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ENCSR904DTN: DNase-seq of mouse liver in constant darkness

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for Trp73

Z-value: 1.52

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Transcription factors associated with Trp73

Gene Symbol	Gene ID	Gene Info
Trp73 Ensembl NCBI MGI UniProt	ENSMUSG00000029026.10	Trp73

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

Gene	Promoter	Distance	Association probability	Pearson corr. coef.	P-value	Plot
Trp73	chr4_154081057_154081217	4185	0.129702	0.90	1.6e-02	Click!
Trp73	chr4_154105367_154105533	8277	0.114828	-0.78	6.7e-02	Click!
Trp73	chr4_154118930_154119081	2400	0.180872	-0.15	7.8e-01	Click!

Activity of the Trp73 motif across conditions

Conditions sorted by the z-value of the Trp73 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr11_72243451_72243602	0.96	1700051A21Rik	RIKEN cDNA 1700051A21 gene	22895	0.09
chr14_66672460_66672626	0.82	Adra1a	adrenergic receptor, alpha 1a	36987	0.17
chr5_134155757_134155938	0.77	Rcc1l	reculator of chromosome condensation 1 like	12413	0.13
chr11_107703521_107703697	0.74	Cacng1	calcium channel, voltage-dependent, gamma subunit 1	12913	0.16
chr7_145069187_145069341	0.70	Gm45181	predicted gene 45181	93732	0.07
chr17_84183727_84183878	0.69	Gm36279	predicted gene, 36279	1954	0.27
chr6_4749062_4749219	0.68	Peg10	paternally expressed 10	1734	0.27
chr13_28930434_28930607	0.68	Sox4	SRY (sex determining region Y)-box 4	23193	0.17
chr4_57320936_57321111	0.66	Ptpn3	protein tyrosine phosphatase, non-receptor type 3	19186	0.15
chr15_31568768_31568949	0.66	Cmbl	carboxymethylenebutenolidase-like (Pseudomonas)	60	0.96
chr8_46385009_46385281	0.64	Gm45253	predicted gene 45253	743	0.6
chr9_66802090_66802293	0.63	BC050972	cDNA sequence BC050972	368	0.78
chr10_41884316_41884467	0.62	Sesn1	sestrin 1	3048	0.28
chrX_12249219_12249376	0.62	Gm14521	predicted gene 14521	69230	0.11
chr12_75746027_75746188	0.58	Sgpp1	sphingosine-1-phosphate phosphatase 1	10378	0.23
chr9_123237941_123238104	0.58	Cdcp1	CUB domain containing protein 1	21984	0.13
chr5_116390234_116390471	0.56	4930562A09Rik	RIKEN cDNA 4930562A09 gene	2448	0.2
chr4_148455809_148455972	0.56	Mtor	mechanistic target of rapamycin kinase	7265	0.14
chr9_43673281_43673432	0.56	Gm5364	predicted gene 5364	9697	0.16
chr4_59331623_59331836	0.55	Susd1	sushi domain containing 1	1293	0.48
chr15_40124618_40124784	0.55	9330182O14Rik	RIKEN cDNA 9330182O14 gene	9664	0.19
chr7_46830137_46830394	0.54	Gm45308	predicted gene 45308	2199	0.15
chr17_8343757_8343973	0.53	Prr18	proline rich 18	3126	0.15
chr11_76893564_76893941	0.52	Tmigd1	transmembrane and immunoglobulin domain containing 1	8407	0.18
chr3_122513095_122513259	0.51	Bcar3	breast cancer anti-estrogen resistance 3	955	0.47
chr8_88555776_88556143	0.50	Gm45496	predicted gene 45496	4074	0.24
chr7_132729545_132729708	0.49	Fam53b	family with sequence similarity 53, member B	47290	0.12
chr8_126839083_126839255	0.49	A630001O12Rik	RIKEN cDNA A630001O12 gene	64	0.98
chr15_54963168_54963544	0.49	Gm26684	predicted gene, 26684	10408	0.15
chr9_63201496_63201967	0.48	Skor1	SKI family transcriptional corepressor 1	52770	0.12
chr1_134232873_134233068	0.47	Adora1	adenosine A1 receptor	1608	0.3
chr3_105705277_105705434	0.47	Inka2	inka box actin regulator 2	103	0.95
chr3_83040525_83040907	0.47	Fgb	fibrinogen beta chain	9147	0.14
chr10_20673746_20674078	0.47	Gm17230	predicted gene 17230	48277	0.14
chr12_8778168_8778353	0.46	Sdc1	syndecan 1	6457	0.19
chr2_23071515_23071743	0.46	Acbd5	acyl-Coenzyme A binding domain containing 5	2178	0.29
chr12_103437726_103437893	0.46	Ifi27	interferon, alpha-inducible protein 27	182	0.89
chr7_129790460_129790637	0.45	Gm44778	predicted gene 44778	42498	0.18
chr2_173152634_173153061	0.45	Pck1	phosphoenolpyruvate carboxykinase 1, cytosolic	201	0.93
chr10_128961226_128961428	0.45	Mettl7b	methyltransferase like 7B	339	0.74
chr6_145477400_145477576	0.44	Gm25373	predicted gene, 25373	13299	0.17
chr19_23110526_23110678	0.44	2410080I02Rik	RIKEN cDNA 2410080I02 gene	24298	0.14
chr1_78860116_78860328	0.44	Gm29187	predicted gene 29187	38964	0.15
chr12_94190897_94191174	0.44	Gm18749	predicted gene, 18749	131334	0.05
chr7_19785264_19785423	0.44	Cblc	Casitas B-lineage lymphoma c	97	0.91
chr18_68011811_68011962	0.43	Ldlrad4	low density lipoprotein receptor class A domain containing 4	78629	0.09
chr8_120856918_120857076	0.43	Gm26878	predicted gene, 26878	23209	0.19
chr9_88697034_88697219	0.42	Gm37226	predicted gene, 37226	10940	0.1
chr17_27557519_27557704	0.42	Hmga1	high mobility group AT-hook 1	916	0.28
chr10_127962820_127963065	0.42	Gm47949	predicted gene, 47949	1386	0.24
chr10_17551883_17552066	0.41	Gm47770	predicted gene, 47770	25060	0.17
chr13_28629708_28629873	0.41	Mir6368	microRNA 6368	81083	0.09
chr2_32607757_32607919	0.41	St6galnac6	ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6	233	0.82
chr9_65461146_65461312	0.41	Spg21	SPG21, maspardin	276	0.85
chr6_88627459_88627634	0.41	Kbtbd12	kelch repeat and BTB (POZ) domain containing 12	98	0.97
chr1_93479013_93479164	0.40	Septin2	septin 2	20	0.79
chr2_168003768_168003979	0.40	Gm14236	predicted gene 14236	6656	0.16
chr6_113828811_113828998	0.39	Gm44167	predicted gene, 44167	29220	0.13
chr7_87246448_87246638	0.38	Nox4	NADPH oxidase 4	106	0.97
chr4_130112167_130112332	0.38	Pef1	penta-EF hand domain containing 1	4693	0.16
chr15_27634069_27634229	0.38	Gm46506	predicted gene, 46506	2362	0.24
chr5_120611405_120611556	0.38	Rita1	RBPJ interacting and tubulin associated 1	157	0.87
chr3_22078075_22078419	0.38	Tbl1xr1	transducin (beta)-like 1X-linked receptor 1	963	0.47
chr8_119400211_119400396	0.38	Mlycd	malonyl-CoA decarboxylase	5405	0.17
chr16_95769487_95769687	0.37	Gm37259	predicted gene, 37259	9751	0.17
chr12_3894495_3894825	0.37	Dnmt3a	DNA methyltransferase 3A	164	0.95
chr3_52897779_52897957	0.37	Gm20750	predicted gene, 20750	29798	0.16
chr7_112170278_112170643	0.37	Dkk3	dickkopf WNT signaling pathway inhibitor 3	11403	0.25
chr6_50986659_50986810	0.37	Gm44402	predicted gene, 44402	19466	0.22
chr17_29431823_29432064	0.37	Gm36199	predicted gene, 36199	892	0.45
chr16_23063931_23064082	0.36	Kng1	kininogen 1	5613	0.08
chr14_69732071_69732222	0.36	Chmp7	charged multivesicular body protein 7	388	0.79
chr9_61479695_61479879	0.36	Gm47240	predicted gene, 47240	6801	0.2
chr16_21866250_21866424	0.36	Gm26744	predicted gene, 26744	20561	0.11
chr9_43465193_43465354	0.36	Gm28215	predicted gene 28215	4149	0.22
chr12_86888572_86888744	0.36	Irf2bpl	interferon regulatory factor 2 binding protein-like	3860	0.22
