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ENCSR904DTN: DNase-seq of mouse liver in constant darkness
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Results for Xbp1_Creb3l1

Z-value: 1.06

Motif logo

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Transcription factors associated with Xbp1_Creb3l1

Gene Symbol Gene ID Gene Info
Xbp1
ENSMUSG00000020484.12 X-box binding protein 1
Creb3l1
ENSMUSG00000027230.9 cAMP responsive element binding protein 3-like 1

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE Gene Distance Association probability Pearson corr. coef. P-value Plot
chr2_92008098_92008267Creb3l1163200.1332190.731.0e-01Click!
chr2_92004729_92004899Creb3l1196880.1261270.483.3e-01Click!
chr2_92008665_92009089Creb3l1156250.134651-0.285.9e-01Click!
chr2_92012868_92013034Creb3l1115510.143118-0.256.4e-01Click!
chr2_92027921_92028092Creb3l135040.191141-0.216.9e-01Click!
chr11_5529179_5529330Xbp173310.131215-0.721.1e-01Click!
chr11_5528014_5528184Xbp161760.135744-0.671.5e-01Click!
chr11_5523155_5523346Xbp113270.335220-0.621.9e-01Click!
chr11_5521552_5521734Xbp1200.9658630.582.3e-01Click!
chr11_5526021_5526577Xbp143760.149182-0.532.8e-01Click!

