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ENCSR904DTN: DNase-seq of mouse liver in constant darkness

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for Zfp148

Z-value: 1.00

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Transcription factors associated with Zfp148

Gene Symbol	Gene ID	Gene Info
Zfp148 Ensembl NCBI MGI UniProt	ENSMUSG00000022811.10	Zfp148

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

Gene	Promoter	Distance	Association probability	Pearson corr. coef.	P-value	Plot
Zfp148	chr16_33394234_33394423	6117	0.227114	-0.60	2.1e-01	Click!
Zfp148	chr16_33404197_33404348	3827	0.264431	0.57	2.4e-01	Click!
Zfp148	chr16_33400060_33400223	304	0.915765	-0.54	2.6e-01	Click!
Zfp148	chr16_33408360_33408511	7990	0.227147	-0.45	3.7e-01	Click!
Zfp148	chr16_33401041_33401192	671	0.741024	-0.43	4.0e-01	Click!

Activity of the Zfp148 motif across conditions

Conditions sorted by the z-value of the Zfp148 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr6_127341729_127341929	0.85	Gm42458	predicted gene 42458	15972	0.12
chr9_74892937_74893252	0.84	Onecut1	one cut domain, family member 1	26610	0.14
chr7_139388680_139389161	0.72	Inpp5a	inositol polyphosphate-5-phosphatase A	189	0.96
chr1_178600841_178601326	0.56	Gm24405	predicted gene, 24405	35822	0.18
chr9_122634913_122635137	0.50	Gm47134	predicted gene, 47134	12805	0.13
chr7_15939282_15939433	0.48	Snord23	small nucleolar RNA, C/D box 23	487	0.65
chr18_12947344_12947514	0.45	Osbpl1a	oxysterol binding protein-like 1A	5588	0.19
chr18_76542799_76542950	0.44	Gm31933	predicted gene, 31933	89996	0.09
chr10_86689713_86689885	0.43	Gm15344	predicted gene 15344	3296	0.09
chr17_36867279_36867493	0.42	Trim15	tripartite motif-containing 15	176	0.87
chr5_125524109_125525122	0.38	Tmem132b	transmembrane protein 132B	7159	0.16
chr9_22070765_22071174	0.38	Gm16845	predicted gene, 16845	33	0.67
chr15_27477536_27477721	0.38	Tiaf2	TGF-beta1-induced anti-apoptotic factor 2	1378	0.37
chr14_118783672_118783823	0.37	Cldn10	claudin 10	4161	0.19
chr6_35259636_35259787	0.37	1810058I24Rik	RIKEN cDNA 1810058I24 gene	6979	0.16
chr19_22930600_22930751	0.36	Gm50136	predicted gene, 50136	130779	0.05
chr10_80577672_80578424	0.34	Klf16	Kruppel-like factor 16	727	0.41
chr5_144255609_144256174	0.33	2900089D17Rik	RIKEN cDNA 2900089D17 gene	295	0.71
chr5_134887912_134888078	0.32	Tmem270	transmembrane protein 270	18738	0.09
chr11_98775529_98775744	0.32	Nr1d1	nuclear receptor subfamily 1, group D, member 1	303	0.81
chr1_20619402_20619555	0.31	Pkhd1	polycystic kidney and hepatic disease 1	1414	0.43
chr10_127351803_127352162	0.31	Inhbe	inhibin beta-E	2429	0.13
chr7_25686720_25687008	0.29	Tgfb1	transforming growth factor, beta 1	138	0.91
chr10_128746357_128746529	0.29	Pym1	PYM homolog 1, exon junction complex associated factor	1446	0.19
chr11_3332327_3332681	0.29	Pik3ip1	phosphoinositide-3-kinase interacting protein 1	53	0.94
chr4_117997004_117997205	0.29	9530034E10Rik	RIKEN cDNA 9530034E10 gene	22068	0.14
chr5_52613790_52613948	0.29	8030423F21Rik	RIKEN cDNA 8030423F21 gene	5143	0.18
chr1_21264707_21265188	0.29	Gm28836	predicted gene 28836	6646	0.11
chr5_125528257_125528432	0.29	Tmem132b	transmembrane protein 132B	3430	0.21
chr3_142745096_142745348	0.29	Gm15540	predicted gene 15540	541	0.67
chr19_37434647_37435026	0.28	Hhex	hematopoietically expressed homeobox	26	0.69
chr2_25145394_25145761	0.28	Gm13387	predicted gene 13387	181	0.87
chr19_10101442_10101987	0.28	Fads2	fatty acid desaturase 2	32	0.97
chr7_144942500_144942684	0.28	Ccnd1	cyclin D1	2667	0.2
chr9_105465998_105466149	0.28	Atp2c1	ATPase, Ca++-sequestering	4317	0.19
chr1_168281652_168281964	0.28	Gm37524	predicted gene, 37524	55863	0.14
chr4_139631622_139632150	0.28	Aldh4a1	aldehyde dehydrogenase 4 family, member A1	8777	0.14
chr14_117326010_117326161	0.27	Gpc6	glypican 6	400149	0.01
chr6_82760855_82761006	0.27	Gm17034	predicted gene 17034	3352	0.19
chr1_172274690_172274870	0.27	Atp1a2	ATPase, Na+/K+ transporting, alpha 2 polypeptide	1698	0.22
chr6_15777156_15777307	0.27	Gm43924	predicted gene, 43924	34092	0.18
chr5_147321463_147321654	0.27	Urad	ureidoimidazoline (2-oxo-4-hydroxy-4-carboxy-5) decarboxylase	882	0.42
