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ENCSR904DTN: DNase-seq of mouse liver in constant darkness
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Results for Trp63

Z-value: 1.39

Motif logo

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Transcription factors associated with Trp63

Gene Symbol Gene ID Gene Info
Trp63
ENSMUSG00000022510.8 transformation related protein 63

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE Gene Distance Association probability Pearson corr. coef. P-value Plot
chr16_25875334_25875496Trp63734990.1027540.953.6e-03Click!
chr16_25876965_25877159Trp63751460.0996200.891.8e-02Click!
chr16_25805292_25805462Trp6334610.3313880.882.0e-02Click!
chr16_25876261_25876542Trp63744850.1008670.882.0e-02Click!
chr16_25804778_25805017Trp6329810.3516630.777.1e-02Click!

Activity of the Trp63 motif across conditions

Conditions sorted by the z-value of the Trp63 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE) Target Score Top associated gene Gene Info Distance of CRE to TSS CRE/Gene association probability
chr12_104083020_104083260 1.44 Serpina4-ps1
 serine (or cysteine) peptidase inhibitor, clade A, member 4, pseudogene 1
 2491
 0.16
chr5_125512652_125512844 1.11 Aacs
 acetoacetyl-CoA synthetase
 49
 0.97
chr1_88122933_88123203 1.08 Gm15372
 predicted gene 15372
 3708
 0.08
chr7_98355230_98355493 1.01 Tsku
 tsukushi, small leucine rich proteoglycan
 4718
 0.19
chr14_21181534_21181685 0.97 Adk
 adenosine kinase
 105457
 0.06
chr19_40184875_40185171 0.96 Cyp2c70
 cytochrome P450, family 2, subfamily c, polypeptide 70
 2263
 0.24
chr15_59015531_59015876 0.96 Mtss1
 MTSS I-BAR domain containing 1
 24893
 0.16
chr8_70476439_70476616 0.87 Klhl26
 kelch-like 26
 378
 0.72
chr7_99201987_99202161 0.79 Gm45012
 predicted gene 45012
 292
 0.86
chr7_98355533_98355727 0.77 Tsku
 tsukushi, small leucine rich proteoglycan
 4449
 0.2
chr15_3398924_3399075 0.71 Ghr
 growth hormone receptor
 72645
 0.11
chr5_140112771_140112922 0.67 Mad1l1
 MAD1 mitotic arrest deficient 1-like 1
 2620
 0.23
chr11_70501874_70502034 0.67 Tm4sf5
 transmembrane 4 superfamily member 5
 3290
 0.09
chr18_9842900_9843072 0.67 Gm23637
 predicted gene, 23637
 15867
 0.13
chr16_42911354_42911708 0.65 Gm19522
 predicted gene, 19522
 534
 0.77
chr12_75566070_75566284 0.65 Gm47689
 predicted gene, 47689
 13688
 0.18
chr4_134902978_134903198 0.64 Tmem50a
 transmembrane protein 50A
 11927
 0.14
chr11_11845438_11845699 0.63 Ddc
 dopa decarboxylase
 9288
 0.18
chr9_48722520_48722671 0.63 Zbtb16
 zinc finger and BTB domain containing 16
 113350
 0.05
chr16_18071409_18071560 0.59 Dgcr6
 DiGeorge syndrome critical region gene 6
 2004
 0.23
chr11_5530853_5531004 0.58 Xbp1
 X-box binding protein 1
 9005
 0.13
chr19_39282659_39282846 0.57 Cyp2c29
 cytochrome P450, family 2, subfamily c, polypeptide 29
 4322
 0.25
chr17_89646332_89646522 0.57 Gm50061
 predicted gene, 50061
 106099
 0.08
chr6_35873017_35873173 0.57 Gm43442
 predicted gene 43442
 53616
 0.16
chr8_104789386_104789560 0.56 Gm45782
 predicted gene 45782
 3645
 0.12
chr5_120481198_120481714 0.53 Gm15690
 predicted gene 15690
 553
 0.54
chr19_46056737_46057343 0.53 Pprc1
 peroxisome proliferative activated receptor, gamma, coactivator-related 1
 176
 0.92
chr11_16781411_16781603 0.52 Egfr
 epidermal growth factor receptor
 29277
 0.16
chr11_120816054_120816209 0.50 Fasn
 fatty acid synthase
 676
 0.49
chr5_92585412_92585563 0.50 Fam47e
 family with sequence similarity 47, member E
 13931
 0.15
chr11_16841273_16841607 0.49 Egfros
 epidermal growth factor receptor, opposite strand
 10738
 0.21
chr13_41202938_41203089 0.49 Elovl2
 elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 2
 17149
 0.11
chr10_87913477_87913628 0.49 Igf1os
 insulin-like growth factor 1, opposite strand
 50171
 0.11
chr7_19018429_19018664 0.49 Foxa3
 forkhead box A3
 4992
 0.08
chr3_138226457_138226622 0.48 Adh7
 alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide
 1512
 0.29
chr10_31595125_31595561 0.47 Rnf217
 ring finger protein 217
 13841
 0.16
chr6_95710009_95710160 0.47 Suclg2
 succinate-Coenzyme A ligase, GDP-forming, beta subunit
 8716
 0.32
chr9_53292248_53292436 0.47 Exph5
 exophilin 5
 9328
 0.19
chr6_100096782_100096939 0.47 2010109P13Rik
 RIKEN cDNA 2010109P13 gene
 46954
 0.15
chr14_64690169_64690374 0.46 Kif13b
 kinesin family member 13B
 37669
 0.15