Activity of the Xbp1_Creb3l1 motif across conditions

Conditions sorted by the z-value of the Xbp1_Creb3l1 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE) Target Score Top associated gene Gene Info Distance of CRE to TSS CRE/Gene association probability
chr12_28899893_28900063 0.84 Gm31508
 predicted gene, 31508
 10251
 0.18
chr11_119191869_119192119 0.80 Gm11753
 predicted gene 11753
 7478
 0.13
chr6_118479189_118479349 0.76 Zfp9
 zinc finger protein 9
 51
 0.97
chr3_84214395_84214574 0.73 Trim2
 tripartite motif-containing 2
 1646
 0.43
chr11_86977739_86978000 0.72 Ypel2
 yippee like 2
 5845
 0.19
chr1_157506654_157506814 0.69 Sec16b
 SEC16 homolog B (S. cerevisiae)
 6
 0.97
chr17_50025214_50025398 0.59 AC133946.1
 oxidoreductase NAD-binding domain containing 1 (OXNAD1) pseudogene
 52479
 0.12
chr15_86074327_86074478 0.58 Gramd4
 GRAM domain containing 4
 331
 0.88
chr9_124125701_124125852 0.56 Ccr5
 chemokine (C-C motif) receptor 5
 908
 0.61
chr6_128504617_128505108 0.52 Pzp
 PZP, alpha-2-macroglobulin like
 9639
 0.09
chr13_93625401_93625555 0.51 Gm15622
 predicted gene 15622
 96
 0.96
chr7_123196570_123196734 0.51 Tnrc6a
 trinucleotide repeat containing 6a
 16731
 0.19
chr8_105289865_105290239 0.51 Gm20163
 predicted gene, 20163
 63
 0.64
chr6_30563747_30563898 0.51 Cpa4
 carboxypeptidase A4
 4547
 0.14
chrX_164036094_164036254 0.51 Car5b
 carbonic anhydrase 5b, mitochondrial
 8177
 0.19
chr8_35432403_35432588 0.46 Gm34853
 predicted gene, 34853
 7239
 0.18
chr2_30407337_30407488 0.44 Crat
 carnitine acetyltransferase
 733
 0.48
chr12_8509811_8509989 0.42 5033421B08Rik
 RIKEN cDNA 5033421B08 gene
 1301
 0.39
chr8_123718352_123718527 0.41 6030466F02Rik
 RIKEN cDNA 6030466F02 gene
 15519
 0.07
chr7_4239400_4239603 0.40 Lilra5
 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 5
 1747
 0.21
chr4_123390896_123391047 0.40 Macf1
 microtubule-actin crosslinking factor 1
 433
 0.8
chr11_119089692_119089843 0.40 Cbx4
 chromobox 4
 3546
 0.18
chr2_172441299_172441621 0.40 Rtf2
 replication termination factor 2
 858
 0.36
chr4_131837128_131837286 0.38 Ptpru
 protein tyrosine phosphatase, receptor type, U
 1024
 0.44
chr5_8971094_8971245 0.37 Gm15610
 predicted gene 15610
 779
 0.53
chr1_39192284_39192607 0.35 Npas2
 neuronal PAS domain protein 2
 1286
 0.45
chr1_183369609_183369773 0.35 Mia3
 melanoma inhibitory activity 3
 138
 0.92
chr5_144885994_144886193 0.34 Smurf1
 SMAD specific E3 ubiquitin protein ligase 1
 383
 0.83
chr17_15192816_15193078 0.34 Gm35455
 predicted gene, 35455
 40788
 0.13
chr16_45377470_45377621 0.34 Cd200
 CD200 antigen
 22767
 0.16
chr5_113735843_113736024 0.34 Ficd
 FIC domain containing
 130
 0.93
chr11_77793030_77793211 0.33 Gm10277
 predicted gene 10277
 5373
 0.16
chr9_61816682_61816855 0.33 Gm19208
 predicted gene, 19208
 34936
 0.17
chr9_57758758_57758995 0.33 Clk3
 CDC-like kinase 3
 3555
 0.17
chr15_101299611_101299792 0.32 Smim41
 small integral membrane protein 41
 6469
 0.1
chr18_75108255_75108425 0.32 Dym
 dymeclin
 6318
 0.2
chr8_41179352_41179538 0.32 Fgl1
 fibrinogen-like protein 1
 35708
 0.13
chr11_118454196_118454347 0.32 Gm11747
 predicted gene 11747
 724
 0.56
chr8_70200077_70200228 0.30 Slc25a42
 solute carrier family 25, member 42
 12104
 0.09
chr10_95408627_95408789 0.30 Socs2
 suppressor of cytokine signaling 2
 4026
 0.16
chr13_54575762_54575922 0.29 Arl10
 ADP-ribosylation factor-like 10
 795
 0.43
chr17_29496086_29496540 0.29 Pim1
 proviral integration site 1
 2906
 0.15
chr2_59600868_59601029 0.29 Tanc1
 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1
 11094
 0.23
chr1_78568521_78568696 0.28 Mogat1
 monoacylglycerol O-acyltransferase 1
 30980
 0.13
chr9_7571293_7571444 0.28 Mmp27
 matrix metallopeptidase 27
 28
 0.97
chr11_115413035_115413484 0.28 Mrpl58
 mitochondrial ribosomal protein L58
 3099
 0.1
chr10_85103610_85103858 0.27 Tmem263
 transmembrane protein 263
 991
 0.4
chr2_6057072_6057245 0.27 Upf2
 UPF2 regulator of nonsense transcripts homolog (yeast)
 6731
 0.22
