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ENCSR904DTN: DNase-seq of mouse liver in constant darkness

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for Zbtb16

Z-value: 1.57

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Transcription factors associated with Zbtb16

Gene Symbol	Gene ID	Gene Info
Zbtb16 Ensembl NCBI MGI UniProt	ENSMUSG00000066687.4	Zbtb16

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

Gene	Promoter	Distance	Association probability	Pearson corr. coef.	P-value	Plot
Zbtb16	chr9_48835896_48836064	35	0.982436	0.95	4.2e-03	Click!
Zbtb16	chr9_48784989_48785185	50858	0.146076	0.82	4.6e-02	Click!
Zbtb16	chr9_48835645_48835854	196	0.956505	0.81	4.9e-02	Click!
Zbtb16	chr9_48836417_48836585	279	0.930627	0.77	7.4e-02	Click!
Zbtb16	chr9_48740241_48740405	95622	0.071587	0.74	9.1e-02	Click!

Activity of the Zbtb16 motif across conditions

Conditions sorted by the z-value of the Zbtb16 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr15_61942367_61942518	1.01	Gm37947	predicted gene, 37947	40860	0.16
chr8_93397874_93398136	0.67	Gm45764	predicted gene 45764	900	0.48
chr5_9079887_9080138	0.62	Tmem243	transmembrane protein 243, mitochondrial	20656	0.14
chr6_33039327_33039482	0.60	Gm14540	predicted gene 14540	936	0.53
chr6_42222010_42222363	0.53	Tas2r144	taste receptor, type 2, member 144	6858	0.13
chr11_102240756_102240907	0.53	Hrob	homologous recombination factor with OB-fold	8051	0.09
chr12_79967016_79967483	0.53	Gm8275	predicted gene 8275	12602	0.18
chr15_10997104_10997270	0.52	Slc45a2	solute carrier family 45, member 2	3534	0.2
chr19_23110526_23110678	0.51	2410080I02Rik	RIKEN cDNA 2410080I02 gene	24298	0.14
chr8_10939586_10939983	0.50	Gm44955	predicted gene 44955	8106	0.11
chr11_121616042_121616235	0.50	Tbcd	tubulin-specific chaperone d	14433	0.2
chr11_8607022_8607173	0.47	Tns3	tensin 3	17790	0.28
chr1_106813159_106813457	0.46	Vps4b	vacuolar protein sorting 4B	16580	0.18
chr6_42254630_42254929	0.46	Tmem139	transmembrane protein 139	7180	0.11
chr3_83002544_83002701	0.46	Fgg	fibrinogen gamma chain	5102	0.16
chr1_165609107_165609258	0.45	Mpzl1	myelin protein zero-like 1	364	0.78
chr2_90518427_90518625	0.45	4933423P22Rik	RIKEN cDNA 4933423P22 gene	39276	0.14
chr6_108648533_108648699	0.44	Gm17055	predicted gene 17055	8301	0.16
chr12_109991265_109991416	0.44	Gm34667	predicted gene, 34667	32533	0.1
chr1_138606335_138606734	0.43	Nek7	NIMA (never in mitosis gene a)-related expressed kinase 7	13140	0.17
chr16_30628279_30628596	0.42	Fam43a	family with sequence similarity 43, member A	28714	0.17
chr17_32493234_32493405	0.42	Cyp4f39	cytochrome P450, family 4, subfamily f, polypeptide 39	1161	0.38
chr13_34793448_34793846	0.42	Gm47157	predicted gene, 47157	20897	0.13
chr11_62487235_62487386	0.42	Gm12278	predicted gene 12278	4513	0.13
chr16_71739508_71739663	0.40	Gm22797	predicted gene, 22797	75797	0.11
chr6_128146811_128146971	0.39	Tspan9	tetraspanin 9	3297	0.15
chr7_7187642_7187793	0.39	Zfp418	zinc finger protein 418	16363	0.1
chr19_46899287_46899584	0.38	Nt5c2	5'-nucleotidase, cytosolic II	10140	0.16
chr3_41582728_41583000	0.37	Jade1	jade family PHD finger 1	2008	0.28
chr13_64126684_64127007	0.37	Slc35d2	solute carrier family 35, member D2	2460	0.2
chr4_100479215_100479588	0.37	Ube2u	ubiquitin-conjugating enzyme E2U (putative)	534	0.82
chr5_136379407_136379558	0.36	Mir721	microRNA 721	3679	0.2
chr2_12867074_12867267	0.35	Pter	phosphotriesterase related	56871	0.13
chr2_152663214_152663365	0.35	H13	histocompatibility 13	6172	0.1
chr4_6885340_6885491	0.35	Tox	thymocyte selection-associated high mobility group box	105068	0.07
chr14_114348500_114348688	0.35	Gm19829	predicted gene, 19829	37791	0.23
chr10_24131559_24132178	0.35	Gm40614	predicted gene, 40614	612	0.59
chr19_30128744_30128991	0.34	Gldc	glycine decarboxylase	16364	0.18
chr6_147064387_147064568	0.34	Mrps35	mitochondrial ribosomal protein S35	3226	0.17
chr10_8089089_8089240	0.34	Gm48614	predicted gene, 48614	67872	0.11
chr11_35179112_35179275	0.33	Slit3	slit guidance ligand 3	1410	0.51
