Project

ENCSR904DTN: DNase-seq of mouse liver in constant darkness

Navigation

Downloads

CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for Trp63

Z-value: 1.39

Motif logo

Transcription factors associated with Trp63

Gene Symbol	Gene ID	Gene Info
Trp63 Ensembl NCBI MGI UniProt	ENSMUSG00000022510.8	Trp63

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

Gene	Promoter	Distance	Association probability	Pearson corr. coef.	P-value	Plot
Trp63	chr16_25875334_25875496	73499	0.102754	0.95	3.6e-03	Click!
Trp63	chr16_25876965_25877159	75146	0.099620	0.89	1.8e-02	Click!
Trp63	chr16_25805292_25805462	3461	0.331388	0.88	2.0e-02	Click!
Trp63	chr16_25876261_25876542	74485	0.100867	0.88	2.0e-02	Click!
Trp63	chr16_25804778_25805017	2981	0.351663	0.77	7.1e-02	Click!

Activity of the Trp63 motif across conditions

Conditions sorted by the z-value of the Trp63 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr12_104083020_104083260	1.44	Serpina4-ps1	serine (or cysteine) peptidase inhibitor, clade A, member 4, pseudogene 1	2491	0.16
chr5_125512652_125512844	1.11	Aacs	acetoacetyl-CoA synthetase	49	0.97
chr1_88122933_88123203	1.08	Gm15372	predicted gene 15372	3708	0.08
chr7_98355230_98355493	1.01	Tsku	tsukushi, small leucine rich proteoglycan	4718	0.19
chr14_21181534_21181685	0.97	Adk	adenosine kinase	105457	0.06
chr19_40184875_40185171	0.96	Cyp2c70	cytochrome P450, family 2, subfamily c, polypeptide 70	2263	0.24
chr15_59015531_59015876	0.96	Mtss1	MTSS I-BAR domain containing 1	24893	0.16
chr8_70476439_70476616	0.87	Klhl26	kelch-like 26	378	0.72
chr7_99201987_99202161	0.79	Gm45012	predicted gene 45012	292	0.86
chr7_98355533_98355727	0.77	Tsku	tsukushi, small leucine rich proteoglycan	4449	0.2
chr15_3398924_3399075	0.71	Ghr	growth hormone receptor	72645	0.11
chr5_140112771_140112922	0.67	Mad1l1	MAD1 mitotic arrest deficient 1-like 1	2620	0.23
chr11_70501874_70502034	0.67	Tm4sf5	transmembrane 4 superfamily member 5	3290	0.09
chr18_9842900_9843072	0.67	Gm23637	predicted gene, 23637	15867	0.13
chr16_42911354_42911708	0.65	Gm19522	predicted gene, 19522	534	0.77
chr12_75566070_75566284	0.65	Gm47689	predicted gene, 47689	13688	0.18
chr4_134902978_134903198	0.64	Tmem50a	transmembrane protein 50A	11927	0.14
chr11_11845438_11845699	0.63	Ddc	dopa decarboxylase	9288	0.18
chr9_48722520_48722671	0.63	Zbtb16	zinc finger and BTB domain containing 16	113350	0.05
chr16_18071409_18071560	0.59	Dgcr6	DiGeorge syndrome critical region gene 6	2004	0.23
chr11_5530853_5531004	0.58	Xbp1	X-box binding protein 1	9005	0.13
chr19_39282659_39282846	0.57	Cyp2c29	cytochrome P450, family 2, subfamily c, polypeptide 29	4322	0.25
chr17_89646332_89646522	0.57	Gm50061	predicted gene, 50061	106099	0.08
chr6_35873017_35873173	0.57	Gm43442	predicted gene 43442	53616	0.16
chr8_104789386_104789560	0.56	Gm45782	predicted gene 45782	3645	0.12
chr5_120481198_120481714	0.53	Gm15690	predicted gene 15690	553	0.54
chr19_46056737_46057343	0.53	Pprc1	peroxisome proliferative activated receptor, gamma, coactivator-related 1	176	0.92
chr11_16781411_16781603	0.52	Egfr	epidermal growth factor receptor	29277	0.16
chr11_120816054_120816209	0.50	Fasn	fatty acid synthase	676	0.49
chr5_92585412_92585563	0.50	Fam47e	family with sequence similarity 47, member E	13931	0.15
chr11_16841273_16841607	0.49	Egfros	epidermal growth factor receptor, opposite strand	10738	0.21
chr13_41202938_41203089	0.49	Elovl2	elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 2	17149	0.11
chr10_87913477_87913628	0.49	Igf1os	insulin-like growth factor 1, opposite strand	50171	0.11
chr7_19018429_19018664	0.49	Foxa3	forkhead box A3	4992	0.08
chr3_138226457_138226622	0.48	Adh7	alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide	1512	0.29
chr10_31595125_31595561	0.47	Rnf217	ring finger protein 217	13841	0.16
chr6_95710009_95710160	0.47	Suclg2	succinate-Coenzyme A ligase, GDP-forming, beta subunit	8716	0.32
chr9_53292248_53292436	0.47	Exph5	exophilin 5	9328	0.19
chr6_100096782_100096939	0.47	2010109P13Rik	RIKEN cDNA 2010109P13 gene	46954	0.15
chr14_64690169_64690374	0.46	Kif13b	kinesin family member 13B	37669	0.15
chr11_68851235_68851391	0.46	Ndel1	nudE neurodevelopment protein 1 like 1	1728	0.27
