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ENCSR904DTN: DNase-seq of mouse liver in constant darkness

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for Xbp1_Creb3l1

Z-value: 1.06

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Transcription factors associated with Xbp1_Creb3l1

Gene Symbol	Gene ID	Gene Info
Xbp1 Ensembl NCBI MGI UniProt	ENSMUSG00000020484.12	Xbp1
Creb3l1 Ensembl NCBI MGI UniProt	ENSMUSG00000027230.9	Creb3l1

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

Gene	Promoter	Distance	Association probability	Pearson corr. coef.	P-value	Plot
Creb3l1	chr2_92008098_92008267	16320	0.133219	0.73	1.0e-01	Click!
Creb3l1	chr2_92004729_92004899	19688	0.126127	0.48	3.3e-01	Click!
Creb3l1	chr2_92008665_92009089	15625	0.134651	-0.28	5.9e-01	Click!
Creb3l1	chr2_92012868_92013034	11551	0.143118	-0.25	6.4e-01	Click!
Creb3l1	chr2_92027921_92028092	3504	0.191141	-0.21	6.9e-01	Click!
Xbp1	chr11_5529179_5529330	7331	0.131215	-0.72	1.1e-01	Click!
Xbp1	chr11_5528014_5528184	6176	0.135744	-0.67	1.5e-01	Click!
Xbp1	chr11_5523155_5523346	1327	0.335220	-0.62	1.9e-01	Click!
Xbp1	chr11_5521552_5521734	20	0.965863	0.58	2.3e-01	Click!
Xbp1	chr11_5526021_5526577	4376	0.149182	-0.53	2.8e-01	Click!

Activity of the Xbp1_Creb3l1 motif across conditions

Conditions sorted by the z-value of the Xbp1_Creb3l1 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr12_28899893_28900063	0.84	Gm31508	predicted gene, 31508	10251	0.18
chr11_119191869_119192119	0.80	Gm11753	predicted gene 11753	7478	0.13
chr6_118479189_118479349	0.76	Zfp9	zinc finger protein 9	51	0.97
chr3_84214395_84214574	0.73	Trim2	tripartite motif-containing 2	1646	0.43
chr11_86977739_86978000	0.72	Ypel2	yippee like 2	5845	0.19
chr1_157506654_157506814	0.69	Sec16b	SEC16 homolog B (S. cerevisiae)	6	0.97
chr17_50025214_50025398	0.59	AC133946.1	oxidoreductase NAD-binding domain containing 1 (OXNAD1) pseudogene	52479	0.12
chr15_86074327_86074478	0.58	Gramd4	GRAM domain containing 4	331	0.88
chr9_124125701_124125852	0.56	Ccr5	chemokine (C-C motif) receptor 5	908	0.61
chr6_128504617_128505108	0.52	Pzp	PZP, alpha-2-macroglobulin like	9639	0.09
chr13_93625401_93625555	0.51	Gm15622	predicted gene 15622	96	0.96
chr7_123196570_123196734	0.51	Tnrc6a	trinucleotide repeat containing 6a	16731	0.19
chr8_105289865_105290239	0.51	Gm20163	predicted gene, 20163	63	0.64
chr6_30563747_30563898	0.51	Cpa4	carboxypeptidase A4	4547	0.14
chrX_164036094_164036254	0.51	Car5b	carbonic anhydrase 5b, mitochondrial	8177	0.19
chr8_35432403_35432588	0.46	Gm34853	predicted gene, 34853	7239	0.18
chr2_30407337_30407488	0.44	Crat	carnitine acetyltransferase	733	0.48
chr12_8509811_8509989	0.42	5033421B08Rik	RIKEN cDNA 5033421B08 gene	1301	0.39
chr8_123718352_123718527	0.41	6030466F02Rik	RIKEN cDNA 6030466F02 gene	15519	0.07
chr7_4239400_4239603	0.40	Lilra5	leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 5	1747	0.21
chr4_123390896_123391047	0.40	Macf1	microtubule-actin crosslinking factor 1	433	0.8
chr11_119089692_119089843	0.40	Cbx4	chromobox 4	3546	0.18
chr2_172441299_172441621	0.40	Rtf2	replication termination factor 2	858	0.36
chr4_131837128_131837286	0.38	Ptpru	protein tyrosine phosphatase, receptor type, U	1024	0.44
chr5_8971094_8971245	0.37	Gm15610	predicted gene 15610	779	0.53
chr1_39192284_39192607	0.35	Npas2	neuronal PAS domain protein 2	1286	0.45
chr1_183369609_183369773	0.35	Mia3	melanoma inhibitory activity 3	138	0.92
chr5_144885994_144886193	0.34	Smurf1	SMAD specific E3 ubiquitin protein ligase 1	383	0.83
chr17_15192816_15193078	0.34	Gm35455	predicted gene, 35455	40788	0.13
chr16_45377470_45377621	0.34	Cd200	CD200 antigen	22767	0.16
chr5_113735843_113736024	0.34	Ficd	FIC domain containing	130	0.93
chr11_77793030_77793211	0.33	Gm10277	predicted gene 10277	5373	0.16
