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ENCSR904DTN: DNase-seq of mouse liver in constant darkness
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Results for Tfap2b

Z-value: 1.52

Motif logo

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Transcription factors associated with Tfap2b

Gene Symbol Gene ID Gene Info
Tfap2b
ENSMUSG00000025927.7 transcription factor AP-2 beta

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE Gene Distance Association probability Pearson corr. coef. P-value Plot
chr1_19205686_19205886Tfap2b31280.260115-0.872.2e-02Click!

Activity of the Tfap2b motif across conditions

Conditions sorted by the z-value of the Tfap2b motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE) Target Score Top associated gene Gene Info Distance of CRE to TSS CRE/Gene association probability
chr8_45333523_45333723 1.19 Cyp4v3
 cytochrome P450, family 4, subfamily v, polypeptide 3
 407
 0.81
chr12_108856815_108857551 1.15 Gm22079
 predicted gene, 22079
 5486
 0.1
chr7_102025342_102025783 1.13 Rnf121
 ring finger protein 121
 1093
 0.33
chr2_181413297_181413448 1.13 Zbtb46
 zinc finger and BTB domain containing 46
 11016
 0.1
chr2_167831188_167831379 1.09 1200007C13Rik
 RIKEN cDNA 1200007C13 gene
 2363
 0.25
chr1_89669764_89670114 1.08 4933400F21Rik
 RIKEN cDNA 4933400F21 gene
 13949
 0.24
chr9_107688467_107688630 1.06 Sema3f
 sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F
 1231
 0.26
chr9_50874153_50874482 1.06 Ppp2r1b
 protein phosphatase 2, regulatory subunit A, beta
 1305
 0.4
chr10_85829643_85829823 1.01 Gm19624
 predicted gene, 19624
 9
 0.75
chr4_57320936_57321111 0.93 Ptpn3
 protein tyrosine phosphatase, non-receptor type 3
 19186
 0.15
chr10_63373532_63373708 0.88 Sirt1
 sirtuin 1
 8084
 0.13
chr6_128102357_128102567 0.86 Gm26338
 predicted gene, 26338
 7436
 0.15
chr1_179836517_179836707 0.84 Ahctf1
 AT hook containing transcription factor 1
 32932
 0.16
chr16_22699066_22699230 0.83 Gm8118
 predicted gene 8118
 12954
 0.18
chr11_119936702_119936872 0.82 Gm11766
 predicted gene 11766
 1724
 0.24
chr7_45213806_45213957 0.82 Dkkl1
 dickkopf-like 1
 1734
 0.12
chr7_143313622_143313928 0.81 Gm37364
 predicted gene, 37364
 16077
 0.12
chr8_120622299_120622462 0.78 1190005I06Rik
 RIKEN cDNA 1190005I06 gene
 11983
 0.09
chr5_110431894_110432052 0.77 Fbrsl1
 fibrosin-like 1
 1348
 0.35
chr2_179292597_179292961 0.75 Gm14293
 predicted gene 14293
 52289
 0.14
chr2_69911096_69911271 0.75 Ubr3
 ubiquitin protein ligase E3 component n-recognin 3
 13880
 0.13
chr10_86685801_86686017 0.75 1810014B01Rik
 RIKEN cDNA 1810014B01 gene
 20
 0.93
chr1_133877032_133877215 0.75 Optc
 opticin
 24204
 0.12
chr1_167387431_167387591 0.75 Mgst3
 microsomal glutathione S-transferase 3
 6330
 0.16
chr2_149759276_149759438 0.74 Gm14130
 predicted gene 14130
 16182
 0.2
chr6_112883814_112883983 0.73 Srgap3
 SLIT-ROBO Rho GTPase activating protein 3
 54439
 0.1
chr11_55406169_55406386 0.71 Sparc
 secreted acidic cysteine rich glycoprotein
 4112
 0.19
chr7_19228252_19228443 0.70 Opa3
 optic atrophy 3
 13
 0.94
chr12_76710114_76710283 0.68 Sptb
 spectrin beta, erythrocytic
 175
 0.95
chr7_28969689_28969854 0.67 Eif3k
 eukaryotic translation initiation factor 3, subunit K
 5065
 0.11
chr16_4912876_4913042 0.67 Mgrn1
 mahogunin, ring finger 1
 252
 0.86
chr9_43467006_43467175 0.67 Gm28215
 predicted gene 28215
 2332
 0.29
chr11_101369464_101369615 0.65 G6pc
 glucose-6-phosphatase, catalytic
 1978
 0.11
chr1_165629214_165629365 0.65 Mpzl1
 myelin protein zero-like 1
 4797
 0.13
chr1_153990768_153990949 0.64 Gm29291
 predicted gene 29291
 15359
 0.15
chr4_148448716_148449227 0.63 Mtor
 mechanistic target of rapamycin kinase
 346
 0.82
chr19_3850863_3851029 0.62 Chka
 choline kinase alpha
 827
 0.37
chr10_39174337_39174497 0.62 D030034A15Rik
 RIKEN cDNA D030034A15 gene
 1165
 0.4
chr7_49178293_49178474 0.62 Gm37613
 predicted gene, 37613
 17158
 0.18
chr17_29394251_29394433 0.62 Fgd2
 FYVE, RhoGEF and PH domain containing 2
 17841
 0.11
chr14_51100561_51100914 0.61 Rnase4
 ribonuclease, RNase A family 4
 4378
 0.09
chr10_96377652_96377803 0.61 Gm20091
 predicted gene, 20091
 31311
 0.14
chr13_32066979_32067135 0.60 Gm48885
 predicted gene, 48885
 32118
 0.21
chr11_50292381_50292544 0.59 Maml1
 mastermind like transcriptional coactivator 1
 151
 0.93
chr8_120437914_120438125 0.58 Gm22715
 predicted gene, 22715
 5530
 0.21
chr5_104399237_104399791 0.58 Spp1
 secreted phosphoprotein 1
 35604
 0.12
chr1_165461123_165461290 0.57 Mpc2
 mitochondrial pyruvate carrier 2
 18
 0.92
chr9_59539398_59539715 0.56 Hexa
 hexosaminidase A
 16
 0.8
chr5_139818915_139819083 0.56 Tmem184a
 transmembrane protein 184a
 918
 0.45
chr18_31910656_31910818 0.55 Sft2d3
 SFT2 domain containing 3
 1087
 0.41
chr17_32241257_32241435 0.55 Gm4432
 predicted gene 4432
 817
 0.53
chr16_22163049_22163219 0.54 Igf2bp2
 insulin-like growth factor 2 mRNA binding protein 2
 115
 0.96
chr11_45877769_45877933 0.54 Clint1
 clathrin interactor 1
 4546
 0.19
chr5_135187024_135187335 0.53 Baz1b
 bromodomain adjacent to zinc finger domain, 1B
 85
 0.95
chr12_111121851_111122115 0.52 Gm48632
 predicted gene, 48632
 30783
 0.12
chr15_102243536_102243699 0.52 Rarg
 retinoic acid receptor, gamma
 28
 0.95
chr8_119419822_119419973 0.51 Osgin1
 oxidative stress induced growth inhibitor 1
 14227
 0.14
chr13_54249070_54249391 0.51 Gm48615
 predicted gene, 48615
 3934
 0.19
chr6_125088559_125088736 0.51 2010008C14Rik
 RIKEN cDNA 2010008C14 gene
 5210
 0.08
chr2_124858722_124858893 0.51 Gm13994
 predicted gene 13994
 150152
 0.04
chr1_191946290_191946441 0.50 Rd3