chr15_38070580_38070794	0.33	Ubr5	ubiquitin protein ligase E3 component n-recognin 5	7738	0.16
chr9_4380683_4380845	0.33	Msantd4	Myb/SANT-like DNA-binding domain containing 4 with coiled-coils	2771	0.26
chr2_23082221_23082376	0.32	Acbd5	acyl-Coenzyme A binding domain containing 5	1653	0.36
chr16_76398590_76398917	0.31	Gm9843	predicted gene 9843	4899	0.21
chr2_128713314_128713603	0.31	Mertk	MER proto-oncogene tyrosine kinase	14502	0.15
chr11_70522908_70523209	0.31	Psmb6	proteasome (prosome, macropain) subunit, beta type 6	2309	0.1
chr19_41812412_41812564	0.30	Arhgap19	Rho GTPase activating protein 19	10441	0.15
chr5_137679989_137680170	0.30	Agfg2	ArfGAP with FG repeats 2	4601	0.09
chr13_74897511_74897662	0.30	Hnrnpa1l2-ps	heterogeneous nuclear ribonucleoprotein A1-like 2, pseudogene	33281	0.19
chr7_97622705_97622904	0.30	Rsf1os1	remodeling and spacing factor 1, opposite strand 1	22308	0.1
chr10_68444703_68445037	0.30	Cabcoco1	ciliary associated calcium binding coiled-coil 1	80897	0.09
chr12_8643213_8643385	0.29	Pum2	pumilio RNA-binding family member 2	30835	0.16
chr5_87335535_87335718	0.29	Ugt2a3	UDP glucuronosyltransferase 2 family, polypeptide A3	1569	0.26
chr17_29496086_29496540	0.29	Pim1	proviral integration site 1	2906	0.15
chr5_148965317_148966102	0.29	1810059H22Rik	RIKEN cDNA 1810059H22 gene	1435	0.22
chr11_103897919_103898107	0.29	Gm8738	predicted gene 8738	17770	0.18
chr16_23497586_23497756	0.29	Gm49514	predicted gene, 49514	16599	0.13
chr11_101987341_101987516	0.28	Cfap97d1	CFAP97 domain containing 1	372	0.46
chr16_30953629_30953810	0.28	Gm46565	predicted gene, 46565	18090	0.15
chr16_30941233_30941532	0.28	Gm46565	predicted gene, 46565	5753	0.18
chr12_52015542_52015693	0.28	Dtd2	D-tyrosyl-tRNA deacylase 2	9116	0.16
chr11_111605518_111605669	0.28	Gm11676	predicted gene 11676	7713	0.32
chr10_52870918_52871110	0.28	Gm25664	predicted gene, 25664	34624	0.16
chr10_71282973_71283124	0.28	Ube2d1	ubiquitin-conjugating enzyme E2D 1	2170	0.21
chr8_83971032_83971407	0.28	Prkaca	protein kinase, cAMP dependent, catalytic, alpha	1774	0.16
chr16_24394028_24394581	0.28	Lpp	LIM domain containing preferred translocation partner in lipoma	566	0.73
chr5_146270914_146271065	0.28	Cdk8	cyclin-dependent kinase 8	13196	0.14
chr13_34313351_34313741	0.28	Gm47086	predicted gene, 47086	5262	0.21
chr10_10580939_10581232	0.27	Rab32	RAB32, member RAS oncogene family	22820	0.17
chr5_123376677_123377005	0.27	5830487J09Rik	RIKEN cDNA 5830487J09 gene	9842	0.08
chr1_170640374_170640534	0.27	Olfml2b	olfactomedin-like 2B	4078	0.21
chr13_93889949_93890100	0.27	Gm25534	predicted gene, 25534	33287	0.15
chr5_17814871_17815031	0.27	Cd36	CD36 molecule	20745	0.27
chr7_49761513_49761692	0.27	Htatip2	HIV-1 Tat interactive protein 2	2449	0.31
chr11_85738593_85738744	0.27	Bcas3os1	breast carcinoma amplified sequence 3, opposite strand 1	18924	0.14
chr13_100525246_100525436	0.27	Ocln	occludin	27119	0.1
chr13_60173158_60174110	0.26	Gm48488	predicted gene, 48488	3048	0.21
chr2_33444795_33444946	0.26	Gm13536	predicted gene 13536	1932	0.27
chr10_44699857_44700038	0.26	Gm47388	predicted gene, 47388	2767	0.17
chr9_44127033_44127184	0.26	Mcam	melanoma cell adhesion molecule	7361	0.06
chr10_68352578_68352735	0.26	4930545H06Rik	RIKEN cDNA 4930545H06 gene	31514	0.18
chr13_12550644_12550996	0.26	Gm30239	predicted gene, 30239	7420	0.14
chr6_50176151_50176315	0.26	Mpp6	membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6)	4067	0.27
chr19_10051741_10051938	0.26	Fads3	fatty acid desaturase 3	1112	0.39
chr15_29829703_29829875	0.26	Gm23033	predicted gene, 23033	58685	0.14
chr8_119431731_119431882	0.26	Osgin1	oxidative stress induced growth inhibitor 1	2318	0.24
chr6_147064062_147064225	0.25	Mrps35	mitochondrial ribosomal protein S35	2892	0.18
chr2_69228328_69228964	0.25	G6pc2	glucose-6-phosphatase, catalytic, 2	8618	0.15
chr14_20319722_20320198	0.25	Nudt13	nudix (nucleoside diphosphate linked moiety X)-type motif 13	8531	0.12
chr8_45255840_45256130	0.25	F11	coagulation factor XI	6046	0.19
chr5_72365932_72366096	0.25	Corin	corin, serine peptidase	5315	0.18