chr11_68851235_68851391 0.46 Ndel1
 nudE neurodevelopment protein 1 like 1
 1728
 0.27
chr6_85868321_85868637 0.44 Nat8f2
 N-acetyltransferase 8 (GCN5-related) family member 2
 679
 0.48
chr11_5916279_5916587 0.43 Gm11967
 predicted gene 11967
 1118
 0.3
chr15_89077796_89078211 0.43 Trabd
 TraB domain containing
 1879
 0.16
chr2_134550332_134550521 0.42 Hao1
 hydroxyacid oxidase 1, liver
 3881
 0.35
chr6_149098639_149098790 0.42 Dennd5b
 DENN/MADD domain containing 5B
 2824
 0.16
chr2_24901182_24901348 0.42 Gm37139
 predicted gene, 37139
 7399
 0.1
chr6_90568851_90569300 0.41 Aldh1l1
 aldehyde dehydrogenase 1 family, member L1
 1369
 0.35
chr12_81167975_81168146 0.41 Mir3067
 microRNA 3067
 1909
 0.38
chr4_45852505_45852662 0.41 Stra6l
 STRA6-like
 3586
 0.2
chr6_82647878_82648248 0.40 Pole4
 polymerase (DNA-directed), epsilon 4 (p12 subunit)
 4455
 0.23
chr1_59157668_59157869 0.40 Mpp4
 membrane protein, palmitoylated 4 (MAGUK p55 subfamily member 4)
 893
 0.43
chr1_169165587_169165766 0.40 Mir6354
 microRNA 6354
 146587
 0.04
chr1_171168499_171168673 0.40 Mpz
 myelin protein zero
 8883
 0.09
chr8_109998736_109999105 0.40 Tat
 tyrosine aminotransferase
 8414
 0.12
chr2_158570467_158570618 0.39 Arhgap40
 Rho GTPase activating protein 40
 28805
 0.1
chr1_71723212_71723548 0.39 Gm5256
 predicted gene 5256
 8456
 0.19
chr4_95625117_95625268 0.39 Fggy
 FGGY carbohydrate kinase domain containing
 1636
 0.46
chr14_21256205_21256412 0.39 Adk
 adenosine kinase
 61817
 0.13
chr9_61809239_61809390 0.39 Gm19208
 predicted gene, 19208
 42390
 0.15
chr7_136457949_136458342 0.38 Gm36849
 predicted gene, 36849
 104781
 0.07
chr14_55147433_55147865 0.38 Gm23596
 predicted gene, 23596
 13959
 0.09
chr2_26593869_26594069 0.38 Egfl7
 EGF-like domain 7
 1822
 0.16
chr1_151131178_151131360 0.38 Gm8941
 predicted gene 8941
 5238
 0.13
chr9_57059997_57060182 0.37 Ptpn9
 protein tyrosine phosphatase, non-receptor type 9
 651
 0.62
chrX_60504109_60504260 0.37 Gm7073
 predicted gene 7073
 35065
 0.14
chr7_121652771_121652941 0.37 Usp31
 ubiquitin specific peptidase 31
 13959
 0.18
chr11_16589151_16589356 0.37 Gm12663
 predicted gene 12663
 46813
 0.12
chrX_161717217_161717797 0.37 Rai2
 retinoic acid induced 2
 120
 0.98
chr3_95882847_95883034 0.36 Ciart
 circadian associated repressor of transcription
 689
 0.44
chr1_136625692_136626183 0.36 Zfp281
 zinc finger protein 281
 1036
 0.34
chr15_10632975_10633126 0.36 Gm10389
 predicted gene 10389
 32713
 0.14
chr5_125478134_125478423 0.36 Gm27551
 predicted gene, 27551
 1099
 0.36
chr9_40804280_40804486 0.36 Hspa8
 heat shock protein 8
 101
 0.66
chr5_114155622_114155805 0.35 Acacb
 acetyl-Coenzyme A carboxylase beta
 9178
 0.12
chr2_160340207_160340432 0.35 Gm826
 predicted gene 826
 6157
 0.26
chr6_149344317_149344633 0.35 Gm15782
 predicted gene 15782
 9351
 0.14
chr9_115307686_115307849 0.35 Stt3b
 STT3, subunit of the oligosaccharyltransferase complex, homolog B (S. cerevisiae)
 2654
 0.24
chr8_85500511_85501282 0.34 Gpt2
 glutamic pyruvate transaminase (alanine aminotransferase) 2
 8287
 0.17
chr13_111895157_111895352 0.34 Gm9025
 predicted gene 9025
 11077
 0.15
chr18_74301601_74301911 0.34 Gm14328
 predicted gene 14328
 2175
 0.26
chr2_59160190_59160538 0.34 Ccdc148
 coiled-coil domain containing 148
 170
 0.8
chr10_37139807_37140183 0.34 5930403N24Rik
 RIKEN cDNA 5930403N24 gene
 81
 0.95
chr12_70198492_70198710 0.33 Pygl
 liver glycogen phosphorylase
 760
 0.59
chr6_58733664_58733815 0.33 Gm43899
 predicted gene, 43899
 48198
 0.13
chr6_108426569_108426787 0.33 Itpr1
 inositol 1,4,5-trisphosphate receptor 1
 8801
 0.22
chr11_6528187_6528435 0.33 Snora9
 small nucleolar RNA, H/ACA box 9
 146
 0.77
chr15_68363065_68363728 0.33 Gm20732
 predicted gene 20732
 220
 0.9
chr11_79878516_79878681 0.33 9130204K15Rik
 RIKEN cDNA 9130204K15 gene
 6204
 0.15
chrX_60400421_60400586 0.33 Atp11c
 ATPase, class VI, type 11C
 3478
 0.24
chr2_31514792_31514964 0.32 Ass1
 argininosuccinate synthetase 1
 3612
 0.21
chr13_73767240_73767553 0.32 Slc12a7
 solute carrier family 12, member 7
 3657
 0.21
chr12_16584004_16584353 0.32 Lpin1
 lipin 1
 5542
 0.26
chr4_148590620_148590972 0.32 Srm
 spermidine synthase
 707
 0.49
chr6_118478873_118479106 0.32 Zfp9
 zinc finger protein 9
 331
 0.85
chr4_10943152_10943325 0.32 Rps11-ps3
 ribosomal protein S11, pseudogene 3
 3370
 0.23
chr4_53073780_53074212 0.32 Abca1