 retinal degeneration 3
 31005
 0.1
chr16_91822408_91822590 0.50 Itsn1
 intersectin 1 (SH3 domain protein 1A)
 5038
 0.2
chr10_75596123_75596274 0.50 Gm9985
 predicted gene 9985
 5545
 0.11
chr12_85151515_85151693 0.50 Rps6kl1
 ribosomal protein S6 kinase-like 1
 340
 0.8
chr10_127659568_127659719 0.49 Stat6
 signal transducer and activator of transcription 6
 243
 0.82
chr5_43032061_43032271 0.49 Gm43700
 predicted gene 43700
 6070
 0.19
chr7_19572974_19573173 0.49 Gemin7
 gem nuclear organelle associated protein 7
 16
 0.95
chr7_18957606_18957786 0.48 Nanos2
 nanos C2HC-type zinc finger 2
 29704
 0.06
chr8_128491169_128491342 0.48 Nrp1
 neuropilin 1
 131858
 0.05
chr11_100515071_100515366 0.48 Acly
 ATP citrate lyase
 8380
 0.1
chr6_43292582_43293012 0.48 Arhgef5
 Rho guanine nucleotide exchange factor (GEF) 5
 9915
 0.12
chr4_118247695_118247892 0.47 Ptprf
 protein tyrosine phosphatase, receptor type, F
 11348
 0.17
chr10_75121130_75121291 0.47 Bcr
 BCR activator of RhoGEF and GTPase
 39150
 0.15
chr16_30525931_30526082 0.47 Tmem44
 transmembrane protein 44
 14903
 0.19
chr7_30347923_30348110 0.46 4930479H17Rik
 RIKEN cDNA 4930479H17 gene
 5305
 0.07
chr6_118593826_118593977 0.46 Cacna1c
 calcium channel, voltage-dependent, L type, alpha 1C subunit
 1525
 0.4
chr19_9954439_9954606 0.46 Gm50346
 predicted gene, 50346
 11690
 0.09
chr3_81036630_81036817 0.45 Pdgfc
 platelet-derived growth factor, C polypeptide
 307
 0.87
chr2_165969012_165969173 0.44 Gm11462
 predicted gene 11462
 9303
 0.13
chr14_14345872_14346046 0.44 Il3ra
 interleukin 3 receptor, alpha chain
 316
 0.78
chr13_95554131_95554549 0.44 Gm48730
 predicted gene, 48730
 18750
 0.14
chr4_134061289_134061592 0.43 Crybg2
 crystallin beta-gamma domain containing 2
 625
 0.58
chr10_126979601_126979791 0.43 Ctdsp2
 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2
 667
 0.48
chr10_77144461_77144617 0.43 Gm7775
 predicted gene 7775
 7439
 0.19
chr8_120538960_120539167 0.43 Mir7687
 microRNA 7687
 367
 0.7
chr7_113242447_113242773 0.42 Arntl
 aryl hydrocarbon receptor nuclear translocator-like
 2856
 0.29
chr5_112283643_112283806 0.42 Tpst2
 protein-tyrosine sulfotransferase 2
 5038
 0.13
chr18_80236503_80236751 0.41 Hsbp1l1
 heat shock factor binding protein 1-like 1
 206
 0.89
chr14_70520498_70520830 0.41 Bmp1
 bone morphogenetic protein 1
 430
 0.67
chr9_54516094_54516256 0.41 Dmxl2
 Dmx-like 2
 14549
 0.17
chr7_44858584_44858824 0.41 Pnkp
 polynucleotide kinase 3'- phosphatase
 208
 0.82
chr2_11365489_11365685 0.41 Gm37730
 predicted gene, 37730
 1864
 0.2
chr6_128803059_128803375 0.41 Klrb1c
 killer cell lectin-like receptor subfamily B member 1C
 14002
 0.09
chr19_46003413_46003585 0.41 Hps6
 HPS6, biogenesis of lysosomal organelles complex 2 subunit 3
 9
 0.96
chr12_80001998_80002169 0.40 Gm8275
 predicted gene 8275
 22232
 0.17
chr2_155099563_155099720 0.40 2310005A03Rik
 RIKEN cDNA 2310005A03 gene
 440
 0.77
chr6_29272524_29272714 0.40 Hilpda
 hypoxia inducible lipid droplet associated
 7
 0.96
chr3_101599885_101600061 0.39 Gm42941
 predicted gene 42941
 2843
 0.23
chr2_167842569_167842745 0.39 1200007C13Rik
 RIKEN cDNA 1200007C13 gene
 9011
 0.16
chr7_46835248_46835408 0.39 Gm45308
 predicted gene 45308
 2864
 0.13
chr2_119742132_119742303 0.39 Itpka
 inositol 1,4,5-trisphosphate 3-kinase A
 120
 0.91
chr9_90113472_90114008 0.39 Morf4l1
 mortality factor 4 like 1
 549
 0.72
chr11_118211857_118212019 0.39 Cyth1
 cytohesin 1
 804
 0.57
chr17_43327081_43327253 0.39 Adgrf5
 adhesion G protein-coupled receptor F5
 33284
 0.19
chr14_30011884_30012221 0.38 Chdh
 choline dehydrogenase
 2881
 0.15
chr11_96863519_96863691 0.38 Gm11524
 predicted gene 11524
 6590
 0.09
chr11_106491531_106491682 0.38 Ern1
 endoplasmic reticulum (ER) to nucleus signalling 1
 3754
 0.18
chr4_106980690_106980853 0.38 Ssbp3
 single-stranded DNA binding protein 3
 14345
 0.18
chr19_3877298_3877449 0.38 Chka
 choline kinase alpha
 1968
 0.16
chr4_150065927_150066095 0.38 Mir34a
 microRNA 34a
 2443
 0.16
chr4_123299380_123299675 0.38 Pabpc4
 poly(A) binding protein, cytoplasmic 4
 2347
 0.15
chr5_105826898_105827072 0.38 Lrrc8d
 leucine rich repeat containing 8D
 2474
 0.21
chr11_101928490_101928696 0.38 Rpl27-ps2
 ribosomal protein L27, pseudogene 2
 10908
 0.1
chr11_44405875_44406089 0.38 Il12b
 interleukin 12b
 5919
 0.19
chr7_99699741_99699908 0.37 Slco2b1
 solute carrier organic anion transporter family, member 2b1
 4015
 0.12
chr8_119445523_119446899 0.37 Necab2
 N-terminal EF-hand calcium binding protein 2
 508
 0.74
chr1_86586776_86586949 0.37 Cops7b
 COP9 signalosome subunit 7B
 238
 0.88
chr19_42551158_42551329 0.36 Gm16541
 predicted gene 16541
 11852
 0.18
chr14_61360115_61360286 0.36 Ebpl
 emopamil binding protein-like
 120
 0.94
chr8_124275783_124275948 0.36 Galnt2
 polypeptide N-acetylgalactosaminyltransferase 2
 19238
 0.16
chr1_88959907_88960074 0.36 Gm4753
 predicted gene 4753
 27671
 0.17
chr4_137769010_137769180 0.36 Alpl
 alkaline phosphatase, liver/bone/kidney
 520
 0.8
chr10_84757574_84757782 0.35 Rfx4
 regulatory factor X, 4 (influences HLA class II expression)
 1616
 0.43
chr5_110797818_110798001 0.35 Ulk1
 unc-51 like kinase 1
 2075
 0.19
chr16_32246842_32247035 0.35 Fbxo45
 F-box protein 45
 220
 0.55
chr17_17345622_17345809 0.35 Oaz1-ps
 ornithine decarboxylase antizyme 1, pseudogene
 425
 0.8
chr9_31279892_31280066 0.35 Prdm10
 PR domain containing 10
 559
 0.59
chr4_137824947_137825262 0.34 Alpl
 alkaline phosphatase, liver/bone/kidney
 28720
 0.16
chr9_40628453_40628756 0.34 Gm48284
 predicted gene, 48284
 12218
 0.12
chr7_110942267_110942426 0.34 Mrvi1