chr9_61816682_61816855	0.33	Gm19208	predicted gene, 19208	34936	0.17
chr9_57758758_57758995	0.33	Clk3	CDC-like kinase 3	3555	0.17
chr15_101299611_101299792	0.32	Smim41	small integral membrane protein 41	6469	0.1
chr18_75108255_75108425	0.32	Dym	dymeclin	6318	0.2
chr8_41179352_41179538	0.32	Fgl1	fibrinogen-like protein 1	35708	0.13
chr11_118454196_118454347	0.32	Gm11747	predicted gene 11747	724	0.56
chr8_70200077_70200228	0.30	Slc25a42	solute carrier family 25, member 42	12104	0.09
chr10_95408627_95408789	0.30	Socs2	suppressor of cytokine signaling 2	4026	0.16
chr13_54575762_54575922	0.29	Arl10	ADP-ribosylation factor-like 10	795	0.43
chr17_29496086_29496540	0.29	Pim1	proviral integration site 1	2906	0.15
chr2_59600868_59601029	0.29	Tanc1	tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1	11094	0.23
chr1_78568521_78568696	0.28	Mogat1	monoacylglycerol O-acyltransferase 1	30980	0.13
chr9_7571293_7571444	0.28	Mmp27	matrix metallopeptidase 27	28	0.97
chr11_115413035_115413484	0.28	Mrpl58	mitochondrial ribosomal protein L58	3099	0.1
chr10_85103610_85103858	0.27	Tmem263	transmembrane protein 263	991	0.4
chr2_6057072_6057245	0.27	Upf2	UPF2 regulator of nonsense transcripts homolog (yeast)	6731	0.22
chr12_86810853_86811037	0.27	Gm10095	predicted gene 10095	35522	0.14
chr12_17376956_17377119	0.27	Mir3066	microRNA 3066	21645	0.13
chr7_109562757_109562937	0.27	Denn2b	DENN domain containing 2B	22414	0.12
chr3_96645795_96645997	0.26	Itga10	integrin, alpha 10	312	0.73
chr14_51914351_51914597	0.26	Ndrg2	N-myc downstream regulated gene 2	316	0.76
chr5_66014048_66014243	0.26	9130230L23Rik	RIKEN cDNA 9130230L23 gene	9860	0.12
chr2_36082178_36082681	0.26	Lhx6	LIM homeobox protein 6	11844	0.12
chr12_80434710_80434908	0.26	Gm30025	predicted gene, 30025	400	0.74
chr4_108216816_108217079	0.26	Zyg11a	zyg-11 family member A, cell cycle regulator	975	0.5
chr5_144891376_144891550	0.25	Smurf1	SMAD specific E3 ubiquitin protein ligase 1	4987	0.17
chr12_21183267_21183628	0.25	AC156032.1		63876	0.08
chr9_63755131_63755299	0.25	Smad3	SMAD family member 3	2779	0.31
chr16_90856531_90856709	0.25	Gm36363	predicted gene, 36363	5657	0.14
chr16_95729140_95729334	0.25	Ets2	E26 avian leukemia oncogene 2, 3' domain	11503	0.18
chr5_113918817_113918980	0.25	Gm22056	predicted gene, 22056	9906	0.11
chr1_75661119_75661284	0.24	Gm5257	predicted gene 5257	24811	0.15
chr3_93520535_93520702	0.24	S100a11	S100 calcium binding protein A11	130	0.93
chr8_71366812_71367005	0.24	Use1	unconventional SNARE in the ER 1 homolog (S. cerevisiae)	34	0.95
chr5_114707898_114708063	0.23	Tchp	trichoplein, keratin filament binding	116	0.93
chr2_156462736_156462911	0.22	Gm14224	predicted gene 14224	7172	0.12
chr6_91117239_91117541	0.22	Nup210	nucleoporin 210	561	0.7
chr15_85645356_85645520	0.22	Gm49539	predicted gene, 49539	645	0.66
chr8_11727425_11727615	0.22	Arhgef7	Rho guanine nucleotide exchange factor (GEF7)	201	0.88
chr6_145306818_145306981	0.22	Gm44428	predicted gene, 44428	2589	0.17
chr4_144981227_144981590	0.22	Vps13d	vacuolar protein sorting 13D	2553	0.3
chr16_52249852_52250207	0.21	Alcam	activated leukocyte cell adhesion molecule	19032	0.27
chr19_43511661_43512096	0.21	Got1	glutamic-oxaloacetic transaminase 1, soluble	3987	0.15
chr10_53597848_53598018	0.21	Asf1a	anti-silencing function 1A histone chaperone	176	0.62
chr10_84381402_84381782	0.21	Nuak1	NUAK family, SNF1-like kinase, 1	10796	0.2
chr3_52708989_52709165	0.21	Gm22798	predicted gene, 22798	13678	0.2
chr1_36535791_36536054	0.21	Ankrd23	ankyrin repeat domain 23	183	0.87
chr19_8966562_8966728	0.21	Eef1g	eukaryotic translation elongation factor 1 gamma	396	0.66
chr3_27710416_27710593	0.21	Fndc3b	fibronectin type III domain containing 3B	65	0.98
chr10_84409024_84409261	0.20	Nuak1	NUAK family, SNF1-like kinase, 1	16754	0.17
chr2_168742510_168742664	0.20	Atp9a	ATPase, class II, type 9A	178	0.95
