106412932	0.31	Icam2	intercellular adhesion molecule 2	24773	0.12
chr1_50806470_50806812	0.31	Gm28321	predicted gene 28321	8734	0.28
chr11_22372894_22373087	0.31	Rpsa-ps3	ribosomal protein SA, pseudogene 3	13302	0.21
chr6_37347891_37348042	0.30	Creb3l2	cAMP responsive element binding protein 3-like 2	11431	0.26
chr8_120046709_120046884	0.30	Gm15684	predicted gene 15684	1509	0.32
chr1_59202432_59202591	0.29	Als2	alsin Rho guanine nucleotide exchange factor	16615	0.14
chr11_16833397_16833632	0.29	Egfros	epidermal growth factor receptor, opposite strand	2812	0.3
chr10_111314954_111315105	0.29	Bbs10	Bardet-Biedl syndrome 10 (human)	16350	0.18
chr2_49177399_49177550	0.28	Gm13510	predicted gene 13510	7544	0.27
chr16_49907450_49907601	0.28	Cd47	CD47 antigen (Rh-related antigen, integrin-associated signal transducer)	40692	0.2
chr19_57506666_57506817	0.28	6720468P15Rik	RIKEN cDNA 6720468P15 gene	1823	0.28
chr12_30372401_30372579	0.28	Sntg2	syntrophin, gamma 2	775	0.73
chr3_87801773_87801942	0.28	Insrr	insulin receptor-related receptor	86	0.95
chr15_58960813_58961185	0.28	Mtss1	MTSS I-BAR domain containing 1	4159	0.17
chr2_101762531_101762726	0.28	Prr5l	proline rich 5 like	35022	0.17
chr13_113844856_113845031	0.28	Arl15	ADP-ribosylation factor-like 15	50321	0.11
chr1_9578333_9578671	0.27	Gm6161	predicted gene 6161	3954	0.16
chr11_70083308_70083461	0.27	Asgr2	asialoglycoprotein receptor 2	9260	0.09
chr1_164426310_164426497	0.27	Gm37411	predicted gene, 37411	1690	0.31
chr15_85233381_85233563	0.27	Fbln1	fibulin 1	27467	0.17
chr12_108292499_108292690	0.27	Hhipl1	hedgehog interacting protein-like 1	13676	0.15
chr5_113141351_113141509	0.26	4930557B06Rik	RIKEN cDNA 4930557B06 gene	1019	0.36
chr4_102511795_102511975	0.26	Pde4b	phosphodiesterase 4B, cAMP specific	41488	0.21
chr6_55108463_55108627	0.26	Crhr2	corticotropin releasing hormone receptor 2	7972	0.19
chr2_167292312_167292496	0.26	Gm11473	predicted gene 11473	10627	0.16
chr15_75047474_75047625	0.26	Ly6c1	lymphocyte antigen 6 complex, locus C1	1120	0.32
chr11_51494380_51494743	0.25	Col23a1	collagen, type XXIII, alpha 1	79871	0.07
chr5_24502879_24503079	0.25	Agap3	ArfGAP with GTPase domain, ankyrin repeat and PH domain 3	22807	0.08
chr16_11098511_11098684	0.25	Txndc11	thioredoxin domain containing 11	11245	0.1
chr10_86872197_86872354	0.25	Stab2	stabilin 2	6683	0.14
chr2_17326719_17326870	0.25	Nebl	nebulette	34292	0.22
chr15_58993520_58993677	0.25	4930544F09Rik	RIKEN cDNA 4930544F09 gene	9462	0.17
chr11_22893094_22893344	0.25	Gm24917	predicted gene, 24917	24318	0.11
chr18_8328204_8328355	0.25	Gm5500	predicted pseudogene 5500	86850	0.09
chr4_49553429_49553778	0.24	Aldob	aldolase B, fructose-bisphosphate	4057	0.17
chr8_46385009_46385281	0.24	Gm45253	predicted gene 45253	743	0.6
chr10_69208384_69208535	0.24	Rhobtb1	Rho-related BTB domain containing 1	93	0.97
chr11_110499189_110499340	0.24	Map2k6	mitogen-activated protein kinase kinase 6	20225	0.24
chr11_98770698_98771034	0.23	Nr1d1	nuclear receptor subfamily 1, group D, member 1	440	0.69
chr7_15939282_15939433	0.23	Snord23	small nucleolar RNA, C/D box 23	487	0.65
chr8_36548724_36548879	0.23	Dlc1	deleted in liver cancer 1	28468	0.19
chr18_80261215_80262161	0.23	Slc66a2	solute carrier family 66 member 2	1152	0.35
chr19_46632420_46632695	0.23	Wbp1l	WW domain binding protein 1 like	9156	0.13
chr5_130042317_130042468	0.23	Crcp	calcitonin gene-related peptide-receptor component protein	188	0.92