 MRV integration site 1
 3841
 0.23
chr10_40124800_40124982 0.34 Gm25613
 predicted gene, 25613
 15429
 0.13
chr12_108832369_108832526 0.34 Slc25a29
 solute carrier family 25 (mitochondrial carrier, palmitoylcarnitine transporter), member 29
 830
 0.42
chr6_54070751_54070926 0.34 Chn2
 chimerin 2
 26882
 0.18
chr15_83518459_83518650 0.34 Gm24575
 predicted gene, 24575
 1618
 0.25
chr9_57785755_57786023 0.34 Arid3b
 AT rich interactive domain 3B (BRIGHT-like)
 5759
 0.16
chr1_93370316_93370486 0.34 Ano7
 anoctamin 7
 3529
 0.12
chr7_140835414_140835584 0.33 Urah
 urate (5-hydroxyiso-) hydrolase
 125
 0.89
chr16_29944225_29944722 0.33 Gm26569
 predicted gene, 26569
 2043
 0.31
chr16_78377023_78377174 0.33 Btg3
 BTG anti-proliferation factor 3
 94
 0.97
chr8_70221071_70221246 0.33 Armc6
 armadillo repeat containing 6
 1132
 0.32
chr7_83636527_83636716 0.33 Gm45838
 predicted gene 45838
 3250
 0.14
chr2_132721307_132721479 0.33 Gm22245
 predicted gene, 22245
 4287
 0.14
chr2_167634494_167634653 0.33 Ube2v1
 ubiquitin-conjugating enzyme E2 variant 1
 2478
 0.16
chr3_85887151_85887500 0.32 Gm37240
 predicted gene, 37240
 43
 0.62
chr6_31399464_31399657 0.32 Mkln1
 muskelin 1, intracellular mediator containing kelch motifs
 701
 0.44
chr2_119355713_119355881 0.32 Chac1
 ChaC, cation transport regulator 1
 4568
 0.16
chr11_120189789_120189958 0.32 2810410L24Rik
 RIKEN cDNA 2810410L24 gene
 21
 0.96
chr7_141818371_141818522 0.32 Muc5b
 mucin 5, subtype B, tracheobronchial
 20624
 0.14
chr11_97819881_97820206 0.31 Lasp1
 LIM and SH3 protein 1
 4795
 0.1
chr6_99521816_99522204 0.31 Foxp1
 forkhead box P1
 637
 0.76
chr9_106447373_106447582 0.31 Abhd14b
 abhydrolase domain containing 14b
 18
 0.49
chr3_94690762_94690922 0.31 Selenbp2
 selenium binding protein 2
 2714
 0.16
chr5_92110928_92111278 0.31 Gm24931
 predicted gene, 24931
 7180
 0.13
chr4_3938729_3938917 0.31 Chchd7
 coiled-coil-helix-coiled-coil-helix domain containing 7
 65
 0.84
chr15_86169783_86169988 0.31 Cerk
 ceramide kinase
 10417
 0.17
chr13_31223115_31223275 0.30 4930401O12Rik
 RIKEN cDNA 4930401O12 gene
 17891
 0.19
chr1_165768492_165768643 0.30 Creg1
 cellular repressor of E1A-stimulated genes 1
 909
 0.37
chr6_121879272_121879452 0.30 Mug1
 murinoglobulin 1
 6215
 0.21
chr18_80704875_80705052 0.30 Gm50211
 predicted gene, 50211
 227
 0.92
chr1_61649997_61650160 0.30 Gm37205
 predicted gene, 37205
 4345
 0.17
chr3_10284943_10285269 0.30 Fabp12
 fatty acid binding protein 12
 16068
 0.09
chr1_119648939_119649109 0.30 Epb41l5
 erythrocyte membrane protein band 4.1 like 5
 24
 0.97
chrX_159988087_159988260 0.30 Map3k15
 mitogen-activated protein kinase kinase kinase 15
 260
 0.92
chr8_84656944_84657116 0.29 Ier2
 immediate early response 2
 5824
 0.11
chr16_11006083_11006392 0.29 Gm24961
 predicted gene, 24961
 11851
 0.1
chr16_95679759_95679918 0.29 Ets2
 E26 avian leukemia oncogene 2, 3' domain
 22237
 0.2
chr1_87803823_87803974 0.29 Sag
 S-antigen, retina and pineal gland (arrestin)
 218
 0.9
chr5_51511559_51511740 0.29 Gm43605
 predicted gene 43605
 2644
 0.23
chr9_57650943_57651123 0.29 Csk
 c-src tyrosine kinase
 2438
 0.18
chr6_124712989_124713179 0.29 Phb2
 prohibitin 2
 38
 0.88
chr2_103713943_103714113 0.29 Abtb2
 ankyrin repeat and BTB (POZ) domain containing 2
 1007
 0.49
chr5_139364533_139364950 0.28 Mir339
 microRNA 339
 5004
 0.12
chr4_63252131_63252305 0.28 Mir455
 microRNA 455
 4633
 0.19
chr2_72179596_72179778 0.28 Rapgef4
 Rap guanine nucleotide exchange factor (GEF) 4
 6
 0.98
chr14_47472459_47472619 0.28 Fbxo34
 F-box protein 34
 22
 0.96
chr2_167834679_167834867 0.27 1200007C13Rik
 RIKEN cDNA 1200007C13 gene
 1127
 0.46
chr13_34742265_34742434 0.27 Fam50b
 family with sequence similarity 50, member B
 2737
 0.19
chr13_58960766_58960939 0.27 Ntrk2
 neurotrophic tyrosine kinase, receptor, type 2
 89117
 0.07
chr7_19797262_19797473 0.27 Cblc
 Casitas B-lineage lymphoma c
 558
 0.52
chr9_21546507_21546700 0.27 Carm1
 coactivator-associated arginine methyltransferase 1
 291
 0.82
chrX_20425191_20425364 0.27 Jade3
 jade family PHD finger 3
 411
 0.81
chr4_53440081_53440358 0.27 Slc44a1
 solute carrier family 44, member 1
 194
 0.96
chr7_127886041_127886230 0.27 Prss53
 protease, serine 53
 4832
 0.07
chr11_5846893_5847128 0.27 Polm
 polymerase (DNA directed), mu
 8994
 0.11
chr9_103007772_103008092 0.26 Slco2a1
 solute carrier organic anion transporter family, member 2a1
 70
 0.97
chr9_117357124_117357284 0.26 Gm20396
 predicted gene 20396
 45775
 0.18
chr4_133967614_133967768 0.26 Hmgn2
 high mobility group nucleosomal binding domain 2
 170
 0.93
chr7_75762457_75762611 0.26 Gm23251
 predicted gene, 23251
 5166
 0.17
chr7_133728557_133728948 0.26 Dhx32
 DEAH (Asp-Glu-Ala-His) box polypeptide 32
 2148
 0.2
chr2_5669776_5669983 0.26 Camk1d
 calcium/calmodulin-dependent protein kinase ID
 6167
 0.27
chr8_83738255_83738433 0.26 Adgre5
 adhesion G protein-coupled receptor E5
 2825
 0.16
chr13_46888106_46888269 0.26 Gm48250
 predicted gene, 48250
 7160
 0.15
chr9_71153822_71154046 0.26 Aqp9
 aquaporin 9
 8699
 0.18
chr8_94186443_94186638 0.26 Gm39228
 predicted gene, 39228
 3251
 0.13
chr15_82378546_82378931 0.26 Cyp2d22
 cytochrome P450, family 2, subfamily d, polypeptide 22
 1505
 0.16
chr8_116581400_116581581 0.26 Dynlrb2
 dynein light chain roadblock-type 2
 76475
 0.1
chr15_90679373_90679524 0.25 Cpne8
 copine VIII
 16
 0.98
chr18_11205176_11205343 0.25 Gata6
 GATA binding protein 6
 146212
 0.04
chr11_109487198_109487366 0.25 Arsg
 arylsulfatase G
 1676
 0.26
chr2_168003768_168003979 0.25 Gm14236
 predicted gene 14236
 6656
 0.16

