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ENCSR904DTN: DNase-seq of mouse liver in constant darkness

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for Zic4

Z-value: 1.81

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Transcription factors associated with Zic4

Gene Symbol	Gene ID	Gene Info
Zic4 Ensembl NCBI MGI UniProt	ENSMUSG00000036972.8	Zic4

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

Gene	Promoter	Distance	Association probability	Pearson corr. coef.	P-value	Plot
Zic4	chr9_91370473_91370649	443	0.716223	-0.27	6.0e-01	Click!
Zic4	chr9_91362060_91362437	165	0.856198	0.22	6.7e-01	Click!

Activity of the Zic4 motif across conditions

Conditions sorted by the z-value of the Zic4 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr13_60681580_60681975	5.93	Dapk1	death associated protein kinase 1	14636	0.17
chr13_60680911_60681084	1.59	Dapk1	death associated protein kinase 1	15416	0.17
chr13_60681310_60681461	1.29	Dapk1	death associated protein kinase 1	15028	0.17
chr6_72607199_72607442	1.25	Retsat	retinol saturase (all trans retinol 13,14 reductase)	675	0.43
chr13_10355578_10355729	1.18	Gm26861	predicted gene, 26861	1942	0.37
chr7_13007324_13007475	1.01	Zbtb45	zinc finger and BTB domain containing 45	2401	0.12
chr13_60682029_60682204	0.83	Dapk1	death associated protein kinase 1	14297	0.17
chr12_24651113_24651273	0.64	Klf11	Kruppel-like factor 11	81	0.96
chr6_90736325_90736476	0.63	Iqsec1	IQ motif and Sec7 domain 1	287	0.9
chr7_127804168_127804541	0.59	9430064I24Rik	RIKEN cDNA 9430064I24 gene	1592	0.16
chr11_102777578_102777754	0.57	Adam11	a disintegrin and metallopeptidase domain 11	1112	0.37
chr13_54081500_54081675	0.57	Sfxn1	sideroflexin 1	4359	0.22
chr12_84221379_84221549	0.52	Elmsan1	ELM2 and Myb/SANT-like domain containing 1	2583	0.16
chr4_144959729_144959958	0.51	Gm38074	predicted gene, 38074	995	0.56
chr4_149980056_149980645	0.51	H6pd	hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)	20915	0.13
chr7_3331834_3332020	0.50	Cacng7	calcium channel, voltage-dependent, gamma subunit 7	1028	0.31
chr1_133527738_133527935	0.50	Gm8596	predicted gene 8596	1643	0.39
chr15_67420672_67420895	0.49	1700012I11Rik	RIKEN cDNA 1700012I11 gene	194014	0.03
chr18_12644066_12644542	0.45	Gm50063	predicted gene, 50063	60	0.94
chr11_51915955_51916321	0.45	Gm39822	predicted gene, 39822	17172	0.14
chr19_6401505_6401681	0.45	Rasgrp2	RAS, guanyl releasing protein 2	102	0.92
chr17_30591215_30591503	0.45	Gm50244	predicted gene, 50244	149	0.92
chr16_10395249_10395418	0.45	Tekt5	tektin 5	115	0.96
chr9_115456234_115456417	0.45	Gm5921	predicted gene 5921	17744	0.16
chr8_123806538_123806735	0.43	Rab4a	RAB4A, member RAS oncogene family	568	0.58
chr19_47304311_47304615	0.43	Sh3pxd2a	SH3 and PX domains 2A	10288	0.16
chr18_76117628_76117791	0.43	2900057B20Rik	RIKEN cDNA 2900057B20 gene	19238	0.19
chr7_116307697_116308006	0.43	Plekha7	pleckstrin homology domain containing, family A member 7	199	0.91
chr12_102522079_102522241	0.42	Chga	chromogranin A	32809	0.12
chr5_120560470_120560640	0.42	2510016D11Rik	RIKEN cDNA 2510016D11 gene	7516	0.1
chr7_98779046_98779213	0.42	Gm44934	predicted gene 44934	44048	0.1
chr12_57575989_57576174	0.41	Ttc6	tetratricopeptide repeat domain 6	264	0.9
chr8_117747363_117747696	0.41	Gm31774	predicted gene, 31774	731	0.61
chr11_101667268_101667443	0.40	Arl4d	ADP-ribosylation factor-like 4D	1814	0.19
chr19_26733168_26733326	0.40	Smarca2	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2	3248	0.31
chr2_30966491_30966663	0.39	Tor1a	torsin family 1, member A (torsin A)	1295	0.32
chr11_116855946_116856130	0.39	Mfsd11	major facilitator superfamily domain containing 11	1960	0.2
chr19_8841055_8841224	0.38	Bscl2	Berardinelli-Seip congenital lipodystrophy 2 (seipin)	604	0.37
chr5_27677458_27677616	0.38	Paxip1	PAX interacting (with transcription-activation domain) protein 1	73758	0.1
chr11_60465981_60466150	0.38	Myo15	myosin XV	3274	0.13
chr3_97818935_97819103	0.38	Pde4dip	phosphodiesterase 4D interacting protein (myomegalin)	5602	0.23
chr19_4943305_4943466	0.38	Peli3	pellino 3	258	0.82
chr2_131910128_131910298	0.38	Prn	prion protein readthrough transcript	256	0.49
chr4_140001273_140001424	0.37	Klhdc7a	kelch domain containing 7A	33322	0.14
chr10_79616142_79616293	0.37	C2cd4c	C2 calcium-dependent domain containing 4C	2192	0.15
chr7_67061880_67062042	0.36	Adamts17	a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 17	14490	0.18
chr10_68454663_68454821	0.36	Cabcoco1	ciliary associated calcium binding coiled-coil 1	71025	0.1
chr11_113143909_113144540	0.36	2610035D17Rik	RIKEN cDNA 2610035D17 gene	28853	0.23
chr11_69605770_69605921	0.36	Atp1b2	ATPase, Na+/K+ transporting, beta 2 polypeptide	16	0.92
chr5_103693522_103693673	0.36	Aff1	AF4/FMR2 family, member 1	1223	0.43
chr2_154712310_154712496	0.36	Gm14215	predicted gene 14215	1319	0.32
chr11_78422158_78422337	0.35	Slc13a2	solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2	30	0.95
chr13_46727661_46727812	0.35	Nup153	nucleoporin 153	204	0.93
chr19_30145550_30145701	0.35	Gldc	glycine decarboxylase	394	0.86
chr11_117810052_117810409	0.34	Syngr2	synaptogyrin 2	518	0.39
chr15_88866027_88866463	0.34	Pim3	proviral integration site 3	1325	0.34
chr12_113878948_113879099	0.33	Ighv2-8	immunoglobulin heavy variable V2-8	1229	0.33
chr4_133049992_133050178	0.33	Ahdc1	AT hook, DNA binding motif, containing 1	10592	0.19
chr4_148160555_148160717	0.32	Fbxo2	F-box protein 2	15	0.65
chr8_84937365_84937533	0.32	Mast1	microtubule associated serine/threonine kinase 1	90	0.91
chr11_97434945_97435114	0.32	Arhgap23	Rho GTPase activating protein 23	1256	0.42
chr1_87041212_87041509	0.31	Gm37447	predicted gene, 37447	4637	0.13
chr11_116175159_116175523	0.31	Acox1	acyl-Coenzyme A oxidase 1, palmitoyl	5873	0.1
chr15_36471981_36472313	0.31	Ankrd46	ankyrin repeat domain 46	24568	0.12
chr13_34037312_34037494	0.31	Bphl	biphenyl hydrolase-like (serine hydrolase, breast epithelial mucin-associated antigen)	194	0.89
chr14_61680870_61681697	0.30	Gm37472	predicted gene, 37472	211	0.83
chr2_66256344_66256524	0.30	Ttc21b	tetratricopeptide repeat domain 21B	158	0.96
chr12_100343836_100343987	0.30	Ttc7b	tetratricopeptide repeat domain 7B	5615	0.19
chr19_6987284_6987440	0.30	Vegfb	vascular endothelial growth factor B	222	0.81
chr2_25262755_25263227	0.30	Tprn	taperin	373	0.59
chr19_5924482_5924697	0.30	Cdc42ep2	CDC42 effector protein (Rho GTPase binding) 2	227	0.83
chr13_119713466_119713785	0.29	Gm48342	predicted gene, 48342	9076	0.11
chr5_37717722_37717888	0.29	Stk32b	serine/threonine kinase 32B	634	0.76
chr5_110135214_110135545	0.29	Chfr	checkpoint with forkhead and ring finger domains	463	0.65
chr7_39967880_39968059	0.29	Gm44992	predicted gene 44992	10105	0.24
chr2_155053105_155053256	0.29	a	nonagouti	5565	0.16
chr8_12719084_12719404	0.28	Gm15348	predicted gene 15348	117	0.96
chr4_108217549_108217700	0.28	Zyg11a	zyg-11 family member A, cell cycle regulator	298	0.88
chr11_4098038_4098510	0.28	Mtfp1	mitochondrial fission process 1	2829	0.13
chr14_70051978_70052160	0.28	Gm33524	predicted gene, 33524	5298	0.19
chr2_167661426_167661577	0.28	Gm20431	predicted gene 20431	5	0.5
chr11_20826808_20826959	0.27	Lgalsl	lectin, galactoside binding-like	3872	0.18
chr2_32681906_32682535	0.27	Fpgs	folylpolyglutamyl synthetase	2784	0.1
chr10_88507513_88507686	0.27	Chpt1	choline phosphotransferase 1	3526	0.19
chr2_156433566_156433753	0.27	Epb41l1	erythrocyte membrane protein band 4.1 like 1	12547	0.09
chr19_5016908_5017071	0.27	Slc29a2	solute carrier family 29 (nucleoside transporters), member 2	6871	0.07
chr1_72009620_72009955	0.27	4933417E11Rik	RIKEN cDNA 4933417E11 gene	4592	0.18
chr17_12381963_12382316	0.27	Plg	plasminogen	3480	0.2
chr2_118111415_118111787	0.27	Thbs1	thrombospondin 1	275	0.6
chr19_36627251_36627417	0.27	Hectd2os	Hectd2, opposite strand	1310	0.49
chr5_111620604_111620778	0.26	Gm42489	predicted gene 42489	27075	0.18
chr6_113866107_113866258	0.26	Atp2b2	ATPase, Ca++ transporting, plasma membrane 2	25188	0.15
chr1_182620497_182620688	0.26	Capn8	calpain 8	55554	0.1
chr8_95067717_95067883	0.26	Drc7	dynein regulatory complex subunit 7	6279	0.11
chr19_8662448_8662612	0.26	9830166K06Rik	RIKEN cDNA 9830166K06 gene	805	0.34
chr6_113891432_113891618	0.25	Atp2b2	ATPase, Ca++ transporting, plasma membrane 2	14	0.98
chr12_51471684_51471879	0.25	Gm18503	predicted gene, 18503	45545	0.14
chr19_4476935_4477185	0.25	Syt12	synaptotagmin XII	66	0.96
chr7_13006960_13007136	0.25	Zbtb45	zinc finger and BTB domain containing 45	2752	0.11
chr4_138455294_138455445	0.25	Camk2n1	calcium/calmodulin-dependent protein kinase II inhibitor 1	1055	0.45
chr11_23124284_23124721	0.25	1700061J23Rik	RIKEN cDNA 1700061J23 gene	27638	0.14
chr9_53825348_53825526	0.25	Slc35f2	solute carrier family 35, member F2	14720	0.17
chr6_118478873_118479106	0.25	Zfp9	zinc finger protein 9	331	0.85
chr5_137586972_137587155	0.25	Tfr2	transferrin receptor 2	3778	0.08
chr7_25892258_25892429	0.25	Cyp2b10	cytochrome P450, family 2, subfamily b, polypeptide 10	5277	0.11
chr14_65785434_65785772	0.25	Pbk	PDZ binding kinase	20234	0.18
chr9_103471712_103471904	0.25	Gm16252	predicted gene 16252	276	0.85
chr17_31631886_31632186	0.24	Cbs	cystathionine beta-synthase	1128	0.31
chr13_119713859_119714010	0.24	Gm48342	predicted gene, 48342	9385	0.11
chr2_118883474_118883639	0.24	Ivd	isovaleryl coenzyme A dehydrogenase	7123	0.14
chr5_34636833_34637005	0.24	Mfsd10	major facilitator superfamily domain containing 10	78	0.95
chr11_87578374_87578544	0.24	Septin4	septin 4	3	0.97
chr8_84902850_84903029	0.24	Klf1	Kruppel-like factor 1 (erythroid)	1011	0.26
chr2_92383563_92383841	0.24	1700029I15Rik	RIKEN cDNA 1700029I15 gene	784	0.45
chr13_117602276_117602441	0.24	Hcn1	hyperpolarization activated cyclic nucleotide gated potassium channel 1	38	0.99
chr12_82333592_82333979	0.24	Sipa1l1	signal-induced proliferation-associated 1 like 1	8482	0.29
chr4_148903004_148903163	0.23	Casz1	castor zinc finger 1	1934	0.31
chr4_144916418_144916763	0.23	Dhrs3	dehydrogenase/reductase (SDR family) member 3	2289	0.32
chr15_101074200_101074369	0.23	Fignl2	fidgetin-like 2	4283	0.16
chr1_86415976_86416160	0.23	Nmur1	neuromedin U receptor 1	10160	0.1
chr3_106514922_106515103	0.23	Dennd2d	DENN/MADD domain containing 2D	21837	0.11
chr6_121878379_121878709	0.23	Mug1	murinoglobulin 1	7033	0.2
chr8_68062613_68062915	0.23	Psd3	pleckstrin and Sec7 domain containing 3	478	0.86
chr4_138262391_138262595	0.23	Kif17	kinesin family member 17	6	0.96
chr9_120933701_120933852	0.23	Ctnnb1	catenin (cadherin associated protein), beta 1	42	0.95
chr17_7443940_7444098	0.22	Gm6553	predicted gene 6553	13777	0.19
chr13_55321508_55321662	0.22	Rab24	RAB24, member RAS oncogene family	194	0.71
chr7_130577474_130577931	0.22	Tacc2	transforming, acidic coiled-coil containing protein 2	218	0.92
chr15_83563229_83563380	0.22	Tspo	translocator protein	288	0.63
chr1_45627972_45628123	0.22	Gm8304	predicted gene 8304	26021	0.17
chr11_95397945_95398308	0.22	Slc35b1	solute carrier family 35, member B1	8141	0.13
chr5_118004722_118004887	0.22	Gm42545	predicted gene 42545	22566	0.12
chr15_87045730_87045890	0.22	Gm23416	predicted gene, 23416	23183	0.18
chr4_122455220_122455373	0.22	Gm12895	predicted gene 12895	86	0.98
chr2_132869809_132870198	0.22	Lrrn4	leucine rich repeat neuronal 4	10888	0.13
chr17_28274865_28275039	0.21	Ppard	peroxisome proliferator activator receptor delta	2833	0.16
chr15_78178475_78178665	0.21	Gm49694	predicted gene, 49694	4109	0.16
chr10_80611135_80611333	0.21	Scamp4	secretory carrier membrane protein 4	989	0.27
chr8_94942711_94942867	0.21	Adgrg5	adhesion G protein-coupled receptor G5	8622	0.12
chr4_135508053_135508210	0.21	Gm25317	predicted gene, 25317	4348	0.14
chr10_75160623_75160782	0.21	Bcr	BCR activator of RhoGEF and GTPase	342	0.9
chr12_26415244_26415422	0.21	Rnf144a	ring finger protein 144A	79	0.79
chr9_21161475_21161850	0.21	Pde4a	phosphodiesterase 4A, cAMP specific	4052	0.12
chr16_4268162_4268330	0.21	Gm5766	predicted gene 5766	37945	0.13
chr8_122660121_122660272	0.21	Cbfa2t3	CBFA2/RUNX1 translocation partner 3	13730	0.09
chr10_60005449_60005609	0.21	Ascc1	activating signal cointegrator 1 complex subunit 1	2202	0.26
chr10_97249598_97249782	0.21	Gm18515	predicted gene, 18515	7778	0.26
chr4_122122855_122123016	0.21	Gm12896	predicted gene 12896	88	0.98
chr2_109693213_109693439	0.21	Bdnf	brain derived neurotrophic factor	237	0.93
chr17_31637083_31637756	0.21	Cbs	cystathionine beta-synthase	181	0.89
chr7_129649085_129649245	0.21	Gm39094	predicted gene, 39094	9763	0.2
chr11_69340671_69341048	0.21	Rnf227	ring finger protein 227	50	0.93
chr9_123665785_123665936	0.21	Gm17200	predicted gene 17200	12236	0.09
chr18_46713280_46713447	0.20	Cdo1	cysteine dioxygenase 1, cytosolic	14666	0.13
chr18_35662151_35662309	0.20	Spata24	spermatogenesis associated 24	44	0.51
chr11_74638791_74638959	0.20	Cluh	clustered mitochondria (cluA/CLU1) homolog	10620	0.15
chr12_102623965_102624273	0.20	Gm20069	predicted gene, 20069	11439	0.13
chr13_60479839_60480430	0.20	Gm48500	predicted gene, 48500	1164	0.45
chr6_42325328_42325493	0.20	Fam131b	family with sequence similarity 131, member B	767	0.44
chr14_22019673_22019870	0.20	Lrmda	leucine rich melanocyte differentiation associated	50	0.96
chr1_92647884_92648048	0.20	Otos	otospiralin	288	0.83
chr2_152081883_152082034	0.20	Scrt2	scratch family zinc finger 2	429	0.78
chr9_103258204_103258373	0.20	1300017J02Rik	RIKEN cDNA 1300017J02 gene	1262	0.42
chr5_125271875_125272026	0.20	Gm32585	predicted gene, 32585	865	0.57
chr17_31390196_31390347	0.20	Pde9a	phosphodiesterase 9A	3977	0.17
chr14_20794215_20794517	0.20	Gm30108	predicted gene, 30108	127	0.69
chr19_28975451_28975625	0.20	Gm3621	predicted gene 3621	2499	0.17
chr6_128736252_128736414	0.20	Gm43907	predicted gene, 43907	8311	0.11
chr1_180991444_180991626	0.20	Ephx1	epoxide hydrolase 1, microsomal	4635	0.11
chrX_101419042_101419230	0.20	Zmym3	zinc finger, MYM-type 3	662	0.61
chr15_102126408_102126761	0.20	Spryd3	SPRY domain containing 3	2300	0.17
chr11_50431056_50431230	0.20	Rufy1	RUN and FYVE domain containing 1	18	0.98
chr10_70599538_70599732	0.19	Phyhipl	phytanoyl-CoA hydroxylase interacting protein-like	344	0.91
chr4_116008423_116008814	0.19	Faah	fatty acid amide hydrolase	8550	0.14
chr13_7428915_7429066	0.19	Gm36074	predicted gene, 36074	17519	0.27
chr17_56935189_56935340	0.19	Mllt1	myeloid/lymphoid or mixed-lineage leukemia; translocated to, 1	151	0.92
chr9_30124659_30124991	0.19	Gm47677	predicted gene, 47677	42750	0.18
chr10_125949154_125949327	0.19	Lrig3	leucine-rich repeats and immunoglobulin-like domains 3	16928	0.28
chr9_35139662_35139830	0.19	Gm24262	predicted gene, 24262	4890	0.14
chr12_113859003_113859160	0.19	Ighv5-18	immunoglobulin heavy variable V5-18	17158	0.11
chr16_85173682_85173850	0.19	App	amyloid beta (A4) precursor protein	0	0.98
chr6_147042911_147043077	0.19	Mrps35	mitochondrial ribosomal protein S35	230	0.89
chr15_76369272_76369423	0.19	Hgh1	HGH1 homolog	134	0.88
chr2_179290486_179290655	0.19	Gm14293	predicted gene 14293	50080	0.15
chr16_20537030_20537361	0.19	Ap2m1	adaptor-related protein complex 2, mu 1 subunit	417	0.62
chr1_74338040_74338254	0.19	Pnkd	paroxysmal nonkinesiogenic dyskinesia	5484	0.1
chr15_81849441_81849616	0.19	Gm8444	predicted gene 8444	5815	0.1
chr11_94732887_94733059	0.19	Cdc34b	cell division cycle 34B	8809	0.11
chr11_102753302_102753453	0.19	Adam11	a disintegrin and metallopeptidase domain 11	8062	0.11
chr18_5085122_5085283	0.19	Svil	supervillin	9179	0.28
chr3_89436568_89436763	0.19	Pbxip1	pre B cell leukemia transcription factor interacting protein 1	41	0.94
chr8_20557902_20558131	0.19	Gm21182	predicted gene, 21182	530	0.76
chr3_107631354_107631565	0.19	Gm10961	predicted gene 10961	137	0.63
chr5_66618891_66619162	0.18	Apbb2	amyloid beta (A4) precursor protein-binding, family B, member 2	242	0.91
chr15_36609144_36609341	0.18	Pabpc1	poly(A) binding protein, cytoplasmic 1	269	0.88
chr2_164952558_164952709	0.18	Mmp9	matrix metallopeptidase 9	1753	0.24
chr15_83724999_83725153	0.18	Scube1	signal peptide, CUB domain, EGF-like 1	55	0.98
chr1_181475618_181475786	0.18	Ccdc121	coiled-coil domain containing 121	35749	0.14
chr5_121546456_121546786	0.18	Mapkapk5	MAP kinase-activated protein kinase 5	716	0.35
chr18_34373553_34373724	0.18	Reep5	receptor accessory protein 5	269	0.91

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of Zic4

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.4	GO:0045218	zonula adherens maintenance(GO:0045218)
0.1	0.4	GO:0070428	regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070428)
0.1	0.3	GO:1903286	regulation of potassium ion import(GO:1903286) positive regulation of potassium ion import(GO:1903288)
0.1	1.6	GO:2000310	regulation of N-methyl-D-aspartate selective glutamate receptor activity(GO:2000310)
0.1	0.3	GO:0006546	glycine catabolic process(GO:0006546) glycine decarboxylation via glycine cleavage system(GO:0019464)
0.1	0.3	GO:0061043	regulation of vascular wound healing(GO:0061043)
0.1	0.3	GO:1902630	regulation of membrane hyperpolarization(GO:1902630)
0.1	0.1	GO:1903275	positive regulation of sodium ion export(GO:1903275) positive regulation of sodium ion export from cell(GO:1903278)
0.1	0.2	GO:0019344	cysteine biosynthetic process(GO:0019344)
0.1	0.2	GO:0007403	glial cell fate determination(GO:0007403)
0.1	0.2	GO:0010751	negative regulation of nitric oxide mediated signal transduction(GO:0010751)
0.1	0.2	GO:0007228	positive regulation of hh target transcription factor activity(GO:0007228)
0.1	0.3	GO:0032482	Rab protein signal transduction(GO:0032482)
0.1	0.2	GO:0071873	response to norepinephrine(GO:0071873)
0.1	0.1	GO:0035887	aortic smooth muscle cell differentiation(GO:0035887)
0.1	0.2	GO:1902564	negative regulation of neutrophil activation(GO:1902564)
0.1	0.2	GO:0090210	regulation of establishment of blood-brain barrier(GO:0090210)
0.1	0.2	GO:0061091	regulation of phospholipid translocation(GO:0061091) positive regulation of phospholipid translocation(GO:0061092)
0.1	0.7	GO:0000083	regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0000083)
0.1	0.2	GO:0035359	negative regulation of peroxisome proliferator activated receptor signaling pathway(GO:0035359)
0.1	0.2	GO:0042891	antibiotic transport(GO:0042891)
0.1	0.3	GO:0048840	otolith development(GO:0048840)
0.1	0.8	GO:0032012	ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.0	0.2	GO:0007412	axon target recognition(GO:0007412)
0.0	0.1	GO:0006393	termination of mitochondrial transcription(GO:0006393)
0.0	0.2	GO:2000370	positive regulation of clathrin-mediated endocytosis(GO:2000370)
0.0	0.1	GO:0010481	epidermal cell division(GO:0010481) regulation of epidermal cell division(GO:0010482)
0.0	0.0	GO:1903753	negative regulation of p38MAPK cascade(GO:1903753)
0.0	0.2	GO:0090666	scaRNA localization to Cajal body(GO:0090666)
0.0	0.2	GO:0070885	negative regulation of calcineurin-NFAT signaling cascade(GO:0070885)
0.0	0.1	GO:0048549	positive regulation of pinocytosis(GO:0048549)
0.0	0.1	GO:0042851	L-alanine metabolic process(GO:0042851)
0.0	0.2	GO:2000049	positive regulation of cell-cell adhesion mediated by cadherin(GO:2000049)
0.0	0.2	GO:0072383	plus-end-directed vesicle transport along microtubule(GO:0072383) plus-end-directed organelle transport along microtubule(GO:0072386)
0.0	0.1	GO:0002125	maternal aggressive behavior(GO:0002125)
0.0	0.3	GO:0099515	actin filament-based transport(GO:0099515)
0.0	0.3	GO:0021798	forebrain dorsal/ventral pattern formation(GO:0021798)
0.0	0.2	GO:2000623	regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000622) negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000623)
0.0	0.3	GO:0007207	adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway(GO:0007197) phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway(GO:0007207)
0.0	0.1	GO:0048207	vesicle targeting, rough ER to cis-Golgi(GO:0048207) COPII vesicle coating(GO:0048208)
0.0	0.1	GO:0035973	aggrephagy(GO:0035973)
0.0	0.2	GO:0018076	N-terminal peptidyl-lysine acetylation(GO:0018076)
0.0	0.1	GO:0035483	gastric emptying(GO:0035483)
0.0	0.1	GO:0070164	negative regulation of adiponectin secretion(GO:0070164)
0.0	0.1	GO:0019626	short-chain fatty acid catabolic process(GO:0019626)
0.0	0.1	GO:0034773	histone H4-K20 trimethylation(GO:0034773)
0.0	0.4	GO:0046831	regulation of RNA export from nucleus(GO:0046831)
0.0	0.1	GO:2000047	regulation of cell-cell adhesion mediated by cadherin(GO:2000047)
0.0	0.1	GO:0070889	platelet alpha granule organization(GO:0070889)
0.0	0.1	GO:2000741	positive regulation of mesenchymal stem cell differentiation(GO:2000741)
0.0	0.1	GO:0030208	dermatan sulfate biosynthetic process(GO:0030208)
0.0	0.0	GO:0097106	postsynaptic density organization(GO:0097106) postsynaptic density assembly(GO:0097107)
0.0	0.1	GO:0035021	negative regulation of Rac protein signal transduction(GO:0035021)
0.0	0.1	GO:0032439	endosome localization(GO:0032439)
0.0	0.1	GO:0016561	protein import into peroxisome matrix, translocation(GO:0016561)
0.0	0.2	GO:0072656	maintenance of protein location in mitochondrion(GO:0072656)
0.0	0.1	GO:1902915	negative regulation of protein K63-linked ubiquitination(GO:1900045) negative regulation of protein polyubiquitination(GO:1902915)
0.0	0.1	GO:0016095	polyprenol catabolic process(GO:0016095)
0.0	0.1	GO:0098902	regulation of membrane depolarization during action potential(GO:0098902)
0.0	0.1	GO:0097296	activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:0097296)
0.0	0.1	GO:0060431	primary lung bud formation(GO:0060431)
0.0	0.1	GO:0090309	positive regulation of methylation-dependent chromatin silencing(GO:0090309)
0.0	0.5	GO:0042572	retinol metabolic process(GO:0042572)
0.0	0.3	GO:0030953	astral microtubule organization(GO:0030953)
0.0	0.1	GO:0045715	negative regulation of low-density lipoprotein particle receptor biosynthetic process(GO:0045715)
0.0	0.1	GO:0046951	ketone body biosynthetic process(GO:0046951)
0.0	0.1	GO:0045896	regulation of transcription during mitosis(GO:0045896) positive regulation of transcription during mitosis(GO:0045897)
0.0	0.1	GO:1903599	positive regulation of mitophagy(GO:1903599)
0.0	0.1	GO:0048696	regulation of collateral sprouting in absence of injury(GO:0048696)
0.0	0.1	GO:1902071	regulation of hypoxia-inducible factor-1alpha signaling pathway(GO:1902071)
0.0	0.1	GO:2000664	positive regulation of interleukin-5 secretion(GO:2000664) positive regulation of interleukin-13 secretion(GO:2000667)
0.0	0.2	GO:0071578	zinc II ion transmembrane import(GO:0071578)
0.0	0.1	GO:0071442	positive regulation of histone H3-K14 acetylation(GO:0071442)
0.0	0.2	GO:0031274	positive regulation of pseudopodium assembly(GO:0031274)
0.0	0.1	GO:0034139	regulation of toll-like receptor 3 signaling pathway(GO:0034139)
0.0	0.1	GO:0019355	nicotinamide nucleotide biosynthetic process from aspartate(GO:0019355) 'de novo' NAD biosynthetic process from aspartate(GO:0034628)
0.0	0.1	GO:0015772	disaccharide transport(GO:0015766) sucrose transport(GO:0015770) oligosaccharide transport(GO:0015772)
0.0	0.1	GO:0030638	polyketide metabolic process(GO:0030638) aminoglycoside antibiotic metabolic process(GO:0030647) daunorubicin metabolic process(GO:0044597) doxorubicin metabolic process(GO:0044598)
0.0	0.1	GO:0051596	methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione(GO:0019243) methylglyoxal catabolic process(GO:0051596) methylglyoxal catabolic process to lactate(GO:0061727)
0.0	0.1	GO:1901420	negative regulation of response to alcohol(GO:1901420)
0.0	0.1	GO:1900122	positive regulation of receptor binding(GO:1900122)
0.0	0.0	GO:0090296	regulation of mitochondrial DNA replication(GO:0090296)
0.0	0.1	GO:0035589	G-protein coupled purinergic nucleotide receptor signaling pathway(GO:0035589)
0.0	0.1	GO:0060221	retinal rod cell differentiation(GO:0060221)
0.0	0.0	GO:0060066	oviduct development(GO:0060066)
0.0	0.1	GO:0061113	pancreas morphogenesis(GO:0061113)
0.0	0.1	GO:0071462	cellular response to water stimulus(GO:0071462)
0.0	0.1	GO:0061511	centriole elongation(GO:0061511)
0.0	0.1	GO:2000562	negative regulation of CD4-positive, alpha-beta T cell proliferation(GO:2000562)
0.0	0.1	GO:1903715	regulation of aerobic respiration(GO:1903715)
0.0	0.1	GO:1904059	regulation of locomotor rhythm(GO:1904059)
0.0	0.1	GO:0006561	proline biosynthetic process(GO:0006561)
0.0	0.1	GO:1900738	positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathway(GO:1900738)
0.0	0.0	GO:0006501	C-terminal protein lipidation(GO:0006501)
0.0	0.1	GO:0046959	habituation(GO:0046959)
0.0	0.0	GO:2000698	positive regulation of epithelial cell differentiation involved in kidney development(GO:2000698)
0.0	0.0	GO:0014858	positive regulation of skeletal muscle cell proliferation(GO:0014858)
0.0	0.1	GO:0009182	purine deoxyribonucleoside diphosphate metabolic process(GO:0009182) dGDP metabolic process(GO:0046066)
0.0	0.1	GO:0046271	phenylpropanoid catabolic process(GO:0046271)
0.0	0.0	GO:1901187	regulation of ephrin receptor signaling pathway(GO:1901187)
0.0	0.0	GO:2000974	negative regulation of pro-B cell differentiation(GO:2000974)
0.0	0.0	GO:0044857	plasma membrane raft assembly(GO:0044854) plasma membrane raft organization(GO:0044857)
0.0	0.1	GO:0097118	neuroligin clustering involved in postsynaptic membrane assembly(GO:0097118)
0.0	0.1	GO:0035511	oxidative DNA demethylation(GO:0035511)
0.0	0.1	GO:0032876	negative regulation of DNA endoreduplication(GO:0032876)
0.0	0.0	GO:0097460	ferrous iron import into cell(GO:0097460)
0.0	0.1	GO:0061144	alveolar secondary septum development(GO:0061144)
0.0	0.1	GO:0060528	secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development(GO:0060528)
0.0	0.1	GO:0090400	stress-induced premature senescence(GO:0090400)
0.0	0.1	GO:0060161	positive regulation of dopamine receptor signaling pathway(GO:0060161)
0.0	0.0	GO:0045404	interleukin-4 biosynthetic process(GO:0042097) regulation of interleukin-4 biosynthetic process(GO:0045402) positive regulation of interleukin-4 biosynthetic process(GO:0045404)
0.0	0.0	GO:1902566	regulation of eosinophil degranulation(GO:0043309) regulation of eosinophil activation(GO:1902566)
0.0	0.1	GO:0006189	'de novo' IMP biosynthetic process(GO:0006189)
0.0	0.1	GO:0070779	D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
0.0	0.1	GO:0006597	spermine biosynthetic process(GO:0006597)
0.0	0.0	GO:0036151	phosphatidylcholine acyl-chain remodeling(GO:0036151)
0.0	0.1	GO:2001199	negative regulation of dendritic cell differentiation(GO:2001199)
0.0	0.0	GO:0019448	cysteine catabolic process(GO:0009093) L-cysteine catabolic process(GO:0019448) L-cysteine metabolic process(GO:0046439)
0.0	0.1	GO:0046469	platelet activating factor biosynthetic process(GO:0006663) platelet activating factor metabolic process(GO:0046469)
0.0	0.0	GO:1900739	regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900739) positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900740)
0.0	0.0	GO:0044339	canonical Wnt signaling pathway involved in osteoblast differentiation(GO:0044339)
0.0	0.1	GO:2000189	positive regulation of cholesterol homeostasis(GO:2000189)
0.0	0.1	GO:1902231	positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage(GO:1902231)
0.0	0.2	GO:0006516	glycoprotein catabolic process(GO:0006516)
0.0	0.0	GO:0022009	central nervous system vasculogenesis(GO:0022009)
0.0	0.0	GO:0044333	Wnt signaling pathway involved in digestive tract morphogenesis(GO:0044333)
0.0	0.1	GO:0000244	spliceosomal tri-snRNP complex assembly(GO:0000244)
0.0	0.1	GO:0007066	female meiosis sister chromatid cohesion(GO:0007066)
0.0	0.0	GO:0070368	positive regulation of hepatocyte differentiation(GO:0070368)
0.0	0.0	GO:1904526	regulation of microtubule binding(GO:1904526) positive regulation of microtubule binding(GO:1904528)
0.0	0.0	GO:0000414	regulation of histone H3-K36 methylation(GO:0000414)
0.0	0.1	GO:0060633	negative regulation of transcription initiation from RNA polymerase II promoter(GO:0060633) negative regulation of DNA-templated transcription, initiation(GO:2000143)
0.0	0.2	GO:0051444	negative regulation of ubiquitin-protein transferase activity(GO:0051444)
0.0	0.1	GO:2000394	positive regulation of lamellipodium morphogenesis(GO:2000394)
0.0	0.1	GO:0046726	positive regulation by virus of viral protein levels in host cell(GO:0046726)
0.0	0.1	GO:0048170	positive regulation of long-term neuronal synaptic plasticity(GO:0048170)
0.0	0.0	GO:0033159	negative regulation of protein import into nucleus, translocation(GO:0033159)
0.0	0.1	GO:0032754	positive regulation of interleukin-5 production(GO:0032754)
0.0	0.0	GO:2001274	negative regulation of glucose import in response to insulin stimulus(GO:2001274)
0.0	0.1	GO:0051121	hepoxilin metabolic process(GO:0051121) hepoxilin biosynthetic process(GO:0051122)
0.0	0.1	GO:0051697	protein delipidation(GO:0051697)
0.0	0.0	GO:0035609	C-terminal protein deglutamylation(GO:0035609)
0.0	0.0	GO:0021699	cerebellar cortex maturation(GO:0021699)
0.0	0.1	GO:0045053	protein retention in Golgi apparatus(GO:0045053)
0.0	0.1	GO:0030174	regulation of DNA-dependent DNA replication initiation(GO:0030174)
0.0	0.3	GO:0048488	synaptic vesicle endocytosis(GO:0048488)
0.0	0.1	GO:0061179	negative regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0061179)
0.0	0.1	GO:1902459	positive regulation of stem cell population maintenance(GO:1902459)
0.0	0.0	GO:0072201	negative regulation of mesenchymal cell proliferation(GO:0072201)
0.0	0.1	GO:0016255	attachment of GPI anchor to protein(GO:0016255)
0.0	0.3	GO:0071108	protein K48-linked deubiquitination(GO:0071108)
0.0	0.1	GO:0010724	regulation of definitive erythrocyte differentiation(GO:0010724)
0.0	0.1	GO:0036233	glycine import(GO:0036233)
0.0	0.2	GO:2000311	regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000311)
0.0	0.1	GO:0017196	N-terminal peptidyl-methionine acetylation(GO:0017196)
0.0	0.2	GO:0046548	retinal rod cell development(GO:0046548)
0.0	0.1	GO:1903025	regulation of RNA polymerase II regulatory region sequence-specific DNA binding(GO:1903025)
0.0	0.0	GO:1902498	regulation of protein autoubiquitination(GO:1902498)
0.0	0.0	GO:0090241	negative regulation of histone H4 acetylation(GO:0090241)
0.0	0.1	GO:0048194	Golgi vesicle budding(GO:0048194)
0.0	0.0	GO:0070340	detection of bacterial lipopeptide(GO:0070340)
0.0	0.1	GO:0090166	Golgi disassembly(GO:0090166)
0.0	0.1	GO:0035745	T-helper 2 cell cytokine production(GO:0035745)
0.0	0.0	GO:1903279	regulation of calcium:sodium antiporter activity(GO:1903279)
0.0	0.1	GO:0008655	pyrimidine-containing compound salvage(GO:0008655) pyrimidine nucleoside salvage(GO:0043097)
0.0	0.1	GO:0090308	regulation of methylation-dependent chromatin silencing(GO:0090308)
0.0	0.0	GO:2000507	positive regulation of energy homeostasis(GO:2000507)
0.0	0.1	GO:0090148	membrane fission(GO:0090148)
0.0	0.1	GO:2001140	regulation of phospholipid transport(GO:2001138) positive regulation of phospholipid transport(GO:2001140)
0.0	0.1	GO:1902894	negative regulation of pri-miRNA transcription from RNA polymerase II promoter(GO:1902894)
0.0	0.0	GO:0014053	negative regulation of gamma-aminobutyric acid secretion(GO:0014053)
0.0	0.0	GO:0070973	protein localization to endoplasmic reticulum exit site(GO:0070973)
0.0	0.1	GO:0033762	response to glucagon(GO:0033762)
0.0	0.0	GO:0002017	regulation of blood volume by renal aldosterone(GO:0002017)
0.0	0.1	GO:0015867	ATP transport(GO:0015867)
0.0	0.1	GO:2000188	regulation of cholesterol homeostasis(GO:2000188)
0.0	0.0	GO:0010956	negative regulation of calcidiol 1-monooxygenase activity(GO:0010956)
0.0	0.0	GO:0009449	gamma-aminobutyric acid biosynthetic process(GO:0009449)
0.0	0.0	GO:0021914	negative regulation of smoothened signaling pathway involved in ventral spinal cord patterning(GO:0021914)
0.0	0.1	GO:0060033	anatomical structure regression(GO:0060033)
0.0	0.0	GO:0035694	mitochondrial protein catabolic process(GO:0035694)
0.0	0.1	GO:0010991	negative regulation of SMAD protein complex assembly(GO:0010991)
0.0	0.0	GO:0033353	S-adenosylmethionine cycle(GO:0033353)
0.0	0.0	GO:0001828	inner cell mass cellular morphogenesis(GO:0001828)
0.0	0.0	GO:0006562	proline catabolic process(GO:0006562)
0.0	0.0	GO:0030091	protein repair(GO:0030091)
0.0	0.0	GO:0016554	cytidine to uridine editing(GO:0016554)
0.0	0.0	GO:2001166	regulation of histone H2B ubiquitination(GO:2001166) positive regulation of histone H2B ubiquitination(GO:2001168)
0.0	0.0	GO:1900194	negative regulation of oocyte maturation(GO:1900194)
0.0	0.0	GO:0035513	oxidative RNA demethylation(GO:0035513) oxidative single-stranded RNA demethylation(GO:0035553)
0.0	0.1	GO:1901897	regulation of relaxation of cardiac muscle(GO:1901897)
0.0	0.0	GO:0060375	mast cell differentiation(GO:0060374) regulation of mast cell differentiation(GO:0060375)
0.0	0.0	GO:0034770	histone H4-K20 methylation(GO:0034770)
0.0	0.0	GO:0048003	antigen processing and presentation of lipid antigen via MHC class Ib(GO:0048003) antigen processing and presentation, exogenous lipid antigen via MHC class Ib(GO:0048007)
0.0	0.2	GO:0033539	fatty acid beta-oxidation using acyl-CoA dehydrogenase(GO:0033539)
0.0	0.0	GO:1901679	pyrimidine-containing compound transmembrane transport(GO:0072531) nucleotide transmembrane transport(GO:1901679)
0.0	0.0	GO:1903377	negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903377)
0.0	0.1	GO:0006670	sphingosine metabolic process(GO:0006670)
0.0	0.1	GO:0030432	peristalsis(GO:0030432)
0.0	0.0	GO:0009436	glyoxylate catabolic process(GO:0009436)
0.0	0.0	GO:0045039	protein import into mitochondrial inner membrane(GO:0045039)
0.0	0.1	GO:0000056	ribosomal small subunit export from nucleus(GO:0000056)
0.0	0.0	GO:1903237	negative regulation of leukocyte tethering or rolling(GO:1903237)
0.0	0.0	GO:1903626	positive regulation of apoptotic DNA fragmentation(GO:1902512) positive regulation of DNA catabolic process(GO:1903626)
0.0	0.1	GO:0010961	cellular magnesium ion homeostasis(GO:0010961)
0.0	0.0	GO:0033092	positive regulation of immature T cell proliferation in thymus(GO:0033092)
0.0	0.1	GO:0060088	auditory receptor cell stereocilium organization(GO:0060088)
0.0	0.0	GO:0086043	bundle of His cell to Purkinje myocyte signaling(GO:0086028) bundle of His cell action potential(GO:0086043)
0.0	0.1	GO:0030643	cellular phosphate ion homeostasis(GO:0030643) cellular trivalent inorganic anion homeostasis(GO:0072502)
0.0	0.1	GO:0006104	succinyl-CoA metabolic process(GO:0006104)
0.0	0.0	GO:0008626	granzyme-mediated apoptotic signaling pathway(GO:0008626)
0.0	0.1	GO:0048227	plasma membrane to endosome transport(GO:0048227)
0.0	0.1	GO:0030206	chondroitin sulfate biosynthetic process(GO:0030206)
0.0	0.0	GO:0035526	retrograde transport, plasma membrane to Golgi(GO:0035526)
0.0	0.2	GO:0035066	positive regulation of histone acetylation(GO:0035066)
0.0	0.1	GO:0051451	myoblast migration(GO:0051451)
0.0	0.1	GO:0035855	megakaryocyte development(GO:0035855)
0.0	0.0	GO:1902075	cellular response to salt(GO:1902075)
0.0	0.0	GO:0002019	regulation of renal output by angiotensin(GO:0002019)
0.0	0.0	GO:0031117	positive regulation of microtubule depolymerization(GO:0031117)
0.0	0.0	GO:0043622	cortical microtubule organization(GO:0043622)
0.0	0.2	GO:0043011	myeloid dendritic cell differentiation(GO:0043011)
0.0	0.4	GO:0071277	cellular response to calcium ion(GO:0071277)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:0005642	annulate lamellae(GO:0005642)
0.1	0.2	GO:0034750	Scrib-APC-beta-catenin complex(GO:0034750)
0.1	0.4	GO:0005915	zonula adherens(GO:0005915)
0.1	0.2	GO:1990761	growth cone lamellipodium(GO:1990761)
0.1	0.2	GO:0097149	centralspindlin complex(GO:0097149)
0.1	0.7	GO:0005640	nuclear outer membrane(GO:0005640)
0.0	0.3	GO:0005890	sodium:potassium-exchanging ATPase complex(GO:0005890)
0.0	0.3	GO:0030991	intraciliary transport particle A(GO:0030991)
0.0	0.1	GO:0002139	stereocilia coupling link(GO:0002139)
0.0	0.1	GO:0017133	mitochondrial electron transfer flavoprotein complex(GO:0017133) electron transfer flavoprotein complex(GO:0045251)
0.0	0.3	GO:0031462	Cul2-RING ubiquitin ligase complex(GO:0031462)
0.0	0.2	GO:0044294	dendritic growth cone(GO:0044294)
0.0	0.1	GO:0044326	dendritic spine neck(GO:0044326)
0.0	0.1	GO:0016222	procollagen-proline 4-dioxygenase complex(GO:0016222)
0.0	0.2	GO:0016600	flotillin complex(GO:0016600)
0.0	0.1	GO:0042406	extrinsic component of endoplasmic reticulum membrane(GO:0042406)
0.0	0.2	GO:0005577	fibrinogen complex(GO:0005577)
0.0	0.1	GO:0031258	lamellipodium membrane(GO:0031258)
0.0	0.2	GO:0005832	chaperonin-containing T-complex(GO:0005832)
0.0	0.1	GO:0016342	catenin complex(GO:0016342)
0.0	0.1	GO:0042583	chromaffin granule(GO:0042583)
0.0	0.1	GO:1990075	periciliary membrane compartment(GO:1990075)
0.0	0.2	GO:0046581	intercellular canaliculus(GO:0046581)
0.0	0.1	GO:0033256	I-kappaB/NF-kappaB complex(GO:0033256)
0.0	0.1	GO:0005785	signal recognition particle receptor complex(GO:0005785)
0.0	0.1	GO:0034363	intermediate-density lipoprotein particle(GO:0034363)
0.0	0.2	GO:0030061	mitochondrial crista(GO:0030061)
0.0	0.1	GO:0071986	Ragulator complex(GO:0071986)
0.0	0.1	GO:0000235	astral microtubule(GO:0000235)
0.0	0.2	GO:1990124	messenger ribonucleoprotein complex(GO:1990124)
0.0	0.1	GO:0000120	RNA polymerase I transcription factor complex(GO:0000120)
0.0	0.1	GO:0000124	SAGA complex(GO:0000124)
0.0	0.2	GO:0000940	condensed chromosome outer kinetochore(GO:0000940)
0.0	0.3	GO:0097440	apical dendrite(GO:0097440)
0.0	0.2	GO:0032279	asymmetric synapse(GO:0032279)
0.0	0.0	GO:0097454	Schwann cell microvillus(GO:0097454)
0.0	0.1	GO:0016281	eukaryotic translation initiation factor 4F complex(GO:0016281)
0.0	0.1	GO:0042765	GPI-anchor transamidase complex(GO:0042765)
0.0	0.0	GO:0042719	mitochondrial intermembrane space protein transporter complex(GO:0042719)
0.0	0.1	GO:0031232	extrinsic component of external side of plasma membrane(GO:0031232)
0.0	0.1	GO:0031415	NatA complex(GO:0031415)
0.0	0.0	GO:0000802	transverse filament(GO:0000802)
0.0	0.0	GO:0000835	ER ubiquitin ligase complex(GO:0000835) Hrd1p ubiquitin ligase complex(GO:0000836)
0.0	0.1	GO:0030062	mitochondrial tricarboxylic acid cycle enzyme complex(GO:0030062)
0.0	0.0	GO:0009279	cell outer membrane(GO:0009279) cell envelope(GO:0030313) external encapsulating structure part(GO:0044462)
0.0	0.0	GO:0005594	collagen type IX trimer(GO:0005594)
0.0	0.1	GO:0005827	polar microtubule(GO:0005827)
0.0	0.1	GO:0008278	cohesin complex(GO:0008278)
0.0	0.0	GO:0030015	CCR4-NOT core complex(GO:0030015)
0.0	0.2	GO:0005779	integral component of peroxisomal membrane(GO:0005779)
0.0	0.0	GO:0038037	G-protein coupled receptor dimeric complex(GO:0038037) G-protein coupled receptor complex(GO:0097648)
0.0	0.1	GO:0070775	H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776)
0.0	0.1	GO:0035749	myelin sheath adaxonal region(GO:0035749)
0.0	0.5	GO:0019005	SCF ubiquitin ligase complex(GO:0019005)
0.0	0.1	GO:0000815	ESCRT III complex(GO:0000815)
0.0	0.0	GO:0016942	insulin-like growth factor binding protein complex(GO:0016942) growth factor complex(GO:0036454) insulin-like growth factor ternary complex(GO:0042567)
0.0	0.0	GO:0090533	cation-transporting ATPase complex(GO:0090533)
0.0	0.1	GO:0014731	spectrin-associated cytoskeleton(GO:0014731)
0.0	0.0	GO:0000938	GARP complex(GO:0000938)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:0017153	sodium:dicarboxylate symporter activity(GO:0017153)
0.1	0.3	GO:0030899	calcium-dependent ATPase activity(GO:0030899)
0.1	0.2	GO:1990188	euchromatin binding(GO:1990188)
0.1	1.5	GO:0017075	syntaxin-1 binding(GO:0017075)
0.1	0.2	GO:0042895	antibiotic transporter activity(GO:0042895)
0.1	0.1	GO:0008427	calcium-dependent protein kinase inhibitor activity(GO:0008427)
0.1	0.2	GO:0008525	phosphatidylcholine transporter activity(GO:0008525)
0.1	0.2	GO:0046573	lactonohydrolase activity(GO:0046573) acyl-L-homoserine-lactone lactonohydrolase activity(GO:0102007)
0.1	0.2	GO:0008503	benzodiazepine receptor activity(GO:0008503)
0.0	0.3	GO:0043495	protein anchor(GO:0043495)
0.0	0.1	GO:0051765	inositol tetrakisphosphate kinase activity(GO:0051765)
0.0	0.2	GO:0051425	PTB domain binding(GO:0051425)
0.0	0.3	GO:0070097	delta-catenin binding(GO:0070097)
0.0	0.6	GO:0001671	ATPase activator activity(GO:0001671)
0.0	0.1	GO:0042392	sphingosine-1-phosphate phosphatase activity(GO:0042392)
0.0	0.1	GO:0004416	hydroxyacylglutathione hydrolase activity(GO:0004416)
0.0	0.2	GO:0070052	collagen V binding(GO:0070052)
0.0	0.9	GO:0005086	ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.0	0.3	GO:0016907	G-protein coupled acetylcholine receptor activity(GO:0016907)
0.0	0.2	GO:0001515	opioid peptide activity(GO:0001515)
0.0	0.1	GO:0016715	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen(GO:0016715)
0.0	0.2	GO:0035473	lipase binding(GO:0035473)
0.0	0.1	GO:0004735	pyrroline-5-carboxylate reductase activity(GO:0004735)
0.0	0.1	GO:0031686	A1 adenosine receptor binding(GO:0031686)
0.0	0.2	GO:0022820	potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820)
0.0	0.1	GO:0047751	3-oxo-5-alpha-steroid 4-dehydrogenase activity(GO:0003865) cholestenone 5-alpha-reductase activity(GO:0047751)
0.0	0.1	GO:0004345	glucose-6-phosphate dehydrogenase activity(GO:0004345)
0.0	0.1	GO:1990430	extracellular matrix protein binding(GO:1990430)
0.0	0.1	GO:0031893	vasopressin receptor binding(GO:0031893)
0.0	0.1	GO:0004515	nicotinamide-nucleotide adenylyltransferase activity(GO:0000309) nicotinate-nucleotide adenylyltransferase activity(GO:0004515)
0.0	0.2	GO:0005113	patched binding(GO:0005113)
0.0	0.1	GO:0008515	sucrose:proton symporter activity(GO:0008506) sucrose transmembrane transporter activity(GO:0008515) disaccharide transmembrane transporter activity(GO:0015154) oligosaccharide transmembrane transporter activity(GO:0015157)
0.0	0.1	GO:0015093	ferrous iron transmembrane transporter activity(GO:0015093)
0.0	0.2	GO:0043008	ATP-dependent protein binding(GO:0043008)
0.0	0.1	GO:0070137	ubiquitin-like protein-specific endopeptidase activity(GO:0070137) SUMO-specific endopeptidase activity(GO:0070139)
0.0	0.1	GO:0031685	adenosine receptor binding(GO:0031685)
0.0	0.1	GO:0004886	9-cis retinoic acid receptor activity(GO:0004886)
0.0	0.3	GO:0016662	oxidoreductase activity, acting on other nitrogenous compounds as donors, cytochrome as acceptor(GO:0016662)
0.0	0.1	GO:0031750	D3 dopamine receptor binding(GO:0031750)
0.0	0.1	GO:0051959	dynein light intermediate chain binding(GO:0051959)
0.0	0.6	GO:0001540	beta-amyloid binding(GO:0001540)
0.0	0.1	GO:0030368	interleukin-17 receptor activity(GO:0030368)
0.0	0.1	GO:0102344	3-hydroxy-behenoyl-CoA dehydratase activity(GO:0102344) 3-hydroxy-lignoceroyl-CoA dehydratase activity(GO:0102345)
0.0	0.1	GO:0004301	epoxide hydrolase activity(GO:0004301)
0.0	0.1	GO:0005347	ATP transmembrane transporter activity(GO:0005347)
0.0	0.1	GO:0004656	procollagen-proline 4-dioxygenase activity(GO:0004656)
0.0	0.2	GO:0034450	ubiquitin-ubiquitin ligase activity(GO:0034450)
0.0	0.1	GO:0016721	superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721)
0.0	0.1	GO:0035514	DNA demethylase activity(GO:0035514)
0.0	0.1	GO:2001070	starch binding(GO:2001070)
0.0	0.1	GO:0052650	NADP-retinol dehydrogenase activity(GO:0052650)
0.0	0.1	GO:0051377	mannose-ethanolamine phosphotransferase activity(GO:0051377)
0.0	0.3	GO:0016594	glycine binding(GO:0016594)
0.0	0.2	GO:0004438	phosphatidylinositol-3-phosphatase activity(GO:0004438)
0.0	0.1	GO:1901612	cardiolipin binding(GO:1901612)
0.0	0.1	GO:0017169	CDP-alcohol phosphatidyltransferase activity(GO:0017169)
0.0	0.1	GO:0019788	NEDD8 transferase activity(GO:0019788)
0.0	0.1	GO:0003986	acetyl-CoA hydrolase activity(GO:0003986)
0.0	0.3	GO:0008143	poly(A) binding(GO:0008143)
0.0	0.2	GO:1990939	ATP-dependent microtubule motor activity(GO:1990939)
0.0	0.1	GO:0030229	very-low-density lipoprotein particle receptor activity(GO:0030229)
0.0	0.1	GO:0052851	cupric reductase activity(GO:0008823) ferric-chelate reductase (NADPH) activity(GO:0052851)
0.0	0.0	GO:0016802	adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.0	0.1	GO:0004994	somatostatin receptor activity(GO:0004994)
0.0	0.0	GO:1990050	phosphatidic acid transporter activity(GO:1990050)
0.0	0.1	GO:0015375	glycine:sodium symporter activity(GO:0015375)
0.0	0.1	GO:0098599	palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.0	1.2	GO:0004197	cysteine-type endopeptidase activity(GO:0004197)
0.0	0.1	GO:0016857	racemase and epimerase activity, acting on carbohydrates and derivatives(GO:0016857)
0.0	0.1	GO:0033592	RNA strand annealing activity(GO:0033592)
0.0	0.1	GO:0003997	acyl-CoA oxidase activity(GO:0003997)
0.0	0.1	GO:0005131	growth hormone receptor binding(GO:0005131)
0.0	0.2	GO:0044183	protein binding involved in protein folding(GO:0044183)
0.0	0.0	GO:0004719	protein-L-isoaspartate (D-aspartate) O-methyltransferase activity(GO:0004719)
0.0	0.0	GO:0015141	succinate transmembrane transporter activity(GO:0015141)
0.0	0.4	GO:0052677	C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity(GO:0000252) mevaldate reductase activity(GO:0004495) gluconate dehydrogenase activity(GO:0008875) epoxide dehydrogenase activity(GO:0018451) 5-exo-hydroxycamphor dehydrogenase activity(GO:0018452) 2-hydroxytetrahydrofuran dehydrogenase activity(GO:0018453) acetoin dehydrogenase activity(GO:0019152) phenylcoumaran benzylic ether reductase activity(GO:0032442) D-xylose:NADP reductase activity(GO:0032866) L-arabinose:NADP reductase activity(GO:0032867) D-arabinitol dehydrogenase, D-ribulose forming (NADP+) activity(GO:0033709) (R)-(-)-1,2,3,4-tetrahydronaphthol dehydrogenase activity(GO:0034831) 3-hydroxymenthone dehydrogenase activity(GO:0034840) very long-chain-3-hydroxyacyl-CoA dehydrogenase activity(GO:0035380) (R)-2-hydroxyisocaproate dehydrogenase activity(GO:0043713) L-arabinose 1-dehydrogenase (NADP+) activity(GO:0044103) L-xylulose reductase (NAD+) activity(GO:0044105) 3-ketoglucose-reductase activity(GO:0048258) D-arabinitol dehydrogenase, D-xylulose forming (NADP+) activity(GO:0052677)
0.0	0.1	GO:0031781	melanocortin receptor binding(GO:0031779) type 3 melanocortin receptor binding(GO:0031781) type 4 melanocortin receptor binding(GO:0031782)
0.0	0.1	GO:0046912	transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
0.0	0.4	GO:0019706	protein-cysteine S-palmitoyltransferase activity(GO:0019706)
0.0	0.1	GO:0070061	fructose binding(GO:0070061)
0.0	0.1	GO:0036033	mediator complex binding(GO:0036033)
0.0	0.0	GO:0030911	TPR domain binding(GO:0030911)
0.0	0.1	GO:0005222	intracellular cAMP activated cation channel activity(GO:0005222)
0.0	0.0	GO:0035650	AP-1 adaptor complex binding(GO:0035650)
0.0	0.1	GO:0005072	transforming growth factor beta receptor, cytoplasmic mediator activity(GO:0005072)
0.0	0.1	GO:0004908	interleukin-1 receptor activity(GO:0004908)
0.0	0.1	GO:0010314	phosphatidylinositol-5-phosphate binding(GO:0010314)
0.0	0.2	GO:0035497	cAMP response element binding(GO:0035497)
0.0	0.1	GO:0019808	polyamine binding(GO:0019808)
0.0	0.1	GO:0030898	actin-dependent ATPase activity(GO:0030898)
0.0	0.1	GO:0008568	microtubule-severing ATPase activity(GO:0008568)
0.0	0.1	GO:0030235	nitric-oxide synthase regulator activity(GO:0030235)
0.0	0.1	GO:0044020	histone methyltransferase activity (H4-R3 specific)(GO:0044020)
0.0	0.1	GO:0005068	transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
0.0	0.0	GO:0035663	Toll-like receptor 2 binding(GO:0035663)
0.0	0.2	GO:0043325	phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.0	0.1	GO:0005005	transmembrane-ephrin receptor activity(GO:0005005)
0.0	0.1	GO:0046975	histone methyltransferase activity (H3-K36 specific)(GO:0046975)
0.0	0.0	GO:0004687	myosin light chain kinase activity(GO:0004687)
0.0	0.1	GO:0001163	RNA polymerase I regulatory region sequence-specific DNA binding(GO:0001163) RNA polymerase I CORE element sequence-specific DNA binding(GO:0001164)
0.0	0.1	GO:0000182	rDNA binding(GO:0000182)
0.0	0.1	GO:0016176	superoxide-generating NADPH oxidase activator activity(GO:0016176)
0.0	0.0	GO:0035515	oxidative RNA demethylase activity(GO:0035515)
0.0	0.0	GO:0003941	L-serine ammonia-lyase activity(GO:0003941)
0.0	0.1	GO:0032027	myosin light chain binding(GO:0032027)
0.0	0.0	GO:0004965	G-protein coupled GABA receptor activity(GO:0004965)
0.0	0.1	GO:0004468	lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468)
0.0	0.0	GO:0072345	NAADP-sensitive calcium-release channel activity(GO:0072345)
0.0	0.0	GO:0008142	oxysterol binding(GO:0008142)
0.0	0.0	GO:0047045	testosterone 17-beta-dehydrogenase (NADP+) activity(GO:0047045)
0.0	0.0	GO:0004939	beta-adrenergic receptor activity(GO:0004939)
0.0	0.2	GO:0017049	GTP-Rho binding(GO:0017049)
0.0	0.0	GO:0016971	flavin-linked sulfhydryl oxidase activity(GO:0016971)
0.0	0.0	GO:0016018	cyclosporin A binding(GO:0016018)
0.0	0.1	GO:0045545	syndecan binding(GO:0045545)
0.0	0.1	GO:0051787	misfolded protein binding(GO:0051787)
0.0	0.0	GO:0004849	uridine kinase activity(GO:0004849)
0.0	0.0	GO:0004351	glutamate decarboxylase activity(GO:0004351)
0.0	0.0	GO:0008808	cardiolipin synthase activity(GO:0008808) phosphatidyltransferase activity(GO:0030572)

Gene overrepresentation in curated gene sets: canonical pathways category:

Total log-likelihood	Term	Description
0.1	SIG PIP3 SIGNALING IN B LYMPHOCYTES	Genes related to PIP3 signaling in B lymphocytes
1.8	PID IFNG PATHWAY	IFN-gamma pathway
0.3	PID VEGF VEGFR PATHWAY	VEGF and VEGFR signaling network
0.1	PID WNT CANONICAL PATHWAY	Canonical Wnt signaling pathway
0.5	PID ARF6 PATHWAY	Arf6 signaling events
0.3	PID SMAD2 3PATHWAY	Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.2	PID TCPTP PATHWAY	Signaling events mediated by TCPTP
0.1	PID S1P S1P3 PATHWAY	S1P3 pathway
0.3	PID GLYPICAN 1PATHWAY	Glypican 1 network
0.6	PID ECADHERIN STABILIZATION PATHWAY	Stabilization and expansion of the E-cadherin adherens junction
0.0	PID ERBB NETWORK PATHWAY	ErbB receptor signaling network
0.1	ST PAC1 RECEPTOR PATHWAY	PAC1 Receptor Pathway
0.1	PID ARF6 DOWNSTREAM PATHWAY	Arf6 downstream pathway
0.4	ST T CELL SIGNAL TRANSDUCTION	T Cell Signal Transduction
0.2	PID EPHB FWD PATHWAY	EPHB forward signaling
0.3	PID SHP2 PATHWAY	SHP2 signaling
0.0	ST PHOSPHOINOSITIDE 3 KINASE PATHWAY	PI3K Pathway
0.2	SA B CELL RECEPTOR COMPLEXES	Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	1.7	REACTOME ROLE OF DCC IN REGULATING APOPTOSIS	Genes involved in Role of DCC in regulating apoptosis
0.0	0.4	REACTOME IRAK1 RECRUITS IKK COMPLEX	Genes involved in IRAK1 recruits IKK complex
0.0	0.1	REACTOME RAP1 SIGNALLING	Genes involved in Rap1 signalling
0.0	0.3	REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS	Genes involved in Bile salt and organic anion SLC transporters
0.0	0.3	REACTOME VEGF LIGAND RECEPTOR INTERACTIONS	Genes involved in VEGF ligand-receptor interactions
0.0	0.3	REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS	Genes involved in Apoptotic cleavage of cell adhesion proteins
0.0	0.3	REACTOME RETROGRADE NEUROTROPHIN SIGNALLING	Genes involved in Retrograde neurotrophin signalling
0.0	0.2	REACTOME THE NLRP3 INFLAMMASOME	Genes involved in The NLRP3 inflammasome
0.0	0.1	REACTOME IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION	Genes involved in IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
0.0	0.3	REACTOME PLATELET CALCIUM HOMEOSTASIS	Genes involved in Platelet calcium homeostasis
0.0	0.3	REACTOME BASIGIN INTERACTIONS	Genes involved in Basigin interactions
0.0	0.2	REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE	Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.0	0.2	REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION	Genes involved in Amino acid synthesis and interconversion (transamination)
0.0	0.4	REACTOME NEP NS2 INTERACTS WITH THE CELLULAR EXPORT MACHINERY	Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery
0.0	0.0	REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE	Genes involved in mRNA Decay by 3' to 5' Exoribonuclease
0.0	0.3	REACTOME SULFUR AMINO ACID METABOLISM	Genes involved in Sulfur amino acid metabolism
0.0	0.3	REACTOME EFFECTS OF PIP2 HYDROLYSIS	Genes involved in Effects of PIP2 hydrolysis
0.0	0.0	REACTOME PI3K EVENTS IN ERBB2 SIGNALING	Genes involved in PI3K events in ERBB2 signaling
0.0	0.0	REACTOME PLATELET HOMEOSTASIS	Genes involved in Platelet homeostasis
0.0	0.1	REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24 HYDROXYCHOLESTEROL	Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol
0.0	0.0	REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE	Genes involved in Norepinephrine Neurotransmitter Release Cycle
0.0	0.2	REACTOME SIGNALING BY FGFR1 FUSION MUTANTS	Genes involved in Signaling by FGFR1 fusion mutants
0.0	0.1	REACTOME RECYCLING OF BILE ACIDS AND SALTS	Genes involved in Recycling of bile acids and salts
0.0	0.1	REACTOME RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES	Genes involved in Recruitment of NuMA to mitotic centrosomes
0.0	0.0	REACTOME SIGNALING BY CONSTITUTIVELY ACTIVE EGFR	Genes involved in Signaling by constitutively active EGFR
0.0	0.0	REACTOME NFKB IS ACTIVATED AND SIGNALS SURVIVAL	Genes involved in NF-kB is activated and signals survival
0.0	0.0	REACTOME CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE	Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
0.0	0.2	REACTOME KINESINS	Genes involved in Kinesins
0.0	0.1	REACTOME IL 6 SIGNALING	Genes involved in Interleukin-6 signaling
0.0	0.2	REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC	Genes involved in Formation of tubulin folding intermediates by CCT/TriC