 ATP-binding cassette, sub-family A (ABC1), member 1
 33070
 0.15
chr11_115418711_115418869 0.32 Atp5h
 ATP synthase, H+ transporting, mitochondrial F0 complex, subunit D
 49
 0.92
chr1_194360305_194360456 0.31 4930503O07Rik
 RIKEN cDNA 4930503O07 gene
 137621
 0.05
chr17_5232385_5232541 0.31 Gm15599
 predicted gene 15599
 120353
 0.05
chr5_99247519_99247696 0.31 Rasgef1b
 RasGEF domain family, member 1B
 4367
 0.26
chr8_24575832_24575983 0.31 Ido2
 indoleamine 2,3-dioxygenase 2
 426
 0.82
chr19_55110942_55111169 0.30 Gpam
 glycerol-3-phosphate acyltransferase, mitochondrial
 7964
 0.2
chr12_74320624_74320791 0.30 Gm34552
 predicted gene, 34552
 3545
 0.18
chr4_14805319_14805470 0.30 Lrrc69
 leucine rich repeat containing 69
 9334
 0.19
chr9_69226678_69226839 0.30 Rora
 RAR-related orphan receptor alpha
 31217
 0.22
chr12_87393286_87393480 0.30 Gm48873
 predicted gene, 48873
 1061
 0.3
chr4_119550388_119550568 0.30 Gm12959
 predicted gene 12959
 3580
 0.12
chr7_141092673_141092858 0.30 Sigirr
 single immunoglobulin and toll-interleukin 1 receptor (TIR) domain
 985
 0.3
chr12_80324041_80324208 0.30 Dcaf5
 DDB1 and CUL4 associated factor 5
 52568
 0.08
chr17_34853353_34853526 0.30 Nelfe
 negative elongation factor complex member E, Rdbp
 497
 0.46
chr5_112276946_112277327 0.30 Tpst2
 protein-tyrosine sulfotransferase 2
 429
 0.74
chr8_127111900_127112059 0.30 Pard3
 par-3 family cell polarity regulator
 38739
 0.16
chr5_122455478_122455753 0.30 Anapc7
 anaphase promoting complex subunit 7
 14240
 0.09
chr12_8811934_8812098 0.29 Sdc1
 syndecan 1
 40213
 0.13
chr1_130664035_130664240 0.29 C4bp
 complement component 4 binding protein
 2505
 0.18
chr1_191225182_191225346 0.29 D730003I15Rik
 RIKEN cDNA D730003I15 gene
 790
 0.54
chr12_28804906_28805226 0.29 Gm48905
 predicted gene, 48905
 5072
 0.18
chr13_75844352_75844786 0.29 Glrx
 glutaredoxin
 4493
 0.17
chr17_45957936_45958127 0.28 Gm49805
 predicted gene, 49805
 3828
 0.22
chr15_78947569_78947720 0.28 Triobp
 TRIO and F-actin binding protein
 80
 0.93
chr5_124233026_124233422 0.28 Pitpnm2os1
 phosphatidylinositol transfer protein, membrane-associated 2, opposite strand 1
 3499
 0.14
chr15_99042750_99042942 0.28 Prph
 peripherin
 12328
 0.08
chr14_118038826_118039199 0.28 Dct
 dopachrome tautomerase
 4117
 0.23
chr2_91930123_91930286 0.28 Mdk
 midkine
 1484
 0.25
chr12_77056757_77057146 0.28 Gm35189
 predicted gene, 35189
 14750
 0.21
chr10_80433536_80433845 0.28 Tcf3
 transcription factor 3
 43
 0.94
chr1_163150756_163150961 0.28 Gm22434
 predicted gene, 22434
 32631
 0.15
chr8_111693865_111694016 0.28 Ctrb1
 chymotrypsinogen B1
 2930
 0.21
chr12_76369660_76370048 0.28 Zbtb25
 zinc finger and BTB domain containing 25
 252
 0.62
chr14_51932437_51932626 0.28 Gm49076
 predicted gene, 49076
 2871
 0.12
chr5_138776683_138776881 0.27 Fam20c
 family with sequence similarity 20, member C
 9718
 0.19
chr1_76911315_76911480 0.27 Gm816
 predicted gene 816
 116395
 0.07
chr17_35814760_35815402 0.27 Ier3
 immediate early response 3
 6603
 0.07
chr19_55548698_55548991 0.27 Vti1a
 vesicle transport through interaction with t-SNAREs 1A
 167830
 0.03
chr9_30855695_30855884 0.27 Adamts15
 a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 15
 53868
 0.12
chr8_93283453_93283604 0.27 Ces1f
 carboxylesterase 1F
 3781
 0.19
chr8_80813537_80813711 0.26 Gab1
 growth factor receptor bound protein 2-associated protein 1
 17260
 0.18
chr10_59323965_59324136 0.26 P4ha1
 procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha 1 polypeptide
 682
 0.72
chr5_120849731_120849899 0.26 Oas1f
 2'-5' oligoadenylate synthetase 1F
 1443
 0.23
chr17_35254463_35254614 0.26 Mir8094
 microRNA 8094
 3249
 0.07
chr16_21787535_21788055 0.25 Ehhadh
 enoyl-Coenzyme A, hydratase/3-hydroxyacyl Coenzyme A dehydrogenase
 12
 0.96
chr17_25861995_25862180 0.25 Wdr90
 WD repeat domain 90
 586
 0.4
chr1_131980100_131980306 0.25 Slc45a3
 solute carrier family 45, member 3
 1239
 0.34
chr15_85658037_85658248 0.25 Lncppara
 long noncoding RNA near Ppara
 4526
 0.17
chr17_46073702_46073982 0.25 Gm36200
 predicted gene, 36200
 10424
 0.13
chr2_155674493_155674644 0.25 Trpc4ap
 transient receptor potential cation channel, subfamily C, member 4 associated protein
 1517
 0.26
chr1_91465824_91465979 0.25 Gm28381
 predicted gene 28381
 4197
 0.13
chr16_62846272_62846452 0.25 Arl13b
 ADP-ribosylation factor-like 13B
 631
 0.69
chr16_30283830_30283981 0.24 Lrrc15
 leucine rich repeat containing 15
 649
 0.64
chr15_88861401_88861700 0.24 Pim3
 proviral integration site 3
 636
 0.63
chr16_18428559_18428717 0.24 Txnrd2
 thioredoxin reductase 2
 59
 0.94
chr6_52606167_52606352 0.24 Gm44434
 predicted gene, 44434
 3014
 0.21
chr15_80679418_80679782 0.24 Fam83f
 family with sequence similarity 83, member F
 7753
 0.13
chr14_17900415_17900617 0.24 Thrb
 thyroid hormone receptor beta
 62305
 0.13
chr14_27328803_27328977 0.24 Arhgef3
 Rho guanine nucleotide exchange factor (GEF) 3
 7176
 0.23
chr1_160692487_160692638 0.24 Gm37328
 predicted gene, 37328
 34119
 0.09
chr17_43113552_43113703 0.24 E130008D07Rik
 RIKEN cDNA E130008D07 gene
 44569
 0.18
chr3_88536664_88536842 0.24 Mir1905
 microRNA 1905
 371
 0.68
chr8_109982750_109983074 0.24 Tat
 tyrosine aminotransferase
 7525
 0.12
chr13_60730621_60730876 0.23 Dapk1
 death associated protein kinase 1
 23248
 0.14
chr5_138948024_138948178 0.23 Pdgfa
 platelet derived growth factor, alpha
 46180
 0.12
chr6_145855716_145856207 0.23 Gm43909
 predicted gene, 43909
 7336
 0.17
chr7_101301283_101301902 0.23 Atg16l2
 autophagy related 16-like 2 (S. cerevisiae)
 435
 0.73
chr1_86497756_86497986 0.23 Rpl30-ps6
 ribosomal protein L30, pseudogene 6
 24212
 0.11
chr7_128460851_128461002 0.23 Tial1
 Tia1 cytotoxic granule-associated RNA binding protein-like 1
 283
 0.79
chr5_140119388_140119599 0.23 Mad1l1
 MAD1 mitotic arrest deficient 1-like 1
 4027
 0.19
chr4_115411935_115412583 0.23 Cyp4a12b
 cytochrome P450, family 4, subfamily a, polypeptide 12B
 635
 0.62
chr6_146470035_146470223 0.23 Gm15720
 predicted gene 15720
 6522
 0.21
chr4_102430791_102430956 0.23 Pde4b
 phosphodiesterase 4B, cAMP specific
 826
 0.77
chr7_51972606_51972763 0.23 Gas2
 growth arrest specific 2
 29000
 0.14
chr1_175607741_175607962 0.23 Fh1
 fumarate hydratase 1
 1204
 0.45
chr14_41109398_41109729 0.22 Mat1a
 methionine adenosyltransferase I, alpha
 4182
 0.14
chr4_45467831_45468030 0.22 Shb
 src homology 2 domain-containing transforming protein B
 14872
 0.15
chr13_99092586_99092968 0.22 2310020H05Rik
 RIKEN cDNA 2310020H05 gene
 4856
 0.18
chr2_30981618_30981782 0.22 BC005624
 cDNA sequence BC005624
 241
 0.74
chr4_131989644_131989821 0.22 Epb41
 erythrocyte membrane protein band 4.1
 1554
 0.27
chr19_14598748_14598937 0.22 Tle4
 transducin-like enhancer of split 4
 791
 0.75
chr13_119617412_119617581 0.22 Gm48265
 predicted gene, 48265
 4024
 0.15
chr7_49399643_49399820 0.22 Nav2
 neuron navigator 2
 35010
 0.18
chr2_127507226_127507383 0.21 AL731831.1
 prominin 2 (Prom2), pseudogene
 11991
 0.13
chr11_119109577_119109728 0.21 Gm11754
 predicted gene 11754
 1773
 0.27
chr12_70719191_70719367 0.21 Gm32369
 predicted gene, 32369
 37429
 0.13
chr8_106838845_106839041 0.21 Has3
 hyaluronan synthase 3
 31299
 0.13
chr11_69686428_69686593 0.21 Tnfsf13
 tumor necrosis factor (ligand) superfamily, member 13
 726
 0.29
chr7_118698775_118698967 0.21 Gde1
 glycerophosphodiester phosphodiesterase 1
 6509
 0.13
chr8_105811176_105811604 0.21 Ranbp10
 RAN binding protein 10
 15815
 0.09
chr6_119351793_119352010 0.21 Cacna2d4
 calcium channel, voltage-dependent, alpha 2/delta subunit 4
 19339
 0.17
chr2_136952741_136952943 0.21 Slx4ip
 SLX4 interacting protein
 47299
 0.13
chr15_3559431_3559670 0.21 Ghr
 growth hormone receptor
 22292
 0.23
chr3_152478706_152478877 0.21 Ak5
 adenylate kinase 5
 276
 0.91
chr13_44733163_44733323 0.21 Jarid2
 jumonji, AT rich interactive domain 2
 797
 0.73
chr2_102694561_102694718 0.21 Slc1a2
 solute carrier family 1 (glial high affinity glutamate transporter), member 2
 11717
 0.23
chr11_98863094_98863383 0.21 Wipf2
 WAS/WASL interacting protein family, member 2
 400
 0.74
chr12_76264161_76264635 0.20 Mthfd1
 methylenetetrahydrofolate dehydrogenase (NADP+ dependent), methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthase
 8918
 0.12
chr9_59542656_59542807 0.20 Tmem202
 transmembrane protein 202
 2884
 0.18
chr19_58372705_58372871 0.20 Gfra1
 glial cell line derived neurotrophic factor family receptor alpha 1
 81678
 0.09
chr8_69959520_69959671 0.20 Gatad2a
 GATA zinc finger domain containing 2A
 1191
 0.37
chr7_136894564_136895115 0.20 Mgmt
 O-6-methylguanine-DNA methyltransferase
 225
 0.95
chr15_97247773_97248330 0.19 Amigo2
 adhesion molecule with Ig like domain 2
 764
 0.48

Histogram of CRE-TSS distances for CREs targeted by :

Histogram of

Rank distribution of CRE target scores:

Histogram of target CRE score.

Distribution of target CREs across different genomic regions:

Weighted Piechart of Weighted Piechart of Weighted Piechart of

Network of associatons between targets according to the STRING database.

First level regulatory network of Trp63

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0061738 late endosomal microautophagy(GO:0061738)
0.1 0.2 GO:0060468 prevention of polyspermy(GO:0060468)
0.1 0.3 GO:0061073 ciliary body morphogenesis(GO:0061073)
0.1 0.2 GO:0006015 5-phosphoribose 1-diphosphate biosynthetic process(GO:0006015) 5-phosphoribose 1-diphosphate metabolic process(GO:0046391)
0.1 0.2 GO:1901078 negative regulation of relaxation of muscle(GO:1901078)
0.1 0.2 GO:0006068 ethanol catabolic process(GO:0006068)
0.0 0.2 GO:0002326 B cell lineage commitment(GO:0002326)
0.0 0.1 GO:0034310 primary alcohol catabolic process(GO:0034310)
0.0 0.1 GO:1903800 positive regulation of production of miRNAs involved in gene silencing by miRNA(GO:1903800)
0.0 0.1 GO:0033387 putrescine biosynthetic process from ornithine(GO:0033387)
0.0 0.3 GO:0019441 tryptophan catabolic process(GO:0006569) tryptophan catabolic process to kynurenine(GO:0019441) indole-containing compound catabolic process(GO:0042436) indolalkylamine catabolic process(GO:0046218)
0.0 0.1 GO:0030397 membrane disassembly(GO:0030397) nuclear envelope disassembly(GO:0051081)
0.0 0.2 GO:0021943 formation of radial glial scaffolds(GO:0021943)
0.0 0.2 GO:0039689 negative stranded viral RNA replication(GO:0039689) multi-organism biosynthetic process(GO:0044034)
0.0 0.2 GO:0006307 DNA dealkylation involved in DNA repair(GO:0006307)
0.0 0.1 GO:0098700 aminergic neurotransmitter loading into synaptic vesicle(GO:0015842) neurotransmitter loading into synaptic vesicle(GO:0098700)
0.0 0.3 GO:0052697 xenobiotic glucuronidation(GO:0052697)
0.0 0.1 GO:0021827 cerebral cortex tangential migration using cell-cell interactions(GO:0021823) postnatal olfactory bulb interneuron migration(GO:0021827)
0.0 0.2 GO:0009256 10-formyltetrahydrofolate metabolic process(GO:0009256)
0.0 0.1 GO:0046813 receptor-mediated virion attachment to host cell(GO:0046813)
0.0 0.1 GO:0034287 detection of carbohydrate stimulus(GO:0009730) detection of hexose stimulus(GO:0009732) detection of monosaccharide stimulus(GO:0034287) detection of glucose(GO:0051594)
0.0 0.2 GO:0002317 plasma cell differentiation(GO:0002317)
0.0 0.2 GO:0018401 peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401)
0.0 0.1 GO:0021847 ventricular zone neuroblast division(GO:0021847)
0.0 0.2 GO:0008295 spermidine biosynthetic process(GO:0008295)
0.0 0.1 GO:0035461 vitamin transmembrane transport(GO:0035461)
0.0 0.1 GO:0071895 odontoblast differentiation(GO:0071895)
0.0 0.1 GO:0006166 purine ribonucleoside salvage(GO:0006166)
0.0 0.1 GO:0002572 pro-T cell differentiation(GO:0002572)
0.0 0.1 GO:0045917 positive regulation of complement activation(GO:0045917) positive regulation of protein activation cascade(GO:2000259)
0.0 0.1 GO:0006106 fumarate metabolic process(GO:0006106)
0.0 1.1 GO:0070542 response to fatty acid(GO:0070542)
0.0 0.1 GO:2001013 epithelial cell proliferation involved in renal tubule morphogenesis(GO:2001013)
0.0 0.2 GO:0046512 diol biosynthetic process(GO:0034312) sphingosine biosynthetic process(GO:0046512)
0.0 0.1 GO:0006562 proline catabolic process(GO:0006562)
0.0 0.1 GO:0045079 negative regulation of chemokine biosynthetic process(GO:0045079)
0.0 0.1 GO:0060355 positive regulation of cell adhesion molecule production(GO:0060355)
0.0 0.1 GO:0015888 thiamine transport(GO:0015888)
0.0 0.1 GO:0030421 defecation(GO:0030421)
0.0 0.1 GO:0010046 response to mycotoxin(GO:0010046)
0.0 0.1 GO:0048290 isotype switching to IgA isotypes(GO:0048290) regulation of isotype switching to IgA isotypes(GO:0048296)
0.0 0.1 GO:0034476 U1 snRNA 3'-end processing(GO:0034473) U5 snRNA 3'-end processing(GO:0034476)
0.0 0.1 GO:0006104 succinyl-CoA metabolic process(GO:0006104)
0.0 0.2 GO:0051574 positive regulation of histone H3-K9 methylation(GO:0051574)
0.0 0.1 GO:2000048 negative regulation of cell-cell adhesion mediated by cadherin(GO:2000048)
0.0 0.1 GO:0006551 leucine metabolic process(GO:0006551)
0.0 0.1 GO:0035283 central nervous system segmentation(GO:0035283) brain segmentation(GO:0035284)
0.0 0.1 GO:0050882 voluntary musculoskeletal movement(GO:0050882)
0.0 0.1 GO:0070236 negative regulation of activation-induced cell death of T cells(GO:0070236)
0.0 0.1 GO:0006642 triglyceride mobilization(GO:0006642)
0.0 0.1 GO:0097167 circadian regulation of translation(GO:0097167)
0.0 0.1 GO:0009078 alanine metabolic process(GO:0006522) pyruvate family amino acid metabolic process(GO:0009078)
0.0 0.1 GO:1904193 cholangiocyte apoptotic process(GO:1902488) regulation of cholangiocyte apoptotic process(GO:1904192) negative regulation of cholangiocyte apoptotic process(GO:1904193)
0.0 0.1 GO:0019626 short-chain fatty acid catabolic process(GO:0019626)
0.0 0.1 GO:0070934 CRD-mediated mRNA stabilization(GO:0070934)
0.0 0.1 GO:0042866 pyruvate biosynthetic process(GO:0042866)
0.0 0.0 GO:0090259 regulation of retinal ganglion cell axon guidance(GO:0090259)
0.0 0.0 GO:0060523 prostate epithelial cord elongation(GO:0060523)
0.0 0.1 GO:0019530 taurine metabolic process(GO:0019530)
0.0 0.1 GO:0046726 positive regulation by virus of viral protein levels in host cell(GO:0046726)
0.0 0.1 GO:0061179 negative regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0061179)
0.0 0.5 GO:0019373 epoxygenase P450 pathway(GO:0019373)
0.0 0.0 GO:0055099 response to high density lipoprotein particle(GO:0055099)
0.0 0.1 GO:0060528 secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development(GO:0060528)
0.0 0.1 GO:0010944 negative regulation of transcription by competitive promoter binding(GO:0010944)
0.0 0.1 GO:0072488 ammonium transmembrane transport(GO:0072488)
0.0 0.0 GO:0046416 D-amino acid metabolic process(GO:0046416)
0.0 0.1 GO:1900364 negative regulation of mRNA polyadenylation(GO:1900364)
0.0 0.2 GO:0070050 neuron cellular homeostasis(GO:0070050)
0.0 0.1 GO:1904491 protein localization to ciliary transition zone(GO:1904491)
0.0 0.1 GO:0071985 multivesicular body sorting pathway(GO:0071985)
0.0 0.0 GO:0006573 valine metabolic process(GO:0006573)
0.0 0.1 GO:0061087 positive regulation of histone H3-K27 methylation(GO:0061087)
0.0 0.1 GO:2000015 regulation of determination of dorsal identity(GO:2000015)
0.0 0.0 GO:0097252 oligodendrocyte apoptotic process(GO:0097252)
0.0 0.1 GO:0046689 response to mercury ion(GO:0046689)
0.0 0.0 GO:0008050 female courtship behavior(GO:0008050)
0.0 0.1 GO:0001842 neural fold formation(GO:0001842)
0.0 0.0 GO:0021564 vagus nerve development(GO:0021564)
0.0 0.2 GO:0015985 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.0 0.1 GO:0003383 apical constriction(GO:0003383)
0.0 0.0 GO:0061625 fructose catabolic process(GO:0006001) fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate(GO:0061624) glycolytic process through fructose-1-phosphate(GO:0061625)
0.0 0.1 GO:0070986 left/right axis specification(GO:0070986)
0.0 0.0 GO:0070368 positive regulation of hepatocyte differentiation(GO:0070368)
0.0 0.1 GO:0032790 ribosome disassembly(GO:0032790)
0.0 0.0 GO:0006285 base-excision repair, AP site formation(GO:0006285)
0.0 0.0 GO:0015770 disaccharide transport(GO:0015766) sucrose transport(GO:0015770) oligosaccharide transport(GO:0015772)
0.0 0.0 GO:0089711 L-glutamate transmembrane transport(GO:0089711)
0.0 0.1 GO:0051013 microtubule severing(GO:0051013)
0.0 0.0 GO:0031999 negative regulation of fatty acid beta-oxidation(GO:0031999)
0.0 0.2 GO:0048490 anterograde synaptic vesicle transport(GO:0048490) synaptic vesicle cytoskeletal transport(GO:0099514) synaptic vesicle transport along microtubule(GO:0099517)
0.0 0.2 GO:0071353 cellular response to interleukin-4(GO:0071353)
0.0 0.0 GO:0006556 S-adenosylmethionine biosynthetic process(GO:0006556)
0.0 0.0 GO:0060684 epithelial-mesenchymal cell signaling(GO:0060684)
0.0 0.0 GO:0002636 positive regulation of germinal center formation(GO:0002636)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0016222 procollagen-proline 4-dioxygenase complex(GO:0016222)
0.1 0.3 GO:0043202 lysosomal lumen(GO:0043202)
0.0 0.1 GO:0005775 vacuolar lumen(GO:0005775)
0.0 0.1 GO:0060053 neurofilament cytoskeleton(GO:0060053)
0.0 0.1 GO:0031088 platelet dense granule membrane(GO:0031088)
0.0 0.2 GO:0000788 nuclear nucleosome(GO:0000788)
0.0 0.1 GO:0032021 NELF complex(GO:0032021)
0.0 0.2 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.0 0.2 GO:0042587 glycogen granule(GO:0042587)
0.0 0.1 GO:0005610 laminin-5 complex(GO:0005610)
0.0 0.1 GO:0030062 mitochondrial tricarboxylic acid cycle enzyme complex(GO:0030062)
0.0 0.1 GO:0031094 platelet dense tubular network(GO:0031094)
0.0 0.1 GO:0008622 epsilon DNA polymerase complex(GO:0008622)
0.0 0.1 GO:0097452 GAIT complex(GO:0097452)
0.0 0.1 GO:0097513 myosin II filament(GO:0097513)
0.0 0.2 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.0 0.1 GO:0045239 tricarboxylic acid cycle enzyme complex(GO:0045239)
0.0 0.3 GO:0000930 gamma-tubulin complex(GO:0000930)
0.0 0.1 GO:0045180 basal cortex(GO:0045180)
0.0 0.1 GO:0035867 alphav-beta3 integrin-IGF-1-IGF1R complex(GO:0035867)
0.0 0.0 GO:0036488 CHOP-C/EBP complex(GO:0036488)
0.0 0.0 GO:0033269 internode region of axon(GO:0033269)
0.0 0.1 GO:0031464 Cul4A-RING E3 ubiquitin ligase complex(GO:0031464)
0.0 0.1 GO:0042575 DNA polymerase complex(GO:0042575)
0.0 0.6 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 0.1 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.0 0.1 GO:0071014 post-mRNA release spliceosomal complex(GO:0071014)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.1 GO:0047760 butyrate-CoA ligase activity(GO:0047760)
0.1 0.3 GO:0070644 vitamin D response element binding(GO:0070644)
0.1 0.3 GO:0004833 tryptophan 2,3-dioxygenase activity(GO:0004833)
0.1 0.2 GO:0031686 A1 adenosine receptor binding(GO:0031686)
0.1 0.2 GO:0008184 glycogen phosphorylase activity(GO:0008184)
0.1 0.2 GO:0004165 dodecenoyl-CoA delta-isomerase activity(GO:0004165)
0.1 0.2 GO:0004024 alcohol dehydrogenase activity, zinc-dependent(GO:0004024)
0.0 0.1 GO:0048408 epidermal growth factor binding(GO:0048408)
0.0 0.2 GO:0004656 procollagen-proline 4-dioxygenase activity(GO:0004656)
0.0 0.2 GO:0004791 thioredoxin-disulfide reductase activity(GO:0004791)
0.0 0.1 GO:0070996 type 1 melanocortin receptor binding(GO:0070996)
0.0 0.2 GO:0042731 PH domain binding(GO:0042731)
0.0 0.2 GO:0047105 aminobutyraldehyde dehydrogenase activity(GO:0019145) 4-trimethylammoniobutyraldehyde dehydrogenase activity(GO:0047105)
0.0 0.2 GO:0017040 ceramidase activity(GO:0017040)
0.0 0.1 GO:0003941 L-serine ammonia-lyase activity(GO:0003941)
0.0 0.1 GO:0016899 oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor(GO:0016899)
0.0 0.3 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.0 0.1 GO:0032190 acrosin binding(GO:0032190)
0.0 0.1 GO:0005220 inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.0 0.1 GO:0004366 glycerol-3-phosphate O-acyltransferase activity(GO:0004366)
0.0 0.2 GO:0033695 oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor(GO:0033695) caffeine oxidase activity(GO:0034875)
0.0 0.3 GO:0043915 cobinamide kinase activity(GO:0008819) phytol kinase activity(GO:0010276) phenol kinase activity(GO:0018720) cyclin-dependent protein kinase activating kinase regulator activity(GO:0019914) inositol tetrakisphosphate 2-kinase activity(GO:0032942) heptose 7-phosphate kinase activity(GO:0033785) aminoglycoside phosphotransferase activity(GO:0034071) eukaryotic elongation factor-2 kinase regulator activity(GO:0042556) eukaryotic elongation factor-2 kinase activator activity(GO:0042557) LPPG:FO 2-phospho-L-lactate transferase activity(GO:0043743) cytidine kinase activity(GO:0043771) glycerate 2-kinase activity(GO:0043798) (S)-lactate 2-kinase activity(GO:0043841) phosphoserine:homoserine phosphotransferase activity(GO:0043899) L-seryl-tRNA(Sec) kinase activity(GO:0043915) phosphocholine transferase activity(GO:0044605) GTP-dependent polynucleotide kinase activity(GO:0051735) farnesol kinase activity(GO:0052668) CTP:2-trans,-6-trans-farnesol kinase activity(GO:0052669) geraniol kinase activity(GO:0052670) geranylgeraniol kinase activity(GO:0052671) CTP:geranylgeraniol kinase activity(GO:0052672) prenol kinase activity(GO:0052673) 1-phosphatidylinositol-5-kinase activity(GO:0052810) 1-phosphatidylinositol-3-phosphate 4-kinase activity(GO:0052811) phosphatidylinositol-3,4-bisphosphate 5-kinase activity(GO:0052812) inositol-3,4,6-trisphosphate 1-kinase activity(GO:0052835) inositol 5-diphosphate pentakisphosphate 5-kinase activity(GO:0052836) inositol diphosphate tetrakisphosphate kinase activity(GO:0052839)
0.0 0.3 GO:0004312 fatty acid synthase activity(GO:0004312)
0.0 0.1 GO:0046976 histone methyltransferase activity (H3-K27 specific)(GO:0046976)
0.0 0.3 GO:0019206 nucleoside kinase activity(GO:0019206)
0.0 0.1 GO:2001070 starch binding(GO:2001070)
0.0 0.1 GO:0008142 oxysterol binding(GO:0008142)
0.0 0.1 GO:0080130 L-phenylalanine:2-oxoglutarate aminotransferase activity(GO:0080130)
0.0 0.1 GO:0030984 kininogen binding(GO:0030984)
0.0 0.1 GO:0034186 apolipoprotein A-I binding(GO:0034186)
0.0 0.1 GO:0009374 biotin binding(GO:0009374)
0.0 0.0 GO:0019153 protein-disulfide reductase (glutathione) activity(GO:0019153)
0.0 0.1 GO:0008046 axon guidance receptor activity(GO:0008046)
0.0 0.1 GO:0022820 potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820)
0.0 0.1 GO:0102344 3-hydroxy-behenoyl-CoA dehydratase activity(GO:0102344) 3-hydroxy-lignoceroyl-CoA dehydratase activity(GO:0102345)
0.0 0.0 GO:0071614 linoleic acid epoxygenase activity(GO:0071614)
0.0 0.1 GO:0090409 acyl-CoA ligase activity(GO:0003996) 3-oxo-2-(2'-pentenyl)cyclopentane-1-octanoic acid CoA ligase activity(GO:0010435) 3-isopropenyl-6-oxoheptanoyl-CoA synthetase activity(GO:0018854) 2-oxo-delta3-4,5,5-trimethylcyclopentenylacetyl-CoA synthetase activity(GO:0018855) benzoyl acetate-CoA ligase activity(GO:0018856) 2,4-dichlorobenzoate-CoA ligase activity(GO:0018857) pivalate-CoA ligase activity(GO:0034783) cyclopropanecarboxylate-CoA ligase activity(GO:0034793) adipate-CoA ligase activity(GO:0034796) citronellyl-CoA ligase activity(GO:0034823) mentha-1,3-dione-CoA ligase activity(GO:0034841) thiophene-2-carboxylate-CoA ligase activity(GO:0034842) 2,4,4-trimethylpentanoate-CoA ligase activity(GO:0034865) cis-2-methyl-5-isopropylhexa-2,5-dienoate-CoA ligase activity(GO:0034942) trans-2-methyl-5-isopropylhexa-2,5-dienoate-CoA ligase activity(GO:0034943) branched-chain acyl-CoA synthetase (ADP-forming) activity(GO:0043759) aryl-CoA synthetase (ADP-forming) activity(GO:0043762) 3-hydroxypropionyl-CoA synthetase activity(GO:0043955) perillic acid:CoA ligase (ADP-forming) activity(GO:0052685) perillic acid:CoA ligase (AMP-forming) activity(GO:0052686) (3R)-3-isopropenyl-6-oxoheptanoate:CoA ligase (ADP-forming) activity(GO:0052687) (3R)-3-isopropenyl-6-oxoheptanoate:CoA ligase (AMP-forming) activity(GO:0052688) pristanate-CoA ligase activity(GO:0070251) malonyl-CoA synthetase activity(GO:0090409)
0.0 0.1 GO:0004579 dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.0 0.0 GO:0008515 sucrose:proton symporter activity(GO:0008506) sucrose transmembrane transporter activity(GO:0008515) disaccharide transmembrane transporter activity(GO:0015154) oligosaccharide transmembrane transporter activity(GO:0015157)
0.0 0.3 GO:0070330 aromatase activity(GO:0070330)
0.0 0.1 GO:0004887 thyroid hormone receptor activity(GO:0004887)
0.0 0.0 GO:0034056 estrogen response element binding(GO:0034056)
0.0 0.0 GO:0035514 DNA demethylase activity(GO:0035514)
0.0 0.0 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.0 0.5 GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374)
0.0 0.1 GO:0004383 guanylate cyclase activity(GO:0004383)
0.0 0.1 GO:0008140 cAMP response element binding protein binding(GO:0008140)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 PID P38 MK2 PATHWAY p38 signaling mediated by MAPKAP kinases
0.0 0.1 PID P38 GAMMA DELTA PATHWAY Signaling mediated by p38-gamma and p38-delta
0.0 0.2 PID SYNDECAN 3 PATHWAY Syndecan-3-mediated signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 REACTOME TRYPTOPHAN CATABOLISM Genes involved in Tryptophan catabolism
0.0 0.1 REACTOME ETHANOL OXIDATION Genes involved in Ethanol oxidation
0.0 0.3 REACTOME VITAMIN B5 PANTOTHENATE METABOLISM Genes involved in Vitamin B5 (pantothenate) metabolism
0.0 0.2 REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING Genes involved in Formation of ATP by chemiosmotic coupling
0.0 0.3 REACTOME METABOLISM OF POLYAMINES Genes involved in Metabolism of polyamines
0.0 0.2 REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.0 0.3 REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation
0.0 0.1 REACTOME GLUCURONIDATION Genes involved in Glucuronidation
0.0 0.2 REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.0 0.1 REACTOME REGULATION OF COMPLEMENT CASCADE Genes involved in Regulation of Complement cascade
0.0 0.2 REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.0 0.2 REACTOME SIGNALING BY CONSTITUTIVELY ACTIVE EGFR Genes involved in Signaling by constitutively active EGFR
0.0 0.3 REACTOME MYOGENESIS Genes involved in Myogenesis
0.0 0.1 REACTOME ACTIVATION OF RAC Genes involved in Activation of Rac