Histogram of CRE-TSS distances for CREs targeted by :

Histogram of

Rank distribution of CRE target scores:

Histogram of target CRE score.

Distribution of target CREs across different genomic regions:

Weighted Piechart of Weighted Piechart of Weighted Piechart of

Network of associatons between targets according to the STRING database.

First level regulatory network of Tfap2b

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.5 GO:0003162 atrioventricular node development(GO:0003162)
0.2 0.5 GO:1990705 cholangiocyte proliferation(GO:1990705)
0.2 0.5 GO:0070384 Harderian gland development(GO:0070384)
0.1 0.4 GO:1901475 pyruvate transmembrane transport(GO:1901475)
0.1 0.4 GO:0035771 interleukin-4-mediated signaling pathway(GO:0035771)
0.1 0.4 GO:0035425 autocrine signaling(GO:0035425)
0.1 0.3 GO:0018992 germ-line sex determination(GO:0018992)
0.1 0.3 GO:0003166 bundle of His development(GO:0003166)
0.1 0.4 GO:0097490 trunk segmentation(GO:0035290) trunk neural crest cell migration(GO:0036484) ventral trunk neural crest cell migration(GO:0036486) sympathetic neuron projection extension(GO:0097490) sympathetic neuron projection guidance(GO:0097491)
0.1 0.6 GO:0043951 negative regulation of cAMP-mediated signaling(GO:0043951)
0.1 0.2 GO:0009826 unidimensional cell growth(GO:0009826)
0.1 0.2 GO:0061470 T follicular helper cell differentiation(GO:0061470)
0.1 0.4 GO:0007171 activation of transmembrane receptor protein tyrosine kinase activity(GO:0007171)
0.1 0.4 GO:0019695 choline metabolic process(GO:0019695)
0.1 0.2 GO:1903261 regulation of serine phosphorylation of STAT3 protein(GO:1903261)
0.1 0.2 GO:0003419 growth plate cartilage chondrocyte proliferation(GO:0003419)
0.1 0.3 GO:0042769 DNA damage response, detection of DNA damage(GO:0042769)
0.1 0.5 GO:0006689 ganglioside catabolic process(GO:0006689)
0.1 0.3 GO:1903361 protein localization to basolateral plasma membrane(GO:1903361)
0.1 0.3 GO:1901026 ripoptosome assembly(GO:0097343) ripoptosome assembly involved in necroptotic process(GO:1901026)
0.1 0.3 GO:0070945 neutrophil mediated killing of gram-negative bacterium(GO:0070945)
0.1 0.5 GO:0048096 chromatin-mediated maintenance of transcription(GO:0048096)
0.1 0.2 GO:0071462 cellular response to water stimulus(GO:0071462)
0.0 0.2 GO:0086045 membrane depolarization during AV node cell action potential(GO:0086045)
0.0 0.2 GO:0007217 tachykinin receptor signaling pathway(GO:0007217)
0.0 0.3 GO:0015871 choline transport(GO:0015871)
0.0 0.2 GO:1904528 regulation of microtubule binding(GO:1904526) positive regulation of microtubule binding(GO:1904528)
0.0 0.1 GO:0045054 constitutive secretory pathway(GO:0045054)
0.0 0.3 GO:0042695 thelarche(GO:0042695) mammary gland branching involved in thelarche(GO:0060744)
0.0 0.1 GO:0038095 Fc-epsilon receptor signaling pathway(GO:0038095)
0.0 0.2 GO:0021914 negative regulation of smoothened signaling pathway involved in ventral spinal cord patterning(GO:0021914)
0.0 0.1 GO:0000720 pyrimidine dimer repair by nucleotide-excision repair(GO:0000720)
0.0 0.4 GO:0006020 inositol metabolic process(GO:0006020)
0.0 0.1 GO:0060066 oviduct development(GO:0060066)
0.0 0.1 GO:0098902 regulation of membrane depolarization during action potential(GO:0098902)
0.0 0.1 GO:0009597 detection of virus(GO:0009597)
0.0 0.1 GO:0060137 maternal process involved in parturition(GO:0060137)
0.0 0.1 GO:0051562 negative regulation of mitochondrial calcium ion concentration(GO:0051562)
0.0 0.1 GO:0090074 negative regulation of protein homodimerization activity(GO:0090074)
0.0 0.1 GO:0010535 positive regulation of activation of JAK2 kinase activity(GO:0010535)
0.0 0.3 GO:0010388 cullin deneddylation(GO:0010388)
0.0 0.1 GO:0071930 negative regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0071930)
0.0 0.1 GO:0015015 heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.0 0.2 GO:0006776 vitamin A metabolic process(GO:0006776)
0.0 0.2 GO:0048133 germ-line stem cell division(GO:0042078) male germ-line stem cell asymmetric division(GO:0048133) germline stem cell asymmetric division(GO:0098728)
0.0 0.1 GO:0071596 ubiquitin-dependent protein catabolic process via the N-end rule pathway(GO:0071596)
0.0 0.1 GO:0006651 diacylglycerol biosynthetic process(GO:0006651)
0.0 0.1 GO:1900739 regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900739) positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900740)
0.0 0.2 GO:0043983 histone H4-K12 acetylation(GO:0043983)
0.0 0.1 GO:2000705 regulation of dense core granule biogenesis(GO:2000705)
0.0 0.2 GO:0001561 fatty acid alpha-oxidation(GO:0001561)
0.0 0.1 GO:0034197 acylglycerol transport(GO:0034196) triglyceride transport(GO:0034197)
0.0 0.1 GO:0008050 female courtship behavior(GO:0008050)
0.0 0.1 GO:0003199 endocardial cushion to mesenchymal transition involved in heart valve formation(GO:0003199)
0.0 0.2 GO:0021800 cerebral cortex tangential migration(GO:0021800)
0.0 0.1 GO:0006987 activation of signaling protein activity involved in unfolded protein response(GO:0006987)
0.0 0.0 GO:0086046 membrane depolarization during SA node cell action potential(GO:0086046)
0.0 0.1 GO:0021564 vagus nerve development(GO:0021564)
0.0 0.1 GO:2001199 negative regulation of dendritic cell differentiation(GO:2001199)
0.0 0.0 GO:0035799 ureter maturation(GO:0035799)
0.0 0.1 GO:0060155 platelet dense granule organization(GO:0060155)
0.0 0.1 GO:1902969 mitotic DNA replication(GO:1902969)
0.0 0.1 GO:0070295 renal water absorption(GO:0070295)
0.0 0.1 GO:0001828 inner cell mass cellular morphogenesis(GO:0001828)
0.0 0.1 GO:0009202 deoxyribonucleoside triphosphate biosynthetic process(GO:0009202)
0.0 0.2 GO:2000672 negative regulation of motor neuron apoptotic process(GO:2000672)
0.0 0.1 GO:0006432 phenylalanyl-tRNA aminoacylation(GO:0006432)
0.0 0.2 GO:0032000 positive regulation of fatty acid beta-oxidation(GO:0032000)
0.0 0.1 GO:0051387 negative regulation of neurotrophin TRK receptor signaling pathway(GO:0051387)
0.0 0.1 GO:2000646 positive regulation of receptor catabolic process(GO:2000646)
0.0 0.3 GO:0043968 histone H2A acetylation(GO:0043968)
0.0 0.1 GO:0006703 estrogen biosynthetic process(GO:0006703)
0.0 0.1 GO:1902268 negative regulation of polyamine transmembrane transport(GO:1902268)
0.0 0.2 GO:0098908 regulation of neuronal action potential(GO:0098908)
0.0 0.0 GO:1902809 regulation of skeletal muscle fiber differentiation(GO:1902809)
0.0 0.0 GO:0019344 cysteine biosynthetic process(GO:0019344)
