Project

ENCSR904DTN: DNase-seq of mouse liver in constant darkness

Navigation

Downloads

CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for Thrb

Z-value: 1.82

Motif logo

Transcription factors associated with Thrb

Gene Symbol	Gene ID	Gene Info
Thrb Ensembl NCBI MGI UniProt	ENSMUSG00000021779.10	Thrb

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

Gene	Promoter	Distance	Association probability	Pearson corr. coef.	P-value	Plot
Thrb	chr14_17695776_17695955	34969	0.214039	-0.98	8.9e-04	Click!
Thrb	chr14_17681136_17681362	20353	0.265627	-0.95	4.1e-03	Click!
Thrb	chr14_17681830_17681997	21017	0.263428	-0.95	4.2e-03	Click!
Thrb	chr14_17685511_17685778	24748	0.250711	0.94	4.6e-03	Click!
Thrb	chr14_17915471_17915812	47180	0.161904	-0.94	5.0e-03	Click!

Activity of the Thrb motif across conditions

Conditions sorted by the z-value of the Thrb motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr7_126260333_126260533	1.81	Sbk1	SH3-binding kinase 1	11571	0.11
chr14_25377112_25377271	1.48	Gm26660	predicted gene, 26660	1444	0.44
chr19_4436418_4436609	1.40	A930001C03Rik	RIKEN cDNA A930001C03 gene	2490	0.17
chr19_10901185_10901365	1.37	Prpf19	pre-mRNA processing factor 19	993	0.37
chr4_142069494_142069660	1.31	Tmem51os1	Tmem51 opposite strand 1	14395	0.13
chr3_98288408_98289120	1.31	Gm43189	predicted gene 43189	1776	0.28
chr16_31994081_31994256	1.29	Hmgb1-ps6	high mobility group box 1, pseudogene 6	2300	0.13
chr19_5763306_5763457	1.29	Scyl1	SCY1-like 1 (S. cerevisiae)	1605	0.16
chr10_70099167_70099342	1.28	Ccdc6	coiled-coil domain containing 6	2133	0.41
chr1_86600398_86600549	1.27	Cops7b	COP9 signalosome subunit 7B	3733	0.15
chr12_111514450_111514666	1.26	Gm40578	predicted gene, 40578	13718	0.1
chr4_148215189_148215340	1.25	Disp3	dispatched RND transporter family member 3	45487	0.08
chr6_112939448_112939605	1.22	Srgap3	SLIT-ROBO Rho GTPase activating protein 3	7228	0.15
chr2_36244831_36245001	1.17	Ptgs1	prostaglandin-endoperoxide synthase 1	2441	0.18
chr8_114982881_114983044	1.15	Gm22556	predicted gene, 22556	69951	0.14
chr11_82015046_82015230	1.13	Gm31522	predicted gene, 31522	4829	0.14
chr12_98573684_98573967	1.06	Kcnk10	potassium channel, subfamily K, member 10	887	0.51
chr2_151943059_151943241	1.04	Gm14154	predicted gene 14154	7491	0.14
chr3_83850904_83851066	1.03	Tlr2	toll-like receptor 2	9218	0.2
chr19_23110526_23110678	1.02	2410080I02Rik	RIKEN cDNA 2410080I02 gene	24298	0.14
chr14_45315776_45315957	1.02	Ero1l	ERO1-like (S. cerevisiae)	2706	0.19
chr1_191224850_191225043	1.01	D730003I15Rik	RIKEN cDNA D730003I15 gene	472	0.74
chr17_13425168_13425333	0.99	Rnu6	U6 small nuclear RNA	6889	0.12
chr11_82845122_82845302	0.99	Rffl	ring finger and FYVE like domain containing protein	880	0.45
chr13_56648096_56648259	0.98	Tgfbi	transforming growth factor, beta induced	16964	0.19
chr2_104130173_104130336	0.98	A930018P22Rik	RIKEN cDNA A930018P22 gene	7485	0.14
chr18_24652431_24652590	0.97	Mocos	molybdenum cofactor sulfurase	1181	0.43
chr17_7387699_7387859	0.97	Unc93a2	unc-93 homolog A2	2315	0.22
chr6_121890040_121890777	0.95	Mug1	murinoglobulin 1	4831	0.21
chr5_9056138_9056296	0.95	Gm40264	predicted gene, 40264	21093	0.14
chr5_32141078_32141248	0.92	Fosl2	fos-like antigen 2	4990	0.17
chr10_61929391_61929572	0.91	Gm5750	predicted gene 5750	30143	0.16
chr15_102091806_102092001	0.89	Eif4b	eukaryotic translation initiation factor 4B	2661	0.17
chr3_98245800_98245972	0.87	Gm42821	predicted gene 42821	2713	0.21
chr5_121856848_121857131	0.86	Pheta1	PH domain containing endocytic trafficking adaptor 1	7984	0.11
chr14_26450001_26450182	0.86	Slmap	sarcolemma associated protein	7201	0.16
chr3_10294464_10294624	0.83	Fabp12	fatty acid binding protein 12	6630	0.1
chr3_36475756_36475914	0.82	Anxa5	annexin A5	59	0.49
chr9_22420603_22420765	0.81	9530077C05Rik	RIKEN cDNA 9530077C05 gene	9045	0.11
chr1_24693656_24693810	0.81	Lmbrd1	LMBR1 domain containing 1	14807	0.17
chr7_132578212_132578403	0.81	Oat	ornithine aminotransferase	1909	0.28
chr1_60824712_60825126	0.81	Gm11581	predicted gene 11581	15803	0.12
chr15_99837964_99838156	0.80	Lima1	LIM domain and actin binding 1	17917	0.08
chr11_109347489_109347695	0.78	1700096J18Rik	RIKEN cDNA 1700096J18 gene	753	0.57
chr1_161750733_161750915	0.78	Gm5049	predicted gene 5049	4768	0.17
chr9_57652474_57652625	0.78	Csk	c-src tyrosine kinase	922	0.44
chr11_119056313_119056482	0.77	Cbx8	chromobox 8	15428	0.14
chr3_108046974_108047188	0.77	Gstm4	glutathione S-transferase, mu 4	2187	0.13
chr3_146846305_146846456	0.76	Ttll7	tubulin tyrosine ligase-like family, member 7	5987	0.18
chr8_106619727_106619898	0.75	Cdh1	cadherin 1	15669	0.17
chr15_97029707_97029895	0.74	Slc38a4	solute carrier family 38, member 4	1410	0.55
chr11_62934808_62934982	0.73	Tvp23bos	trans-golgi network vesicle protein 23B, opposite strand	13303	0.13
chr6_70814000_70814168	0.73	Rpia	ribose 5-phosphate isomerase A	21852	0.13
chr9_113738969_113739195	0.73	Clasp2	CLIP associating protein 2	2391	0.3
chr18_61374503_61374706	0.72	Gm25301	predicted gene, 25301	23209	0.12
chr12_24630346_24630510	0.70	Gm6969	predicted pseudogene 6969	8582	0.16
chr14_17916764_17916922	0.70	Thrb	thyroid hormone receptor beta	45978	0.16
chr6_134043668_134043819	0.70	Etv6	ets variant 6	7774	0.2
chr15_99820031_99820226	0.70	Lima1	LIM domain and actin binding 1	15	0.93
chr13_34739256_34739451	0.69	Fam50b	family with sequence similarity 50, member B	259	0.88
chr8_36202101_36202262	0.69	Gm35520	predicted gene, 35520	13809	0.15
chr6_128498166_128498338	0.68	Pzp	PZP, alpha-2-macroglobulin like	3029	0.13
chr15_75314541_75314705	0.68	Gm3454	predicted gene 3454	341	0.79
chr4_106988955_106989270	0.68	Ssbp3	single-stranded DNA binding protein 3	22686	0.15
chr12_85473320_85473671	0.67	Fos	FBJ osteosarcoma oncogene	395	0.83
chr9_70234563_70234714	0.67	Myo1e	myosin IE	27270	0.19
chr8_70657841_70658013	0.67	Pgpep1	pyroglutamyl-peptidase I	489	0.61
chr9_118958897_118959171	0.67	Ctdspl	CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like	29167	0.13
chr11_60935743_60935912	0.66	Map2k3	mitogen-activated protein kinase kinase 3	3761	0.16
chr14_63479379_63479556	0.66	Gm47074	predicted gene, 47074	4091	0.16
chr11_71012867_71013036	0.66	Derl2	Der1-like domain family, member 2	6261	0.09
chr14_18678485_18678659	0.66	Ube2e2	ubiquitin-conjugating enzyme E2E 2	13422	0.25
chr4_133804499_133804683	0.65	Gm25270	predicted gene, 25270	6872	0.14
chr7_81189147_81189298	0.65	Gm44968	predicted gene 44968	15788	0.13
chr12_77216600_77216773	0.65	Fut8	fucosyltransferase 8	21439	0.19
chr15_31545253_31545412	0.65	Marchf6	membrane associated ring-CH-type finger 6	14279	0.12
chr9_107593234_107593397	0.64	Ifrd2	interferon-related developmental regulator 2	688	0.28
chr1_131957507_131957689	0.64	Gm29103	predicted gene 29103	5356	0.12
chr7_19744671_19744853	0.64	Nectin2	nectin cell adhesion molecule 2	4771	0.08
chr7_38197786_38197937	0.63	D530033B14Rik	RIKEN cDNA D530033B14 gene	1404	0.32
chr5_24956925_24957102	0.63	1500035N22Rik	RIKEN cDNA 1500035N22 gene	28829	0.14
chr15_99911968_99912127	0.62	Gm20564	predicted gene, 20564	3853	0.1
chr11_75596908_75597126	0.62	4931413K12Rik	RIKEN cDNA 4931413K12 gene	2246	0.16
chr12_98860402_98860781	0.61	A930040O22Rik	RIKEN cDNA A930040O22 gene	28778	0.12
chr6_122161223_122161580	0.61	Mug-ps1	murinoglobulin, pseudogene 1	14614	0.16
chr1_186703631_186703811	0.61	Tgfb2	transforming growth factor, beta 2	612	0.62
chr15_85808535_85808715	0.61	Cdpf1	cysteine rich, DPF motif domain containing 1	2465	0.2
chr8_103180795_103180954	0.60	Gm45391	predicted gene 45391	35928	0.21
chr19_58439431_58439649	0.60	Gfra1	glial cell line derived neurotrophic factor family receptor alpha 1	14926	0.22
chr13_43232609_43232789	0.60	Tbc1d7	TBC1 domain family, member 7	61198	0.1
chr12_108856815_108857551	0.60	Gm22079	predicted gene, 22079	5486	0.1
chr4_150065927_150066095	0.59	Mir34a	microRNA 34a	2443	0.16
chr16_47171920_47172088	0.59	Gm18169	predicted gene, 18169	40366	0.21
chr13_41239510_41239683	0.59	Gm32063	predicted gene, 32063	3251	0.15
chr2_34983172_34983323	0.59	Hc	hemolytic complement	10089	0.12
chr6_128483626_128483790	0.58	Pzp	PZP, alpha-2-macroglobulin like	4147	0.1
chr8_126636622_126636807	0.58	Irf2bp2	interferon regulatory factor 2 binding protein 2	42728	0.16
chr10_80973010_80973161	0.57	Gm3828	predicted gene 3828	18375	0.08
chr16_4886806_4886964	0.57	Mgrn1	mahogunin, ring finger 1	499	0.69
chr12_12999123_12999274	0.57	Gm35208	predicted gene, 35208	11881	0.16
chr18_36738903_36739066	0.57	Tmco6	transmembrane and coiled-coil domains 6	3817	0.09
chr7_79358682_79358833	0.56	Rlbp1	retinaldehyde binding protein 1	18946	0.13
chr19_38125391_38125548	0.56	Rbp4	retinol binding protein 4, plasma	188	0.93
chr15_66932473_66932630	0.55	Ndrg1	N-myc downstream regulated gene 1	1918	0.28
chr11_49996483_49996658	0.55	Rnf130	ring finger protein 130	28776	0.14
chr10_120752084_120752244	0.55	Gm10743	predicted gene 10743	3831	0.15
chr13_98684591_98684906	0.55	Tmem171	transmembrane protein 171	10020	0.14
chr6_88913100_88913275	0.54	Tpra1	transmembrane protein, adipocyte asscociated 1	2588	0.17
chr13_69582483_69582651	0.54	Srd5a1	steroid 5 alpha-reductase 1	12262	0.12
chr15_90992378_90992671	0.54	Kif21a	kinesin family member 21A	26122	0.16
chr2_6595830_6596024	0.53	Celf2	CUGBP, Elav-like family member 2	3127	0.35
chr3_101835406_101835600	0.53	Mab21l3	mab-21-like 3	720	0.72
chr19_36692056_36692224	0.52	Hectd2os	Hectd2, opposite strand	2661	0.32
chr5_139612620_139612791	0.52	Uncx	UNC homeobox	68807	0.08
chr13_52153674_52153844	0.52	Gm48199	predicted gene, 48199	26652	0.19
chr7_99641322_99641487	0.52	Gm25409	predicted gene, 25409	12414	0.09
chr8_103538740_103538926	0.52	Gm45277	predicted gene 45277	24790	0.23
chr9_110781917_110782081	0.51	Myl3	myosin, light polypeptide 3	13564	0.1
chr8_12719084_12719404	0.51	Gm15348	predicted gene 15348	117	0.96
chr10_77118451_77118858	0.51	Col18a1	collagen, type XVIII, alpha 1	4708	0.2
chr18_75307577_75307805	0.51	2010010A06Rik	RIKEN cDNA 2010010A06 gene	10362	0.22
chr2_169694792_169694990	0.51	Tshz2	teashirt zinc finger family member 2	61215	0.13
chr2_26600848_26601015	0.51	Agpat2	1-acylglycerol-3-phosphate O-acyltransferase 2 (lysophosphatidic acid acyltransferase, beta)	2785	0.12
chr1_71705120_71705280	0.51	Gm5829	predicted gene 5829	4855	0.2
chr11_24789291_24789442	0.50	Gm10466	predicted gene 10466	58644	0.14
chr2_168005469_168005791	0.50	Gm14236	predicted gene 14236	4899	0.17
chr2_162986609_162986768	0.50	Sgk2	serum/glucocorticoid regulated kinase 2	642	0.6
chr10_115809219_115809409	0.50	Tspan8	tetraspanin 8	7518	0.27
chr4_152177650_152177825	0.50	Acot7	acyl-CoA thioesterase 7	397	0.77
chr9_54560284_54560443	0.50	Cib2	calcium and integrin binding family member 2	145	0.95
chr1_191154426_191154595	0.50	Fam71a	family with sequence similarity 71, member A	10307	0.13
chr17_28290145_28290326	0.50	Ppard	peroxisome proliferator activator receptor delta	3011	0.15
chr10_80928616_80928783	0.50	Gadd45b	growth arrest and DNA-damage-inducible 45 beta	1374	0.25
chr6_86395136_86395301	0.49	Pcyox1	prenylcysteine oxidase 1	1408	0.24
chr13_73723026_73723388	0.48	Slc12a7	solute carrier family 12, member 7	9887	0.15
chr4_34966679_34966979	0.48	Gm12364	predicted gene 12364	4609	0.19
chr16_13240471_13240636	0.48	Mrtfb	myocardin related transcription factor B	15928	0.25
chr2_118554450_118554815	0.48	Bmf	BCL2 modifying factor	4945	0.18
chr11_58801906_58802080	0.47	Fam183b	family with sequence similarity 183, member B	33	0.94
chr1_151496001_151496317	0.47	Gm36527	predicted gene, 36527	3426	0.15
chr6_39286782_39286965	0.47	Gm26008	predicted gene, 26008	20931	0.15
chr13_5832208_5832483	0.46	Gm26043	predicted gene, 26043	10487	0.17
chr6_71204222_71204852	0.46	Fabp1	fatty acid binding protein 1, liver	4710	0.14
chr16_95432244_95432403	0.46	Erg	ETS transcription factor	26922	0.22
chr14_54476038_54476201	0.46	Rem2	rad and gem related GTP binding protein 2	19	0.95
chr17_13662964_13663132	0.46	2700054A10Rik	RIKEN cDNA 2700054A10 gene	5843	0.16
chr8_116184614_116184784	0.46	4930422C21Rik	RIKEN cDNA 4930422C21 gene	2670	0.42
chr4_133028994_133029156	0.46	Ahdc1	AT hook, DNA binding motif, containing 1	10418	0.18
chr1_71648273_71648424	0.46	Apol7d	apolipoprotein L 7d	4489	0.21
chr10_117082015_117082177	0.46	Cct2	chaperonin containing Tcp1, subunit 2 (beta)	18282	0.13
chr7_115825357_115825510	0.45	Sox6	SRY (sex determining region Y)-box 6	723	0.79
chr10_115780280_115780436	0.45	Tspan8	tetraspanin 8	36474	0.2
chr3_104670184_104670346	0.45	Gm29560	predicted gene 29560	255	0.84
chr8_47991010_47991194	0.45	Wwc2	WW, C2 and coiled-coil domain containing 2	178	0.95
chr10_98915744_98915895	0.45	Atp2b1	ATPase, Ca++ transporting, plasma membrane 1	347	0.92
chr12_111956283_111956452	0.44	Gm36757	predicted gene, 36757	5850	0.11
chr18_47219464_47219645	0.44	Sema6a	sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A	61641	0.09
chr2_164563319_164563487	0.44	Wfdc2	WAP four-disulfide core domain 2	384	0.69
chr11_109485510_109486095	0.44	Arsg	arylsulfatase G	196	0.91
chr12_28579239_28579390	0.44	Allc	allantoicase	3201	0.2
chr6_122249737_122249965	0.44	Mug-ps1	murinoglobulin, pseudogene 1	20791	0.13
chr8_89364350_89364531	0.44	Gm5356	predicted pseudogene 5356	176880	0.03
chr18_61909022_61909179	0.43	Ablim3	actin binding LIM protein family, member 3	2723	0.27
chr19_32476509_32476692	0.43	Minpp1	multiple inositol polyphosphate histidine phosphatase 1	9169	0.14
chr1_57989000_57989391	0.43	Sgo2a	shugoshin 2A	6776	0.19
chr2_77113165_77113335	0.42	Gm44360	predicted gene, 44360	38898	0.16
chr15_11394606_11394765	0.42	Tars	threonyl-tRNA synthetase	2415	0.37
chr16_76349002_76349359	0.42	Nrip1	nuclear receptor interacting protein 1	23857	0.18
chr3_117905348_117905499	0.41	Gm4321	predicted gene 4321	16409	0.2
chr2_21211497_21211673	0.41	Thnsl1	threonine synthase-like 1 (bacterial)	5798	0.17
chr4_148651109_148651502	0.41	Gm572	predicted gene 572	7988	0.14
chr6_99145207_99145385	0.41	Foxp1	forkhead box P1	17722	0.26
chr7_126475278_126475550	0.41	Sh2b1	SH2B adaptor protein 1	10	0.95
chr6_81944489_81944663	0.40	Gcfc2	GC-rich sequence DNA binding factor 2	1927	0.23
chr1_127459100_127459460	0.40	Tmem163	transmembrane protein 163	41064	0.15
chr11_63046542_63046708	0.40	Tekt3	tektin 3	15029	0.18
chr18_60738849_60739016	0.40	Ndst1	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1	5782	0.16
chr15_25714163_25714331	0.40	Myo10	myosin X	376	0.88
chr13_37857409_37857582	0.40	Rreb1	ras responsive element binding protein 1	439	0.85
chr1_174959965_174960140	0.39	Grem2	gremlin 2, DAN family BMP antagonist	38233	0.21
chr9_118101918_118102083	0.39	Azi2	5-azacytidine induced gene 2	42944	0.13
chr3_104638838_104638989	0.38	Slc16a1	solute carrier family 16 (monocarboxylic acid transporters), member 1	245	0.84
chr2_32248839_32249007	0.38	Pomt1	protein-O-mannosyltransferase 1	260	0.81
chr6_72227116_72227283	0.38	Atoh8	atonal bHLH transcription factor 8	7338	0.17
chr11_62487069_62487231	0.38	Gm12278	predicted gene 12278	4353	0.13
chr8_116367840_116368103	0.38	1700018P08Rik	RIKEN cDNA 1700018P08 gene	10910	0.29
chr8_70104635_70104800	0.38	Mir7066	microRNA 7066	2131	0.15
chr15_34527692_34527846	0.37	Pop1	processing of precursor 1, ribonuclease P/MRP family, (S. cerevisiae)	1624	0.25
chr5_74874877_74875112	0.37	Gm17906	predicted gene, 17906	8341	0.22
chr1_165629214_165629365	0.37	Mpzl1	myelin protein zero-like 1	4797	0.13
chr14_70330142_70330488	0.37	Slc39a14	solute carrier family 39 (zinc transporter), member 14	1203	0.35
chr17_46016022_46016192	0.37	Vegfa	vascular endothelial growth factor A	5265	0.19
chr1_73987938_73988111	0.37	Tns1	tensin 1	961	0.63
chr1_52499794_52500020	0.37	Nab1	Ngfi-A binding protein 1	393	0.8
chr6_116635450_116635635	0.37	Gm44154	predicted gene, 44154	5320	0.11
chr5_115569868_115570025	0.37	Gcn1	GCN1 activator of EIF2AK4	4643	0.11
chr9_83527787_83527959	0.37	Sh3bgrl2	SH3 domain binding glutamic acid-rich protein like 2	20454	0.14
chr12_102297681_102297848	0.37	Rin3	Ras and Rab interactor 3	14123	0.21
chr13_64362005_64362163	0.36	Gm49230	predicted gene, 49230	347	0.71
chr10_75058843_75058998	0.36	Bcr	BCR activator of RhoGEF and GTPase	1672	0.33

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of Thrb

View svg image
View png image

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	0.5	GO:0034633	retinol transport(GO:0034633) isoprenoid transport(GO:0046864) terpenoid transport(GO:0046865)
0.2	0.5	GO:2001271	negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:2001271)
0.1	0.4	GO:0036112	medium-chain fatty-acyl-CoA metabolic process(GO:0036112)
0.1	0.4	GO:0051891	positive regulation of cardioblast differentiation(GO:0051891)
0.1	0.5	GO:1903689	regulation of wound healing, spreading of epidermal cells(GO:1903689)
0.1	0.4	GO:2000741	positive regulation of mesenchymal stem cell differentiation(GO:2000741)
0.1	0.3	GO:0075136	response to defenses of other organism involved in symbiotic interaction(GO:0052173) response to host defenses(GO:0052200) response to host(GO:0075136)
0.1	0.4	GO:0035331	negative regulation of hippo signaling(GO:0035331)
0.1	0.2	GO:1902809	regulation of skeletal muscle fiber differentiation(GO:1902809)
0.1	0.3	GO:0006057	cell wall mannoprotein biosynthetic process(GO:0000032) mannoprotein metabolic process(GO:0006056) mannoprotein biosynthetic process(GO:0006057) cell wall glycoprotein biosynthetic process(GO:0031506) cell wall biogenesis(GO:0042546) cell wall macromolecule biosynthetic process(GO:0044038) chain elongation of O-linked mannose residue(GO:0044845) cellular component macromolecule biosynthetic process(GO:0070589)
0.1	0.2	GO:0009233	menaquinone metabolic process(GO:0009233)
0.1	0.2	GO:0019371	cyclooxygenase pathway(GO:0019371)
0.1	0.4	GO:0051189	Mo-molybdopterin cofactor biosynthetic process(GO:0006777) Mo-molybdopterin cofactor metabolic process(GO:0019720) molybdopterin cofactor biosynthetic process(GO:0032324) molybdopterin cofactor metabolic process(GO:0043545) prosthetic group metabolic process(GO:0051189)
0.1	0.2	GO:0016095	polyprenol catabolic process(GO:0016095)
0.1	0.5	GO:0071318	cellular response to ATP(GO:0071318)
0.1	0.3	GO:0042997	negative regulation of Golgi to plasma membrane protein transport(GO:0042997)
0.1	0.1	GO:0002434	immune complex clearance(GO:0002434)
0.1	0.4	GO:1901317	regulation of sperm motility(GO:1901317)
0.1	0.2	GO:2000409	positive regulation of T cell extravasation(GO:2000409)
0.1	0.4	GO:0043951	negative regulation of cAMP-mediated signaling(GO:0043951)
0.1	0.5	GO:0000244	spliceosomal tri-snRNP complex assembly(GO:0000244)
0.1	0.2	GO:0007296	vitellogenesis(GO:0007296)
0.1	0.2	GO:0034214	protein hexamerization(GO:0034214)
0.1	0.4	GO:1901660	calcium ion export(GO:1901660)
0.1	0.2	GO:0032439	endosome localization(GO:0032439)
0.0	0.2	GO:0006566	threonine metabolic process(GO:0006566)
0.0	0.1	GO:0006015	5-phosphoribose 1-diphosphate biosynthetic process(GO:0006015) 5-phosphoribose 1-diphosphate metabolic process(GO:0046391)
0.0	0.2	GO:0051541	elastin metabolic process(GO:0051541)
0.0	0.1	GO:0006435	threonyl-tRNA aminoacylation(GO:0006435)
0.0	0.1	GO:2000645	negative regulation of receptor catabolic process(GO:2000645)
0.0	0.1	GO:0007161	calcium-independent cell-matrix adhesion(GO:0007161)
0.0	0.2	GO:0052428	negative regulation by host of symbiont molecular function(GO:0052405) modification by host of symbiont molecular function(GO:0052428)
0.0	0.1	GO:0015744	succinate transport(GO:0015744)
0.0	0.3	GO:0006104	succinyl-CoA metabolic process(GO:0006104)
0.0	0.1	GO:0001880	Mullerian duct regression(GO:0001880)
0.0	0.1	GO:0030327	prenylated protein catabolic process(GO:0030327)
0.0	0.5	GO:0035873	lactate transport(GO:0015727) lactate transmembrane transport(GO:0035873) plasma membrane lactate transport(GO:0035879)
0.0	0.1	GO:1902564	negative regulation of neutrophil activation(GO:1902564)
0.0	0.2	GO:0034773	histone H4-K20 trimethylation(GO:0034773)
0.0	0.1	GO:0001757	somite specification(GO:0001757)
0.0	0.6	GO:0030322	stabilization of membrane potential(GO:0030322)
0.0	0.2	GO:0003199	endocardial cushion to mesenchymal transition involved in heart valve formation(GO:0003199)
0.0	0.1	GO:0018894	dibenzo-p-dioxin metabolic process(GO:0018894)
0.0	0.3	GO:0030948	negative regulation of vascular endothelial growth factor receptor signaling pathway(GO:0030948)
0.0	0.0	GO:0003330	regulation of extracellular matrix constituent secretion(GO:0003330) positive regulation of extracellular matrix constituent secretion(GO:0003331)
0.0	0.2	GO:0032020	ISG15-protein conjugation(GO:0032020)
0.0	0.1	GO:0060300	regulation of cytokine activity(GO:0060300)
0.0	0.1	GO:1990036	calcium ion import into sarcoplasmic reticulum(GO:1990036)
0.0	0.5	GO:1902895	positive regulation of pri-miRNA transcription from RNA polymerase II promoter(GO:1902895)
0.0	0.2	GO:0034154	toll-like receptor 7 signaling pathway(GO:0034154)
0.0	0.1	GO:0018916	nitrobenzene metabolic process(GO:0018916)
0.0	0.2	GO:0060059	embryonic retina morphogenesis in camera-type eye(GO:0060059)
0.0	0.2	GO:0046654	tetrahydrofolate biosynthetic process(GO:0046654)
0.0	0.1	GO:0060066	oviduct development(GO:0060066)
0.0	0.0	GO:0072361	regulation of glycolytic process by regulation of transcription from RNA polymerase II promoter(GO:0072361)
0.0	0.2	GO:0048702	embryonic neurocranium morphogenesis(GO:0048702)
0.0	0.2	GO:0090232	positive regulation of spindle checkpoint(GO:0090232)
0.0	0.2	GO:0006620	posttranslational protein targeting to membrane(GO:0006620)
0.0	0.1	GO:1903984	positive regulation of TRAIL-activated apoptotic signaling pathway(GO:1903984)
0.0	0.2	GO:0072015	glomerular visceral epithelial cell development(GO:0072015) glomerular epithelial cell development(GO:0072310)
0.0	0.2	GO:1902894	negative regulation of pri-miRNA transcription from RNA polymerase II promoter(GO:1902894)
0.0	0.1	GO:1902109	negative regulation of mitochondrial membrane permeability involved in apoptotic process(GO:1902109)
0.0	0.1	GO:0033578	protein glycosylation in Golgi(GO:0033578)
0.0	0.1	GO:0090611	ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway(GO:0090611)
0.0	0.1	GO:0043578	nuclear matrix organization(GO:0043578) nuclear matrix anchoring at nuclear membrane(GO:0090292)
0.0	0.1	GO:0030174	regulation of DNA-dependent DNA replication initiation(GO:0030174)
0.0	0.1	GO:0022417	protein maturation by protein folding(GO:0022417)
0.0	0.1	GO:0061054	dermatome development(GO:0061054) regulation of dermatome development(GO:0061183)
0.0	0.1	GO:0000707	meiotic DNA recombinase assembly(GO:0000707)
0.0	0.1	GO:0015772	disaccharide transport(GO:0015766) sucrose transport(GO:0015770) oligosaccharide transport(GO:0015772)
0.0	0.1	GO:0006548	histidine catabolic process(GO:0006548) imidazole-containing compound catabolic process(GO:0052805)
0.0	0.3	GO:0001731	formation of translation preinitiation complex(GO:0001731)
0.0	0.1	GO:0006868	glutamine transport(GO:0006868)
0.0	0.0	GO:0043634	polyadenylation-dependent ncRNA catabolic process(GO:0043634) nuclear ncRNA surveillance(GO:0071029) nuclear polyadenylation-dependent rRNA catabolic process(GO:0071035) nuclear polyadenylation-dependent ncRNA catabolic process(GO:0071046)
0.0	0.1	GO:0008050	female courtship behavior(GO:0008050)
0.0	0.1	GO:0070562	regulation of vitamin D receptor signaling pathway(GO:0070562)
0.0	0.1	GO:0051919	positive regulation of fibrinolysis(GO:0051919)
0.0	0.1	GO:0050882	voluntary musculoskeletal movement(GO:0050882)
0.0	0.0	GO:0090271	positive regulation of fibroblast growth factor production(GO:0090271)
0.0	0.1	GO:0048014	Tie signaling pathway(GO:0048014)
0.0	0.1	GO:0048388	endosomal lumen acidification(GO:0048388)
0.0	0.0	GO:1904339	negative regulation of dopaminergic neuron differentiation(GO:1904339)
0.0	0.2	GO:0015670	carbon dioxide transport(GO:0015670)
0.0	0.1	GO:0070889	platelet alpha granule organization(GO:0070889)
0.0	0.2	GO:0071578	zinc II ion transmembrane import(GO:0071578)
0.0	0.1	GO:0089700	protein kinase D signaling(GO:0089700)
0.0	0.1	GO:2000048	negative regulation of cell-cell adhesion mediated by cadherin(GO:2000048)
0.0	0.1	GO:0042908	xenobiotic transport(GO:0042908)
0.0	0.0	GO:2001016	positive regulation of skeletal muscle cell differentiation(GO:2001016)
0.0	0.2	GO:0000185	activation of MAPKKK activity(GO:0000185)
0.0	0.1	GO:2000255	negative regulation of male germ cell proliferation(GO:2000255)
0.0	0.8	GO:0030835	negative regulation of actin filament depolymerization(GO:0030835)
0.0	0.1	GO:0060897	neural plate regionalization(GO:0060897)
0.0	0.1	GO:0080154	regulation of fertilization(GO:0080154)
0.0	0.1	GO:0051791	medium-chain fatty acid metabolic process(GO:0051791)
0.0	0.1	GO:0009080	alanine catabolic process(GO:0006524) pyruvate family amino acid catabolic process(GO:0009080)
0.0	0.1	GO:0048696	regulation of collateral sprouting in absence of injury(GO:0048696)
0.0	0.1	GO:0033387	putrescine biosynthetic process from ornithine(GO:0033387)
0.0	0.2	GO:0046838	phosphorylated carbohydrate dephosphorylation(GO:0046838)
0.0	0.1	GO:2000980	regulation of auditory receptor cell differentiation(GO:0045607) regulation of mechanoreceptor differentiation(GO:0045631) regulation of inner ear receptor cell differentiation(GO:2000980)
0.0	0.1	GO:0010694	positive regulation of alkaline phosphatase activity(GO:0010694)
0.0	0.1	GO:0003419	growth plate cartilage chondrocyte proliferation(GO:0003419)
0.0	0.1	GO:0000727	double-strand break repair via break-induced replication(GO:0000727)
0.0	0.9	GO:0030032	lamellipodium assembly(GO:0030032)
0.0	0.0	GO:0051890	regulation of cardioblast differentiation(GO:0051890)
0.0	0.1	GO:0031086	nuclear-transcribed mRNA catabolic process, deadenylation-independent decay(GO:0031086) deadenylation-independent decapping of nuclear-transcribed mRNA(GO:0031087)
0.0	0.1	GO:0032790	ribosome disassembly(GO:0032790)
0.0	0.2	GO:0010388	cullin deneddylation(GO:0010388)
0.0	0.1	GO:0071673	positive regulation of smooth muscle cell chemotaxis(GO:0071673)
0.0	0.0	GO:0071727	response to triacyl bacterial lipopeptide(GO:0071725) cellular response to triacyl bacterial lipopeptide(GO:0071727)
0.0	0.3	GO:0002710	negative regulation of T cell mediated immunity(GO:0002710)
0.0	0.1	GO:0090403	oxidative stress-induced premature senescence(GO:0090403)
0.0	0.0	GO:0048677	axon extension involved in regeneration(GO:0048677) sprouting of injured axon(GO:0048682)
0.0	0.2	GO:0045898	regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045898)
0.0	0.1	GO:0010760	negative regulation of macrophage chemotaxis(GO:0010760)
0.0	0.1	GO:0061091	regulation of phospholipid translocation(GO:0061091) positive regulation of phospholipid translocation(GO:0061092)
0.0	0.1	GO:0070544	histone H3-K36 demethylation(GO:0070544)
0.0	0.1	GO:0050915	sensory perception of sour taste(GO:0050915)
0.0	0.1	GO:0018095	protein polyglutamylation(GO:0018095)
0.0	0.0	GO:0071316	cellular response to nicotine(GO:0071316)
0.0	0.1	GO:0009052	pentose-phosphate shunt, non-oxidative branch(GO:0009052)
0.0	0.3	GO:0006607	NLS-bearing protein import into nucleus(GO:0006607)
0.0	0.1	GO:0090666	scaRNA localization to Cajal body(GO:0090666)
0.0	0.0	GO:0019064	fusion of virus membrane with host plasma membrane(GO:0019064) membrane fusion involved in viral entry into host cell(GO:0039663) multi-organism membrane fusion(GO:0044800)
0.0	0.1	GO:0060763	mammary duct terminal end bud growth(GO:0060763)
0.0	0.1	GO:1904587	glycoprotein ERAD pathway(GO:0097466) response to glycoprotein(GO:1904587)
0.0	0.0	GO:0065001	specification of axis polarity(GO:0065001)
0.0	0.1	GO:0032464	positive regulation of protein homooligomerization(GO:0032464)
0.0	0.1	GO:1902018	negative regulation of cilium assembly(GO:1902018)
0.0	0.0	GO:0001905	activation of membrane attack complex(GO:0001905) regulation of activation of membrane attack complex(GO:0001969)
0.0	0.0	GO:0045590	negative regulation of regulatory T cell differentiation(GO:0045590)
0.0	0.1	GO:0016078	tRNA catabolic process(GO:0016078)
0.0	0.1	GO:0009115	xanthine catabolic process(GO:0009115)
0.0	0.8	GO:0007566	embryo implantation(GO:0007566)
0.0	0.0	GO:0061038	uterus morphogenesis(GO:0061038)
0.0	0.1	GO:0070236	negative regulation of activation-induced cell death of T cells(GO:0070236)
0.0	0.2	GO:0051132	NK T cell activation(GO:0051132)
0.0	0.0	GO:1904222	regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity(GO:1904217) positive regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity(GO:1904219) regulation of serine C-palmitoyltransferase activity(GO:1904220) positive regulation of serine C-palmitoyltransferase activity(GO:1904222)
0.0	0.0	GO:0035747	natural killer cell chemotaxis(GO:0035747) regulation of natural killer cell chemotaxis(GO:2000501)
0.0	0.1	GO:0031584	activation of phospholipase D activity(GO:0031584)
0.0	0.0	GO:0090296	regulation of mitochondrial DNA replication(GO:0090296)
0.0	0.1	GO:0002606	positive regulation of dendritic cell antigen processing and presentation(GO:0002606)
0.0	0.1	GO:1901525	negative regulation of macromitophagy(GO:1901525)
0.0	0.1	GO:0034626	fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.0	0.0	GO:2000646	positive regulation of receptor catabolic process(GO:2000646)
0.0	0.0	GO:0021773	striatal medium spiny neuron differentiation(GO:0021773)
0.0	0.3	GO:0045663	positive regulation of myoblast differentiation(GO:0045663)
0.0	0.0	GO:0006344	maintenance of chromatin silencing(GO:0006344)
0.0	0.1	GO:1901621	negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning(GO:1901621)
0.0	0.0	GO:0060931	sinoatrial node cell development(GO:0060931)
0.0	0.0	GO:0072386	plus-end-directed vesicle transport along microtubule(GO:0072383) plus-end-directed organelle transport along microtubule(GO:0072386)
0.0	0.0	GO:0000492	small nucleolar ribonucleoprotein complex assembly(GO:0000491) box C/D snoRNP assembly(GO:0000492)
0.0	0.1	GO:0061299	retina vasculature morphogenesis in camera-type eye(GO:0061299)
0.0	0.0	GO:0030091	protein repair(GO:0030091)
0.0	0.3	GO:1902668	negative regulation of axon extension involved in axon guidance(GO:0048843) negative regulation of axon guidance(GO:1902668)
0.0	0.0	GO:0046439	cysteine catabolic process(GO:0009093) L-cysteine catabolic process(GO:0019448) L-cysteine metabolic process(GO:0046439)
0.0	0.0	GO:0048162	preantral ovarian follicle growth(GO:0001546) multi-layer follicle stage(GO:0048162)
0.0	0.0	GO:0001543	ovarian follicle rupture(GO:0001543)
0.0	0.2	GO:0006883	cellular sodium ion homeostasis(GO:0006883)
0.0	0.0	GO:1901187	regulation of ephrin receptor signaling pathway(GO:1901187)
0.0	0.0	GO:0032929	negative regulation of superoxide anion generation(GO:0032929)
0.0	0.0	GO:1904424	regulation of GTP binding(GO:1904424)
0.0	0.0	GO:0035907	dorsal aorta development(GO:0035907) dorsal aorta morphogenesis(GO:0035912)
0.0	0.0	GO:0019087	transformation of host cell by virus(GO:0019087)
0.0	0.0	GO:1901843	positive regulation of high voltage-gated calcium channel activity(GO:1901843)
0.0	0.0	GO:0050427	3'-phosphoadenosine 5'-phosphosulfate metabolic process(GO:0050427)
0.0	0.2	GO:0090200	positive regulation of release of cytochrome c from mitochondria(GO:0090200)
0.0	0.1	GO:0006516	glycoprotein catabolic process(GO:0006516)
0.0	0.0	GO:1901841	regulation of high voltage-gated calcium channel activity(GO:1901841)
0.0	0.1	GO:0051639	actin filament network formation(GO:0051639)
0.0	0.2	GO:0000028	ribosomal small subunit assembly(GO:0000028)
0.0	0.0	GO:0070837	dehydroascorbic acid transport(GO:0070837)
0.0	0.0	GO:0006041	glucosamine metabolic process(GO:0006041)
0.0	0.0	GO:0061368	behavioral response to chemical pain(GO:0061366) behavioral response to formalin induced pain(GO:0061368)
0.0	0.0	GO:0021888	hypothalamus gonadotrophin-releasing hormone neuron differentiation(GO:0021886) hypothalamus gonadotrophin-releasing hormone neuron development(GO:0021888)
0.0	0.0	GO:0070094	positive regulation of glucagon secretion(GO:0070094)
0.0	0.2	GO:0008299	isoprenoid biosynthetic process(GO:0008299)
0.0	0.0	GO:0006222	UMP biosynthetic process(GO:0006222) pyrimidine ribonucleoside monophosphate metabolic process(GO:0009173) pyrimidine ribonucleoside monophosphate biosynthetic process(GO:0009174) UMP metabolic process(GO:0046049)
0.0	0.0	GO:0015755	fructose transport(GO:0015755)
0.0	0.0	GO:0003164	His-Purkinje system development(GO:0003164)
0.0	0.1	GO:0046485	ether lipid metabolic process(GO:0046485)
0.0	0.0	GO:0016561	protein import into peroxisome matrix, translocation(GO:0016561)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.5	GO:0005927	muscle tendon junction(GO:0005927)
0.1	0.3	GO:0031502	dolichyl-phosphate-mannose-protein mannosyltransferase complex(GO:0031502)
0.1	0.2	GO:0030981	cortical microtubule cytoskeleton(GO:0030981)
0.1	0.2	GO:0035355	Toll-like receptor 2-Toll-like receptor 6 protein complex(GO:0035355)
0.1	0.4	GO:0032591	dendritic spine membrane(GO:0032591)
0.0	0.3	GO:0045252	oxoglutarate dehydrogenase complex(GO:0045252)
0.0	0.1	GO:0000172	ribonuclease MRP complex(GO:0000172)
0.0	0.1	GO:0002189	ribose phosphate diphosphokinase complex(GO:0002189)
0.0	0.5	GO:0000974	Prp19 complex(GO:0000974)
0.0	0.2	GO:0000220	vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220)
0.0	0.1	GO:0032299	ribonuclease H2 complex(GO:0032299)
0.0	0.1	GO:0005726	perichromatin fibrils(GO:0005726)
0.0	0.2	GO:0016281	eukaryotic translation initiation factor 4F complex(GO:0016281)
0.0	0.4	GO:0035102	PRC1 complex(GO:0035102)
0.0	0.1	GO:0071141	SMAD protein complex(GO:0071141)
0.0	0.1	GO:0071008	U2-type post-mRNA release spliceosomal complex(GO:0071008)
0.0	0.1	GO:0044299	C-fiber(GO:0044299)
0.0	0.1	GO:0000811	GINS complex(GO:0000811)
0.0	0.1	GO:0044322	endoplasmic reticulum quality control compartment(GO:0044322)
0.0	0.2	GO:0070652	HAUS complex(GO:0070652)
0.0	0.1	GO:0005826	actomyosin contractile ring(GO:0005826)
0.0	0.1	GO:0033063	Rad51B-Rad51C-Rad51D-XRCC2 complex(GO:0033063)
0.0	0.2	GO:0012510	trans-Golgi network transport vesicle membrane(GO:0012510)
0.0	0.1	GO:0036195	muscle cell projection(GO:0036194) muscle cell projection membrane(GO:0036195)
0.0	0.5	GO:0032154	cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.0	0.2	GO:0030126	COPI vesicle coat(GO:0030126)
0.0	0.1	GO:0033588	Elongator holoenzyme complex(GO:0033588)
0.0	0.1	GO:0045179	apical cortex(GO:0045179)
0.0	0.2	GO:0070971	endoplasmic reticulum exit site(GO:0070971)
0.0	0.0	GO:0034679	integrin alpha9-beta1 complex(GO:0034679)
0.0	0.1	GO:0005577	fibrinogen complex(GO:0005577)
0.0	0.2	GO:0031597	cytosolic proteasome complex(GO:0031597)
0.0	0.1	GO:0005832	chaperonin-containing T-complex(GO:0005832)
0.0	0.1	GO:0031262	Ndc80 complex(GO:0031262)
0.0	0.1	GO:1990454	L-type voltage-gated calcium channel complex(GO:1990454)
0.0	0.2	GO:0045334	clathrin-coated endocytic vesicle(GO:0045334)
0.0	0.1	GO:0072357	PTW/PP1 phosphatase complex(GO:0072357)
0.0	0.0	GO:0005971	ribonucleoside-diphosphate reductase complex(GO:0005971)
0.0	0.0	GO:0097443	sorting endosome(GO:0097443)
0.0	0.0	GO:0043511	inhibin complex(GO:0043511)
0.0	0.0	GO:0001739	sex chromatin(GO:0001739)
0.0	0.1	GO:0097197	tetraspanin-enriched microdomain(GO:0097197)
0.0	0.1	GO:0031932	TORC2 complex(GO:0031932)
0.0	0.0	GO:0070761	pre-snoRNP complex(GO:0070761)
0.0	0.1	GO:0034993	microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.0	0.0	GO:0000125	PCAF complex(GO:0000125)
0.0	0.1	GO:0031258	lamellipodium membrane(GO:0031258)
0.0	0.1	GO:0098642	collagen type IV trimer(GO:0005587) network-forming collagen trimer(GO:0098642) collagen network(GO:0098645) basement membrane collagen trimer(GO:0098651)
0.0	0.3	GO:0055038	recycling endosome membrane(GO:0055038)
0.0	0.1	GO:0071986	Ragulator complex(GO:0071986)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:0047751	3-oxo-5-alpha-steroid 4-dehydrogenase activity(GO:0003865) cholestenone 5-alpha-reductase activity(GO:0047751)
0.1	0.4	GO:0030151	molybdenum ion binding(GO:0030151)
0.1	0.4	GO:0018741	alkyl sulfatase activity(GO:0018741) endosulfan hemisulfate sulfatase activity(GO:0034889) endosulfan sulfate hydrolase activity(GO:0034902)
0.1	0.3	GO:0004591	oxoglutarate dehydrogenase (succinyl-transferring) activity(GO:0004591)
0.1	0.2	GO:0043888	4-hydroxybenzoate octaprenyltransferase activity(GO:0008412) protoheme IX farnesyltransferase activity(GO:0008495) (S)-2,3-di-O-geranylgeranylglyceryl phosphate synthase activity(GO:0043888) cadaverine aminopropyltransferase activity(GO:0043918) agmatine aminopropyltransferase activity(GO:0043919) 1,4-dihydroxy-2-naphthoate octaprenyltransferase activity(GO:0046428) trans-pentaprenyltranstransferase activity(GO:0048045) ATP dimethylallyltransferase activity(GO:0052622) ADP dimethylallyltransferase activity(GO:0052623)
0.1	0.3	GO:0034714	type III transforming growth factor beta receptor binding(GO:0034714)
0.1	0.3	GO:0031727	CCR2 chemokine receptor binding(GO:0031727)
0.1	0.7	GO:0005388	calcium-transporting ATPase activity(GO:0005388)
0.1	0.2	GO:0042296	ISG15 transferase activity(GO:0042296)
0.1	0.3	GO:0004169	dolichyl-phosphate-mannose-protein mannosyltransferase activity(GO:0004169)
0.1	0.6	GO:0019841	retinol binding(GO:0019841)
0.0	0.1	GO:0004829	threonine-tRNA ligase activity(GO:0004829)
0.0	0.2	GO:0046912	transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
0.0	0.3	GO:0070891	lipoteichoic acid binding(GO:0070891)
0.0	0.2	GO:0015016	[heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.0	0.5	GO:0015129	lactate transmembrane transporter activity(GO:0015129)
0.0	0.1	GO:0017153	sodium:dicarboxylate symporter activity(GO:0017153)
0.0	0.0	GO:0043546	molybdopterin cofactor binding(GO:0043546)
0.0	0.4	GO:0016920	pyroglutamyl-peptidase activity(GO:0016920)
0.0	0.3	GO:0016151	nickel cation binding(GO:0016151)
0.0	0.2	GO:0097493	structural molecule activity conferring elasticity(GO:0097493)
0.0	0.1	GO:0070137	ubiquitin-like protein-specific endopeptidase activity(GO:0070137) SUMO-specific endopeptidase activity(GO:0070139)
0.0	0.2	GO:0034056	estrogen response element binding(GO:0034056)
0.0	0.1	GO:0000171	ribonuclease MRP activity(GO:0000171)
0.0	0.1	GO:0008603	cAMP-dependent protein kinase regulator activity(GO:0008603)
0.0	0.6	GO:0022841	potassium ion leak channel activity(GO:0022841)
0.0	0.1	GO:0045340	mercury ion binding(GO:0045340)
0.0	0.1	GO:0004749	ribose phosphate diphosphokinase activity(GO:0004749)
0.0	0.3	GO:0048406	nerve growth factor binding(GO:0048406)
0.0	0.2	GO:0003933	GTP cyclohydrolase activity(GO:0003933)
0.0	0.2	GO:0016841	ammonia-lyase activity(GO:0016841)
0.0	0.1	GO:0015093	ferrous iron transmembrane transporter activity(GO:0015093)
0.0	0.1	GO:0030297	transmembrane receptor protein tyrosine kinase activator activity(GO:0030297)
0.0	0.2	GO:0005534	galactose binding(GO:0005534)
0.0	0.1	GO:0031871	proteinase activated receptor binding(GO:0031871)
0.0	0.1	GO:0038191	neuropilin binding(GO:0038191)
0.0	0.5	GO:0030247	pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
0.0	0.1	GO:0004691	cAMP-dependent protein kinase activity(GO:0004691)
0.0	0.1	GO:0015154	sucrose:proton symporter activity(GO:0008506) sucrose transmembrane transporter activity(GO:0008515) disaccharide transmembrane transporter activity(GO:0015154) oligosaccharide transmembrane transporter activity(GO:0015157)
0.0	0.2	GO:0043495	protein anchor(GO:0043495)
0.0	0.2	GO:0000182	rDNA binding(GO:0000182)
0.0	0.1	GO:0004427	inorganic diphosphatase activity(GO:0004427)
0.0	0.6	GO:0070412	R-SMAD binding(GO:0070412)
0.0	0.1	GO:0015182	L-asparagine transmembrane transporter activity(GO:0015182) L-glutamine transmembrane transporter activity(GO:0015186)
0.0	0.1	GO:0070644	vitamin D response element binding(GO:0070644)
0.0	0.1	GO:0005095	GTPase inhibitor activity(GO:0005095)
0.0	0.2	GO:0002162	dystroglycan binding(GO:0002162)
0.0	0.2	GO:0070191	methionine-R-sulfoxide reductase activity(GO:0070191)
0.0	0.1	GO:0004523	RNA-DNA hybrid ribonuclease activity(GO:0004523)
0.0	0.1	GO:0035939	microsatellite binding(GO:0035939)
0.0	0.2	GO:0070181	small ribosomal subunit rRNA binding(GO:0070181)
0.0	0.1	GO:0071535	RING-like zinc finger domain binding(GO:0071535)
0.0	0.1	GO:0016670	oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor(GO:0016670)
0.0	0.0	GO:0005030	neurotrophin receptor activity(GO:0005030)
0.0	0.2	GO:0043024	ribosomal small subunit binding(GO:0043024)
0.0	0.1	GO:0070915	lysophosphatidic acid receptor activity(GO:0070915)
0.0	0.3	GO:0034236	protein kinase A catalytic subunit binding(GO:0034236)
0.0	0.2	GO:0048156	tau protein binding(GO:0048156)
0.0	0.0	GO:0008113	peptide-methionine (S)-S-oxide reductase activity(GO:0008113)
0.0	0.2	GO:0004016	adenylate cyclase activity(GO:0004016)
0.0	0.1	GO:0030957	Tat protein binding(GO:0030957)
0.0	0.1	GO:0036402	proteasome-activating ATPase activity(GO:0036402)
0.0	0.3	GO:0017081	chloride channel regulator activity(GO:0017081)
0.0	0.1	GO:0015379	potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820)
0.0	0.1	GO:0008934	inositol monophosphate 1-phosphatase activity(GO:0008934) inositol monophosphate 3-phosphatase activity(GO:0052832) inositol monophosphate 4-phosphatase activity(GO:0052833) inositol monophosphate phosphatase activity(GO:0052834)
0.0	0.1	GO:0016312	inositol bisphosphate phosphatase activity(GO:0016312)
0.0	0.3	GO:0030351	inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase activity(GO:0030351) inositol-1,4,5,6-tetrakisphosphate 6-phosphatase activity(GO:0030352) inositol pentakisphosphate phosphatase activity(GO:0052827)
0.0	0.1	GO:0051864	histone demethylase activity (H3-K36 specific)(GO:0051864)
0.0	0.3	GO:0030215	semaphorin receptor binding(GO:0030215)
0.0	0.1	GO:0051022	Rho GDP-dissociation inhibitor binding(GO:0051022)
0.0	0.3	GO:0008139	nuclear localization sequence binding(GO:0008139)
0.0	0.1	GO:0030296	protein tyrosine kinase activator activity(GO:0030296)
0.0	0.2	GO:0036312	phosphatidylinositol 3-kinase regulatory subunit binding(GO:0036312)
0.0	0.0	GO:0050692	DBD domain binding(GO:0050692)
0.0	0.1	GO:0031995	insulin-like growth factor II binding(GO:0031995)
0.0	0.0	GO:0046573	lactonohydrolase activity(GO:0046573) acyl-L-homoserine-lactone lactonohydrolase activity(GO:0102007)
0.0	0.1	GO:0070324	thyroid hormone binding(GO:0070324)
0.0	0.1	GO:0042979	ornithine decarboxylase regulator activity(GO:0042979)
0.0	0.1	GO:0042289	MHC class II protein binding(GO:0042289)
0.0	0.2	GO:0008553	hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.0	0.1	GO:0000150	recombinase activity(GO:0000150)
0.0	0.1	GO:0048495	Roundabout binding(GO:0048495)
0.0	0.1	GO:0016401	palmitoyl-CoA oxidase activity(GO:0016401)
0.0	0.0	GO:0003876	AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.0	0.2	GO:0004089	carbonate dehydratase activity(GO:0004089)
0.0	0.1	GO:0004955	prostaglandin receptor activity(GO:0004955)
0.0	0.1	GO:0102336	fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)
0.0	0.1	GO:0015280	ligand-gated sodium channel activity(GO:0015280)
0.0	0.1	GO:0030984	kininogen binding(GO:0030984)
0.0	0.1	GO:0036122	BMP binding(GO:0036122)
0.0	0.0	GO:0070699	type II activin receptor binding(GO:0070699)
0.0	0.0	GO:0034988	Fc-gamma receptor I complex binding(GO:0034988)
0.0	0.1	GO:0047760	butyrate-CoA ligase activity(GO:0047760)
0.0	0.1	GO:0070180	large ribosomal subunit rRNA binding(GO:0070180)
0.0	0.1	GO:0016861	intramolecular oxidoreductase activity, interconverting aldoses and ketoses(GO:0016861)
0.0	0.0	GO:0016728	ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.0	0.0	GO:0043533	inositol 1,3,4,5 tetrakisphosphate binding(GO:0043533)
0.0	0.0	GO:0018595	mono-butyltin dioxygenase activity(GO:0018586) tri-n-butyltin dioxygenase activity(GO:0018588) di-n-butyltin dioxygenase activity(GO:0018589) methylsilanetriol hydroxylase activity(GO:0018590) methyl tertiary butyl ether 3-monooxygenase activity(GO:0018591) 4-nitrocatechol 4-monooxygenase activity(GO:0018592) 4-chlorophenoxyacetate monooxygenase activity(GO:0018593) tert-butanol 2-monooxygenase activity(GO:0018594) alpha-pinene monooxygenase activity(GO:0018595) dimethylsilanediol hydroxylase activity(GO:0018596) ammonia monooxygenase activity(GO:0018597) hydroxymethylsilanetriol oxidase activity(GO:0018598) 2-hydroxyisobutyrate 3-monooxygenase activity(GO:0018599) alpha-pinene dehydrogenase activity(GO:0018600) bisphenol A hydroxylase B activity(GO:0034559) 2,2-bis(4-hydroxyphenyl)-1-propanol hydroxylase activity(GO:0034562) 9-fluorenone-3,4-dioxygenase activity(GO:0034786) anthracene 9,10-dioxygenase activity(GO:0034816) 2-(methylthio)benzothiazole monooxygenase activity(GO:0034857) 2-hydroxybenzothiazole monooxygenase activity(GO:0034858) benzothiazole monooxygenase activity(GO:0034859) 2,6-dihydroxybenzothiazole monooxygenase activity(GO:0034862) pinacolone 5-monooxygenase activity(GO:0034870) thioacetamide S-oxygenase activity(GO:0034873) thioacetamide S-oxide S-oxygenase activity(GO:0034874) endosulfan monooxygenase I activity(GO:0034888) N-nitrodimethylamine hydroxylase activity(GO:0034893) 4-(1-ethyl-1,4-dimethyl-pentyl)phenol monoxygenase activity(GO:0034897) endosulfan ether monooxygenase activity(GO:0034903) pyrene 4,5-monooxygenase activity(GO:0034925) pyrene 1,2-monooxygenase activity(GO:0034927) 1-hydroxypyrene 6,7-monooxygenase activity(GO:0034928) 1-hydroxypyrene 7,8-monooxygenase activity(GO:0034929) phenylboronic acid monooxygenase activity(GO:0034950) spheroidene monooxygenase activity(GO:0043823)
0.0	0.1	GO:0005313	L-glutamate transmembrane transporter activity(GO:0005313) acidic amino acid transmembrane transporter activity(GO:0015172)
0.0	0.2	GO:0001848	complement binding(GO:0001848)
0.0	0.0	GO:0055100	adiponectin binding(GO:0055100)
0.0	0.3	GO:0008483	transaminase activity(GO:0008483)
0.0	0.2	GO:0003785	actin monomer binding(GO:0003785)
0.0	0.0	GO:1990829	C-rich single-stranded DNA binding(GO:1990829)
0.0	0.1	GO:0097027	ubiquitin-protein transferase activator activity(GO:0097027)
0.0	0.1	GO:0061133	endopeptidase activator activity(GO:0061133)
0.0	0.1	GO:0031419	cobalamin binding(GO:0031419)
0.0	0.2	GO:0016290	palmitoyl-CoA hydrolase activity(GO:0016290)
0.0	0.2	GO:0015125	bile acid transmembrane transporter activity(GO:0015125)
0.0	0.1	GO:0051525	NFAT protein binding(GO:0051525)

Gene overrepresentation in curated gene sets: canonical pathways category:

Total log-likelihood	Term	Description
0.5	PID TCR RAS PATHWAY	Ras signaling in the CD4+ TCR pathway
0.5	PID HEDGEHOG 2PATHWAY	Signaling events mediated by the Hedgehog family
0.2	SA FAS SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.
0.2	PID SMAD2 3PATHWAY	Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.2	PID LYMPH ANGIOGENESIS PATHWAY	VEGFR3 signaling in lymphatic endothelium
0.2	PID LPA4 PATHWAY	LPA4-mediated signaling events
0.0	ST TUMOR NECROSIS FACTOR PATHWAY	Tumor Necrosis Factor Pathway.
0.1	PID S1P S1P4 PATHWAY	S1P4 pathway
0.0	PID S1P S1P2 PATHWAY	S1P2 pathway
0.4	PID ECADHERIN STABILIZATION PATHWAY	Stabilization and expansion of the E-cadherin adherens junction
0.3	PID NETRIN PATHWAY	Netrin-mediated signaling events
0.2	PID GMCSF PATHWAY	GMCSF-mediated signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.5	REACTOME THE ACTIVATION OF ARYLSULFATASES	Genes involved in The activation of arylsulfatases
0.1	0.5	REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS	Genes involved in Activation of the AP-1 family of transcription factors
0.1	0.6	REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS	Genes involved in Tandem pore domain potassium channels
0.0	0.2	REACTOME BETA DEFENSINS	Genes involved in Beta defensins
0.0	0.5	REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS	Genes involved in Bile salt and organic anion SLC transporters
0.0	0.1	REACTOME XENOBIOTICS	Genes involved in Xenobiotics
0.0	0.3	REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS	Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.0	0.3	REACTOME ANDROGEN BIOSYNTHESIS	Genes involved in Androgen biosynthesis
0.0	0.3	REACTOME PROLACTIN RECEPTOR SIGNALING	Genes involved in Prolactin receptor signaling
0.0	0.3	REACTOME MTORC1 MEDIATED SIGNALLING	Genes involved in mTORC1-mediated signalling
0.0	0.3	REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION	Genes involved in Amino acid synthesis and interconversion (transamination)
0.0	0.6	REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE	Genes involved in Amino acid transport across the plasma membrane
0.0	0.3	REACTOME SIGNALING BY FGFR1 FUSION MUTANTS	Genes involved in Signaling by FGFR1 fusion mutants
0.0	0.6	REACTOME NETRIN1 SIGNALING	Genes involved in Netrin-1 signaling
0.0	0.2	REACTOME ADENYLATE CYCLASE ACTIVATING PATHWAY	Genes involved in Adenylate cyclase activating pathway
0.0	0.2	REACTOME CD28 DEPENDENT VAV1 PATHWAY	Genes involved in CD28 dependent Vav1 pathway
0.0	0.3	REACTOME CITRIC ACID CYCLE TCA CYCLE	Genes involved in Citric acid cycle (TCA cycle)
0.0	0.3	REACTOME SIGNALING BY NODAL	Genes involved in Signaling by NODAL
0.0	0.3	REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC	Genes involved in Formation of tubulin folding intermediates by CCT/TriC
0.0	0.0	REACTOME DESTABILIZATION OF MRNA BY TRISTETRAPROLIN TTP	Genes involved in Destabilization of mRNA by Tristetraprolin (TTP)
0.0	0.3	REACTOME GLUTATHIONE CONJUGATION	Genes involved in Glutathione conjugation
0.0	0.2	REACTOME TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION	Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
0.0	0.1	REACTOME THROMBOXANE SIGNALLING THROUGH TP RECEPTOR	Genes involved in Thromboxane signalling through TP receptor
0.0	0.1	REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB	Genes involved in PKA-mediated phosphorylation of CREB
0.0	0.1	REACTOME UNWINDING OF DNA	Genes involved in Unwinding of DNA
0.0	0.2	REACTOME SIGNALING BY ROBO RECEPTOR	Genes involved in Signaling by Robo receptor
0.0	0.2	REACTOME ACTIVATION OF GENES BY ATF4	Genes involved in Activation of Genes by ATF4
0.0	0.0	REACTOME DESTABILIZATION OF MRNA BY BRF1	Genes involved in Destabilization of mRNA by Butyrate Response Factor 1 (BRF1)