chr12_86810853_86811037 0.27 Gm10095
 predicted gene 10095
 35522
 0.14
chr12_17376956_17377119 0.27 Mir3066
 microRNA 3066
 21645
 0.13
chr7_109562757_109562937 0.27 Denn2b
 DENN domain containing 2B
 22414
 0.12
chr3_96645795_96645997 0.26 Itga10
 integrin, alpha 10
 312
 0.73
chr14_51914351_51914597 0.26 Ndrg2
 N-myc downstream regulated gene 2
 316
 0.76
chr5_66014048_66014243 0.26 9130230L23Rik
 RIKEN cDNA 9130230L23 gene
 9860
 0.12
chr2_36082178_36082681 0.26 Lhx6
 LIM homeobox protein 6
 11844
 0.12
chr12_80434710_80434908 0.26 Gm30025
 predicted gene, 30025
 400
 0.74
chr4_108216816_108217079 0.26 Zyg11a
 zyg-11 family member A, cell cycle regulator
 975
 0.5
chr5_144891376_144891550 0.25 Smurf1
 SMAD specific E3 ubiquitin protein ligase 1
 4987
 0.17
chr12_21183267_21183628 0.25 AC156032.1
63876
 0.08
chr9_63755131_63755299 0.25 Smad3
 SMAD family member 3
 2779
 0.31
chr16_90856531_90856709 0.25 Gm36363
 predicted gene, 36363
 5657
 0.14
chr16_95729140_95729334 0.25 Ets2
 E26 avian leukemia oncogene 2, 3' domain
 11503
 0.18
chr5_113918817_113918980 0.25 Gm22056
 predicted gene, 22056
 9906
 0.11
chr1_75661119_75661284 0.24 Gm5257
 predicted gene 5257
 24811
 0.15
chr3_93520535_93520702 0.24 S100a11
 S100 calcium binding protein A11
 130
 0.93
chr8_71366812_71367005 0.24 Use1
 unconventional SNARE in the ER 1 homolog (S. cerevisiae)
 34
 0.95
chr5_114707898_114708063 0.23 Tchp
 trichoplein, keratin filament binding
 116
 0.93
chr2_156462736_156462911 0.22 Gm14224
 predicted gene 14224
 7172
 0.12
chr6_91117239_91117541 0.22 Nup210
 nucleoporin 210
 561
 0.7
chr15_85645356_85645520 0.22 Gm49539
 predicted gene, 49539
 645
 0.66
chr8_11727425_11727615 0.22 Arhgef7
 Rho guanine nucleotide exchange factor (GEF7)
 201
 0.88
chr6_145306818_145306981 0.22 Gm44428
 predicted gene, 44428
 2589
 0.17
chr4_144981227_144981590 0.22 Vps13d
 vacuolar protein sorting 13D
 2553
 0.3
chr16_52249852_52250207 0.21 Alcam
 activated leukocyte cell adhesion molecule
 19032
 0.27
chr19_43511661_43512096 0.21 Got1
 glutamic-oxaloacetic transaminase 1, soluble
 3987
 0.15
chr10_53597848_53598018 0.21 Asf1a
 anti-silencing function 1A histone chaperone
 176
 0.62
chr10_84381402_84381782 0.21 Nuak1
 NUAK family, SNF1-like kinase, 1
 10796
 0.2
chr3_52708989_52709165 0.21 Gm22798
 predicted gene, 22798
 13678
 0.2
chr1_36535791_36536054 0.21 Ankrd23
 ankyrin repeat domain 23
 183
 0.87
chr19_8966562_8966728 0.21 Eef1g
 eukaryotic translation elongation factor 1 gamma
 396
 0.66
chr3_27710416_27710593 0.21 Fndc3b
 fibronectin type III domain containing 3B
 65
 0.98
chr10_84409024_84409261 0.20 Nuak1
 NUAK family, SNF1-like kinase, 1
 16754
 0.17
chr2_168742510_168742664 0.20 Atp9a
 ATPase, class II, type 9A
 178
 0.95
chr1_131975685_131975855 0.20 Slc45a3
 solute carrier family 45, member 3
 949
 0.44
chr4_61439599_61439764 0.20 Mup15
 major urinary protein 15
 62
 0.97
chr10_84803969_84804150 0.20 Gm24226
 predicted gene, 24226
 7124
 0.23
chr3_153921648_153921917 0.20 Acadm
 acyl-Coenzyme A dehydrogenase, medium chain
 8360
 0.09
chr4_135434067_135434419 0.20 Rcan3
 regulator of calcineurin 3
 390
 0.72
chr2_104035717_104035881 0.20 Gm24644
 predicted gene, 24644
 4870
 0.12
chr15_99847019_99847476 0.20 Lima1
 LIM domain and actin binding 1
 27104
 0.07
chr9_47637935_47638086 0.20 Cadm1
 cell adhesion molecule 1
 107637
 0.06
chr11_86807573_86807779 0.20 Dhx40
 DEAH (Asp-Glu-Ala-His) box polypeptide 40
 70
 0.98
chr13_64153328_64153492 0.20 Zfp367
 zinc finger protein 367
 208
 0.83
chr4_83221216_83221400 0.19 Ttc39b
 tetratricopeptide repeat domain 39B
 11862
 0.19
chr4_61595719_61595883 0.19 Mup17
 major urinary protein 17
 70
 0.97
chr19_3695153_3695350 0.19 Lrp5
 low density lipoprotein receptor-related protein 5
 8687
 0.1
chr17_12371689_12371855 0.19 Plg
 plasminogen
 6836
 0.16
chr7_44869987_44870160 0.19 Ptov1
 prostate tumor over expressed gene 1
 285
 0.74
chr4_60139744_60139909 0.19 Mup2
 major urinary protein 2
 31
 0.97
chr3_139205794_139206161 0.19 Stpg2