chr6_85868321_85868637	0.44	Nat8f2	N-acetyltransferase 8 (GCN5-related) family member 2	679	0.48
chr11_5916279_5916587	0.43	Gm11967	predicted gene 11967	1118	0.3
chr15_89077796_89078211	0.43	Trabd	TraB domain containing	1879	0.16
chr2_134550332_134550521	0.42	Hao1	hydroxyacid oxidase 1, liver	3881	0.35
chr6_149098639_149098790	0.42	Dennd5b	DENN/MADD domain containing 5B	2824	0.16
chr2_24901182_24901348	0.42	Gm37139	predicted gene, 37139	7399	0.1
chr6_90568851_90569300	0.41	Aldh1l1	aldehyde dehydrogenase 1 family, member L1	1369	0.35
chr12_81167975_81168146	0.41	Mir3067	microRNA 3067	1909	0.38
chr4_45852505_45852662	0.41	Stra6l	STRA6-like	3586	0.2
chr6_82647878_82648248	0.40	Pole4	polymerase (DNA-directed), epsilon 4 (p12 subunit)	4455	0.23
chr1_59157668_59157869	0.40	Mpp4	membrane protein, palmitoylated 4 (MAGUK p55 subfamily member 4)	893	0.43
chr1_169165587_169165766	0.40	Mir6354	microRNA 6354	146587	0.04
chr1_171168499_171168673	0.40	Mpz	myelin protein zero	8883	0.09
chr8_109998736_109999105	0.40	Tat	tyrosine aminotransferase	8414	0.12
chr2_158570467_158570618	0.39	Arhgap40	Rho GTPase activating protein 40	28805	0.1
chr1_71723212_71723548	0.39	Gm5256	predicted gene 5256	8456	0.19
chr4_95625117_95625268	0.39	Fggy	FGGY carbohydrate kinase domain containing	1636	0.46
chr14_21256205_21256412	0.39	Adk	adenosine kinase	61817	0.13
chr9_61809239_61809390	0.39	Gm19208	predicted gene, 19208	42390	0.15
chr7_136457949_136458342	0.38	Gm36849	predicted gene, 36849	104781	0.07
chr14_55147433_55147865	0.38	Gm23596	predicted gene, 23596	13959	0.09
chr2_26593869_26594069	0.38	Egfl7	EGF-like domain 7	1822	0.16
chr1_151131178_151131360	0.38	Gm8941	predicted gene 8941	5238	0.13
chr9_57059997_57060182	0.37	Ptpn9	protein tyrosine phosphatase, non-receptor type 9	651	0.62
chrX_60504109_60504260	0.37	Gm7073	predicted gene 7073	35065	0.14
chr7_121652771_121652941	0.37	Usp31	ubiquitin specific peptidase 31	13959	0.18
chr11_16589151_16589356	0.37	Gm12663	predicted gene 12663	46813	0.12
chrX_161717217_161717797	0.37	Rai2	retinoic acid induced 2	120	0.98
chr3_95882847_95883034	0.36	Ciart	circadian associated repressor of transcription	689	0.44
chr1_136625692_136626183	0.36	Zfp281	zinc finger protein 281	1036	0.34
chr15_10632975_10633126	0.36	Gm10389	predicted gene 10389	32713	0.14
chr5_125478134_125478423	0.36	Gm27551	predicted gene, 27551	1099	0.36
chr9_40804280_40804486	0.36	Hspa8	heat shock protein 8	101	0.66
chr5_114155622_114155805	0.35	Acacb	acetyl-Coenzyme A carboxylase beta	9178	0.12
chr2_160340207_160340432	0.35	Gm826	predicted gene 826	6157	0.26
chr6_149344317_149344633	0.35	Gm15782	predicted gene 15782	9351	0.14
chr9_115307686_115307849	0.35	Stt3b	STT3, subunit of the oligosaccharyltransferase complex, homolog B (S. cerevisiae)	2654	0.24
chr8_85500511_85501282	0.34	Gpt2	glutamic pyruvate transaminase (alanine aminotransferase) 2	8287	0.17
chr13_111895157_111895352	0.34	Gm9025	predicted gene 9025	11077	0.15
chr18_74301601_74301911	0.34	Gm14328	predicted gene 14328	2175	0.26
chr2_59160190_59160538	0.34	Ccdc148	coiled-coil domain containing 148	170	0.8
chr10_37139807_37140183	0.34	5930403N24Rik	RIKEN cDNA 5930403N24 gene	81	0.95
chr12_70198492_70198710	0.33	Pygl	liver glycogen phosphorylase	760	0.59
chr6_58733664_58733815	0.33	Gm43899	predicted gene, 43899	48198	0.13
chr6_108426569_108426787	0.33	Itpr1	inositol 1,4,5-trisphosphate receptor 1	8801	0.22
chr11_6528187_6528435	0.33	Snora9	small nucleolar RNA, H/ACA box 9	146	0.77
chr15_68363065_68363728	0.33	Gm20732	predicted gene 20732	220	0.9
chr11_79878516_79878681	0.33	9130204K15Rik	RIKEN cDNA 9130204K15 gene	6204	0.15
chrX_60400421_60400586	0.33	Atp11c	ATPase, class VI, type 11C	3478	0.24
chr2_31514792_31514964	0.32	Ass1	argininosuccinate synthetase 1	3612	0.21
chr13_73767240_73767553	0.32	Slc12a7	solute carrier family 12, member 7	3657	0.21
chr12_16584004_16584353	0.32	Lpin1	lipin 1	5542	0.26
chr4_148590620_148590972	0.32	Srm	spermidine synthase	707	0.49
chr6_118478873_118479106	0.32	Zfp9	zinc finger protein 9	331	0.85
chr4_10943152_10943325	0.32	Rps11-ps3	ribosomal protein S11, pseudogene 3	3370	0.23
chr4_53073780_53074212	0.32	Abca1	ATP-binding cassette, sub-family A (ABC1), member 1	33070	0.15
chr11_115418711_115418869	0.32	Atp5h	ATP synthase, H+ transporting, mitochondrial F0 complex, subunit D	49	0.92
chr1_194360305_194360456	0.31	4930503O07Rik	RIKEN cDNA 4930503O07 gene	137621	0.05
chr17_5232385_5232541	0.31	Gm15599	predicted gene 15599	120353	0.05
chr5_99247519_99247696	0.31	Rasgef1b	RasGEF domain family, member 1B	4367	0.26
chr8_24575832_24575983	0.31	Ido2	indoleamine 2,3-dioxygenase 2	426	0.82
chr19_55110942_55111169	0.30	Gpam	glycerol-3-phosphate acyltransferase, mitochondrial	7964	0.2
chr12_74320624_74320791	0.30	Gm34552	predicted gene, 34552	3545	0.18
chr4_14805319_14805470	0.30	Lrrc69	leucine rich repeat containing 69	9334	0.19
chr9_69226678_69226839	0.30	Rora	RAR-related orphan receptor alpha	31217	0.22
chr12_87393286_87393480	0.30	Gm48873	predicted gene, 48873	1061	0.3
chr4_119550388_119550568	0.30	Gm12959	predicted gene 12959	3580	0.12
chr7_141092673_141092858	0.30	Sigirr	single immunoglobulin and toll-interleukin 1 receptor (TIR) domain	985	0.3
chr12_80324041_80324208	0.30	Dcaf5	DDB1 and CUL4 associated factor 5	52568	0.08
chr17_34853353_34853526	0.30	Nelfe	negative elongation factor complex member E, Rdbp	497	0.46
chr5_112276946_112277327	0.30	Tpst2	protein-tyrosine sulfotransferase 2	429	0.74
chr8_127111900_127112059	0.30	Pard3	par-3 family cell polarity regulator	38739	0.16
chr5_122455478_122455753	0.30	Anapc7	anaphase promoting complex subunit 7	14240	0.09
chr12_8811934_8812098	0.29	Sdc1	syndecan 1	40213	0.13
chr1_130664035_130664240	0.29	C4bp	complement component 4 binding protein	2505	0.18
chr1_191225182_191225346	0.29	D730003I15Rik	RIKEN cDNA D730003I15 gene	790	0.54
chr12_28804906_28805226	0.29	Gm48905	predicted gene, 48905	5072	0.18
chr13_75844352_75844786	0.29	Glrx	glutaredoxin	4493	0.17
chr17_45957936_45958127	0.28	Gm49805	predicted gene, 49805	3828	0.22
chr15_78947569_78947720	0.28	Triobp	TRIO and F-actin binding protein	80	0.93
chr5_124233026_124233422	0.28	Pitpnm2os1	phosphatidylinositol transfer protein, membrane-associated 2, opposite strand 1	3499	0.14
chr15_99042750_99042942	0.28	Prph	peripherin	12328	0.08
chr14_118038826_118039199	0.28	Dct	dopachrome tautomerase	4117	0.23
chr2_91930123_91930286	0.28	Mdk	midkine	1484	0.25
chr12_77056757_77057146	0.28	Gm35189	predicted gene, 35189	14750	0.21
chr10_80433536_80433845	0.28	Tcf3	transcription factor 3	43	0.94
chr1_163150756_163150961	0.28	Gm22434	predicted gene, 22434	32631	0.15
chr8_111693865_111694016	0.28	Ctrb1	chymotrypsinogen B1	2930	0.21
chr12_76369660_76370048	0.28	Zbtb25	zinc finger and BTB domain containing 25	252	0.62
chr14_51932437_51932626	0.28	Gm49076	predicted gene, 49076	2871	0.12
chr5_138776683_138776881	0.27	Fam20c	family with sequence similarity 20, member C	9718	0.19
chr1_76911315_76911480	0.27	Gm816	predicted gene 816	116395	0.07
chr17_35814760_35815402	0.27	Ier3	immediate early response 3	6603	0.07
chr19_55548698_55548991	0.27	Vti1a	vesicle transport through interaction with t-SNAREs 1A	167830	0.03
chr9_30855695_30855884	0.27	Adamts15	a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 15	53868	0.12
chr8_93283453_93283604	0.27	Ces1f	carboxylesterase 1F	3781	0.19
chr8_80813537_80813711	0.26	Gab1	growth factor receptor bound protein 2-associated protein 1	17260	0.18
chr10_59323965_59324136	0.26	P4ha1	procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha 1 polypeptide	682	0.72
chr5_120849731_120849899	0.26	Oas1f	2'-5' oligoadenylate synthetase 1F	1443	0.23
chr17_35254463_35254614	0.26	Mir8094	microRNA 8094	3249	0.07
chr16_21787535_21788055	0.25	Ehhadh	enoyl-Coenzyme A, hydratase/3-hydroxyacyl Coenzyme A dehydrogenase	12	0.96
chr17_25861995_25862180	0.25	Wdr90	WD repeat domain 90	586	0.4
chr1_131980100_131980306	0.25	Slc45a3	solute carrier family 45, member 3	1239	0.34
chr15_85658037_85658248	0.25	Lncppara	long noncoding RNA near Ppara	4526	0.17
chr17_46073702_46073982	0.25	Gm36200	predicted gene, 36200	10424	0.13
chr2_155674493_155674644	0.25	Trpc4ap	transient receptor potential cation channel, subfamily C, member 4 associated protein	1517	0.26
chr1_91465824_91465979	0.25	Gm28381	predicted gene 28381	4197	0.13
chr16_62846272_62846452	0.25	Arl13b	ADP-ribosylation factor-like 13B	631	0.69
chr16_30283830_30283981	0.24	Lrrc15	leucine rich repeat containing 15	649	0.64
chr15_88861401_88861700	0.24	Pim3	proviral integration site 3	636	0.63
chr16_18428559_18428717	0.24	Txnrd2	thioredoxin reductase 2	59	0.94
chr6_52606167_52606352	0.24	Gm44434	predicted gene, 44434	3014	0.21
chr15_80679418_80679782	0.24	Fam83f	family with sequence similarity 83, member F	7753	0.13
chr14_17900415_17900617	0.24	Thrb	thyroid hormone receptor beta	62305	0.13
chr14_27328803_27328977	0.24	Arhgef3	Rho guanine nucleotide exchange factor (GEF) 3	7176	0.23
chr1_160692487_160692638	0.24	Gm37328	predicted gene, 37328	34119	0.09
chr17_43113552_43113703	0.24	E130008D07Rik	RIKEN cDNA E130008D07 gene	44569	0.18
chr3_88536664_88536842	0.24	Mir1905	microRNA 1905	371	0.68
chr8_109982750_109983074	0.24	Tat	tyrosine aminotransferase	7525	0.12
chr13_60730621_60730876	0.23	Dapk1	death associated protein kinase 1	23248	0.14
chr5_138948024_138948178	0.23	Pdgfa	platelet derived growth factor, alpha	46180	0.12
chr6_145855716_145856207	0.23	Gm43909	predicted gene, 43909	7336	0.17
chr7_101301283_101301902	0.23	Atg16l2	autophagy related 16-like 2 (S. cerevisiae)	435	0.73
chr1_86497756_86497986	0.23	Rpl30-ps6	ribosomal protein L30, pseudogene 6	24212	0.11
chr7_128460851_128461002	0.23	Tial1	Tia1 cytotoxic granule-associated RNA binding protein-like 1	283	0.79
chr5_140119388_140119599	0.23	Mad1l1	MAD1 mitotic arrest deficient 1-like 1	4027	0.19
chr4_115411935_115412583	0.23	Cyp4a12b	cytochrome P450, family 4, subfamily a, polypeptide 12B	635	0.62
chr6_146470035_146470223	0.23	Gm15720	predicted gene 15720	6522	0.21
chr4_102430791_102430956	0.23	Pde4b	phosphodiesterase 4B, cAMP specific	826	0.77
chr7_51972606_51972763	0.23	Gas2	growth arrest specific 2	29000	0.14
chr1_175607741_175607962	0.23	Fh1	fumarate hydratase 1	1204	0.45
chr14_41109398_41109729	0.22	Mat1a	methionine adenosyltransferase I, alpha	4182	0.14
chr4_45467831_45468030	0.22	Shb	src homology 2 domain-containing transforming protein B	14872	0.15
chr13_99092586_99092968	0.22	2310020H05Rik	RIKEN cDNA 2310020H05 gene	4856	0.18
chr2_30981618_30981782	0.22	BC005624	cDNA sequence BC005624	241	0.74
chr4_131989644_131989821	0.22	Epb41	erythrocyte membrane protein band 4.1	1554	0.27
chr19_14598748_14598937	0.22	Tle4	transducin-like enhancer of split 4	791	0.75
chr13_119617412_119617581	0.22	Gm48265	predicted gene, 48265	4024	0.15
chr7_49399643_49399820	0.22	Nav2	neuron navigator 2	35010	0.18
chr2_127507226_127507383	0.21	AL731831.1	prominin 2 (Prom2), pseudogene	11991	0.13
chr11_119109577_119109728	0.21	Gm11754	predicted gene 11754	1773	0.27
chr12_70719191_70719367	0.21	Gm32369	predicted gene, 32369	37429	0.13
chr8_106838845_106839041	0.21	Has3	hyaluronan synthase 3	31299	0.13
chr11_69686428_69686593	0.21	Tnfsf13	tumor necrosis factor (ligand) superfamily, member 13	726	0.29
chr7_118698775_118698967	0.21	Gde1	glycerophosphodiester phosphodiesterase 1	6509	0.13
chr8_105811176_105811604	0.21	Ranbp10	RAN binding protein 10	15815	0.09
chr6_119351793_119352010	0.21	Cacna2d4	calcium channel, voltage-dependent, alpha 2/delta subunit 4	19339	0.17
chr2_136952741_136952943	0.21	Slx4ip	SLX4 interacting protein	47299	0.13
chr15_3559431_3559670	0.21	Ghr	growth hormone receptor	22292	0.23
chr3_152478706_152478877	0.21	Ak5	adenylate kinase 5	276	0.91
chr13_44733163_44733323	0.21	Jarid2	jumonji, AT rich interactive domain 2	797	0.73
chr2_102694561_102694718	0.21	Slc1a2	solute carrier family 1 (glial high affinity glutamate transporter), member 2	11717	0.23
chr11_98863094_98863383	0.21	Wipf2	WAS/WASL interacting protein family, member 2	400	0.74
chr12_76264161_76264635	0.20	Mthfd1	methylenetetrahydrofolate dehydrogenase (NADP+ dependent), methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthase	8918	0.12
chr9_59542656_59542807	0.20	Tmem202	transmembrane protein 202	2884	0.18
chr19_58372705_58372871	0.20	Gfra1	glial cell line derived neurotrophic factor family receptor alpha 1	81678	0.09
chr8_69959520_69959671	0.20	Gatad2a	GATA zinc finger domain containing 2A	1191	0.37
chr7_136894564_136895115	0.20	Mgmt	O-6-methylguanine-DNA methyltransferase	225	0.95
chr15_97247773_97248330	0.19	Amigo2	adhesion molecule with Ig like domain 2	764	0.48