chr5_129726157_129726319	0.25	Gm15903	predicted gene 15903	808	0.39
chr11_50189181_50189338	0.25	Sqstm1	sequestosome 1	13695	0.1
chr16_76225574_76225868	0.25	Gm26915	predicted gene, 26915	80736	0.08
chr6_137466080_137466336	0.25	Ptpro	protein tyrosine phosphatase, receptor type, O	12180	0.22
chr6_82133100_82133272	0.25	Gm15864	predicted gene 15864	80605	0.08
chr16_31996383_31996610	0.25	Hmgb1-ps6	high mobility group box 1, pseudogene 6	4628	0.09
chr18_46748548_46748699	0.24	Ap3s1	adaptor-related protein complex 3, sigma 1 subunit	6681	0.12
chr12_40508704_40509084	0.24	Dock4	dedicator of cytokinesis 4	62558	0.12
chr14_47205203_47205370	0.24	Gm49136	predicted gene, 49136	5416	0.11
chr8_35349975_35350150	0.24	Ppp1r3b	protein phosphatase 1, regulatory subunit 3B	25677	0.15
chr1_93029762_93029954	0.24	Kif1a	kinesin family member 1A	2653	0.19
chr12_83981935_83982155	0.24	Heatr4	HEAT repeat containing 4	2807	0.14
chr4_143412215_143412366	0.24	Pramef8	PRAME family member 8	136	0.93
chr2_38142003_38142233	0.24	Dennd1a	DENN/MADD domain containing 1A	23963	0.17
chr2_172473776_172473949	0.24	Fam209	family with sequence similarity 209	1342	0.34
chr10_71343007_71343170	0.24	Cisd1	CDGSH iron sulfur domain 1	1866	0.25
chr15_11190225_11190388	0.24	Adamts12	a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 12	125488	0.05
chr2_156145846_156146301	0.24	Romo1	reactive oxygen species modulator 1	1833	0.18
chr18_20210155_20210348	0.23	Dsg1c	desmoglein 1 gamma	37089	0.18
chr7_105818652_105818813	0.23	Gm45912	predicted gene 45912	5074	0.12
chr15_25677510_25677678	0.23	Myo10	myosin X	3084	0.24
chr11_87449212_87449363	0.23	Rnu3b3	U3B small nuclear RNA 3	660	0.48
chr12_24614688_24615076	0.23	Gm6969	predicted pseudogene 6969	24128	0.13
chr10_51722416_51722567	0.23	Rfx6	regulatory factor X, 6	28720	0.12
chr4_146234816_146235138	0.23	Gm13169	predicted gene 13169	4977	0.13
chr4_3875399_3875796	0.23	Mos	Moloney sarcoma oncogene	3492	0.17
chr3_81995220_81995384	0.23	Asic5	acid-sensing (proton-gated) ion channel family member 5	1620	0.35
chr14_59444898_59445049	0.23	Cab39l	calcium binding protein 39-like	3992	0.18
chr9_59019307_59019466	0.23	Neo1	neogenin	17039	0.22
chr9_66330345_66330505	0.22	Herc1	HECT and RLD domain containing E3 ubiquitin protein ligase family member 1	20025	0.18
chr5_124376554_124376745	0.22	Sbno1	strawberry notch 1	8160	0.11
chr12_85809600_85809751	0.22	Erg28	ergosterol biosynthesis 28	12575	0.16
chr17_77596575_77596938	0.22	Gm17538	predicted gene, 17538	77944	0.11
chr8_93146655_93146831	0.22	Gm45910	predicted gene 45910	7373	0.14
chr6_108233581_108233762	0.22	Itpr1	inositol 1,4,5-trisphosphate receptor 1	19287	0.22
chr1_49570933_49571107	0.22	Gm28388	predicted gene 28388	8566	0.29
chr3_82316899_82317195	0.22	Map9	microtubule-associated protein 9	40997	0.19
chr4_155558186_155558588	0.22	Nadk	NAD kinase	3991	0.13
chr19_7523941_7524241	0.22	Atl3	atlastin GTPase 3	29556	0.11
chr4_81508297_81508448	0.22	Gm11765	predicted gene 11765	46640	0.17
chr4_129320984_129321142	0.22	Rbbp4	retinoblastoma binding protein 4, chromatin remodeling factor	13581	0.11
chr5_114589239_114589390	0.22	Fam222a	family with sequence similarity 222, member A	21297	0.14
chr9_43545693_43545878	0.22	Gm36855	predicted gene, 36855	24781	0.17
chr17_79658508_79658667	0.22	Rmdn2	regulator of microtubule dynamics 2	13813	0.21
chr5_108535384_108535540	0.22	Cplx1	complexin 1	14538	0.11
chr1_179608860_179609030	0.22	Cnst	consortin, connexin sorting protein	15555	0.18
chr5_93016355_93016510	0.22	Gm25521	predicted gene, 25521	3293	0.18
chr1_151105258_151105444	0.22	Gm19087	predicted gene, 19087	2564	0.2
chr9_46071982_46072133	0.22	Sik3	SIK family kinase 3	51073	0.1
chr14_30184944_30185295	0.21	Cacna1d	calcium channel, voltage-dependent, L type, alpha 1D subunit	9728	0.2
chr8_93197496_93198044	0.21	Ces1d	carboxylesterase 1D	7	0.97
chr1_165470090_165470241	0.21	Gm37860	predicted gene, 37860	2665	0.14
chr4_107388361_107388798	0.21	Ndc1	NDC1 transmembrane nucleoporin	7117	0.15
chr11_45887104_45887260	0.21	Clint1	clathrin interactor 1	4785	0.19