chr9_108401502_108401859	0.23	1700102P08Rik	RIKEN cDNA 1700102P08 gene	8846	0.07
chr12_85299100_85299299	0.23	Zc2hc1c	zinc finger, C2HC-type containing 1C	10608	0.1
chr15_98738867_98739043	0.22	Fkbp11	FK506 binding protein 11	10757	0.09
chr2_121193827_121193979	0.22	Tubgcp4	tubulin, gamma complex associated protein 4	1956	0.22
chr17_78241487_78241665	0.21	Crim1	cysteine rich transmembrane BMP regulator 1 (chordin like)	3804	0.22
chr8_77012726_77012888	0.21	Nr3c2	nuclear receptor subfamily 3, group C, member 2	104535	0.06
chr5_88367022_88367405	0.21	Amtn	amelotin	8895	0.17
chr4_118002076_118002227	0.21	9530034E10Rik	RIKEN cDNA 9530034E10 gene	27115	0.13
chr5_81910056_81910231	0.21	2900064F13Rik	RIKEN cDNA 2900064F13 gene	83327	0.09
chr18_64006042_64006212	0.21	Gm6974	predicted gene 6974	75293	0.09
chr2_20939712_20939881	0.21	Arhgap21	Rho GTPase activating protein 21	3623	0.24
chr18_67579213_67579374	0.21	Gm17669	predicted gene, 17669	16899	0.16
chr7_4647276_4647517	0.21	Ppp6r1	protein phosphatase 6, regulatory subunit 1	9	0.94
chr17_24674148_24674299	0.20	Zfp598	zinc finger protein 598	2919	0.09
chr11_16818044_16818409	0.20	Egfros	epidermal growth factor receptor, opposite strand	12476	0.22
chr18_84376572_84376752	0.20	Gm37216	predicted gene, 37216	516	0.84
chr11_120248567_120248734	0.20	Bahcc1	BAH domain and coiled-coil containing 1	11951	0.09
chr2_52372456_52372665	0.20	Neb	nebulin	5030	0.17
chr11_16798191_16798439	0.20	Egfros	epidermal growth factor receptor, opposite strand	32387	0.16
chr10_81378463_81379124	0.20	Fzr1	fizzy and cell division cycle 20 related 1	277	0.71
chr14_67917259_67917426	0.20	Dock5	dedicator of cytokinesis 5	16090	0.22
chr13_4270977_4271134	0.20	Akr1c12	aldo-keto reductase family 1, member C12	8378	0.15
chr13_69631727_69631878	0.20	Nsun2	NOL1/NOP2/Sun domain family member 2	1062	0.36
chr12_105005460_105005678	0.20	Syne3	spectrin repeat containing, nuclear envelope family member 3	4240	0.13
chr6_43272880_43273031	0.20	Arhgef5	Rho guanine nucleotide exchange factor (GEF) 5	1556	0.25
chr9_107649361_107649537	0.19	Slc38a3	solute carrier family 38, member 3	6571	0.08
chr4_53086731_53086906	0.19	Abca1	ATP-binding cassette, sub-family A (ABC1), member 1	45892	0.13
chr10_4120834_4121002	0.19	Gm25515	predicted gene, 25515	16605	0.2
chr14_78548923_78549074	0.19	Akap11	A kinase (PRKA) anchor protein 11	12190	0.2
chr7_75611829_75612100	0.19	Akap13	A kinase (PRKA) anchor protein 13	124	0.97
chr15_59020453_59020630	0.19	Mtss1	MTSS I-BAR domain containing 1	20055	0.17
chr13_96660106_96660425	0.19	Hmgcr	3-hydroxy-3-methylglutaryl-Coenzyme A reductase	3598	0.18
chr4_49538717_49538957	0.19	Aldob	aldolase B, fructose-bisphosphate	29	0.97
chr2_172938722_172938940	0.19	Bmp7	bone morphogenetic protein 7	1261	0.45
chr3_75868999_75869188	0.19	Golim4	golgi integral membrane protein 4	9915	0.24
chr18_76254679_76254860	0.19	Smad2	SMAD family member 2	6352	0.2
chr6_38823949_38824290	0.19	Hipk2	homeodomain interacting protein kinase 2	5773	0.25
chr19_37433970_37434137	0.19	Gm38345	predicted gene, 38345	603	0.45
chr17_80697982_80698359	0.19	Map4k3	mitogen-activated protein kinase kinase kinase kinase 3	29854	0.18
chr5_23462026_23462363	0.19	Kmt2e	lysine (K)-specific methyltransferase 2E	16361	0.15
chr15_9079456_9079615	0.18	Nadk2	NAD kinase 2, mitochondrial	4258	0.25
chr16_10366678_10366849	0.18	Gm1600	predicted gene 1600	19172	0.14
chr14_24960151_24960328	0.18	Gm10398	predicted gene 10398	50825	0.13
