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ENCSR904DTN: DNase-seq of mouse liver in constant darkness

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for Tfap2b

Z-value: 1.52

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Transcription factors associated with Tfap2b

Gene Symbol	Gene ID	Gene Info
Tfap2b Ensembl NCBI MGI UniProt	ENSMUSG00000025927.7	Tfap2b

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

Gene	Promoter	Distance	Association probability	Pearson corr. coef.	P-value	Plot
Tfap2b	chr1_19205686_19205886	3128	0.260115	-0.87	2.2e-02	Click!

Activity of the Tfap2b motif across conditions

Conditions sorted by the z-value of the Tfap2b motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr8_45333523_45333723	1.19	Cyp4v3	cytochrome P450, family 4, subfamily v, polypeptide 3	407	0.81
chr12_108856815_108857551	1.15	Gm22079	predicted gene, 22079	5486	0.1
chr7_102025342_102025783	1.13	Rnf121	ring finger protein 121	1093	0.33
chr2_181413297_181413448	1.13	Zbtb46	zinc finger and BTB domain containing 46	11016	0.1
chr2_167831188_167831379	1.09	1200007C13Rik	RIKEN cDNA 1200007C13 gene	2363	0.25
chr1_89669764_89670114	1.08	4933400F21Rik	RIKEN cDNA 4933400F21 gene	13949	0.24
chr9_107688467_107688630	1.06	Sema3f	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F	1231	0.26
chr9_50874153_50874482	1.06	Ppp2r1b	protein phosphatase 2, regulatory subunit A, beta	1305	0.4
chr10_85829643_85829823	1.01	Gm19624	predicted gene, 19624	9	0.75
chr4_57320936_57321111	0.93	Ptpn3	protein tyrosine phosphatase, non-receptor type 3	19186	0.15
chr10_63373532_63373708	0.88	Sirt1	sirtuin 1	8084	0.13
chr6_128102357_128102567	0.86	Gm26338	predicted gene, 26338	7436	0.15
chr1_179836517_179836707	0.84	Ahctf1	AT hook containing transcription factor 1	32932	0.16
chr16_22699066_22699230	0.83	Gm8118	predicted gene 8118	12954	0.18
chr11_119936702_119936872	0.82	Gm11766	predicted gene 11766	1724	0.24
chr7_45213806_45213957	0.82	Dkkl1	dickkopf-like 1	1734	0.12
chr7_143313622_143313928	0.81	Gm37364	predicted gene, 37364	16077	0.12
chr8_120622299_120622462	0.78	1190005I06Rik	RIKEN cDNA 1190005I06 gene	11983	0.09
chr5_110431894_110432052	0.77	Fbrsl1	fibrosin-like 1	1348	0.35
chr2_179292597_179292961	0.75	Gm14293	predicted gene 14293	52289	0.14
chr2_69911096_69911271	0.75	Ubr3	ubiquitin protein ligase E3 component n-recognin 3	13880	0.13
chr10_86685801_86686017	0.75	1810014B01Rik	RIKEN cDNA 1810014B01 gene	20	0.93
chr1_133877032_133877215	0.75	Optc	opticin	24204	0.12
chr1_167387431_167387591	0.75	Mgst3	microsomal glutathione S-transferase 3	6330	0.16
chr2_149759276_149759438	0.74	Gm14130	predicted gene 14130	16182	0.2
chr6_112883814_112883983	0.73	Srgap3	SLIT-ROBO Rho GTPase activating protein 3	54439	0.1
chr11_55406169_55406386	0.71	Sparc	secreted acidic cysteine rich glycoprotein	4112	0.19
chr7_19228252_19228443	0.70	Opa3	optic atrophy 3	13	0.94
chr12_76710114_76710283	0.68	Sptb	spectrin beta, erythrocytic	175	0.95
chr7_28969689_28969854	0.67	Eif3k	eukaryotic translation initiation factor 3, subunit K	5065	0.11
chr16_4912876_4913042	0.67	Mgrn1	mahogunin, ring finger 1	252	0.86
chr9_43467006_43467175	0.67	Gm28215	predicted gene 28215	2332	0.29
chr11_101369464_101369615	0.65	G6pc	glucose-6-phosphatase, catalytic	1978	0.11
chr1_165629214_165629365	0.65	Mpzl1	myelin protein zero-like 1	4797	0.13
chr1_153990768_153990949	0.64	Gm29291	predicted gene 29291	15359	0.15
chr4_148448716_148449227	0.63	Mtor	mechanistic target of rapamycin kinase	346	0.82
chr19_3850863_3851029	0.62	Chka	choline kinase alpha	827	0.37
chr10_39174337_39174497	0.62	D030034A15Rik	RIKEN cDNA D030034A15 gene	1165	0.4
chr7_49178293_49178474	0.62	Gm37613	predicted gene, 37613	17158	0.18
chr17_29394251_29394433	0.62	Fgd2	FYVE, RhoGEF and PH domain containing 2	17841	0.11
chr14_51100561_51100914	0.61	Rnase4	ribonuclease, RNase A family 4	4378	0.09
chr10_96377652_96377803	0.61	Gm20091	predicted gene, 20091	31311	0.14
chr13_32066979_32067135	0.60	Gm48885	predicted gene, 48885	32118	0.21
chr11_50292381_50292544	0.59	Maml1	mastermind like transcriptional coactivator 1	151	0.93
chr8_120437914_120438125	0.58	Gm22715	predicted gene, 22715	5530	0.21
chr5_104399237_104399791	0.58	Spp1	secreted phosphoprotein 1	35604	0.12
chr1_165461123_165461290	0.57	Mpc2	mitochondrial pyruvate carrier 2	18	0.92
chr9_59539398_59539715	0.56	Hexa	hexosaminidase A	16	0.8
chr5_139818915_139819083	0.56	Tmem184a	transmembrane protein 184a	918	0.45
chr18_31910656_31910818	0.55	Sft2d3	SFT2 domain containing 3	1087	0.41
chr17_32241257_32241435	0.55	Gm4432	predicted gene 4432	817	0.53
chr16_22163049_22163219	0.54	Igf2bp2	insulin-like growth factor 2 mRNA binding protein 2	115	0.96
chr11_45877769_45877933	0.54	Clint1	clathrin interactor 1	4546	0.19
chr5_135187024_135187335	0.53	Baz1b	bromodomain adjacent to zinc finger domain, 1B	85	0.95
chr12_111121851_111122115	0.52	Gm48632	predicted gene, 48632	30783	0.12
chr15_102243536_102243699	0.52	Rarg	retinoic acid receptor, gamma	28	0.95
chr8_119419822_119419973	0.51	Osgin1	oxidative stress induced growth inhibitor 1	14227	0.14
chr13_54249070_54249391	0.51	Gm48615	predicted gene, 48615	3934	0.19
chr6_125088559_125088736	0.51	2010008C14Rik	RIKEN cDNA 2010008C14 gene	5210	0.08
chr2_124858722_124858893	0.51	Gm13994	predicted gene 13994	150152	0.04
chr1_191946290_191946441	0.50	Rd3	retinal degeneration 3	31005	0.1
chr16_91822408_91822590	0.50	Itsn1	intersectin 1 (SH3 domain protein 1A)	5038	0.2
chr10_75596123_75596274	0.50	Gm9985	predicted gene 9985	5545	0.11
chr12_85151515_85151693	0.50	Rps6kl1	ribosomal protein S6 kinase-like 1	340	0.8
chr10_127659568_127659719	0.49	Stat6	signal transducer and activator of transcription 6	243	0.82
chr5_43032061_43032271	0.49	Gm43700	predicted gene 43700	6070	0.19
chr7_19572974_19573173	0.49	Gemin7	gem nuclear organelle associated protein 7	16	0.95
chr7_18957606_18957786	0.48	Nanos2	nanos C2HC-type zinc finger 2	29704	0.06
chr8_128491169_128491342	0.48	Nrp1	neuropilin 1	131858	0.05
chr11_100515071_100515366	0.48	Acly	ATP citrate lyase	8380	0.1