chr2_166983387_166983579	0.21	Stau1	staufen double-stranded RNA binding protein 1	6712	0.13
chr4_146575212_146575562	0.21	Gm13233	predicted gene 13233	5242	0.13
chr11_106428672_106429050	0.21	Icam2	intercellular adhesion molecule 2	40786	0.1
chr3_29732542_29732732	0.21	Gm37557	predicted gene, 37557	38647	0.19
chr18_31581039_31581190	0.21	B930094E09Rik	RIKEN cDNA B930094E09 gene	28398	0.14
chr16_26163874_26164039	0.21	P3h2	prolyl 3-hydroxylase 2	58172	0.15
chr15_100110403_100110727	0.21	4930478M13Rik	RIKEN cDNA 4930478M13 gene	2404	0.23
chr12_17885844_17886007	0.21	Gm49326	predicted gene, 49326	3728	0.15
chr15_10637560_10637724	0.21	Gm10389	predicted gene 10389	37305	0.13
chr13_119708466_119708617	0.21	Gm48342	predicted gene, 48342	3992	0.14
chr12_40561876_40562268	0.21	Dock4	dedicator of cytokinesis 4	115736	0.06
chr5_117984245_117984410	0.21	Fbxo21	F-box protein 21	5003	0.16
chr4_109116948_109117230	0.21	Osbpl9	oxysterol binding protein-like 9	609	0.77
chr15_78948026_78948177	0.21	Triobp	TRIO and F-actin binding protein	144	0.9
chr11_58927012_58927289	0.21	Btnl10	butyrophilin-like 10	9093	0.06
chr19_58049317_58049501	0.21	Mir5623	microRNA 5623	1758	0.46
chr16_84806178_84806337	0.21	Jam2	junction adhesion molecule 2	3150	0.18
chr13_67830741_67831099	0.21	4930525G20Rik	RIKEN cDNA 4930525G20 gene	65	0.66
chr18_39497961_39498121	0.21	Nr3c1	nuclear receptor subfamily 3, group C, member 1	6740	0.28
chr1_191822042_191822193	0.20	Nek2	NIMA (never in mitosis gene a)-related expressed kinase 2	65	0.58
chr16_28841105_28841256	0.20	Mb21d2	Mab-21 domain containing 2	4813	0.32
chr2_69423254_69423431	0.20	Dhrs9	dehydrogenase/reductase (SDR family) member 9	42897	0.14
chr11_62409500_62409860	0.20	Ncor1	nuclear receptor co-repressor 1	8130	0.16
chr5_24696900_24697051	0.20	Gm26648	predicted gene, 26648	7715	0.13
chr13_98684591_98684906	0.20	Tmem171	transmembrane protein 171	10020	0.14
chr8_40863315_40863480	0.20	Slc7a2	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	819	0.56
chr8_126920805_126921127	0.20	Gm31718	predicted gene, 31718	12751	0.15
chr6_29540672_29541006	0.20	Irf5	interferon regulatory factor 5	307	0.83
chr8_121561590_121561893	0.20	Fbxo31	F-box protein 31	1778	0.22
chr17_13768386_13768604	0.20	Tcte2	t-complex-associated testis expressed 2	6670	0.16
chr8_109972886_109973196	0.20	Gm45795	predicted gene 45795	1311	0.33
chr1_34842105_34842416	0.20	Fam168b	family with sequence similarity 168, member B	704	0.58
chr7_141581336_141581865	0.19	Ap2a2	adaptor-related protein complex 2, alpha 2 subunit	19070	0.1
chr7_73578042_73578281	0.19	1810026B05Rik	RIKEN cDNA 1810026B05 gene	19766	0.1
chr2_166002813_166002989	0.19	Ncoa3	nuclear receptor coactivator 3	10264	0.14
chr2_174499512_174499663	0.19	Gm14385	predicted gene 14385	14011	0.13
chr15_34510659_34511041	0.19	Pop1	processing of precursor 1, ribonuclease P/MRP family, (S. cerevisiae)	943	0.43
chr4_86671562_86671730	0.19	Plin2	perilipin 2	1586	0.38
chr4_41340852_41341003	0.19	Gm26084	predicted gene, 26084	5024	0.12
chr9_101036260_101036546	0.19	Pccb	propionyl Coenzyme A carboxylase, beta polypeptide	1505	0.33
chr5_145855582_145856014	0.19	Cyp3a11	cytochrome P450, family 3, subfamily a, polypeptide 11	20893	0.14
chr2_94042559_94042721	0.19	Hsd17b12	hydroxysteroid (17-beta) dehydrogenase 12	23829	0.14
chr1_51834753_51834904	0.19	Myo1b	myosin IB	14282	0.16
chr3_84011372_84011587	0.19	Tmem131l	transmembrane 131 like	28649	0.2
chr10_122384642_122385270	0.19	Gm36041	predicted gene, 36041	1936	0.39
chr13_35016682_35016867	0.19	Eci2	enoyl-Coenzyme A delta isomerase 2	10320	0.12
chr11_113062597_113062759	0.19	2610035D17Rik	RIKEN cDNA 2610035D17 gene	110399	0.07
chr1_39902031_39902182	0.19	Map4k4	mitogen-activated protein kinase kinase kinase kinase 4	876	0.66
chr13_4013920_4014086	0.19	Gm47853	predicted gene, 47853	9166	0.13
chr10_112953941_112954181	0.19	Gm47519	predicted gene, 47519	6127	0.18
chr7_123124873_123125354	0.19	Tnrc6a	trinucleotide repeat containing 6a	857	0.66
chr8_116237744_116237895	0.18	4930422C21Rik	RIKEN cDNA 4930422C21 gene	50450	0.17
chr8_129135025_129135198	0.18	Ccdc7b	coiled-coil domain containing 7B	1409	0.38
chr5_102548279_102548672	0.18	1700013M08Rik	RIKEN cDNA 1700013M08 gene	65186	0.12

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of Zbtb16

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View png image

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.2	GO:0019626	short-chain fatty acid catabolic process(GO:0019626)
0.1	0.2	GO:0044337	canonical Wnt signaling pathway involved in positive regulation of apoptotic process(GO:0044337)
0.0	0.1	GO:0030242	pexophagy(GO:0030242)
0.0	0.2	GO:0070100	negative regulation of chemokine-mediated signaling pathway(GO:0070100)
0.0	0.1	GO:0035860	glial cell-derived neurotrophic factor receptor signaling pathway(GO:0035860)
0.0	0.1	GO:0030997	regulation of centriole-centriole cohesion(GO:0030997)
0.0	0.2	GO:0021886	hypothalamus gonadotrophin-releasing hormone neuron differentiation(GO:0021886) hypothalamus gonadotrophin-releasing hormone neuron development(GO:0021888)
0.0	0.1	GO:0045041	protein import into mitochondrial intermembrane space(GO:0045041)
0.0	0.1	GO:0033668	negative regulation by symbiont of host apoptotic process(GO:0033668) negative regulation by symbiont of host programmed cell death(GO:0052041) negative regulation by organism of programmed cell death in other organism involved in symbiotic interaction(GO:0052490)
0.0	0.1	GO:0014045	establishment of endothelial blood-brain barrier(GO:0014045)
0.0	0.1	GO:0015766	disaccharide transport(GO:0015766) sucrose transport(GO:0015770) oligosaccharide transport(GO:0015772)
0.0	0.1	GO:0043152	induction of bacterial agglutination(GO:0043152)
0.0	0.1	GO:0034197	acylglycerol transport(GO:0034196) triglyceride transport(GO:0034197)
0.0	0.1	GO:0061511	centriole elongation(GO:0061511)
0.0	0.1	GO:0045896	regulation of transcription during mitosis(GO:0045896) positive regulation of transcription during mitosis(GO:0045897)
0.0	0.1	GO:0072361	regulation of glycolytic process by regulation of transcription from RNA polymerase II promoter(GO:0072361)
0.0	0.1	GO:0050847	progesterone receptor signaling pathway(GO:0050847)
0.0	0.1	GO:1903352	ornithine transport(GO:0015822) L-ornithine transmembrane transport(GO:1903352)
0.0	0.1	GO:0007023	post-chaperonin tubulin folding pathway(GO:0007023)
0.0	0.1	GO:0072378	blood coagulation, fibrin clot formation(GO:0072378)
0.0	0.2	GO:0071257	cellular response to electrical stimulus(GO:0071257)
0.0	0.3	GO:0035278	miRNA mediated inhibition of translation(GO:0035278)
0.0	0.1	GO:0051919	positive regulation of fibrinolysis(GO:0051919)
0.0	0.1	GO:1900126	negative regulation of hyaluronan biosynthetic process(GO:1900126)
0.0	0.1	GO:0006553	lysine metabolic process(GO:0006553)
0.0	0.1	GO:1900169	regulation of glucocorticoid mediated signaling pathway(GO:1900169)
0.0	0.1	GO:0006546	glycine catabolic process(GO:0006546) glycine decarboxylation via glycine cleavage system(GO:0019464)
0.0	0.1	GO:1902036	regulation of hematopoietic stem cell differentiation(GO:1902036)
0.0	0.1	GO:0042998	positive regulation of Golgi to plasma membrane protein transport(GO:0042998)
0.0	0.1	GO:0001543	ovarian follicle rupture(GO:0001543)
0.0	0.1	GO:0071879	positive regulation of adrenergic receptor signaling pathway(GO:0071879)
0.0	0.2	GO:0032534	regulation of microvillus assembly(GO:0032534)
0.0	0.0	GO:2001201	transforming growth factor-beta secretion(GO:0038044) regulation of transforming growth factor-beta secretion(GO:2001201)
0.0	0.1	GO:0048294	negative regulation of isotype switching to IgE isotypes(GO:0048294)
0.0	0.1	GO:0022417	protein maturation by protein folding(GO:0022417)
0.0	0.1	GO:1902775	mitochondrial large ribosomal subunit assembly(GO:1902775)
0.0	0.1	GO:0071787	endoplasmic reticulum tubular network assembly(GO:0071787)
0.0	0.1	GO:0044332	Wnt signaling pathway involved in dorsal/ventral axis specification(GO:0044332)
0.0	0.1	GO:0086046	membrane depolarization during SA node cell action potential(GO:0086046)
0.0	0.2	GO:0032494	response to peptidoglycan(GO:0032494)
0.0	0.1	GO:0009093	cysteine catabolic process(GO:0009093) L-cysteine catabolic process(GO:0019448) L-cysteine metabolic process(GO:0046439)
0.0	0.1	GO:1903232	melanosome assembly(GO:1903232)
0.0	0.1	GO:0060267	positive regulation of respiratory burst(GO:0060267)
0.0	0.0	GO:0042891	antibiotic transport(GO:0042891)
0.0	0.1	GO:0021707	cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
0.0	0.1	GO:0042904	9-cis-retinoic acid biosynthetic process(GO:0042904) 9-cis-retinoic acid metabolic process(GO:0042905)
0.0	0.1	GO:0090315	negative regulation of protein targeting to membrane(GO:0090315)
0.0	0.0	GO:0006391	transcription initiation from mitochondrial promoter(GO:0006391)
0.0	0.0	GO:1900020	regulation of protein kinase C activity(GO:1900019) positive regulation of protein kinase C activity(GO:1900020)
0.0	0.0	GO:0002019	regulation of renal output by angiotensin(GO:0002019)
0.0	0.1	GO:0010528	regulation of transposition(GO:0010528) negative regulation of transposition(GO:0010529)
0.0	0.0	GO:0030167	proteoglycan catabolic process(GO:0030167)
0.0	0.0	GO:0071374	cellular response to parathyroid hormone stimulus(GO:0071374)
0.0	0.0	GO:0032483	regulation of Rab protein signal transduction(GO:0032483)
0.0	0.1	GO:0035405	histone-threonine phosphorylation(GO:0035405)
0.0	0.0	GO:1902268	negative regulation of polyamine transmembrane transport(GO:1902268)
0.0	0.1	GO:1900246	positive regulation of RIG-I signaling pathway(GO:1900246)
0.0	0.1	GO:0060052	neurofilament cytoskeleton organization(GO:0060052)
0.0	0.1	GO:2000507	positive regulation of energy homeostasis(GO:2000507)
0.0	0.1	GO:0015937	coenzyme A biosynthetic process(GO:0015937)
0.0	0.0	GO:0051791	medium-chain fatty acid metabolic process(GO:0051791)
0.0	0.1	GO:0010757	negative regulation of plasminogen activation(GO:0010757)
0.0	0.2	GO:0050860	negative regulation of T cell receptor signaling pathway(GO:0050860)
0.0	0.0	GO:1902075	cellular response to salt(GO:1902075)
0.0	0.1	GO:0006659	phosphatidylserine biosynthetic process(GO:0006659)
0.0	0.1	GO:0070163	adiponectin secretion(GO:0070162) regulation of adiponectin secretion(GO:0070163)
0.0	0.0	GO:0006848	pyruvate transport(GO:0006848)
0.0	0.1	GO:0019919	peptidyl-arginine methylation, to asymmetrical-dimethyl arginine(GO:0019919)
0.0	0.1	GO:0006566	threonine metabolic process(GO:0006566)
0.0	0.0	GO:0032485	regulation of Ral protein signal transduction(GO:0032485)
0.0	0.1	GO:0002904	positive regulation of B cell apoptotic process(GO:0002904)
0.0	0.0	GO:0048388	endosomal lumen acidification(GO:0048388)
0.0	0.1	GO:0097264	self proteolysis(GO:0097264)
0.0	0.0	GO:0060368	regulation of Fc receptor mediated stimulatory signaling pathway(GO:0060368)
0.0	0.0	GO:1904694	negative regulation of vascular smooth muscle contraction(GO:1904694)
0.0	0.1	GO:0061179	negative regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0061179)
0.0	0.0	GO:2000847	negative regulation of steroid hormone secretion(GO:2000832) negative regulation of corticosteroid hormone secretion(GO:2000847) negative regulation of glucocorticoid secretion(GO:2000850)
0.0	0.1	GO:0016078	tRNA catabolic process(GO:0016078)
0.0	0.0	GO:0045404	positive regulation of interleukin-4 biosynthetic process(GO:0045404)
0.0	0.0	GO:1902990	mitotic telomere maintenance via semi-conservative replication(GO:1902990)
0.0	0.0	GO:1904059	regulation of locomotor rhythm(GO:1904059)
0.0	0.1	GO:0001867	complement activation, lectin pathway(GO:0001867)
0.0	0.0	GO:0061091	regulation of phospholipid translocation(GO:0061091) positive regulation of phospholipid translocation(GO:0061092)
0.0	0.1	GO:0019368	fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.0	0.1	GO:0035234	ectopic germ cell programmed cell death(GO:0035234)
0.0	0.1	GO:0003105	negative regulation of glomerular filtration(GO:0003105)
0.0	0.0	GO:0097039	protein linear polyubiquitination(GO:0097039)
0.0	0.1	GO:0043983	histone H4-K12 acetylation(GO:0043983)
0.0	0.1	GO:0015722	canalicular bile acid transport(GO:0015722)