chr1_131975685_131975855	0.20	Slc45a3	solute carrier family 45, member 3	949	0.44
chr4_61439599_61439764	0.20	Mup15	major urinary protein 15	62	0.97
chr10_84803969_84804150	0.20	Gm24226	predicted gene, 24226	7124	0.23
chr3_153921648_153921917	0.20	Acadm	acyl-Coenzyme A dehydrogenase, medium chain	8360	0.09
chr4_135434067_135434419	0.20	Rcan3	regulator of calcineurin 3	390	0.72
chr2_104035717_104035881	0.20	Gm24644	predicted gene, 24644	4870	0.12
chr15_99847019_99847476	0.20	Lima1	LIM domain and actin binding 1	27104	0.07
chr9_47637935_47638086	0.20	Cadm1	cell adhesion molecule 1	107637	0.06
chr11_86807573_86807779	0.20	Dhx40	DEAH (Asp-Glu-Ala-His) box polypeptide 40	70	0.98
chr13_64153328_64153492	0.20	Zfp367	zinc finger protein 367	208	0.83
chr4_83221216_83221400	0.19	Ttc39b	tetratricopeptide repeat domain 39B	11862	0.19
chr4_61595719_61595883	0.19	Mup17	major urinary protein 17	70	0.97
chr19_3695153_3695350	0.19	Lrp5	low density lipoprotein receptor-related protein 5	8687	0.1
chr17_12371689_12371855	0.19	Plg	plasminogen	6836	0.16
chr7_44869987_44870160	0.19	Ptov1	prostate tumor over expressed gene 1	285	0.74
chr4_60139744_60139909	0.19	Mup2	major urinary protein 2	31	0.97
chr3_139205794_139206161	0.19	Stpg2	sperm tail PG rich repeat containing 2	84	0.98
chr11_17745312_17745477	0.19	Gm12016	predicted gene 12016	106211	0.07
chr13_94143352_94143530	0.19	Gm15907	predicted gene 15907	3324	0.24
chr1_171294216_171294434	0.18	Ufc1	ubiquitin-fold modifier conjugating enzyme 1	615	0.44
chr11_59428409_59428580	0.18	Snap47	synaptosomal-associated protein, 47	18997	0.1
chr6_55001492_55001666	0.18	Ggct	gamma-glutamyl cyclotransferase	8629	0.17
chr5_117245335_117245486	0.18	Taok3	TAO kinase 3	4950	0.16
chr4_61519388_61519546	0.18	Mup16	major urinary protein 16	0	0.98
chr4_153957077_153957238	0.18	A430005L14Rik	RIKEN cDNA A430005L14 gene	80	0.95
chr15_85036576_85036766	0.18	Fam118a	family with sequence similarity 118, member A	418	0.76
chr12_28910610_28910780	0.18	Gm31508	predicted gene, 31508	466	0.82
chr5_30231710_30232189	0.18	Selenoi	selenoprotein I	632	0.63
chr4_44991523_44991952	0.18	Grhpr	glyoxylate reductase/hydroxypyruvate reductase	10237	0.11
chr7_45139988_45140693	0.18	Flt3l	FMS-like tyrosine kinase 3 ligand	3908	0.05
chr17_74716795_74716985	0.18	Ttc27	tetratricopeptide repeat domain 27	842	0.65
chr12_105297953_105298115	0.18	Tunar	Tcl1 upstream neural differentiation associated RNA	35836	0.14
chr8_127295141_127295294	0.18	Pard3	par-3 family cell polarity regulator	4368	0.35
chr18_34331012_34331178	0.18	Srp19	signal recognition particle 19	28	0.98
chr8_33987157_33987321	0.18	Gm45817	predicted gene 45817	39	0.96
chr18_61489282_61489444	0.17	Gm46637	predicted gene, 46637	4597	0.14
chr5_74943885_74944036	0.17	Gm6116	predicted gene 6116	5230	0.2
chr4_60662258_60662429	0.17	Mup11	major urinary protein 11	15	0.97
chr19_5770906_5771201	0.17	Scyl1	SCY1-like 1 (S. cerevisiae)	106	0.91
chr11_58093075_58093271	0.17	Gm12248	predicted gene 12248	39	0.96
chr1_133278743_133278947	0.17	Plekha6	pleckstrin homology domain containing, family A member 6	4591	0.15
chr16_97418050_97418216	0.17	Bace2	beta-site APP-cleaving enzyme 2	3055	0.21
chr5_66074323_66074506	0.17	Gm43775	predicted gene 43775	1519	0.29
chr17_28930275_28930478	0.17	Gm16191	predicted gene 16191	4045	0.1
chr4_137468313_137468498	0.17	Hspg2	perlecan (heparan sulfate proteoglycan 2)	364	0.81
chr2_127506298_127506464	0.17	AL731831.1	prominin 2 (Prom2), pseudogene	12914	0.13
chr10_128980928_128981107	0.17	Olfr9	olfactory receptor 9	8414	0.09
chr11_21428880_21429060	0.17	Gm12044	predicted gene 12044	22384	0.14
chr1_38864480_38864651	0.16	Chst10	carbohydrate sulfotransferase 10	7195	0.16
chr19_46133855_46134398	0.16	Elovl3	elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 3	2229	0.19