 sperm tail PG rich repeat containing 2
 84
 0.98
chr11_17745312_17745477 0.19 Gm12016
 predicted gene 12016
 106211
 0.07
chr13_94143352_94143530 0.19 Gm15907
 predicted gene 15907
 3324
 0.24
chr1_171294216_171294434 0.18 Ufc1
 ubiquitin-fold modifier conjugating enzyme 1
 615
 0.44
chr11_59428409_59428580 0.18 Snap47
 synaptosomal-associated protein, 47
 18997
 0.1
chr6_55001492_55001666 0.18 Ggct
 gamma-glutamyl cyclotransferase
 8629
 0.17
chr5_117245335_117245486 0.18 Taok3
 TAO kinase 3
 4950
 0.16
chr4_61519388_61519546 0.18 Mup16
 major urinary protein 16
 0
 0.98
chr4_153957077_153957238 0.18 A430005L14Rik
 RIKEN cDNA A430005L14 gene
 80
 0.95
chr15_85036576_85036766 0.18 Fam118a
 family with sequence similarity 118, member A
 418
 0.76
chr12_28910610_28910780 0.18 Gm31508
 predicted gene, 31508
 466
 0.82
chr5_30231710_30232189 0.18 Selenoi
 selenoprotein I
 632
 0.63
chr4_44991523_44991952 0.18 Grhpr
 glyoxylate reductase/hydroxypyruvate reductase
 10237
 0.11
chr7_45139988_45140693 0.18 Flt3l
 FMS-like tyrosine kinase 3 ligand
 3908
 0.05
chr17_74716795_74716985 0.18 Ttc27
 tetratricopeptide repeat domain 27
 842
 0.65
chr12_105297953_105298115 0.18 Tunar
 Tcl1 upstream neural differentiation associated RNA
 35836
 0.14
chr8_127295141_127295294 0.18 Pard3
 par-3 family cell polarity regulator
 4368
 0.35
chr18_34331012_34331178 0.18 Srp19
 signal recognition particle 19
 28
 0.98
chr8_33987157_33987321 0.18 Gm45817
 predicted gene 45817
 39
 0.96
chr18_61489282_61489444 0.17 Gm46637
 predicted gene, 46637
 4597
 0.14
chr5_74943885_74944036 0.17 Gm6116
 predicted gene 6116
 5230
 0.2
chr4_60662258_60662429 0.17 Mup11
 major urinary protein 11
 15
 0.97
chr19_5770906_5771201 0.17 Scyl1
 SCY1-like 1 (S. cerevisiae)
 106
 0.91
chr11_58093075_58093271 0.17 Gm12248
 predicted gene 12248
 39
 0.96
chr1_133278743_133278947 0.17 Plekha6
 pleckstrin homology domain containing, family A member 6
 4591
 0.15
chr16_97418050_97418216 0.17 Bace2
 beta-site APP-cleaving enzyme 2
 3055
 0.21
chr5_66074323_66074506 0.17 Gm43775
 predicted gene 43775
 1519
 0.29
chr17_28930275_28930478 0.17 Gm16191
 predicted gene 16191
 4045
 0.1
chr4_137468313_137468498 0.17 Hspg2
 perlecan (heparan sulfate proteoglycan 2)
 364
 0.81
chr2_127506298_127506464 0.17 AL731831.1
 prominin 2 (Prom2), pseudogene
 12914
 0.13
chr10_128980928_128981107 0.17 Olfr9
 olfactory receptor 9
 8414
 0.09
chr11_21428880_21429060 0.17 Gm12044
 predicted gene 12044
 22384
 0.14
chr1_38864480_38864651 0.16 Chst10
 carbohydrate sulfotransferase 10
 7195
 0.16
chr19_46133855_46134398 0.16 Elovl3
 elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 3
 2229
 0.19
chr12_4039052_4039225 0.16 Efr3b
 EFR3 homolog B
 223
 0.92
chr9_73039846_73040053 0.16 Pigbos1
 Pigb opposite strand 1
 219
 0.5
chr7_27331182_27331346 0.16 Ltbp4
 latent transforming growth factor beta binding protein 4
 2349
 0.17
chr14_77343821_77343990 0.16 Gm49001
 predicted gene, 49001
 281
 0.93
chr4_60070204_60070385 0.16 Mup7
 major urinary protein 7
 117
 0.96
chr12_79684888_79685267 0.16 9430078K24Rik
 RIKEN cDNA 9430078K24 gene
 239656
 0.02
chr7_44999841_45000005 0.16 Irf3
 interferon regulatory factor 3
 244
 0.73
chr2_168127857_168128015 0.16 AL831766.1
 breast carcinoma amplified sequence 4 (BCAS4) pseudogene
 13059
 0.12
chr13_12454823_12454987 0.16 Lgals8
 lectin, galactose binding, soluble 8
 109
 0.96
chr2_148040189_148040578 0.16 9030622O22Rik
 RIKEN cDNA 9030622O22 gene
 180
 0.94
chr14_17683673_17683824 0.16 Thrb
 thyroid hormone receptor beta
 22852
 0.26
chr2_156732212_156732375 0.16 Dlgap4
 DLG associated protein 4
 10801
 0.13
chr2_45253993_45254149 0.16 Gm13475
 predicted gene 13475
 75161
 0.1
chr3_27686853_27687185 0.16 Fndc3b
 fibronectin type III domain containing 3B
 23379
 0.24
chr5_9047464_9048021 0.16 Gm40264
 predicted gene, 40264
 12618
 0.15
chr4_60222408_60222586 0.16 Mup8
 major urinary protein 8
 83
 0.97
chr6_12466411_12466591 0.16 Thsd7a
 thrombospondin, type I, domain containing 7A
 47140
 0.18