chr11_98839480_98839639	0.26	Rapgefl1	Rap guanine nucleotide exchange factor (GEF)-like 1	2774	0.15
chr19_14586215_14586387	0.26	Tle4	transducin-like enhancer of split 4	9238	0.28
chr5_135719979_135720130	0.26	Por	P450 (cytochrome) oxidoreductase	4049	0.12
chr3_79994107_79994258	0.25	A330069K06Rik	RIKEN cDNA A330069K06 gene	60710	0.11
chr5_122109359_122109528	0.25	Ccdc63	coiled-coil domain containing 63	1670	0.28
chr6_91736603_91736766	0.25	Slc6a6	solute carrier family 6 (neurotransmitter transporter, taurine), member 6	2965	0.19
chr14_47534004_47534155	0.25	Gm49004	predicted gene, 49004	7901	0.12
chr4_138979154_138979535	0.25	Tmco4	transmembrane and coiled-coil domains 4	6435	0.16
chr9_107307749_107307922	0.25	Gm17041	predicted gene 17041	5997	0.1
chr4_139629117_139629268	0.25	Aldh4a1	aldehyde dehydrogenase 4 family, member A1	6083	0.15
chr14_26454997_26455164	0.25	Slmap	sarcolemma associated protein	5092	0.18
chr16_17924359_17924530	0.24	AA914427	EST AA914427	2401	0.13
chr4_135989135_135989286	0.24	Pithd1	PITH (C-terminal proteasome-interacting domain of thioredoxin-like) domain containing 1	1946	0.16
chr16_34925073_34925241	0.24	Mylk	myosin, light polypeptide kinase	5185	0.21
chr5_57743122_57743273	0.24	Gm42635	predicted gene 42635	18804	0.12
chr5_33053298_33053472	0.24	Gm43849	predicted gene 43849	3400	0.18
chr12_16753229_16753413	0.24	Greb1	gene regulated by estrogen in breast cancer protein	3874	0.2
chr1_170997840_170997991	0.24	Gm10522	predicted gene 10522	15971	0.08
chr2_30547946_30548102	0.23	Gm14487	predicted gene 14487	13295	0.16
chr13_107469451_107469885	0.23	AI197445	expressed sequence AI197445	154	0.97
chr10_127577568_127577719	0.23	Lrp1	low density lipoprotein receptor-related protein 1	4242	0.13
chr8_117548542_117548713	0.23	Gm27361	predicted gene, 27361	1601	0.41
chr18_38406873_38407073	0.23	Ndfip1	Nedd4 family interacting protein 1	3423	0.18
chr4_155894332_155894496	0.23	Acap3	ArfGAP with coiled-coil, ankyrin repeat and PH domains 3	2102	0.12
chr2_27595201_27595352	0.23	Gm13421	predicted gene 13421	54847	0.1
chr12_104882664_104882819	0.22	4930408O17Rik	RIKEN cDNA 4930408O17 gene	17411	0.16
chr15_98734151_98734335	0.22	Fkbp11	FK506 binding protein 11	6045	0.1
chr9_119475158_119475309	0.22	Exog	endo/exonuclease (5'-3'), endonuclease G-like	30246	0.12
chr14_75055064_75055264	0.22	Rubcnl	RUN and cysteine rich domain containing beclin 1 interacting protein like	18542	0.18
chr15_25622272_25622843	0.22	Myo10	myosin X	8	0.98
chr8_81341615_81341766	0.22	Inpp4b	inositol polyphosphate-4-phosphatase, type II	866	0.66
chr10_86793800_86793963	0.22	Nt5dc3	5'-nucleotidase domain containing 3	14876	0.11
chr6_88299541_88299692	0.22	Gm44265	predicted gene, 44265	53990	0.09
chr15_100100443_100100600	0.21	4930478M13Rik	RIKEN cDNA 4930478M13 gene	7640	0.15
chr6_91525048_91525199	0.21	Gm45216	predicted gene 45216	2714	0.17
chr5_35033214_35033391	0.21	Gm43791	predicted gene 43791	143	0.94
chr11_65002970_65003224	0.20	Elac2	elaC ribonuclease Z 2	2761	0.28
chr5_112242342_112242634	0.20	Cryba4	crystallin, beta A4	8674	0.11
chr9_107315743_107315923	0.20	Hemk1	HemK methyltransferase family member 1	13619	0.09
chr4_141873016_141873167	0.20	Efhd2	EF hand domain containing 2	1829	0.2
chr19_10634110_10634499	0.20	Vwce	von Willebrand factor C and EGF domains	22	0.95
chr18_75380339_75380510	0.20	Smad7	SMAD family member 7	5510	0.23
chr11_90389588_90389755	0.20	Hlf	hepatic leukemia factor	19	0.99
chr12_76927037_76927196	0.20	Max	Max protein	12878	0.15
chr1_151500754_151501127	0.20	Rnf2	ring finger protein 2	15	0.95
chr19_4462072_4462253	0.20	Syt12	synaptotagmin XII	10011	0.12
chr8_105090572_105090895	0.20	Ces3b	carboxylesterase 3B	2114	0.18
chr18_4691956_4692115	0.19	Jcad	junctional cadherin 5 associated	42967	0.15
chr16_35635109_35635270	0.19	Sema5b	sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5B	22906	0.17
chr7_4504776_4504978	0.19	Tnnt1	troponin T1, skeletal, slow	3148	0.1
chr9_62491243_62491394	0.19	Coro2b	coronin, actin binding protein, 2B	19180	0.2
chr6_128090958_128091168	0.19	Gm26338	predicted gene, 26338	3963	0.19