0.0 0.1 GO:0071918 urea transmembrane transport(GO:0071918)
0.0 0.1 GO:0000414 regulation of histone H3-K36 methylation(GO:0000414)
0.0 0.1 GO:1902564 negative regulation of neutrophil activation(GO:1902564)
0.0 0.1 GO:0070673 response to interleukin-18(GO:0070673)
0.0 0.5 GO:0060561 apoptotic process involved in morphogenesis(GO:0060561)
0.0 0.1 GO:0006104 succinyl-CoA metabolic process(GO:0006104)
0.0 0.1 GO:0016561 protein import into peroxisome matrix, translocation(GO:0016561)
0.0 0.3 GO:0051181 cofactor transport(GO:0051181)
0.0 0.1 GO:0015691 cadmium ion transport(GO:0015691) cadmium ion transmembrane transport(GO:0070574)
0.0 0.1 GO:0006868 glutamine transport(GO:0006868)
0.0 0.1 GO:0019249 lactate biosynthetic process from pyruvate(GO:0019244) lactate biosynthetic process(GO:0019249)
0.0 0.1 GO:0070889 platelet alpha granule organization(GO:0070889)
0.0 0.1 GO:0035542 regulation of SNARE complex assembly(GO:0035542)
0.0 0.1 GO:0002282 microglial cell activation involved in immune response(GO:0002282)
0.0 0.1 GO:1902990 mitotic telomere maintenance via semi-conservative replication(GO:1902990)
0.0 0.1 GO:0010989 negative regulation of low-density lipoprotein particle clearance(GO:0010989)
0.0 0.1 GO:0044027 hypermethylation of CpG island(GO:0044027)
0.0 0.1 GO:0019673 GDP-mannose metabolic process(GO:0019673)
0.0 0.0 GO:0042938 dipeptide transport(GO:0042938)
0.0 0.1 GO:0018242 protein O-linked glycosylation via serine(GO:0018242)
0.0 0.1 GO:0036438 maintenance of lens transparency(GO:0036438)
0.0 0.6 GO:0051693 actin filament capping(GO:0051693)
0.0 0.3 GO:0048026 positive regulation of mRNA splicing, via spliceosome(GO:0048026)
0.0 0.1 GO:0007199 G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger(GO:0007199)
0.0 0.1 GO:2000394 positive regulation of lamellipodium morphogenesis(GO:2000394)
0.0 0.1 GO:0018401 peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401)
0.0 0.0 GO:1902661 regulation of glucose mediated signaling pathway(GO:1902659) positive regulation of glucose mediated signaling pathway(GO:1902661)
0.0 0.2 GO:0033280 response to vitamin D(GO:0033280)
0.0 0.1 GO:0031944 negative regulation of glucocorticoid metabolic process(GO:0031944) negative regulation of glucocorticoid biosynthetic process(GO:0031947)
0.0 0.1 GO:0007386 compartment pattern specification(GO:0007386)
0.0 0.3 GO:0030224 monocyte differentiation(GO:0030224)
0.0 0.1 GO:0032353 negative regulation of hormone biosynthetic process(GO:0032353)
0.0 0.1 GO:0061314 Notch signaling involved in heart development(GO:0061314)
0.0 0.1 GO:0072675 osteoclast fusion(GO:0072675)
0.0 0.4 GO:0036075 endochondral ossification(GO:0001958) replacement ossification(GO:0036075)
0.0 0.0 GO:0001698 gastrin-induced gastric acid secretion(GO:0001698)
0.0 0.0 GO:0007039 protein catabolic process in the vacuole(GO:0007039)
0.0 0.2 GO:0051292 nuclear pore complex assembly(GO:0051292)
0.0 0.4 GO:0090162 establishment of epithelial cell polarity(GO:0090162)
0.0 0.0 GO:0060468 prevention of polyspermy(GO:0060468)
0.0 0.0 GO:0002432 granuloma formation(GO:0002432)
0.0 0.1 GO:0048069 eye pigmentation(GO:0048069)
0.0 0.1 GO:0001712 ectodermal cell fate commitment(GO:0001712)
0.0 0.1 GO:2000667 positive regulation of interleukin-5 secretion(GO:2000664) positive regulation of interleukin-13 secretion(GO:2000667)
0.0 0.1 GO:0002924 negative regulation of humoral immune response mediated by circulating immunoglobulin(GO:0002924)
0.0 0.1 GO:0051639 actin filament network formation(GO:0051639)
0.0 0.0 GO:0090296 regulation of mitochondrial DNA replication(GO:0090296)
0.0 0.2 GO:0001886 endothelial cell morphogenesis(GO:0001886)
0.0 0.0 GO:0051599 response to hydrostatic pressure(GO:0051599)
0.0 0.1 GO:0035459 cargo loading into vesicle(GO:0035459)
0.0 0.3 GO:0070584 mitochondrion morphogenesis(GO:0070584)
0.0 0.1 GO:0061179 negative regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0061179)
0.0 0.1 GO:0042891 antibiotic transport(GO:0042891)
0.0 0.1 GO:0051764 actin crosslink formation(GO:0051764)
0.0 0.1 GO:0034063 stress granule assembly(GO:0034063)
0.0 0.3 GO:0030318 melanocyte differentiation(GO:0030318)
0.0 0.2 GO:0097237 cellular response to toxic substance(GO:0097237)
0.0 0.1 GO:0002408 myeloid dendritic cell chemotaxis(GO:0002408)
0.0 0.2 GO:0048368 lateral mesoderm development(GO:0048368)
0.0 0.1 GO:0019934 cGMP-mediated signaling(GO:0019934)
0.0 0.0 GO:0001757 somite specification(GO:0001757)
0.0 0.1 GO:0017014 protein nitrosylation(GO:0017014)
0.0 0.0 GO:0021888 hypothalamus gonadotrophin-releasing hormone neuron differentiation(GO:0021886) hypothalamus gonadotrophin-releasing hormone neuron development(GO:0021888)
0.0 0.1 GO:0021707 cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
0.0 0.1 GO:0010457 centriole-centriole cohesion(GO:0010457)
0.0 0.1 GO:0048242 epinephrine secretion(GO:0048242)
0.0 0.0 GO:0045218 zonula adherens maintenance(GO:0045218)
0.0 0.0 GO:0072300 positive regulation of metanephric glomerulus development(GO:0072300)
0.0 0.1 GO:0046415 urate metabolic process(GO:0046415)
0.0 0.0 GO:0051344 negative regulation of cyclic-nucleotide phosphodiesterase activity(GO:0051344)
0.0 0.0 GO:0048696 regulation of collateral sprouting in absence of injury(GO:0048696)
0.0 0.1 GO:0009437 carnitine metabolic process(GO:0009437)
0.0 0.1 GO:0010815 bradykinin catabolic process(GO:0010815)
0.0 0.2 GO:0061036 positive regulation of cartilage development(GO:0061036)
0.0 0.0 GO:0071332 cellular response to fructose stimulus(GO:0071332)
0.0 0.1 GO:0009115 xanthine catabolic process(GO:0009115)
0.0 0.0 GO:0006015 5-phosphoribose 1-diphosphate biosynthetic process(GO:0006015) 5-phosphoribose 1-diphosphate metabolic process(GO:0046391)
0.0 0.0 GO:2001046 positive regulation of integrin-mediated signaling pathway(GO:2001046)
0.0 0.1 GO:0060267 positive regulation of respiratory burst(GO:0060267)
0.0 0.0 GO:2001286 regulation of caveolin-mediated endocytosis(GO:2001286)
0.0 0.0 GO:0051684 maintenance of Golgi location(GO:0051684)
0.0 0.0 GO:0061642 chemoattraction of axon(GO:0061642)
0.0 0.1 GO:0043031 negative regulation of macrophage activation(GO:0043031)
0.0 0.0 GO:0061687 detoxification of inorganic compound(GO:0061687)
0.0 0.1 GO:0019852 L-ascorbic acid metabolic process(GO:0019852)
0.0 0.1 GO:0021999 neural plate anterior/posterior regionalization(GO:0021999) neural plate regionalization(GO:0060897)
0.0 0.1 GO:1903608 protein localization to cytoplasmic stress granule(GO:1903608)
0.0 0.3 GO:0043252 sodium-independent organic anion transport(GO:0043252)
0.0 0.1 GO:0035188 blastocyst hatching(GO:0001835) hatching(GO:0035188) organism emergence from protective structure(GO:0071684)
0.0 0.0 GO:0018894 dibenzo-p-dioxin metabolic process(GO:0018894)
0.0 0.0 GO:0070885 negative regulation of calcineurin-NFAT signaling cascade(GO:0070885)
0.0 0.0 GO:0061052 negative regulation of cell growth involved in cardiac muscle cell development(GO:0061052)
0.0 0.1 GO:1900746 regulation of vascular endothelial growth factor signaling pathway(GO:1900746)
0.0 0.0 GO:0007494 midgut development(GO:0007494)
0.0 0.0 GO:0035087 siRNA loading onto RISC involved in RNA interference(GO:0035087)
0.0 0.0 GO:0035887 aortic smooth muscle cell differentiation(GO:0035887)
0.0 0.0 GO:2000574 regulation of microtubule motor activity(GO:2000574)
0.0 0.1 GO:0007175 negative regulation of epidermal growth factor-activated receptor activity(GO:0007175)
0.0 0.0 GO:0043133 hindgut contraction(GO:0043133) regulation of hindgut contraction(GO:0043134)
0.0 0.0 GO:0061589 calcium activated phosphatidylserine scrambling(GO:0061589)
0.0 0.0 GO:0031086 nuclear-transcribed mRNA catabolic process, deadenylation-independent decay(GO:0031086) deadenylation-independent decapping of nuclear-transcribed mRNA(GO:0031087)
0.0 0.0 GO:0051890 regulation of cardioblast differentiation(GO:0051890)
0.0 0.0 GO:0044838 cell quiescence(GO:0044838)
0.0 0.2 GO:0001522 pseudouridine synthesis(GO:0001522)
0.0 0.1 GO:0051547 regulation of keratinocyte migration(GO:0051547) positive regulation of keratinocyte migration(GO:0051549)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.5 GO:0002193 MAML1-RBP-Jkappa- ICN1 complex(GO:0002193)
0.1 0.6 GO:0008091 spectrin(GO:0008091)
0.1 0.6 GO:0031931 TORC1 complex(GO:0031931)
0.1 0.2 GO:0030981 cortical microtubule cytoskeleton(GO:0030981)
0.0 0.1 GO:0097443 sorting endosome(GO:0097443)
0.0 0.1 GO:0031084 BLOC-2 complex(GO:0031084)
0.0 0.1 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.0 0.5 GO:0032797 SMN complex(GO:0032797)
0.0 0.4 GO:0005766 primary lysosome(GO:0005766) azurophil granule(GO:0042582)
0.0 0.1 GO:0000811 GINS complex(GO:0000811)
0.0 0.2 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.0 0.1 GO:0038037 G-protein coupled receptor dimeric complex(GO:0038037) G-protein coupled receptor complex(GO:0097648)
0.0 0.1 GO:0044316 cone cell pedicle(GO:0044316)
0.0 0.3 GO:0065010 extracellular membrane-bounded organelle(GO:0065010)
0.0 0.5 GO:0005721 pericentric heterochromatin(GO:0005721)
0.0 0.1 GO:0035189 Rb-E2F complex(GO:0035189)
0.0 0.1 GO:0033553 rDNA heterochromatin(GO:0033553)
0.0 0.1 GO:0097255 R2TP complex(GO:0097255)
0.0 0.2 GO:0097542 ciliary tip(GO:0097542)
0.0 0.1 GO:0000322 storage vacuole(GO:0000322)
0.0 0.1 GO:1990597 AIP1-IRE1 complex(GO:1990597)
0.0 0.3 GO:0016580 Sin3 complex(GO:0016580)
0.0 0.2 GO:0098563 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.0 0.0 GO:0036488 CHOP-C/EBP complex(GO:0036488)
0.0 0.1 GO:0097629 extrinsic component of omegasome membrane(GO:0097629)
0.0 0.2 GO:0043219 lateral loop(GO:0043219)
0.0 0.1 GO:0030062 mitochondrial tricarboxylic acid cycle enzyme complex(GO:0030062)
0.0 0.2 GO:0061700 GATOR2 complex(GO:0061700)
0.0 0.1 GO:0005796 Golgi lumen(GO:0005796)
0.0 0.1 GO:0019815 B cell receptor complex(GO:0019815)
0.0 0.1 GO:0005579 membrane attack complex(GO:0005579)
0.0 0.1 GO:0031080 nuclear pore outer ring(GO:0031080)
0.0 0.1 GO:0097197 tetraspanin-enriched microdomain(GO:0097197)
0.0 0.1 GO:0097418 neurofibrillary tangle(GO:0097418)
0.0 0.0 GO:0097513 myosin II filament(GO:0097513)
0.0 0.1 GO:0042105 alpha-beta T cell receptor complex(GO:0042105)
0.0 0.1 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
0.0 0.1 GO:0031264 death-inducing signaling complex(GO:0031264)
0.0 0.5 GO:0001917 photoreceptor inner segment(GO:0001917)
0.0 0.0 GO:0044354 pinosome(GO:0044352) macropinosome(GO:0044354)
0.0 0.1 GO:0000235 astral microtubule(GO:0000235)
0.0 0.1 GO:0042555 MCM complex(GO:0042555)
0.0 0.4 GO:0031901 early endosome membrane(GO:0031901)
0.0 0.3 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 0.1 GO:0044232 organelle membrane contact site(GO:0044232)
0.0 0.1 GO:0045180 basal cortex(GO:0045180)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.5 GO:0001031 RNA polymerase III type 1 promoter DNA binding(GO:0001030) RNA polymerase III type 2 promoter DNA binding(GO:0001031) RNA polymerase III type 3 promoter DNA binding(GO:0001032) 5S rDNA binding(GO:0080084)
0.1 0.4 GO:0050833 pyruvate transmembrane transporter activity(GO:0050833)
0.1 0.3 GO:0051733 ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity(GO:0046404) polydeoxyribonucleotide kinase activity(GO:0051733)
0.1 0.3 GO:0004104 cholinesterase activity(GO:0004104)
0.1 0.7 GO:0034560 3-(3-hydroxyphenyl)propionate hydroxylase activity(GO:0008688) 4-chlorobenzaldehyde oxidase activity(GO:0018471) 3,5-xylenol methylhydroxylase activity(GO:0018630) phenylacetate hydroxylase activity(GO:0018631) 4-nitrophenol 4-monooxygenase activity(GO:0018632) dimethyl sulfide monooxygenase activity(GO:0018633) alpha-pinene monooxygenase [NADH] activity(GO:0018634) 1-hydroxy-2-naphthoate hydroxylase activity(GO:0018637) toluene 4-monooxygenase activity(GO:0018638) xylene monooxygenase activity(GO:0018639) dibenzothiophene monooxygenase activity(GO:0018640) 6-hydroxy-3-methyl-2-oxo-1,2-dihydroquinoline 6-monooxygenase activity(GO:0018641) chlorophenol 4-monooxygenase activity(GO:0018642) carbon disulfide oxygenase activity(GO:0018643) toluene 2-monooxygenase activity(GO:0018644) 1-hydroxy-2-oxolimonene 1,2-monooxygenase activity(GO:0018646) phenanthrene 1,2-monooxygenase activity(GO:0018647) tetrahydrofuran hydroxylase activity(GO:0018649) styrene monooxygenase activity(GO:0018650) toluene-4-sulfonate monooxygenase activity(GO:0018651) toluene-sulfonate methyl-monooxygenase activity(GO:0018652) 3-methyl-2-oxo-1,2-dihydroquinoline 6-monooxygenase activity(GO:0018653) 2-hydroxy-phenylacetate hydroxylase activity(GO:0018654) 2-oxo-delta3-4,5,5-trimethylcyclopentenylacetyl-CoA 1,2-monooxygenase activity(GO:0018655) phenanthrene 3,4-monooxygenase activity(GO:0018656) toluene 3-monooxygenase activity(GO:0018657) 4-hydroxyphenylacetate,NADH:oxygen oxidoreductase (3-hydroxylating) activity(GO:0018660) limonene monooxygenase activity(GO:0019113) 2-methylnaphthalene hydroxylase activity(GO:0034526) 1-methylnaphthalene hydroxylase activity(GO:0034534) bisphenol A hydroxylase A activity(GO:0034560) salicylate 5-hydroxylase activity(GO:0034785) isobutylamine N-hydroxylase activity(GO:0034791) branched-chain dodecylbenzene sulfonate monooxygenase activity(GO:0034802) 3-HSA hydroxylase activity(GO:0034819) 4-hydroxypyridine-3-hydroxylase activity(GO:0034894) 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase activity(GO:0043719) 6-hydroxynicotinate 3-monooxygenase activity(GO:0043731) thalianol hydroxylase activity(GO:0080014)
0.1 0.5 GO:0004563 beta-N-acetylhexosaminidase activity(GO:0004563)
0.1 0.3 GO:0004035 alkaline phosphatase activity(GO:0004035)
0.1 0.3 GO:0097016 L27 domain binding(GO:0097016)
0.1 0.2 GO:0043533 inositol 1,3,4,5 tetrakisphosphate binding(GO:0043533)
0.1 0.3 GO:0002046 opsin binding(GO:0002046)
0.1 0.3 GO:0015220 choline transmembrane transporter activity(GO:0015220)
0.1 0.2 GO:0086056 voltage-gated calcium channel activity involved in AV node cell action potential(GO:0086056)
0.1 0.5 GO:0048027 mRNA 5'-UTR binding(GO:0048027)
0.1 0.4 GO:0003708 retinoic acid receptor activity(GO:0003708)
0.1 0.2 GO:0004703 G-protein coupled receptor kinase activity(GO:0004703)
0.1 0.4 GO:0008440 inositol-1,4,5-trisphosphate 3-kinase activity(GO:0008440)
0.1 0.2 GO:0043398 HLH domain binding(GO:0043398)
0.1 0.2 GO:0032767 copper-dependent protein binding(GO:0032767)
0.0 0.1 GO:0004699 calcium-independent protein kinase C activity(GO:0004699)
0.0 0.1 GO:0005001 transmembrane receptor protein tyrosine phosphatase activity(GO:0005001)
0.0 0.2 GO:0070051 fibrinogen binding(GO:0070051)
0.0 0.9 GO:0030506 ankyrin binding(GO:0030506)
0.0 0.6 GO:0070577 lysine-acetylated histone binding(GO:0070577)
0.0 0.2 GO:0070891 lipoteichoic acid binding(GO:0070891)
0.0 0.6 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)
0.0 0.1 GO:0004965 G-protein coupled GABA receptor activity(GO:0004965)
0.0 0.2 GO:0008420 CTD phosphatase activity(GO:0008420)
0.0 0.1 GO:0017162 aryl hydrocarbon receptor binding(GO:0017162)
0.0 0.3 GO:0038191 neuropilin binding(GO:0038191)
0.0 0.1 GO:0017153 sodium:dicarboxylate symporter activity(GO:0017153)
0.0 0.4 GO:0005161 platelet-derived growth factor receptor binding(GO:0005161)
0.0 0.2 GO:1990380 Lys48-specific deubiquitinase activity(GO:1990380)
0.0 0.1 GO:0042895 antibiotic transporter activity(GO:0042895)
0.0 0.1 GO:0060230 lipoprotein lipase activator activity(GO:0060230)
0.0 0.4 GO:0008601 protein phosphatase type 2A regulator activity(GO:0008601)
0.0 0.2 GO:0047035 testosterone dehydrogenase (NAD+) activity(GO:0047035)
0.0 0.2 GO:0005078 MAP-kinase scaffold activity(GO:0005078)
0.0 0.1 GO:0003846 2-acylglycerol O-acyltransferase activity(GO:0003846)
0.0 0.2 GO:0001091 RNA polymerase II basal transcription factor binding(GO:0001091)
0.0 0.1 GO:0038085 vascular endothelial growth factor binding(GO:0038085)
0.0 0.1 GO:0036374 gamma-glutamyltransferase activity(GO:0003840) glutathione hydrolase activity(GO:0036374)
0.0 0.1 GO:0017169 CDP-alcohol phosphatidyltransferase activity(GO:0017169)
0.0 0.2 GO:0015651 quaternary ammonium group transmembrane transporter activity(GO:0015651)
0.0 0.2 GO:0034943 3-oxo-2-(2'-pentenyl)cyclopentane-1-octanoic acid CoA ligase activity(GO:0010435) 3-isopropenyl-6-oxoheptanoyl-CoA synthetase activity(GO:0018854) 2-oxo-delta3-4,5,5-trimethylcyclopentenylacetyl-CoA synthetase activity(GO:0018855) benzoyl acetate-CoA ligase activity(GO:0018856) 2,4-dichlorobenzoate-CoA ligase activity(GO:0018857) pivalate-CoA ligase activity(GO:0034783) cyclopropanecarboxylate-CoA ligase activity(GO:0034793) adipate-CoA ligase activity(GO:0034796) citronellyl-CoA ligase activity(GO:0034823) mentha-1,3-dione-CoA ligase activity(GO:0034841) thiophene-2-carboxylate-CoA ligase activity(GO:0034842) 2,4,4-trimethylpentanoate-CoA ligase activity(GO:0034865) cis-2-methyl-5-isopropylhexa-2,5-dienoate-CoA ligase activity(GO:0034942) trans-2-methyl-5-isopropylhexa-2,5-dienoate-CoA ligase activity(GO:0034943) branched-chain acyl-CoA synthetase (ADP-forming) activity(GO:0043759) aryl-CoA synthetase (ADP-forming) activity(GO:0043762) 3-hydroxypropionyl-CoA synthetase activity(GO:0043955) perillic acid:CoA ligase (ADP-forming) activity(GO:0052685) perillic acid:CoA ligase (AMP-forming) activity(GO:0052686) (3R)-3-isopropenyl-6-oxoheptanoate:CoA ligase (ADP-forming) activity(GO:0052687) (3R)-3-isopropenyl-6-oxoheptanoate:CoA ligase (AMP-forming) activity(GO:0052688) pristanate-CoA ligase activity(GO:0070251) malonyl-CoA synthetase activity(GO:0090409)
0.0 0.1 GO:0008073 ornithine decarboxylase inhibitor activity(GO:0008073)
0.0 0.1 GO:0016649 electron-transferring-flavoprotein dehydrogenase activity(GO:0004174) oxidoreductase activity, acting on the CH-NH group of donors, quinone or similar compound as acceptor(GO:0016649)
0.0 0.1 GO:0004739 pyruvate dehydrogenase (acetyl-transferring) activity(GO:0004739)
0.0 0.1 GO:0005345 purine nucleobase transmembrane transporter activity(GO:0005345) pyrimidine nucleobase transmembrane transporter activity(GO:0005350) nucleobase transmembrane transporter activity(GO:0015205)
0.0 0.1 GO:0035615 clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)
0.0 0.1 GO:0005049 nuclear export signal receptor activity(GO:0005049)
0.0 0.1 GO:0015288 porin activity(GO:0015288)
0.0 0.1 GO:0015057 thrombin receptor activity(GO:0015057)
0.0 0.1 GO:0015182 L-asparagine transmembrane transporter activity(GO:0015182) L-glutamine transmembrane transporter activity(GO:0015186)
0.0 0.1 GO:0004459 L-lactate dehydrogenase activity(GO:0004459)
0.0 0.1 GO:0004826 phenylalanine-tRNA ligase activity(GO:0004826)
0.0 0.2 GO:0051010 microtubule plus-end binding(GO:0051010)
0.0 0.1 GO:0004719 protein-L-isoaspartate (D-aspartate) O-methyltransferase activity(GO:0004719)
0.0 0.4 GO:0030742 GTP-dependent protein binding(GO:0030742)
0.0 0.1 GO:0008454 alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.0 0.3 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.0 0.1 GO:0016971 flavin-linked sulfhydryl oxidase activity(GO:0016971)
0.0 0.1 GO:0008545 JUN kinase kinase activity(GO:0008545)
0.0 0.1 GO:0019145 aminobutyraldehyde dehydrogenase activity(GO:0019145) 4-trimethylammoniobutyraldehyde dehydrogenase activity(GO:0047105)
0.0 0.1 GO:0033829 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
0.0 0.1 GO:0015087 cobalt ion transmembrane transporter activity(GO:0015087)