chr16_4753759_4754349 0.16 Hmox2
 heme oxygenase 2
 2791
 0.17
chr6_5190649_5191077 0.16 Pon1
 paraoxonase 1
 2900
 0.26
chr15_88894079_88894230 0.16 Gm20621
 predicted gene 20621
 2629
 0.2
chr8_70594556_70594707 0.16 Isyna1
 myo-inositol 1-phosphate synthase A1
 96
 0.93
chr1_152556824_152557014 0.15 Rgl1
 ral guanine nucleotide dissociation stimulator,-like 1
 3875
 0.31
chr10_99615923_99616079 0.15 Gm20110
 predicted gene, 20110
 6830
 0.19
chr16_50430297_50430475 0.15 Bbx
 bobby sox HMG box containing
 474
 0.88
chr7_16924149_16924320 0.15 Calm3
 calmodulin 3
 120
 0.92
chr5_138979896_138980396 0.15 Pdgfa
 platelet derived growth factor, alpha
 14135
 0.17
chr4_60501802_60501955 0.15 Mup1
 major urinary protein 1
 25
 0.94
chr4_32520693_32520870 0.15 Bach2
 BTB and CNC homology, basic leucine zipper transcription factor 2
 19276
 0.19
chr4_116685113_116685395 0.15 Prdx1
 peroxiredoxin 1
 290
 0.83
chr5_129501132_129501293 0.15 Sfswap
 splicing factor SWAP
 9
 0.74
chr6_121329980_121330165 0.15 Gm24855
 predicted gene, 24855
 4396
 0.17
chr5_45476407_45476609 0.15 Lap3
 leucine aminopeptidase 3
 16866
 0.11
chr8_3631331_3631522 0.15 Stxbp2
 syntaxin binding protein 2
 256
 0.79
chr5_116453577_116453751 0.15 Srrm4
 serine/arginine repetitive matrix 4
 249
 0.88
chr2_109978777_109979106 0.15 Lgr4
 leucine-rich repeat-containing G protein-coupled receptor 4
 3399
 0.26
chr8_10899998_10900419 0.15 4833411C07Rik
 RIKEN cDNA 4833411C07 gene
 271
 0.54
chr6_28480072_28480271 0.15 Snd1
 staphylococcal nuclease and tudor domain containing 1
 177
 0.93
chr8_27174337_27174510 0.15 Rab11fip1
 RAB11 family interacting protein 1 (class I)
 204
 0.88
chr9_69289046_69289527 0.15 Rora
 RAR-related orphan receptor alpha
 396
 0.89
chr9_111211971_111212321 0.15 Lrrfip2
 leucine rich repeat (in FLII) interacting protein 2
 2047
 0.3
chr8_77098217_77098409 0.15 Nr3c2
 nuclear receptor subfamily 3, group C, member 2
 29700
 0.19
chr10_59504215_59504400 0.15 Mcu
 mitochondrial calcium uniporter
 46147
 0.13
chr9_61596903_61597054 0.15 Gm34424
 predicted gene, 34424
 63563
 0.12
chr10_13967469_13967637 0.15 Hivep2
 human immunodeficiency virus type I enhancer binding protein 2
 529
 0.78
chr16_92415881_92416059 0.15 Rcan1
 regulator of calcineurin 1
 15893
 0.13
chr3_31122977_31123199 0.14 Skil
 SKI-like
 26255
 0.16
chr11_83834151_83834516 0.14 Gm12576
 predicted gene 12576
 15160
 0.12
chr4_118137948_118138112 0.14 St3gal3
 ST3 beta-galactoside alpha-2,3-sialyltransferase 3
 3116
 0.21
chr1_133452688_133453146 0.14 Sox13
 SRY (sex determining region Y)-box 13
 28540
 0.16
chr7_30360114_30360296 0.14 Lrfn3
 leucine rich repeat and fibronectin type III domain containing 3
 2567
 0.1
chr19_43512283_43512443 0.14 Got1
 glutamic-oxaloacetic transaminase 1, soluble
 3502
 0.15
chr10_18056009_18056160 0.14 Reps1
 RalBP1 associated Eps domain containing protein
 80
 0.97
chr14_122104924_122105095 0.14 A330035P11Rik
 RIKEN cDNA A330035P11 gene
 1944
 0.21
chr16_21646037_21646193 0.14 Vps8
 VPS8 CORVET complex subunit
 18484
 0.2
chr4_53023825_53023983 0.14 Nipsnap3b
 nipsnap homolog 3B
 2928
 0.22
chr11_19992826_19993027 0.14 Spred2
 sprouty-related EVH1 domain containing 2
 38356
 0.18
chr7_73574787_73575110 0.14 1810026B05Rik
 RIKEN cDNA 1810026B05 gene
 16553
 0.1
chr4_118158547_118158710 0.14 Kdm4a
 lysine (K)-specific demethylase 4A
 3029
 0.2
chr7_100042239_100042447 0.14 Chrdl2
 chordin-like 2
 20244
 0.14
chr2_150786904_150787055 0.14 Pygb
 brain glycogen phosphorylase
 244
 0.91
chr5_112893601_112893976 0.14 Myo18b
 myosin XVIIIb
 2574
 0.29
chr6_121841280_121841702 0.14 Mug1
 murinoglobulin 1
 387
 0.88
chr18_12213171_12213322 0.14 Npc1
 NPC intracellular cholesterol transporter 1
 692
 0.62
chr9_103471973_103472146 0.14 Gm16252
 predicted gene 16252
 25
 0.96
chr3_83032424_83032575 0.14 Fga
 fibrinogen alpha chain
 6284
 0.15
chr1_183367200_183367450 0.14 Mia3
 melanoma inhibitory activity 3
 2228
 0.21
chr5_139499620_139499800 0.14 Zfand2a
 zinc finger, AN1-type domain 2A
 15161
 0.13

Histogram of CRE-TSS distances for CREs targeted by :

Histogram of

Rank distribution of CRE target scores:

Histogram of target CRE score.

Distribution of target CREs across different genomic regions:

Weighted Piechart of Weighted Piechart of Weighted Piechart of

Network of associatons between targets according to the STRING database.

First level regulatory network of Xbp1_Creb3l1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 GO:0048208 vesicle targeting, rough ER to cis-Golgi(GO:0048207) COPII vesicle coating(GO:0048208)
0.1 0.3 GO:0052042 induction of programmed cell death(GO:0012502) positive regulation of apoptotic process in other organism(GO:0044533) positive regulation by symbiont of host programmed cell death(GO:0052042) positive regulation by symbiont of host apoptotic process(GO:0052151) positive regulation by organism of programmed cell death in other organism involved in symbiotic interaction(GO:0052330) positive regulation by organism of apoptotic process in other organism involved in symbiotic interaction(GO:0052501) positive regulation of apoptotic process by virus(GO:0060139)
0.1 0.4 GO:1902534 single-organism membrane invagination(GO:1902534)
0.1 0.2 GO:0019254 carnitine metabolic process, CoA-linked(GO:0019254)
0.1 0.2 GO:0090360 platelet-derived growth factor production(GO:0090360) regulation of platelet-derived growth factor production(GO:0090361)
0.0 0.1 GO:0097296 activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:0097296)
0.0 0.1 GO:0036216 response to stem cell factor(GO:0036215) cellular response to stem cell factor stimulus(GO:0036216) Kit signaling pathway(GO:0038109)
0.0 0.2 GO:1990564 protein polyufmylation(GO:1990564) protein K69-linked ufmylation(GO:1990592)
0.0 0.2 GO:0002317 plasma cell differentiation(GO:0002317)
0.0 0.1 GO:0060397 JAK-STAT cascade involved in growth hormone signaling pathway(GO:0060397)
0.0 0.3 GO:0006620 posttranslational protein targeting to membrane(GO:0006620)
0.0 0.3 GO:0043615 astrocyte cell migration(GO:0043615)
0.0 0.2 GO:0060510 Type II pneumocyte differentiation(GO:0060510)
0.0 0.1 GO:0015772 disaccharide transport(GO:0015766) sucrose transport(GO:0015770) oligosaccharide transport(GO:0015772)
0.0 0.1 GO:0070164 negative regulation of adiponectin secretion(GO:0070164)
0.0 0.1 GO:2000189 positive regulation of cholesterol homeostasis(GO:2000189)
0.0 0.1 GO:0050689 negative regulation of defense response to virus by host(GO:0050689)
0.0 0.1 GO:0002071 glandular epithelial cell maturation(GO:0002071)
0.0 0.1 GO:0010735 positive regulation of transcription via serum response element binding(GO:0010735)
0.0 0.1 GO:2001286 regulation of caveolin-mediated endocytosis(GO:2001286)
0.0 0.2 GO:1902018 negative regulation of cilium assembly(GO:1902018)
0.0 0.1 GO:0045472 response to ether(GO:0045472)
0.0 0.2 GO:0051775 response to redox state(GO:0051775)
0.0 0.1 GO:0030070 insulin processing(GO:0030070)
0.0 0.3 GO:0051895 negative regulation of focal adhesion assembly(GO:0051895)
0.0 0.2 GO:1904153 negative regulation of protein exit from endoplasmic reticulum(GO:0070862) negative regulation of retrograde protein transport, ER to cytosol(GO:1904153)
0.0 0.1 GO:0000395 mRNA 5'-splice site recognition(GO:0000395)
0.0 0.0 GO:0046066 purine deoxyribonucleoside diphosphate metabolic process(GO:0009182) dGDP metabolic process(GO:0046066)
0.0 0.1 GO:0003383 apical constriction(GO:0003383)
0.0 0.1 GO:0007525 somatic muscle development(GO:0007525)
0.0 0.0 GO:0043309 regulation of eosinophil degranulation(GO:0043309)
0.0 0.1 GO:0015884 folic acid transport(GO:0015884)
0.0 0.1 GO:0042726 flavin-containing compound metabolic process(GO:0042726)
0.0 0.2 GO:0060297 regulation of sarcomere organization(GO:0060297)
0.0 0.1 GO:0043152 induction of bacterial agglutination(GO:0043152)
0.0 0.1 GO:0032264 IMP salvage(GO:0032264)
0.0 0.0 GO:0002278 eosinophil activation involved in immune response(GO:0002278) eosinophil mediated immunity(GO:0002447) eosinophil degranulation(GO:0043308)
0.0 0.1 GO:0072282 metanephric nephron tubule morphogenesis(GO:0072282)
0.0 0.1 GO:0019482 beta-alanine metabolic process(GO:0019482)
0.0 0.0 GO:1903598 positive regulation of gap junction assembly(GO:1903598)
0.0 0.1 GO:0007089 traversing start control point of mitotic cell cycle(GO:0007089)
0.0 0.1 GO:0061428 negative regulation of transcription from RNA polymerase II promoter in response to hypoxia(GO:0061428)
0.0 0.1 GO:0051791 medium-chain fatty acid metabolic process(GO:0051791)
0.0 0.1 GO:0045053 protein retention in Golgi apparatus(GO:0045053)
0.0 0.0 GO:0019371 cyclooxygenase pathway(GO:0019371)
0.0 0.1 GO:0019401 alditol biosynthetic process(GO:0019401)
0.0 0.1 GO:0001712 ectodermal cell fate commitment(GO:0001712)
0.0 0.1 GO:0042985 negative regulation of amyloid precursor protein biosynthetic process(GO:0042985)
0.0 0.0 GO:0036066 protein O-linked fucosylation(GO:0036066)
0.0 0.0 GO:1901069 guanosine-containing compound catabolic process(GO:1901069)
0.0 0.0 GO:0008050 female courtship behavior(GO:0008050)
0.0 0.1 GO:0006020 inositol metabolic process(GO:0006020)
0.0 0.1 GO:0042256 mature ribosome assembly(GO:0042256)
0.0 0.0 GO:0061623 galactose catabolic process via UDP-galactose(GO:0033499) glycolytic process from galactose(GO:0061623)
0.0 0.1 GO:0008355 olfactory learning(GO:0008355)
0.0 0.1 GO:0042997 negative regulation of Golgi to plasma membrane protein transport(GO:0042997)
0.0 0.1 GO:2000188 regulation of cholesterol homeostasis(GO:2000188)
0.0 0.0 GO:0035434 copper ion transmembrane transport(GO:0035434)
0.0 0.1 GO:0060978 angiogenesis involved in coronary vascular morphogenesis(GO:0060978)
0.0 0.1 GO:0035469 determination of pancreatic left/right asymmetry(GO:0035469)
0.0 0.0 GO:0003032 detection of oxygen(GO:0003032)
0.0 0.0 GO:1902065 response to L-glutamate(GO:1902065)
0.0 0.1 GO:0030259 lipid glycosylation(GO:0030259)
0.0 0.1 GO:0045838 positive regulation of membrane potential(GO:0045838)
0.0 0.0 GO:0045218 zonula adherens maintenance(GO:0045218)
0.0 0.2 GO:0046854 phosphatidylinositol phosphorylation(GO:0046854)
0.0 0.3 GO:0002063 chondrocyte development(GO:0002063)
0.0 0.1 GO:0009186 deoxyribonucleoside diphosphate metabolic process(GO:0009186)
0.0 0.0 GO:2000591 positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway(GO:0035793) regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway(GO:1900238) positive regulation of metanephric mesenchymal cell migration(GO:2000591)
0.0 0.1 GO:0006572 tyrosine catabolic process(GO:0006572)
0.0 0.1 GO:0033523 histone H2B ubiquitination(GO:0033523)
0.0 0.0 GO:0042524 negative regulation of tyrosine phosphorylation of Stat5 protein(GO:0042524)
0.0 0.0 GO:0002019 regulation of renal output by angiotensin(GO:0002019)
0.0 0.0 GO:0019464 glycine catabolic process(GO:0006546) glycine decarboxylation via glycine cleavage system(GO:0019464)
0.0 0.0 GO:0097461 ferric iron import(GO:0033216) ferric iron import into cell(GO:0097461)
0.0 0.1 GO:0017014 protein nitrosylation(GO:0017014)
0.0 0.0 GO:0000715 nucleotide-excision repair, DNA damage recognition(GO:0000715)
0.0 0.1 GO:0060267 positive regulation of respiratory burst(GO:0060267)
0.0 0.0 GO:0009080 alanine catabolic process(GO:0006524) pyruvate family amino acid catabolic process(GO:0009080)
0.0 0.0 GO:0018894 dibenzo-p-dioxin metabolic process(GO:0018894)
0.0 0.2 GO:0005980 glycogen catabolic process(GO:0005980) glucan catabolic process(GO:0009251) cellular polysaccharide catabolic process(GO:0044247)
0.0 0.0 GO:0051790 short-chain fatty acid biosynthetic process(GO:0051790)
0.0 0.1 GO:0071786 endoplasmic reticulum tubular network organization(GO:0071786)
0.0 0.1 GO:0048194 Golgi vesicle budding(GO:0048194)
0.0 0.0 GO:0016554 cytidine to uridine editing(GO:0016554)
0.0 0.0 GO:1900211 mesenchymal cell apoptotic process involved in metanephros development(GO:1900200) regulation of mesenchymal cell apoptotic process involved in metanephros development(GO:1900211) negative regulation of mesenchymal cell apoptotic process involved in metanephros development(GO:1900212)
0.0 0.0 GO:0036444 calcium ion transmembrane import into mitochondrion(GO:0036444)
0.0 0.0 GO:0006651 diacylglycerol biosynthetic process(GO:0006651)
0.0 0.1 GO:0006335 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.0 0.1 GO:0015722 canalicular bile acid transport(GO:0015722)
0.0 0.1 GO:0006526 arginine biosynthetic process(GO:0006526)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0000322 storage vacuole(GO:0000322)
0.0 0.2 GO:0042406 extrinsic component of endoplasmic reticulum membrane(GO:0042406)
0.0 0.1 GO:0044352 pinosome(GO:0044352) macropinosome(GO:0044354)
0.0 0.1 GO:0071141 SMAD protein complex(GO:0071141)
0.0 0.2 GO:0045179 apical cortex(GO:0045179)
0.0 0.1 GO:0033269 internode region of axon(GO:0033269)
0.0 0.1 GO:0005786 signal recognition particle, endoplasmic reticulum targeting(GO:0005786) signal recognition particle(GO:0048500)
0.0 0.1 GO:0005971 ribonucleoside-diphosphate reductase complex(GO:0005971)
0.0 0.1 GO:0070820 tertiary granule(GO:0070820)
0.0 0.2 GO:0016442 RISC complex(GO:0016442) RNAi effector complex(GO:0031332)
0.0 0.1 GO:0016593 Cdc73/Paf1 complex(GO:0016593)
0.0 0.2 GO:0035102 PRC1 complex(GO:0035102)
0.0 0.0 GO:0000110 nucleotide-excision repair factor 1 complex(GO:0000110)
0.0 0.1 GO:0030121 AP-1 adaptor complex(GO:0030121)
0.0 0.1 GO:0071439 clathrin complex(GO:0071439)
0.0 0.1 GO:0000243 commitment complex(GO:0000243)
0.0 0.1 GO:0031462 Cul2-RING ubiquitin ligase complex(GO:0031462)
0.0 0.1 GO:0005577 fibrinogen complex(GO:0005577)
0.0 0.1 GO:0033010 paranodal junction(GO:0033010)
0.0 0.1 GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0008597 calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597)
0.1 0.4 GO:0019957 C-C chemokine binding(GO:0019957)
0.0 0.1 GO:0031800 type 3 metabotropic glutamate receptor binding(GO:0031800)
0.0 0.1 GO:0008184 glycogen phosphorylase activity(GO:0008184)
0.0 0.4 GO:0070411 I-SMAD binding(GO:0070411)
0.0 0.2 GO:0098639 collagen binding involved in cell-matrix adhesion(GO:0098639)
0.0 0.1 GO:0008142 oxysterol binding(GO:0008142)
0.0 0.1 GO:0005072 transforming growth factor beta receptor, cytoplasmic mediator activity(GO:0005072)
0.0 0.1 GO:0008506 sucrose:proton symporter activity(GO:0008506) sucrose transmembrane transporter activity(GO:0008515) disaccharide transmembrane transporter activity(GO:0015154) oligosaccharide transmembrane transporter activity(GO:0015157)
0.0 0.1 GO:0008379 thioredoxin peroxidase activity(GO:0008379)
0.0 0.1 GO:0008312 7S RNA binding(GO:0008312)
0.0 0.1 GO:0005131 growth hormone receptor binding(GO:0005131)
0.0 0.1 GO:0003876 AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.0 0.1 GO:0070644 vitamin D response element binding(GO:0070644)
0.0 0.1 GO:0050815 phosphoserine binding(GO:0050815)
0.0 0.1 GO:0045134 uridine-diphosphatase activity(GO:0045134)
0.0 0.1 GO:0019871 sodium channel inhibitor activity(GO:0019871)
0.0 0.1 GO:0046573 lactonohydrolase activity(GO:0046573) acyl-L-homoserine-lactone lactonohydrolase activity(GO:0102007)
0.0 0.1 GO:0008321 Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.0 0.1 GO:0019166 trans-2-enoyl-CoA reductase (NADPH) activity(GO:0019166)
0.0 0.1 GO:0061731 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.0 0.1 GO:0080130 L-phenylalanine:2-oxoglutarate aminotransferase activity(GO:0080130)
0.0 0.1 GO:0097109 neuroligin family protein binding(GO:0097109)
0.0 0.2 GO:0031432 titin binding(GO:0031432)
0.0 0.1 GO:0034186 apolipoprotein A-I binding(GO:0034186)
0.0 0.0 GO:0046404 ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity(GO:0046404) polydeoxyribonucleotide kinase activity(GO:0051733)
0.0 0.1 GO:1904288 BAT3 complex binding(GO:1904288)
0.0 0.1 GO:0031730 CCR5 chemokine receptor binding(GO:0031730)
0.0 0.0 GO:0004731 purine-nucleoside phosphorylase activity(GO:0004731)
0.0 0.0 GO:0070905 serine binding(GO:0070905)
0.0 0.1 GO:0008430 selenium binding(GO:0008430)
0.0 0.1 GO:0008517 folic acid transporter activity(GO:0008517)
0.0 0.2 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.0 0.1 GO:0003836 beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.0 0.1 GO:0035613 RNA stem-loop binding(GO:0035613)
0.0 0.1 GO:0070191 methionine-R-sulfoxide reductase activity(GO:0070191)
0.0 0.0 GO:0005173 stem cell factor receptor binding(GO:0005173)
0.0 0.0 GO:0004165 dodecenoyl-CoA delta-isomerase activity(GO:0004165)
0.0 0.2 GO:0005186 pheromone activity(GO:0005186)
0.0 0.0 GO:0008823 cupric reductase activity(GO:0008823) ferric-chelate reductase (NADPH) activity(GO:0052851)
0.0 0.2 GO:0019789 SUMO transferase activity(GO:0019789)
0.0 0.0 GO:0072542 protein phosphatase activator activity(GO:0072542)
0.0 0.0 GO:0004144 diacylglycerol O-acyltransferase activity(GO:0004144)
0.0 0.1 GO:0005092 GDP-dissociation inhibitor activity(GO:0005092)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 ST STAT3 PATHWAY STAT3 Pathway
0.0 0.7 PID TGFBR PATHWAY TGF-beta receptor signaling
0.0 0.1 PID IL2 1PATHWAY IL2-mediated signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 REACTOME BINDING AND ENTRY OF HIV VIRION Genes involved in Binding and entry of HIV virion
0.0 0.5 REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.0 0.2 REACTOME IL 6 SIGNALING Genes involved in Interleukin-6 signaling
0.0 0.4 REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.0 0.1 REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.0 0.2 REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.0 0.1 REACTOME PURINE CATABOLISM Genes involved in Purine catabolism
0.0 0.0 REACTOME XENOBIOTICS Genes involved in Xenobiotics
0.0 0.1 REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY Genes involved in TRAF3-dependent IRF activation pathway
0.0 0.2 REACTOME PEROXISOMAL LIPID METABOLISM Genes involved in Peroxisomal lipid metabolism