chr5_111378490_111378641	0.19	Pitpnb	phosphatidylinositol transfer protein, beta	1604	0.34
chr14_74924136_74924288	0.19	Gm10847	predicted gene 10847	2233	0.32
chr16_20716096_20716505	0.19	Clcn2	chloride channel, voltage-sensitive 2	136	0.88
chr8_95884773_95884931	0.19	Got2	glutamatic-oxaloacetic transaminase 2, mitochondrial	3540	0.14
chr6_88292396_88292777	0.19	Gm44265	predicted gene, 44265	61020	0.08
chr17_47304315_47304500	0.19	Trerf1	transcriptional regulating factor 1	10338	0.16
chr10_23894548_23894745	0.19	Vnn1	vanin 1	42	0.96
chr11_98768600_98768751	0.18	Nr1d1	nuclear receptor subfamily 1, group D, member 1	1751	0.2
chr10_69910495_69910908	0.18	Ank3	ankyrin 3, epithelial	4164	0.35
chr11_98785850_98786019	0.18	Msl1	male specific lethal 1	9582	0.09
chr4_129810784_129811411	0.18	Ptp4a2	protein tyrosine phosphatase 4a2	122	0.95
chr3_65658910_65659081	0.18	Mir8120	microRNA 8120	293	0.87
chr18_12663657_12663965	0.18	Gm41668	predicted gene, 41668	15392	0.14
chr7_66689696_66689866	0.18	Lins1	lines homolog 1	108	0.61
chr12_112593582_112593778	0.18	Inf2	inverted formin, FH2 and WH2 domain containing	4414	0.16
chr9_108820189_108820340	0.18	Gm35025	predicted gene, 35025	4555	0.09
chr9_43744780_43745133	0.18	Nectin1	nectin cell adhesion molecule 1	312	0.63
chrX_140541717_140541904	0.18	Tsc22d3	TSC22 domain family, member 3	858	0.63
chr13_48260781_48261195	0.18	Id4	inhibitor of DNA binding 4	240	0.85
chr2_32448342_32448493	0.17	Naif1	nuclear apoptosis inducing factor 1	2040	0.18
chr1_45904282_45904665	0.17	Gm18303	predicted gene, 18303	1150	0.39
chr7_141193568_141193999	0.17	Hras	Harvey rat sarcoma virus oncogene	99	0.77
chr19_26746874_26747161	0.17	Smarca2	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2	583	0.8
chr5_34346535_34346723	0.17	Rnf4	ring finger protein 4	4487	0.15
chr9_122635651_122636097	0.17	Gm47134	predicted gene, 47134	11956	0.13
chr11_83596101_83596252	0.17	Ccl6	chemokine (C-C motif) ligand 6	3089	0.14
chr4_136090324_136090475	0.17	Gm13009	predicted gene 13009	15427	0.12
chr1_55052302_55052488	0.17	Coq10b	coenzyme Q10B	375	0.63
chr5_74738458_74738660	0.17	Gm15985	predicted gene 15985	4108	0.2
chr11_55461149_55461526	0.17	Atox1	antioxidant 1 copper chaperone	98	0.94
chr9_107660530_107661377	0.17	Slc38a3	solute carrier family 38, member 3	1425	0.2
chr2_4508012_4508163	0.17	Frmd4a	FERM domain containing 4A	34893	0.15
chr14_59219365_59219526	0.17	Rcbtb1	regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1	1840	0.33
chr9_65679332_65679533	0.17	Oaz2	ornithine decarboxylase antizyme 2	2841	0.22
chr7_45705992_45706174	0.17	Dbp	D site albumin promoter binding protein	799	0.31
chr5_146247315_146247530	0.17	Gm15739	predicted gene 15739	1129	0.38
chr2_152925622_152925788	0.17	Foxs1	forkhead box S1	7503	0.12
chr3_90615494_90615652	0.17	S100a6	S100 calcium binding protein A6 (calcyclin)	1813	0.16
chr7_132713503_132713681	0.17	Gm15582	predicted gene 15582	53708	0.1
chr11_69996851_69997024	0.17	Phf23	PHD finger protein 23	4	0.92
chr6_37870282_37871066	0.16	Trim24	tripartite motif-containing 24	137	0.96
chr11_98770698_98771034	0.16	Nr1d1	nuclear receptor subfamily 1, group D, member 1	440	0.69
chr5_73993652_73993812	0.16	Usp46os1	ubiquitin specific peptidase 46, opposite strand 1	20483	0.13
chr7_26304515_26304666	0.16	Cyp2a4	cytochrome P450, family 2, subfamily a, polypeptide 4	2579	0.18
chr14_45452270_45452458	0.16	Gm34250	predicted gene, 34250	5291	0.14
chr8_25806161_25806351	0.16	Star	steroidogenic acute regulatory protein	299	0.83
chr13_31558063_31558442	0.16	A530084C06Rik	RIKEN cDNA A530084C06 gene	1081	0.38
chr11_106263631_106263795	0.16	Smarcd2	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2	1223	0.25
chr5_135161333_135161493	0.16	Bcl7b	B cell CLL/lymphoma 7B	6870	0.11
chr15_76195723_76195905	0.16	Plec	plectin	104	0.92
chr16_38376538_38376695	0.16	Popdc2	popeye domain containing 2	4618	0.14
chr15_59062348_59062499	0.16	Mtss1	MTSS I-BAR domain containing 1	6959	0.24
chr10_89460241_89460393	0.16	Gas2l3	growth arrest-specific 2 like 3	16350	0.22
chr11_100398084_100398235	0.16	Jup	junction plakoglobin	396	0.67