chr5_142440070_142440526	0.36	Ap5z1	adaptor-related protein complex 5, zeta 1 subunit	23646	0.17
chr14_39195795_39195969	0.35	Gm20642	predicted gene 20642	24189	0.28
chr17_43326768_43326935	0.35	Adgrf5	adhesion G protein-coupled receptor F5	33600	0.19
chr7_132245773_132246102	0.35	Chst15	carbohydrate sulfotransferase 15	32688	0.14
chr15_79327440_79327599	0.35	Pla2g6	phospholipase A2, group VI	445	0.7
chr1_36316895_36317108	0.35	Arid5a	AT rich interactive domain 5A (MRF1-like)	26	0.97
chr5_149014913_149015064	0.35	Gm15411	predicted gene 15411	796	0.43
chr5_7955475_7955629	0.35	Gm30835	predicted gene, 30835	4794	0.18
chr15_75675616_75675767	0.35	Top1mt	DNA topoisomerase 1, mitochondrial	3109	0.15
chr16_31994081_31994256	0.35	Hmgb1-ps6	high mobility group box 1, pseudogene 6	2300	0.13
chr8_10879580_10879754	0.35	B930025P03Rik	RIKEN cDNA B930025P03 gene	2768	0.15
chr5_122730871_122731058	0.35	P2rx4	purinergic receptor P2X, ligand-gated ion channel 4	3300	0.16
chr10_93282645_93282796	0.34	Elk3	ELK3, member of ETS oncogene family	28091	0.14
chr5_63936466_63936784	0.34	Rell1	RELT-like 1	5711	0.18
chr10_93513920_93514254	0.34	Hal	histidine ammonia lyase	12962	0.13
chr13_52048885_52049060	0.34	Gm37872	predicted gene, 37872	27045	0.17
chr4_155564029_155564190	0.34	Nadk	NAD kinase	37	0.96
chr5_65107589_65107740	0.34	Klhl5	kelch-like 5	125	0.96
chr15_57979415_57979570	0.34	Fam83a	family with sequence similarity 83, member A	5927	0.18
chr2_125263901_125264052	0.34	A530010F05Rik	RIKEN cDNA A530010F05 gene	10588	0.16
chr16_23997987_23998171	0.33	Bcl6	B cell leukemia/lymphoma 6	9227	0.16
chr4_83270585_83270742	0.33	Ttc39b	tetratricopeptide repeat domain 39B	4624	0.22
chr19_23071512_23071878	0.33	C330002G04Rik	RIKEN cDNA C330002G04 gene	4158	0.22
chr11_3255972_3256130	0.33	Drg1	developmentally regulated GTP binding protein 1	3192	0.16
chr7_45782387_45782600	0.33	Lmtk3	lemur tyrosine kinase 3	1245	0.21
chr8_111624424_111624606	0.33	Ldhd	lactate dehydrogenase D	4072	0.18
chr6_145469440_145469652	0.33	Gm25373	predicted gene, 25373	5357	0.18
chr2_163736041_163736204	0.33	Ada	adenosine deaminase	5256	0.18
chr11_69601181_69601332	0.33	Atp1b2	ATPase, Na+/K+ transporting, beta 2 polypeptide	1485	0.15
chr2_29295626_29296066	0.33	6530402F18Rik	RIKEN cDNA 6530402F18 gene	42840	0.12
chrX_159256995_159257386	0.33	Rps6ka3	ribosomal protein S6 kinase polypeptide 3	1064	0.63
chr8_34455567_34455746	0.32	Gm45349	predicted gene 45349	17339	0.17
chr8_113141217_113141373	0.32	Gm10280	predicted gene 10280	74033	0.12
chr4_144977157_144977352	0.32	Vps13d	vacuolar protein sorting 13D	6707	0.21
chr7_130855841_130856000	0.32	Plekha1	pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1	9836	0.16
chr3_84324115_84324266	0.32	Trim2	tripartite motif-containing 2	17313	0.23
chr4_138972772_138972945	0.32	Tmco4	transmembrane and coiled-coil domains 4	30	0.97
chr11_69416113_69416276	0.32	Kdm6b	KDM1 lysine (K)-specific demethylase 6B	2519	0.13
chr15_88704398_88704558	0.32	Brd1	bromodomain containing 1	3614	0.26
chr4_117978300_117978463	0.32	9530034E10Rik	RIKEN cDNA 9530034E10 gene	3345	0.19
chr1_136955166_136955491	0.32	Nr5a2	nuclear receptor subfamily 5, group A, member 2	1698	0.42
chr2_33177813_33178235	0.32	Gm13528	predicted gene 13528	122	0.95
chr10_37837777_37837948	0.32	Gm24710	predicted gene, 24710	93818	0.09
chr11_97437884_97438051	0.32	Arhgap23	Rho GTPase activating protein 23	1682	0.32
chr14_73445827_73446221	0.32	Gm4266	predicted gene 4266	47069	0.11
chr3_105895379_105895692	0.32	Adora3	adenosine A3 receptor	8886	0.12
chr10_5823911_5824075	0.31	Mtrf1l	mitochondrial translational release factor 1-like	83	0.98
chr9_108095047_108095215	0.31	Apeh	acylpeptide hydrolase	525	0.53
chr5_134554086_134554240	0.31	Clip2	CAP-GLY domain containing linker protein 2	1729	0.19
chr3_10298177_10298449	0.31	Fabp12	fatty acid binding protein 12	2861	0.14
chr13_59009996_59010157	0.31	Gm34245	predicted gene, 34245	68220	0.09
chr2_167831188_167831379	0.31	1200007C13Rik	RIKEN cDNA 1200007C13 gene	2363	0.25
chr9_67617399_67617691	0.31	Tln2	talin 2	57842	0.12
chr12_85170010_85170261	0.31	Pgf	placental growth factor	240	0.87
chr9_13890286_13890446	0.31	Gm7588	predicted gene 7588	21660	0.15
chr15_78340778_78340947	0.31	Mir7676-2	microRNA 7676-2	7737	0.12
chr8_115718761_115718923	0.31	Maf	avian musculoaponeurotic fibrosarcoma oncogene homolog	11048	0.23
chr18_65024180_65024941	0.31	Nedd4l	neural precursor cell expressed, developmentally down-regulated gene 4-like	836	0.66
chr15_12209919_12210084	0.31	Mtmr12	myotubularin related protein 12	4883	0.13
chr8_41035719_41035932	0.31	Mtus1	mitochondrial tumor suppressor 1	3762	0.18
chr6_113062410_113062570	0.30	Gm22591	predicted gene, 22591	1792	0.2
chr10_67056022_67056194	0.30	Reep3	receptor accessory protein 3	18786	0.17
chr11_95252192_95252390	0.30	Tac4	tachykinin 4	9238	0.14
chr11_98769689_98769972	0.30	Nr1d1	nuclear receptor subfamily 1, group D, member 1	596	0.57
chr9_96116991_96117142	0.30	Gk5	glycerol kinase 5 (putative)	2296	0.3
chr2_110290286_110290470	0.30	Bbox1	butyrobetaine (gamma), 2-oxoglutarate dioxygenase 1 (gamma-butyrobetaine hydroxylase)	15363	0.21
chr15_76695232_76695387	0.30	Gpt	glutamic pyruvic transaminase, soluble	407	0.62
chr6_5517592_5517751	0.30	Pdk4	pyruvate dehydrogenase kinase, isoenzyme 4	21362	0.26
chr13_39657075_39657270	0.30	Gm47352	predicted gene, 47352	7661	0.21
chr13_102646594_102646778	0.30	Gm47014	predicted gene, 47014	42153	0.14
chr10_80405043_80405226	0.30	Uqcr11	ubiquinol-cytochrome c reductase, complex III subunit XI	1632	0.16
chr5_66328869_66329031	0.30	Gm43790	predicted gene 43790	5933	0.14
chr11_94274186_94274507	0.30	Gm21885	predicted gene, 21885	7527	0.15
chr15_59786780_59786984	0.29	Gm19510	predicted gene, 19510	8077	0.27
chr2_173159311_173159586	0.29	Pck1	phosphoenolpyruvate carboxykinase 1, cytosolic	6366	0.18
chr1_165661837_165661988	0.29	Gm18407	predicted gene, 18407	17224	0.1
chr16_24238329_24238511	0.29	Gm31814	predicted gene, 31814	21896	0.19
chr18_56399298_56399460	0.29	Gramd3	GRAM domain containing 3	958	0.58
chr11_97703209_97703365	0.29	Psmb3	proteasome (prosome, macropain) subunit, beta type 3	112	0.9
chr1_121332590_121332782	0.29	Insig2	insulin induced gene 2	97	0.96
chr10_84581307_84581543	0.29	Tcp11l2	t-complex 11 (mouse) like 2	4528	0.15
chr6_51600845_51601052	0.29	Gm22914	predicted gene, 22914	20684	0.2
chr2_84937644_84937820	0.29	Slc43a3	solute carrier family 43, member 3	842	0.5
chr8_127184160_127184328	0.29	Pard3	par-3 family cell polarity regulator	12840	0.27
chr1_191628618_191628785	0.28	Gm37349	predicted gene, 37349	31054	0.13
chr9_65237582_65237733	0.28	Parp16	poly (ADP-ribose) polymerase family, member 16	22503	0.1
chr6_108660022_108660191	0.28	Bhlhe40	basic helix-loop-helix family, member e40	523	0.57
chr5_118560730_118560903	0.28	Med13l	mediator complex subunit 13-like	77	0.96
chr2_136986812_136986999	0.28	Slx4ip	SLX4 interacting protein	81362	0.08
chr10_61383039_61383232	0.28	Pald1	phosphatase domain containing, paladin 1	395	0.75
chr9_74528700_74528872	0.28	Gm28622	predicted gene 28622	32592	0.18
chr11_102240756_102240907	0.28	Hrob	homologous recombination factor with OB-fold	8051	0.09
chr4_8714834_8715372	0.28	Chd7	chromodomain helicase DNA binding protein 7	4763	0.29
chr2_24742080_24742251	0.28	Cacna1b	calcium channel, voltage-dependent, N type, alpha 1B subunit	20882	0.16
chr1_184069803_184070002	0.28	Dusp10	dual specificity phosphatase 10	35521	0.18
chr9_107657610_107657902	0.28	Slc38a3	solute carrier family 38, member 3	495	0.58
chr9_20951552_20951703	0.28	Dnmt1	DNA methyltransferase (cytosine-5) 1	978	0.34
chr3_133534210_133534372	0.28	Tet2	tet methylcytosine dioxygenase 2	9995	0.17
chr16_95824094_95824245	0.28	2810404F17Rik	RIKEN cDNA 2810404F17 gene	15852	0.17
chr8_119862106_119862265	0.28	Klhl36	kelch-like 36	81	0.97
chr4_152010395_152010554	0.28	Gm9768	predicted gene 9768	855	0.38
chr6_121992123_121992633	0.28	Mug2	murinoglobulin 2	14383	0.19
chr11_120695849_120696008	0.27	Aspscr1	alveolar soft part sarcoma chromosome region, candidate 1 (human)	6586	0.06
chr17_45691675_45691964	0.27	Mrpl14	mitochondrial ribosomal protein L14	3597	0.14
chr12_17425859_17426047	0.27	Gm36752	predicted gene, 36752	10665	0.19
chr2_25225323_25225479	0.27	Tubb4b	tubulin, beta 4B class IVB	699	0.33
chr11_106122887_106123054	0.27	Gm11672	predicted gene 11672	4381	0.13
chr1_171329168_171329338	0.27	Dedd	death effector domain-containing	108	0.89
chr10_79936936_79937107	0.27	Arid3a	AT rich interactive domain 3A (BRIGHT-like)	6597	0.06
chr2_167719609_167719764	0.27	A530013C23Rik	RIKEN cDNA A530013C23 gene	28505	0.1
chr1_72851799_72851950	0.27	Igfbp2	insulin-like growth factor binding protein 2	3175	0.28
chr12_82337746_82337908	0.27	Sipa1l1	signal-induced proliferation-associated 1 like 1	4440	0.32
chr6_87513163_87513315	0.27	Arhgap25	Rho GTPase activating protein 25	16925	0.14
chr13_98594038_98594200	0.27	Gm4815	predicted gene 4815	19382	0.12
chr19_10193896_10194210	0.27	Fads1	fatty acid desaturase 1	734	0.46
chr10_77589222_77589404	0.27	Pttg1ip	pituitary tumor-transforming 1 interacting protein	81	0.94
chr18_43250442_43250599	0.27	Stk32a	serine/threonine kinase 32A	7480	0.24
chr2_144256907_144257089	0.27	Snx5	sorting nexin 5	1595	0.22
chr2_137080581_137080763	0.26	Jag1	jagged 1	5277	0.31
chr9_106453257_106453493	0.26	Pcbp4	poly(rC) binding protein 4	32	0.86
chr11_95032963_95033336	0.26	Gm11513	predicted gene 11513	390	0.76
chr6_121196988_121197205	0.26	Gm44014	predicted gene, 44014	1087	0.4
chr8_4258328_4258479	0.26	Ctxn1	cortexin 1	871	0.34
chr12_80218314_80218489	0.26	Gm47767	predicted gene, 47767	9158	0.15

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of Trp73

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View png image

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	0.6	GO:0051365	cellular response to potassium ion starvation(GO:0051365)
0.1	0.4	GO:2000304	positive regulation of sphingolipid biosynthetic process(GO:0090154) positive regulation of ceramide biosynthetic process(GO:2000304)
0.1	0.5	GO:0046499	S-adenosylmethioninamine metabolic process(GO:0046499)
0.1	0.1	GO:0055005	ventricular cardiac myofibril assembly(GO:0055005)
0.1	0.3	GO:0032074	negative regulation of nuclease activity(GO:0032074)
0.1	0.3	GO:0035887	aortic smooth muscle cell differentiation(GO:0035887)
0.1	0.3	GO:0006741	NADP biosynthetic process(GO:0006741)
0.1	0.2	GO:0034443	negative regulation of lipoprotein oxidation(GO:0034443)
0.1	0.3	GO:0070126	mitochondrial translational termination(GO:0070126)
0.1	0.2	GO:0052490	negative regulation by symbiont of host apoptotic process(GO:0033668) negative regulation by symbiont of host programmed cell death(GO:0052041) negative regulation by organism of programmed cell death in other organism involved in symbiotic interaction(GO:0052490)
0.1	0.2	GO:0046951	ketone body biosynthetic process(GO:0046951)
0.1	0.2	GO:0043152	induction of bacterial agglutination(GO:0043152)
0.1	0.3	GO:0061113	pancreas morphogenesis(GO:0061113)
0.1	0.2	GO:0010735	positive regulation of transcription via serum response element binding(GO:0010735)
0.1	0.5	GO:0007175	negative regulation of epidermal growth factor-activated receptor activity(GO:0007175)
0.1	0.2	GO:0006419	alanyl-tRNA aminoacylation(GO:0006419)
0.1	0.1	GO:0015817	histidine transport(GO:0015817)
0.1	0.2	GO:0002636	positive regulation of germinal center formation(GO:0002636)
0.1	0.2	GO:1902071	regulation of hypoxia-inducible factor-1alpha signaling pathway(GO:1902071)
0.1	0.2	GO:0006114	glycerol biosynthetic process(GO:0006114)
0.1	0.2	GO:0016479	negative regulation of transcription from RNA polymerase I promoter(GO:0016479)
0.1	0.2	GO:0021593	rhombomere morphogenesis(GO:0021593)
0.0	0.1	GO:0001983	baroreceptor response to increased systemic arterial blood pressure(GO:0001983)
0.0	0.1	GO:0046341	CDP-diacylglycerol metabolic process(GO:0046341)
0.0	0.1	GO:0030242	pexophagy(GO:0030242)
0.0	0.2	GO:2001286	regulation of caveolin-mediated endocytosis(GO:2001286)
0.0	0.1	GO:0035425	autocrine signaling(GO:0035425)
0.0	0.1	GO:0048296	isotype switching to IgA isotypes(GO:0048290) regulation of isotype switching to IgA isotypes(GO:0048296)
0.0	0.2	GO:0050847	progesterone receptor signaling pathway(GO:0050847)
0.0	0.0	GO:1904502	regulation of lipophagy(GO:1904502) positive regulation of lipophagy(GO:1904504)
0.0	0.6	GO:0043518	negative regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043518)
0.0	0.1	GO:0071787	endoplasmic reticulum tubular network assembly(GO:0071787)
0.0	0.2	GO:0006686	sphingomyelin biosynthetic process(GO:0006686)
0.0	0.1	GO:0002071	glandular epithelial cell maturation(GO:0002071)
0.0	0.2	GO:0019244	lactate biosynthetic process from pyruvate(GO:0019244) lactate biosynthetic process(GO:0019249)
0.0	0.2	GO:0032898	neurotrophin production(GO:0032898)
0.0	0.3	GO:0060363	cranial suture morphogenesis(GO:0060363)
0.0	0.2	GO:0098902	regulation of membrane depolarization during action potential(GO:0098902)
0.0	0.1	GO:0000379	tRNA-type intron splice site recognition and cleavage(GO:0000379)
0.0	0.1	GO:1990705	cholangiocyte proliferation(GO:1990705)
0.0	0.1	GO:0035905	ascending aorta development(GO:0035905) ascending aorta morphogenesis(GO:0035910)
0.0	0.2	GO:0086023	adrenergic receptor signaling pathway involved in heart process(GO:0086023)
0.0	0.2	GO:0052805	histidine catabolic process(GO:0006548) imidazole-containing compound catabolic process(GO:0052805)
0.0	0.1	GO:0009177	deoxyribonucleoside monophosphate biosynthetic process(GO:0009157) pyrimidine deoxyribonucleoside monophosphate biosynthetic process(GO:0009177)
0.0	0.3	GO:0061469	regulation of type B pancreatic cell proliferation(GO:0061469)
0.0	0.2	GO:0010991	negative regulation of SMAD protein complex assembly(GO:0010991)
0.0	0.1	GO:0009597	detection of virus(GO:0009597)
0.0	0.1	GO:0006556	S-adenosylmethionine biosynthetic process(GO:0006556)
0.0	0.1	GO:0000710	meiotic mismatch repair(GO:0000710)
0.0	0.1	GO:1903061	positive regulation of protein lipidation(GO:1903061)
0.0	0.3	GO:0009312	oligosaccharide biosynthetic process(GO:0009312)
0.0	0.1	GO:0051611	negative regulation of neurotransmitter uptake(GO:0051581) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612)
0.0	0.4	GO:0050667	homocysteine metabolic process(GO:0050667)
0.0	0.1	GO:0006578	amino-acid betaine biosynthetic process(GO:0006578)
0.0	0.1	GO:0060264	regulation of respiratory burst involved in inflammatory response(GO:0060264)
0.0	0.1	GO:0000733	DNA strand renaturation(GO:0000733)
0.0	0.2	GO:1902033	regulation of hematopoietic stem cell proliferation(GO:1902033)
0.0	0.2	GO:0030578	PML body organization(GO:0030578)
0.0	0.1	GO:0006543	glutamine catabolic process(GO:0006543)
0.0	0.2	GO:0035542	regulation of SNARE complex assembly(GO:0035542)
0.0	0.1	GO:0006842	tricarboxylic acid transport(GO:0006842) citrate transport(GO:0015746)
0.0	0.2	GO:0090043	regulation of tubulin deacetylation(GO:0090043)
0.0	0.1	GO:1990414	replication-born double-strand break repair via sister chromatid exchange(GO:1990414)
0.0	0.1	GO:0007403	glial cell fate determination(GO:0007403)
0.0	0.2	GO:0006048	UDP-N-acetylglucosamine biosynthetic process(GO:0006048)
0.0	0.1	GO:0030423	targeting of mRNA for destruction involved in RNA interference(GO:0030423)
0.0	0.2	GO:0010815	bradykinin catabolic process(GO:0010815)
0.0	0.1	GO:0014745	negative regulation of muscle adaptation(GO:0014745)
0.0	0.1	GO:0061156	pulmonary artery morphogenesis(GO:0061156)
0.0	0.3	GO:0045324	late endosome to vacuole transport(GO:0045324)
0.0	0.2	GO:0035520	monoubiquitinated protein deubiquitination(GO:0035520)
0.0	0.1	GO:0046655	folic acid metabolic process(GO:0046655)
0.0	0.1	GO:1990314	cellular response to insulin-like growth factor stimulus(GO:1990314)
0.0	0.1	GO:0046292	formaldehyde metabolic process(GO:0046292)
0.0	0.1	GO:0003223	ventricular compact myocardium morphogenesis(GO:0003223)
0.0	0.1	GO:0002606	positive regulation of dendritic cell antigen processing and presentation(GO:0002606)
0.0	0.1	GO:0035526	retrograde transport, plasma membrane to Golgi(GO:0035526)
0.0	0.1	GO:0030091	protein repair(GO:0030091)
0.0	0.2	GO:1904262	negative regulation of TORC1 signaling(GO:1904262)
0.0	0.4	GO:1900151	regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay(GO:1900151) positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay(GO:1900153)
0.0	0.1	GO:0032345	negative regulation of aldosterone metabolic process(GO:0032345) negative regulation of aldosterone biosynthetic process(GO:0032348) negative regulation of cortisol biosynthetic process(GO:2000065)
0.0	0.1	GO:0071447	cellular response to hydroperoxide(GO:0071447)
0.0	0.1	GO:1904017	response to Thyroglobulin triiodothyronine(GO:1904016) cellular response to Thyroglobulin triiodothyronine(GO:1904017)
0.0	0.1	GO:0009233	menaquinone metabolic process(GO:0009233)
0.0	0.0	GO:0014735	regulation of muscle atrophy(GO:0014735)
0.0	0.1	GO:0010510	regulation of acetyl-CoA biosynthetic process from pyruvate(GO:0010510) regulation of acyl-CoA biosynthetic process(GO:0050812)
0.0	0.1	GO:1903799	negative regulation of production of miRNAs involved in gene silencing by miRNA(GO:1903799)
0.0	0.1	GO:0033194	response to hydroperoxide(GO:0033194)
0.0	0.1	GO:0007619	courtship behavior(GO:0007619)
0.0	0.2	GO:0043619	regulation of transcription from RNA polymerase II promoter in response to oxidative stress(GO:0043619)
0.0	0.1	GO:1903553	positive regulation of extracellular exosome assembly(GO:1903553)
0.0	0.1	GO:0001842	neural fold formation(GO:0001842)
0.0	0.1	GO:0032485	regulation of Ral protein signal transduction(GO:0032485)
0.0	0.1	GO:0090259	regulation of retinal ganglion cell axon guidance(GO:0090259)
0.0	0.1	GO:0000189	MAPK import into nucleus(GO:0000189)
0.0	0.0	GO:0044339	canonical Wnt signaling pathway involved in osteoblast differentiation(GO:0044339)
0.0	0.1	GO:0002741	positive regulation of cytokine secretion involved in immune response(GO:0002741)
0.0	0.1	GO:0051572	negative regulation of histone H3-K4 methylation(GO:0051572)
0.0	0.1	GO:2000394	positive regulation of lamellipodium morphogenesis(GO:2000394)
0.0	0.2	GO:0018095	protein polyglutamylation(GO:0018095)
0.0	0.2	GO:0072673	lamellipodium morphogenesis(GO:0072673)
0.0	0.5	GO:0019373	epoxygenase P450 pathway(GO:0019373)
0.0	0.1	GO:0090283	regulation of protein glycosylation in Golgi(GO:0090283)
0.0	0.1	GO:0071073	positive regulation of phospholipid biosynthetic process(GO:0071073)
0.0	0.1	GO:0006658	phosphatidylserine metabolic process(GO:0006658)
0.0	0.1	GO:0032439	endosome localization(GO:0032439)
0.0	0.0	GO:0097296	activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:0097296)
0.0	0.1	GO:0048861	leukemia inhibitory factor signaling pathway(GO:0048861)
0.0	0.1	GO:0070327	thyroid hormone transport(GO:0070327)
0.0	0.2	GO:0045075	interleukin-12 biosynthetic process(GO:0042090) regulation of interleukin-12 biosynthetic process(GO:0045075)
0.0	0.1	GO:0000350	generation of catalytic spliceosome for second transesterification step(GO:0000350)
0.0	0.1	GO:0006123	mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.0	0.1	GO:0035754	B cell chemotaxis(GO:0035754)
0.0	0.0	GO:0070947	neutrophil mediated killing of fungus(GO:0070947)
0.0	0.1	GO:0007525	somatic muscle development(GO:0007525)
0.0	0.1	GO:0007084	mitotic nuclear envelope reassembly(GO:0007084)
0.0	0.1	GO:0046501	protoporphyrinogen IX metabolic process(GO:0046501)
0.0	0.1	GO:0090290	positive regulation of osteoclast proliferation(GO:0090290)
0.0	0.1	GO:0033133	positive regulation of glucokinase activity(GO:0033133)
0.0	0.1	GO:0000185	activation of MAPKKK activity(GO:0000185)
0.0	0.1	GO:1902202	regulation of hepatocyte growth factor receptor signaling pathway(GO:1902202)
0.0	0.3	GO:0043011	myeloid dendritic cell differentiation(GO:0043011)
0.0	0.3	GO:0020027	hemoglobin metabolic process(GO:0020027)
0.0	0.0	GO:0051610	serotonin uptake(GO:0051610)
0.0	0.0	GO:0032489	regulation of Cdc42 protein signal transduction(GO:0032489)
0.0	0.1	GO:0046543	development of secondary female sexual characteristics(GO:0046543)
0.0	0.1	GO:0045835	negative regulation of meiotic nuclear division(GO:0045835)
0.0	0.1	GO:0070423	nucleotide-binding oligomerization domain containing signaling pathway(GO:0070423) nucleotide-binding oligomerization domain containing 2 signaling pathway(GO:0070431)
0.0	0.1	GO:0006545	glycine biosynthetic process(GO:0006545)
0.0	0.1	GO:0070837	dehydroascorbic acid transport(GO:0070837)
0.0	0.0	GO:0043134	hindgut contraction(GO:0043133) regulation of hindgut contraction(GO:0043134)
0.0	0.2	GO:0060670	branching involved in labyrinthine layer morphogenesis(GO:0060670)
0.0	0.3	GO:0030488	tRNA methylation(GO:0030488)
0.0	0.0	GO:0002378	immunoglobulin biosynthetic process(GO:0002378)
0.0	0.0	GO:0002432	granuloma formation(GO:0002432)
0.0	0.1	GO:0009838	abscission(GO:0009838)
0.0	0.0	GO:0016561	protein import into peroxisome matrix, translocation(GO:0016561)
0.0	0.0	GO:0071504	response to heparin(GO:0071503) cellular response to heparin(GO:0071504)
0.0	0.1	GO:0032836	glomerular basement membrane development(GO:0032836)
0.0	0.3	GO:0035066	positive regulation of histone acetylation(GO:0035066)
0.0	0.1	GO:0038031	non-canonical Wnt signaling pathway via JNK cascade(GO:0038031)
0.0	0.2	GO:0010801	negative regulation of peptidyl-threonine phosphorylation(GO:0010801)
0.0	0.0	GO:0001827	inner cell mass cell fate commitment(GO:0001827)
0.0	0.0	GO:0018076	N-terminal peptidyl-lysine acetylation(GO:0018076)
0.0	0.0	GO:2001032	regulation of double-strand break repair via nonhomologous end joining(GO:2001032)
0.0	0.1	GO:0071557	histone H3-K27 demethylation(GO:0071557)
0.0	0.1	GO:0019276	UDP-N-acetylgalactosamine metabolic process(GO:0019276)
0.0	0.1	GO:0001920	negative regulation of receptor recycling(GO:0001920)
0.0	0.0	GO:0070375	ERK5 cascade(GO:0070375)
0.0	0.1	GO:0014028	notochord formation(GO:0014028)
0.0	0.1	GO:0051561	positive regulation of mitochondrial calcium ion concentration(GO:0051561)
0.0	0.0	GO:0060331	negative regulation of response to interferon-gamma(GO:0060331) negative regulation of interferon-gamma-mediated signaling pathway(GO:0060336)
0.0	0.1	GO:0031274	positive regulation of pseudopodium assembly(GO:0031274)
0.0	0.1	GO:0097461	ferric iron import(GO:0033216) ferric iron import into cell(GO:0097461)
0.0	0.0	GO:0032058	positive regulation of translational initiation in response to stress(GO:0032058)
0.0	0.3	GO:0045746	negative regulation of Notch signaling pathway(GO:0045746)
0.0	0.0	GO:0019287	isopentenyl diphosphate biosynthetic process(GO:0009240) isopentenyl diphosphate biosynthetic process, mevalonate pathway(GO:0019287)
0.0	0.0	GO:0032747	positive regulation of interleukin-23 production(GO:0032747)
0.0	0.1	GO:0034116	positive regulation of heterotypic cell-cell adhesion(GO:0034116)
0.0	0.1	GO:1904668	positive regulation of ubiquitin protein ligase activity(GO:1904668)
0.0	0.1	GO:1900147	Schwann cell migration(GO:0036135) regulation of Schwann cell migration(GO:1900147)
0.0	0.1	GO:0033327	Leydig cell differentiation(GO:0033327)
0.0	0.0	GO:1903223	positive regulation of oxidative stress-induced neuron death(GO:1903223)
0.0	0.1	GO:0050872	white fat cell differentiation(GO:0050872)
0.0	0.0	GO:0021564	vagus nerve development(GO:0021564)
0.0	0.0	GO:0072674	multinuclear osteoclast differentiation(GO:0072674) osteoclast fusion(GO:0072675)
0.0	0.0	GO:1901475	pyruvate transmembrane transport(GO:1901475)
0.0	0.0	GO:2000562	negative regulation of CD4-positive, alpha-beta T cell proliferation(GO:2000562)
0.0	0.0	GO:0010792	DNA double-strand break processing involved in repair via single-strand annealing(GO:0010792)
0.0	0.1	GO:0021785	branchiomotor neuron axon guidance(GO:0021785)
0.0	0.1	GO:0030205	dermatan sulfate metabolic process(GO:0030205)
0.0	0.2	GO:0042572	retinol metabolic process(GO:0042572)
0.0	0.1	GO:0043162	ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043162)
0.0	0.1	GO:1901341	activation of store-operated calcium channel activity(GO:0032237) positive regulation of store-operated calcium channel activity(GO:1901341)
0.0	0.0	GO:0061366	behavioral response to chemical pain(GO:0061366) behavioral response to formalin induced pain(GO:0061368)
0.0	0.0	GO:0030718	germ-line stem cell population maintenance(GO:0030718)
0.0	0.0	GO:0008655	pyrimidine-containing compound salvage(GO:0008655) pyrimidine nucleoside salvage(GO:0043097)
0.0	0.1	GO:0080182	histone H3-K4 trimethylation(GO:0080182)
0.0	0.1	GO:0018026	peptidyl-lysine monomethylation(GO:0018026)
0.0	0.0	GO:0002125	maternal aggressive behavior(GO:0002125)
0.0	0.1	GO:0045717	negative regulation of fatty acid biosynthetic process(GO:0045717)
0.0	0.1	GO:0010898	positive regulation of triglyceride catabolic process(GO:0010898)
0.0	0.1	GO:0010457	centriole-centriole cohesion(GO:0010457)
0.0	0.1	GO:0061042	vascular wound healing(GO:0061042)
0.0	0.1	GO:0048597	post-embryonic camera-type eye morphogenesis(GO:0048597)
0.0	0.1	GO:0043504	mitochondrial DNA repair(GO:0043504)
0.0	0.1	GO:0090036	regulation of protein kinase C signaling(GO:0090036)
0.0	0.1	GO:0015722	canalicular bile acid transport(GO:0015722)
0.0	0.0	GO:0001712	ectodermal cell fate commitment(GO:0001712)
0.0	0.1	GO:0097120	receptor localization to synapse(GO:0097120)
0.0	0.0	GO:1904995	negative regulation of leukocyte tethering or rolling(GO:1903237) negative regulation of leukocyte adhesion to vascular endothelial cell(GO:1904995)
0.0	0.2	GO:0030322	stabilization of membrane potential(GO:0030322)
0.0	0.1	GO:0071318	cellular response to ATP(GO:0071318)
0.0	0.2	GO:0046856	phosphatidylinositol dephosphorylation(GO:0046856)
0.0	0.1	GO:0006670	sphingosine metabolic process(GO:0006670)
0.0	0.0	GO:0060061	Spemann organizer formation(GO:0060061)
0.0	0.0	GO:0032911	negative regulation of transforming growth factor beta1 production(GO:0032911)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:0032937	SREBP-SCAP-Insig complex(GO:0032937)
0.1	0.2	GO:0034365	discoidal high-density lipoprotein particle(GO:0034365)
0.1	0.2	GO:0005899	insulin receptor complex(GO:0005899)
0.1	0.2	GO:0097136	Bcl-2 family protein complex(GO:0097136)
0.0	0.4	GO:0043020	NADPH oxidase complex(GO:0043020)
0.0	0.3	GO:0008290	F-actin capping protein complex(GO:0008290)
0.0	0.1	GO:0035985	senescence-associated heterochromatin focus(GO:0035985)
0.0	0.3	GO:0005577	fibrinogen complex(GO:0005577)
0.0	0.1	GO:0030891	VCB complex(GO:0030891)
0.0	0.1	GO:0097443	sorting endosome(GO:0097443)
0.0	0.2	GO:0000138	Golgi trans cisterna(GO:0000138)
0.0	0.1	GO:0000214	tRNA-intron endonuclease complex(GO:0000214)
0.0	0.2	GO:0061700	GATOR2 complex(GO:0061700)
0.0	0.2	GO:0016012	sarcoglycan complex(GO:0016012)
0.0	0.1	GO:0000235	astral microtubule(GO:0000235)
0.0	0.1	GO:0002189	ribose phosphate diphosphokinase complex(GO:0002189)
0.0	0.4	GO:0001741	XY body(GO:0001741)
0.0	0.1	GO:0036488	CHOP-C/EBP complex(GO:0036488)
0.0	0.1	GO:0031313	extrinsic component of endosome membrane(GO:0031313)
0.0	0.3	GO:0071565	nBAF complex(GO:0071565)
0.0	0.1	GO:0036454	insulin-like growth factor binding protein complex(GO:0016942) growth factor complex(GO:0036454) insulin-like growth factor ternary complex(GO:0042567)
0.0	0.1	GO:0072487	MSL complex(GO:0072487)
0.0	0.1	GO:0031209	SCAR complex(GO:0031209)
0.0	0.1	GO:0071797	LUBAC complex(GO:0071797)
0.0	0.1	GO:0070847	core mediator complex(GO:0070847)
0.0	0.1	GO:0005751	mitochondrial respiratory chain complex IV(GO:0005751)
0.0	0.1	GO:0042613	MHC class II protein complex(GO:0042613)
0.0	0.2	GO:0005662	DNA replication factor A complex(GO:0005662)
0.0	0.0	GO:1990597	AIP1-IRE1 complex(GO:1990597)
0.0	0.2	GO:0005665	DNA-directed RNA polymerase II, core complex(GO:0005665)
0.0	0.2	GO:0031907	peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.0	0.1	GO:0001940	male pronucleus(GO:0001940)
0.0	0.0	GO:0000306	extrinsic component of vacuolar membrane(GO:0000306)
0.0	0.2	GO:0034385	very-low-density lipoprotein particle(GO:0034361) triglyceride-rich lipoprotein particle(GO:0034385)
0.0	0.1	GO:0042406	extrinsic component of endoplasmic reticulum membrane(GO:0042406)
0.0	0.1	GO:0032300	mismatch repair complex(GO:0032300)
0.0	0.2	GO:0000145	exocyst(GO:0000145)
0.0	0.0	GO:0097057	TRAF2-GSTP1 complex(GO:0097057)
0.0	0.3	GO:0016592	mediator complex(GO:0016592)
0.0	0.1	GO:0070578	RISC-loading complex(GO:0070578)
0.0	0.1	GO:0034364	high-density lipoprotein particle(GO:0034364)
0.0	0.3	GO:0030140	trans-Golgi network transport vesicle(GO:0030140)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	0.5	GO:0051718	DNA (cytosine-5-)-methyltransferase activity(GO:0003886) DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates(GO:0051718)
0.2	0.5	GO:0004611	phosphoenolpyruvate carboxykinase activity(GO:0004611)
0.1	0.3	GO:0016149	translation release factor activity, codon specific(GO:0016149)
0.1	0.4	GO:0047499	calcium-independent phospholipase A2 activity(GO:0047499)
0.1	0.4	GO:0016174	NAD(P)H oxidase activity(GO:0016174)
0.1	0.3	GO:0042609	CD4 receptor binding(GO:0042609)
0.1	0.3	GO:0005290	L-histidine transmembrane transporter activity(GO:0005290)
0.1	0.3	GO:0001665	alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity(GO:0001665)
0.1	0.2	GO:0004813	alanine-tRNA ligase activity(GO:0004813)
0.1	0.4	GO:0018641	3-(3-hydroxyphenyl)propionate hydroxylase activity(GO:0008688) 4-chlorobenzaldehyde oxidase activity(GO:0018471) 3,5-xylenol methylhydroxylase activity(GO:0018630) phenylacetate hydroxylase activity(GO:0018631) 4-nitrophenol 4-monooxygenase activity(GO:0018632) dimethyl sulfide monooxygenase activity(GO:0018633) alpha-pinene monooxygenase [NADH] activity(GO:0018634) 1-hydroxy-2-naphthoate hydroxylase activity(GO:0018637) toluene 4-monooxygenase activity(GO:0018638) xylene monooxygenase activity(GO:0018639) dibenzothiophene monooxygenase activity(GO:0018640) 6-hydroxy-3-methyl-2-oxo-1,2-dihydroquinoline 6-monooxygenase activity(GO:0018641) chlorophenol 4-monooxygenase activity(GO:0018642) carbon disulfide oxygenase activity(GO:0018643) toluene 2-monooxygenase activity(GO:0018644) 1-hydroxy-2-oxolimonene 1,2-monooxygenase activity(GO:0018646) phenanthrene 1,2-monooxygenase activity(GO:0018647) tetrahydrofuran hydroxylase activity(GO:0018649) styrene monooxygenase activity(GO:0018650) toluene-4-sulfonate monooxygenase activity(GO:0018651) toluene-sulfonate methyl-monooxygenase activity(GO:0018652) 3-methyl-2-oxo-1,2-dihydroquinoline 6-monooxygenase activity(GO:0018653) 2-hydroxy-phenylacetate hydroxylase activity(GO:0018654) 2-oxo-delta3-4,5,5-trimethylcyclopentenylacetyl-CoA 1,2-monooxygenase activity(GO:0018655) phenanthrene 3,4-monooxygenase activity(GO:0018656) toluene 3-monooxygenase activity(GO:0018657) 4-hydroxyphenylacetate,NADH:oxygen oxidoreductase (3-hydroxylating) activity(GO:0018660) limonene monooxygenase activity(GO:0019113) 2-methylnaphthalene hydroxylase activity(GO:0034526) 1-methylnaphthalene hydroxylase activity(GO:0034534) bisphenol A hydroxylase A activity(GO:0034560) salicylate 5-hydroxylase activity(GO:0034785) isobutylamine N-hydroxylase activity(GO:0034791) branched-chain dodecylbenzene sulfonate monooxygenase activity(GO:0034802) 3-HSA hydroxylase activity(GO:0034819) 4-hydroxypyridine-3-hydroxylase activity(GO:0034894) 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase activity(GO:0043719) 6-hydroxynicotinate 3-monooxygenase activity(GO:0043731) thalianol hydroxylase activity(GO:0080014)
0.1	0.1	GO:0032139	dinucleotide insertion or deletion binding(GO:0032139)
0.1	0.2	GO:0051434	BH3 domain binding(GO:0051434)
0.0	0.1	GO:0015222	serotonin transmembrane transporter activity(GO:0015222)
0.0	0.1	GO:0004069	L-aspartate:2-oxoglutarate aminotransferase activity(GO:0004069)
0.0	0.2	GO:0004652	polynucleotide adenylyltransferase activity(GO:0004652)
0.0	0.1	GO:0004605	phosphatidate cytidylyltransferase activity(GO:0004605)
0.0	0.2	GO:0000403	Y-form DNA binding(GO:0000403)
0.0	0.2	GO:0004459	L-lactate dehydrogenase activity(GO:0004459)
0.0	0.1	GO:0004793	threonine aldolase activity(GO:0004793) L-allo-threonine aldolase activity(GO:0008732)
0.0	0.7	GO:0001784	phosphotyrosine binding(GO:0001784)
0.0	0.1	GO:0071614	linoleic acid epoxygenase activity(GO:0071614)
0.0	0.1	GO:0003953	NAD+ nucleosidase activity(GO:0003953)
0.0	0.1	GO:0004594	pantothenate kinase activity(GO:0004594)
0.0	0.1	GO:0009378	four-way junction helicase activity(GO:0009378)
0.0	0.1	GO:0034714	type III transforming growth factor beta receptor binding(GO:0034714)
0.0	0.2	GO:0043237	laminin-1 binding(GO:0043237)
0.0	0.1	GO:0004427	inorganic diphosphatase activity(GO:0004427)
0.0	0.1	GO:0070698	type I activin receptor binding(GO:0070698)
0.0	0.1	GO:0051575	5'-deoxyribose-5-phosphate lyase activity(GO:0051575)
0.0	0.2	GO:0004439	phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity(GO:0004439)
0.0	0.1	GO:0004937	alpha1-adrenergic receptor activity(GO:0004937)
0.0	0.1	GO:0052622	4-hydroxybenzoate octaprenyltransferase activity(GO:0008412) protoheme IX farnesyltransferase activity(GO:0008495) (S)-2,3-di-O-geranylgeranylglyceryl phosphate synthase activity(GO:0043888) cadaverine aminopropyltransferase activity(GO:0043918) agmatine aminopropyltransferase activity(GO:0043919) 1,4-dihydroxy-2-naphthoate octaprenyltransferase activity(GO:0046428) trans-pentaprenyltranstransferase activity(GO:0048045) ATP dimethylallyltransferase activity(GO:0052622) ADP dimethylallyltransferase activity(GO:0052623)
0.0	0.2	GO:0001025	RNA polymerase III transcription factor binding(GO:0001025)
0.0	0.1	GO:0015137	citrate transmembrane transporter activity(GO:0015137) tricarboxylic acid transmembrane transporter activity(GO:0015142)
0.0	0.1	GO:0070728	leucine binding(GO:0070728)
0.0	0.1	GO:0000213	tRNA-intron endonuclease activity(GO:0000213)
0.0	0.1	GO:0004366	glycerol-3-phosphate O-acyltransferase activity(GO:0004366)
0.0	0.1	GO:0042015	interleukin-20 binding(GO:0042015)
0.0	0.2	GO:0019871	sodium channel inhibitor activity(GO:0019871)
0.0	0.1	GO:0055100	adiponectin binding(GO:0055100)
0.0	0.1	GO:0032422	purine-rich negative regulatory element binding(GO:0032422)
0.0	0.1	GO:0004720	protein-lysine 6-oxidase activity(GO:0004720)
0.0	0.1	GO:0004359	glutaminase activity(GO:0004359)
0.0	0.1	GO:0070579	methylcytosine dioxygenase activity(GO:0070579)
0.0	0.2	GO:0051400	BH domain binding(GO:0051400)
0.0	0.2	GO:0001609	G-protein coupled adenosine receptor activity(GO:0001609)
0.0	0.1	GO:0004749	ribose phosphate diphosphokinase activity(GO:0004749)
0.0	0.1	GO:0003985	acetyl-CoA C-acetyltransferase activity(GO:0003985) C-acetyltransferase activity(GO:0016453)
0.0	0.1	GO:0036310	annealing helicase activity(GO:0036310)
0.0	0.1	GO:0042392	sphingosine-1-phosphate phosphatase activity(GO:0042392)
0.0	0.2	GO:0016846	carbon-sulfur lyase activity(GO:0016846)
0.0	0.1	GO:0015349	thyroid hormone transmembrane transporter activity(GO:0015349)
0.0	0.1	GO:0004740	pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740)
0.0	0.1	GO:0004370	glycerol kinase activity(GO:0004370)
0.0	0.2	GO:0048406	nerve growth factor binding(GO:0048406)
0.0	0.1	GO:0004614	phosphoglucomutase activity(GO:0004614)
0.0	0.1	GO:0033142	progesterone receptor binding(GO:0033142)
0.0	0.1	GO:0043910	CTP:2,3-di-O-geranylgeranyl-sn-glycero-1-phosphate cytidyltransferase activity(GO:0043338) phospholactate guanylyltransferase activity(GO:0043814) ATP:coenzyme F420 adenylyltransferase activity(GO:0043910) UDP-N-acetylgalactosamine diphosphorylase activity(GO:0052630)
0.0	0.4	GO:0005035	tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.0	0.1	GO:0051377	mannose-ethanolamine phosphotransferase activity(GO:0051377)
0.0	0.1	GO:0005534	galactose binding(GO:0005534)
0.0	0.1	GO:0004046	aminoacylase activity(GO:0004046)
0.0	0.1	GO:0016833	oxo-acid-lyase activity(GO:0016833)
0.0	0.1	GO:0016841	ammonia-lyase activity(GO:0016841)
0.0	0.2	GO:0003854	3-beta-hydroxy-delta5-steroid dehydrogenase activity(GO:0003854)
0.0	0.1	GO:0051870	methotrexate binding(GO:0051870)
0.0	0.1	GO:0008321	Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.0	0.2	GO:0001222	transcription corepressor binding(GO:0001222)
0.0	0.1	GO:0004514	nicotinate-nucleotide diphosphorylase (carboxylating) activity(GO:0004514)
0.0	0.3	GO:0017049	GTP-Rho binding(GO:0017049)
0.0	0.1	GO:0004416	hydroxyacylglutathione hydrolase activity(GO:0004416)
0.0	0.2	GO:0008191	metalloendopeptidase inhibitor activity(GO:0008191)
0.0	0.1	GO:0004563	beta-N-acetylhexosaminidase activity(GO:0004563)
0.0	0.1	GO:0031432	titin binding(GO:0031432)
0.0	0.1	GO:0004924	oncostatin-M receptor activity(GO:0004924)
0.0	0.1	GO:0000774	adenyl-nucleotide exchange factor activity(GO:0000774)
0.0	0.1	GO:0004528	phosphodiesterase I activity(GO:0004528)
0.0	0.1	GO:0003873	6-phosphofructo-2-kinase activity(GO:0003873)
0.0	0.1	GO:0031995	insulin-like growth factor II binding(GO:0031995)
0.0	0.5	GO:0001105	RNA polymerase II transcription coactivator activity(GO:0001105)
0.0	0.1	GO:0047372	acylglycerol lipase activity(GO:0047372)
0.0	0.1	GO:0071558	histone demethylase activity (H3-K27 specific)(GO:0071558)
0.0	0.1	GO:0008440	inositol-1,4,5-trisphosphate 3-kinase activity(GO:0008440)
0.0	0.6	GO:0001102	RNA polymerase II activating transcription factor binding(GO:0001102)
0.0	0.1	GO:0033300	dehydroascorbic acid transporter activity(GO:0033300)
0.0	0.1	GO:0005021	vascular endothelial growth factor-activated receptor activity(GO:0005021)
0.0	0.2	GO:0016780	phosphotransferase activity, for other substituted phosphate groups(GO:0016780)
0.0	0.2	GO:0004185	serine-type carboxypeptidase activity(GO:0004185)
0.0	0.1	GO:0050700	CARD domain binding(GO:0050700)
0.0	0.2	GO:0042608	T cell receptor binding(GO:0042608)
0.0	0.1	GO:0004301	epoxide hydrolase activity(GO:0004301)
0.0	0.1	GO:0005078	MAP-kinase scaffold activity(GO:0005078)
0.0	0.0	GO:0004939	beta-adrenergic receptor activity(GO:0004939)
0.0	0.1	GO:0003917	DNA topoisomerase type I activity(GO:0003917)
0.0	0.0	GO:0008309	double-stranded DNA exodeoxyribonuclease activity(GO:0008309)
0.0	0.3	GO:0071889	14-3-3 protein binding(GO:0071889)
0.0	0.2	GO:0004711	ribosomal protein S6 kinase activity(GO:0004711)
0.0	0.1	GO:0016176	superoxide-generating NADPH oxidase activator activity(GO:0016176)
0.0	0.1	GO:0046912	transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
0.0	0.1	GO:0008113	peptide-methionine (S)-S-oxide reductase activity(GO:0008113)
0.0	0.3	GO:0008483	transaminase activity(GO:0008483)
0.0	0.0	GO:0008449	N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.0	0.2	GO:0035259	glucocorticoid receptor binding(GO:0035259)
0.0	0.1	GO:0008432	JUN kinase binding(GO:0008432)
0.0	0.1	GO:0052851	cupric reductase activity(GO:0008823) ferric-chelate reductase (NADPH) activity(GO:0052851)
0.0	0.1	GO:0004028	3-chloroallyl aldehyde dehydrogenase activity(GO:0004028)
0.0	0.1	GO:0070891	lipoteichoic acid binding(GO:0070891)
0.0	0.1	GO:0003906	DNA-(apurinic or apyrimidinic site) lyase activity(GO:0003906)
0.0	0.0	GO:0004999	vasoactive intestinal polypeptide receptor activity(GO:0004999)
0.0	0.0	GO:0071987	WD40-repeat domain binding(GO:0071987)
0.0	0.0	GO:0050816	phosphothreonine binding(GO:0050816)
0.0	0.1	GO:0000386	second spliceosomal transesterification activity(GO:0000386)
0.0	0.0	GO:0070139	ubiquitin-like protein-specific endopeptidase activity(GO:0070137) SUMO-specific endopeptidase activity(GO:0070139)
0.0	0.0	GO:0015018	galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity(GO:0015018)
0.0	0.6	GO:0043765	integrase activity(GO:0008907) T/G mismatch-specific endonuclease activity(GO:0043765) retroviral integrase activity(GO:0044823) retroviral 3' processing activity(GO:0044824)
0.0	0.0	GO:0050833	pyruvate transmembrane transporter activity(GO:0050833)
0.0	0.1	GO:0003996	acyl-CoA ligase activity(GO:0003996)
0.0	0.1	GO:0031559	oxidosqualene cyclase activity(GO:0031559)
0.0	0.1	GO:0004622	lysophospholipase activity(GO:0004622)
0.0	0.0	GO:0004849	uridine kinase activity(GO:0004849)
0.0	0.0	GO:0005148	prolactin receptor binding(GO:0005148)
0.0	0.0	GO:0008332	low voltage-gated calcium channel activity(GO:0008332)
0.0	0.0	GO:0005350	purine nucleobase transmembrane transporter activity(GO:0005345) pyrimidine nucleobase transmembrane transporter activity(GO:0005350) nucleobase transmembrane transporter activity(GO:0015205)
0.0	0.1	GO:0008390	testosterone 16-alpha-hydroxylase activity(GO:0008390)
0.0	0.0	GO:0015016	[heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.0	0.1	GO:0031957	very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.0	0.2	GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.0	0.1	GO:0031849	olfactory receptor binding(GO:0031849)
0.0	0.9	GO:0016423	tRNA (guanine) methyltransferase activity(GO:0016423)
0.0	0.1	GO:0046790	virion binding(GO:0046790)
0.0	0.0	GO:0070326	very-low-density lipoprotein particle receptor binding(GO:0070326)
0.0	0.2	GO:0022841	potassium ion leak channel activity(GO:0022841)
0.0	0.0	GO:0046573	lactonohydrolase activity(GO:0046573) acyl-L-homoserine-lactone lactonohydrolase activity(GO:0102007)
0.0	0.1	GO:0001134	transcription factor activity, transcription factor recruiting(GO:0001134)
0.0	0.0	GO:0004558	alpha-1,4-glucosidase activity(GO:0004558)
0.0	0.0	GO:0015057	thrombin receptor activity(GO:0015057)
0.0	0.1	GO:0035473	lipase binding(GO:0035473)

Gene overrepresentation in curated gene sets: canonical pathways category:

Total log-likelihood	Term	Description
0.4	PID VEGF VEGFR PATHWAY	VEGF and VEGFR signaling network
0.2	SA PROGRAMMED CELL DEATH	Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.3	PID HIF1A PATHWAY	Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.1	PID HDAC CLASSII PATHWAY	Signaling events mediated by HDAC Class II
0.2	PID ARF6 DOWNSTREAM PATHWAY	Arf6 downstream pathway
0.2	SA G1 AND S PHASES	Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
0.2	SA MMP CYTOKINE CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.4	PID INTEGRIN A4B1 PATHWAY	Alpha4 beta1 integrin signaling events
0.2	PID IL5 PATHWAY	IL5-mediated signaling events
0.2	PID EPHRINB REV PATHWAY	Ephrin B reverse signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.5	REACTOME ABACAVIR TRANSPORT AND METABOLISM	Genes involved in Abacavir transport and metabolism
0.0	0.1	REACTOME XENOBIOTICS	Genes involved in Xenobiotics
0.0	0.1	REACTOME ACYL CHAIN REMODELLING OF PG	Genes involved in Acyl chain remodelling of PG
0.0	0.2	REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION	Genes involved in APOBEC3G mediated resistance to HIV-1 infection
0.0	0.0	REACTOME RORA ACTIVATES CIRCADIAN EXPRESSION	Genes involved in RORA Activates Circadian Expression
0.0	0.2	REACTOME REGULATION OF THE FANCONI ANEMIA PATHWAY	Genes involved in Regulation of the Fanconi anemia pathway
0.0	0.4	REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION	Genes involved in Amino acid synthesis and interconversion (transamination)
0.0	0.3	REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA	Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.0	0.1	REACTOME RNA POL I PROMOTER OPENING	Genes involved in RNA Polymerase I Promoter Opening
0.0	0.4	REACTOME ACYL CHAIN REMODELLING OF PE	Genes involved in Acyl chain remodelling of PE
0.0	0.1	REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS	Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.0	0.3	REACTOME GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTERGRINS	Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins
0.0	0.4	REACTOME ERK MAPK TARGETS	Genes involved in ERK/MAPK targets
0.0	0.0	REACTOME NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE	Genes involved in NGF signalling via TRKA from the plasma membrane
0.0	0.3	REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA	Genes involved in Circadian Repression of Expression by REV-ERBA
0.0	0.8	REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION	Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.0	0.1	REACTOME RECEPTOR LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR	Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.0	0.1	REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS	Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.0	0.2	REACTOME VIRAL MESSENGER RNA SYNTHESIS	Genes involved in Viral Messenger RNA Synthesis
0.0	0.1	REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING	Genes involved in Downregulation of TGF-beta receptor signaling
0.0	0.1	REACTOME RECYCLING OF BILE ACIDS AND SALTS	Genes involved in Recycling of bile acids and salts
0.0	0.2	REACTOME CS DS DEGRADATION	Genes involved in CS/DS degradation
0.0	0.2	REACTOME PROCESSING OF INTRONLESS PRE MRNAS	Genes involved in Processing of Intronless Pre-mRNAs
0.0	0.1	REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS	Genes involved in Tandem pore domain potassium channels
0.0	0.2	REACTOME SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE	Genes involved in Synthesis of PIPs at the Golgi membrane
0.0	0.2	REACTOME CHOLESTEROL BIOSYNTHESIS	Genes involved in Cholesterol biosynthesis
0.0	0.1	REACTOME PURINE SALVAGE	Genes involved in Purine salvage
0.0	0.1	REACTOME AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL	Genes involved in AKT phosphorylates targets in the cytosol
0.0	0.2	REACTOME NUCLEOTIDE LIKE PURINERGIC RECEPTORS	Genes involved in Nucleotide-like (purinergic) receptors
0.0	0.0	REACTOME ALPHA LINOLENIC ACID ALA METABOLISM	Genes involved in alpha-linolenic acid (ALA) metabolism
0.0	0.1	REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY	Genes involved in TRAF3-dependent IRF activation pathway
0.0	0.1	REACTOME VEGF LIGAND RECEPTOR INTERACTIONS	Genes involved in VEGF ligand-receptor interactions
0.0	0.5	REACTOME INTERFERON ALPHA BETA SIGNALING	Genes involved in Interferon alpha/beta signaling
0.0	0.1	REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS	Genes involved in Signal regulatory protein (SIRP) family interactions