0.0	0.0	GO:0046271	phenylpropanoid metabolic process(GO:0009698) phenylpropanoid catabolic process(GO:0046271)
0.0	0.1	GO:0010746	regulation of plasma membrane long-chain fatty acid transport(GO:0010746)
0.0	0.1	GO:0031339	negative regulation of vesicle fusion(GO:0031339)
0.0	0.1	GO:0060501	positive regulation of epithelial cell proliferation involved in lung morphogenesis(GO:0060501)
0.0	0.0	GO:0000707	meiotic DNA recombinase assembly(GO:0000707)
0.0	0.1	GO:0006534	cysteine metabolic process(GO:0006534)
0.0	0.0	GO:0010248	establishment or maintenance of transmembrane electrochemical gradient(GO:0010248)
0.0	0.0	GO:0038109	response to stem cell factor(GO:0036215) cellular response to stem cell factor stimulus(GO:0036216) Kit signaling pathway(GO:0038109)
0.0	0.0	GO:0018894	dibenzo-p-dioxin metabolic process(GO:0018894)
0.0	0.0	GO:0006741	NADP biosynthetic process(GO:0006741)
0.0	0.0	GO:1903690	negative regulation of wound healing, spreading of epidermal cells(GO:1903690)
0.0	0.1	GO:0008300	isoprenoid catabolic process(GO:0008300)
0.0	0.0	GO:0070537	histone H2A K63-linked deubiquitination(GO:0070537)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:0033503	HULC complex(GO:0033503)
0.0	0.3	GO:0005577	fibrinogen complex(GO:0005577)
0.0	0.1	GO:0005745	m-AAA complex(GO:0005745)
0.0	0.1	GO:0000172	ribonuclease MRP complex(GO:0000172)
0.0	0.1	GO:0000938	GARP complex(GO:0000938)
0.0	0.1	GO:0031088	platelet dense granule membrane(GO:0031088)
0.0	0.1	GO:0030478	actin cap(GO:0030478)
0.0	0.0	GO:0034274	Atg12-Atg5-Atg16 complex(GO:0034274)
0.0	0.1	GO:0046581	intercellular canaliculus(GO:0046581)
0.0	0.1	GO:0090543	Flemming body(GO:0090543)
0.0	0.0	GO:0031523	Myb complex(GO:0031523)
0.0	0.0	GO:0002193	MAML1-RBP-Jkappa- ICN1 complex(GO:0002193)
0.0	0.1	GO:0000127	transcription factor TFIIIC complex(GO:0000127)
0.0	0.0	GO:0031933	telomeric heterochromatin(GO:0031933)
0.0	0.0	GO:0032777	Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.0	0.0	GO:0030981	cortical microtubule cytoskeleton(GO:0030981)
0.0	0.1	GO:0061617	MICOS complex(GO:0061617)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.2	GO:0004771	sterol esterase activity(GO:0004771)
0.0	0.1	GO:0016509	long-chain-3-hydroxyacyl-CoA dehydrogenase activity(GO:0016509)
0.0	0.1	GO:0015157	sucrose:proton symporter activity(GO:0008506) sucrose transmembrane transporter activity(GO:0008515) disaccharide transmembrane transporter activity(GO:0015154) oligosaccharide transmembrane transporter activity(GO:0015157)
0.0	0.2	GO:0070290	N-acylphosphatidylethanolamine-specific phospholipase D activity(GO:0070290)
0.0	0.1	GO:0015252	hydrogen ion channel activity(GO:0015252)
0.0	0.2	GO:0048495	Roundabout binding(GO:0048495)
0.0	0.1	GO:0052658	inositol-1,4,5-trisphosphate 5-phosphatase activity(GO:0052658)
0.0	0.1	GO:0000171	ribonuclease MRP activity(GO:0000171)
0.0	0.1	GO:0018479	benzaldehyde dehydrogenase (NAD+) activity(GO:0018479)
0.0	0.1	GO:0005134	interleukin-2 receptor binding(GO:0005134)
0.0	0.2	GO:0008559	xenobiotic-transporting ATPase activity(GO:0008559)
0.0	0.1	GO:0070053	thrombospondin receptor activity(GO:0070053)
0.0	0.1	GO:0004111	creatine kinase activity(GO:0004111)
0.0	0.1	GO:0015181	arginine transmembrane transporter activity(GO:0015181) L-lysine transmembrane transporter activity(GO:0015189)
0.0	0.1	GO:0005220	inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.0	0.1	GO:0031750	D3 dopamine receptor binding(GO:0031750)
0.0	0.1	GO:0050309	glucose-6-phosphatase activity(GO:0004346) sugar-terminal-phosphatase activity(GO:0050309)
0.0	0.1	GO:0043515	kinetochore binding(GO:0043515)
0.0	0.1	GO:0035651	AP-3 adaptor complex binding(GO:0035651)
0.0	0.1	GO:0019776	Atg8 ligase activity(GO:0019776)
0.0	0.1	GO:0070905	serine binding(GO:0070905)
0.0	0.0	GO:0042895	antibiotic transporter activity(GO:0042895)
0.0	0.1	GO:0015165	pyrimidine nucleotide-sugar transmembrane transporter activity(GO:0015165)
0.0	0.1	GO:0050649	testosterone 6-beta-hydroxylase activity(GO:0050649)
0.0	0.1	GO:0050733	RS domain binding(GO:0050733)
0.0	0.1	GO:0003846	2-acylglycerol O-acyltransferase activity(GO:0003846)
0.0	0.0	GO:0046573	lactonohydrolase activity(GO:0046573) acyl-L-homoserine-lactone lactonohydrolase activity(GO:0102007)
0.0	0.0	GO:0043423	3-phosphoinositide-dependent protein kinase binding(GO:0043423)
0.0	0.1	GO:0043426	MRF binding(GO:0043426)
0.0	0.0	GO:0004366	glycerol-3-phosphate O-acyltransferase activity(GO:0004366)
0.0	0.1	GO:0035033	histone deacetylase regulator activity(GO:0035033)
0.0	0.0	GO:0008073	ornithine decarboxylase inhibitor activity(GO:0008073)
0.0	0.1	GO:0047035	testosterone dehydrogenase (NAD+) activity(GO:0047035)
0.0	0.0	GO:0004430	1-phosphatidylinositol 4-kinase activity(GO:0004430)
0.0	0.0	GO:0004345	glucose-6-phosphate dehydrogenase activity(GO:0004345)
0.0	0.0	GO:0097109	neuroligin family protein binding(GO:0097109)
0.0	0.1	GO:0031849	olfactory receptor binding(GO:0031849)
0.0	0.2	GO:0005452	inorganic anion exchanger activity(GO:0005452)
0.0	0.0	GO:0004833	tryptophan 2,3-dioxygenase activity(GO:0004833)
0.0	0.0	GO:0050833	pyruvate transmembrane transporter activity(GO:0050833)
0.0	0.0	GO:0016635	oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor(GO:0016635)
0.0	0.1	GO:0016846	carbon-sulfur lyase activity(GO:0016846)
0.0	0.1	GO:0009922	fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)
0.0	0.1	GO:0001135	transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
0.0	0.0	GO:0005350	purine nucleobase transmembrane transporter activity(GO:0005345) pyrimidine nucleobase transmembrane transporter activity(GO:0005350) nucleobase transmembrane transporter activity(GO:0015205)
0.0	0.0	GO:0071987	WD40-repeat domain binding(GO:0071987)
0.0	0.0	GO:0047023	androsterone dehydrogenase activity(GO:0047023)
0.0	0.1	GO:0035184	histone threonine kinase activity(GO:0035184)
0.0	0.0	GO:0004165	dodecenoyl-CoA delta-isomerase activity(GO:0004165)
0.0	0.0	GO:0019797	procollagen-proline 3-dioxygenase activity(GO:0019797)
0.0	0.1	GO:0004385	guanylate kinase activity(GO:0004385)
0.0	0.1	GO:0039706	co-receptor binding(GO:0039706)
0.0	0.1	GO:0015349	thyroid hormone transmembrane transporter activity(GO:0015349)
0.0	0.1	GO:0016421	CoA carboxylase activity(GO:0016421)
0.0	0.0	GO:0048101	calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101)
0.0	0.1	GO:0016721	superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721)
0.0	0.0	GO:0086007	voltage-gated calcium channel activity involved in cardiac muscle cell action potential(GO:0086007)
0.0	0.0	GO:0004839	ubiquitin activating enzyme activity(GO:0004839)
0.0	0.1	GO:0017169	CDP-alcohol phosphatidyltransferase activity(GO:0017169)
0.0	0.0	GO:0031752	D5 dopamine receptor binding(GO:0031752)
0.0	0.1	GO:0005247	voltage-gated chloride channel activity(GO:0005247)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.2	PID ECADHERIN STABILIZATION PATHWAY	Stabilization and expansion of the E-cadherin adherens junction

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Total log-likelihood	Term	Description
0.3	REACTOME P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS	Genes involved in p130Cas linkage to MAPK signaling for integrins
0.2	REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS	Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.2	REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS	Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.2	REACTOME VITAMIN B5 PANTOTHENATE METABOLISM	Genes involved in Vitamin B5 (pantothenate) metabolism
0.3	REACTOME REGULATORY RNA PATHWAYS	Genes involved in Regulatory RNA pathways
0.1	REACTOME ROLE OF DCC IN REGULATING APOPTOSIS	Genes involved in Role of DCC in regulating apoptosis
0.3	REACTOME NETRIN1 SIGNALING	Genes involved in Netrin-1 signaling
0.1	REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION	Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.2	REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS	Genes involved in Trafficking of GluR2-containing AMPA receptors
0.2	REACTOME APC CDC20 MEDIATED DEGRADATION OF NEK2A	Genes involved in APC-Cdc20 mediated degradation of Nek2A
0.3	REACTOME SYNTHESIS OF PA	Genes involved in Synthesis of PA