chr12_4039052_4039225	0.16	Efr3b	EFR3 homolog B	223	0.92
chr9_73039846_73040053	0.16	Pigbos1	Pigb opposite strand 1	219	0.5
chr7_27331182_27331346	0.16	Ltbp4	latent transforming growth factor beta binding protein 4	2349	0.17
chr14_77343821_77343990	0.16	Gm49001	predicted gene, 49001	281	0.93
chr4_60070204_60070385	0.16	Mup7	major urinary protein 7	117	0.96
chr12_79684888_79685267	0.16	9430078K24Rik	RIKEN cDNA 9430078K24 gene	239656	0.02
chr7_44999841_45000005	0.16	Irf3	interferon regulatory factor 3	244	0.73
chr2_168127857_168128015	0.16	AL831766.1	breast carcinoma amplified sequence 4 (BCAS4) pseudogene	13059	0.12
chr13_12454823_12454987	0.16	Lgals8	lectin, galactose binding, soluble 8	109	0.96
chr2_148040189_148040578	0.16	9030622O22Rik	RIKEN cDNA 9030622O22 gene	180	0.94
chr14_17683673_17683824	0.16	Thrb	thyroid hormone receptor beta	22852	0.26
chr2_156732212_156732375	0.16	Dlgap4	DLG associated protein 4	10801	0.13
chr2_45253993_45254149	0.16	Gm13475	predicted gene 13475	75161	0.1
chr3_27686853_27687185	0.16	Fndc3b	fibronectin type III domain containing 3B	23379	0.24
chr5_9047464_9048021	0.16	Gm40264	predicted gene, 40264	12618	0.15
chr4_60222408_60222586	0.16	Mup8	major urinary protein 8	83	0.97
chr6_12466411_12466591	0.16	Thsd7a	thrombospondin, type I, domain containing 7A	47140	0.18
chr16_4753759_4754349	0.16	Hmox2	heme oxygenase 2	2791	0.17
chr6_5190649_5191077	0.16	Pon1	paraoxonase 1	2900	0.26
chr15_88894079_88894230	0.16	Gm20621	predicted gene 20621	2629	0.2
chr8_70594556_70594707	0.16	Isyna1	myo-inositol 1-phosphate synthase A1	96	0.93
chr1_152556824_152557014	0.15	Rgl1	ral guanine nucleotide dissociation stimulator,-like 1	3875	0.31
chr10_99615923_99616079	0.15	Gm20110	predicted gene, 20110	6830	0.19
chr16_50430297_50430475	0.15	Bbx	bobby sox HMG box containing	474	0.88
chr7_16924149_16924320	0.15	Calm3	calmodulin 3	120	0.92
chr5_138979896_138980396	0.15	Pdgfa	platelet derived growth factor, alpha	14135	0.17
chr4_60501802_60501955	0.15	Mup1	major urinary protein 1	25	0.94
chr4_32520693_32520870	0.15	Bach2	BTB and CNC homology, basic leucine zipper transcription factor 2	19276	0.19
chr4_116685113_116685395	0.15	Prdx1	peroxiredoxin 1	290	0.83
chr5_129501132_129501293	0.15	Sfswap	splicing factor SWAP	9	0.74
chr6_121329980_121330165	0.15	Gm24855	predicted gene, 24855	4396	0.17
chr5_45476407_45476609	0.15	Lap3	leucine aminopeptidase 3	16866	0.11
chr8_3631331_3631522	0.15	Stxbp2	syntaxin binding protein 2	256	0.79
chr5_116453577_116453751	0.15	Srrm4	serine/arginine repetitive matrix 4	249	0.88
chr2_109978777_109979106	0.15	Lgr4	leucine-rich repeat-containing G protein-coupled receptor 4	3399	0.26
chr8_10899998_10900419	0.15	4833411C07Rik	RIKEN cDNA 4833411C07 gene	271	0.54
chr6_28480072_28480271	0.15	Snd1	staphylococcal nuclease and tudor domain containing 1	177	0.93
chr8_27174337_27174510	0.15	Rab11fip1	RAB11 family interacting protein 1 (class I)	204	0.88
chr9_69289046_69289527	0.15	Rora	RAR-related orphan receptor alpha	396	0.89
chr9_111211971_111212321	0.15	Lrrfip2	leucine rich repeat (in FLII) interacting protein 2	2047	0.3
chr8_77098217_77098409	0.15	Nr3c2	nuclear receptor subfamily 3, group C, member 2	29700	0.19
chr10_59504215_59504400	0.15	Mcu	mitochondrial calcium uniporter	46147	0.13
chr9_61596903_61597054	0.15	Gm34424	predicted gene, 34424	63563	0.12
chr10_13967469_13967637	0.15	Hivep2	human immunodeficiency virus type I enhancer binding protein 2	529	0.78
chr16_92415881_92416059	0.15	Rcan1	regulator of calcineurin 1	15893	0.13
chr3_31122977_31123199	0.14	Skil	SKI-like	26255	0.16
chr11_83834151_83834516	0.14	Gm12576	predicted gene 12576	15160	0.12
chr4_118137948_118138112	0.14	St3gal3	ST3 beta-galactoside alpha-2,3-sialyltransferase 3	3116	0.21
chr1_133452688_133453146	0.14	Sox13	SRY (sex determining region Y)-box 13	28540	0.16