chr11_16813698_16813849	0.16	Egfros	epidermal growth factor receptor, opposite strand	16929	0.21
chr14_62761438_62761880	0.16	Ints6	integrator complex subunit 6	490	0.76
chr2_30185581_30185818	0.15	Spout1	SPOUT domain containing methyltransferase 1	7240	0.1
chr17_78417642_78418010	0.15	Fez2	fasciculation and elongation protein zeta 2 (zygin II)	135	0.95
chr13_9145204_9145368	0.15	Gm28155	predicted gene 28155	4405	0.19
chr11_16862611_16863177	0.15	Egfr	epidermal growth factor receptor	15256	0.19
chr10_95508892_95509043	0.15	Ube2n	ubiquitin-conjugating enzyme E2N	6178	0.13
chr12_86836691_86837004	0.15	Gm10095	predicted gene 10095	9620	0.19
chr2_181918621_181918792	0.15	Gm5466	predicted gene 5466	21883	0.17
chr7_19928412_19928563	0.15	Pvr	poliovirus receptor	7327	0.08
chr1_133363345_133363819	0.15	Etnk2	ethanolamine kinase 2	6	0.97
chr8_95888030_95888197	0.14	Got2	glutamatic-oxaloacetic transaminase 2, mitochondrial	279	0.85
chr9_75040383_75040575	0.14	Arpp19	cAMP-regulated phosphoprotein 19	2562	0.24
chr15_58995280_58995901	0.14	4930544F09Rik	RIKEN cDNA 4930544F09 gene	11454	0.17
chr7_89558667_89558818	0.14	Gm45064	predicted gene 45064	6376	0.17
chr14_25207344_25207704	0.14	4930572O13Rik	RIKEN cDNA 4930572O13 gene	64283	0.1
chr7_133315419_133315795	0.14	Gm45672	predicted gene 45672	17594	0.25
chr4_3373410_3373589	0.14	Gm11784	predicted gene 11784	13347	0.2
chr13_47043121_47043523	0.14	Tpmt	thiopurine methyltransferase	21	0.68
chr7_140851973_140852179	0.14	Bet1l	Bet1 golgi vesicular membrane trafficking protein like	4170	0.07
chr17_28495920_28496094	0.14	Fkbp5	FK506 binding protein 5	9858	0.08
chr15_27496291_27496442	0.14	B230362B09Rik	RIKEN cDNA B230362B09 gene	7546	0.17
chr3_137940872_137941024	0.14	Dapp1	dual adaptor for phosphotyrosine and 3-phosphoinositides 1	13765	0.1
chr3_89378414_89378785	0.14	Zbtb7b	zinc finger and BTB domain containing 7B	8590	0.06
chr7_118250628_118250799	0.14	4930583K01Rik	RIKEN cDNA 4930583K01 gene	6848	0.14
chr14_7974818_7975082	0.14	Dnase1l3	deoxyribonuclease 1-like 3	2272	0.27
chr8_90869900_90870054	0.14	Gm45640	predicted gene 45640	6604	0.14
chr1_177495025_177495183	0.14	Gm37306	predicted gene, 37306	27726	0.14
chr19_6415578_6415765	0.14	Gm14965	predicted gene 14965	2935	0.12
chr18_84087281_84087954	0.13	Tshz1	teashirt zinc finger family member 1	89	0.85
chr2_59670423_59670592	0.13	Tanc1	tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1	23696	0.24
chr8_121980914_121981086	0.13	Banp	BTG3 associated nuclear protein	2678	0.16
chr4_150909812_150910129	0.13	Park7	Parkinson disease (autosomal recessive, early onset) 7	44	0.97
chr1_36095531_36095713	0.13	Hs6st1	heparan sulfate 6-O-sulfotransferase 1	6068	0.15
chr5_111509539_111510088	0.13	C130026L21Rik	RIKEN cDNA C130026L21 gene	71609	0.09
chr1_82554461_82554615	0.13	Col4a4	collagen, type IV, alpha 4	32254	0.15
chr15_81896525_81896724	0.13	Aco2	aconitase 2, mitochondrial	1318	0.26
chr2_51147047_51147231	0.13	Rnd3	Rho family GTPase 3	1955	0.41
chr2_103485095_103485448	0.13	Cat	catalase	111	0.97
chr6_125161019_125161494	0.13	Gapdh	glyceraldehyde-3-phosphate dehydrogenase	1271	0.2
chr7_127026907_127027653	0.13	Maz	MYC-associated zinc finger protein (purine-binding transcription factor)	243	0.69
chr15_78845338_78845568	0.13	Cdc42ep1	CDC42 effector protein (Rho GTPase binding) 1	2829	0.13
chr5_151059334_151059485	0.13	Stard13	StAR-related lipid transfer (START) domain containing 13	29853	0.18
chr11_6111840_6112016	0.13	Nudcd3	NudC domain containing 3	7481	0.17
chr5_66679334_66679485	0.13	Uchl1	ubiquitin carboxy-terminal hydrolase L1	2517	0.2
chr15_81815014_81815199	0.13	Tef	thyrotroph embryonic factor	2947	0.14
chr8_105131845_105132023	0.13	Ces4a	carboxylesterase 4A	134	0.92
chr12_76369660_76370048	0.13	Zbtb25	zinc finger and BTB domain containing 25	252	0.62
chr19_4493105_4493260	0.13	2010003K11Rik	RIKEN cDNA 2010003K11 gene	5401	0.13
chr16_22163049_22163219	0.13	Igf2bp2	insulin-like growth factor 2 mRNA binding protein 2	115	0.96
chr8_104926939_104927098	0.13	Ces2e	carboxylesterase 2E	754	0.48
chr5_38486025_38486222	0.13	Slc2a9	solute carrier family 2 (facilitated glucose transporter), member 9	2738	0.25

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of Zfp148

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:1901252	regulation of intracellular transport of viral material(GO:1901252)
0.1	0.3	GO:0048290	isotype switching to IgA isotypes(GO:0048290) regulation of isotype switching to IgA isotypes(GO:0048296)
0.1	0.2	GO:1901097	negative regulation of autophagosome maturation(GO:1901097)
0.1	0.1	GO:0043553	negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553)
0.1	0.4	GO:0034144	negative regulation of toll-like receptor 4 signaling pathway(GO:0034144)
0.1	0.2	GO:0061010	gall bladder development(GO:0061010)
0.1	0.8	GO:0046855	inositol phosphate dephosphorylation(GO:0046855)
0.1	0.2	GO:0006768	biotin metabolic process(GO:0006768)
0.1	0.2	GO:0060741	prostate gland stromal morphogenesis(GO:0060741)
0.1	0.2	GO:0006106	fumarate metabolic process(GO:0006106)
0.1	0.2	GO:0006868	glutamine transport(GO:0006868)
0.0	0.1	GO:1900825	regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900825)
0.0	0.1	GO:0035887	aortic smooth muscle cell differentiation(GO:0035887)
0.0	0.2	GO:0002159	desmosome assembly(GO:0002159)
0.0	0.2	GO:0031581	hemidesmosome assembly(GO:0031581)
0.0	0.2	GO:0090435	protein localization to nuclear envelope(GO:0090435)
0.0	0.3	GO:0070141	response to UV-A(GO:0070141)
0.0	0.2	GO:0009446	putrescine biosynthetic process(GO:0009446)
0.0	0.1	GO:2001013	epithelial cell proliferation involved in renal tubule morphogenesis(GO:2001013)
0.0	0.1	GO:0006990	positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response(GO:0006990)
0.0	0.1	GO:0061144	alveolar secondary septum development(GO:0061144)
0.0	0.2	GO:0060689	cell differentiation involved in salivary gland development(GO:0060689)
0.0	0.1	GO:0072429	response to intra-S DNA damage checkpoint signaling(GO:0072429)
0.0	0.1	GO:0046098	guanine metabolic process(GO:0046098)
0.0	0.2	GO:0070562	regulation of vitamin D receptor signaling pathway(GO:0070562)
0.0	0.1	GO:1900368	regulation of RNA interference(GO:1900368)
0.0	0.1	GO:0032058	positive regulation of translational initiation in response to stress(GO:0032058)
0.0	0.2	GO:0006646	phosphatidylethanolamine biosynthetic process(GO:0006646)
0.0	0.1	GO:1903121	regulation of TRAIL-activated apoptotic signaling pathway(GO:1903121)
0.0	0.1	GO:0000189	MAPK import into nucleus(GO:0000189)
0.0	0.1	GO:2001025	positive regulation of response to drug(GO:2001025)
0.0	0.1	GO:0060283	negative regulation of oocyte development(GO:0060283)
0.0	0.1	GO:0003419	growth plate cartilage chondrocyte proliferation(GO:0003419)
0.0	0.1	GO:0006059	hexitol metabolic process(GO:0006059)
0.0	0.1	GO:0006703	estrogen biosynthetic process(GO:0006703)
0.0	0.1	GO:0010606	positive regulation of cytoplasmic mRNA processing body assembly(GO:0010606)
0.0	0.1	GO:0070488	neutrophil aggregation(GO:0070488)
0.0	0.1	GO:1902222	L-phenylalanine catabolic process(GO:0006559) erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process(GO:1902222)
0.0	0.2	GO:2000650	negative regulation of sodium ion transmembrane transporter activity(GO:2000650)
0.0	0.1	GO:0042271	susceptibility to natural killer cell mediated cytotoxicity(GO:0042271)
0.0	0.1	GO:1900029	positive regulation of ruffle assembly(GO:1900029)
0.0	0.1	GO:0060023	soft palate development(GO:0060023)
0.0	0.1	GO:0000255	allantoin metabolic process(GO:0000255)
0.0	0.1	GO:0006369	termination of RNA polymerase II transcription(GO:0006369)
0.0	0.1	GO:0070236	negative regulation of activation-induced cell death of T cells(GO:0070236)
0.0	0.1	GO:0010032	meiotic chromosome condensation(GO:0010032)
0.0	0.1	GO:0006537	glutamate biosynthetic process(GO:0006537)
0.0	0.1	GO:0050916	sensory perception of sweet taste(GO:0050916)
0.0	0.1	GO:1902459	positive regulation of stem cell population maintenance(GO:1902459)
0.0	0.0	GO:1903377	negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903377)
0.0	0.1	GO:0048294	negative regulation of isotype switching(GO:0045829) negative regulation of isotype switching to IgE isotypes(GO:0048294)
0.0	0.1	GO:1903061	positive regulation of protein lipidation(GO:1903061)
0.0	0.0	GO:0018992	germ-line sex determination(GO:0018992)
0.0	0.1	GO:0000965	mitochondrial RNA 3'-end processing(GO:0000965)
0.0	0.1	GO:0070213	protein auto-ADP-ribosylation(GO:0070213)
0.0	0.1	GO:1901660	calcium ion export(GO:1901660)
0.0	0.0	GO:0060397	JAK-STAT cascade involved in growth hormone signaling pathway(GO:0060397)
0.0	0.0	GO:0043490	malate-aspartate shuttle(GO:0043490)
0.0	0.1	GO:1902309	negative regulation of peptidyl-serine dephosphorylation(GO:1902309)
0.0	0.1	GO:0006741	NADP biosynthetic process(GO:0006741)
0.0	0.0	GO:0086073	bundle of His cell-Purkinje myocyte adhesion involved in cell communication(GO:0086073)
0.0	0.1	GO:1902902	negative regulation of autophagosome assembly(GO:1902902)
0.0	0.1	GO:0051295	establishment of meiotic spindle localization(GO:0051295)
0.0	0.1	GO:0035864	response to potassium ion(GO:0035864) cellular response to potassium ion(GO:0035865)
0.0	0.0	GO:0072092	ureteric bud invasion(GO:0072092)
0.0	0.0	GO:0051365	cellular response to potassium ion starvation(GO:0051365)
0.0	0.1	GO:0002051	osteoblast fate commitment(GO:0002051)
0.0	0.1	GO:0045647	negative regulation of erythrocyte differentiation(GO:0045647)
0.0	0.2	GO:0071364	response to epidermal growth factor(GO:0070849) cellular response to epidermal growth factor stimulus(GO:0071364)
0.0	0.1	GO:0060319	primitive erythrocyte differentiation(GO:0060319)
0.0	0.0	GO:0051599	response to hydrostatic pressure(GO:0051599)
0.0	0.0	GO:0042851	L-alanine metabolic process(GO:0042851)
0.0	0.0	GO:0003162	atrioventricular node development(GO:0003162)
0.0	0.0	GO:0034197	acylglycerol transport(GO:0034196) triglyceride transport(GO:0034197)
0.0	0.1	GO:0048386	positive regulation of retinoic acid receptor signaling pathway(GO:0048386)
0.0	0.1	GO:0039536	negative regulation of RIG-I signaling pathway(GO:0039536)
0.0	0.1	GO:0070125	mitochondrial translational elongation(GO:0070125)
0.0	0.0	GO:0035021	negative regulation of Rac protein signal transduction(GO:0035021)
0.0	0.0	GO:0036438	maintenance of lens transparency(GO:0036438)
0.0	0.1	GO:0001561	fatty acid alpha-oxidation(GO:0001561)
0.0	0.1	GO:0018119	peptidyl-cysteine S-nitrosylation(GO:0018119)
0.0	0.0	GO:0045091	regulation of single stranded viral RNA replication via double stranded DNA intermediate(GO:0045091)
0.0	0.0	GO:2000346	negative regulation of hepatocyte proliferation(GO:2000346)
0.0	0.0	GO:0071677	positive regulation of mononuclear cell migration(GO:0071677)
0.0	0.1	GO:0060591	chondroblast differentiation(GO:0060591)
0.0	0.1	GO:0006848	pyruvate transport(GO:0006848)
0.0	0.0	GO:0034146	toll-like receptor 5 signaling pathway(GO:0034146)
0.0	0.0	GO:0045079	negative regulation of chemokine biosynthetic process(GO:0045079)
0.0	0.1	GO:0060373	regulation of ventricular cardiac muscle cell membrane depolarization(GO:0060373)
0.0	0.1	GO:0009650	UV protection(GO:0009650)
0.0	0.1	GO:1903799	negative regulation of production of miRNAs involved in gene silencing by miRNA(GO:1903799)
0.0	0.0	GO:0001951	intestinal D-glucose absorption(GO:0001951)
0.0	0.1	GO:0030091	protein repair(GO:0030091)
0.0	0.0	GO:0018125	peptidyl-cysteine methylation(GO:0018125)
0.0	0.1	GO:0045039	protein import into mitochondrial inner membrane(GO:0045039)
0.0	0.0	GO:2000587	regulation of platelet-derived growth factor receptor-beta signaling pathway(GO:2000586) negative regulation of platelet-derived growth factor receptor-beta signaling pathway(GO:2000587)
0.0	0.1	GO:0006107	oxaloacetate metabolic process(GO:0006107)
0.0	0.0	GO:0042758	long-chain fatty acid catabolic process(GO:0042758)
0.0	0.0	GO:2001137	positive regulation of endocytic recycling(GO:2001137)
0.0	0.0	GO:0061146	Peyer's patch morphogenesis(GO:0061146)
0.0	0.0	GO:0001922	B-1 B cell homeostasis(GO:0001922)
0.0	0.1	GO:0006451	selenocysteine incorporation(GO:0001514) translational readthrough(GO:0006451)
0.0	0.0	GO:0070858	negative regulation of bile acid biosynthetic process(GO:0070858) negative regulation of bile acid metabolic process(GO:1904252)
0.0	0.1	GO:0071557	histone H3-K27 demethylation(GO:0071557)
0.0	0.1	GO:0021764	amygdala development(GO:0021764)
0.0	0.1	GO:0006528	asparagine metabolic process(GO:0006528)
0.0	0.1	GO:0006048	UDP-N-acetylglucosamine biosynthetic process(GO:0006048)
0.0	0.1	GO:0015879	carnitine transport(GO:0015879)
0.0	0.0	GO:1904714	regulation of chaperone-mediated autophagy(GO:1904714)
0.0	0.1	GO:0035518	histone H2A monoubiquitination(GO:0035518)
0.0	0.1	GO:0006120	mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.0	0.0	GO:0017187	peptidyl-glutamic acid carboxylation(GO:0017187)
0.0	0.0	GO:0036091	positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress(GO:0036091)
0.0	0.0	GO:0071288	cellular response to mercury ion(GO:0071288)
0.0	0.1	GO:0002934	desmosome organization(GO:0002934)
0.0	0.0	GO:0097067	cellular response to thyroid hormone stimulus(GO:0097067)
0.0	0.0	GO:0044828	negative regulation by host of viral genome replication(GO:0044828)
0.0	0.1	GO:1904262	negative regulation of TORC1 signaling(GO:1904262)
0.0	0.0	GO:1902268	negative regulation of polyamine transmembrane transport(GO:1902268)
0.0	0.0	GO:1904694	negative regulation of vascular smooth muscle contraction(GO:1904694)
0.0	0.0	GO:0071139	resolution of recombination intermediates(GO:0071139)
0.0	0.0	GO:1990036	calcium ion import into sarcoplasmic reticulum(GO:1990036)

Gene overrepresentation in cellular component category:

Total log-likelihood	Term	Description
0.2	GO:0005726	perichromatin fibrils(GO:0005726)
0.1	GO:0071664	catenin-TCF7L2 complex(GO:0071664)
0.1	GO:0072487	MSL complex(GO:0072487)
0.2	GO:0044613	nuclear pore central transport channel(GO:0044613)
0.1	GO:0036488	CHOP-C/EBP complex(GO:0036488)
0.1	GO:0097487	multivesicular body, internal vesicle(GO:0097487)
0.1	GO:0016939	kinesin II complex(GO:0016939)
0.1	GO:0097427	microtubule bundle(GO:0097427)
0.1	GO:0044611	nuclear pore inner ring(GO:0044611)
0.2	GO:0030056	hemidesmosome(GO:0030056)
0.1	GO:0070876	SOSS complex(GO:0070876)
0.2	GO:0016342	catenin complex(GO:0016342)
0.1	GO:0097452	GAIT complex(GO:0097452)
0.1	GO:0097629	extrinsic component of omegasome membrane(GO:0097629)
0.1	GO:0048476	Holliday junction resolvase complex(GO:0048476)
0.1	GO:0014731	spectrin-associated cytoskeleton(GO:0014731)
0.1	GO:0042719	mitochondrial intermembrane space protein transporter complex(GO:0042719)
0.1	GO:0005826	actomyosin contractile ring(GO:0005826)
0.1	GO:0000796	condensin complex(GO:0000796)
0.1	GO:0045298	tubulin complex(GO:0045298)
0.0	GO:0002193	MAML1-RBP-Jkappa- ICN1 complex(GO:0002193)
0.1	GO:0001739	sex chromatin(GO:0001739)
0.0	GO:0020016	ciliary pocket(GO:0020016) ciliary pocket membrane(GO:0020018)
0.0	GO:0031088	platelet dense granule membrane(GO:0031088)
0.1	GO:0032039	integrator complex(GO:0032039)
0.1	GO:0032593	insulin-responsive compartment(GO:0032593)
0.1	GO:0016012	sarcoglycan complex(GO:0016012)
0.1	GO:0034518	mRNA cap binding complex(GO:0005845) RNA cap binding complex(GO:0034518)
0.0	GO:0000931	gamma-tubulin large complex(GO:0000931) gamma-tubulin ring complex(GO:0008274)
0.0	GO:0071203	WASH complex(GO:0071203)
0.0	GO:0016602	CCAAT-binding factor complex(GO:0016602)
0.0	GO:1990635	proximal dendrite(GO:1990635)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	0.7	GO:0042731	PH domain binding(GO:0042731)
0.1	0.2	GO:0071535	RING-like zinc finger domain binding(GO:0071535)
0.1	0.3	GO:0034714	type III transforming growth factor beta receptor binding(GO:0034714)
0.1	0.2	GO:0016531	copper chaperone activity(GO:0016531)
0.1	0.2	GO:0015186	L-asparagine transmembrane transporter activity(GO:0015182) L-glutamine transmembrane transporter activity(GO:0015186)
0.1	0.2	GO:0004103	choline kinase activity(GO:0004103)
0.1	0.2	GO:0004069	L-aspartate:2-oxoglutarate aminotransferase activity(GO:0004069)
0.0	0.3	GO:0004768	stearoyl-CoA 9-desaturase activity(GO:0004768)
0.0	0.2	GO:0034056	estrogen response element binding(GO:0034056)
0.0	0.1	GO:0004096	catalase activity(GO:0004096)
0.0	0.1	GO:0034235	GPI anchor binding(GO:0034235)
0.0	0.4	GO:0001222	transcription corepressor binding(GO:0001222)
0.0	0.1	GO:0005006	epidermal growth factor-activated receptor activity(GO:0005006)
0.0	0.1	GO:0004365	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity(GO:0004365) glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity(GO:0043891)
0.0	0.1	GO:0004687	myosin light chain kinase activity(GO:0004687)
0.0	0.1	GO:0005220	inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.0	0.1	GO:0042979	ornithine decarboxylase regulator activity(GO:0042979)
0.0	0.1	GO:0008821	crossover junction endodeoxyribonuclease activity(GO:0008821)
0.0	0.1	GO:0047760	butyrate-CoA ligase activity(GO:0047760)
0.0	0.2	GO:0048027	mRNA 5'-UTR binding(GO:0048027)
0.0	0.1	GO:0000403	Y-form DNA binding(GO:0000403)
0.0	0.1	GO:0005168	neurotrophin TRKA receptor binding(GO:0005168)
0.0	0.1	GO:0008526	phosphatidylinositol transporter activity(GO:0008526)
0.0	0.1	GO:0046790	virion binding(GO:0046790)
0.0	0.1	GO:0008597	calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597)
0.0	0.1	GO:0004505	phenylalanine 4-monooxygenase activity(GO:0004505)
0.0	0.1	GO:0004839	ubiquitin activating enzyme activity(GO:0004839)
0.0	0.0	GO:0034648	histone demethylase activity (H3-dimethyl-K4 specific)(GO:0034648)
0.0	0.1	GO:1990254	keratin filament binding(GO:1990254)
0.0	0.1	GO:0008486	diphosphoinositol-polyphosphate diphosphatase activity(GO:0008486)
0.0	0.1	GO:0043426	MRF binding(GO:0043426)
0.0	0.1	GO:0042030	ATPase inhibitor activity(GO:0042030)
0.0	0.1	GO:0004719	protein-L-isoaspartate (D-aspartate) O-methyltransferase activity(GO:0004719)
0.0	0.1	GO:0045134	uridine-diphosphatase activity(GO:0045134)
0.0	0.1	GO:0030235	nitric-oxide synthase regulator activity(GO:0030235)
0.0	0.2	GO:0005388	calcium-transporting ATPase activity(GO:0005388)
0.0	0.1	GO:0008532	N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity(GO:0008532)
0.0	0.1	GO:1990239	steroid hormone binding(GO:1990239)
0.0	0.0	GO:0016822	hydrolase activity, acting on acid carbon-carbon bonds(GO:0016822) hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances(GO:0016823)
0.0	0.1	GO:0015288	porin activity(GO:0015288)
0.0	0.1	GO:0051425	PTB domain binding(GO:0051425)
0.0	0.0	GO:0060230	lipoprotein lipase activator activity(GO:0060230)
0.0	0.1	GO:0005007	fibroblast growth factor-activated receptor activity(GO:0005007)
0.0	0.0	GO:0019788	NEDD8 transferase activity(GO:0019788)
0.0	0.1	GO:0008190	eukaryotic initiation factor 4E binding(GO:0008190)
0.0	0.2	GO:0005247	voltage-gated chloride channel activity(GO:0005247)
0.0	0.2	GO:0030676	Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0	0.0	GO:0034186	apolipoprotein A-I binding(GO:0034186)
0.0	0.1	GO:0015226	amino-acid betaine transmembrane transporter activity(GO:0015199) carnitine transmembrane transporter activity(GO:0015226)
0.0	0.1	GO:0003847	1-alkyl-2-acetylglycerophosphocholine esterase activity(GO:0003847)
0.0	0.4	GO:0030507	spectrin binding(GO:0030507)
0.0	0.2	GO:0008307	structural constituent of muscle(GO:0008307)
0.0	0.1	GO:0071558	histone demethylase activity (H3-K27 specific)(GO:0071558)
0.0	0.1	GO:0005068	transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
0.0	0.0	GO:0031826	type 2A serotonin receptor binding(GO:0031826)
0.0	0.2	GO:0035259	glucocorticoid receptor binding(GO:0035259)
0.0	0.1	GO:0035184	histone threonine kinase activity(GO:0035184)
0.0	0.0	GO:0004924	oncostatin-M receptor activity(GO:0004924)
0.0	0.0	GO:0015440	peptide-transporting ATPase activity(GO:0015440)
0.0	0.1	GO:0003836	beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.0	0.1	GO:0005315	inorganic phosphate transmembrane transporter activity(GO:0005315)
0.0	0.1	GO:0017166	vinculin binding(GO:0017166)
0.0	0.4	GO:0015485	cholesterol binding(GO:0015485)
0.0	0.1	GO:0043495	protein anchor(GO:0043495)
0.0	0.0	GO:0008865	fructokinase activity(GO:0008865) mannokinase activity(GO:0019158)
0.0	0.1	GO:0050815	phosphoserine binding(GO:0050815)
0.0	0.1	GO:0070728	leucine binding(GO:0070728)
0.0	0.0	GO:0015143	urate transmembrane transporter activity(GO:0015143) salt transmembrane transporter activity(GO:1901702)
0.0	0.1	GO:0033677	DNA/RNA helicase activity(GO:0033677)
0.0	0.1	GO:0008312	7S RNA binding(GO:0008312)
0.0	0.0	GO:0016212	kynurenine-oxoglutarate transaminase activity(GO:0016212) kynurenine aminotransferase activity(GO:0036137)
0.0	0.0	GO:0033142	progesterone receptor binding(GO:0033142)
0.0	0.0	GO:0000340	RNA 7-methylguanosine cap binding(GO:0000340)
0.0	0.1	GO:0017056	structural constituent of nuclear pore(GO:0017056)
0.0	0.1	GO:0005072	transforming growth factor beta receptor, cytoplasmic mediator activity(GO:0005072)

Gene overrepresentation in curated gene sets: canonical pathways category:

Total log-likelihood	Term	Description
0.5	PID CIRCADIAN PATHWAY	Circadian rhythm pathway
0.1	PID PDGFRA PATHWAY	PDGFR-alpha signaling pathway
0.2	PID TCR RAS PATHWAY	Ras signaling in the CD4+ TCR pathway
0.2	SA MMP CYTOKINE CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.3	PID ECADHERIN KERATINOCYTE PATHWAY	E-cadherin signaling in keratinocytes
0.0	PID PS1 PATHWAY	Presenilin action in Notch and Wnt signaling
0.6	PID AR TF PATHWAY	Regulation of Androgen receptor activity
0.0	PID P38 MK2 PATHWAY	p38 signaling mediated by MAPKAP kinases
0.2	PID PRL SIGNALING EVENTS PATHWAY	Signaling events mediated by PRL

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Total log-likelihood	Term	Description
0.1	REACTOME SHC1 EVENTS IN EGFR SIGNALING	Genes involved in SHC1 events in EGFR signaling
0.3	REACTOME ALPHA LINOLENIC ACID ALA METABOLISM	Genes involved in alpha-linolenic acid (ALA) metabolism
0.2	REACTOME RAF MAP KINASE CASCADE	Genes involved in RAF/MAP kinase cascade
0.3	REACTOME SIGNALING BY FGFR1 FUSION MUTANTS	Genes involved in Signaling by FGFR1 fusion mutants
0.4	REACTOME RORA ACTIVATES CIRCADIAN EXPRESSION	Genes involved in RORA Activates Circadian Expression
0.2	REACTOME SYNTHESIS OF PE	Genes involved in Synthesis of PE
0.2	REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION	Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.2	REACTOME PURINE CATABOLISM	Genes involved in Purine catabolism
0.0	REACTOME CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION	Genes involved in Cyclin E associated events during G1/S transition
0.2	REACTOME REGULATION OF SIGNALING BY CBL	Genes involved in Regulation of signaling by CBL
0.1	REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK	Genes involved in Negative regulation of the PI3K/AKT network
0.2	REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS	Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.1	REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS	Genes involved in Apoptotic cleavage of cellular proteins
0.2	REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION	Genes involved in Amino acid synthesis and interconversion (transamination)
0.1	REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE	Genes involved in Synthesis of PIPs at the early endosome membrane
0.2	REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION	Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription