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ENCSR904DTN: DNase-seq of mouse liver in constant darkness

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for Trp53

Z-value: 2.22

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Transcription factors associated with Trp53

Gene Symbol	Gene ID	Gene Info
Trp53 Ensembl NCBI MGI UniProt	ENSMUSG00000059552.7	Trp53

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

Gene	Promoter	Distance	Association probability	Pearson corr. coef.	P-value	Plot
Trp53	chr11_69581154_69581313	828	0.278397	0.88	1.9e-02	Click!
Trp53	chr11_69581695_69581992	1438	0.162179	0.47	3.5e-01	Click!
Trp53	chr11_69580921_69581079	595	0.368016	-0.42	4.0e-01	Click!
Trp53	chr11_69581394_69581562	1073	0.216896	0.21	6.9e-01	Click!
Trp53	chr11_69580228_69580399	46	0.493867	0.12	8.2e-01	Click!

Activity of the Trp53 motif across conditions

Conditions sorted by the z-value of the Trp53 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr16_30525931_30526082	0.65	Tmem44	transmembrane protein 44	14903	0.19
chr15_62039115_62039319	0.57	Pvt1	Pvt1 oncogene	40	0.98
chr13_25701872_25702071	0.56	Gm11350	predicted gene 11350	20828	0.27
chr6_88003582_88003770	0.55	4933412L11Rik	RIKEN cDNA 4933412L11 gene	9497	0.09
chr2_157471421_157471583	0.52	Src	Rous sarcoma oncogene	14417	0.16
chr15_11011259_11011438	0.51	Slc45a2	solute carrier family 45, member 2	10627	0.16
chr6_147950991_147951177	0.46	Far2	fatty acyl CoA reductase 2	96175	0.07
chr13_93627456_93627944	0.46	Gm15622	predicted gene 15622	2318	0.25
chr4_99227319_99227481	0.42	Atg4c	autophagy related 4C, cysteine peptidase	9309	0.19
chr4_137810112_137810287	0.41	Alpl	alkaline phosphatase, liver/bone/kidney	13815	0.19
chr5_32740717_32740884	0.41	Pisd	phosphatidylserine decarboxylase	54	0.95
chr6_135994801_135994964	0.40	Gm14330	predicted gene 14330	119377	0.06
chr3_132864626_132864788	0.39	Gm29811	predicted gene, 29811	13889	0.14
chr14_29672536_29672709	0.39	Cacna2d3	calcium channel, voltage-dependent, alpha2/delta subunit 3	49173	0.13
chr3_132860911_132861074	0.38	Gm29811	predicted gene, 29811	17604	0.14
chr18_60740746_60741116	0.38	Rps14	ribosomal protein S14	6167	0.16
chr14_69728721_69728885	0.38	Chmp7	charged multivesicular body protein 7	2072	0.22
chr10_68269443_68270351	0.37	Arid5b	AT rich interactive domain 5B (MRF1-like)	8824	0.23
chr3_121356225_121356399	0.37	Gm5711	predicted gene 5711	24367	0.14
chr17_8124666_8124826	0.37	Rnaset2a	ribonuclease T2A	23039	0.12
chr10_39406363_39406707	0.37	Fyn	Fyn proto-oncogene	13474	0.19
chr4_118362978_118363146	0.36	Hyi	hydroxypyruvate isomerase (putative)	1740	0.25
chr3_145591903_145592058	0.36	Znhit6	zinc finger, HIT type 6	3888	0.24
chr11_117203569_117203863	0.36	Septin9	septin 9	4055	0.2
chr16_10539600_10539751	0.36	Dexi	dexamethasone-induced transcript	3379	0.22
chr3_133765600_133766533	0.36	Gm6135	prediticted gene 6135	25438	0.2
chr17_7001922_7002085	0.36	Rnaset2b	ribonuclease T2B	11347	0.13
chr1_5072181_5072333	0.35	Rgs20	regulator of G-protein signaling 20	1972	0.26
chr7_49420191_49420342	0.34	Nav2	neuron navigator 2	30494	0.19
chr1_5071962_5072114	0.34	Rgs20	regulator of G-protein signaling 20	1753	0.28
chr4_55014920_55015072	0.34	Zfp462	zinc finger protein 462	3516	0.32
chr2_158629836_158630021	0.34	Actr5	ARP5 actin-related protein 5	1701	0.24
chr11_16857621_16857825	0.34	Egfr	epidermal growth factor receptor	20427	0.18
chr7_141184840_141184997	0.33	Gm22019	predicted gene, 22019	3607	0.09
chr18_53824107_53824451	0.33	Csnk1g3	casein kinase 1, gamma 3	37843	0.2
chr12_104901402_104901556	0.33	Gm28875	predicted gene 28875	25210	0.14
chr2_25194509_25194660	0.33	Tor4a	torsin family 4, member A	2175	0.1
chr11_103047839_103047990	0.33	Nmt1	N-myristoyltransferase 1	19329	0.1
chr1_93210442_93210625	0.33	Sned1	sushi, nidogen and EGF-like domains 1	25308	0.11
chr8_11373743_11373894	0.32	Col4a2	collagen, type IV, alpha 2	31090	0.13
chr6_50363496_50363647	0.32	Osbpl3	oxysterol binding protein-like 3	6644	0.27
chr19_3881058_3881209	0.32	Chka	choline kinase alpha	5728	0.09
chr3_123128727_123129043	0.32	Synpo2	synaptopodin 2	11833	0.14
chr2_151977784_151977939	0.32	Fam110a	family with sequence similarity 110, member A	2358	0.21
chr6_5045977_5046153	0.32	Ppp1r9a	protein phosphatase 1, regulatory subunit 9A	64594	0.1
chr14_64198612_64198817	0.32	9630015K15Rik	RIKEN cDNA 9630015K15 gene	82400	0.07
chr4_135780360_135780511	0.32	Myom3	myomesin family, member 3	17755	0.12
chr19_24268067_24268282	0.31	Fxn	frataxin	9997	0.17
chr5_34346535_34346723	0.31	Rnf4	ring finger protein 4	4487	0.15
chr13_92660201_92660368	0.31	Serinc5	serine incorporator 5	45498	0.14
chr9_102639370_102639523	0.31	Anapc13	anaphase promoting complex subunit 13	10934	0.13
chr4_130129683_130130093	0.31	Hcrtr1	hypocretin (orexin) receptor 1	7740	0.15
chr12_25817244_25817410	0.31	Gm9321	predicted gene 9321	3214	0.34
chr12_7990141_7990303	0.31	Apob	apolipoprotein B	12443	0.21
chr7_80653537_80653707	0.31	Gm15880	predicted gene 15880	17605	0.15
chr2_71719599_71719934	0.31	Platr26	pluripotency associated transcript 26	349	0.83
chr1_136142734_136142885	0.31	Kif21b	kinesin family member 21B	11355	0.11
chr11_120005928_120006087	0.30	Aatk	apoptosis-associated tyrosine kinase	6401	0.11
chr16_77434703_77434862	0.30	9430053O09Rik	RIKEN cDNA 9430053O09 gene	12962	0.11
chr4_108754553_108754711	0.30	Gm12741	predicted gene 12741	22890	0.12
chr2_84626485_84626636	0.30	Ctnnd1	catenin (cadherin associated protein), delta 1	11545	0.1
chr11_99177164_99177321	0.30	Ccr7	chemokine (C-C motif) receptor 7	22165	0.13
chr14_63822463_63822616	0.30	Xkr6	X-linked Kx blood group related 6	27520	0.17
chr6_126806165_126806322	0.30	Gm29788	predicted gene, 29788	1873	0.27
chr5_119054472_119054644	0.30	1700081H04Rik	RIKEN cDNA 1700081H04 gene	53676	0.13
chr16_10436240_10436428	0.30	Tvp23a	trans-golgi network vesicle protein 23A	7073	0.16
chr2_103028308_103028465	0.30	Pdhx	pyruvate dehydrogenase complex, component X	44949	0.13
chr1_127400359_127400512	0.30	Gm38301	predicted gene, 38301	6341	0.21
chr2_84937644_84937820	0.30	Slc43a3	solute carrier family 43, member 3	842	0.5
chr5_114806082_114806287	0.29	Ankrd13a	ankyrin repeat domain 13a	6613	0.09
chr4_148427588_148427746	0.29	Gm23303	predicted gene, 23303	15818	0.13
chr5_103737634_103737904	0.29	Aff1	AF4/FMR2 family, member 1	16393	0.19
chr5_140438868_140439039	0.29	Eif3b	eukaryotic translation initiation factor 3, subunit B	989	0.42
chr15_64195944_64196287	0.29	Asap1	ArfGAP with SH3 domain, ankyrin repeat and PH domain1	12376	0.24
chr3_138291566_138291979	0.28	Adh1	alcohol dehydrogenase 1 (class I)	14121	0.11
chr13_64314711_64314862	0.28	Prxl2c	peroxiredoxin like 2C	2076	0.17
chr18_56490748_56490899	0.28	Gramd3	GRAM domain containing 3	21556	0.14
chr7_145056434_145056606	0.28	Gm45181	predicted gene 45181	106476	0.05
chr9_44665366_44665550	0.28	Gm3953	predicted gene 3953	742	0.4
chr5_114596263_114596414	0.28	Fam222a	family with sequence similarity 222, member A	28321	0.12
chr2_93432778_93432949	0.28	Mir7001	microRNA 7001	10856	0.15
chr14_63145558_63145861	0.28	Ctsb	cathepsin B	10191	0.13
chr5_140831353_140831504	0.27	Gna12	guanine nucleotide binding protein, alpha 12	997	0.6
chr5_123364346_123364497	0.27	5830487J09Rik	RIKEN cDNA 5830487J09 gene	2051	0.15
chr8_11305954_11306113	0.27	Col4a1	collagen, type IV, alpha 1	6656	0.17
chr17_33539247_33539403	0.27	Adamts10	a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 10	1606	0.31
chr6_133960296_133960447	0.27	Gm8956	predicted gene 8956	27962	0.17
chr13_29769741_29769892	0.27	Cdkal1	CDK5 regulatory subunit associated protein 1-like 1	85615	0.1
chr6_121069331_121069498	0.27	Gm4651	predicted gene 4651	4818	0.19
chr3_152754407_152754729	0.27	Pigk	phosphatidylinositol glycan anchor biosynthesis, class K	8813	0.21
chr7_140383247_140383438	0.27	Gm6376	predicted gene 6376	3002	0.12
chr4_118149267_118149447	0.27	Kdm4a	lysine (K)-specific demethylase 4A	2598	0.22
chr15_74784791_74785147	0.27	Gm17189	predicted gene 17189	904	0.33
chr5_74660839_74660990	0.26	Lnx1	ligand of numb-protein X 1	16715	0.17
chr13_56324320_56324471	0.26	Gm17878	predicted gene, 17878	4061	0.17
chr3_100485827_100486059	0.26	Tent5c	terminal nucleotidyltransferase 5C	3251	0.18
chr13_93626823_93626974	0.26	Gm15622	predicted gene 15622	1516	0.35
chr8_111820161_111820326	0.26	Cfdp1	craniofacial development protein 1	34048	0.13
chr10_127632738_127633305	0.26	Gm48815	predicted gene, 48815	3366	0.11
chr17_66041118_66041288	0.26	Ankrd12	ankyrin repeat domain 12	35261	0.1
chr16_30057093_30057267	0.26	Hes1	hes family bHLH transcription factor 1	7204	0.16
chr12_79347763_79347934	0.26	Rad51b	RAD51 paralog B	20495	0.2
chr6_119643983_119644181	0.26	Erc1	ELKS/RAB6-interacting/CAST family member 1	21977	0.22
chr1_64791430_64791588	0.26	Plekhm3	pleckstrin homology domain containing, family M, member 3	45255	0.11
chr10_41796051_41796202	0.26	Cep57l1	centrosomal protein 57-like 1	13481	0.15
chr7_98312602_98312888	0.26	Acer3	alkaline ceramidase 3	3207	0.25
chr5_33574701_33574864	0.26	Fam53a	family with sequence similarity 53, member A	54130	0.08
chr7_142375895_142376054	0.25	Ifitm10	interferon induced transmembrane protein 10	2221	0.16
chr4_33244314_33244465	0.25	Pnrc1	proline-rich nuclear receptor coactivator 1	3186	0.21
chr13_34281709_34281879	0.25	Gm47086	predicted gene, 47086	37014	0.14
chr12_103362325_103362476	0.25	Gm45777	predicted gene 45777	6372	0.11
chr5_27411249_27411405	0.25	Speer4b	spermatogenesis associated glutamate (E)-rich protein 4B	90035	0.09
chr18_76000614_76000773	0.25	1700003O11Rik	RIKEN cDNA 1700003O11 gene	14984	0.23
chr12_86799109_86799540	0.25	Gm10095	predicted gene 10095	47143	0.11
chr14_30934111_30934339	0.25	Itih1	inter-alpha trypsin inhibitor, heavy chain 1	9052	0.1
chr13_70967895_70968046	0.25	8030423J24Rik	RIKEN cDNA 8030423J24 gene	85022	0.08
chr19_12457466_12457644	0.25	Mpeg1	macrophage expressed gene 1	3224	0.15
chr1_136704194_136704370	0.25	Gm24086	predicted gene, 24086	6908	0.14
chr8_104831387_104831616	0.25	Ces2b	carboxyesterase 2B	71	0.94
chr9_74884431_74884582	0.24	Onecut1	one cut domain, family member 1	18022	0.15
chr19_60941165_60941317	0.24	Gm9529	predicted gene 9529	26011	0.14
chr6_38186452_38186609	0.24	D630045J12Rik	RIKEN cDNA D630045J12 gene	7892	0.2
chr6_91525048_91525199	0.24	Gm45216	predicted gene 45216	2714	0.17
chr14_65682096_65682315	0.24	Scara5	scavenger receptor class A, member 5	5728	0.25
chr7_66371115_66371303	0.24	Gm23957	predicted gene, 23957	728	0.56
chr1_58891620_58891795	0.24	Gm28802	predicted gene 28802	1085	0.48
chr6_77240615_77240802	0.24	Lrrtm1	leucine rich repeat transmembrane neuronal 1	1981	0.43
chr3_151840491_151840642	0.24	Ptgfr	prostaglandin F receptor	2936	0.22
chr2_116932327_116932524	0.24	D330050G23Rik	RIKEN cDNA D330050G23 gene	32231	0.13
chr6_54767552_54767839	0.24	Znrf2	zinc and ring finger 2	49221	0.12
chr6_6538473_6538631	0.24	Sem1	SEM1, 26S proteasome complex subunit	40106	0.14
chr12_78842565_78842734	0.24	Atp6v1d	ATPase, H+ transporting, lysosomal V1 subunit D	2742	0.23
chr8_83104070_83104221	0.24	Gm45449	predicted gene 45449	17188	0.2
chrX_42018134_42018310	0.24	Xiap	X-linked inhibitor of apoptosis	41457	0.14
chr9_114716436_114716587	0.24	Cmtm6	CKLF-like MARVEL transmembrane domain containing 6	14605	0.15
chr13_63665698_63665976	0.24	Gm47387	predicted gene, 47387	4040	0.18
chr7_45574063_45574214	0.24	Bcat2	branched chain aminotransferase 2, mitochondrial	962	0.22
chr6_86145033_86145200	0.24	Gm19596	predicted gene, 19596	2036	0.27
chr11_20370399_20370788	0.24	Gm12033	predicted gene 12033	34580	0.15
chr2_173531317_173531484	0.24	1700021F07Rik	RIKEN cDNA 1700021F07 gene	8814	0.21
chr15_25623084_25623317	0.23	Myo10	myosin X	651	0.7
chr12_80947275_80947910	0.23	Srsf5	serine and arginine-rich splicing factor 5	1216	0.34
chr9_34735078_34735235	0.23	Kirrel3os	kirre like nephrin family adhesion molecule 3, opposite strand	194353	0.03
chr18_46714530_46714763	0.23	Cdo1	cysteine dioxygenase 1, cytosolic	13383	0.13
chr4_139614424_139614599	0.23	Aldh4a1	aldehyde dehydrogenase 4 family, member A1	8355	0.14
chr11_58969062_58969229	0.23	Trim17	tripartite motif-containing 17	5343	0.07
chr14_70395125_70395415	0.23	Gm22725	predicted gene, 22725	27010	0.09
chr16_87512452_87512619	0.23	Gm24891	predicted gene, 24891	15630	0.12
chr9_65299789_65300058	0.23	Gm16218	predicted gene 16218	2004	0.18
chr2_72741921_72742104	0.23	6430710C18Rik	RIKEN cDNA 6430710C18 gene	8841	0.22
chr6_35333770_35333951	0.23	1700065J11Rik	RIKEN cDNA 1700065J11 gene	3014	0.23
chr5_145983671_145983967	0.23	Cyp3a25	cytochrome P450, family 3, subfamily a, polypeptide 25	7824	0.13
chr2_13235859_13236020	0.23	Gm37160	predicted gene, 37160	4688	0.22
chr9_53344725_53344910	0.23	Exph5	exophilin 5	3628	0.22
chr1_60899201_60899544	0.23	Rpl18-ps1	ribosomal protein L18, pseudogene 1	1526	0.31
chr11_31771118_31771290	0.23	D630024D03Rik	RIKEN cDNA D630024D03 gene	53269	0.12
chr12_32829679_32829842	0.23	Nampt	nicotinamide phosphoribosyltransferase	8959	0.2
chr11_81370503_81370687	0.23	4930527B05Rik	RIKEN cDNA 4930527B05 gene	14418	0.29
chr16_23272256_23272412	0.23	St6gal1	beta galactoside alpha 2,6 sialyltransferase 1	2705	0.23
chr12_111454567_111454858	0.23	Tnfaip2	tumor necrosis factor, alpha-induced protein 2	4193	0.14
chr18_80468518_80468718	0.23	Gm50209	predicted gene, 50209	239	0.87
chr17_27587363_27587662	0.23	Nudt3	nudix (nucleotide diphosphate linked moiety X)-type motif 3	4193	0.1
chr2_163685840_163686012	0.23	Gm16316	predicted gene 16316	6353	0.15
chr6_86003630_86003791	0.22	4930553P18Rik	RIKEN cDNA 4930553P18 gene	670	0.54
chr4_128840187_128840338	0.22	Gm12968	predicted gene 12968	5935	0.17
chr12_44248581_44248746	0.22	Gm47096	predicted gene, 47096	20455	0.12
chr2_132123048_132123340	0.22	Slc23a2	solute carrier family 23 (nucleobase transporters), member 2	11746	0.16
chr5_118010944_118011095	0.22	Gm42545	predicted gene 42545	16351	0.13
chr3_65935257_65935428	0.22	Gm37037	predicted gene, 37037	1434	0.3
chr1_172296958_172297109	0.22	Atp1a2	ATPase, Na+/K+ transporting, alpha 2 polypeptide	1031	0.37
chr9_70761117_70761279	0.22	Adam10	a disintegrin and metallopeptidase domain 10	14855	0.2
chr16_86824945_86825096	0.22	Gm32624	predicted gene, 32624	8146	0.19
chr3_65533694_65533867	0.22	4931440P22Rik	RIKEN cDNA 4931440P22 gene	4401	0.15
chr17_55511801_55511952	0.22	St6gal2	beta galactoside alpha 2,6 sialyltransferase 2	65632	0.11
chr5_137828792_137828976	0.22	Pilra	paired immunoglobin-like type 2 receptor alpha	2626	0.12
chr2_129526434_129526601	0.22	F830045P16Rik	RIKEN cDNA F830045P16 gene	10085	0.16
chr4_154705761_154705932	0.22	Actrt2	actin-related protein T2	37979	0.12
chr12_3344324_3344475	0.22	Gm26520	predicted gene, 26520	12754	0.13
chr2_104131753_104132101	0.22	A930018P22Rik	RIKEN cDNA A930018P22 gene	9158	0.14
chr4_118152144_118152311	0.22	Kdm4a	lysine (K)-specific demethylase 4A	5468	0.16
chr14_70575919_70576089	0.22	Nudt18	nudix (nucleoside diphosphate linked moiety X)-type motif 18	1633	0.23
chr10_121485281_121485446	0.22	Gm40787	predicted gene, 40787	3623	0.14
chr3_92440282_92440451	0.22	Sprr1b	small proline-rich protein 1B	1577	0.18
chr3_86135244_86135409	0.22	Snord73a	small nucleolar RNA, C/D box U73A	3532	0.12
chr6_141879515_141879720	0.22	Gm30784	predicted gene, 30784	13259	0.2
chr5_123025352_123025521	0.22	Orai1	ORAI calcium release-activated calcium modulator 1	10098	0.08
chr11_6389224_6389393	0.22	Zmiz2	zinc finger, MIZ-type containing 2	56	0.95
chr10_84054746_84054912	0.22	Gm37908	predicted gene, 37908	6929	0.2
chr11_102263318_102263476	0.21	Hrob	homologous recombination factor with OB-fold	1433	0.24
chr19_10940905_10941056	0.21	Ptgdr2	prostaglandin D2 receptor 2	3820	0.12
chr14_51008118_51008288	0.21	Rnase10	ribonuclease, RNase A family, 10 (non-active)	274	0.8
chr7_19876833_19877030	0.21	Gm44659	predicted gene 44659	5493	0.08
chr18_21372400_21372792	0.21	Gm22886	predicted gene, 22886	8335	0.2
chr8_109667901_109668069	0.21	Ist1	increased sodium tolerance 1 homolog (yeast)	9609	0.15
chr10_71252490_71252774	0.21	Ube2d1	ubiquitin-conjugating enzyme E2D 1	4256	0.15
chr17_56687946_56688097	0.21	Ranbp3	RAN binding protein 3	8714	0.11
chr14_25793517_25793703	0.21	Gm27185	predicted gene 27185	16271	0.13
chr13_47215938_47216142	0.21	Rnf144b	ring finger protein 144B	22215	0.17
chr3_10129292_10129733	0.21	Gm37308	predicted gene, 37308	39557	0.1
chr5_113152964_113153205	0.21	Gm42161	predicted gene, 42161	7756	0.11

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of Trp53

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.2	GO:0071332	cellular response to fructose stimulus(GO:0071332)
0.1	0.2	GO:1903800	positive regulation of production of miRNAs involved in gene silencing by miRNA(GO:1903800)
0.1	0.2	GO:0035771	interleukin-4-mediated signaling pathway(GO:0035771)
0.1	0.3	GO:0002606	positive regulation of dendritic cell antigen processing and presentation(GO:0002606)
0.1	0.2	GO:0007084	mitotic nuclear envelope reassembly(GO:0007084)
0.1	0.2	GO:0034184	positive regulation of maintenance of sister chromatid cohesion(GO:0034093) positive regulation of maintenance of mitotic sister chromatid cohesion(GO:0034184)
0.1	0.2	GO:0010510	regulation of acetyl-CoA biosynthetic process from pyruvate(GO:0010510)
0.1	0.2	GO:0002159	desmosome assembly(GO:0002159)
0.1	0.2	GO:0060300	regulation of cytokine activity(GO:0060300)
0.1	0.2	GO:2000304	positive regulation of sphingolipid biosynthetic process(GO:0090154) positive regulation of ceramide biosynthetic process(GO:2000304)
0.0	0.1	GO:0021564	vagus nerve development(GO:0021564)
0.0	0.2	GO:0021555	midbrain-hindbrain boundary morphogenesis(GO:0021555)
0.0	0.1	GO:0018197	peptidyl-aspartic acid modification(GO:0018197)
0.0	0.1	GO:0009051	pentose-phosphate shunt, oxidative branch(GO:0009051)
0.0	0.3	GO:0006646	phosphatidylethanolamine biosynthetic process(GO:0006646)
0.0	0.0	GO:0033122	negative regulation of purine nucleotide catabolic process(GO:0033122)
0.0	0.2	GO:1902093	positive regulation of sperm motility(GO:1902093)
0.0	0.1	GO:0006203	dGTP catabolic process(GO:0006203)
0.0	0.2	GO:0043102	amino acid salvage(GO:0043102) L-methionine biosynthetic process(GO:0071265) L-methionine salvage(GO:0071267)
0.0	0.1	GO:2000321	positive regulation of T-helper 17 cell differentiation(GO:2000321)
0.0	0.2	GO:0006987	activation of signaling protein activity involved in unfolded protein response(GO:0006987)
0.0	0.1	GO:0060700	regulation of ribonuclease activity(GO:0060700)
0.0	0.1	GO:0030920	N-terminal peptidyl-serine acetylation(GO:0017198) N-terminal peptidyl-glutamic acid acetylation(GO:0018002) peptidyl-serine acetylation(GO:0030920)
0.0	0.1	GO:1903279	regulation of calcium:sodium antiporter activity(GO:1903279)
0.0	0.1	GO:0021776	smoothened signaling pathway involved in ventral spinal cord interneuron specification(GO:0021775) smoothened signaling pathway involved in spinal cord motor neuron cell fate specification(GO:0021776)
0.0	0.1	GO:1904395	regulation of skeletal muscle acetylcholine-gated channel clustering(GO:1904393) positive regulation of skeletal muscle acetylcholine-gated channel clustering(GO:1904395)
0.0	0.2	GO:0033564	anterior/posterior axon guidance(GO:0033564)
0.0	0.1	GO:0015772	disaccharide transport(GO:0015766) sucrose transport(GO:0015770) oligosaccharide transport(GO:0015772)
0.0	0.2	GO:0075525	viral translational termination-reinitiation(GO:0075525)
0.0	0.1	GO:1900169	regulation of glucocorticoid mediated signaling pathway(GO:1900169)
0.0	0.1	GO:1902498	regulation of protein autoubiquitination(GO:1902498)
0.0	0.1	GO:0043152	induction of bacterial agglutination(GO:0043152)
0.0	0.1	GO:1900126	negative regulation of hyaluronan biosynthetic process(GO:1900126)
0.0	0.0	GO:0032497	detection of lipopolysaccharide(GO:0032497)
0.0	0.1	GO:0051902	negative regulation of mitochondrial depolarization(GO:0051902)
0.0	0.1	GO:0051697	protein delipidation(GO:0051697)
0.0	0.1	GO:0019448	cysteine catabolic process(GO:0009093) L-cysteine catabolic process(GO:0019448) L-cysteine metabolic process(GO:0046439)
0.0	0.1	GO:1990705	cholangiocyte proliferation(GO:1990705)
0.0	0.2	GO:0015760	hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760)
0.0	0.1	GO:0006362	transcription elongation from RNA polymerase I promoter(GO:0006362)
0.0	0.1	GO:0045608	negative regulation of auditory receptor cell differentiation(GO:0045608)
0.0	0.2	GO:0090244	Wnt signaling pathway involved in somitogenesis(GO:0090244)
0.0	0.0	GO:2000668	dendritic cell apoptotic process(GO:0097048) regulation of dendritic cell apoptotic process(GO:2000668)
0.0	0.1	GO:1901525	negative regulation of macromitophagy(GO:1901525)
0.0	0.1	GO:0090038	negative regulation of protein kinase C signaling(GO:0090038)
0.0	0.2	GO:0071578	zinc II ion transmembrane import(GO:0071578)
0.0	0.1	GO:0072675	osteoclast fusion(GO:0072675)
0.0	0.1	GO:0007181	transforming growth factor beta receptor complex assembly(GO:0007181)
0.0	0.1	GO:0036091	positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress(GO:0036091)
0.0	0.1	GO:0061052	negative regulation of cell growth involved in cardiac muscle cell development(GO:0061052)
0.0	0.1	GO:2000721	positive regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation(GO:2000721)
0.0	0.1	GO:1902202	regulation of hepatocyte growth factor receptor signaling pathway(GO:1902202)
0.0	0.1	GO:0042117	monocyte activation(GO:0042117)
0.0	0.1	GO:1900740	regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900739) positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900740)
0.0	0.1	GO:0019230	proprioception(GO:0019230)
0.0	0.1	GO:0048254	snoRNA localization(GO:0048254)
0.0	0.2	GO:0061620	glycolytic process through glucose-6-phosphate(GO:0061620)
0.0	0.1	GO:0021914	negative regulation of smoothened signaling pathway involved in ventral spinal cord patterning(GO:0021914)
0.0	0.1	GO:1905097	regulation of guanyl-nucleotide exchange factor activity(GO:1905097)
0.0	0.2	GO:0060770	negative regulation of epithelial cell proliferation involved in prostate gland development(GO:0060770)
0.0	0.1	GO:0035461	vitamin transmembrane transport(GO:0035461)
0.0	0.2	GO:1900264	regulation of DNA-directed DNA polymerase activity(GO:1900262) positive regulation of DNA-directed DNA polymerase activity(GO:1900264)
0.0	0.1	GO:1904742	regulation of telomeric DNA binding(GO:1904742)
0.0	0.1	GO:0007296	vitellogenesis(GO:0007296)
0.0	0.1	GO:0018916	nitrobenzene metabolic process(GO:0018916)
0.0	0.1	GO:2000645	negative regulation of receptor catabolic process(GO:2000645)
0.0	0.1	GO:0031293	membrane protein intracellular domain proteolysis(GO:0031293)
0.0	0.1	GO:0016266	O-glycan processing(GO:0016266)
0.0	0.1	GO:0000379	tRNA-type intron splice site recognition and cleavage(GO:0000379)
0.0	0.0	GO:0019388	galactose catabolic process(GO:0019388)
0.0	0.1	GO:0015803	branched-chain amino acid transport(GO:0015803) leucine transport(GO:0015820)
0.0	0.1	GO:0061428	negative regulation of transcription from RNA polymerase II promoter in response to hypoxia(GO:0061428)
0.0	0.1	GO:0071879	positive regulation of adrenergic receptor signaling pathway(GO:0071879)
0.0	0.0	GO:0060748	tertiary branching involved in mammary gland duct morphogenesis(GO:0060748)
0.0	0.1	GO:0090230	regulation of centromere complex assembly(GO:0090230)
0.0	0.1	GO:1900104	hyaluranon cable assembly(GO:0036118) regulation of hyaluranon cable assembly(GO:1900104) positive regulation of hyaluranon cable assembly(GO:1900106)
0.0	0.0	GO:0010911	regulation of isomerase activity(GO:0010911) positive regulation of isomerase activity(GO:0010912)
0.0	0.1	GO:0042738	exogenous drug catabolic process(GO:0042738)
0.0	0.2	GO:0038063	collagen-activated tyrosine kinase receptor signaling pathway(GO:0038063)
0.0	0.1	GO:0006499	N-terminal protein myristoylation(GO:0006499)
0.0	0.1	GO:0007354	zygotic determination of anterior/posterior axis, embryo(GO:0007354)
0.0	0.1	GO:0009182	purine deoxyribonucleoside diphosphate metabolic process(GO:0009182) dGDP metabolic process(GO:0046066)
0.0	0.0	GO:0018992	germ-line sex determination(GO:0018992)
0.0	0.2	GO:0043353	enucleate erythrocyte differentiation(GO:0043353)
0.0	0.1	GO:0036066	protein O-linked fucosylation(GO:0036066)
0.0	0.0	GO:0097242	beta-amyloid clearance(GO:0097242)
0.0	0.1	GO:0045950	negative regulation of mitotic recombination(GO:0045950)
0.0	0.1	GO:1904220	regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity(GO:1904217) positive regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity(GO:1904219) regulation of serine C-palmitoyltransferase activity(GO:1904220) positive regulation of serine C-palmitoyltransferase activity(GO:1904222)
0.0	0.0	GO:0006501	C-terminal protein lipidation(GO:0006501)
0.0	0.1	GO:0030951	establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951)
0.0	0.1	GO:0052805	histidine catabolic process(GO:0006548) imidazole-containing compound catabolic process(GO:0052805)
0.0	0.1	GO:0009449	gamma-aminobutyric acid biosynthetic process(GO:0009449)
0.0	0.2	GO:0002585	positive regulation of antigen processing and presentation of peptide antigen(GO:0002585)
0.0	0.1	GO:0070094	positive regulation of glucagon secretion(GO:0070094)
0.0	0.1	GO:0032488	Cdc42 protein signal transduction(GO:0032488)
0.0	0.1	GO:0097212	lysosomal membrane organization(GO:0097212)
0.0	0.0	GO:1900186	negative regulation of clathrin-mediated endocytosis(GO:1900186)
0.0	0.1	GO:0045196	establishment or maintenance of neuroblast polarity(GO:0045196) establishment of neuroblast polarity(GO:0045200)
0.0	0.1	GO:0006116	NADH oxidation(GO:0006116)
0.0	0.1	GO:0070164	negative regulation of adiponectin secretion(GO:0070164)
0.0	0.1	GO:0006533	aspartate catabolic process(GO:0006533)
0.0	0.0	GO:0034136	negative regulation of toll-like receptor 2 signaling pathway(GO:0034136)
0.0	0.0	GO:0072050	S-shaped body morphogenesis(GO:0072050)
0.0	0.1	GO:0030423	targeting of mRNA for destruction involved in RNA interference(GO:0030423)
0.0	0.0	GO:0002461	tolerance induction dependent upon immune response(GO:0002461)
0.0	0.0	GO:0035435	phosphate ion transmembrane transport(GO:0035435)
0.0	0.1	GO:0045348	positive regulation of MHC class II biosynthetic process(GO:0045348)
0.0	0.1	GO:0006701	progesterone biosynthetic process(GO:0006701)
0.0	0.1	GO:0060729	intestinal epithelial structure maintenance(GO:0060729)
0.0	0.1	GO:1901503	ether lipid biosynthetic process(GO:0008611) glycerol ether biosynthetic process(GO:0046504) cellular lipid biosynthetic process(GO:0097384) ether biosynthetic process(GO:1901503)
0.0	0.1	GO:2000110	negative regulation of macrophage apoptotic process(GO:2000110)
0.0	0.0	GO:0010025	wax biosynthetic process(GO:0010025) wax metabolic process(GO:0010166)
0.0	0.1	GO:0044336	canonical Wnt signaling pathway involved in negative regulation of apoptotic process(GO:0044336)
0.0	0.2	GO:0070914	UV-damage excision repair(GO:0070914)
0.0	0.1	GO:0039534	negative regulation of MDA-5 signaling pathway(GO:0039534)
0.0	0.0	GO:0001732	formation of cytoplasmic translation initiation complex(GO:0001732)
0.0	0.1	GO:1901874	regulation of post-translational protein modification(GO:1901873) negative regulation of post-translational protein modification(GO:1901874)
0.0	0.1	GO:0036444	calcium ion transmembrane import into mitochondrion(GO:0036444)
0.0	0.0	GO:0045914	negative regulation of catecholamine metabolic process(GO:0045914) negative regulation of dopamine metabolic process(GO:0045963)
0.0	0.1	GO:0090286	cytoskeletal anchoring at nuclear membrane(GO:0090286)
0.0	0.1	GO:2000169	regulation of peptidyl-cysteine S-nitrosylation(GO:2000169)
0.0	0.1	GO:0002924	negative regulation of humoral immune response mediated by circulating immunoglobulin(GO:0002924)
0.0	0.1	GO:2000210	positive regulation of anoikis(GO:2000210)
0.0	0.1	GO:0034983	peptidyl-lysine deacetylation(GO:0034983)
0.0	0.1	GO:0002002	regulation of angiotensin levels in blood(GO:0002002)
0.0	0.0	GO:0021553	olfactory nerve development(GO:0021553)
0.0	0.0	GO:0048294	negative regulation of isotype switching to IgE isotypes(GO:0048294)
0.0	0.0	GO:0039689	negative stranded viral RNA replication(GO:0039689) multi-organism biosynthetic process(GO:0044034)
0.0	0.0	GO:0089700	protein kinase D signaling(GO:0089700)
0.0	0.2	GO:0006857	oligopeptide transport(GO:0006857)
0.0	0.1	GO:0000707	meiotic DNA recombinase assembly(GO:0000707)
0.0	0.0	GO:0006659	phosphatidylserine biosynthetic process(GO:0006659)
0.0	0.1	GO:0031468	nuclear envelope reassembly(GO:0031468)
0.0	0.4	GO:0051497	negative regulation of stress fiber assembly(GO:0051497)
0.0	0.0	GO:1900222	negative regulation of beta-amyloid clearance(GO:1900222)
0.0	0.0	GO:0036462	TRAIL-activated apoptotic signaling pathway(GO:0036462)
0.0	0.1	GO:1902018	negative regulation of cilium assembly(GO:1902018)
0.0	0.1	GO:1904424	regulation of GTP binding(GO:1904424)
0.0	0.0	GO:0010956	negative regulation of calcidiol 1-monooxygenase activity(GO:0010956)
0.0	0.2	GO:0051131	chaperone-mediated protein complex assembly(GO:0051131)
0.0	0.0	GO:0002513	tolerance induction to self antigen(GO:0002513)
0.0	0.2	GO:0001886	endothelial cell morphogenesis(GO:0001886)
0.0	0.2	GO:0000463	maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000463)
0.0	0.1	GO:0090168	Golgi reassembly(GO:0090168)
0.0	0.0	GO:0014734	skeletal muscle hypertrophy(GO:0014734)
0.0	0.1	GO:0060623	regulation of chromosome condensation(GO:0060623)
0.0	0.0	GO:0042276	error-prone translesion synthesis(GO:0042276)
0.0	0.0	GO:0071608	macrophage inflammatory protein-1 alpha production(GO:0071608)
0.0	0.0	GO:1904016	response to Thyroglobulin triiodothyronine(GO:1904016) cellular response to Thyroglobulin triiodothyronine(GO:1904017)
0.0	0.0	GO:0035973	aggrephagy(GO:0035973)
0.0	0.0	GO:0006741	NADP biosynthetic process(GO:0006741)
0.0	0.1	GO:0090385	phagosome-lysosome fusion(GO:0090385)
0.0	0.1	GO:0045714	regulation of low-density lipoprotein particle receptor biosynthetic process(GO:0045714)
0.0	0.1	GO:0009133	nucleoside diphosphate biosynthetic process(GO:0009133)
0.0	0.0	GO:0072309	mesenchymal stem cell maintenance involved in metanephric nephron morphogenesis(GO:0072309)
0.0	0.0	GO:0060061	Spemann organizer formation(GO:0060061)
0.0	0.1	GO:0001561	fatty acid alpha-oxidation(GO:0001561)
0.0	0.0	GO:0010520	regulation of reciprocal meiotic recombination(GO:0010520)
0.0	0.0	GO:0060847	endothelial cell fate specification(GO:0060847)
0.0	0.1	GO:0043097	pyrimidine-containing compound salvage(GO:0008655) pyrimidine nucleoside salvage(GO:0043097)
0.0	0.1	GO:0045651	positive regulation of macrophage differentiation(GO:0045651)
0.0	0.1	GO:0030643	cellular phosphate ion homeostasis(GO:0030643) cellular trivalent inorganic anion homeostasis(GO:0072502)
0.0	0.1	GO:0070586	cell-cell adhesion involved in gastrulation(GO:0070586)
0.0	0.1	GO:0002091	negative regulation of receptor internalization(GO:0002091)
0.0	0.1	GO:0043951	negative regulation of cAMP-mediated signaling(GO:0043951)
0.0	0.1	GO:0019087	transformation of host cell by virus(GO:0019087)
0.0	0.0	GO:1903587	regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:1903587)
0.0	0.0	GO:0061684	chaperone-mediated autophagy(GO:0061684)
0.0	0.1	GO:0006537	glutamate biosynthetic process(GO:0006537)
0.0	0.1	GO:0006265	DNA topological change(GO:0006265)
0.0	0.1	GO:0033762	response to glucagon(GO:0033762)
0.0	0.0	GO:0009233	menaquinone metabolic process(GO:0009233)
0.0	0.0	GO:0001560	regulation of cell growth by extracellular stimulus(GO:0001560)
0.0	0.1	GO:2000065	negative regulation of aldosterone metabolic process(GO:0032345) negative regulation of aldosterone biosynthetic process(GO:0032348) regulation of cortisol biosynthetic process(GO:2000064) negative regulation of cortisol biosynthetic process(GO:2000065)
0.0	0.0	GO:0016080	synaptic vesicle targeting(GO:0016080)
0.0	0.0	GO:0070779	D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
0.0	0.1	GO:1900084	regulation of peptidyl-tyrosine autophosphorylation(GO:1900084)
0.0	0.1	GO:1900165	negative regulation of interleukin-6 secretion(GO:1900165)
0.0	0.0	GO:0000098	sulfur amino acid catabolic process(GO:0000098)
0.0	0.1	GO:0038180	nerve growth factor signaling pathway(GO:0038180)
0.0	0.0	GO:0039536	negative regulation of RIG-I signaling pathway(GO:0039536)
0.0	0.1	GO:0044838	cell quiescence(GO:0044838)
0.0	0.1	GO:0015825	L-serine transport(GO:0015825)
0.0	0.0	GO:0051612	negative regulation of neurotransmitter uptake(GO:0051581) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612)
0.0	0.3	GO:0050435	beta-amyloid metabolic process(GO:0050435)
0.0	0.1	GO:0098535	de novo centriole assembly(GO:0098535)
0.0	0.0	GO:0060066	oviduct development(GO:0060066)
0.0	0.0	GO:0046208	spermine catabolic process(GO:0046208)
0.0	0.1	GO:0010992	ubiquitin homeostasis(GO:0010992)
0.0	0.1	GO:0043328	late endosome to vacuole transport via multivesicular body sorting pathway(GO:0032511) protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043328)
0.0	0.0	GO:0044778	meiotic DNA integrity checkpoint(GO:0044778)
0.0	0.1	GO:0061000	negative regulation of dendritic spine development(GO:0061000)
0.0	0.1	GO:0051573	negative regulation of histone H3-K9 methylation(GO:0051573)
0.0	0.1	GO:0030035	microspike assembly(GO:0030035)
0.0	0.1	GO:2001214	positive regulation of vasculogenesis(GO:2001214)
0.0	0.0	GO:0045590	negative regulation of regulatory T cell differentiation(GO:0045590)
0.0	0.0	GO:0015746	tricarboxylic acid transport(GO:0006842) citrate transport(GO:0015746)
0.0	0.2	GO:0051601	exocyst localization(GO:0051601)
0.0	0.0	GO:0060331	negative regulation of response to interferon-gamma(GO:0060331) negative regulation of interferon-gamma-mediated signaling pathway(GO:0060336)
0.0	0.2	GO:0002931	response to ischemia(GO:0002931)
0.0	0.1	GO:0034114	regulation of heterotypic cell-cell adhesion(GO:0034114)
0.0	0.0	GO:0010446	response to alkaline pH(GO:0010446)
0.0	0.0	GO:0060125	negative regulation of growth hormone secretion(GO:0060125)
0.0	0.1	GO:0030046	parallel actin filament bundle assembly(GO:0030046)
0.0	0.0	GO:1990123	L-glutamate(1-) import into cell(GO:1903802) L-glutamate import into cell(GO:1990123)
0.0	0.0	GO:0071799	response to prostaglandin D(GO:0071798) cellular response to prostaglandin D stimulus(GO:0071799)
0.0	0.0	GO:0006344	maintenance of chromatin silencing(GO:0006344)
0.0	0.1	GO:0009256	10-formyltetrahydrofolate metabolic process(GO:0009256)
0.0	0.0	GO:0015842	aminergic neurotransmitter loading into synaptic vesicle(GO:0015842) neurotransmitter loading into synaptic vesicle(GO:0098700)
0.0	0.1	GO:0021999	neural plate anterior/posterior regionalization(GO:0021999)
0.0	0.0	GO:1901668	regulation of superoxide dismutase activity(GO:1901668)
0.0	0.0	GO:0010728	regulation of hydrogen peroxide biosynthetic process(GO:0010728)
0.0	0.0	GO:0044339	canonical Wnt signaling pathway involved in osteoblast differentiation(GO:0044339)
0.0	0.0	GO:0034421	post-translational protein acetylation(GO:0034421)
0.0	0.1	GO:0016558	protein import into peroxisome matrix(GO:0016558)
0.0	0.0	GO:0000966	RNA 5'-end processing(GO:0000966)
0.0	0.1	GO:0003376	sphingosine-1-phosphate signaling pathway(GO:0003376)
0.0	0.1	GO:0060613	fat pad development(GO:0060613)
0.0	0.0	GO:0070934	CRD-mediated mRNA stabilization(GO:0070934)
0.0	0.0	GO:0090526	regulation of gluconeogenesis involved in cellular glucose homeostasis(GO:0090526)
0.0	0.1	GO:0000244	spliceosomal tri-snRNP complex assembly(GO:0000244)
0.0	0.0	GO:0009138	pyrimidine nucleoside diphosphate metabolic process(GO:0009138)
0.0	0.0	GO:0048293	isotype switching to IgE isotypes(GO:0048289) regulation of isotype switching to IgE isotypes(GO:0048293)
0.0	0.0	GO:0072697	protein localization to cell cortex(GO:0072697)
0.0	0.0	GO:0034638	phosphatidylcholine catabolic process(GO:0034638)
0.0	0.0	GO:0010624	regulation of Schwann cell proliferation(GO:0010624) negative regulation of Schwann cell proliferation(GO:0010626)
0.0	0.0	GO:0034755	iron ion transmembrane transport(GO:0034755)
0.0	0.1	GO:0071545	inositol phosphate catabolic process(GO:0071545)
0.0	0.1	GO:0050915	sensory perception of sour taste(GO:0050915)
0.0	0.0	GO:0006982	response to lipid hydroperoxide(GO:0006982)
0.0	0.0	GO:0006556	S-adenosylmethionine biosynthetic process(GO:0006556)
0.0	0.0	GO:0071947	protein deubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0071947)
0.0	0.0	GO:0002017	regulation of blood volume by renal aldosterone(GO:0002017)
0.0	0.0	GO:2000255	negative regulation of male germ cell proliferation(GO:2000255)
0.0	0.1	GO:0060385	axonogenesis involved in innervation(GO:0060385)
0.0	0.0	GO:0006481	C-terminal protein methylation(GO:0006481)
0.0	0.0	GO:1903553	positive regulation of extracellular exosome assembly(GO:1903553)
0.0	0.0	GO:0060005	vestibular reflex(GO:0060005)
0.0	0.0	GO:0075522	IRES-dependent viral translational initiation(GO:0075522)
0.0	0.1	GO:0060211	regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060211) positive regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060213)
0.0	0.0	GO:0010825	positive regulation of centrosome duplication(GO:0010825)
0.0	0.1	GO:0070945	neutrophil mediated killing of gram-negative bacterium(GO:0070945)
0.0	0.0	GO:0030579	ubiquitin-dependent SMAD protein catabolic process(GO:0030579)
0.0	0.1	GO:0061154	endothelial tube morphogenesis(GO:0061154)
0.0	0.0	GO:0060718	chorionic trophoblast cell differentiation(GO:0060718)
0.0	0.0	GO:0016480	negative regulation of transcription from RNA polymerase III promoter(GO:0016480)
0.0	0.0	GO:0090071	negative regulation of ribosome biogenesis(GO:0090071)
0.0	0.0	GO:0019695	choline metabolic process(GO:0019695)
0.0	0.0	GO:2000503	positive regulation of natural killer cell chemotaxis(GO:2000503)
0.0	0.0	GO:0097527	necroptotic signaling pathway(GO:0097527)
0.0	0.0	GO:0006543	glutamine catabolic process(GO:0006543)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.2	GO:0097487	multivesicular body, internal vesicle(GO:0097487)
0.1	0.2	GO:0005967	mitochondrial pyruvate dehydrogenase complex(GO:0005967)
0.0	0.1	GO:0005914	spot adherens junction(GO:0005914)
0.0	0.1	GO:0009331	glycerol-3-phosphate dehydrogenase complex(GO:0009331)
0.0	0.2	GO:0030670	phagocytic vesicle membrane(GO:0030670)
0.0	0.2	GO:0005663	DNA replication factor C complex(GO:0005663)
0.0	0.2	GO:0005587	collagen type IV trimer(GO:0005587) network-forming collagen trimer(GO:0098642) collagen network(GO:0098645) basement membrane collagen trimer(GO:0098651)
0.0	0.1	GO:0072559	NLRP3 inflammasome complex(GO:0072559)
0.0	0.1	GO:1990726	Lsm1-7-Pat1 complex(GO:1990726)
0.0	0.1	GO:0034274	Atg12-Atg5-Atg16 complex(GO:0034274)
0.0	0.1	GO:0034673	inhibin-betaglycan-ActRII complex(GO:0034673)
0.0	0.2	GO:0033180	proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.0	0.1	GO:0033093	Weibel-Palade body(GO:0033093)
0.0	0.1	GO:0005850	eukaryotic translation initiation factor 2 complex(GO:0005850)
0.0	0.2	GO:0071541	eukaryotic translation initiation factor 3 complex, eIF3m(GO:0071541)
0.0	0.1	GO:0008541	proteasome regulatory particle, lid subcomplex(GO:0008541)
0.0	0.1	GO:0016589	NURF complex(GO:0016589)
0.0	0.2	GO:0033116	endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116)
0.0	0.1	GO:0044322	endoplasmic reticulum quality control compartment(GO:0044322)
0.0	0.1	GO:0031415	NatA complex(GO:0031415)
0.0	0.1	GO:0000214	tRNA-intron endonuclease complex(GO:0000214)
0.0	0.1	GO:0030127	COPII vesicle coat(GO:0030127)
0.0	0.1	GO:0000220	vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220)
0.0	0.1	GO:0005577	fibrinogen complex(GO:0005577)
0.0	0.1	GO:0030485	smooth muscle contractile fiber(GO:0030485)
0.0	0.1	GO:0097443	sorting endosome(GO:0097443)
0.0	0.1	GO:0034992	microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.0	0.1	GO:1990604	IRE1-TRAF2-ASK1 complex(GO:1990604)
0.0	0.1	GO:0005712	chiasma(GO:0005712)
0.0	0.1	GO:0044316	cone cell pedicle(GO:0044316)
0.0	0.1	GO:0031466	Cul5-RING ubiquitin ligase complex(GO:0031466)
0.0	0.1	GO:0033010	paranodal junction(GO:0033010)
0.0	0.0	GO:0005899	insulin receptor complex(GO:0005899)
0.0	0.1	GO:0016272	prefoldin complex(GO:0016272)
0.0	0.1	GO:0043203	axon hillock(GO:0043203)
0.0	0.1	GO:0070937	CRD-mediated mRNA stability complex(GO:0070937)
0.0	0.1	GO:1990454	L-type voltage-gated calcium channel complex(GO:1990454)
0.0	0.0	GO:1990635	proximal dendrite(GO:1990635)
0.0	0.2	GO:0001527	microfibril(GO:0001527)
0.0	0.1	GO:0070761	pre-snoRNP complex(GO:0070761)
0.0	0.1	GO:0033063	Rad51B-Rad51C-Rad51D-XRCC2 complex(GO:0033063)
0.0	0.1	GO:0031983	vesicle lumen(GO:0031983)
0.0	0.1	GO:0000815	ESCRT III complex(GO:0000815)
0.0	0.1	GO:0042405	nuclear inclusion body(GO:0042405)
0.0	0.1	GO:0005638	lamin filament(GO:0005638)
0.0	0.1	GO:0030285	integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.0	0.0	GO:1990246	uniplex complex(GO:1990246)
0.0	0.0	GO:0071942	XPC complex(GO:0071942)
0.0	0.0	GO:0032937	SREBP-SCAP-Insig complex(GO:0032937)
0.0	0.0	GO:1990761	growth cone lamellipodium(GO:1990761)
0.0	0.2	GO:0035686	sperm fibrous sheath(GO:0035686)
0.0	0.0	GO:0031465	Cul4B-RING E3 ubiquitin ligase complex(GO:0031465)
0.0	0.0	GO:0097629	extrinsic component of omegasome membrane(GO:0097629)
0.0	0.1	GO:0042587	glycogen granule(GO:0042587)
0.0	0.1	GO:0061700	GATOR2 complex(GO:0061700)
0.0	0.0	GO:1990851	Wnt-Frizzled-LRP5/6 complex(GO:1990851)
0.0	0.0	GO:0017133	mitochondrial electron transfer flavoprotein complex(GO:0017133) electron transfer flavoprotein complex(GO:0045251)
0.0	0.0	GO:0044194	cytolytic granule(GO:0044194)
0.0	0.0	GO:1990923	PET complex(GO:1990923)
0.0	0.1	GO:0031315	extrinsic component of mitochondrial outer membrane(GO:0031315)
0.0	0.0	GO:0046691	intracellular canaliculus(GO:0046691)
0.0	0.1	GO:0030991	intraciliary transport particle A(GO:0030991)
0.0	0.1	GO:0071986	Ragulator complex(GO:0071986)
0.0	0.1	GO:1990124	messenger ribonucleoprotein complex(GO:1990124)
0.0	0.0	GO:0031265	CD95 death-inducing signaling complex(GO:0031265)
0.0	0.0	GO:0005745	m-AAA complex(GO:0005745)
0.0	0.0	GO:0071203	WASH complex(GO:0071203)
0.0	0.1	GO:0001650	fibrillar center(GO:0001650)
0.0	0.1	GO:0032580	Golgi cisterna membrane(GO:0032580)
0.0	0.0	GO:0045298	tubulin complex(GO:0045298)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.2	GO:0005006	epidermal growth factor-activated receptor activity(GO:0005006)
0.1	0.2	GO:0015563	uptake transmembrane transporter activity(GO:0015563)
0.1	0.2	GO:0008898	S-adenosylmethionine-homocysteine S-methyltransferase activity(GO:0008898)
0.1	0.2	GO:0031752	D5 dopamine receptor binding(GO:0031752)
0.1	0.2	GO:0004740	pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740)
0.1	0.2	GO:0004616	phosphogluconate dehydrogenase (decarboxylating) activity(GO:0004616)
0.0	0.1	GO:0015315	hexose phosphate transmembrane transporter activity(GO:0015119) organophosphate:inorganic phosphate antiporter activity(GO:0015315) hexose-phosphate:inorganic phosphate antiporter activity(GO:0015526) glucose 6-phosphate:inorganic phosphate antiporter activity(GO:0061513)
0.0	0.2	GO:0005042	netrin receptor activity(GO:0005042)
0.0	0.2	GO:0004305	ethanolamine kinase activity(GO:0004305)
0.0	0.1	GO:0090482	vitamin transmembrane transporter activity(GO:0090482)
0.0	0.2	GO:0015198	oligopeptide transporter activity(GO:0015198)
0.0	0.1	GO:1990190	peptide-serine-N-acetyltransferase activity(GO:1990189) peptide-glutamate-N-acetyltransferase activity(GO:1990190)
0.0	0.1	GO:1901702	urate transmembrane transporter activity(GO:0015143) salt transmembrane transporter activity(GO:1901702)
0.0	0.1	GO:0004367	glycerol-3-phosphate dehydrogenase [NAD+] activity(GO:0004367)
0.0	0.1	GO:0015154	sucrose:proton symporter activity(GO:0008506) sucrose transmembrane transporter activity(GO:0008515) disaccharide transmembrane transporter activity(GO:0015154) oligosaccharide transmembrane transporter activity(GO:0015157)
0.0	0.3	GO:0016861	intramolecular oxidoreductase activity, interconverting aldoses and ketoses(GO:0016861)
0.0	0.2	GO:0015093	ferrous iron transmembrane transporter activity(GO:0015093)
0.0	0.1	GO:0042895	antibiotic transporter activity(GO:0042895)
0.0	0.1	GO:0052658	inositol-1,4,5-trisphosphate 5-phosphatase activity(GO:0052658)
0.0	0.2	GO:0005384	manganese ion transmembrane transporter activity(GO:0005384)
0.0	0.1	GO:0004468	lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468)
0.0	0.1	GO:0030292	protein tyrosine kinase inhibitor activity(GO:0030292)
0.0	0.2	GO:0051864	histone demethylase activity (H3-K36 specific)(GO:0051864)
0.0	0.1	GO:0003917	DNA topoisomerase type I activity(GO:0003917)
0.0	0.1	GO:0001875	lipopolysaccharide receptor activity(GO:0001875)
0.0	0.1	GO:0032554	purine deoxyribonucleotide binding(GO:0032554)
0.0	0.1	GO:0033142	progesterone receptor binding(GO:0033142)
0.0	0.2	GO:0016889	endodeoxyribonuclease activity, producing 3'-phosphomonoesters(GO:0016889)
0.0	0.2	GO:0008440	inositol-1,4,5-trisphosphate 3-kinase activity(GO:0008440)
0.0	0.1	GO:0000213	tRNA-intron endonuclease activity(GO:0000213)
0.0	0.1	GO:0008486	diphosphoinositol-polyphosphate diphosphatase activity(GO:0008486)
0.0	0.2	GO:0004767	sphingomyelin phosphodiesterase activity(GO:0004767)
0.0	0.4	GO:0015026	coreceptor activity(GO:0015026)
0.0	0.1	GO:0034739	histone deacetylase activity (H4-K16 specific)(GO:0034739)
0.0	0.1	GO:0043199	sulfate binding(GO:0043199)
0.0	0.2	GO:0033170	DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.0	0.1	GO:0000405	bubble DNA binding(GO:0000405)
0.0	0.1	GO:0001025	RNA polymerase III transcription factor binding(GO:0001025)
0.0	0.1	GO:0019957	C-C chemokine binding(GO:0019957)
0.0	0.2	GO:0005522	profilin binding(GO:0005522)
0.0	0.1	GO:0004445	inositol-polyphosphate 5-phosphatase activity(GO:0004445)
0.0	0.1	GO:0001884	pyrimidine nucleoside binding(GO:0001884)
0.0	0.1	GO:0034648	histone demethylase activity (H3-dimethyl-K4 specific)(GO:0034648)
0.0	0.1	GO:0035473	lipase binding(GO:0035473)
0.0	0.1	GO:0001094	TFIID-class transcription factor binding(GO:0001094)
0.0	0.2	GO:0031432	titin binding(GO:0031432)
0.0	0.2	GO:0052687	3-oxo-2-(2'-pentenyl)cyclopentane-1-octanoic acid CoA ligase activity(GO:0010435) 3-isopropenyl-6-oxoheptanoyl-CoA synthetase activity(GO:0018854) 2-oxo-delta3-4,5,5-trimethylcyclopentenylacetyl-CoA synthetase activity(GO:0018855) benzoyl acetate-CoA ligase activity(GO:0018856) 2,4-dichlorobenzoate-CoA ligase activity(GO:0018857) pivalate-CoA ligase activity(GO:0034783) cyclopropanecarboxylate-CoA ligase activity(GO:0034793) adipate-CoA ligase activity(GO:0034796) citronellyl-CoA ligase activity(GO:0034823) mentha-1,3-dione-CoA ligase activity(GO:0034841) thiophene-2-carboxylate-CoA ligase activity(GO:0034842) 2,4,4-trimethylpentanoate-CoA ligase activity(GO:0034865) cis-2-methyl-5-isopropylhexa-2,5-dienoate-CoA ligase activity(GO:0034942) trans-2-methyl-5-isopropylhexa-2,5-dienoate-CoA ligase activity(GO:0034943) branched-chain acyl-CoA synthetase (ADP-forming) activity(GO:0043759) aryl-CoA synthetase (ADP-forming) activity(GO:0043762) 3-hydroxypropionyl-CoA synthetase activity(GO:0043955) perillic acid:CoA ligase (ADP-forming) activity(GO:0052685) perillic acid:CoA ligase (AMP-forming) activity(GO:0052686) (3R)-3-isopropenyl-6-oxoheptanoate:CoA ligase (ADP-forming) activity(GO:0052687) (3R)-3-isopropenyl-6-oxoheptanoate:CoA ligase (AMP-forming) activity(GO:0052688) pristanate-CoA ligase activity(GO:0070251) malonyl-CoA synthetase activity(GO:0090409)
0.0	0.1	GO:0048531	beta-1,3-galactosyltransferase activity(GO:0048531)
0.0	0.0	GO:0035877	death effector domain binding(GO:0035877)
0.0	0.1	GO:0002060	purine nucleobase binding(GO:0002060)
0.0	0.0	GO:0045504	dynein heavy chain binding(GO:0045504)
0.0	0.1	GO:0031995	insulin-like growth factor II binding(GO:0031995)
0.0	0.0	GO:0030144	alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity(GO:0030144)
0.0	0.1	GO:0016176	superoxide-generating NADPH oxidase activator activity(GO:0016176)
0.0	0.1	GO:0004528	phosphodiesterase I activity(GO:0004528)
0.0	0.0	GO:0004605	phosphatidate cytidylyltransferase activity(GO:0004605)
0.0	0.0	GO:0005128	erythropoietin receptor binding(GO:0005128)
0.0	0.1	GO:0005078	MAP-kinase scaffold activity(GO:0005078)
0.0	0.1	GO:0001013	RNA polymerase I regulatory region DNA binding(GO:0001013)
0.0	0.0	GO:1990460	leptin receptor binding(GO:1990460)
0.0	0.1	GO:0042609	CD4 receptor binding(GO:0042609)
0.0	0.0	GO:0004967	glucagon receptor activity(GO:0004967)
0.0	0.1	GO:0016443	bidentate ribonuclease III activity(GO:0016443)
0.0	0.1	GO:1990239	steroid hormone binding(GO:1990239)
0.0	0.1	GO:0004849	uridine kinase activity(GO:0004849)
0.0	0.0	GO:0016647	oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor(GO:0016647)
0.0	0.0	GO:0015222	serotonin transmembrane transporter activity(GO:0015222)
0.0	0.1	GO:0009374	biotin binding(GO:0009374)
0.0	0.1	GO:0047499	calcium-independent phospholipase A2 activity(GO:0047499)
0.0	0.1	GO:0004128	cytochrome-b5 reductase activity, acting on NAD(P)H(GO:0004128)
0.0	0.1	GO:0048406	nerve growth factor binding(GO:0048406)
0.0	0.1	GO:0015016	[heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.0	0.1	GO:0050308	sugar-phosphatase activity(GO:0050308)
0.0	0.0	GO:0004525	ribonuclease III activity(GO:0004525) double-stranded RNA-specific ribonuclease activity(GO:0032296)
0.0	0.0	GO:0043120	tumor necrosis factor binding(GO:0043120)
0.0	0.1	GO:0036122	BMP binding(GO:0036122)
0.0	0.1	GO:0044606	thiamine-pyrophosphatase activity(GO:0004787) UDP-2,3-diacylglucosamine hydrolase activity(GO:0008758) dATP pyrophosphohydrolase activity(GO:0008828) dihydroneopterin monophosphate phosphatase activity(GO:0019176) dihydroneopterin triphosphate pyrophosphohydrolase activity(GO:0019177) dTTP diphosphatase activity(GO:0036218) phosphocholine hydrolase activity(GO:0044606)
0.0	0.0	GO:0031686	A1 adenosine receptor binding(GO:0031686)
0.0	0.0	GO:0004942	anaphylatoxin receptor activity(GO:0004942)
0.0	0.0	GO:0032137	guanine/thymine mispair binding(GO:0032137)
0.0	0.0	GO:0001224	RNA polymerase II transcription cofactor binding(GO:0001224)
0.0	0.0	GO:0015142	citrate transmembrane transporter activity(GO:0015137) tricarboxylic acid transmembrane transporter activity(GO:0015142)
0.0	0.1	GO:0004706	JUN kinase kinase kinase activity(GO:0004706)
0.0	0.1	GO:0017034	Rap guanyl-nucleotide exchange factor activity(GO:0017034)
0.0	0.2	GO:0008553	hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.0	0.1	GO:0008420	CTD phosphatase activity(GO:0008420)
0.0	0.0	GO:0043888	4-hydroxybenzoate octaprenyltransferase activity(GO:0008412) protoheme IX farnesyltransferase activity(GO:0008495) (S)-2,3-di-O-geranylgeranylglyceryl phosphate synthase activity(GO:0043888) cadaverine aminopropyltransferase activity(GO:0043918) agmatine aminopropyltransferase activity(GO:0043919) 1,4-dihydroxy-2-naphthoate octaprenyltransferase activity(GO:0046428) trans-pentaprenyltranstransferase activity(GO:0048045) ATP dimethylallyltransferase activity(GO:0052622) ADP dimethylallyltransferase activity(GO:0052623)
0.0	0.0	GO:0071535	RING-like zinc finger domain binding(GO:0071535)
0.0	0.1	GO:0030957	Tat protein binding(GO:0030957)
0.0	0.1	GO:0070016	armadillo repeat domain binding(GO:0070016)
0.0	0.1	GO:0015194	L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889)
0.0	0.0	GO:0003986	acetyl-CoA hydrolase activity(GO:0003986)
0.0	0.1	GO:0050649	testosterone 6-beta-hydroxylase activity(GO:0050649)
0.0	0.0	GO:0050501	hyaluronan synthase activity(GO:0050501)
0.0	0.0	GO:0004558	alpha-1,4-glucosidase activity(GO:0004558)
0.0	0.0	GO:0005157	macrophage colony-stimulating factor receptor binding(GO:0005157)
0.0	0.1	GO:0008559	xenobiotic-transporting ATPase activity(GO:0008559)
0.0	0.1	GO:0017110	nucleoside-diphosphatase activity(GO:0017110)
0.0	0.0	GO:0015220	choline transmembrane transporter activity(GO:0015220)
0.0	0.1	GO:0005068	transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)

Gene overrepresentation in curated gene sets: canonical pathways category:

Total log-likelihood	Term	Description
0.4	PID SYNDECAN 3 PATHWAY	Syndecan-3-mediated signaling events
0.0	ST WNT CA2 CYCLIC GMP PATHWAY	Wnt/Ca2+/cyclic GMP signaling.
0.1	PID ECADHERIN KERATINOCYTE PATHWAY	E-cadherin signaling in keratinocytes
0.5	PID HNF3A PATHWAY	FOXA1 transcription factor network
0.3	PID IFNG PATHWAY	IFN-gamma pathway
0.1	PID CD8 TCR PATHWAY	TCR signaling in naïve CD8+ T cells
0.2	ST INTERLEUKIN 4 PATHWAY	Interleukin 4 (IL-4) Pathway
0.0	PID ERBB4 PATHWAY	ErbB4 signaling events
0.1	SA REG CASCADE OF CYCLIN EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.2	PID ARF 3PATHWAY	Arf1 pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Total log-likelihood	Term	Description
0.2	REACTOME BETA DEFENSINS	Genes involved in Beta defensins
0.2	REACTOME RNA POL I PROMOTER OPENING	Genes involved in RNA Polymerase I Promoter Opening
0.1	REACTOME XENOBIOTICS	Genes involved in Xenobiotics
0.0	REACTOME SOS MEDIATED SIGNALLING	Genes involved in SOS-mediated signalling
0.2	REACTOME PECAM1 INTERACTIONS	Genes involved in PECAM1 interactions
0.2	REACTOME HYALURONAN UPTAKE AND DEGRADATION	Genes involved in Hyaluronan uptake and degradation
0.3	REACTOME SHC1 EVENTS IN EGFR SIGNALING	Genes involved in SHC1 events in EGFR signaling
0.2	REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX	Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.2	REACTOME LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS	Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis
0.1	REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES	Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)
0.2	REACTOME GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTERGRINS	Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins
0.1	REACTOME ARMS MEDIATED ACTIVATION	Genes involved in ARMS-mediated activation
0.4	REACTOME INSULIN RECEPTOR RECYCLING	Genes involved in Insulin receptor recycling
0.2	REACTOME THE NLRP3 INFLAMMASOME	Genes involved in The NLRP3 inflammasome
0.0	REACTOME REGULATION OF INSULIN SECRETION BY GLUCAGON LIKE PEPTIDE1	Genes involved in Regulation of Insulin Secretion by Glucagon-like Peptide-1
0.0	REACTOME NRAGE SIGNALS DEATH THROUGH JNK	Genes involved in NRAGE signals death through JNK
0.0	REACTOME ACYL CHAIN REMODELLING OF PI	Genes involved in Acyl chain remodelling of PI
0.1	REACTOME SYNTHESIS OF PE	Genes involved in Synthesis of PE
0.1	REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS	Genes involved in Facilitative Na+-independent glucose transporters
0.0	REACTOME CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION	Genes involved in Cyclin E associated events during G1/S transition
0.3	REACTOME REGULATORY RNA PATHWAYS	Genes involved in Regulatory RNA pathways
0.1	REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS	Genes involved in Extrinsic Pathway for Apoptosis
0.0	REACTOME DESTABILIZATION OF MRNA BY BRF1	Genes involved in Destabilization of mRNA by Butyrate Response Factor 1 (BRF1)
0.2	REACTOME REPAIR SYNTHESIS FOR GAP FILLING BY DNA POL IN TC NER	Genes involved in Repair synthesis for gap-filling by DNA polymerase in TC-NER
0.1	REACTOME SIGNALING BY NOTCH2	Genes involved in Signaling by NOTCH2
0.1	REACTOME REGULATION OF IFNG SIGNALING	Genes involved in Regulation of IFNG signaling
0.3	REACTOME NETRIN1 SIGNALING	Genes involved in Netrin-1 signaling
0.2	REACTOME SIGNALING BY BMP	Genes involved in Signaling by BMP