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of Trp63

View svg image
View png image

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.2	GO:0061738	late endosomal microautophagy(GO:0061738)
0.1	0.2	GO:0060468	prevention of polyspermy(GO:0060468)
0.1	0.3	GO:0061073	ciliary body morphogenesis(GO:0061073)
0.1	0.2	GO:0006015	5-phosphoribose 1-diphosphate biosynthetic process(GO:0006015) 5-phosphoribose 1-diphosphate metabolic process(GO:0046391)
0.1	0.2	GO:1901078	negative regulation of relaxation of muscle(GO:1901078)
0.1	0.2	GO:0006068	ethanol catabolic process(GO:0006068)
0.0	0.2	GO:0002326	B cell lineage commitment(GO:0002326)
0.0	0.1	GO:0034310	primary alcohol catabolic process(GO:0034310)
0.0	0.1	GO:1903800	positive regulation of production of miRNAs involved in gene silencing by miRNA(GO:1903800)
0.0	0.1	GO:0033387	putrescine biosynthetic process from ornithine(GO:0033387)
0.0	0.3	GO:0019441	tryptophan catabolic process(GO:0006569) tryptophan catabolic process to kynurenine(GO:0019441) indole-containing compound catabolic process(GO:0042436) indolalkylamine catabolic process(GO:0046218)
0.0	0.1	GO:0030397	membrane disassembly(GO:0030397) nuclear envelope disassembly(GO:0051081)
0.0	0.2	GO:0021943	formation of radial glial scaffolds(GO:0021943)
0.0	0.2	GO:0039689	negative stranded viral RNA replication(GO:0039689) multi-organism biosynthetic process(GO:0044034)
0.0	0.2	GO:0006307	DNA dealkylation involved in DNA repair(GO:0006307)
0.0	0.1	GO:0098700	aminergic neurotransmitter loading into synaptic vesicle(GO:0015842) neurotransmitter loading into synaptic vesicle(GO:0098700)
0.0	0.3	GO:0052697	xenobiotic glucuronidation(GO:0052697)
0.0	0.1	GO:0021827	cerebral cortex tangential migration using cell-cell interactions(GO:0021823) postnatal olfactory bulb interneuron migration(GO:0021827)
0.0	0.2	GO:0009256	10-formyltetrahydrofolate metabolic process(GO:0009256)
0.0	0.1	GO:0046813	receptor-mediated virion attachment to host cell(GO:0046813)
0.0	0.1	GO:0034287	detection of carbohydrate stimulus(GO:0009730) detection of hexose stimulus(GO:0009732) detection of monosaccharide stimulus(GO:0034287) detection of glucose(GO:0051594)
0.0	0.2	GO:0002317	plasma cell differentiation(GO:0002317)
0.0	0.2	GO:0018401	peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401)
0.0	0.1	GO:0021847	ventricular zone neuroblast division(GO:0021847)
0.0	0.2	GO:0008295	spermidine biosynthetic process(GO:0008295)
0.0	0.1	GO:0035461	vitamin transmembrane transport(GO:0035461)
0.0	0.1	GO:0071895	odontoblast differentiation(GO:0071895)
0.0	0.1	GO:0006166	purine ribonucleoside salvage(GO:0006166)
0.0	0.1	GO:0002572	pro-T cell differentiation(GO:0002572)
0.0	0.1	GO:0045917	positive regulation of complement activation(GO:0045917) positive regulation of protein activation cascade(GO:2000259)
0.0	0.1	GO:0006106	fumarate metabolic process(GO:0006106)
0.0	1.1	GO:0070542	response to fatty acid(GO:0070542)
0.0	0.1	GO:2001013	epithelial cell proliferation involved in renal tubule morphogenesis(GO:2001013)
0.0	0.2	GO:0046512	diol biosynthetic process(GO:0034312) sphingosine biosynthetic process(GO:0046512)
0.0	0.1	GO:0006562	proline catabolic process(GO:0006562)
0.0	0.1	GO:0045079	negative regulation of chemokine biosynthetic process(GO:0045079)
0.0	0.1	GO:0060355	positive regulation of cell adhesion molecule production(GO:0060355)
0.0	0.1	GO:0015888	thiamine transport(GO:0015888)
0.0	0.1	GO:0030421	defecation(GO:0030421)
0.0	0.1	GO:0010046	response to mycotoxin(GO:0010046)
0.0	0.1	GO:0048290	isotype switching to IgA isotypes(GO:0048290) regulation of isotype switching to IgA isotypes(GO:0048296)
0.0	0.1	GO:0034476	U1 snRNA 3'-end processing(GO:0034473) U5 snRNA 3'-end processing(GO:0034476)
0.0	0.1	GO:0006104	succinyl-CoA metabolic process(GO:0006104)
0.0	0.2	GO:0051574	positive regulation of histone H3-K9 methylation(GO:0051574)
0.0	0.1	GO:2000048	negative regulation of cell-cell adhesion mediated by cadherin(GO:2000048)
0.0	0.1	GO:0006551	leucine metabolic process(GO:0006551)
0.0	0.1	GO:0035283	central nervous system segmentation(GO:0035283) brain segmentation(GO:0035284)
0.0	0.1	GO:0050882	voluntary musculoskeletal movement(GO:0050882)
0.0	0.1	GO:0070236	negative regulation of activation-induced cell death of T cells(GO:0070236)
0.0	0.1	GO:0006642	triglyceride mobilization(GO:0006642)
0.0	0.1	GO:0097167	circadian regulation of translation(GO:0097167)
0.0	0.1	GO:0009078	alanine metabolic process(GO:0006522) pyruvate family amino acid metabolic process(GO:0009078)
0.0	0.1	GO:1904193	cholangiocyte apoptotic process(GO:1902488) regulation of cholangiocyte apoptotic process(GO:1904192) negative regulation of cholangiocyte apoptotic process(GO:1904193)
0.0	0.1	GO:0019626	short-chain fatty acid catabolic process(GO:0019626)
0.0	0.1	GO:0070934	CRD-mediated mRNA stabilization(GO:0070934)
0.0	0.1	GO:0042866	pyruvate biosynthetic process(GO:0042866)
0.0	0.0	GO:0090259	regulation of retinal ganglion cell axon guidance(GO:0090259)
0.0	0.0	GO:0060523	prostate epithelial cord elongation(GO:0060523)
0.0	0.1	GO:0019530	taurine metabolic process(GO:0019530)
0.0	0.1	GO:0046726	positive regulation by virus of viral protein levels in host cell(GO:0046726)
0.0	0.1	GO:0061179	negative regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0061179)
0.0	0.5	GO:0019373	epoxygenase P450 pathway(GO:0019373)
0.0	0.0	GO:0055099	response to high density lipoprotein particle(GO:0055099)
0.0	0.1	GO:0060528	secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development(GO:0060528)
0.0	0.1	GO:0010944	negative regulation of transcription by competitive promoter binding(GO:0010944)
0.0	0.1	GO:0072488	ammonium transmembrane transport(GO:0072488)
0.0	0.0	GO:0046416	D-amino acid metabolic process(GO:0046416)
0.0	0.1	GO:1900364	negative regulation of mRNA polyadenylation(GO:1900364)
0.0	0.2	GO:0070050	neuron cellular homeostasis(GO:0070050)
0.0	0.1	GO:1904491	protein localization to ciliary transition zone(GO:1904491)
0.0	0.1	GO:0071985	multivesicular body sorting pathway(GO:0071985)
0.0	0.0	GO:0006573	valine metabolic process(GO:0006573)
0.0	0.1	GO:0061087	positive regulation of histone H3-K27 methylation(GO:0061087)
0.0	0.1	GO:2000015	regulation of determination of dorsal identity(GO:2000015)
0.0	0.0	GO:0097252	oligodendrocyte apoptotic process(GO:0097252)
0.0	0.1	GO:0046689	response to mercury ion(GO:0046689)
0.0	0.0	GO:0008050	female courtship behavior(GO:0008050)
0.0	0.1	GO:0001842	neural fold formation(GO:0001842)
0.0	0.0	GO:0021564	vagus nerve development(GO:0021564)
0.0	0.2	GO:0015985	energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.0	0.1	GO:0003383	apical constriction(GO:0003383)
0.0	0.0	GO:0061625	fructose catabolic process(GO:0006001) fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate(GO:0061624) glycolytic process through fructose-1-phosphate(GO:0061625)
0.0	0.1	GO:0070986	left/right axis specification(GO:0070986)
0.0	0.0	GO:0070368	positive regulation of hepatocyte differentiation(GO:0070368)
0.0	0.1	GO:0032790	ribosome disassembly(GO:0032790)
0.0	0.0	GO:0006285	base-excision repair, AP site formation(GO:0006285)
0.0	0.0	GO:0015770	disaccharide transport(GO:0015766) sucrose transport(GO:0015770) oligosaccharide transport(GO:0015772)
0.0	0.0	GO:0089711	L-glutamate transmembrane transport(GO:0089711)
0.0	0.1	GO:0051013	microtubule severing(GO:0051013)
0.0	0.0	GO:0031999	negative regulation of fatty acid beta-oxidation(GO:0031999)
0.0	0.2	GO:0048490	anterograde synaptic vesicle transport(GO:0048490) synaptic vesicle cytoskeletal transport(GO:0099514) synaptic vesicle transport along microtubule(GO:0099517)
0.0	0.2	GO:0071353	cellular response to interleukin-4(GO:0071353)
0.0	0.0	GO:0006556	S-adenosylmethionine biosynthetic process(GO:0006556)
0.0	0.0	GO:0060684	epithelial-mesenchymal cell signaling(GO:0060684)
0.0	0.0	GO:0002636	positive regulation of germinal center formation(GO:0002636)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.2	GO:0016222	procollagen-proline 4-dioxygenase complex(GO:0016222)
0.1	0.3	GO:0043202	lysosomal lumen(GO:0043202)
0.0	0.1	GO:0005775	vacuolar lumen(GO:0005775)
0.0	0.1	GO:0060053	neurofilament cytoskeleton(GO:0060053)
0.0	0.1	GO:0031088	platelet dense granule membrane(GO:0031088)
0.0	0.2	GO:0000788	nuclear nucleosome(GO:0000788)
0.0	0.1	GO:0032021	NELF complex(GO:0032021)
0.0	0.2	GO:0000276	mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.0	0.2	GO:0042587	glycogen granule(GO:0042587)
0.0	0.1	GO:0005610	laminin-5 complex(GO:0005610)
0.0	0.1	GO:0030062	mitochondrial tricarboxylic acid cycle enzyme complex(GO:0030062)
0.0	0.1	GO:0031094	platelet dense tubular network(GO:0031094)
0.0	0.1	GO:0008622	epsilon DNA polymerase complex(GO:0008622)
0.0	0.1	GO:0097452	GAIT complex(GO:0097452)
0.0	0.1	GO:0097513	myosin II filament(GO:0097513)
0.0	0.2	GO:0035098	ESC/E(Z) complex(GO:0035098)
0.0	0.1	GO:0045239	tricarboxylic acid cycle enzyme complex(GO:0045239)
0.0	0.3	GO:0000930	gamma-tubulin complex(GO:0000930)
0.0	0.1	GO:0045180	basal cortex(GO:0045180)
0.0	0.1	GO:0035867	alphav-beta3 integrin-IGF-1-IGF1R complex(GO:0035867)
0.0	0.0	GO:0036488	CHOP-C/EBP complex(GO:0036488)
0.0	0.0	GO:0033269	internode region of axon(GO:0033269)
0.0	0.1	GO:0031464	Cul4A-RING E3 ubiquitin ligase complex(GO:0031464)
0.0	0.1	GO:0042575	DNA polymerase complex(GO:0042575)
0.0	0.6	GO:0031463	Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0	0.1	GO:0008074	guanylate cyclase complex, soluble(GO:0008074)
0.0	0.1	GO:0071014	post-mRNA release spliceosomal complex(GO:0071014)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	1.1	GO:0047760	butyrate-CoA ligase activity(GO:0047760)
0.1	0.3	GO:0070644	vitamin D response element binding(GO:0070644)
0.1	0.3	GO:0004833	tryptophan 2,3-dioxygenase activity(GO:0004833)
0.1	0.2	GO:0031686	A1 adenosine receptor binding(GO:0031686)
0.1	0.2	GO:0008184	glycogen phosphorylase activity(GO:0008184)
0.1	0.2	GO:0004165	dodecenoyl-CoA delta-isomerase activity(GO:0004165)
0.1	0.2	GO:0004024	alcohol dehydrogenase activity, zinc-dependent(GO:0004024)
0.0	0.1	GO:0048408	epidermal growth factor binding(GO:0048408)
0.0	0.2	GO:0004656	procollagen-proline 4-dioxygenase activity(GO:0004656)
0.0	0.2	GO:0004791	thioredoxin-disulfide reductase activity(GO:0004791)
0.0	0.1	GO:0070996	type 1 melanocortin receptor binding(GO:0070996)
0.0	0.2	GO:0042731	PH domain binding(GO:0042731)
0.0	0.2	GO:0047105	aminobutyraldehyde dehydrogenase activity(GO:0019145) 4-trimethylammoniobutyraldehyde dehydrogenase activity(GO:0047105)
0.0	0.2	GO:0017040	ceramidase activity(GO:0017040)
0.0	0.1	GO:0003941	L-serine ammonia-lyase activity(GO:0003941)
0.0	0.1	GO:0016899	oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor(GO:0016899)
0.0	0.3	GO:0046933	proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.0	0.1	GO:0032190	acrosin binding(GO:0032190)
0.0	0.1	GO:0005220	inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.0	0.1	GO:0004366	glycerol-3-phosphate O-acyltransferase activity(GO:0004366)
0.0	0.2	GO:0033695	oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor(GO:0033695) caffeine oxidase activity(GO:0034875)
0.0	0.3	GO:0043915	cobinamide kinase activity(GO:0008819) phytol kinase activity(GO:0010276) phenol kinase activity(GO:0018720) cyclin-dependent protein kinase activating kinase regulator activity(GO:0019914) inositol tetrakisphosphate 2-kinase activity(GO:0032942) heptose 7-phosphate kinase activity(GO:0033785) aminoglycoside phosphotransferase activity(GO:0034071) eukaryotic elongation factor-2 kinase regulator activity(GO:0042556) eukaryotic elongation factor-2 kinase activator activity(GO:0042557) LPPG:FO 2-phospho-L-lactate transferase activity(GO:0043743) cytidine kinase activity(GO:0043771) glycerate 2-kinase activity(GO:0043798) (S)-lactate 2-kinase activity(GO:0043841) phosphoserine:homoserine phosphotransferase activity(GO:0043899) L-seryl-tRNA(Sec) kinase activity(GO:0043915) phosphocholine transferase activity(GO:0044605) GTP-dependent polynucleotide kinase activity(GO:0051735) farnesol kinase activity(GO:0052668) CTP:2-trans,-6-trans-farnesol kinase activity(GO:0052669) geraniol kinase activity(GO:0052670) geranylgeraniol kinase activity(GO:0052671) CTP:geranylgeraniol kinase activity(GO:0052672) prenol kinase activity(GO:0052673) 1-phosphatidylinositol-5-kinase activity(GO:0052810) 1-phosphatidylinositol-3-phosphate 4-kinase activity(GO:0052811) phosphatidylinositol-3,4-bisphosphate 5-kinase activity(GO:0052812) inositol-3,4,6-trisphosphate 1-kinase activity(GO:0052835) inositol 5-diphosphate pentakisphosphate 5-kinase activity(GO:0052836) inositol diphosphate tetrakisphosphate kinase activity(GO:0052839)
0.0	0.3	GO:0004312	fatty acid synthase activity(GO:0004312)
0.0	0.1	GO:0046976	histone methyltransferase activity (H3-K27 specific)(GO:0046976)
0.0	0.3	GO:0019206	nucleoside kinase activity(GO:0019206)
0.0	0.1	GO:2001070	starch binding(GO:2001070)
0.0	0.1	GO:0008142	oxysterol binding(GO:0008142)
0.0	0.1	GO:0080130	L-phenylalanine:2-oxoglutarate aminotransferase activity(GO:0080130)
0.0	0.1	GO:0030984	kininogen binding(GO:0030984)
0.0	0.1	GO:0034186	apolipoprotein A-I binding(GO:0034186)
0.0	0.1	GO:0009374	biotin binding(GO:0009374)
0.0	0.0	GO:0019153	protein-disulfide reductase (glutathione) activity(GO:0019153)
0.0	0.1	GO:0008046	axon guidance receptor activity(GO:0008046)
0.0	0.1	GO:0022820	potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820)
0.0	0.1	GO:0102344	3-hydroxy-behenoyl-CoA dehydratase activity(GO:0102344) 3-hydroxy-lignoceroyl-CoA dehydratase activity(GO:0102345)
0.0	0.0	GO:0071614	linoleic acid epoxygenase activity(GO:0071614)
0.0	0.1	GO:0090409	acyl-CoA ligase activity(GO:0003996) 3-oxo-2-(2'-pentenyl)cyclopentane-1-octanoic acid CoA ligase activity(GO:0010435) 3-isopropenyl-6-oxoheptanoyl-CoA synthetase activity(GO:0018854) 2-oxo-delta3-4,5,5-trimethylcyclopentenylacetyl-CoA synthetase activity(GO:0018855) benzoyl acetate-CoA ligase activity(GO:0018856) 2,4-dichlorobenzoate-CoA ligase activity(GO:0018857) pivalate-CoA ligase activity(GO:0034783) cyclopropanecarboxylate-CoA ligase activity(GO:0034793) adipate-CoA ligase activity(GO:0034796) citronellyl-CoA ligase activity(GO:0034823) mentha-1,3-dione-CoA ligase activity(GO:0034841) thiophene-2-carboxylate-CoA ligase activity(GO:0034842) 2,4,4-trimethylpentanoate-CoA ligase activity(GO:0034865) cis-2-methyl-5-isopropylhexa-2,5-dienoate-CoA ligase activity(GO:0034942) trans-2-methyl-5-isopropylhexa-2,5-dienoate-CoA ligase activity(GO:0034943) branched-chain acyl-CoA synthetase (ADP-forming) activity(GO:0043759) aryl-CoA synthetase (ADP-forming) activity(GO:0043762) 3-hydroxypropionyl-CoA synthetase activity(GO:0043955) perillic acid:CoA ligase (ADP-forming) activity(GO:0052685) perillic acid:CoA ligase (AMP-forming) activity(GO:0052686) (3R)-3-isopropenyl-6-oxoheptanoate:CoA ligase (ADP-forming) activity(GO:0052687) (3R)-3-isopropenyl-6-oxoheptanoate:CoA ligase (AMP-forming) activity(GO:0052688) pristanate-CoA ligase activity(GO:0070251) malonyl-CoA synthetase activity(GO:0090409)
0.0	0.1	GO:0004579	dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.0	0.0	GO:0008515	sucrose:proton symporter activity(GO:0008506) sucrose transmembrane transporter activity(GO:0008515) disaccharide transmembrane transporter activity(GO:0015154) oligosaccharide transmembrane transporter activity(GO:0015157)
0.0	0.3	GO:0070330	aromatase activity(GO:0070330)
0.0	0.1	GO:0004887	thyroid hormone receptor activity(GO:0004887)
0.0	0.0	GO:0034056	estrogen response element binding(GO:0034056)
0.0	0.0	GO:0035514	DNA demethylase activity(GO:0035514)
0.0	0.0	GO:0044323	retinoic acid-responsive element binding(GO:0044323)
0.0	0.5	GO:0030374	ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374)
0.0	0.1	GO:0004383	guanylate cyclase activity(GO:0004383)
0.0	0.1	GO:0008140	cAMP response element binding protein binding(GO:0008140)

Gene overrepresentation in curated gene sets: canonical pathways category:

Total log-likelihood	Term	Description
0.3	PID P38 MK2 PATHWAY	p38 signaling mediated by MAPKAP kinases
0.1	PID P38 GAMMA DELTA PATHWAY	Signaling mediated by p38-gamma and p38-delta
0.2	PID SYNDECAN 3 PATHWAY	Syndecan-3-mediated signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Total log-likelihood	Term	Description
0.3	REACTOME TRYPTOPHAN CATABOLISM	Genes involved in Tryptophan catabolism
0.1	REACTOME ETHANOL OXIDATION	Genes involved in Ethanol oxidation
0.3	REACTOME VITAMIN B5 PANTOTHENATE METABOLISM	Genes involved in Vitamin B5 (pantothenate) metabolism
0.2	REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING	Genes involved in Formation of ATP by chemiosmotic coupling
0.3	REACTOME METABOLISM OF POLYAMINES	Genes involved in Metabolism of polyamines
0.2	REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA	Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.3	REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION	Genes involved in GABA synthesis, release, reuptake and degradation
0.1	REACTOME GLUCURONIDATION	Genes involved in Glucuronidation
0.2	REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES	Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.1	REACTOME REGULATION OF COMPLEMENT CASCADE	Genes involved in Regulation of Complement cascade
0.2	REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS	Genes involved in Glycogen breakdown (glycogenolysis)
0.2	REACTOME SIGNALING BY CONSTITUTIVELY ACTIVE EGFR	Genes involved in Signaling by constitutively active EGFR
0.3	REACTOME MYOGENESIS	Genes involved in Myogenesis
0.1	REACTOME ACTIVATION OF RAC	Genes involved in Activation of Rac