chr6_43292582_43293012	0.48	Arhgef5	Rho guanine nucleotide exchange factor (GEF) 5	9915	0.12
chr4_118247695_118247892	0.47	Ptprf	protein tyrosine phosphatase, receptor type, F	11348	0.17
chr10_75121130_75121291	0.47	Bcr	BCR activator of RhoGEF and GTPase	39150	0.15
chr16_30525931_30526082	0.47	Tmem44	transmembrane protein 44	14903	0.19
chr7_30347923_30348110	0.46	4930479H17Rik	RIKEN cDNA 4930479H17 gene	5305	0.07
chr6_118593826_118593977	0.46	Cacna1c	calcium channel, voltage-dependent, L type, alpha 1C subunit	1525	0.4
chr19_9954439_9954606	0.46	Gm50346	predicted gene, 50346	11690	0.09
chr3_81036630_81036817	0.45	Pdgfc	platelet-derived growth factor, C polypeptide	307	0.87
chr2_165969012_165969173	0.44	Gm11462	predicted gene 11462	9303	0.13
chr14_14345872_14346046	0.44	Il3ra	interleukin 3 receptor, alpha chain	316	0.78
chr13_95554131_95554549	0.44	Gm48730	predicted gene, 48730	18750	0.14
chr4_134061289_134061592	0.43	Crybg2	crystallin beta-gamma domain containing 2	625	0.58
chr10_126979601_126979791	0.43	Ctdsp2	CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2	667	0.48
chr10_77144461_77144617	0.43	Gm7775	predicted gene 7775	7439	0.19
chr8_120538960_120539167	0.43	Mir7687	microRNA 7687	367	0.7
chr7_113242447_113242773	0.42	Arntl	aryl hydrocarbon receptor nuclear translocator-like	2856	0.29
chr5_112283643_112283806	0.42	Tpst2	protein-tyrosine sulfotransferase 2	5038	0.13
chr18_80236503_80236751	0.41	Hsbp1l1	heat shock factor binding protein 1-like 1	206	0.89
chr14_70520498_70520830	0.41	Bmp1	bone morphogenetic protein 1	430	0.67
chr9_54516094_54516256	0.41	Dmxl2	Dmx-like 2	14549	0.17
chr7_44858584_44858824	0.41	Pnkp	polynucleotide kinase 3'- phosphatase	208	0.82
chr2_11365489_11365685	0.41	Gm37730	predicted gene, 37730	1864	0.2
chr6_128803059_128803375	0.41	Klrb1c	killer cell lectin-like receptor subfamily B member 1C	14002	0.09
chr19_46003413_46003585	0.41	Hps6	HPS6, biogenesis of lysosomal organelles complex 2 subunit 3	9	0.96
chr12_80001998_80002169	0.40	Gm8275	predicted gene 8275	22232	0.17
chr2_155099563_155099720	0.40	2310005A03Rik	RIKEN cDNA 2310005A03 gene	440	0.77
chr6_29272524_29272714	0.40	Hilpda	hypoxia inducible lipid droplet associated	7	0.96
chr3_101599885_101600061	0.39	Gm42941	predicted gene 42941	2843	0.23
chr2_167842569_167842745	0.39	1200007C13Rik	RIKEN cDNA 1200007C13 gene	9011	0.16
chr7_46835248_46835408	0.39	Gm45308	predicted gene 45308	2864	0.13
chr2_119742132_119742303	0.39	Itpka	inositol 1,4,5-trisphosphate 3-kinase A	120	0.91
chr9_90113472_90114008	0.39	Morf4l1	mortality factor 4 like 1	549	0.72
chr11_118211857_118212019	0.39	Cyth1	cytohesin 1	804	0.57
chr17_43327081_43327253	0.39	Adgrf5	adhesion G protein-coupled receptor F5	33284	0.19
chr14_30011884_30012221	0.38	Chdh	choline dehydrogenase	2881	0.15
chr11_96863519_96863691	0.38	Gm11524	predicted gene 11524	6590	0.09
chr11_106491531_106491682	0.38	Ern1	endoplasmic reticulum (ER) to nucleus signalling 1	3754	0.18
chr4_106980690_106980853	0.38	Ssbp3	single-stranded DNA binding protein 3	14345	0.18
chr19_3877298_3877449	0.38	Chka	choline kinase alpha	1968	0.16
chr4_150065927_150066095	0.38	Mir34a	microRNA 34a	2443	0.16
chr4_123299380_123299675	0.38	Pabpc4	poly(A) binding protein, cytoplasmic 4	2347	0.15
chr5_105826898_105827072	0.38	Lrrc8d	leucine rich repeat containing 8D	2474	0.21
chr11_101928490_101928696	0.38	Rpl27-ps2	ribosomal protein L27, pseudogene 2	10908	0.1
chr11_44405875_44406089	0.38	Il12b	interleukin 12b	5919	0.19
chr7_99699741_99699908	0.37	Slco2b1	solute carrier organic anion transporter family, member 2b1	4015	0.12
chr8_119445523_119446899	0.37	Necab2	N-terminal EF-hand calcium binding protein 2	508	0.74
chr1_86586776_86586949	0.37	Cops7b	COP9 signalosome subunit 7B	238	0.88
chr19_42551158_42551329	0.36	Gm16541	predicted gene 16541	11852	0.18
chr14_61360115_61360286	0.36	Ebpl	emopamil binding protein-like	120	0.94
chr8_124275783_124275948	0.36	Galnt2	polypeptide N-acetylgalactosaminyltransferase 2	19238	0.16
chr1_88959907_88960074	0.36	Gm4753	predicted gene 4753	27671	0.17
chr4_137769010_137769180	0.36	Alpl	alkaline phosphatase, liver/bone/kidney	520	0.8
chr10_84757574_84757782	0.35	Rfx4	regulatory factor X, 4 (influences HLA class II expression)	1616	0.43
chr5_110797818_110798001	0.35	Ulk1	unc-51 like kinase 1	2075	0.19
chr16_32246842_32247035	0.35	Fbxo45	F-box protein 45	220	0.55
chr17_17345622_17345809	0.35	Oaz1-ps	ornithine decarboxylase antizyme 1, pseudogene	425	0.8
chr9_31279892_31280066	0.35	Prdm10	PR domain containing 10	559	0.59
chr4_137824947_137825262	0.34	Alpl	alkaline phosphatase, liver/bone/kidney	28720	0.16
chr9_40628453_40628756	0.34	Gm48284	predicted gene, 48284	12218	0.12
chr7_110942267_110942426	0.34	Mrvi1	MRV integration site 1	3841	0.23
chr10_40124800_40124982	0.34	Gm25613	predicted gene, 25613	15429	0.13
chr12_108832369_108832526	0.34	Slc25a29	solute carrier family 25 (mitochondrial carrier, palmitoylcarnitine transporter), member 29	830	0.42
chr6_54070751_54070926	0.34	Chn2	chimerin 2	26882	0.18
chr15_83518459_83518650	0.34	Gm24575	predicted gene, 24575	1618	0.25
chr9_57785755_57786023	0.34	Arid3b	AT rich interactive domain 3B (BRIGHT-like)	5759	0.16
chr1_93370316_93370486	0.34	Ano7	anoctamin 7	3529	0.12
chr7_140835414_140835584	0.33	Urah	urate (5-hydroxyiso-) hydrolase	125	0.89
chr16_29944225_29944722	0.33	Gm26569	predicted gene, 26569	2043	0.31
chr16_78377023_78377174	0.33	Btg3	BTG anti-proliferation factor 3	94	0.97
chr8_70221071_70221246	0.33	Armc6	armadillo repeat containing 6	1132	0.32
chr7_83636527_83636716	0.33	Gm45838	predicted gene 45838	3250	0.14
chr2_132721307_132721479	0.33	Gm22245	predicted gene, 22245	4287	0.14
chr2_167634494_167634653	0.33	Ube2v1	ubiquitin-conjugating enzyme E2 variant 1	2478	0.16
chr3_85887151_85887500	0.32	Gm37240	predicted gene, 37240	43	0.62
chr6_31399464_31399657	0.32	Mkln1	muskelin 1, intracellular mediator containing kelch motifs	701	0.44
chr2_119355713_119355881	0.32	Chac1	ChaC, cation transport regulator 1	4568	0.16
chr11_120189789_120189958	0.32	2810410L24Rik	RIKEN cDNA 2810410L24 gene	21	0.96
chr7_141818371_141818522	0.32	Muc5b	mucin 5, subtype B, tracheobronchial	20624	0.14
chr11_97819881_97820206	0.31	Lasp1	LIM and SH3 protein 1	4795	0.1
chr6_99521816_99522204	0.31	Foxp1	forkhead box P1	637	0.76
chr9_106447373_106447582	0.31	Abhd14b	abhydrolase domain containing 14b	18	0.49
chr3_94690762_94690922	0.31	Selenbp2	selenium binding protein 2	2714	0.16
chr5_92110928_92111278	0.31	Gm24931	predicted gene, 24931	7180	0.13
chr4_3938729_3938917	0.31	Chchd7	coiled-coil-helix-coiled-coil-helix domain containing 7	65	0.84
chr15_86169783_86169988	0.31	Cerk	ceramide kinase	10417	0.17
chr13_31223115_31223275	0.30	4930401O12Rik	RIKEN cDNA 4930401O12 gene	17891	0.19
chr1_165768492_165768643	0.30	Creg1	cellular repressor of E1A-stimulated genes 1	909	0.37
chr6_121879272_121879452	0.30	Mug1	murinoglobulin 1	6215	0.21
chr18_80704875_80705052	0.30	Gm50211	predicted gene, 50211	227	0.92
chr1_61649997_61650160	0.30	Gm37205	predicted gene, 37205	4345	0.17
chr3_10284943_10285269	0.30	Fabp12	fatty acid binding protein 12	16068	0.09
chr1_119648939_119649109	0.30	Epb41l5	erythrocyte membrane protein band 4.1 like 5	24	0.97
chrX_159988087_159988260	0.30	Map3k15	mitogen-activated protein kinase kinase kinase 15	260	0.92
chr8_84656944_84657116	0.29	Ier2	immediate early response 2	5824	0.11
chr16_11006083_11006392	0.29	Gm24961	predicted gene, 24961	11851	0.1
chr16_95679759_95679918	0.29	Ets2	E26 avian leukemia oncogene 2, 3' domain	22237	0.2
chr1_87803823_87803974	0.29	Sag	S-antigen, retina and pineal gland (arrestin)	218	0.9
chr5_51511559_51511740	0.29	Gm43605	predicted gene 43605	2644	0.23
chr9_57650943_57651123	0.29	Csk	c-src tyrosine kinase	2438	0.18
chr6_124712989_124713179	0.29	Phb2	prohibitin 2	38	0.88
chr2_103713943_103714113	0.29	Abtb2	ankyrin repeat and BTB (POZ) domain containing 2	1007	0.49
chr5_139364533_139364950	0.28	Mir339	microRNA 339	5004	0.12
chr4_63252131_63252305	0.28	Mir455	microRNA 455	4633	0.19
chr2_72179596_72179778	0.28	Rapgef4	Rap guanine nucleotide exchange factor (GEF) 4	6	0.98
chr14_47472459_47472619	0.28	Fbxo34	F-box protein 34	22	0.96
chr2_167834679_167834867	0.27	1200007C13Rik	RIKEN cDNA 1200007C13 gene	1127	0.46
chr13_34742265_34742434	0.27	Fam50b	family with sequence similarity 50, member B	2737	0.19
chr13_58960766_58960939	0.27	Ntrk2	neurotrophic tyrosine kinase, receptor, type 2	89117	0.07
chr7_19797262_19797473	0.27	Cblc	Casitas B-lineage lymphoma c	558	0.52
chr9_21546507_21546700	0.27	Carm1	coactivator-associated arginine methyltransferase 1	291	0.82
chrX_20425191_20425364	0.27	Jade3	jade family PHD finger 3	411	0.81
chr4_53440081_53440358	0.27	Slc44a1	solute carrier family 44, member 1	194	0.96
chr7_127886041_127886230	0.27	Prss53	protease, serine 53	4832	0.07
chr11_5846893_5847128	0.27	Polm	polymerase (DNA directed), mu	8994	0.11
chr9_103007772_103008092	0.26	Slco2a1	solute carrier organic anion transporter family, member 2a1	70	0.97
chr9_117357124_117357284	0.26	Gm20396	predicted gene 20396	45775	0.18
chr4_133967614_133967768	0.26	Hmgn2	high mobility group nucleosomal binding domain 2	170	0.93
chr7_75762457_75762611	0.26	Gm23251	predicted gene, 23251	5166	0.17
chr7_133728557_133728948	0.26	Dhx32	DEAH (Asp-Glu-Ala-His) box polypeptide 32	2148	0.2
chr2_5669776_5669983	0.26	Camk1d	calcium/calmodulin-dependent protein kinase ID	6167	0.27
chr8_83738255_83738433	0.26	Adgre5	adhesion G protein-coupled receptor E5	2825	0.16
chr13_46888106_46888269	0.26	Gm48250	predicted gene, 48250	7160	0.15
chr9_71153822_71154046	0.26	Aqp9	aquaporin 9	8699	0.18
chr8_94186443_94186638	0.26	Gm39228	predicted gene, 39228	3251	0.13
chr15_82378546_82378931	0.26	Cyp2d22	cytochrome P450, family 2, subfamily d, polypeptide 22	1505	0.16
chr8_116581400_116581581	0.26	Dynlrb2	dynein light chain roadblock-type 2	76475	0.1
chr15_90679373_90679524	0.25	Cpne8	copine VIII	16	0.98
chr18_11205176_11205343	0.25	Gata6	GATA binding protein 6	146212	0.04
chr11_109487198_109487366	0.25	Arsg	arylsulfatase G	1676	0.26
chr2_168003768_168003979	0.25	Gm14236	predicted gene 14236	6656	0.16

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of Tfap2b

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	0.5	GO:0003162	atrioventricular node development(GO:0003162)
0.2	0.5	GO:1990705	cholangiocyte proliferation(GO:1990705)
0.2	0.5	GO:0070384	Harderian gland development(GO:0070384)
0.1	0.4	GO:1901475	pyruvate transmembrane transport(GO:1901475)
0.1	0.4	GO:0035771	interleukin-4-mediated signaling pathway(GO:0035771)
0.1	0.4	GO:0035425	autocrine signaling(GO:0035425)
0.1	0.3	GO:0018992	germ-line sex determination(GO:0018992)
0.1	0.3	GO:0003166	bundle of His development(GO:0003166)
0.1	0.4	GO:0097490	trunk segmentation(GO:0035290) trunk neural crest cell migration(GO:0036484) ventral trunk neural crest cell migration(GO:0036486) sympathetic neuron projection extension(GO:0097490) sympathetic neuron projection guidance(GO:0097491)
0.1	0.6	GO:0043951	negative regulation of cAMP-mediated signaling(GO:0043951)
0.1	0.2	GO:0009826	unidimensional cell growth(GO:0009826)
0.1	0.2	GO:0061470	T follicular helper cell differentiation(GO:0061470)
0.1	0.4	GO:0007171	activation of transmembrane receptor protein tyrosine kinase activity(GO:0007171)
0.1	0.4	GO:0019695	choline metabolic process(GO:0019695)
0.1	0.2	GO:1903261	regulation of serine phosphorylation of STAT3 protein(GO:1903261)
0.1	0.2	GO:0003419	growth plate cartilage chondrocyte proliferation(GO:0003419)
0.1	0.3	GO:0042769	DNA damage response, detection of DNA damage(GO:0042769)
0.1	0.5	GO:0006689	ganglioside catabolic process(GO:0006689)
0.1	0.3	GO:1903361	protein localization to basolateral plasma membrane(GO:1903361)
0.1	0.3	GO:1901026	ripoptosome assembly(GO:0097343) ripoptosome assembly involved in necroptotic process(GO:1901026)
0.1	0.3	GO:0070945	neutrophil mediated killing of gram-negative bacterium(GO:0070945)
0.1	0.5	GO:0048096	chromatin-mediated maintenance of transcription(GO:0048096)
0.1	0.2	GO:0071462	cellular response to water stimulus(GO:0071462)
0.0	0.2	GO:0086045	membrane depolarization during AV node cell action potential(GO:0086045)
0.0	0.2	GO:0007217	tachykinin receptor signaling pathway(GO:0007217)
0.0	0.3	GO:0015871	choline transport(GO:0015871)
0.0	0.2	GO:1904528	regulation of microtubule binding(GO:1904526) positive regulation of microtubule binding(GO:1904528)
0.0	0.1	GO:0045054	constitutive secretory pathway(GO:0045054)
0.0	0.3	GO:0042695	thelarche(GO:0042695) mammary gland branching involved in thelarche(GO:0060744)
0.0	0.1	GO:0038095	Fc-epsilon receptor signaling pathway(GO:0038095)
0.0	0.2	GO:0021914	negative regulation of smoothened signaling pathway involved in ventral spinal cord patterning(GO:0021914)
0.0	0.1	GO:0000720	pyrimidine dimer repair by nucleotide-excision repair(GO:0000720)
0.0	0.4	GO:0006020	inositol metabolic process(GO:0006020)
0.0	0.1	GO:0060066	oviduct development(GO:0060066)
0.0	0.1	GO:0098902	regulation of membrane depolarization during action potential(GO:0098902)
0.0	0.1	GO:0009597	detection of virus(GO:0009597)
0.0	0.1	GO:0060137	maternal process involved in parturition(GO:0060137)
0.0	0.1	GO:0051562	negative regulation of mitochondrial calcium ion concentration(GO:0051562)
0.0	0.1	GO:0090074	negative regulation of protein homodimerization activity(GO:0090074)
0.0	0.1	GO:0010535	positive regulation of activation of JAK2 kinase activity(GO:0010535)
0.0	0.3	GO:0010388	cullin deneddylation(GO:0010388)
0.0	0.1	GO:0071930	negative regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0071930)
0.0	0.1	GO:0015015	heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.0	0.2	GO:0006776	vitamin A metabolic process(GO:0006776)
0.0	0.2	GO:0048133	germ-line stem cell division(GO:0042078) male germ-line stem cell asymmetric division(GO:0048133) germline stem cell asymmetric division(GO:0098728)
0.0	0.1	GO:0071596	ubiquitin-dependent protein catabolic process via the N-end rule pathway(GO:0071596)
0.0	0.1	GO:0006651	diacylglycerol biosynthetic process(GO:0006651)
0.0	0.1	GO:1900739	regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900739) positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900740)
0.0	0.2	GO:0043983	histone H4-K12 acetylation(GO:0043983)
0.0	0.1	GO:2000705	regulation of dense core granule biogenesis(GO:2000705)
0.0	0.2	GO:0001561	fatty acid alpha-oxidation(GO:0001561)
0.0	0.1	GO:0034197	acylglycerol transport(GO:0034196) triglyceride transport(GO:0034197)
0.0	0.1	GO:0008050	female courtship behavior(GO:0008050)
0.0	0.1	GO:0003199	endocardial cushion to mesenchymal transition involved in heart valve formation(GO:0003199)
0.0	0.2	GO:0021800	cerebral cortex tangential migration(GO:0021800)
0.0	0.1	GO:0006987	activation of signaling protein activity involved in unfolded protein response(GO:0006987)
0.0	0.0	GO:0086046	membrane depolarization during SA node cell action potential(GO:0086046)
0.0	0.1	GO:0021564	vagus nerve development(GO:0021564)
0.0	0.1	GO:2001199	negative regulation of dendritic cell differentiation(GO:2001199)
0.0	0.0	GO:0035799	ureter maturation(GO:0035799)
0.0	0.1	GO:0060155	platelet dense granule organization(GO:0060155)
0.0	0.1	GO:1902969	mitotic DNA replication(GO:1902969)
0.0	0.1	GO:0070295	renal water absorption(GO:0070295)
0.0	0.1	GO:0001828	inner cell mass cellular morphogenesis(GO:0001828)
0.0	0.1	GO:0009202	deoxyribonucleoside triphosphate biosynthetic process(GO:0009202)
0.0	0.2	GO:2000672	negative regulation of motor neuron apoptotic process(GO:2000672)
0.0	0.1	GO:0006432	phenylalanyl-tRNA aminoacylation(GO:0006432)
0.0	0.2	GO:0032000	positive regulation of fatty acid beta-oxidation(GO:0032000)
0.0	0.1	GO:0051387	negative regulation of neurotrophin TRK receptor signaling pathway(GO:0051387)
0.0	0.1	GO:2000646	positive regulation of receptor catabolic process(GO:2000646)
0.0	0.3	GO:0043968	histone H2A acetylation(GO:0043968)
0.0	0.1	GO:0006703	estrogen biosynthetic process(GO:0006703)
0.0	0.1	GO:1902268	negative regulation of polyamine transmembrane transport(GO:1902268)
0.0	0.2	GO:0098908	regulation of neuronal action potential(GO:0098908)
0.0	0.0	GO:1902809	regulation of skeletal muscle fiber differentiation(GO:1902809)
0.0	0.0	GO:0019344	cysteine biosynthetic process(GO:0019344)
0.0	0.1	GO:0071918	urea transmembrane transport(GO:0071918)
0.0	0.1	GO:0000414	regulation of histone H3-K36 methylation(GO:0000414)
0.0	0.1	GO:1902564	negative regulation of neutrophil activation(GO:1902564)
0.0	0.1	GO:0070673	response to interleukin-18(GO:0070673)
0.0	0.5	GO:0060561	apoptotic process involved in morphogenesis(GO:0060561)
0.0	0.1	GO:0006104	succinyl-CoA metabolic process(GO:0006104)
0.0	0.1	GO:0016561	protein import into peroxisome matrix, translocation(GO:0016561)
0.0	0.3	GO:0051181	cofactor transport(GO:0051181)
0.0	0.1	GO:0015691	cadmium ion transport(GO:0015691) cadmium ion transmembrane transport(GO:0070574)
0.0	0.1	GO:0006868	glutamine transport(GO:0006868)
0.0	0.1	GO:0019249	lactate biosynthetic process from pyruvate(GO:0019244) lactate biosynthetic process(GO:0019249)
0.0	0.1	GO:0070889	platelet alpha granule organization(GO:0070889)
0.0	0.1	GO:0035542	regulation of SNARE complex assembly(GO:0035542)
0.0	0.1	GO:0002282	microglial cell activation involved in immune response(GO:0002282)
0.0	0.1	GO:1902990	mitotic telomere maintenance via semi-conservative replication(GO:1902990)
0.0	0.1	GO:0010989	negative regulation of low-density lipoprotein particle clearance(GO:0010989)
0.0	0.1	GO:0044027	hypermethylation of CpG island(GO:0044027)
0.0	0.1	GO:0019673	GDP-mannose metabolic process(GO:0019673)
0.0	0.0	GO:0042938	dipeptide transport(GO:0042938)
0.0	0.1	GO:0018242	protein O-linked glycosylation via serine(GO:0018242)
0.0	0.1	GO:0036438	maintenance of lens transparency(GO:0036438)
0.0	0.6	GO:0051693	actin filament capping(GO:0051693)
0.0	0.3	GO:0048026	positive regulation of mRNA splicing, via spliceosome(GO:0048026)
0.0	0.1	GO:0007199	G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger(GO:0007199)
0.0	0.1	GO:2000394	positive regulation of lamellipodium morphogenesis(GO:2000394)
0.0	0.1	GO:0018401	peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401)
0.0	0.0	GO:1902661	regulation of glucose mediated signaling pathway(GO:1902659) positive regulation of glucose mediated signaling pathway(GO:1902661)
0.0	0.2	GO:0033280	response to vitamin D(GO:0033280)
0.0	0.1	GO:0031944	negative regulation of glucocorticoid metabolic process(GO:0031944) negative regulation of glucocorticoid biosynthetic process(GO:0031947)
0.0	0.1	GO:0007386	compartment pattern specification(GO:0007386)
0.0	0.3	GO:0030224	monocyte differentiation(GO:0030224)
0.0	0.1	GO:0032353	negative regulation of hormone biosynthetic process(GO:0032353)
0.0	0.1	GO:0061314	Notch signaling involved in heart development(GO:0061314)
0.0	0.1	GO:0072675	osteoclast fusion(GO:0072675)
0.0	0.4	GO:0036075	endochondral ossification(GO:0001958) replacement ossification(GO:0036075)
0.0	0.0	GO:0001698	gastrin-induced gastric acid secretion(GO:0001698)
0.0	0.0	GO:0007039	protein catabolic process in the vacuole(GO:0007039)
0.0	0.2	GO:0051292	nuclear pore complex assembly(GO:0051292)
0.0	0.4	GO:0090162	establishment of epithelial cell polarity(GO:0090162)
0.0	0.0	GO:0060468	prevention of polyspermy(GO:0060468)
0.0	0.0	GO:0002432	granuloma formation(GO:0002432)
0.0	0.1	GO:0048069	eye pigmentation(GO:0048069)
0.0	0.1	GO:0001712	ectodermal cell fate commitment(GO:0001712)
0.0	0.1	GO:2000667	positive regulation of interleukin-5 secretion(GO:2000664) positive regulation of interleukin-13 secretion(GO:2000667)
0.0	0.1	GO:0002924	negative regulation of humoral immune response mediated by circulating immunoglobulin(GO:0002924)
0.0	0.1	GO:0051639	actin filament network formation(GO:0051639)
0.0	0.0	GO:0090296	regulation of mitochondrial DNA replication(GO:0090296)
0.0	0.2	GO:0001886	endothelial cell morphogenesis(GO:0001886)
0.0	0.0	GO:0051599	response to hydrostatic pressure(GO:0051599)
0.0	0.1	GO:0035459	cargo loading into vesicle(GO:0035459)
0.0	0.3	GO:0070584	mitochondrion morphogenesis(GO:0070584)
0.0	0.1	GO:0061179	negative regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0061179)
0.0	0.1	GO:0042891	antibiotic transport(GO:0042891)
0.0	0.1	GO:0051764	actin crosslink formation(GO:0051764)
0.0	0.1	GO:0034063	stress granule assembly(GO:0034063)
0.0	0.3	GO:0030318	melanocyte differentiation(GO:0030318)
0.0	0.2	GO:0097237	cellular response to toxic substance(GO:0097237)
0.0	0.1	GO:0002408	myeloid dendritic cell chemotaxis(GO:0002408)
0.0	0.2	GO:0048368	lateral mesoderm development(GO:0048368)
0.0	0.1	GO:0019934	cGMP-mediated signaling(GO:0019934)
0.0	0.0	GO:0001757	somite specification(GO:0001757)
0.0	0.1	GO:0017014	protein nitrosylation(GO:0017014)
0.0	0.0	GO:0021888	hypothalamus gonadotrophin-releasing hormone neuron differentiation(GO:0021886) hypothalamus gonadotrophin-releasing hormone neuron development(GO:0021888)
0.0	0.1	GO:0021707	cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
0.0	0.1	GO:0010457	centriole-centriole cohesion(GO:0010457)
0.0	0.1	GO:0048242	epinephrine secretion(GO:0048242)
0.0	0.0	GO:0045218	zonula adherens maintenance(GO:0045218)
0.0	0.0	GO:0072300	positive regulation of metanephric glomerulus development(GO:0072300)
0.0	0.1	GO:0046415	urate metabolic process(GO:0046415)
0.0	0.0	GO:0051344	negative regulation of cyclic-nucleotide phosphodiesterase activity(GO:0051344)
0.0	0.0	GO:0048696	regulation of collateral sprouting in absence of injury(GO:0048696)
0.0	0.1	GO:0009437	carnitine metabolic process(GO:0009437)
0.0	0.1	GO:0010815	bradykinin catabolic process(GO:0010815)
0.0	0.2	GO:0061036	positive regulation of cartilage development(GO:0061036)
0.0	0.0	GO:0071332	cellular response to fructose stimulus(GO:0071332)
0.0	0.1	GO:0009115	xanthine catabolic process(GO:0009115)
0.0	0.0	GO:0006015	5-phosphoribose 1-diphosphate biosynthetic process(GO:0006015) 5-phosphoribose 1-diphosphate metabolic process(GO:0046391)
0.0	0.0	GO:2001046	positive regulation of integrin-mediated signaling pathway(GO:2001046)
0.0	0.1	GO:0060267	positive regulation of respiratory burst(GO:0060267)
0.0	0.0	GO:2001286	regulation of caveolin-mediated endocytosis(GO:2001286)
0.0	0.0	GO:0051684	maintenance of Golgi location(GO:0051684)
0.0	0.0	GO:0061642	chemoattraction of axon(GO:0061642)
0.0	0.1	GO:0043031	negative regulation of macrophage activation(GO:0043031)
0.0	0.0	GO:0061687	detoxification of inorganic compound(GO:0061687)
0.0	0.1	GO:0019852	L-ascorbic acid metabolic process(GO:0019852)
0.0	0.1	GO:0021999	neural plate anterior/posterior regionalization(GO:0021999) neural plate regionalization(GO:0060897)
0.0	0.1	GO:1903608	protein localization to cytoplasmic stress granule(GO:1903608)
0.0	0.3	GO:0043252	sodium-independent organic anion transport(GO:0043252)
0.0	0.1	GO:0035188	blastocyst hatching(GO:0001835) hatching(GO:0035188) organism emergence from protective structure(GO:0071684)
0.0	0.0	GO:0018894	dibenzo-p-dioxin metabolic process(GO:0018894)
0.0	0.0	GO:0070885	negative regulation of calcineurin-NFAT signaling cascade(GO:0070885)
0.0	0.0	GO:0061052	negative regulation of cell growth involved in cardiac muscle cell development(GO:0061052)
0.0	0.1	GO:1900746	regulation of vascular endothelial growth factor signaling pathway(GO:1900746)
0.0	0.0	GO:0007494	midgut development(GO:0007494)
0.0	0.0	GO:0035087	siRNA loading onto RISC involved in RNA interference(GO:0035087)
0.0	0.0	GO:0035887	aortic smooth muscle cell differentiation(GO:0035887)
0.0	0.0	GO:2000574	regulation of microtubule motor activity(GO:2000574)
0.0	0.1	GO:0007175	negative regulation of epidermal growth factor-activated receptor activity(GO:0007175)
0.0	0.0	GO:0043133	hindgut contraction(GO:0043133) regulation of hindgut contraction(GO:0043134)
0.0	0.0	GO:0061589	calcium activated phosphatidylserine scrambling(GO:0061589)
0.0	0.0	GO:0031086	nuclear-transcribed mRNA catabolic process, deadenylation-independent decay(GO:0031086) deadenylation-independent decapping of nuclear-transcribed mRNA(GO:0031087)
0.0	0.0	GO:0051890	regulation of cardioblast differentiation(GO:0051890)
0.0	0.0	GO:0044838	cell quiescence(GO:0044838)
0.0	0.2	GO:0001522	pseudouridine synthesis(GO:0001522)
0.0	0.1	GO:0051547	regulation of keratinocyte migration(GO:0051547) positive regulation of keratinocyte migration(GO:0051549)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	0.5	GO:0002193	MAML1-RBP-Jkappa- ICN1 complex(GO:0002193)
0.1	0.6	GO:0008091	spectrin(GO:0008091)
0.1	0.6	GO:0031931	TORC1 complex(GO:0031931)
0.1	0.2	GO:0030981	cortical microtubule cytoskeleton(GO:0030981)
0.0	0.1	GO:0097443	sorting endosome(GO:0097443)
0.0	0.1	GO:0031084	BLOC-2 complex(GO:0031084)
0.0	0.1	GO:0031092	platelet alpha granule membrane(GO:0031092)
0.0	0.5	GO:0032797	SMN complex(GO:0032797)
0.0	0.4	GO:0005766	primary lysosome(GO:0005766) azurophil granule(GO:0042582)
0.0	0.1	GO:0000811	GINS complex(GO:0000811)
0.0	0.2	GO:1990454	L-type voltage-gated calcium channel complex(GO:1990454)
0.0	0.1	GO:0038037	G-protein coupled receptor dimeric complex(GO:0038037) G-protein coupled receptor complex(GO:0097648)
0.0	0.1	GO:0044316	cone cell pedicle(GO:0044316)
0.0	0.3	GO:0065010	extracellular membrane-bounded organelle(GO:0065010)
0.0	0.5	GO:0005721	pericentric heterochromatin(GO:0005721)
0.0	0.1	GO:0035189	Rb-E2F complex(GO:0035189)
0.0	0.1	GO:0033553	rDNA heterochromatin(GO:0033553)
0.0	0.1	GO:0097255	R2TP complex(GO:0097255)
0.0	0.2	GO:0097542	ciliary tip(GO:0097542)
0.0	0.1	GO:0000322	storage vacuole(GO:0000322)
0.0	0.1	GO:1990597	AIP1-IRE1 complex(GO:1990597)
0.0	0.3	GO:0016580	Sin3 complex(GO:0016580)
0.0	0.2	GO:0098563	integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.0	0.0	GO:0036488	CHOP-C/EBP complex(GO:0036488)
0.0	0.1	GO:0097629	extrinsic component of omegasome membrane(GO:0097629)
0.0	0.2	GO:0043219	lateral loop(GO:0043219)
0.0	0.1	GO:0030062	mitochondrial tricarboxylic acid cycle enzyme complex(GO:0030062)
0.0	0.2	GO:0061700	GATOR2 complex(GO:0061700)
0.0	0.1	GO:0005796	Golgi lumen(GO:0005796)
0.0	0.1	GO:0019815	B cell receptor complex(GO:0019815)
0.0	0.1	GO:0005579	membrane attack complex(GO:0005579)
0.0	0.1	GO:0031080	nuclear pore outer ring(GO:0031080)
0.0	0.1	GO:0097197	tetraspanin-enriched microdomain(GO:0097197)
0.0	0.1	GO:0097418	neurofibrillary tangle(GO:0097418)
0.0	0.0	GO:0097513	myosin II filament(GO:0097513)
0.0	0.1	GO:0042105	alpha-beta T cell receptor complex(GO:0042105)
0.0	0.1	GO:0016281	eukaryotic translation initiation factor 4F complex(GO:0016281)
0.0	0.1	GO:0031264	death-inducing signaling complex(GO:0031264)
0.0	0.5	GO:0001917	photoreceptor inner segment(GO:0001917)
0.0	0.0	GO:0044354	pinosome(GO:0044352) macropinosome(GO:0044354)
0.0	0.1	GO:0000235	astral microtubule(GO:0000235)
0.0	0.1	GO:0042555	MCM complex(GO:0042555)
0.0	0.4	GO:0031901	early endosome membrane(GO:0031901)
0.0	0.3	GO:0005834	heterotrimeric G-protein complex(GO:0005834)
0.0	0.1	GO:0044232	organelle membrane contact site(GO:0044232)
0.0	0.1	GO:0045180	basal cortex(GO:0045180)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	0.5	GO:0001031	RNA polymerase III type 1 promoter DNA binding(GO:0001030) RNA polymerase III type 2 promoter DNA binding(GO:0001031) RNA polymerase III type 3 promoter DNA binding(GO:0001032) 5S rDNA binding(GO:0080084)
0.1	0.4	GO:0050833	pyruvate transmembrane transporter activity(GO:0050833)
0.1	0.3	GO:0051733	ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity(GO:0046404) polydeoxyribonucleotide kinase activity(GO:0051733)
0.1	0.3	GO:0004104	cholinesterase activity(GO:0004104)
0.1	0.7	GO:0034560	3-(3-hydroxyphenyl)propionate hydroxylase activity(GO:0008688) 4-chlorobenzaldehyde oxidase activity(GO:0018471) 3,5-xylenol methylhydroxylase activity(GO:0018630) phenylacetate hydroxylase activity(GO:0018631) 4-nitrophenol 4-monooxygenase activity(GO:0018632) dimethyl sulfide monooxygenase activity(GO:0018633) alpha-pinene monooxygenase [NADH] activity(GO:0018634) 1-hydroxy-2-naphthoate hydroxylase activity(GO:0018637) toluene 4-monooxygenase activity(GO:0018638) xylene monooxygenase activity(GO:0018639) dibenzothiophene monooxygenase activity(GO:0018640) 6-hydroxy-3-methyl-2-oxo-1,2-dihydroquinoline 6-monooxygenase activity(GO:0018641) chlorophenol 4-monooxygenase activity(GO:0018642) carbon disulfide oxygenase activity(GO:0018643) toluene 2-monooxygenase activity(GO:0018644) 1-hydroxy-2-oxolimonene 1,2-monooxygenase activity(GO:0018646) phenanthrene 1,2-monooxygenase activity(GO:0018647) tetrahydrofuran hydroxylase activity(GO:0018649) styrene monooxygenase activity(GO:0018650) toluene-4-sulfonate monooxygenase activity(GO:0018651) toluene-sulfonate methyl-monooxygenase activity(GO:0018652) 3-methyl-2-oxo-1,2-dihydroquinoline 6-monooxygenase activity(GO:0018653) 2-hydroxy-phenylacetate hydroxylase activity(GO:0018654) 2-oxo-delta3-4,5,5-trimethylcyclopentenylacetyl-CoA 1,2-monooxygenase activity(GO:0018655) phenanthrene 3,4-monooxygenase activity(GO:0018656) toluene 3-monooxygenase activity(GO:0018657) 4-hydroxyphenylacetate,NADH:oxygen oxidoreductase (3-hydroxylating) activity(GO:0018660) limonene monooxygenase activity(GO:0019113) 2-methylnaphthalene hydroxylase activity(GO:0034526) 1-methylnaphthalene hydroxylase activity(GO:0034534) bisphenol A hydroxylase A activity(GO:0034560) salicylate 5-hydroxylase activity(GO:0034785) isobutylamine N-hydroxylase activity(GO:0034791) branched-chain dodecylbenzene sulfonate monooxygenase activity(GO:0034802) 3-HSA hydroxylase activity(GO:0034819) 4-hydroxypyridine-3-hydroxylase activity(GO:0034894) 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase activity(GO:0043719) 6-hydroxynicotinate 3-monooxygenase activity(GO:0043731) thalianol hydroxylase activity(GO:0080014)
0.1	0.5	GO:0004563	beta-N-acetylhexosaminidase activity(GO:0004563)
0.1	0.3	GO:0004035	alkaline phosphatase activity(GO:0004035)
0.1	0.3	GO:0097016	L27 domain binding(GO:0097016)
0.1	0.2	GO:0043533	inositol 1,3,4,5 tetrakisphosphate binding(GO:0043533)
0.1	0.3	GO:0002046	opsin binding(GO:0002046)
0.1	0.3	GO:0015220	choline transmembrane transporter activity(GO:0015220)
0.1	0.2	GO:0086056	voltage-gated calcium channel activity involved in AV node cell action potential(GO:0086056)
0.1	0.5	GO:0048027	mRNA 5'-UTR binding(GO:0048027)
0.1	0.4	GO:0003708	retinoic acid receptor activity(GO:0003708)
0.1	0.2	GO:0004703	G-protein coupled receptor kinase activity(GO:0004703)
0.1	0.4	GO:0008440	inositol-1,4,5-trisphosphate 3-kinase activity(GO:0008440)
0.1	0.2	GO:0043398	HLH domain binding(GO:0043398)
0.1	0.2	GO:0032767	copper-dependent protein binding(GO:0032767)
0.0	0.1	GO:0004699	calcium-independent protein kinase C activity(GO:0004699)
0.0	0.1	GO:0005001	transmembrane receptor protein tyrosine phosphatase activity(GO:0005001)
0.0	0.2	GO:0070051	fibrinogen binding(GO:0070051)
0.0	0.9	GO:0030506	ankyrin binding(GO:0030506)
0.0	0.6	GO:0070577	lysine-acetylated histone binding(GO:0070577)
0.0	0.2	GO:0070891	lipoteichoic acid binding(GO:0070891)
0.0	0.6	GO:0016863	intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)
0.0	0.1	GO:0004965	G-protein coupled GABA receptor activity(GO:0004965)
0.0	0.2	GO:0008420	CTD phosphatase activity(GO:0008420)
0.0	0.1	GO:0017162	aryl hydrocarbon receptor binding(GO:0017162)
0.0	0.3	GO:0038191	neuropilin binding(GO:0038191)
0.0	0.1	GO:0017153	sodium:dicarboxylate symporter activity(GO:0017153)
0.0	0.4	GO:0005161	platelet-derived growth factor receptor binding(GO:0005161)
0.0	0.2	GO:1990380	Lys48-specific deubiquitinase activity(GO:1990380)
0.0	0.1	GO:0042895	antibiotic transporter activity(GO:0042895)
0.0	0.1	GO:0060230	lipoprotein lipase activator activity(GO:0060230)
0.0	0.4	GO:0008601	protein phosphatase type 2A regulator activity(GO:0008601)
0.0	0.2	GO:0047035	testosterone dehydrogenase (NAD+) activity(GO:0047035)
0.0	0.2	GO:0005078	MAP-kinase scaffold activity(GO:0005078)
0.0	0.1	GO:0003846	2-acylglycerol O-acyltransferase activity(GO:0003846)
0.0	0.2	GO:0001091	RNA polymerase II basal transcription factor binding(GO:0001091)
0.0	0.1	GO:0038085	vascular endothelial growth factor binding(GO:0038085)
0.0	0.1	GO:0036374	gamma-glutamyltransferase activity(GO:0003840) glutathione hydrolase activity(GO:0036374)
0.0	0.1	GO:0017169	CDP-alcohol phosphatidyltransferase activity(GO:0017169)
0.0	0.2	GO:0015651	quaternary ammonium group transmembrane transporter activity(GO:0015651)
0.0	0.2	GO:0034943	3-oxo-2-(2'-pentenyl)cyclopentane-1-octanoic acid CoA ligase activity(GO:0010435) 3-isopropenyl-6-oxoheptanoyl-CoA synthetase activity(GO:0018854) 2-oxo-delta3-4,5,5-trimethylcyclopentenylacetyl-CoA synthetase activity(GO:0018855) benzoyl acetate-CoA ligase activity(GO:0018856) 2,4-dichlorobenzoate-CoA ligase activity(GO:0018857) pivalate-CoA ligase activity(GO:0034783) cyclopropanecarboxylate-CoA ligase activity(GO:0034793) adipate-CoA ligase activity(GO:0034796) citronellyl-CoA ligase activity(GO:0034823) mentha-1,3-dione-CoA ligase activity(GO:0034841) thiophene-2-carboxylate-CoA ligase activity(GO:0034842) 2,4,4-trimethylpentanoate-CoA ligase activity(GO:0034865) cis-2-methyl-5-isopropylhexa-2,5-dienoate-CoA ligase activity(GO:0034942) trans-2-methyl-5-isopropylhexa-2,5-dienoate-CoA ligase activity(GO:0034943) branched-chain acyl-CoA synthetase (ADP-forming) activity(GO:0043759) aryl-CoA synthetase (ADP-forming) activity(GO:0043762) 3-hydroxypropionyl-CoA synthetase activity(GO:0043955) perillic acid:CoA ligase (ADP-forming) activity(GO:0052685) perillic acid:CoA ligase (AMP-forming) activity(GO:0052686) (3R)-3-isopropenyl-6-oxoheptanoate:CoA ligase (ADP-forming) activity(GO:0052687) (3R)-3-isopropenyl-6-oxoheptanoate:CoA ligase (AMP-forming) activity(GO:0052688) pristanate-CoA ligase activity(GO:0070251) malonyl-CoA synthetase activity(GO:0090409)
0.0	0.1	GO:0008073	ornithine decarboxylase inhibitor activity(GO:0008073)
0.0	0.1	GO:0016649	electron-transferring-flavoprotein dehydrogenase activity(GO:0004174) oxidoreductase activity, acting on the CH-NH group of donors, quinone or similar compound as acceptor(GO:0016649)
0.0	0.1	GO:0004739	pyruvate dehydrogenase (acetyl-transferring) activity(GO:0004739)
0.0	0.1	GO:0005345	purine nucleobase transmembrane transporter activity(GO:0005345) pyrimidine nucleobase transmembrane transporter activity(GO:0005350) nucleobase transmembrane transporter activity(GO:0015205)
0.0	0.1	GO:0035615	clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)
0.0	0.1	GO:0005049	nuclear export signal receptor activity(GO:0005049)
0.0	0.1	GO:0015288	porin activity(GO:0015288)
0.0	0.1	GO:0015057	thrombin receptor activity(GO:0015057)
0.0	0.1	GO:0015182	L-asparagine transmembrane transporter activity(GO:0015182) L-glutamine transmembrane transporter activity(GO:0015186)
0.0	0.1	GO:0004459	L-lactate dehydrogenase activity(GO:0004459)
0.0	0.1	GO:0004826	phenylalanine-tRNA ligase activity(GO:0004826)
0.0	0.2	GO:0051010	microtubule plus-end binding(GO:0051010)
0.0	0.1	GO:0004719	protein-L-isoaspartate (D-aspartate) O-methyltransferase activity(GO:0004719)
0.0	0.4	GO:0030742	GTP-dependent protein binding(GO:0030742)
0.0	0.1	GO:0008454	alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.0	0.3	GO:0004709	MAP kinase kinase kinase activity(GO:0004709)
0.0	0.1	GO:0016971	flavin-linked sulfhydryl oxidase activity(GO:0016971)
0.0	0.1	GO:0008545	JUN kinase kinase activity(GO:0008545)
0.0	0.1	GO:0019145	aminobutyraldehyde dehydrogenase activity(GO:0019145) 4-trimethylammoniobutyraldehyde dehydrogenase activity(GO:0047105)
0.0	0.1	GO:0033829	O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
0.0	0.1	GO:0015087	cobalt ion transmembrane transporter activity(GO:0015087)
0.0	0.0	GO:0071535	RING-like zinc finger domain binding(GO:0071535)
0.0	0.1	GO:0046912	transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
0.0	0.6	GO:0042605	peptide antigen binding(GO:0042605)
0.0	0.1	GO:0008349	MAP kinase kinase kinase kinase activity(GO:0008349)
0.0	0.1	GO:0030550	acetylcholine receptor inhibitor activity(GO:0030550)
0.0	0.1	GO:0005143	interleukin-12 receptor binding(GO:0005143)
0.0	0.2	GO:0019841	retinol binding(GO:0019841)
0.0	0.1	GO:0004031	aldehyde oxidase activity(GO:0004031) oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor(GO:0016623)
0.0	0.1	GO:0016176	superoxide-generating NADPH oxidase activator activity(GO:0016176)
0.0	0.1	GO:0046624	sphingolipid transporter activity(GO:0046624)