0.0 0.0 GO:0071535 RING-like zinc finger domain binding(GO:0071535)
0.0 0.1 GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
0.0 0.6 GO:0042605 peptide antigen binding(GO:0042605)
0.0 0.1 GO:0008349 MAP kinase kinase kinase kinase activity(GO:0008349)
0.0 0.1 GO:0030550 acetylcholine receptor inhibitor activity(GO:0030550)
0.0 0.1 GO:0005143 interleukin-12 receptor binding(GO:0005143)
0.0 0.2 GO:0019841 retinol binding(GO:0019841)
0.0 0.1 GO:0004031 aldehyde oxidase activity(GO:0004031) oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor(GO:0016623)
0.0 0.1 GO:0016176 superoxide-generating NADPH oxidase activator activity(GO:0016176)
0.0 0.1 GO:0046624 sphingolipid transporter activity(GO:0046624)
0.0 0.1 GO:0015245 fatty acid transporter activity(GO:0015245)
0.0 0.1 GO:0015173 aromatic amino acid transmembrane transporter activity(GO:0015173)
0.0 0.1 GO:0048019 receptor antagonist activity(GO:0048019)
0.0 0.0 GO:0071209 U7 snRNA binding(GO:0071209)
0.0 0.1 GO:0008517 folic acid transporter activity(GO:0008517)
0.0 0.0 GO:0004920 interleukin-10 receptor activity(GO:0004920)
0.0 0.1 GO:0035613 RNA stem-loop binding(GO:0035613)
0.0 0.1 GO:0031545 peptidyl-proline 4-dioxygenase activity(GO:0031545)
0.0 0.0 GO:0070840 dynein complex binding(GO:0070840)
0.0 0.2 GO:0009982 pseudouridine synthase activity(GO:0009982)
0.0 0.1 GO:0032052 bile acid binding(GO:0032052)
0.0 0.1 GO:0000268 peroxisome targeting sequence binding(GO:0000268)
0.0 0.1 GO:0031996 thioesterase binding(GO:0031996)
0.0 0.0 GO:0015143 urate transmembrane transporter activity(GO:0015143) salt transmembrane transporter activity(GO:1901702)
0.0 0.1 GO:0086080 protein binding involved in heterotypic cell-cell adhesion(GO:0086080)
0.0 0.0 GO:0004969 histamine receptor activity(GO:0004969)
0.0 0.1 GO:0042301 phosphate ion binding(GO:0042301)
0.0 0.0 GO:0015038 glutathione disulfide oxidoreductase activity(GO:0015038)
0.0 0.2 GO:0070064 proline-rich region binding(GO:0070064)
0.0 0.2 GO:0003785 actin monomer binding(GO:0003785)
0.0 0.0 GO:1990430 extracellular matrix protein binding(GO:1990430)
0.0 0.1 GO:0010181 FMN binding(GO:0010181)
0.0 0.1 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.0 0.2 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.0 0.1 GO:0008190 eukaryotic initiation factor 4E binding(GO:0008190)
0.0 0.0 GO:0004887 thyroid hormone receptor activity(GO:0004887)
0.0 0.3 GO:0052771 coenzyme F390-A hydrolase activity(GO:0052770) coenzyme F390-G hydrolase activity(GO:0052771)
0.0 0.1 GO:0030274 LIM domain binding(GO:0030274)
0.0 0.0 GO:0004720 protein-lysine 6-oxidase activity(GO:0004720)
0.0 0.1 GO:0016443 bidentate ribonuclease III activity(GO:0016443)
0.0 0.0 GO:0019961 interferon binding(GO:0019961)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 SA TRKA RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.
0.1 0.1 ST DIFFERENTIATION PATHWAY IN PC12 CELLS Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway.
0.0 0.3 ST PAC1 RECEPTOR PATHWAY PAC1 Receptor Pathway
0.0 0.2 PID AJDISS 2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.0 0.4 PID DNA PK PATHWAY DNA-PK pathway in nonhomologous end joining
0.0 0.5 PID RHODOPSIN PATHWAY Visual signal transduction: Rods
0.0 0.1 PID VEGF VEGFR PATHWAY VEGF and VEGFR signaling network
0.0 0.2 PID TCR JNK PATHWAY JNK signaling in the CD4+ TCR pathway
0.0 0.0 PID GMCSF PATHWAY GMCSF-mediated signaling events
0.0 0.5 PID HIF2PATHWAY HIF-2-alpha transcription factor network
0.0 0.8 PID IL12 2PATHWAY IL12-mediated signaling events
0.0 0.3 PID RXR VDR PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.0 0.1 PID IL5 PATHWAY IL5-mediated signaling events
0.0 0.5 PID HES HEY PATHWAY Notch-mediated HES/HEY network
0.0 0.1 PID AURORA A PATHWAY Aurora A signaling
0.0 0.4 PID CDC42 REG PATHWAY Regulation of CDC42 activity
0.0 0.2 PID LPA4 PATHWAY LPA4-mediated signaling events
0.0 0.3 PID EPHRINB REV PATHWAY Ephrin B reverse signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 REACTOME MTORC1 MEDIATED SIGNALLING Genes involved in mTORC1-mediated signalling
0.1 0.5 REACTOME VEGF LIGAND RECEPTOR INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.1 0.6 REACTOME NOTCH HLH TRANSCRIPTION PATHWAY Genes involved in Notch-HLH transcription pathway
0.0 0.5 REACTOME HYALURONAN UPTAKE AND DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.0 0.5 REACTOME INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1 Genes involved in Inhibition of replication initiation of damaged DNA by RB1/E2F1
0.0 0.3 REACTOME TRANSPORT OF ORGANIC ANIONS Genes involved in Transport of organic anions
0.0 0.7 REACTOME SYNTHESIS OF PC Genes involved in Synthesis of PC
0.0 0.6 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.0 0.1 REACTOME XENOBIOTICS Genes involved in Xenobiotics
0.0 0.2 REACTOME NFKB ACTIVATION THROUGH FADD RIP1 PATHWAY MEDIATED BY CASPASE 8 AND10 Genes involved in NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
0.0 0.3 REACTOME P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS Genes involved in p130Cas linkage to MAPK signaling for integrins
0.0 0.2 REACTOME PASSIVE TRANSPORT BY AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.0 0.2 REACTOME GABA A RECEPTOR ACTIVATION Genes involved in GABA A receptor activation
0.0 0.2 REACTOME UNWINDING OF DNA Genes involved in Unwinding of DNA
0.0 0.2 REACTOME NOD1 2 SIGNALING PATHWAY Genes involved in NOD1/2 Signaling Pathway
0.0 0.2 REACTOME RAP1 SIGNALLING Genes involved in Rap1 signalling
0.0 0.0 REACTOME DESTABILIZATION OF MRNA BY BRF1 Genes involved in Destabilization of mRNA by Butyrate Response Factor 1 (BRF1)
0.0 0.2 REACTOME JNK C JUN KINASES PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1 Genes involved in JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
0.0 0.0 REACTOME GPVI MEDIATED ACTIVATION CASCADE Genes involved in GPVI-mediated activation cascade
0.0 0.1 REACTOME PD1 SIGNALING Genes involved in PD-1 signaling
0.0 0.3 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.0 0.6 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 0.1 REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.0 0.2 REACTOME EFFECTS OF PIP2 HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.0 0.1 REACTOME IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 Genes involved in IKK complex recruitment mediated by RIP1
0.0 0.3 REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits