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ENCSR904DTN: DNase-seq of mouse liver in constant darkness

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for Zfp423

Z-value: 1.31

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Transcription factors associated with Zfp423

Gene Symbol	Gene ID	Gene Info
Zfp423 Ensembl NCBI MGI UniProt	ENSMUSG00000045333.9	Zfp423

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

Gene	Promoter	Distance	Association probability	Pearson corr. coef.	P-value	Plot
Zfp423	chr8_87958728_87958915	774	0.739801	0.88	1.9e-02	Click!
Zfp423	chr8_87961136_87961302	1624	0.480154	0.66	1.6e-01	Click!
Zfp423	chr8_87958522_87958673	998	0.651721	0.64	1.7e-01	Click!
Zfp423	chr8_87967436_87967595	7920	0.261592	-0.49	3.2e-01	Click!
Zfp423	chr8_87928980_87929146	14989	0.257222	-0.47	3.5e-01	Click!

Activity of the Zfp423 motif across conditions

Conditions sorted by the z-value of the Zfp423 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr9_118232810_118233328	1.28	Gm17399	predicted gene, 17399	82838	0.08
chr9_122056710_122056883	0.84	Gm39465	predicted gene, 39465	5333	0.13
chr6_72607554_72607726	0.66	Retsat	retinol saturase (all trans retinol 13,14 reductase)	995	0.29
chr7_24595623_24595793	0.65	Zfp575	zinc finger protein 575	8067	0.08
chr12_46819464_46819646	0.62	Nova1	NOVA alternative splicing regulator 1	626	0.75
chr1_90914963_90915133	0.61	Mlph	melanophilin	37	0.97
chr9_119145447_119145657	0.60	Acaa1b	acetyl-Coenzyme A acyltransferase 1B	4511	0.13
chr14_19712945_19713096	0.60	Gm49341	predicted gene, 49341	15811	0.12
chr17_56206282_56206453	0.58	Dpp9	dipeptidylpeptidase 9	2841	0.13
chr6_54699097_54699279	0.57	Gm44008	predicted gene, 44008	5542	0.18
chr4_138367286_138367444	0.57	Cda	cytidine deaminase	627	0.6
chr6_121329747_121329921	0.56	Gm24855	predicted gene, 24855	4158	0.18
chr11_75443489_75443686	0.54	Serpinf2	serine (or cysteine) peptidase inhibitor, clade F, member 2	3996	0.09
chr5_114146641_114146865	0.52	Acacb	acetyl-Coenzyme A carboxylase beta	218	0.89
chr6_59456281_59456457	0.52	Gprin3	GPRIN family member 3	30075	0.25
chr17_53627390_53627541	0.50	Kat2b	K(lysine) acetyltransferase 2B	17232	0.14
chr12_31074210_31074363	0.50	Fam110c	family with sequence similarity 110, member C	425	0.77
chr2_6124892_6125054	0.46	Proser2	proline and serine rich 2	5166	0.17
chr16_12924383_12924551	0.44	4930414F18Rik	RIKEN cDNA 4930414F18 gene	21468	0.21
chr6_72120521_72121047	0.44	4933431G14Rik	RIKEN cDNA 4933431G14 gene	2156	0.2
chr16_30266715_30266896	0.42	Cpn2	carboxypeptidase N, polypeptide 2	694	0.61
chr13_29759437_29759751	0.42	Cdkal1	CDK5 regulatory subunit associated protein 1-like 1	95837	0.09
chr7_75852547_75852704	0.41	Klhl25	kelch-like 25	4184	0.26
chr18_38923142_38923385	0.41	Fgf1	fibroblast growth factor 1	4492	0.24
chr2_178631647_178631798	0.41	Cdh26	cadherin-like 26	171092	0.03
chr10_82804895_82805071	0.40	1700028I16Rik	RIKEN cDNA 1700028I16 gene	7140	0.13
chr12_41247016_41247167	0.40	Gm47376	predicted gene, 47376	100999	0.07
chr7_39967880_39968059	0.39	Gm44992	predicted gene 44992	10105	0.24
chr11_44002192_44002372	0.38	Gm12153	predicted gene 12153	43193	0.18
chr7_118580172_118580323	0.38	Tmc7	transmembrane channel-like gene family 7	4439	0.17
chr18_82674862_82675025	0.38	Zfp236	zinc finger protein 236	8625	0.11
chr17_26505091_26505576	0.38	Gm34455	predicted gene, 34455	2133	0.18
chr17_29058763_29058940	0.37	Gm41556	predicted gene, 41556	622	0.52
chr16_25059586_25059982	0.37	A230028O05Rik	RIKEN cDNA A230028O05 gene	145	0.98
chr4_129672269_129672601	0.37	Kpna6	karyopherin (importin) alpha 6	93	0.94
chr12_17473483_17473634	0.37	Gm36752	predicted gene, 36752	36940	0.13
chr17_32482095_32482423	0.37	Cyp4f39	cytochrome P450, family 4, subfamily f, polypeptide 39	4008	0.16
chr2_31462375_31462570	0.37	Ass1	argininosuccinate synthetase 1	7735	0.19
chr1_93136180_93136798	0.36	Agxt	alanine-glyoxylate aminotransferase	921	0.46
chr1_172141858_172142009	0.36	Gm10171	predicted gene 10171	2968	0.14
chr7_113210463_113210620	0.36	Arntl	aryl hydrocarbon receptor nuclear translocator-like	2984	0.29
chr11_79992533_79993138	0.35	Suz12	SUZ12 polycomb repressive complex 2 subunit	271	0.91
chr15_6626042_6626459	0.35	Fyb	FYN binding protein	6656	0.2
chr7_25317114_25317265	0.35	Megf8	multiple EGF-like-domains 8	25	0.95
chr4_135961065_135961216	0.35	Hmgcl	3-hydroxy-3-methylglutaryl-Coenzyme A lyase	808	0.4
chr7_19748516_19748701	0.34	Nectin2	nectin cell adhesion molecule 2	925	0.32
chr15_83857228_83857398	0.33	Mpped1	metallophosphoesterase domain containing 1	21273	0.19
chr11_63891944_63892129	0.33	Hs3st3b1	heparan sulfate (glucosamine) 3-O-sulfotransferase 3B1	30254	0.17
chr9_20868532_20868915	0.32	Shfl	shiftless antiviral inhibitor of ribosomal frameshifting	43	0.94
chr2_94406371_94406538	0.32	Ttc17	tetratricopeptide repeat domain 17	225	0.58
chr15_85935281_85935435	0.31	Celsr1	cadherin, EGF LAG seven-pass G-type receptor 1	12936	0.17
chr18_31642183_31642334	0.31	Sap130	Sin3A associated protein	7079	0.18
chr12_103148529_103148680	0.31	Unc79	unc-79 homolog	14063	0.2
chr19_46659862_46660079	0.31	Gm36602	predicted gene, 36602	6156	0.13
chr3_41491371_41491522	0.30	Platr4	pluripotency associated transcript 4	1744	0.27
chr7_143053595_143053746	0.30	R74862	expressed sequence R74862	7	0.86
chr12_17852257_17852416	0.30	Gm49326	predicted gene, 49326	29861	0.12
chrX_8206941_8207115	0.29	Porcn	porcupine O-acyltransferase	503	0.68
chr19_38124006_38124436	0.29	Rbp4	retinol binding protein 4, plasma	504	0.74
chr15_39870319_39870474	0.28	Dpys	dihydropyrimidinase	12926	0.21
chr6_39241464_39242040	0.28	Gm43479	predicted gene 43479	1638	0.32
chr10_75067635_75067786	0.28	Bcr	BCR activator of RhoGEF and GTPase	7118	0.18
chr5_30423662_30423825	0.28	Otof	otoferlin	15682	0.15
chr17_56111930_56112088	0.28	Plin4	perilipin 4	2206	0.14
chr10_77021731_77021886	0.28	Gm3137	predicted gene, 3137	7767	0.12
chr4_133633685_133634017	0.27	Zdhhc18	zinc finger, DHHC domain containing 18	382	0.77
chr17_8801315_8801513	0.27	Pde10a	phosphodiesterase 10A	279	0.94
chr7_98119476_98119911	0.27	Myo7a	myosin VIIA	169	0.95
chr11_69802912_69803071	0.27	Fgf11	fibroblast growth factor 11	1134	0.19
chr9_104042276_104042447	0.27	Gm28305	predicted gene 28305	1699	0.18
chr14_17753703_17753909	0.26	Gm48320	predicted gene, 48320	17316	0.27
chr4_126115280_126115448	0.26	Stk40	serine/threonine kinase 40	2908	0.15
chr4_138348053_138348212	0.25	Cda	cytidine deaminase	4483	0.13
chr1_53296592_53296800	0.25	Pms1	PMS1 homolog 1, mismatch repair system component	271	0.46
chr17_29073166_29073338	0.25	Trp53cor1	tumor protein p53 pathway corepressor 1	347	0.75
chr8_121620520_121620873	0.25	Zcchc14	zinc finger, CCHC domain containing 14	7914	0.12
chr12_111759014_111759441	0.25	Klc1	kinesin light chain 1	214	0.89
chr17_34742637_34742870	0.25	C4b	complement component 4B (Chido blood group)	1129	0.24
chr3_121531769_121531936	0.25	A530020G20Rik	RIKEN cDNA A530020G20 gene	173	0.82
chr3_104780962_104781128	0.24	Ppm1j	protein phosphatase 1J	11	0.92
chr10_78482196_78482378	0.24	Gm30232	predicted gene, 30232	1308	0.21
chr10_80448589_80448759	0.24	Tcf3	transcription factor 3	15027	0.08
chr2_154398565_154398783	0.24	Snta1	syntrophin, acidic 1	9306	0.16
chr4_144950062_144950271	0.23	Gm38074	predicted gene, 38074	8682	0.2
chr6_137738154_137738336	0.23	Strap	serine/threonine kinase receptor associated protein	3167	0.29
chr17_28233099_28233728	0.23	Ppard	peroxisome proliferator activator receptor delta	606	0.6
chr14_100221834_100222037	0.23	Gm16260	predicted gene 16260	2449	0.3
chr11_75165433_75165593	0.23	Hic1	hypermethylated in cancer 1	2633	0.13
chr3_95160050_95160201	0.23	Sema6c	sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6C	332	0.72
chr17_12931878_12932047	0.22	Acat3	acetyl-Coenzyme A acetyltransferase 3	4280	0.09
chr4_108780280_108780466	0.22	Zfyve9	zinc finger, FYVE domain containing 9	130	0.95
chr9_21425419_21426009	0.22	Dnm2	dynamin 2	470	0.68
chr6_124814399_124814561	0.22	Tpi1	triosephosphate isomerase 1	184	0.84
chr6_90565247_90565487	0.22	Aldh1l1	aldehyde dehydrogenase 1 family, member L1	2339	0.23
chr11_62560745_62560932	0.22	Gm12280	predicted gene 12280	5545	0.09
chr4_141546149_141546719	0.22	B330016D10Rik	RIKEN cDNA B330016D10 gene	245	0.89
chr13_73505821_73505982	0.22	Lpcat1	lysophosphatidylcholine acyltransferase 1	3040	0.27
chr4_156093629_156093788	0.22	9430015G10Rik	RIKEN cDNA 9430015G10 gene	16274	0.08
chr10_127612734_127612929	0.22	Lrp1	low density lipoprotein receptor-related protein 1	8091	0.1
chr4_45527993_45528163	0.22	Shb	src homology 2 domain-containing transforming protein B	2252	0.24
chr2_152781176_152781342	0.22	Gm23802	predicted gene, 23802	8370	0.12
chr16_13205450_13205719	0.21	Mrtfb	myocardin related transcription factor B	50897	0.15
chr11_24049318_24049496	0.21	A830031A19Rik	RIKEN cDNA A830031A19 gene	25647	0.13
chr4_129928537_129928701	0.21	Spocd1	SPOC domain containing 1	630	0.61
chr11_69580921_69581079	0.21	Trp53	transformation related protein 53	595	0.37
chr11_97803969_97804142	0.21	Lasp1	LIM and SH3 protein 1	1137	0.28
chrX_12045986_12046173	0.21	Bcor	BCL6 interacting corepressor	34474	0.19
chr13_92530147_92530703	0.21	Zfyve16	zinc finger, FYVE domain containing 16	443	0.84
chr7_101300105_101300356	0.21	Atg16l2	autophagy related 16-like 2 (S. cerevisiae)	1797	0.23
chr12_81155440_81155704	0.21	Mir3067	microRNA 3067	10579	0.22
chr11_120933043_120933238	0.21	Ccdc57	coiled-coil domain containing 57	268	0.86
chr4_150725753_150726057	0.21	Gm16079	predicted gene 16079	47113	0.13
chr6_72097199_72097385	0.21	St3gal5	ST3 beta-galactoside alpha-2,3-sialyltransferase 5	300	0.84
chr2_70538432_70538586	0.20	Gad1	glutamate decarboxylase 1	14563	0.12
chr4_133257569_133257750	0.20	Sytl1	synaptotagmin-like 1	5393	0.12
chr8_85840465_85840659	0.20	Itfg1	integrin alpha FG-GAP repeat containing 1	359	0.51
chr8_11308621_11308772	0.20	Col4a1	collagen, type IV, alpha 1	3993	0.18
chr9_63184215_63184671	0.20	Skor1	SKI family transcriptional corepressor 1	35482	0.15
chr11_94171545_94171712	0.20	B230206L02Rik	RIKEN cDNA B230206L02 gene	35968	0.13
chr1_184870102_184870490	0.20	C130074G19Rik	RIKEN cDNA C130074G19 gene	12922	0.15
chr11_101667268_101667443	0.20	Arl4d	ADP-ribosylation factor-like 4D	1814	0.19
chr2_109918614_109919408	0.20	Lgr4	leucine-rich repeat-containing G protein-coupled receptor 4	1364	0.42
chr7_44604134_44604335	0.20	Kcnc3	potassium voltage gated channel, Shaw-related subfamily, member 3	8141	0.07
chr10_81192185_81192336	0.20	Dapk3	death-associated protein kinase 3	704	0.37
chr11_78164488_78164639	0.20	Traf4	TNF receptor associated factor 4	953	0.27
chr17_36231281_36231449	0.20	Gm18604	predicted gene, 18604	1896	0.09
chr12_110207275_110207455	0.20	Gm34785	predicted gene, 34785	19304	0.11
chr4_109670382_109670535	0.20	Cdkn2c	cyclin dependent kinase inhibitor 2C	3269	0.2
chr9_106818557_106818729	0.19	Dcaf1	DDB1 and CUL4 associated factor 1	3231	0.17
chrX_8182990_8183171	0.19	Ebp	phenylalkylamine Ca2+ antagonist (emopamil) binding protein	4094	0.12
chr10_59769174_59769339	0.19	Micu1	mitochondrial calcium uptake 1	6843	0.17
chr6_124414593_124414746	0.19	Pex5	peroxisomal biogenesis factor 5	194	0.9
chr12_80325192_80325380	0.19	Dcaf5	DDB1 and CUL4 associated factor 5	51406	0.09
chr3_107631893_107632246	0.19	Strip1	striatin interacting protein 1	375	0.67
chr12_17691531_17691833	0.19	Hpcal1	hippocalcin-like 1	826	0.68
chr19_59367680_59367885	0.19	Pdzd8	PDZ domain containing 8	22002	0.13
chr7_123466413_123466584	0.19	Aqp8	aquaporin 8	2747	0.27
chr11_119089905_119090309	0.19	Cbx4	chromobox 4	3886	0.17
chr5_24652159_24652333	0.19	1700022A21Rik	RIKEN cDNA 1700022A21 gene	4562	0.13
chr12_8591645_8591809	0.19	Slc7a15	solute carrier family 7 (cationic amino acid transporter, y+ system), member 15	7339	0.21
chr12_3926230_3926408	0.19	Gm9088	predicted gene 9088	5721	0.16
chr11_120973422_120973891	0.19	Csnk1d	casein kinase 1, delta	2031	0.18
chr18_60726300_60726451	0.19	Ndst1	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1	1188	0.43
chr12_111356343_111356494	0.18	Cdc42bpb	CDC42 binding protein kinase beta	21201	0.14
chr5_143112262_143112625	0.18	Rnf216	ring finger protein 216	537	0.66
chr17_34824182_34824366	0.18	C4a	complement component 4A (Rodgers blood group)	810	0.27
chr16_38294532_38294704	0.18	Nr1i2	nuclear receptor subfamily 1, group I, member 2	206	0.92
chr9_48836587_48836813	0.18	Zbtb16	zinc finger and BTB domain containing 16	478	0.85
chr14_55899852_55900071	0.18	Sdr39u1	short chain dehydrogenase/reductase family 39U, member 1	19	0.95
chr5_103655342_103655532	0.18	1700016H13Rik	RIKEN cDNA 1700016H13 gene	286	0.86
chr9_62386066_62386269	0.18	Anp32a	acidic (leucine-rich) nuclear phosphoprotein 32 family, member A	12728	0.2
chr18_67279022_67279221	0.18	Impa2	inositol (myo)-1(or 4)-monophosphatase 2	10065	0.15
chr2_151926945_151927109	0.17	Angpt4	angiopoietin 4	15817	0.12
chr3_90231225_90231401	0.17	Jtb	jumping translocation breakpoint	284	0.78
chr3_98294775_98294926	0.17	Gm43189	predicted gene 43189	7862	0.15
chr10_80683730_80683904	0.17	Mknk2	MAP kinase-interacting serine/threonine kinase 2	5705	0.09
chr17_26504366_26504899	0.17	Gm34455	predicted gene, 34455	1432	0.26
chr9_96966105_96966535	0.17	Spsb4	splA/ryanodine receptor domain and SOCS box containing 4	5655	0.18
chr9_21239006_21239167	0.17	Keap1	kelch-like ECH-associated protein 1	7	0.95
chr1_190173088_190173263	0.17	Prox1	prospero homeobox 1	2461	0.25
chr9_85328031_85328205	0.17	Tent5a	terminal nucleotidyltransferase 5A	770	0.59
chr18_32252120_32252375	0.17	Ercc3	excision repair cross-complementing rodent repair deficiency, complementation group 3	5022	0.23
chr17_5295996_5296161	0.17	Gm29050	predicted gene 29050	92685	0.08
chr19_47338199_47338378	0.17	Sh3pxd2a	SH3 and PX domains 2A	23537	0.17
chr2_151943059_151943241	0.17	Gm14154	predicted gene 14154	7491	0.14
chr3_36483169_36483342	0.17	1810062G17Rik	RIKEN cDNA 1810062G17 gene	7318	0.12
chr1_4785233_4785557	0.16	Mrpl15	mitochondrial ribosomal protein L15	297	0.83
chr4_8754940_8755164	0.16	Chd7	chromodomain helicase DNA binding protein 7	3614	0.35
chr9_103091015_103091286	0.16	Gm47468	predicted gene, 47468	5613	0.17
chr19_28834565_28834716	0.16	Slc1a1	solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1	409	0.82
chr11_11942496_11942647	0.16	Grb10	growth factor receptor bound protein 10	3759	0.24
chr4_49509287_49509438	0.16	Baat	bile acid-Coenzyme A: amino acid N-acyltransferase	2805	0.17
chr17_26702508_26702992	0.16	Crebrf	CREB3 regulatory factor	12900	0.14
chr18_32414906_32415059	0.16	Bin1	bridging integrator 1	7348	0.18
chr11_33398787_33398953	0.16	Anp32-ps	acidic (leucine-rich) nuclear phosphoprotein 32 family, pseudogene	3604	0.26
chr12_113141793_113142049	0.16	Crip2	cysteine rich protein 2	887	0.41
chr2_118487263_118487442	0.16	Gm13983	predicted gene 13983	3175	0.2
chr1_190117117_190117268	0.16	Gm28172	predicted gene 28172	51478	0.13
chr8_119574627_119574804	0.15	Hsdl1	hydroxysteroid dehydrogenase like 1	460	0.46
chr8_13869612_13869789	0.15	Champ1	chromosome alignment maintaining phosphoprotein 1	4	0.96
chr5_89341929_89342080	0.15	Gc	vitamin D binding protein	93624	0.09
chr17_35837067_35837599	0.15	Tubb5	tubulin, beta 5 class I	273	0.75
chr19_3912063_3912250	0.15	Ndufs8	NADH:ubiquinone oxidoreductase core subunit S8	332	0.72
chr3_84345271_84345622	0.15	4930565D16Rik	RIKEN cDNA 4930565D16 gene	34475	0.17
chr2_27692549_27692919	0.15	Rxra	retinoid X receptor alpha	15472	0.24
chr8_66486288_66486439	0.15	Tma16	translation machinery associated 16	134	0.96
chr1_74723320_74723471	0.15	Cyp27a1	cytochrome P450, family 27, subfamily a, polypeptide 1	9821	0.12
chr3_88145395_88145546	0.15	Mef2d	myocyte enhancer factor 2D	2896	0.15
chr2_164785973_164786236	0.15	Snx21	sorting nexin family member 21	87	0.91
chr12_71876146_71876310	0.15	Daam1	dishevelled associated activator of morphogenesis 1	13502	0.21
chr5_111473745_111473896	0.15	Gm43119	predicted gene 43119	50231	0.12
chr7_30184282_30184433	0.15	Cox7a1	cytochrome c oxidase subunit 7A1	163	0.86
chr1_172311861_172312075	0.14	Igsf8	immunoglobulin superfamily, member 8	30	0.95
chr13_18123081_18123244	0.14	4930448F12Rik	RIKEN cDNA 4930448F12 gene	22960	0.14
chr9_66179441_66179773	0.14	Dapk2	death-associated protein kinase 2	21372	0.18
chr17_50565884_50566049	0.14	Plcl2	phospholipase C-like 2	41028	0.2
chr12_31655019_31655182	0.14	Cog5	component of oligomeric golgi complex 5	231	0.54
chr12_31074834_31075017	0.14	Fam110c	family with sequence similarity 110, member C	1064	0.41
chr19_6995428_6995936	0.14	Nudt22	nudix (nucleoside diphosphate linked moiety X)-type motif 22	355	0.48
chr9_45412427_45412583	0.14	Gm48135	predicted gene, 48135	1585	0.27

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of Zfp423

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.4	GO:0009972	cytidine catabolic process(GO:0006216) cytidine deamination(GO:0009972) cytidine metabolic process(GO:0046087)
0.1	0.3	GO:0097155	fasciculation of sensory neuron axon(GO:0097155)
0.1	0.5	GO:0031999	negative regulation of fatty acid beta-oxidation(GO:0031999)
0.1	0.2	GO:0046865	retinol transport(GO:0034633) isoprenoid transport(GO:0046864) terpenoid transport(GO:0046865)
0.1	0.3	GO:0042518	negative regulation of tyrosine phosphorylation of Stat3 protein(GO:0042518)
0.1	0.2	GO:0090296	regulation of mitochondrial DNA replication(GO:0090296)
0.1	0.2	GO:0016561	protein import into peroxisome matrix, translocation(GO:0016561)
0.1	0.2	GO:0042908	xenobiotic transport(GO:0042908)
0.1	0.2	GO:0090403	oxidative stress-induced premature senescence(GO:0090403)
0.1	0.2	GO:1903525	regulation of membrane tubulation(GO:1903525)
0.0	0.1	GO:0042851	L-alanine metabolic process(GO:0042851)
0.0	0.1	GO:0046951	ketone body biosynthetic process(GO:0046951)
0.0	0.1	GO:0010046	response to mycotoxin(GO:0010046)
0.0	0.1	GO:0000101	sulfur amino acid transport(GO:0000101)
0.0	0.1	GO:0007084	mitotic nuclear envelope reassembly(GO:0007084)
0.0	0.2	GO:0010499	proteasomal ubiquitin-independent protein catabolic process(GO:0010499)
0.0	0.9	GO:0051875	pigment granule localization(GO:0051875)
0.0	0.1	GO:0030382	sperm mitochondrion organization(GO:0030382)
0.0	0.1	GO:2000646	positive regulation of receptor catabolic process(GO:2000646)
0.0	0.1	GO:0006295	nucleotide-excision repair, DNA incision, 3'-to lesion(GO:0006295)
0.0	0.1	GO:1901509	regulation of endothelial tube morphogenesis(GO:1901509)
0.0	0.2	GO:0051138	regulation of NK T cell differentiation(GO:0051136) positive regulation of NK T cell differentiation(GO:0051138)
0.0	0.2	GO:0046069	cGMP catabolic process(GO:0046069)
0.0	0.1	GO:0051315	attachment of mitotic spindle microtubules to kinetochore(GO:0051315)
0.0	0.1	GO:0036151	phosphatidylcholine acyl-chain remodeling(GO:0036151)
0.0	0.1	GO:0003221	right ventricular cardiac muscle tissue morphogenesis(GO:0003221)
0.0	0.1	GO:0043415	positive regulation of skeletal muscle tissue regeneration(GO:0043415)
0.0	0.1	GO:0019859	pyrimidine nucleobase catabolic process(GO:0006208) thymine catabolic process(GO:0006210) thymine metabolic process(GO:0019859)
0.0	0.1	GO:1900060	negative regulation of ceramide biosynthetic process(GO:1900060)
0.0	0.1	GO:0035754	B cell chemotaxis(GO:0035754)
0.0	0.2	GO:0032988	ribonucleoprotein complex disassembly(GO:0032988)
0.0	0.1	GO:0055005	ventricular cardiac myofibril assembly(GO:0055005)
0.0	0.4	GO:0006607	NLS-bearing protein import into nucleus(GO:0006607)
0.0	0.0	GO:0003431	growth plate cartilage chondrocyte development(GO:0003431)
0.0	0.1	GO:0035469	determination of pancreatic left/right asymmetry(GO:0035469)
0.0	0.1	GO:1990928	response to amino acid starvation(GO:1990928)
0.0	0.1	GO:0060448	dichotomous subdivision of terminal units involved in lung branching(GO:0060448)
0.0	0.1	GO:0033299	secretion of lysosomal enzymes(GO:0033299)
0.0	0.2	GO:0006622	protein targeting to lysosome(GO:0006622)
0.0	0.1	GO:0043985	histone H4-R3 methylation(GO:0043985)
0.0	0.1	GO:0090666	scaRNA localization to Cajal body(GO:0090666)
0.0	0.1	GO:0045900	negative regulation of translational elongation(GO:0045900)
0.0	0.1	GO:1900864	mitochondrial tRNA modification(GO:0070900) mitochondrial RNA modification(GO:1900864)
0.0	0.1	GO:1900194	negative regulation of oocyte maturation(GO:1900194)
0.0	0.1	GO:0072282	metanephric nephron tubule morphogenesis(GO:0072282)
0.0	0.1	GO:0018076	N-terminal peptidyl-lysine acetylation(GO:0018076)
0.0	0.0	GO:0018199	peptidyl-glutamine modification(GO:0018199)
0.0	0.0	GO:0035771	interleukin-4-mediated signaling pathway(GO:0035771)
0.0	0.0	GO:0071798	response to prostaglandin D(GO:0071798) cellular response to prostaglandin D stimulus(GO:0071799)
0.0	0.1	GO:0042940	D-amino acid transport(GO:0042940)
0.0	0.1	GO:0002756	MyD88-independent toll-like receptor signaling pathway(GO:0002756)
0.0	0.0	GO:0032074	negative regulation of nuclease activity(GO:0032074)
0.0	0.2	GO:0007183	SMAD protein complex assembly(GO:0007183)
0.0	0.0	GO:1902956	regulation of mitochondrial electron transport, NADH to ubiquinone(GO:1902956)
0.0	0.0	GO:0060800	regulation of cell differentiation involved in embryonic placenta development(GO:0060800)
0.0	0.0	GO:0046121	deoxyribonucleoside catabolic process(GO:0046121)
0.0	0.0	GO:0016259	selenocysteine metabolic process(GO:0016259)
0.0	0.1	GO:0016557	peroxisome membrane biogenesis(GO:0016557)
0.0	0.0	GO:1901069	guanosine-containing compound catabolic process(GO:1901069)
0.0	0.0	GO:0072386	plus-end-directed vesicle transport along microtubule(GO:0072383) plus-end-directed organelle transport along microtubule(GO:0072386)
0.0	0.0	GO:0046208	spermine catabolic process(GO:0046208)
0.0	0.1	GO:0034653	diterpenoid catabolic process(GO:0016103) retinoic acid catabolic process(GO:0034653)
0.0	0.1	GO:0006729	tetrahydrobiopterin biosynthetic process(GO:0006729)
0.0	0.0	GO:0071787	endoplasmic reticulum tubular network assembly(GO:0071787)
0.0	0.1	GO:2000169	regulation of peptidyl-cysteine S-nitrosylation(GO:2000169)
0.0	0.0	GO:0007039	protein catabolic process in the vacuole(GO:0007039)
0.0	0.2	GO:0046174	polyol catabolic process(GO:0046174)
0.0	0.0	GO:1990036	calcium ion import into sarcoplasmic reticulum(GO:1990036)
0.0	0.0	GO:0009449	gamma-aminobutyric acid biosynthetic process(GO:0009449)
0.0	0.0	GO:0044034	negative stranded viral RNA replication(GO:0039689) multi-organism biosynthetic process(GO:0044034)
0.0	0.0	GO:0036444	calcium ion transmembrane import into mitochondrion(GO:0036444)
0.0	0.1	GO:0031033	myosin filament organization(GO:0031033)
0.0	0.1	GO:0018206	peptidyl-methionine modification(GO:0018206)
0.0	0.0	GO:1900169	regulation of glucocorticoid mediated signaling pathway(GO:1900169)
0.0	0.1	GO:0060978	angiogenesis involved in coronary vascular morphogenesis(GO:0060978)
0.0	0.0	GO:0001994	norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure(GO:0001994)
0.0	0.0	GO:1902564	negative regulation of neutrophil activation(GO:1902564)
0.0	0.0	GO:0060988	lipid tube assembly(GO:0060988)
0.0	0.2	GO:0001574	ganglioside biosynthetic process(GO:0001574)
0.0	0.0	GO:0051572	negative regulation of histone H3-K4 methylation(GO:0051572)
0.0	0.1	GO:0070813	hydrogen sulfide metabolic process(GO:0070813)
0.0	0.1	GO:0008295	spermidine biosynthetic process(GO:0008295)
0.0	0.0	GO:2000586	regulation of platelet-derived growth factor receptor-beta signaling pathway(GO:2000586) negative regulation of platelet-derived growth factor receptor-beta signaling pathway(GO:2000587)
0.0	0.0	GO:0070164	negative regulation of adiponectin secretion(GO:0070164)
0.0	0.0	GO:2000574	regulation of microtubule motor activity(GO:2000574)
0.0	0.0	GO:0003219	cardiac right ventricle formation(GO:0003219)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:0016461	unconventional myosin complex(GO:0016461)
0.1	0.3	GO:0001739	sex chromatin(GO:0001739)
0.0	0.1	GO:0005712	chiasma(GO:0005712)
0.0	0.1	GO:0000110	nucleotide-excision repair factor 1 complex(GO:0000110)
0.0	0.1	GO:0034365	discoidal high-density lipoprotein particle(GO:0034365)
0.0	0.6	GO:0035371	microtubule plus-end(GO:0035371)
0.0	0.1	GO:0045298	tubulin complex(GO:0045298)
0.0	0.3	GO:0035253	ciliary rootlet(GO:0035253)
0.0	0.1	GO:0005784	Sec61 translocon complex(GO:0005784) translocon complex(GO:0071256)
0.0	0.1	GO:0097543	ciliary inversin compartment(GO:0097543)
0.0	0.1	GO:0035339	SPOTS complex(GO:0035339)
0.0	0.1	GO:0005964	phosphorylase kinase complex(GO:0005964)
0.0	0.3	GO:0005782	peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.0	0.0	GO:0046691	intracellular canaliculus(GO:0046691)
0.0	0.1	GO:0032777	Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.0	0.1	GO:0072669	tRNA-splicing ligase complex(GO:0072669)
0.0	0.1	GO:0097425	smooth endoplasmic reticulum membrane(GO:0030868) smooth endoplasmic reticulum part(GO:0097425)
0.0	0.0	GO:0097149	centralspindlin complex(GO:0097149)
0.0	0.1	GO:0070852	cell body fiber(GO:0070852)
0.0	0.1	GO:0070652	HAUS complex(GO:0070652)
0.0	0.2	GO:0001891	phagocytic cup(GO:0001891)
0.0	0.1	GO:0005915	zonula adherens(GO:0005915)
0.0	0.2	GO:0033391	chromatoid body(GO:0033391)
0.0	0.0	GO:0048787	presynaptic active zone membrane(GO:0048787)
0.0	0.0	GO:0035363	histone locus body(GO:0035363)
0.0	0.3	GO:0031901	early endosome membrane(GO:0031901)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.5	GO:0009374	biotin binding(GO:0009374)
0.1	0.4	GO:0004126	cytidine deaminase activity(GO:0004126)
0.1	0.6	GO:0051010	microtubule plus-end binding(GO:0051010)
0.0	0.2	GO:0000268	peroxisome targeting sequence binding(GO:0000268)
0.0	0.1	GO:0005332	gamma-aminobutyric acid:sodium symporter activity(GO:0005332)
0.0	0.1	GO:0017162	aryl hydrocarbon receptor binding(GO:0017162)
0.0	0.2	GO:0003836	beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.0	0.1	GO:0043423	3-phosphoinositide-dependent protein kinase binding(GO:0043423)
0.0	0.1	GO:0016833	oxo-acid-lyase activity(GO:0016833)
0.0	0.1	GO:0000099	sulfur amino acid transmembrane transporter activity(GO:0000099)
0.0	0.1	GO:0070326	very-low-density lipoprotein particle receptor binding(GO:0070326)
0.0	0.2	GO:0031749	D2 dopamine receptor binding(GO:0031749)
0.0	0.1	GO:0048408	epidermal growth factor binding(GO:0048408)
0.0	0.3	GO:0030898	actin-dependent ATPase activity(GO:0030898)
0.0	0.1	GO:0043398	HLH domain binding(GO:0043398)
0.0	0.1	GO:0070644	vitamin D response element binding(GO:0070644)
0.0	0.2	GO:0016861	intramolecular oxidoreductase activity, interconverting aldoses and ketoses(GO:0016861)
0.0	0.1	GO:0005095	GTPase inhibitor activity(GO:0005095)
0.0	0.1	GO:0031800	type 3 metabotropic glutamate receptor binding(GO:0031800)
0.0	0.1	GO:1901612	cardiolipin binding(GO:1901612)
0.0	0.3	GO:0005545	1-phosphatidylinositol binding(GO:0005545)
0.0	0.3	GO:0047555	3',5'-cyclic-GMP phosphodiesterase activity(GO:0047555)
0.0	0.1	GO:0047192	1-alkylglycerophosphocholine O-acetyltransferase activity(GO:0047192)
0.0	0.1	GO:0008401	retinoic acid 4-hydroxylase activity(GO:0008401)
0.0	0.2	GO:0004955	prostaglandin receptor activity(GO:0004955)
0.0	0.1	GO:0004689	phosphorylase kinase activity(GO:0004689)
0.0	0.4	GO:0008139	nuclear localization sequence binding(GO:0008139)
0.0	0.1	GO:0001849	complement component C1q binding(GO:0001849)
0.0	0.1	GO:0035033	histone deacetylase regulator activity(GO:0035033)
0.0	0.1	GO:0003997	acyl-CoA oxidase activity(GO:0003997)
0.0	0.1	GO:0050693	LBD domain binding(GO:0050693)
0.0	0.2	GO:0016918	retinal binding(GO:0016918)
0.0	0.1	GO:0001094	TFIID-class transcription factor binding(GO:0001094)
0.0	0.0	GO:0004937	alpha1-adrenergic receptor activity(GO:0004937)
0.0	0.1	GO:0015232	heme transporter activity(GO:0015232)
0.0	0.1	GO:0047105	aminobutyraldehyde dehydrogenase activity(GO:0019145) 4-trimethylammoniobutyraldehyde dehydrogenase activity(GO:0047105)
0.0	0.1	GO:0004468	lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468)
0.0	0.1	GO:0017034	Rap guanyl-nucleotide exchange factor activity(GO:0017034)
0.0	0.1	GO:0016832	aldehyde-lyase activity(GO:0016832)
0.0	0.0	GO:0030619	U1 snRNA binding(GO:0030619)
0.0	0.1	GO:0044548	S100 protein binding(GO:0044548)
0.0	0.1	GO:0003988	acetyl-CoA C-acyltransferase activity(GO:0003988)
0.0	0.0	GO:0016174	NAD(P)H oxidase activity(GO:0016174)
0.0	0.3	GO:0043014	alpha-tubulin binding(GO:0043014)
0.0	0.0	GO:0052650	NADP-retinol dehydrogenase activity(GO:0052650)
0.0	0.3	GO:0034831	C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity(GO:0000252) mevaldate reductase activity(GO:0004495) gluconate dehydrogenase activity(GO:0008875) epoxide dehydrogenase activity(GO:0018451) 5-exo-hydroxycamphor dehydrogenase activity(GO:0018452) 2-hydroxytetrahydrofuran dehydrogenase activity(GO:0018453) acetoin dehydrogenase activity(GO:0019152) phenylcoumaran benzylic ether reductase activity(GO:0032442) D-xylose:NADP reductase activity(GO:0032866) L-arabinose:NADP reductase activity(GO:0032867) D-arabinitol dehydrogenase, D-ribulose forming (NADP+) activity(GO:0033709) (R)-(-)-1,2,3,4-tetrahydronaphthol dehydrogenase activity(GO:0034831) 3-hydroxymenthone dehydrogenase activity(GO:0034840) very long-chain-3-hydroxyacyl-CoA dehydrogenase activity(GO:0035380) (R)-2-hydroxyisocaproate dehydrogenase activity(GO:0043713) L-arabinose 1-dehydrogenase (NADP+) activity(GO:0044103) L-xylulose reductase (NAD+) activity(GO:0044105) 3-ketoglucose-reductase activity(GO:0048258) D-arabinitol dehydrogenase, D-xylulose forming (NADP+) activity(GO:0052677)
0.0	0.0	GO:0017150	tRNA dihydrouridine synthase activity(GO:0017150)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.0	PID P38 GAMMA DELTA PATHWAY	Signaling mediated by p38-gamma and p38-delta

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Total log-likelihood	Term	Description
0.4	REACTOME ACTIVATED AMPK STIMULATES FATTY ACID OXIDATION IN MUSCLE	Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle
0.2	REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA	Genes involved in Circadian Repression of Expression by REV-ERBA
0.2	REACTOME GAP JUNCTION DEGRADATION	Genes involved in Gap junction degradation
0.5	REACTOME PYRIMIDINE METABOLISM	Genes involved in Pyrimidine metabolism
0.3	REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING	Genes involved in Downregulation of TGF-beta receptor signaling
0.1	REACTOME DIGESTION OF DIETARY CARBOHYDRATE	Genes involved in Digestion of dietary carbohydrate
0.0	REACTOME PROCESSING OF CAPPED INTRONLESS PRE MRNA	Genes involved in Processing of Capped Intronless Pre-mRNA
0.0	REACTOME PYRUVATE METABOLISM AND CITRIC ACID TCA CYCLE	Genes involved in Pyruvate metabolism and Citric Acid (TCA) cycle
0.3	REACTOME KINESINS	Genes involved in Kinesins
0.2	REACTOME CGMP EFFECTS	Genes involved in cGMP effects
0.2	REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA HYDROXYCHOLESTEROL	Genes involved in Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
0.0	REACTOME DOPAMINE NEUROTRANSMITTER RELEASE CYCLE	Genes involved in Dopamine Neurotransmitter Release Cycle
0.1	REACTOME TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING	Genes involved in TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling