Project

ENCSR904DTN: DNase-seq of mouse liver in constant darkness

Navigation

Downloads

CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for Tfap2e

Z-value: 0.71

Motif logo

Transcription factors associated with Tfap2e

Gene Symbol	Gene ID	Gene Info
Tfap2e Ensembl NCBI MGI UniProt	ENSMUSG00000042477.7	Tfap2e

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

Gene	Promoter	Distance	Association probability	Pearson corr. coef.	P-value	Plot
Tfap2e	chr4_126733083_126733252	3073	0.181558	0.71	1.1e-01	Click!
Tfap2e	chr4_126708617_126708772	27546	0.107511	0.69	1.3e-01	Click!
Tfap2e	chr4_126741521_126741686	5363	0.143797	0.07	8.9e-01	Click!

Activity of the Tfap2e motif across conditions

Conditions sorted by the z-value of the Tfap2e motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr6_116636671_116636829	0.65	Rassf4	Ras association (RalGDS/AF-6) domain family member 4	4252	0.12
chr12_112109668_112109994	0.58	Mir3073b	microRNA 3073b	522	0.45
chr2_29750814_29750965	0.53	Gm13420	predicted gene 13420	796	0.47
chr13_54402403_54402557	0.43	Gm16248	predicted gene 16248	3146	0.22
chr9_115456234_115456417	0.43	Gm5921	predicted gene 5921	17744	0.16
chr11_94390636_94390799	0.43	Abcc3	ATP-binding cassette, sub-family C (CFTR/MRP), member 3	2203	0.26
chr17_56681920_56682093	0.39	Ranbp3	RAN binding protein 3	8622	0.11
chr2_145813125_145813276	0.38	Rin2	Ras and Rab interactor 2	8950	0.22
chr19_54071291_54071462	0.38	Gm50186	predicted gene, 50186	13183	0.18
chr3_108782866_108783017	0.37	Stxbp3	syntaxin binding protein 3	14843	0.14
chr5_117285355_117285646	0.33	Pebp1	phosphatidylethanolamine binding protein 1	2025	0.19
chr12_102295217_102295408	0.33	Rin3	Ras and Rab interactor 3	11671	0.22
chr13_32897014_32897418	0.30	Serpinb1c	serine (or cysteine) peptidase inhibitor, clade B, member 1c	941	0.49
chr1_72833711_72833862	0.30	Igfbp2	insulin-like growth factor binding protein 2	8464	0.22
chr19_25387114_25387309	0.30	Kank1	KN motif and ankyrin repeat domains 1	8092	0.22
chr17_29045019_29045203	0.29	Srsf3	serine and arginine-rich splicing factor 3	5417	0.09
chr10_80957966_80958144	0.28	Gm3828	predicted gene 3828	3345	0.13
chr9_95580937_95581120	0.28	Paqr9	progestin and adipoQ receptor family member IX	21371	0.11
chr11_64599304_64599471	0.27	Gm24275	predicted gene, 24275	8747	0.3
chr12_110992829_110992984	0.26	6030440G07Rik	RIKEN cDNA 6030440G07 gene	1492	0.27
chr19_34772591_34773080	0.26	Gm50173	predicted gene, 50173	1046	0.4
chr19_30331979_30332136	0.26	Gm24108	predicted gene, 24108	70540	0.11
chr2_39003650_39003831	0.26	Rpl35	ribosomal protein L35	1303	0.23
chr6_73221980_73222151	0.26	Dnah6	dynein, axonemal, heavy chain 6	414	0.72
chr11_53419604_53419795	0.26	Leap2	liver-expressed antimicrobial peptide 2	3471	0.1
chr12_102437143_102437359	0.25	Lgmn	legumain	2562	0.25
chr16_18877584_18877767	0.25	Hira	histone cell cycle regulator	263	0.79
chr14_61037704_61037855	0.24	Tnfrsf19	tumor necrosis factor receptor superfamily, member 19	112	0.6
chr2_153657078_153657257	0.24	Dnmt3bos	DNA methyltransferase 3B, opposite strand	6881	0.16
chr16_23989631_23990067	0.23	Bcl6	B cell leukemia/lymphoma 6	997	0.42
chr18_46716349_46716534	0.23	Cdo1	cysteine dioxygenase 1, cytosolic	11588	0.13
chr9_67614466_67614621	0.22	Tln2	talin 2	54840	0.12
chr5_114889052_114889221	0.22	Oasl2	2'-5' oligoadenylate synthetase-like 2	7800	0.08
chr2_129489606_129489767	0.22	Gm14040	predicted gene 14040	26121	0.15
chr4_59548512_59548664	0.21	Ptbp3	polypyrimidine tract binding protein 3	149	0.84
chr7_84167720_84167916	0.20	Gm22177	predicted gene, 22177	2747	0.21
chr1_39591675_39591839	0.20	Gm5100	predicted gene 5100	6248	0.13
chr2_154609281_154609723	0.20	Zfp341	zinc finger protein 341	3795	0.12
chr12_84206331_84206483	0.20	Gm47447	predicted gene, 47447	9730	0.1
chr11_61564668_61564834	0.20	Epn2	epsin 2	14907	0.14
chr5_9043706_9043857	0.20	Gm40264	predicted gene, 40264	8657	0.15
chr16_95827519_95827681	0.20	1600002D24Rik	RIKEN cDNA 1600002D24 gene	18170	0.16
chr13_92469480_92469792	0.19	Fam151b	family with sequence similarity 151, member B	14377	0.17
chr1_165768492_165768643	0.19	Creg1	cellular repressor of E1A-stimulated genes 1	909	0.37
chr17_63493519_63493696	0.19	Fbxl17	F-box and leucine-rich repeat protein 17	854	0.7
chr9_70657719_70657882	0.19	Mindy2	MINDY lysine 48 deubiquitinase 2	626	0.63
chr4_31426757_31426908	0.19	Gm11922	predicted gene 11922	46360	0.2
chr8_71680518_71680684	0.19	Jak3	Janus kinase 3	2266	0.14
chr3_145780988_145781495	0.18	Ddah1	dimethylarginine dimethylaminohydrolase 1	20493	0.19
chr19_41911790_41911957	0.18	Pgam1	phosphoglycerate mutase 1	50	0.95
chr5_138779730_138779904	0.18	Fam20c	family with sequence similarity 20, member C	6683	0.2
chr10_94119877_94120030	0.18	Gm48372	predicted gene, 48372	11214	0.13
chr1_190174350_190174513	0.17	Prox1	prospero homeobox 1	3717	0.22
chr19_34804924_34805353	0.17	Gm50116	predicted gene, 50116	876	0.48
chr19_12634142_12634556	0.17	Glyat	glycine-N-acyltransferase	816	0.44
chr19_6952737_6952905	0.17	Plcb3	phospholipase C, beta 3	2026	0.12
chr14_73382885_73383301	0.17	Itm2b	integral membrane protein 2B	2105	0.33
chr13_60493839_60494263	0.17	A530001N23Rik	RIKEN cDNA A530001N23 gene	5243	0.18
chr5_88929617_88929827	0.17	Slc4a4	solute carrier family 4 (anion exchanger), member 4	4810	0.28
chr18_46698271_46698422	0.17	Cdo1	cysteine dioxygenase 1, cytosolic	29683	0.11
chr5_32092059_32092277	0.17	Babam2	BRISC and BRCA1 A complex member 2	12471	0.17
chr9_33068372_33068541	0.16	Gm27166	predicted gene 27166	36665	0.17
chr19_4821405_4821565	0.16	Ccs	copper chaperone for superoxide dismutase	4524	0.09
chr3_95625229_95625406	0.16	Ensa	endosulfine alpha	291	0.8
chr18_31884190_31884397	0.16	Wdr33	WD repeat domain 33	2151	0.25
chr10_84811233_84811541	0.16	Gm24226	predicted gene, 24226	204	0.95
chr2_148872952_148873130	0.16	Cst3	cystatin C	2410	0.19
chr5_122274917_122275081	0.16	Pptc7	PTC7 protein phosphatase homolog	9366	0.11
chr18_12647726_12648094	0.15	Gm41668	predicted gene, 41668	509	0.72
chr3_83994327_83994478	0.15	Tmem131l	transmembrane 131 like	26174	0.21
chr12_71719042_71719430	0.15	Gm47555	predicted gene, 47555	35149	0.17
chr2_119355713_119355881	0.15	Chac1	ChaC, cation transport regulator 1	4568	0.16
chr9_51961247_51961723	0.15	Fdx1	ferredoxin 1	2061	0.29
chr10_7212691_7212859	0.15	Cnksr3	Cnksr family member 3	538	0.86
chr10_77693450_77693640	0.15	Gm19402	predicted gene, 19402	2788	0.08
chr5_99994276_99994439	0.15	Gm17092	predicted gene 17092	15296	0.13
chr12_78265748_78266376	0.15	Gm48225	predicted gene, 48225	4769	0.18
chr10_75222636_75222997	0.15	Specc1l	sperm antigen with calponin homology and coiled-coil domains 1-like	7039	0.21
chr13_46883271_46883538	0.15	Gm48250	predicted gene, 48250	2377	0.23
chr9_43467006_43467175	0.15	Gm28215	predicted gene 28215	2332	0.29
chr6_117612056_117612213	0.15	Gm45083	predicted gene 45083	436	0.85
chr14_20298249_20298415	0.14	Nudt13	nudix (nucleoside diphosphate linked moiety X)-type motif 13	2170	0.22
chr17_25221206_25221426	0.14	Unkl	unkempt family like zinc finger	1223	0.25
chr4_57845057_57845232	0.14	Pakap	paralemmin A kinase anchor protein	103	0.97
chr5_118596025_118596197	0.14	Gm43788	predicted gene 43788	6605	0.16
chr2_104002844_104003003	0.14	Fbxo3	F-box protein 3	24798	0.1
chr4_135989135_135989286	0.14	Pithd1	PITH (C-terminal proteasome-interacting domain of thioredoxin-like) domain containing 1	1946	0.16
chr8_11636365_11636526	0.14	Ankrd10	ankyrin repeat domain 10	688	0.29
chr7_139364090_139364263	0.14	Inpp5a	inositol polyphosphate-5-phosphatase A	24933	0.19
chr15_102721608_102721977	0.14	Calcoco1	calcium binding and coiled coil domain 1	339	0.84
chr11_7196610_7196788	0.14	Igfbp1	insulin-like growth factor binding protein 1	1083	0.48
chr11_95687340_95687492	0.14	Gm9796	predicted gene 9796	11727	0.12
chr18_32136413_32136564	0.14	Proc	protein C	742	0.51
chr1_164307490_164307653	0.14	Blzf1	basic leucine zipper nuclear factor 1	82	0.52
chr1_69106645_69106814	0.14	Gm16076	predicted gene 16076	11	0.96
chr10_128298417_128298592	0.14	Il23a	interleukin 23, alpha subunit p19	248	0.74
chr7_27478150_27478347	0.14	Sertad3	SERTA domain containing 3	4480	0.1
chr13_83064851_83065002	0.14	2310067P03Rik	RIKEN cDNA 2310067P03 gene	531	0.88
chr6_73222805_73223119	0.14	Gm40377	predicted gene, 40377	88	0.95
chr1_190847941_190848107	0.14	Rps6kc1	ribosomal protein S6 kinase polypeptide 1	3440	0.28
chr11_121500753_121500917	0.14	Tbcd	tubulin-specific chaperone d	799	0.61
chr2_160210649_160210800	0.13	Gm826	predicted gene 826	102892	0.07
chr16_30255365_30255526	0.13	Gm49645	predicted gene, 49645	293	0.87
chr17_32364458_32364626	0.13	Wiz	widely-interspaced zinc finger motifs	79	0.95
chr19_6243342_6243519	0.13	Atg2a	autophagy related 2A	1762	0.16
chr17_79715662_79715994	0.13	Cyp1b1	cytochrome P450, family 1, subfamily b, polypeptide 1	767	0.62
chr14_31929383_31929549	0.13	D830044D21Rik	RIKEN cDNA D830044D21 gene	22938	0.17
chr8_126685352_126685531	0.13	Gm45805	predicted gene 45805	72893	0.1
chr9_80026313_80026485	0.13	Filip1	filamin A interacting protein 1	13548	0.14
chr1_166032024_166032183	0.13	Gm7626	predicted gene 7626	11588	0.15
chr9_64053601_64053804	0.13	Gm25606	predicted gene, 25606	5206	0.14
chr10_115479053_115479225	0.13	Lgr5	leucine rich repeat containing G protein coupled receptor 5	16060	0.19
chr15_85709424_85709582	0.13	Mirlet7b	microRNA let7b	2184	0.21
chr9_46053003_46053558	0.13	Sik3	SIK family kinase 3	40280	0.11
chr11_75689615_75689766	0.13	Crk	v-crk avian sarcoma virus CT10 oncogene homolog	10148	0.13
chr4_44997094_44997250	0.13	1700055D18Rik	RIKEN cDNA 1700055D18 gene	14515	0.1
chr4_145037079_145037530	0.13	Vps13d	vacuolar protein sorting 13D	13730	0.24
chr4_139373277_139373435	0.13	Ubr4	ubiquitin protein ligase E3 component n-recognin 4	7303	0.1
chr6_88292396_88292777	0.13	Gm44265	predicted gene, 44265	61020	0.08
chr4_104973013_104973233	0.13	Gm12721	predicted gene 12721	2994	0.33
chr8_71375544_71375702	0.13	Nr2f6	nuclear receptor subfamily 2, group F, member 6	167	0.89
chr10_69288238_69288393	0.13	Rhobtb1	Rho-related BTB domain containing 1	8857	0.18
chr4_136248818_136248972	0.12	Tcea3	transcription elongation factor A (SII), 3	922	0.5
chr6_108254587_108254738	0.12	Itpr1	inositol 1,4,5-trisphosphate receptor 1	1704	0.47
chrX_100447303_100447475	0.12	Awat2	acyl-CoA wax alcohol acyltransferase 2	4672	0.17
chr1_72226394_72226550	0.12	Gm25360	predicted gene, 25360	232	0.89
chr9_62421178_62421341	0.12	Coro2b	coronin, actin binding protein, 2B	6742	0.24
chr11_86921243_86921467	0.12	Ypel2	yippee like 2	50669	0.12
chr8_70221071_70221246	0.12	Armc6	armadillo repeat containing 6	1132	0.32
chr18_38180760_38180944	0.12	Pcdh1	protocadherin 1	22311	0.12
chr8_124750214_124750687	0.12	Fam89a	family with sequence similarity 89, member A	1382	0.3
chr8_93043146_93043627	0.12	Ces1a	carboxylesterase 1A	2283	0.25
chr7_25390104_25390268	0.12	Lipe	lipase, hormone sensitive	80	0.94
chr4_141131590_141132080	0.12	Szrd1	SUZ RNA binding domain containing 1	7892	0.11
chr1_161247888_161248058	0.12	Prdx6	peroxiredoxin 6	2581	0.25
chr10_77118262_77118451	0.12	Col18a1	collagen, type XVIII, alpha 1	4410	0.2
chr18_20188219_20188403	0.12	Dsg1c	desmoglein 1 gamma	59029	0.12
chr5_139499620_139499800	0.12	Zfand2a	zinc finger, AN1-type domain 2A	15161	0.13
chr9_40805180_40805541	0.12	Snord14e	small nucleolar RNA, C/D box 14E	612	0.38
chr12_30943371_30943530	0.12	Sh3yl1	Sh3 domain YSC-like 1	31263	0.14
chr5_34187720_34187884	0.12	Mxd4	Max dimerization protein 4	82	0.94
chr14_29996362_29996748	0.12	Il17rb	interleukin 17 receptor B	1904	0.2
chr8_84743526_84743857	0.12	G430095P16Rik	RIKEN cDNA G430095P16 gene	20684	0.09
chr12_104841328_104841498	0.11	4930408O17Rik	RIKEN cDNA 4930408O17 gene	15958	0.18
chr10_41575979_41576291	0.11	5730435O14Rik	RIKEN cDNA 5730435O14 gene	571	0.67
chr11_119913012_119913281	0.11	Chmp6	charged multivesicular body protein 6	295	0.86
chr10_67025749_67025925	0.11	Gm31763	predicted gene, 31763	2528	0.28
chr3_104360355_104360770	0.11	Gm5546	predicted gene 5546	6051	0.18
chr17_25239677_25239863	0.11	Gnptg	N-acetylglucosamine-1-phosphotransferase, gamma subunit	346	0.47
chr11_50137654_50137855	0.11	Tbc1d9b	TBC1 domain family, member 9B	2327	0.18
chr8_22124586_22124925	0.11	Nek5	NIMA (never in mitosis gene a)-related expressed kinase 5	283	0.87
chr8_84346540_84346704	0.11	Cacna1a	calcium channel, voltage-dependent, P/Q type, alpha 1A subunit	7983	0.14
chr15_100637292_100637581	0.11	Smagp	small cell adhesion glycoprotein	496	0.61
chr8_70775755_70775922	0.11	Pik3r2	phosphoinositide-3-kinase regulatory subunit 2	841	0.26
chr10_84416787_84416966	0.11	Nuak1	NUAK family, SNF1-like kinase, 1	23721	0.15
chr5_122263936_122264091	0.11	Tctn1	tectonic family member 1	402	0.76
chr12_46635586_46635767	0.11	Gm48535	predicted gene, 48535	30033	0.15
chr9_80777245_80777426	0.11	Gm27224	predicted gene 27224	25316	0.22
chr8_126808574_126808734	0.11	A630001O12Rik	RIKEN cDNA A630001O12 gene	30579	0.17
chr18_69502311_69502466	0.11	Tcf4	transcription factor 4	1430	0.53
chr19_46975598_46975758	0.11	Nt5c2	5'-nucleotidase, cytosolic II	6110	0.17
chr13_75598831_75599007	0.11	Gm4149	predicted pseudogene 4149	45977	0.1
chr4_62508801_62509208	0.11	Hdhd3	haloacid dehalogenase-like hydrolase domain containing 3	5537	0.12
chr18_38283827_38284012	0.11	Pcdh12	protocadherin 12	438	0.52
chr12_40580026_40580177	0.11	Dock4	dedicator of cytokinesis 4	133765	0.05
chr1_58112957_58113355	0.11	Aox3	aldehyde oxidase 3	18	0.98
chr13_67780014_67780192	0.11	Zfp493	zinc finger protein 493	349	0.76
chr3_121291310_121291524	0.11	Alg14	asparagine-linked glycosylation 14	356	0.84
chr6_99490333_99490484	0.11	Gm22328	predicted gene, 22328	5706	0.22
chr17_14173768_14173919	0.10	Gm34510	predicted gene, 34510	29885	0.13
chr14_66654420_66654619	0.10	Adra1a	adrenergic receptor, alpha 1a	18963	0.22
chr4_135286870_135287040	0.10	Gm12983	predicted gene 12983	3720	0.15
chr5_103738632_103738798	0.10	Aff1	AF4/FMR2 family, member 1	15447	0.19
chr12_102647960_102648119	0.10	Itpk1	inositol 1,3,4-triphosphate 5/6 kinase	7105	0.14
chr15_77924420_77924584	0.10	Txn2	thioredoxin 2	3233	0.19
chr9_74921528_74921682	0.10	Fam214a	family with sequence similarity 214, member A	31279	0.14
chr17_31391456_31391613	0.10	Pde9a	phosphodiesterase 9A	5240	0.16
chr5_114581660_114581827	0.10	Fam222a	family with sequence similarity 222, member A	13726	0.15
chr14_20138027_20138204	0.10	Saysd1	SAYSVFN motif domain containing 1	419	0.81
chr10_24097646_24097797	0.10	Taar8c	trace amine-associated receptor 8C	4191	0.1
chr4_148214912_148215063	0.10	Disp3	dispatched RND transporter family member 3	45764	0.08
chr3_119783480_119783653	0.10	Ptbp2	polypyrimidine tract binding protein 2	125	0.96
chr5_114435733_114435884	0.10	Mmab	methylmalonic aciduria (cobalamin deficiency) cblB type homolog (human)	8184	0.14
chr5_74316665_74316828	0.10	Gm15981	predicted gene 15981	288	0.89
chr8_119445523_119446899	0.10	Necab2	N-terminal EF-hand calcium binding protein 2	508	0.74
chr7_115565335_115565528	0.10	Sox6	SRY (sex determining region Y)-box 6	32465	0.24
chr2_166952238_166952420	0.10	Stau1	staufen double-stranded RNA binding protein 1	1098	0.41
chr1_10212196_10212367	0.10	Arfgef1	ADP-ribosylation factor guanine nucleotide-exchange factor 1(brefeldin A-inhibited)	1932	0.35
chrX_20819269_20819429	0.10	Gm24824	predicted gene, 24824	4465	0.13
chr6_94357642_94357793	0.10	Gm19908	predicted gene, 19908	8183	0.21
chr15_96699087_96699266	0.10	Slc38a2	solute carrier family 38, member 2	485	0.66
chr4_97772221_97772394	0.10	Nfia	nuclear factor I/A	427	0.84
chr15_64152976_64153142	0.10	Asap1	ArfGAP with SH3 domain, ankyrin repeat and PH domain1	29253	0.18
chr8_124275783_124275948	0.10	Galnt2	polypeptide N-acetylgalactosaminyltransferase 2	19238	0.16
chr8_120295587_120295753	0.10	Gse1	genetic suppressor element 1, coiled-coil protein	67214	0.09
chr12_24627702_24627853	0.10	Gm6969	predicted pseudogene 6969	11233	0.15
chr7_100658408_100658565	0.10	Plekhb1	pleckstrin homology domain containing, family B (evectins) member 1	30	0.96
chr17_13699350_13699759	0.09	Gm16046	predicted gene 16046	16038	0.13
chr17_56470625_56470795	0.09	Ptprs	protein tyrosine phosphatase, receptor type, S	3917	0.18
chr11_46579639_46579790	0.09	BC053393	cDNA sequence BC053393	8178	0.13

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of Tfap2e

View svg image
View png image

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.2	GO:0043380	regulation of memory T cell differentiation(GO:0043380)
0.0	0.1	GO:0006363	termination of RNA polymerase I transcription(GO:0006363)
0.0	0.2	GO:0043456	regulation of pentose-phosphate shunt(GO:0043456)
0.0	0.1	GO:0019448	cysteine catabolic process(GO:0009093) L-cysteine catabolic process(GO:0019448) L-cysteine metabolic process(GO:0046439)
0.0	0.1	GO:2000670	positive regulation of dendritic cell apoptotic process(GO:2000670)
0.0	0.1	GO:0002930	trabecular meshwork development(GO:0002930)
0.0	0.1	GO:0051599	response to hydrostatic pressure(GO:0051599)
0.0	0.1	GO:0010571	positive regulation of nuclear cell cycle DNA replication(GO:0010571)
0.0	0.1	GO:0006624	vacuolar protein processing(GO:0006624)
0.0	0.1	GO:0060178	regulation of exocyst localization(GO:0060178)
0.0	0.1	GO:1904491	protein localization to ciliary transition zone(GO:1904491)
0.0	0.1	GO:0015722	canalicular bile acid transport(GO:0015722)
0.0	0.0	GO:1903336	negative regulation of vacuolar transport(GO:1903336)
0.0	0.0	GO:0021847	ventricular zone neuroblast division(GO:0021847)
0.0	0.1	GO:0009115	xanthine catabolic process(GO:0009115)
0.0	0.1	GO:0007023	post-chaperonin tubulin folding pathway(GO:0007023)
0.0	0.1	GO:0030208	dermatan sulfate biosynthetic process(GO:0030208)
0.0	0.1	GO:1901668	regulation of superoxide dismutase activity(GO:1901668)
0.0	0.1	GO:0090230	regulation of centromere complex assembly(GO:0090230)
0.0	0.1	GO:0045079	negative regulation of chemokine biosynthetic process(GO:0045079)
0.0	0.2	GO:0043249	erythrocyte maturation(GO:0043249)
0.0	0.1	GO:1900126	negative regulation of hyaluronan biosynthetic process(GO:1900126)
0.0	0.1	GO:1903142	positive regulation of endothelial cell development(GO:1901552) positive regulation of establishment of endothelial barrier(GO:1903142)
0.0	0.1	GO:0032483	regulation of Rab protein signal transduction(GO:0032483)
0.0	0.1	GO:0016095	polyprenol catabolic process(GO:0016095)
0.0	0.1	GO:1902744	negative regulation of lamellipodium organization(GO:1902744)
0.0	0.0	GO:0086046	membrane depolarization during SA node cell action potential(GO:0086046)
0.0	0.1	GO:0060830	ciliary receptor clustering involved in smoothened signaling pathway(GO:0060830)
0.0	0.0	GO:0035511	oxidative DNA demethylation(GO:0035511)
0.0	0.1	GO:0050955	thermoception(GO:0050955)
0.0	0.1	GO:0050882	voluntary musculoskeletal movement(GO:0050882)
0.0	0.1	GO:0034214	protein hexamerization(GO:0034214)
0.0	0.1	GO:0051601	exocyst localization(GO:0051601)
0.0	0.0	GO:0018171	peptidyl-cysteine oxidation(GO:0018171)
0.0	0.0	GO:0014734	skeletal muscle hypertrophy(GO:0014734)
0.0	0.1	GO:0010727	negative regulation of hydrogen peroxide metabolic process(GO:0010727)
0.0	0.1	GO:2000562	negative regulation of CD4-positive, alpha-beta T cell proliferation(GO:2000562)
0.0	0.1	GO:0052805	histidine catabolic process(GO:0006548) imidazole-containing compound catabolic process(GO:0052805)
0.0	0.0	GO:0055005	ventricular cardiac myofibril assembly(GO:0055005)
0.0	0.0	GO:0038128	ERBB2 signaling pathway(GO:0038128)
0.0	0.1	GO:1904667	negative regulation of ubiquitin protein ligase activity(GO:1904667)
0.0	0.0	GO:0071895	odontoblast differentiation(GO:0071895)
0.0	0.0	GO:0007084	mitotic nuclear envelope reassembly(GO:0007084)
0.0	0.1	GO:0051122	hepoxilin metabolic process(GO:0051121) hepoxilin biosynthetic process(GO:0051122)
0.0	0.2	GO:0034724	DNA replication-independent nucleosome assembly(GO:0006336) DNA replication-independent nucleosome organization(GO:0034724)
0.0	0.1	GO:2000074	regulation of type B pancreatic cell development(GO:2000074)
0.0	0.1	GO:0042118	endothelial cell activation(GO:0042118)
0.0	0.1	GO:0051895	negative regulation of focal adhesion assembly(GO:0051895)
0.0	0.0	GO:0021590	cerebellum maturation(GO:0021590)
0.0	0.1	GO:0008291	acetylcholine metabolic process(GO:0008291) acetate ester metabolic process(GO:1900619)
0.0	0.0	GO:1903660	regulation of complement-dependent cytotoxicity(GO:1903659) negative regulation of complement-dependent cytotoxicity(GO:1903660)
0.0	0.0	GO:0002159	desmosome assembly(GO:0002159)

Gene overrepresentation in cellular component category:

Total log-likelihood	Term	Description
0.1	GO:0005955	calcineurin complex(GO:0005955)
0.2	GO:0036156	inner dynein arm(GO:0036156)
0.1	GO:0098553	integral component of cytoplasmic side of endoplasmic reticulum membrane(GO:0071458) integral component of lumenal side of endoplasmic reticulum membrane(GO:0071556) lumenal side of endoplasmic reticulum membrane(GO:0098553)
0.1	GO:0000815	ESCRT III complex(GO:0000815)
0.0	GO:0034274	Atg12-Atg5-Atg16 complex(GO:0034274)
0.1	GO:0000788	nuclear nucleosome(GO:0000788)
0.1	GO:0000138	Golgi trans cisterna(GO:0000138)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.2	GO:0046538	bisphosphoglycerate mutase activity(GO:0004082) phosphoglycerate mutase activity(GO:0004619) 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity(GO:0046538)
0.0	0.1	GO:0047961	glycine N-acyltransferase activity(GO:0047961)
0.0	0.1	GO:0043398	HLH domain binding(GO:0043398)
0.0	0.1	GO:0042134	rRNA primary transcript binding(GO:0042134)
0.0	0.2	GO:0031995	insulin-like growth factor II binding(GO:0031995)
0.0	0.1	GO:0008379	thioredoxin peroxidase activity(GO:0008379)
0.0	0.2	GO:0019870	potassium channel inhibitor activity(GO:0019870)
0.0	0.1	GO:0004854	xanthine dehydrogenase activity(GO:0004854) oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor(GO:0016726)
0.0	0.1	GO:0031697	beta-1 adrenergic receptor binding(GO:0031697)
0.0	0.1	GO:0003976	UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity(GO:0003976)
0.0	0.1	GO:0008559	xenobiotic-transporting ATPase activity(GO:0008559)
0.0	0.1	GO:0016842	amidine-lyase activity(GO:0016842)
0.0	0.1	GO:0005220	inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.0	0.1	GO:1901702	urate transmembrane transporter activity(GO:0015143) salt transmembrane transporter activity(GO:1901702)
0.0	0.1	GO:0086056	voltage-gated calcium channel activity involved in AV node cell action potential(GO:0086056)
0.0	0.1	GO:0003865	3-oxo-5-alpha-steroid 4-dehydrogenase activity(GO:0003865) cholestenone 5-alpha-reductase activity(GO:0047751)
0.0	0.0	GO:0004938	alpha2-adrenergic receptor activity(GO:0004938)
0.0	0.0	GO:0035514	DNA demethylase activity(GO:0035514)
0.0	0.1	GO:0008486	diphosphoinositol-polyphosphate diphosphatase activity(GO:0008486)
0.0	0.1	GO:0034714	type III transforming growth factor beta receptor binding(GO:0034714)
0.0	0.0	GO:0050692	DBD domain binding(GO:0050692)
0.0	0.0	GO:0015119	hexose phosphate transmembrane transporter activity(GO:0015119) organophosphate:inorganic phosphate antiporter activity(GO:0015315) hexose-phosphate:inorganic phosphate antiporter activity(GO:0015526) glucose 6-phosphate:inorganic phosphate antiporter activity(GO:0061513)
0.0	0.0	GO:0003886	DNA (cytosine-5-)-methyltransferase activity(GO:0003886) DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates(GO:0051718)
0.0	0.0	GO:0019776	Atg8 ligase activity(GO:0019776)
0.0	0.0	GO:0033192	calmodulin-dependent protein phosphatase activity(GO:0033192)
0.0	0.1	GO:0005007	fibroblast growth factor-activated receptor activity(GO:0005007)
0.0	0.0	GO:1904288	BAT3 complex binding(GO:1904288)

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Total log-likelihood	Term	Description
0.1	REACTOME RECYCLING OF BILE ACIDS AND SALTS	Genes involved in Recycling of bile acids and salts
0.2	REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS	Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.1	REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS	Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.0	REACTOME SIGNALING BY FGFR3 MUTANTS	Genes involved in Signaling by FGFR3 mutants