chr7_30360114_30360296	0.14	Lrfn3	leucine rich repeat and fibronectin type III domain containing 3	2567	0.1
chr19_43512283_43512443	0.14	Got1	glutamic-oxaloacetic transaminase 1, soluble	3502	0.15
chr10_18056009_18056160	0.14	Reps1	RalBP1 associated Eps domain containing protein	80	0.97
chr14_122104924_122105095	0.14	A330035P11Rik	RIKEN cDNA A330035P11 gene	1944	0.21
chr16_21646037_21646193	0.14	Vps8	VPS8 CORVET complex subunit	18484	0.2
chr4_53023825_53023983	0.14	Nipsnap3b	nipsnap homolog 3B	2928	0.22
chr11_19992826_19993027	0.14	Spred2	sprouty-related EVH1 domain containing 2	38356	0.18
chr7_73574787_73575110	0.14	1810026B05Rik	RIKEN cDNA 1810026B05 gene	16553	0.1
chr4_118158547_118158710	0.14	Kdm4a	lysine (K)-specific demethylase 4A	3029	0.2
chr7_100042239_100042447	0.14	Chrdl2	chordin-like 2	20244	0.14
chr2_150786904_150787055	0.14	Pygb	brain glycogen phosphorylase	244	0.91
chr5_112893601_112893976	0.14	Myo18b	myosin XVIIIb	2574	0.29
chr6_121841280_121841702	0.14	Mug1	murinoglobulin 1	387	0.88
chr18_12213171_12213322	0.14	Npc1	NPC intracellular cholesterol transporter 1	692	0.62
chr9_103471973_103472146	0.14	Gm16252	predicted gene 16252	25	0.96
chr3_83032424_83032575	0.14	Fga	fibrinogen alpha chain	6284	0.15
chr1_183367200_183367450	0.14	Mia3	melanoma inhibitory activity 3	2228	0.21
chr5_139499620_139499800	0.14	Zfand2a	zinc finger, AN1-type domain 2A	15161	0.13

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of Xbp1_Creb3l1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	0.7	GO:0048208	vesicle targeting, rough ER to cis-Golgi(GO:0048207) COPII vesicle coating(GO:0048208)
0.1	0.3	GO:0052042	induction of programmed cell death(GO:0012502) positive regulation of apoptotic process in other organism(GO:0044533) positive regulation by symbiont of host programmed cell death(GO:0052042) positive regulation by symbiont of host apoptotic process(GO:0052151) positive regulation by organism of programmed cell death in other organism involved in symbiotic interaction(GO:0052330) positive regulation by organism of apoptotic process in other organism involved in symbiotic interaction(GO:0052501) positive regulation of apoptotic process by virus(GO:0060139)
0.1	0.4	GO:1902534	single-organism membrane invagination(GO:1902534)
0.1	0.2	GO:0019254	carnitine metabolic process, CoA-linked(GO:0019254)
0.1	0.2	GO:0090360	platelet-derived growth factor production(GO:0090360) regulation of platelet-derived growth factor production(GO:0090361)
0.0	0.1	GO:0097296	activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:0097296)
0.0	0.1	GO:0036216	response to stem cell factor(GO:0036215) cellular response to stem cell factor stimulus(GO:0036216) Kit signaling pathway(GO:0038109)
0.0	0.2	GO:1990564	protein polyufmylation(GO:1990564) protein K69-linked ufmylation(GO:1990592)
0.0	0.2	GO:0002317	plasma cell differentiation(GO:0002317)
0.0	0.1	GO:0060397	JAK-STAT cascade involved in growth hormone signaling pathway(GO:0060397)
0.0	0.3	GO:0006620	posttranslational protein targeting to membrane(GO:0006620)
0.0	0.3	GO:0043615	astrocyte cell migration(GO:0043615)
0.0	0.2	GO:0060510	Type II pneumocyte differentiation(GO:0060510)
0.0	0.1	GO:0015772	disaccharide transport(GO:0015766) sucrose transport(GO:0015770) oligosaccharide transport(GO:0015772)
0.0	0.1	GO:0070164	negative regulation of adiponectin secretion(GO:0070164)
0.0	0.1	GO:2000189	positive regulation of cholesterol homeostasis(GO:2000189)
0.0	0.1	GO:0050689	negative regulation of defense response to virus by host(GO:0050689)
0.0	0.1	GO:0002071	glandular epithelial cell maturation(GO:0002071)
0.0	0.1	GO:0010735	positive regulation of transcription via serum response element binding(GO:0010735)
0.0	0.1	GO:2001286	regulation of caveolin-mediated endocytosis(GO:2001286)
0.0	0.2	GO:1902018	negative regulation of cilium assembly(GO:1902018)
0.0	0.1	GO:0045472	response to ether(GO:0045472)
0.0	0.2	GO:0051775	response to redox state(GO:0051775)
0.0	0.1	GO:0030070	insulin processing(GO:0030070)
0.0	0.3	GO:0051895	negative regulation of focal adhesion assembly(GO:0051895)
0.0	0.2	GO:1904153	negative regulation of protein exit from endoplasmic reticulum(GO:0070862) negative regulation of retrograde protein transport, ER to cytosol(GO:1904153)
0.0	0.1	GO:0000395	mRNA 5'-splice site recognition(GO:0000395)
0.0	0.0	GO:0046066	purine deoxyribonucleoside diphosphate metabolic process(GO:0009182) dGDP metabolic process(GO:0046066)
0.0	0.1	GO:0003383	apical constriction(GO:0003383)
0.0	0.1	GO:0007525	somatic muscle development(GO:0007525)
0.0	0.0	GO:0043309	regulation of eosinophil degranulation(GO:0043309)
0.0	0.1	GO:0015884	folic acid transport(GO:0015884)
0.0	0.1	GO:0042726	flavin-containing compound metabolic process(GO:0042726)
0.0	0.2	GO:0060297	regulation of sarcomere organization(GO:0060297)
0.0	0.1	GO:0043152	induction of bacterial agglutination(GO:0043152)
0.0	0.1	GO:0032264	IMP salvage(GO:0032264)
0.0	0.0	GO:0002278	eosinophil activation involved in immune response(GO:0002278) eosinophil mediated immunity(GO:0002447) eosinophil degranulation(GO:0043308)
0.0	0.1	GO:0072282	metanephric nephron tubule morphogenesis(GO:0072282)
0.0	0.1	GO:0019482	beta-alanine metabolic process(GO:0019482)
0.0	0.0	GO:1903598	positive regulation of gap junction assembly(GO:1903598)
0.0	0.1	GO:0007089	traversing start control point of mitotic cell cycle(GO:0007089)
0.0	0.1	GO:0061428	negative regulation of transcription from RNA polymerase II promoter in response to hypoxia(GO:0061428)
0.0	0.1	GO:0051791	medium-chain fatty acid metabolic process(GO:0051791)
0.0	0.1	GO:0045053	protein retention in Golgi apparatus(GO:0045053)
0.0	0.0	GO:0019371	cyclooxygenase pathway(GO:0019371)
0.0	0.1	GO:0019401	alditol biosynthetic process(GO:0019401)
0.0	0.1	GO:0001712	ectodermal cell fate commitment(GO:0001712)
0.0	0.1	GO:0042985	negative regulation of amyloid precursor protein biosynthetic process(GO:0042985)
0.0	0.0	GO:0036066	protein O-linked fucosylation(GO:0036066)
0.0	0.0	GO:1901069	guanosine-containing compound catabolic process(GO:1901069)
0.0	0.0	GO:0008050	female courtship behavior(GO:0008050)
0.0	0.1	GO:0006020	inositol metabolic process(GO:0006020)
0.0	0.1	GO:0042256	mature ribosome assembly(GO:0042256)
0.0	0.0	GO:0061623	galactose catabolic process via UDP-galactose(GO:0033499) glycolytic process from galactose(GO:0061623)
0.0	0.1	GO:0008355	olfactory learning(GO:0008355)
0.0	0.1	GO:0042997	negative regulation of Golgi to plasma membrane protein transport(GO:0042997)
0.0	0.1	GO:2000188	regulation of cholesterol homeostasis(GO:2000188)
0.0	0.0	GO:0035434	copper ion transmembrane transport(GO:0035434)
0.0	0.1	GO:0060978	angiogenesis involved in coronary vascular morphogenesis(GO:0060978)
0.0	0.1	GO:0035469	determination of pancreatic left/right asymmetry(GO:0035469)
0.0	0.0	GO:0003032	detection of oxygen(GO:0003032)
0.0	0.0	GO:1902065	response to L-glutamate(GO:1902065)
0.0	0.1	GO:0030259	lipid glycosylation(GO:0030259)
0.0	0.1	GO:0045838	positive regulation of membrane potential(GO:0045838)
0.0	0.0	GO:0045218	zonula adherens maintenance(GO:0045218)
0.0	0.2	GO:0046854	phosphatidylinositol phosphorylation(GO:0046854)
0.0	0.3	GO:0002063	chondrocyte development(GO:0002063)
0.0	0.1	GO:0009186	deoxyribonucleoside diphosphate metabolic process(GO:0009186)
0.0	0.0	GO:2000591	positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway(GO:0035793) regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway(GO:1900238) positive regulation of metanephric mesenchymal cell migration(GO:2000591)
0.0	0.1	GO:0006572	tyrosine catabolic process(GO:0006572)
0.0	0.1	GO:0033523	histone H2B ubiquitination(GO:0033523)
0.0	0.0	GO:0042524	negative regulation of tyrosine phosphorylation of Stat5 protein(GO:0042524)
0.0	0.0	GO:0002019	regulation of renal output by angiotensin(GO:0002019)
0.0	0.0	GO:0019464	glycine catabolic process(GO:0006546) glycine decarboxylation via glycine cleavage system(GO:0019464)
0.0	0.0	GO:0097461	ferric iron import(GO:0033216) ferric iron import into cell(GO:0097461)
0.0	0.1	GO:0017014	protein nitrosylation(GO:0017014)
0.0	0.0	GO:0000715	nucleotide-excision repair, DNA damage recognition(GO:0000715)
0.0	0.1	GO:0060267	positive regulation of respiratory burst(GO:0060267)
0.0	0.0	GO:0009080	alanine catabolic process(GO:0006524) pyruvate family amino acid catabolic process(GO:0009080)
0.0	0.0	GO:0018894	dibenzo-p-dioxin metabolic process(GO:0018894)
0.0	0.2	GO:0005980	glycogen catabolic process(GO:0005980) glucan catabolic process(GO:0009251) cellular polysaccharide catabolic process(GO:0044247)
0.0	0.0	GO:0051790	short-chain fatty acid biosynthetic process(GO:0051790)
0.0	0.1	GO:0071786	endoplasmic reticulum tubular network organization(GO:0071786)
0.0	0.1	GO:0048194	Golgi vesicle budding(GO:0048194)
0.0	0.0	GO:0016554	cytidine to uridine editing(GO:0016554)
0.0	0.0	GO:1900211	mesenchymal cell apoptotic process involved in metanephros development(GO:1900200) regulation of mesenchymal cell apoptotic process involved in metanephros development(GO:1900211) negative regulation of mesenchymal cell apoptotic process involved in metanephros development(GO:1900212)
0.0	0.0	GO:0036444	calcium ion transmembrane import into mitochondrion(GO:0036444)
0.0	0.0	GO:0006651	diacylglycerol biosynthetic process(GO:0006651)
0.0	0.1	GO:0006335	DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.0	0.1	GO:0015722	canalicular bile acid transport(GO:0015722)
0.0	0.1	GO:0006526	arginine biosynthetic process(GO:0006526)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.2	GO:0000322	storage vacuole(GO:0000322)
0.0	0.2	GO:0042406	extrinsic component of endoplasmic reticulum membrane(GO:0042406)
0.0	0.1	GO:0044352	pinosome(GO:0044352) macropinosome(GO:0044354)
0.0	0.1	GO:0071141	SMAD protein complex(GO:0071141)
0.0	0.2	GO:0045179	apical cortex(GO:0045179)
0.0	0.1	GO:0033269	internode region of axon(GO:0033269)
0.0	0.1	GO:0005786	signal recognition particle, endoplasmic reticulum targeting(GO:0005786) signal recognition particle(GO:0048500)
0.0	0.1	GO:0005971	ribonucleoside-diphosphate reductase complex(GO:0005971)
0.0	0.1	GO:0070820	tertiary granule(GO:0070820)
0.0	0.2	GO:0016442	RISC complex(GO:0016442) RNAi effector complex(GO:0031332)
0.0	0.1	GO:0016593	Cdc73/Paf1 complex(GO:0016593)
0.0	0.2	GO:0035102	PRC1 complex(GO:0035102)
0.0	0.0	GO:0000110	nucleotide-excision repair factor 1 complex(GO:0000110)
0.0	0.1	GO:0030121	AP-1 adaptor complex(GO:0030121)
0.0	0.1	GO:0071439	clathrin complex(GO:0071439)
0.0	0.1	GO:0000243	commitment complex(GO:0000243)
0.0	0.1	GO:0031462	Cul2-RING ubiquitin ligase complex(GO:0031462)
0.0	0.1	GO:0005577	fibrinogen complex(GO:0005577)
0.0	0.1	GO:0033010	paranodal junction(GO:0033010)
0.0	0.1	GO:0034098	VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.2	GO:0008597	calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597)
0.1	0.4	GO:0019957	C-C chemokine binding(GO:0019957)
0.0	0.1	GO:0031800	type 3 metabotropic glutamate receptor binding(GO:0031800)
0.0	0.1	GO:0008184	glycogen phosphorylase activity(GO:0008184)
0.0	0.4	GO:0070411	I-SMAD binding(GO:0070411)
0.0	0.2	GO:0098639	collagen binding involved in cell-matrix adhesion(GO:0098639)
0.0	0.1	GO:0008142	oxysterol binding(GO:0008142)
0.0	0.1	GO:0005072	transforming growth factor beta receptor, cytoplasmic mediator activity(GO:0005072)
0.0	0.1	GO:0008506	sucrose:proton symporter activity(GO:0008506) sucrose transmembrane transporter activity(GO:0008515) disaccharide transmembrane transporter activity(GO:0015154) oligosaccharide transmembrane transporter activity(GO:0015157)
0.0	0.1	GO:0008379	thioredoxin peroxidase activity(GO:0008379)
0.0	0.1	GO:0008312	7S RNA binding(GO:0008312)
0.0	0.1	GO:0005131	growth hormone receptor binding(GO:0005131)
0.0	0.1	GO:0003876	AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.0	0.1	GO:0070644	vitamin D response element binding(GO:0070644)
0.0	0.1	GO:0050815	phosphoserine binding(GO:0050815)
0.0	0.1	GO:0045134	uridine-diphosphatase activity(GO:0045134)
0.0	0.1	GO:0019871	sodium channel inhibitor activity(GO:0019871)
0.0	0.1	GO:0046573	lactonohydrolase activity(GO:0046573) acyl-L-homoserine-lactone lactonohydrolase activity(GO:0102007)
0.0	0.1	GO:0008321	Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.0	0.1	GO:0019166	trans-2-enoyl-CoA reductase (NADPH) activity(GO:0019166)
0.0	0.1	GO:0061731	ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.0	0.1	GO:0080130	L-phenylalanine:2-oxoglutarate aminotransferase activity(GO:0080130)
0.0	0.1	GO:0097109	neuroligin family protein binding(GO:0097109)
0.0	0.2	GO:0031432	titin binding(GO:0031432)
0.0	0.1	GO:0034186	apolipoprotein A-I binding(GO:0034186)
0.0	0.0	GO:0046404	ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity(GO:0046404) polydeoxyribonucleotide kinase activity(GO:0051733)
0.0	0.1	GO:1904288	BAT3 complex binding(GO:1904288)
0.0	0.1	GO:0031730	CCR5 chemokine receptor binding(GO:0031730)
0.0	0.0	GO:0004731	purine-nucleoside phosphorylase activity(GO:0004731)
0.0	0.0	GO:0070905	serine binding(GO:0070905)
0.0	0.1	GO:0008430	selenium binding(GO:0008430)
0.0	0.1	GO:0008517	folic acid transporter activity(GO:0008517)
0.0	0.2	GO:0004012	phospholipid-translocating ATPase activity(GO:0004012)
0.0	0.1	GO:0003836	beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.0	0.1	GO:0035613	RNA stem-loop binding(GO:0035613)
0.0	0.1	GO:0070191	methionine-R-sulfoxide reductase activity(GO:0070191)
0.0	0.0	GO:0005173	stem cell factor receptor binding(GO:0005173)
0.0	0.0	GO:0004165	dodecenoyl-CoA delta-isomerase activity(GO:0004165)
0.0	0.2	GO:0005186	pheromone activity(GO:0005186)
0.0	0.0	GO:0008823	cupric reductase activity(GO:0008823) ferric-chelate reductase (NADPH) activity(GO:0052851)
0.0	0.2	GO:0019789	SUMO transferase activity(GO:0019789)
0.0	0.0	GO:0072542	protein phosphatase activator activity(GO:0072542)
0.0	0.0	GO:0004144	diacylglycerol O-acyltransferase activity(GO:0004144)
0.0	0.1	GO:0005092	GDP-dissociation inhibitor activity(GO:0005092)

Gene overrepresentation in curated gene sets: canonical pathways category:

Total log-likelihood	Term	Description
0.4	ST STAT3 PATHWAY	STAT3 Pathway
0.7	PID TGFBR PATHWAY	TGF-beta receptor signaling
0.1	PID IL2 1PATHWAY	IL2-mediated signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	REACTOME BINDING AND ENTRY OF HIV VIRION	Genes involved in Binding and entry of HIV virion
0.0	0.5	REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION	Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.0	0.2	REACTOME IL 6 SIGNALING	Genes involved in Interleukin-6 signaling
0.0	0.4	REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA	Genes involved in Circadian Repression of Expression by REV-ERBA
0.0	0.1	REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION	Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.0	0.2	REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS	Genes involved in Glycogen breakdown (glycogenolysis)
0.0	0.1	REACTOME PURINE CATABOLISM	Genes involved in Purine catabolism
0.0	0.0	REACTOME XENOBIOTICS	Genes involved in Xenobiotics
0.0	0.1	REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY	Genes involved in TRAF3-dependent IRF activation pathway
0.0	0.2	REACTOME PEROXISOMAL LIPID METABOLISM	Genes involved in Peroxisomal lipid metabolism