chr11_16769921_16770266	0.18	Egfr	epidermal growth factor receptor	17863	0.19
chr7_31101720_31101871	0.18	Hpn	hepsin	719	0.46
chr2_32409058_32409478	0.18	Gm13413	predicted gene 13413	3213	0.12
chr12_103670437_103670601	0.18	Serpina16	serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 16	4945	0.12
chr1_126484684_126484835	0.18	Nckap5	NCK-associated protein 5	7983	0.32
chr2_127367630_127367825	0.18	Adra2b	adrenergic receptor, alpha 2b	4441	0.16
chr4_130708524_130708794	0.18	Snord85	small nucleolar RNA, C/D box 85	40975	0.1
chr9_57214145_57214320	0.18	Trcg1	taste receptor cell gene 1	22324	0.12
chr16_30664084_30664254	0.18	Fam43a	family with sequence similarity 43, member A	64446	0.1
chr1_62809972_62810173	0.18	Gm37121	predicted gene, 37121	770	0.67
chr12_32707351_32707528	0.18	Gm18726	predicted gene, 18726	2722	0.31
chr2_134826467_134826626	0.17	Gm14036	predicted gene 14036	22597	0.2
chr3_24630236_24630408	0.17	Gm24704	predicted gene, 24704	68248	0.14
chr6_84235021_84235302	0.17	Gm44127	predicted gene, 44127	9909	0.22
chr15_99101408_99101603	0.17	Dnajc22	DnaJ heat shock protein family (Hsp40) member C22	2093	0.16
chr8_111739071_111739223	0.17	Bcar1	breast cancer anti-estrogen resistance 1	4662	0.21
chr4_86373682_86373833	0.17	Gm12550	predicted gene 12550	68584	0.11
chr15_10206547_10206755	0.17	Prlr	prolactin receptor	6814	0.3
chr2_174330237_174330577	0.17	Gnas	GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus	120	0.95
chr2_124609977_124610547	0.17	Sema6d	sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D	34	0.99
chr8_26078485_26078636	0.17	Hook3	hook microtubule tethering protein 3	817	0.46
chr15_76227819_76227970	0.17	Plec	plectin	1603	0.17
chr13_108042230_108042425	0.17	Smim15	small integral membrane protein 15	2119	0.37
chr9_67137735_67137898	0.17	Gm19299	predicted gene, 19299	4255	0.21
chr11_59226278_59226466	0.17	Arf1	ADP-ribosylation factor 1	1790	0.2
chr16_26669940_26670091	0.17	Il1rap	interleukin 1 receptor accessory protein	45859	0.18
chr7_68728361_68728534	0.16	Gm44692	predicted gene 44692	1980	0.37
chr5_135703012_135703168	0.16	Gm16061	predicted gene 16061	4071	0.13
chr5_36176782_36177189	0.16	Psapl1	prosaposin-like 1	27036	0.21
chr4_139454119_139454298	0.16	Ubr4	ubiquitin protein ligase E3 component n-recognin 4	9051	0.18
chr6_38870157_38870322	0.16	Tbxas1	thromboxane A synthase 1, platelet	5165	0.22
chr19_9027860_9028087	0.16	Ahnak	AHNAK nucleoprotein (desmoyokin)	28313	0.09
chr17_35865754_35865905	0.16	Ppp1r18	protein phosphatase 1, regulatory subunit 18	204	0.76
chr8_11145382_11145560	0.16	Gm44717	predicted gene 44717	3775	0.2
chr14_25508473_25508633	0.16	Zmiz1	zinc finger, MIZ-type containing 1	5898	0.16
chr1_130387327_130387514	0.16	Cd55b	CD55 molecule, decay accelerating factor for complement B	35320	0.11
chr15_59014305_59014721	0.16	Mtss1	MTSS I-BAR domain containing 1	26083	0.16
chr3_107230665_107230816	0.16	A630076J17Rik	RIKEN cDNA A630076J17 gene	126	0.94
chr5_51144711_51144875	0.16	Gm44377	predicted gene, 44377	78881	0.1
chr7_79308613_79308815	0.16	Gm39041	predicted gene, 39041	9689	0.14
chr6_51573063_51573238	0.16	Snx10	sorting nexin 10	28584	0.17
chr15_89102253_89102404	0.16	Tubgcp6	tubulin, gamma complex associated protein 6	44	0.94
chr15_55843743_55843894	0.16	Sntb1	syntrophin, basic 1	62492	0.11
chr6_136906748_136907166	0.16	Erp27	endoplasmic reticulum protein 27	15183	0.11
chr14_67884776_67884962	0.16	Mir6539	microRNA 6539	25124	0.2
chr3_129557154_129557334	0.16	Elovl6	ELOVL family member 6, elongation of long chain fatty acids (yeast)	4864	0.19
chr14_16478758_16478933	0.16	Top2b	topoisomerase (DNA) II beta	53417	0.13
chr15_83772573_83772737	0.15	Mpped1	metallophosphoesterase domain containing 1	6812	0.24
chr17_47593664_47594464	0.15	Ccnd3	cyclin D3	249	0.86
chr12_110221880_110222031	0.15	Gm40576	predicted gene, 40576	14407	0.11
chr11_117233984_117234135	0.15	Septin9	septin 9	1774	0.34
chr11_50104096_50104296	0.15	Rnf130	ring finger protein 130	10522	0.12
chr11_6016490_6016658	0.15	Camk2b	calcium/calmodulin-dependent protein kinase II, beta	16126	0.16
chr5_138948306_138948628	0.15	Pdgfa	platelet derived growth factor, alpha	45814	0.12
chr19_48703871_48704022	0.15	Sorcs3	sortilin-related VPS10 domain containing receptor 3	270	0.95
chr16_92637112_92637263	0.15	Gm26626	predicted gene, 26626	24373	0.19
chr13_9199577_9199754	0.15	Gm8784	predicted gene 8784	23872	0.13
chr8_71495277_71495471	0.15	Gtpbp3	GTP binding protein 3	5915	0.08
chr5_134209731_134209889	0.15	Gtf2ird2	GTF2I repeat domain containing 2	3153	0.17
chr14_60976604_60976847	0.15	Tnfrsf19	tumor necrosis factor receptor superfamily, member 19	840	0.7
chr10_68103006_68103157	0.15	Arid5b	AT rich interactive domain 5B (MRF1-like)	33545	0.18
chr3_138280557_138280953	0.15	Adh1	alcohol dehydrogenase 1 (class I)	3104	0.16
chr10_11306105_11306256	0.15	Gm48666	predicted gene, 48666	24235	0.12
chr16_95851988_95852139	0.15	1600002D24Rik	RIKEN cDNA 1600002D24 gene	6293	0.2
chr10_117884880_117885031	0.15	Gm32552	predicted gene, 32552	18240	0.14
chr7_137286258_137286429	0.15	Ebf3	early B cell factor 3	18805	0.18
chr1_73513962_73514123	0.15	Gm9553	predicted gene 9553	1996	0.31
chr1_67197545_67197701	0.15	Gm15668	predicted gene 15668	51577	0.13
chr6_67036040_67036201	0.15	E230016M11Rik	RIKEN cDNA E230016M11 gene	479	0.61
chr7_99165012_99165417	0.15	Dgat2	diacylglycerol O-acyltransferase 2	4892	0.14
chr2_18159543_18159694	0.14	Gm25147	predicted gene, 25147	931	0.48
chr11_22494745_22494936	0.14	Gm12051	predicted gene 12051	11232	0.19
chr19_53786299_53786461	0.14	Rbm20	RNA binding motif protein 20	6928	0.18
chr6_139624876_139625027	0.14	Pik3c2g	phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma	3063	0.3
chr15_64362676_64362949	0.14	Asap1	ArfGAP with SH3 domain, ankyrin repeat and PH domain1	12926	0.19
chr19_29862924_29863094	0.14	Gm50380	predicted gene, 50380	12208	0.18
chr6_101046905_101047082	0.14	Gm43948	predicted gene, 43948	12178	0.18
chr7_119523427_119523676	0.14	Pdilt	protein disulfide isomerase-like, testis expressed	62	0.95
chr3_41498956_41499107	0.14	Platr4	pluripotency associated transcript 4	5839	0.14
chr10_69257688_69257866	0.14	Rhobtb1	Rho-related BTB domain containing 1	7860	0.2
chr12_103805644_103805795	0.14	Gm17043	predicted gene 17043	1357	0.28
chr2_27767443_27767901	0.14	Rxra	retinoid X receptor alpha	27471	0.21
chr1_181529523_181529674	0.14	Ccdc121	coiled-coil domain containing 121	18147	0.19
chr1_157101218_157101391	0.14	Tex35	testis expressed 35	7084	0.18

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of Tcf3

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:1903800	positive regulation of production of miRNAs involved in gene silencing by miRNA(GO:1903800)
0.1	0.3	GO:0010446	response to alkaline pH(GO:0010446)
0.1	0.2	GO:1900169	regulation of glucocorticoid mediated signaling pathway(GO:1900169)
0.1	0.2	GO:0061624	fructose catabolic process(GO:0006001) fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate(GO:0061624) glycolytic process through fructose-1-phosphate(GO:0061625)
0.1	0.2	GO:2001013	epithelial cell proliferation involved in renal tubule morphogenesis(GO:2001013)
0.1	0.2	GO:2000828	regulation of parathyroid hormone secretion(GO:2000828)
0.0	0.2	GO:0090435	protein localization to nuclear envelope(GO:0090435)
0.0	0.1	GO:0006549	isoleucine metabolic process(GO:0006549)
0.0	0.2	GO:0006384	transcription initiation from RNA polymerase III promoter(GO:0006384)
0.0	0.1	GO:0061368	behavioral response to chemical pain(GO:0061366) behavioral response to formalin induced pain(GO:0061368)
0.0	0.1	GO:1901187	regulation of ephrin receptor signaling pathway(GO:1901187)
0.0	0.2	GO:0051418	interphase microtubule nucleation by interphase microtubule organizing center(GO:0051415) microtubule nucleation by microtubule organizing center(GO:0051418)
0.0	0.1	GO:0071895	odontoblast differentiation(GO:0071895)
0.0	0.1	GO:1900104	hyaluranon cable assembly(GO:0036118) regulation of hyaluranon cable assembly(GO:1900104) positive regulation of hyaluranon cable assembly(GO:1900106)
0.0	0.1	GO:0010693	negative regulation of alkaline phosphatase activity(GO:0010693)
0.0	0.1	GO:1904263	positive regulation of TORC1 signaling(GO:1904263)
0.0	0.1	GO:2000670	positive regulation of dendritic cell apoptotic process(GO:2000670)
0.0	0.2	GO:0010871	negative regulation of receptor biosynthetic process(GO:0010871)
0.0	0.1	GO:0009732	detection of carbohydrate stimulus(GO:0009730) detection of hexose stimulus(GO:0009732) detection of monosaccharide stimulus(GO:0034287) detection of glucose(GO:0051594)
0.0	0.0	GO:0070672	response to interleukin-15(GO:0070672)
0.0	0.1	GO:0042271	susceptibility to natural killer cell mediated cytotoxicity(GO:0042271)
0.0	0.0	GO:0038161	prolactin signaling pathway(GO:0038161)
0.0	0.1	GO:0015817	histidine transport(GO:0015817)
0.0	0.1	GO:2000623	regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000622) negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000623)
0.0	0.1	GO:0008295	spermidine biosynthetic process(GO:0008295)
0.0	0.1	GO:0044027	hypermethylation of CpG island(GO:0044027)
0.0	0.1	GO:0018401	peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401)
0.0	0.1	GO:0050882	voluntary musculoskeletal movement(GO:0050882)
0.0	0.1	GO:0032289	central nervous system myelin formation(GO:0032289)
0.0	0.1	GO:0051684	maintenance of Golgi location(GO:0051684)
0.0	0.1	GO:0031145	anaphase-promoting complex-dependent catabolic process(GO:0031145)
0.0	0.1	GO:0090038	negative regulation of protein kinase C signaling(GO:0090038)
0.0	0.1	GO:0034196	acylglycerol transport(GO:0034196) triglyceride transport(GO:0034197)
0.0	0.1	GO:1902683	regulation of receptor localization to synapse(GO:1902683)
0.0	0.1	GO:0019626	short-chain fatty acid catabolic process(GO:0019626)
0.0	0.1	GO:0044805	lysosomal microautophagy(GO:0016237) piecemeal microautophagy of nucleus(GO:0034727) late nucleophagy(GO:0044805)
0.0	0.1	GO:0006741	NADP biosynthetic process(GO:0006741)
0.0	0.1	GO:1901078	negative regulation of relaxation of muscle(GO:1901078)
0.0	0.1	GO:0018125	peptidyl-cysteine methylation(GO:0018125)
0.0	0.2	GO:1900452	regulation of long term synaptic depression(GO:1900452)
0.0	0.1	GO:0030421	defecation(GO:0030421)
0.0	0.1	GO:0007296	vitellogenesis(GO:0007296)
0.0	0.1	GO:0006526	arginine biosynthetic process(GO:0006526)
0.0	0.1	GO:0034454	microtubule anchoring at centrosome(GO:0034454)
0.0	0.0	GO:1904154	positive regulation of retrograde protein transport, ER to cytosol(GO:1904154)
0.0	0.1	GO:0042866	pyruvate biosynthetic process(GO:0042866)
0.0	0.1	GO:0090080	positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway(GO:0090080)
0.0	0.0	GO:1903286	regulation of potassium ion import(GO:1903286) positive regulation of potassium ion import(GO:1903288)
0.0	0.1	GO:1902004	positive regulation of beta-amyloid formation(GO:1902004) positive regulation of amyloid precursor protein catabolic process(GO:1902993)
0.0	0.1	GO:2000574	regulation of microtubule motor activity(GO:2000574)
0.0	0.1	GO:0006651	diacylglycerol biosynthetic process(GO:0006651)
0.0	0.1	GO:0033159	negative regulation of protein import into nucleus, translocation(GO:0033159)
0.0	0.0	GO:0038044	transforming growth factor-beta secretion(GO:0038044) regulation of transforming growth factor-beta secretion(GO:2001201)
0.0	0.0	GO:0061010	gall bladder development(GO:0061010)
0.0	0.2	GO:0030213	hyaluronan biosynthetic process(GO:0030213)
0.0	0.1	GO:0051295	establishment of meiotic spindle localization(GO:0051295)
0.0	0.0	GO:0019676	ammonia assimilation cycle(GO:0019676)
0.0	0.0	GO:0035694	mitochondrial protein catabolic process(GO:0035694)
0.0	0.0	GO:0070175	positive regulation of enamel mineralization(GO:0070175)
0.0	0.0	GO:0006982	response to lipid hydroperoxide(GO:0006982)
0.0	0.1	GO:0010739	positive regulation of protein kinase A signaling(GO:0010739)
0.0	0.2	GO:0043517	positive regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043517)
0.0	0.0	GO:0010909	regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010908) positive regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010909) positive regulation of proteoglycan biosynthetic process(GO:1902730)
0.0	0.0	GO:0030578	PML body organization(GO:0030578)
0.0	0.1	GO:0046855	inositol phosphate dephosphorylation(GO:0046855)
0.0	0.0	GO:0032489	regulation of Cdc42 protein signal transduction(GO:0032489)
0.0	0.0	GO:0006068	ethanol catabolic process(GO:0006068)
0.0	0.0	GO:0034140	negative regulation of toll-like receptor 3 signaling pathway(GO:0034140)
0.0	0.1	GO:0051131	chaperone-mediated protein complex assembly(GO:0051131)
0.0	0.0	GO:0048320	axial mesoderm formation(GO:0048320)
0.0	0.0	GO:0072095	regulation of branch elongation involved in ureteric bud branching(GO:0072095)
0.0	0.0	GO:0035793	cell migration involved in metanephros development(GO:0035788) metanephric mesenchymal cell migration(GO:0035789) positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway(GO:0035793) regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway(GO:1900238) regulation of metanephric mesenchymal cell migration(GO:2000589) positive regulation of metanephric mesenchymal cell migration(GO:2000591)
0.0	0.0	GO:0050427	3'-phosphoadenosine 5'-phosphosulfate metabolic process(GO:0050427)
0.0	0.1	GO:0051547	regulation of keratinocyte migration(GO:0051547) positive regulation of keratinocyte migration(GO:0051549)
0.0	0.0	GO:0002408	myeloid dendritic cell chemotaxis(GO:0002408)
0.0	0.0	GO:0072053	renal inner medulla development(GO:0072053)
0.0	0.0	GO:1904694	negative regulation of vascular smooth muscle contraction(GO:1904694)
0.0	0.0	GO:0008228	opsonization(GO:0008228)
0.0	0.1	GO:0007182	common-partner SMAD protein phosphorylation(GO:0007182)
0.0	0.1	GO:0040034	regulation of development, heterochronic(GO:0040034)
0.0	0.0	GO:0090427	activation of meiosis(GO:0090427)
0.0	0.0	GO:0070447	positive regulation of oligodendrocyte progenitor proliferation(GO:0070447)
0.0	0.0	GO:0032058	positive regulation of translational initiation in response to stress(GO:0032058)
0.0	0.2	GO:0014912	negative regulation of smooth muscle cell migration(GO:0014912)
0.0	0.0	GO:0010528	regulation of transposition(GO:0010528) negative regulation of transposition(GO:0010529)
0.0	0.1	GO:0036233	glycine import(GO:0036233)
0.0	0.0	GO:0001994	norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure(GO:0001994)
0.0	0.0	GO:0006083	acetate metabolic process(GO:0006083)
0.0	0.0	GO:0002331	pre-B cell allelic exclusion(GO:0002331)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.2	GO:0008274	gamma-tubulin large complex(GO:0000931) gamma-tubulin ring complex(GO:0008274)
0.1	0.2	GO:0030868	smooth endoplasmic reticulum membrane(GO:0030868) smooth endoplasmic reticulum part(GO:0097425)
0.0	0.2	GO:0031983	vesicle lumen(GO:0031983)
0.0	0.1	GO:0070939	Dsl1p complex(GO:0070939)
0.0	0.1	GO:0032541	cortical endoplasmic reticulum(GO:0032541)
0.0	0.1	GO:0031417	NatC complex(GO:0031417)
0.0	0.1	GO:0097433	dense body(GO:0097433)
0.0	0.2	GO:0042575	DNA polymerase complex(GO:0042575)
0.0	0.1	GO:0097512	cardiac myofibril(GO:0097512)
0.0	0.1	GO:0045098	type III intermediate filament(GO:0045098)
0.0	0.1	GO:0044316	cone cell pedicle(GO:0044316)
0.0	0.2	GO:0031932	TORC2 complex(GO:0031932)
0.0	0.1	GO:0016222	procollagen-proline 4-dioxygenase complex(GO:0016222)
0.0	0.0	GO:0071664	catenin-TCF7L2 complex(GO:0071664)
0.0	0.0	GO:0000923	equatorial microtubule organizing center(GO:0000923)
0.0	0.0	GO:0032444	activin responsive factor complex(GO:0032444)
0.0	0.1	GO:0031094	platelet dense tubular network(GO:0031094)
0.0	0.1	GO:0042788	polysomal ribosome(GO:0042788)
0.0	0.0	GO:0005899	insulin receptor complex(GO:0005899)
0.0	0.1	GO:0000220	vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220)
0.0	0.0	GO:0097418	neurofibrillary tangle(GO:0097418)
0.0	0.1	GO:0070695	FHF complex(GO:0070695)
0.0	0.0	GO:0002189	ribose phosphate diphosphokinase complex(GO:0002189)
0.0	0.0	GO:0071953	elastic fiber(GO:0071953)
0.0	0.0	GO:0097441	basilar dendrite(GO:0097441)
0.0	0.2	GO:0032588	trans-Golgi network membrane(GO:0032588)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:0048408	epidermal growth factor binding(GO:0048408)
0.1	0.2	GO:0097109	neuroligin family protein binding(GO:0097109)
0.1	0.2	GO:0004332	fructose-bisphosphate aldolase activity(GO:0004332)
0.0	0.2	GO:0097642	calcitonin family receptor activity(GO:0097642)
0.0	0.2	GO:0005173	stem cell factor receptor binding(GO:0005173)
0.0	0.2	GO:0051430	corticotropin-releasing hormone receptor 1 binding(GO:0051430)
0.0	0.1	GO:0031697	beta-1 adrenergic receptor binding(GO:0031697)
0.0	0.1	GO:0018479	benzaldehyde dehydrogenase (NAD+) activity(GO:0018479)
0.0	0.1	GO:0070053	thrombospondin receptor activity(GO:0070053)
0.0	0.1	GO:0051718	DNA (cytosine-5-)-methyltransferase activity(GO:0003886) DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates(GO:0051718)
0.0	0.1	GO:0010997	anaphase-promoting complex binding(GO:0010997)
0.0	0.3	GO:0043560	insulin receptor substrate binding(GO:0043560)
0.0	0.1	GO:0003846	2-acylglycerol O-acyltransferase activity(GO:0003846)
0.0	0.2	GO:0051011	microtubule minus-end binding(GO:0051011)
0.0	0.1	GO:0015182	L-asparagine transmembrane transporter activity(GO:0015182) L-glutamine transmembrane transporter activity(GO:0015186)
0.0	0.1	GO:0005030	neurotrophin receptor activity(GO:0005030)
0.0	0.1	GO:0003941	L-serine ammonia-lyase activity(GO:0003941)
0.0	0.2	GO:0005078	MAP-kinase scaffold activity(GO:0005078)
0.0	0.1	GO:0001515	opioid peptide activity(GO:0001515)
0.0	0.1	GO:0016743	carboxyl- or carbamoyltransferase activity(GO:0016743)
0.0	0.0	GO:0004030	aldehyde dehydrogenase [NAD(P)+] activity(GO:0004030)
0.0	0.1	GO:0031545	peptidyl-proline 4-dioxygenase activity(GO:0031545)
0.0	0.1	GO:0016901	oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor(GO:0016901)
0.0	0.1	GO:0032190	acrosin binding(GO:0032190)
0.0	0.0	GO:0004771	sterol esterase activity(GO:0004771)
0.0	0.0	GO:0034186	apolipoprotein A-I binding(GO:0034186)
0.0	0.0	GO:0031686	A1 adenosine receptor binding(GO:0031686)
0.0	0.0	GO:0072345	NAADP-sensitive calcium-release channel activity(GO:0072345)
0.0	0.0	GO:0038181	bile acid receptor activity(GO:0038181)
0.0	0.1	GO:0015375	glycine:sodium symporter activity(GO:0015375)
0.0	0.1	GO:0004396	glucokinase activity(GO:0004340) hexokinase activity(GO:0004396)
0.0	0.1	GO:0008190	eukaryotic initiation factor 4E binding(GO:0008190)
0.0	0.0	GO:0016971	flavin-linked sulfhydryl oxidase activity(GO:0016971) thiol oxidase activity(GO:0016972)
0.0	0.0	GO:0005168	neurotrophin TRKA receptor binding(GO:0005168)
0.0	0.1	GO:0004028	3-chloroallyl aldehyde dehydrogenase activity(GO:0004028)
0.0	0.1	GO:0070700	BMP receptor binding(GO:0070700)
0.0	0.0	GO:0004024	alcohol dehydrogenase activity, zinc-dependent(GO:0004024)
0.0	0.1	GO:1990247	N6-methyladenosine-containing RNA binding(GO:1990247)
0.0	0.0	GO:0005220	inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.0	0.0	GO:0004749	ribose phosphate diphosphokinase activity(GO:0004749)
0.0	0.2	GO:0003785	actin monomer binding(GO:0003785)
0.0	0.1	GO:0008467	[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity(GO:0008467)
0.0	0.0	GO:0070051	fibrinogen binding(GO:0070051)
0.0	0.0	GO:2001070	starch binding(GO:2001070)
0.0	0.0	GO:0070644	vitamin D response element binding(GO:0070644)
0.0	0.0	GO:0051377	mannose-ethanolamine phosphotransferase activity(GO:0051377)
0.0	0.1	GO:0001671	ATPase activator activity(GO:0001671)
0.0	0.2	GO:0016864	protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864)

Gene overrepresentation in curated gene sets: canonical pathways category:

Total log-likelihood	Term	Description
0.3	PID SYNDECAN 3 PATHWAY	Syndecan-3-mediated signaling events
0.1	SA G2 AND M PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.5	PID RHOA REG PATHWAY	Regulation of RhoA activity

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Total log-likelihood	Term	Description
0.2	REACTOME RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES	Genes involved in Recruitment of NuMA to mitotic centrosomes
0.3	REACTOME SHC1 EVENTS IN EGFR SIGNALING	Genes involved in SHC1 events in EGFR signaling
0.1	REACTOME SIGNALLING TO P38 VIA RIT AND RIN	Genes involved in Signalling to p38 via RIT and RIN
0.2	REACTOME PROLACTIN RECEPTOR SIGNALING	Genes involved in Prolactin receptor signaling
0.2	REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI	Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.1	REACTOME INHIBITION OF INSULIN SECRETION BY ADRENALINE NORADRENALINE	Genes involved in Inhibition of Insulin Secretion by Adrenaline/Noradrenaline
0.2	REACTOME PROSTACYCLIN SIGNALLING THROUGH PROSTACYCLIN RECEPTOR	Genes involved in Prostacyclin signalling through prostacyclin receptor
0.0	REACTOME G BETA GAMMA SIGNALLING THROUGH PLC BETA	Genes involved in G beta:gamma signalling through PLC beta