0.0	0.1	GO:0015245	fatty acid transporter activity(GO:0015245)
0.0	0.1	GO:0015173	aromatic amino acid transmembrane transporter activity(GO:0015173)
0.0	0.1	GO:0048019	receptor antagonist activity(GO:0048019)
0.0	0.0	GO:0071209	U7 snRNA binding(GO:0071209)
0.0	0.1	GO:0008517	folic acid transporter activity(GO:0008517)
0.0	0.0	GO:0004920	interleukin-10 receptor activity(GO:0004920)
0.0	0.1	GO:0035613	RNA stem-loop binding(GO:0035613)
0.0	0.1	GO:0031545	peptidyl-proline 4-dioxygenase activity(GO:0031545)
0.0	0.0	GO:0070840	dynein complex binding(GO:0070840)
0.0	0.2	GO:0009982	pseudouridine synthase activity(GO:0009982)
0.0	0.1	GO:0032052	bile acid binding(GO:0032052)
0.0	0.1	GO:0000268	peroxisome targeting sequence binding(GO:0000268)
0.0	0.1	GO:0031996	thioesterase binding(GO:0031996)
0.0	0.0	GO:0015143	urate transmembrane transporter activity(GO:0015143) salt transmembrane transporter activity(GO:1901702)
0.0	0.1	GO:0086080	protein binding involved in heterotypic cell-cell adhesion(GO:0086080)
0.0	0.0	GO:0004969	histamine receptor activity(GO:0004969)
0.0	0.1	GO:0042301	phosphate ion binding(GO:0042301)
0.0	0.0	GO:0015038	glutathione disulfide oxidoreductase activity(GO:0015038)
0.0	0.2	GO:0070064	proline-rich region binding(GO:0070064)
0.0	0.2	GO:0003785	actin monomer binding(GO:0003785)
0.0	0.0	GO:1990430	extracellular matrix protein binding(GO:1990430)
0.0	0.1	GO:0010181	FMN binding(GO:0010181)
0.0	0.1	GO:0016813	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.0	0.2	GO:0035259	glucocorticoid receptor binding(GO:0035259)
0.0	0.1	GO:0008190	eukaryotic initiation factor 4E binding(GO:0008190)
0.0	0.0	GO:0004887	thyroid hormone receptor activity(GO:0004887)
0.0	0.3	GO:0052771	coenzyme F390-A hydrolase activity(GO:0052770) coenzyme F390-G hydrolase activity(GO:0052771)
0.0	0.1	GO:0030274	LIM domain binding(GO:0030274)
0.0	0.0	GO:0004720	protein-lysine 6-oxidase activity(GO:0004720)
0.0	0.1	GO:0016443	bidentate ribonuclease III activity(GO:0016443)
0.0	0.0	GO:0019961	interferon binding(GO:0019961)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.2	SA TRKA RECEPTOR	The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.
0.1	0.1	ST DIFFERENTIATION PATHWAY IN PC12 CELLS	Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway.
0.0	0.3	ST PAC1 RECEPTOR PATHWAY	PAC1 Receptor Pathway
0.0	0.2	PID AJDISS 2PATHWAY	Posttranslational regulation of adherens junction stability and dissassembly
0.0	0.4	PID DNA PK PATHWAY	DNA-PK pathway in nonhomologous end joining
0.0	0.5	PID RHODOPSIN PATHWAY	Visual signal transduction: Rods
0.0	0.1	PID VEGF VEGFR PATHWAY	VEGF and VEGFR signaling network
0.0	0.2	PID TCR JNK PATHWAY	JNK signaling in the CD4+ TCR pathway
0.0	0.0	PID GMCSF PATHWAY	GMCSF-mediated signaling events
0.0	0.5	PID HIF2PATHWAY	HIF-2-alpha transcription factor network
0.0	0.8	PID IL12 2PATHWAY	IL12-mediated signaling events
0.0	0.3	PID RXR VDR PATHWAY	RXR and RAR heterodimerization with other nuclear receptor
0.0	0.1	PID IL5 PATHWAY	IL5-mediated signaling events
0.0	0.5	PID HES HEY PATHWAY	Notch-mediated HES/HEY network
0.0	0.1	PID AURORA A PATHWAY	Aurora A signaling
0.0	0.4	PID CDC42 REG PATHWAY	Regulation of CDC42 activity
0.0	0.2	PID LPA4 PATHWAY	LPA4-mediated signaling events
0.0	0.3	PID EPHRINB REV PATHWAY	Ephrin B reverse signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.6	REACTOME MTORC1 MEDIATED SIGNALLING	Genes involved in mTORC1-mediated signalling
0.1	0.5	REACTOME VEGF LIGAND RECEPTOR INTERACTIONS	Genes involved in VEGF ligand-receptor interactions
0.1	0.6	REACTOME NOTCH HLH TRANSCRIPTION PATHWAY	Genes involved in Notch-HLH transcription pathway
0.0	0.5	REACTOME HYALURONAN UPTAKE AND DEGRADATION	Genes involved in Hyaluronan uptake and degradation
0.0	0.5	REACTOME INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1	Genes involved in Inhibition of replication initiation of damaged DNA by RB1/E2F1
0.0	0.3	REACTOME TRANSPORT OF ORGANIC ANIONS	Genes involved in Transport of organic anions
0.0	0.7	REACTOME SYNTHESIS OF PC	Genes involved in Synthesis of PC
0.0	0.6	REACTOME INTERACTION BETWEEN L1 AND ANKYRINS	Genes involved in Interaction between L1 and Ankyrins
0.0	0.1	REACTOME XENOBIOTICS	Genes involved in Xenobiotics
0.0	0.2	REACTOME NFKB ACTIVATION THROUGH FADD RIP1 PATHWAY MEDIATED BY CASPASE 8 AND10	Genes involved in NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
0.0	0.3	REACTOME P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS	Genes involved in p130Cas linkage to MAPK signaling for integrins
0.0	0.2	REACTOME PASSIVE TRANSPORT BY AQUAPORINS	Genes involved in Passive Transport by Aquaporins
0.0	0.2	REACTOME GABA A RECEPTOR ACTIVATION	Genes involved in GABA A receptor activation
0.0	0.2	REACTOME UNWINDING OF DNA	Genes involved in Unwinding of DNA
0.0	0.2	REACTOME NOD1 2 SIGNALING PATHWAY	Genes involved in NOD1/2 Signaling Pathway
0.0	0.2	REACTOME RAP1 SIGNALLING	Genes involved in Rap1 signalling
0.0	0.0	REACTOME DESTABILIZATION OF MRNA BY BRF1	Genes involved in Destabilization of mRNA by Butyrate Response Factor 1 (BRF1)
0.0	0.2	REACTOME JNK C JUN KINASES PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1	Genes involved in JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
0.0	0.0	REACTOME GPVI MEDIATED ACTIVATION CASCADE	Genes involved in GPVI-mediated activation cascade
0.0	0.1	REACTOME PD1 SIGNALING	Genes involved in PD-1 signaling
0.0	0.3	REACTOME GLUTATHIONE CONJUGATION	Genes involved in Glutathione conjugation
0.0	0.6	REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY	Genes involved in Nuclear Receptor transcription pathway
0.0	0.1	REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION	Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.0	0.2	REACTOME EFFECTS OF PIP2 HYDROLYSIS	Genes involved in Effects of PIP2 hydrolysis
0.0	0.1	REACTOME IKK COMPLEX RECRUITMENT MEDIATED BY RIP1	Genes involved in IKK complex recruitment mediated by RIP1
0.0	0.3	REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS	Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits