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ENCSR904DTN: DNase-seq of mouse liver in constant darkness
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Results for Zic4

Z-value: 1.81

Motif logo

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Transcription factors associated with Zic4

Gene Symbol Gene ID Gene Info
Zic4
ENSMUSG00000036972.8 zinc finger protein of the cerebellum 4

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE Gene Distance Association probability Pearson corr. coef. P-value Plot
chr9_91370473_91370649Zic44430.716223-0.276.0e-01Click!
chr9_91362060_91362437Zic41650.8561980.226.7e-01Click!

Activity of the Zic4 motif across conditions

Conditions sorted by the z-value of the Zic4 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE) Target Score Top associated gene Gene Info Distance of CRE to TSS CRE/Gene association probability
chr13_60681580_60681975 5.93 Dapk1
 death associated protein kinase 1
 14636
 0.17
chr13_60680911_60681084 1.59 Dapk1
 death associated protein kinase 1
 15416
 0.17
chr13_60681310_60681461 1.29 Dapk1
 death associated protein kinase 1
 15028
 0.17
chr6_72607199_72607442 1.25 Retsat
 retinol saturase (all trans retinol 13,14 reductase)
 675
 0.43
chr13_10355578_10355729 1.18 Gm26861
 predicted gene, 26861
 1942
 0.37
chr7_13007324_13007475 1.01 Zbtb45
 zinc finger and BTB domain containing 45
 2401
 0.12
chr13_60682029_60682204 0.83 Dapk1
 death associated protein kinase 1
 14297
 0.17
chr12_24651113_24651273 0.64 Klf11
 Kruppel-like factor 11
 81
 0.96
chr6_90736325_90736476 0.63 Iqsec1
 IQ motif and Sec7 domain 1
 287
 0.9
chr7_127804168_127804541 0.59 9430064I24Rik
 RIKEN cDNA 9430064I24 gene
 1592
 0.16
chr11_102777578_102777754 0.57 Adam11
 a disintegrin and metallopeptidase domain 11
 1112
 0.37
chr13_54081500_54081675 0.57 Sfxn1
 sideroflexin 1
 4359
 0.22
chr12_84221379_84221549 0.52 Elmsan1
 ELM2 and Myb/SANT-like domain containing 1
 2583
 0.16
chr4_144959729_144959958 0.51 Gm38074
 predicted gene, 38074
 995
 0.56
chr4_149980056_149980645 0.51 H6pd
 hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)
 20915
 0.13
chr7_3331834_3332020 0.50 Cacng7
 calcium channel, voltage-dependent, gamma subunit 7
 1028
 0.31
chr1_133527738_133527935 0.50 Gm8596
 predicted gene 8596
 1643
 0.39
chr15_67420672_67420895 0.49 1700012I11Rik
 RIKEN cDNA 1700012I11 gene
 194014
 0.03
chr18_12644066_12644542 0.45 Gm50063
 predicted gene, 50063
 60
 0.94
chr11_51915955_51916321 0.45 Gm39822
 predicted gene, 39822
 17172
 0.14
chr19_6401505_6401681 0.45 Rasgrp2
 RAS, guanyl releasing protein 2
 102
 0.92
chr17_30591215_30591503 0.45 Gm50244
 predicted gene, 50244
 149
 0.92
chr16_10395249_10395418 0.45 Tekt5
 tektin 5
 115
 0.96
chr9_115456234_115456417 0.45 Gm5921
 predicted gene 5921
 17744
 0.16
chr8_123806538_123806735 0.43 Rab4a
 RAB4A, member RAS oncogene family
 568
 0.58
chr19_47304311_47304615 0.43 Sh3pxd2a
 SH3 and PX domains 2A
 10288
 0.16
chr18_76117628_76117791 0.43 2900057B20Rik
 RIKEN cDNA 2900057B20 gene
 19238
 0.19
chr7_116307697_116308006 0.43 Plekha7
 pleckstrin homology domain containing, family A member 7
 199
 0.91
chr12_102522079_102522241 0.42 Chga
 chromogranin A
 32809
 0.12
chr5_120560470_120560640 0.42 2510016D11Rik
 RIKEN cDNA 2510016D11 gene
 7516
 0.1
chr7_98779046_98779213 0.42 Gm44934
 predicted gene 44934
 44048
 0.1
chr12_57575989_57576174 0.41 Ttc6
 tetratricopeptide repeat domain 6
 264
 0.9
chr8_117747363_117747696 0.41 Gm31774
 predicted gene, 31774
 731
 0.61
chr11_101667268_101667443 0.40 Arl4d
 ADP-ribosylation factor-like 4D
 1814
 0.19
chr19_26733168_26733326 0.40 Smarca2
 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
 3248
 0.31
chr2_30966491_30966663 0.39 Tor1a
 torsin family 1, member A (torsin A)
 1295
 0.32
chr11_116855946_116856130 0.39 Mfsd11
 major facilitator superfamily domain containing 11
 1960
 0.2
chr19_8841055_8841224 0.38 Bscl2
 Berardinelli-Seip congenital lipodystrophy 2 (seipin)
 604
 0.37
chr5_27677458_27677616 0.38 Paxip1
 PAX interacting (with transcription-activation domain) protein 1
 73758
 0.1
chr11_60465981_60466150 0.38 Myo15
 myosin XV
 3274
 0.13
chr3_97818935_97819103 0.38 Pde4dip
 phosphodiesterase 4D interacting protein (myomegalin)
 5602
 0.23
chr19_4943305_4943466 0.38 Peli3
 pellino 3
 258
 0.82
chr2_131910128_131910298 0.38 Prn
 prion protein readthrough transcript
 256
 0.49
chr4_140001273_140001424 0.37 Klhdc7a
 kelch domain containing 7A
 33322
 0.14
chr10_79616142_79616293 0.37 C2cd4c
 C2 calcium-dependent domain containing 4C
 2192
 0.15
chr7_67061880_67062042 0.36 Adamts17
 a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 17
 14490
 0.18
chr10_68454663_68454821 0.36 Cabcoco1
 ciliary associated calcium binding coiled-coil 1
 71025
 0.1
chr11_113143909_113144540 0.36 2610035D17Rik
 RIKEN cDNA 2610035D17 gene
 28853
 0.23
chr11_69605770_69605921 0.36 Atp1b2
 ATPase, Na+/K+ transporting, beta 2 polypeptide
 16
 0.92
chr5_103693522_103693673 0.36 Aff1
 AF4/FMR2 family, member 1
 1223
 0.43
chr2_154712310_154712496 0.36 Gm14215
 predicted gene 14215
 1319
 0.32
chr11_78422158_78422337 0.35 Slc13a2
 solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2
 30
 0.95
chr13_46727661_46727812 0.35 Nup153
 nucleoporin 153
 204
 0.93
chr19_30145550_30145701 0.35 Gldc
 glycine decarboxylase
 394
 0.86
chr11_117810052_117810409 0.34 Syngr2
 synaptogyrin 2
 518
 0.39
chr15_88866027_88866463 0.34 Pim3
 proviral integration site 3
 1325
 0.34
chr12_113878948_113879099 0.33 Ighv2-8
 immunoglobulin heavy variable V2-8
 1229
 0.33
chr4_133049992_133050178 0.33 Ahdc1
 AT hook, DNA binding motif, containing 1
 10592
 0.19
chr4_148160555_148160717 0.32 Fbxo2
 F-box protein 2
 15
 0.65
chr8_84937365_84937533 0.32 Mast1
 microtubule associated serine/threonine kinase 1
 90
 0.91
chr11_97434945_97435114 0.32 Arhgap23
 Rho GTPase activating protein 23
 1256
 0.42
chr1_87041212_87041509 0.31 Gm37447
 predicted gene, 37447
 4637
 0.13
chr11_116175159_116175523 0.31 Acox1
 acyl-Coenzyme A oxidase 1, palmitoyl
 5873
 0.1
chr15_36471981_36472313 0.31 Ankrd46
 ankyrin repeat domain 46
 24568
 0.12
chr13_34037312_34037494 0.31 Bphl
 biphenyl hydrolase-like (serine hydrolase, breast epithelial mucin-associated antigen)
 194
 0.89
chr14_61680870_61681697 0.30 Gm37472
 predicted gene, 37472
 211
 0.83
chr2_66256344_66256524 0.30 Ttc21b
 tetratricopeptide repeat domain 21B
 158
 0.96
chr12_100343836_100343987 0.30 Ttc7b
 tetratricopeptide repeat domain 7B
 5615
 0.19
chr19_6987284_6987440 0.30 Vegfb
 vascular endothelial growth factor B
 222
 0.81
chr2_25262755_25263227 0.30 Tprn
 taperin
 373
 0.59
chr19_5924482_5924697 0.30 Cdc42ep2
 CDC42 effector protein (Rho GTPase binding) 2
 227
 0.83
chr13_119713466_119713785 0.29 Gm48342
 predicted gene, 48342
 9076
 0.11
chr5_37717722_37717888 0.29 Stk32b
 serine/threonine kinase 32B
 634
 0.76
chr5_110135214_110135545 0.29 Chfr
 checkpoint with forkhead and ring finger domains
 463
 0.65
chr7_39967880_39968059 0.29 Gm44992
 predicted gene 44992
 10105
 0.24
chr2_155053105_155053256 0.29 a
 nonagouti
 5565
 0.16
chr8_12719084_12719404 0.28 Gm15348
 predicted gene 15348
 117
 0.96
chr4_108217549_108217700 0.28 Zyg11a
 zyg-11 family member A, cell cycle regulator
 298
 0.88
chr11_4098038_4098510 0.28 Mtfp1
 mitochondrial fission process 1
 2829
 0.13
chr14_70051978_70052160 0.28 Gm33524
 predicted gene, 33524
 5298
 0.19
chr2_167661426_167661577 0.28 Gm20431
 predicted gene 20431
 5
 0.5
chr11_20826808_20826959 0.27 Lgalsl
 lectin, galactoside binding-like
 3872
 0.18
chr2_32681906_32682535 0.27 Fpgs
 folylpolyglutamyl synthetase
 2784
 0.1
chr10_88507513_88507686 0.27 Chpt1
 choline phosphotransferase 1
 3526
 0.19
chr2_156433566_156433753 0.27 Epb41l1
 erythrocyte membrane protein band 4.1 like 1
 12547
 0.09
chr19_5016908_5017071 0.27 Slc29a2
 solute carrier family 29 (nucleoside transporters), member 2
 6871
 0.07
chr1_72009620_72009955 0.27 4933417E11Rik
 RIKEN cDNA 4933417E11 gene
 4592
 0.18
chr17_12381963_12382316 0.27 Plg
 plasminogen
 3480
 0.2
chr2_118111415_118111787 0.27 Thbs1
 thrombospondin 1
 275
 0.6
chr19_36627251_36627417 0.27 Hectd2os
 Hectd2, opposite strand
 1310
 0.49
chr5_111620604_111620778 0.26 Gm42489
 predicted gene 42489
 27075
 0.18
chr6_113866107_113866258 0.26 Atp2b2
 ATPase, Ca++ transporting, plasma membrane 2
 25188
 0.15
chr1_182620497_182620688 0.26 Capn8
 calpain 8
 55554
 0.1
chr8_95067717_95067883 0.26 Drc7
 dynein regulatory complex subunit 7
 6279
 0.11
chr19_8662448_8662612 0.26 9830166K06Rik
 RIKEN cDNA 9830166K06 gene
 805
 0.34
chr6_113891432_113891618 0.25 Atp2b2
 ATPase, Ca++ transporting, plasma membrane 2
 14
 0.98
chr12_51471684_51471879 0.25 Gm18503
 predicted gene, 18503
 45545
 0.14
chr19_4476935_4477185 0.25 Syt12
 synaptotagmin XII
 66
 0.96
chr7_13006960_13007136 0.25 Zbtb45
 zinc finger and BTB domain containing 45
 2752
 0.11
chr4_138455294_138455445 0.25 Camk2n1
 calcium/calmodulin-dependent protein kinase II inhibitor 1
 1055
 0.45
chr11_23124284_23124721 0.25 1700061J23Rik
 RIKEN cDNA 1700061J23 gene
 27638
 0.14
chr9_53825348_53825526 0.25 Slc35f2
 solute carrier family 35, member F2
 14720
 0.17
chr6_118478873_118479106 0.25 Zfp9
 zinc finger protein 9
 331
 0.85
chr5_137586972_137587155 0.25 Tfr2
 transferrin receptor 2
 3778
 0.08
chr7_25892258_25892429 0.25 Cyp2b10
 cytochrome P450, family 2, subfamily b, polypeptide 10
 5277
 0.11
chr14_65785434_65785772 0.25 Pbk
 PDZ binding kinase
 20234
 0.18
chr9_103471712_103471904 0.25 Gm16252
 predicted gene 16252
 276
 0.85
chr17_31631886_31632186 0.24 Cbs
 cystathionine beta-synthase
 1128
 0.31
chr13_119713859_119714010 0.24 Gm48342
 predicted gene, 48342
 9385
 0.11
chr2_118883474_118883639 0.24 Ivd
 isovaleryl coenzyme A dehydrogenase
 7123
 0.14
chr5_34636833_34637005 0.24 Mfsd10
 major facilitator superfamily domain containing 10
 78
 0.95
chr11_87578374_87578544 0.24 Septin4
 septin 4
 3
 0.97
chr8_84902850_84903029 0.24 Klf1
 Kruppel-like factor 1 (erythroid)
 1011
 0.26
chr2_92383563_92383841 0.24 1700029I15Rik
 RIKEN cDNA 1700029I15 gene
 784
 0.45
chr13_117602276_117602441 0.24 Hcn1
 hyperpolarization activated cyclic nucleotide gated potassium channel 1
 38
 0.99
chr12_82333592_82333979 0.24 Sipa1l1
 signal-induced proliferation-associated 1 like 1
 8482
 0.29
chr4_148903004_148903163 0.23 Casz1
 castor zinc finger 1
 1934
 0.31
chr4_144916418_144916763 0.23 Dhrs3
 dehydrogenase/reductase (SDR family) member 3
 2289
 0.32
chr15_101074200_101074369 0.23 Fignl2
 fidgetin-like 2
 4283
 0.16
chr1_86415976_86416160 0.23 Nmur1
 neuromedin U receptor 1
 10160
 0.1
chr3_106514922_106515103 0.23 Dennd2d
 DENN/MADD domain containing 2D
 21837
 0.11
chr6_121878379_121878709 0.23 Mug1
 murinoglobulin 1
 7033
 0.2
chr8_68062613_68062915 0.23 Psd3
 pleckstrin and Sec7 domain containing 3
 478
 0.86
chr4_138262391_138262595 0.23 Kif17
 kinesin family member 17
 6
 0.96
chr9_120933701_120933852 0.23 Ctnnb1
 catenin (cadherin associated protein), beta 1
 42
 0.95
chr17_7443940_7444098 0.22 Gm6553
 predicted gene 6553
 13777
 0.19
chr13_55321508_55321662 0.22 Rab24
 RAB24, member RAS oncogene family
 194
 0.71
chr7_130577474_130577931 0.22 Tacc2
 transforming, acidic coiled-coil containing protein 2
 218
 0.92
chr15_83563229_83563380 0.22 Tspo
 translocator protein
 288
 0.63
chr1_45627972_45628123 0.22 Gm8304
 predicted gene 8304
 26021
 0.17
chr11_95397945_95398308 0.22 Slc35b1
 solute carrier family 35, member B1
 8141
 0.13
chr5_118004722_118004887 0.22 Gm42545
 predicted gene 42545
 22566
 0.12
chr15_87045730_87045890 0.22 Gm23416
 predicted gene, 23416
 23183
 0.18
chr4_122455220_122455373 0.22 Gm12895
 predicted gene 12895
 86
 0.98
chr2_132869809_132870198 0.22 Lrrn4
 leucine rich repeat neuronal 4
 10888
 0.13
chr17_28274865_28275039 0.21 Ppard
 peroxisome proliferator activator receptor delta
 2833
 0.16
chr15_78178475_78178665 0.21 Gm49694
 predicted gene, 49694
 4109
 0.16
chr10_80611135_80611333 0.21 Scamp4
 secretory carrier membrane protein 4
 989
 0.27
chr8_94942711_94942867 0.21 Adgrg5
 adhesion G protein-coupled receptor G5
 8622
 0.12
chr4_135508053_135508210 0.21 Gm25317
 predicted gene, 25317
 4348
 0.14
chr10_75160623_75160782 0.21 Bcr
 BCR activator of RhoGEF and GTPase
 342
 0.9
chr12_26415244_26415422 0.21 Rnf144a
 ring finger protein 144A
 79
 0.79
chr9_21161475_21161850 0.21 Pde4a
 phosphodiesterase 4A, cAMP specific
 4052
 0.12
chr16_4268162_4268330 0.21 Gm5766
 predicted gene 5766
 37945
 0.13
chr8_122660121_122660272 0.21 Cbfa2t3
 CBFA2/RUNX1 translocation partner 3
 13730
 0.09
chr10_60005449_60005609 0.21 Ascc1
 activating signal cointegrator 1 complex subunit 1
 2202
 0.26
chr10_97249598_97249782 0.21 Gm18515
 predicted gene, 18515
 7778
 0.26
chr4_122122855_122123016 0.21 Gm12896
 predicted gene 12896
 88
 0.98
chr2_109693213_109693439 0.21 Bdnf
 brain derived neurotrophic factor
 237
 0.93
chr17_31637083_31637756 0.21 Cbs
 cystathionine beta-synthase
 181
 0.89
chr7_129649085_129649245 0.21 Gm39094
 predicted gene, 39094
 9763
 0.2
chr11_69340671_69341048 0.21 Rnf227
 ring finger protein 227
 50
 0.93
chr9_123665785_123665936 0.21 Gm17200
 predicted gene 17200
 12236
 0.09
chr18_46713280_46713447 0.20 Cdo1
 cysteine dioxygenase 1, cytosolic
 14666
 0.13
chr18_35662151_35662309 0.20 Spata24
 spermatogenesis associated 24
 44
 0.51
chr11_74638791_74638959 0.20 Cluh
 clustered mitochondria (cluA/CLU1) homolog
 10620
 0.15
chr12_102623965_102624273 0.20 Gm20069
 predicted gene, 20069
 11439
 0.13
chr13_60479839_60480430 0.20 Gm48500
 predicted gene, 48500
 1164
 0.45
chr6_42325328_42325493 0.20 Fam131b
 family with sequence similarity 131, member B
 767
 0.44
chr14_22019673_22019870 0.20 Lrmda
 leucine rich melanocyte differentiation associated
 50
 0.96
chr1_92647884_92648048 0.20 Otos
 otospiralin
 288
 0.83
chr2_152081883_152082034 0.20 Scrt2
 scratch family zinc finger 2
 429
 0.78
chr9_103258204_103258373 0.20 1300017J02Rik
 RIKEN cDNA 1300017J02 gene
 1262
 0.42
chr5_125271875_125272026 0.20 Gm32585
 predicted gene, 32585
 865
 0.57
chr17_31390196_31390347 0.20 Pde9a
 phosphodiesterase 9A
 3977
 0.17
chr14_20794215_20794517 0.20 Gm30108
 predicted gene, 30108
 127
 0.69
chr19_28975451_28975625 0.20 Gm3621
 predicted gene 3621
 2499
 0.17
chr6_128736252_128736414 0.20 Gm43907
 predicted gene, 43907
 8311
 0.11
chr1_180991444_180991626 0.20 Ephx1
 epoxide hydrolase 1, microsomal
 4635
 0.11
chrX_101419042_101419230 0.20 Zmym3
 zinc finger, MYM-type 3
 662
 0.61
chr15_102126408_102126761 0.20 Spryd3
 SPRY domain containing 3
 2300
 0.17
chr11_50431056_50431230 0.20 Rufy1
 RUN and FYVE domain containing 1
 18
 0.98
chr10_70599538_70599732 0.19 Phyhipl
 phytanoyl-CoA hydroxylase interacting protein-like
 344
 0.91
chr4_116008423_116008814 0.19 Faah
 fatty acid amide hydrolase
 8550
 0.14
chr13_7428915_7429066 0.19 Gm36074
 predicted gene, 36074
 17519
 0.27
chr17_56935189_56935340 0.19 Mllt1
 myeloid/lymphoid or mixed-lineage leukemia; translocated to, 1
 151
 0.92
chr9_30124659_30124991 0.19 Gm47677
 predicted gene, 47677
 42750
 0.18
chr10_125949154_125949327 0.19 Lrig3
 leucine-rich repeats and immunoglobulin-like domains 3
 16928
 0.28
chr9_35139662_35139830 0.19 Gm24262
 predicted gene, 24262
 4890
 0.14
chr12_113859003_113859160 0.19 Ighv5-18
 immunoglobulin heavy variable V5-18
 17158
 0.11
chr16_85173682_85173850 0.19 App
 amyloid beta (A4) precursor protein
 0
 0.98
chr6_147042911_147043077 0.19 Mrps35
 mitochondrial ribosomal protein S35
 230
 0.89
chr15_76369272_76369423 0.19 Hgh1
 HGH1 homolog
 134
 0.88
chr2_179290486_179290655 0.19 Gm14293
 predicted gene 14293
 50080
 0.15
chr16_20537030_20537361 0.19 Ap2m1
 adaptor-related protein complex 2, mu 1 subunit
 417
 0.62
chr1_74338040_74338254 0.19 Pnkd
 paroxysmal nonkinesiogenic dyskinesia
 5484
 0.1
chr15_81849441_81849616 0.19 Gm8444
 predicted gene 8444
 5815
 0.1
chr11_94732887_94733059 0.19 Cdc34b
 cell division cycle 34B
 8809
 0.11
chr11_102753302_102753453 0.19 Adam11
 a disintegrin and metallopeptidase domain 11
 8062
 0.11
chr18_5085122_5085283 0.19 Svil
 supervillin
 9179
 0.28
chr3_89436568_89436763 0.19 Pbxip1
 pre B cell leukemia transcription factor interacting protein 1
 41
 0.94
chr8_20557902_20558131 0.19 Gm21182
 predicted gene, 21182
 530
 0.76
chr3_107631354_107631565 0.19 Gm10961
 predicted gene 10961
 137
 0.63
chr5_66618891_66619162 0.18 Apbb2
 amyloid beta (A4) precursor protein-binding, family B, member 2
 242
 0.91
chr15_36609144_36609341 0.18 Pabpc1
 poly(A) binding protein, cytoplasmic 1
 269
 0.88
chr2_164952558_164952709 0.18 Mmp9
 matrix metallopeptidase 9
 1753
 0.24
chr15_83724999_83725153 0.18 Scube1
 signal peptide, CUB domain, EGF-like 1
 55
 0.98
chr1_181475618_181475786 0.18 Ccdc121
 coiled-coil domain containing 121
 35749
 0.14
chr5_121546456_121546786 0.18 Mapkapk5
 MAP kinase-activated protein kinase 5
 716
 0.35
chr18_34373553_34373724 0.18 Reep5
 receptor accessory protein 5
 269
 0.91

Histogram of CRE-TSS distances for CREs targeted by :

Histogram of

Rank distribution of CRE target scores:

Histogram of target CRE score.

Distribution of target CREs across different genomic regions:

Weighted Piechart of Weighted Piechart of Weighted Piechart of

Network of associatons between targets according to the STRING database.

First level regulatory network of Zic4

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0045218 zonula adherens maintenance(GO:0045218)
0.1 0.4 GO:0070428 regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070428)
0.1 0.3 GO:1903286 regulation of potassium ion import(GO:1903286) positive regulation of potassium ion import(GO:1903288)
0.1 1.6 GO:2000310 regulation of N-methyl-D-aspartate selective glutamate receptor activity(GO:2000310)
0.1 0.3 GO:0006546 glycine catabolic process(GO:0006546) glycine decarboxylation via glycine cleavage system(GO:0019464)
0.1 0.3 GO:0061043 regulation of vascular wound healing(GO:0061043)
0.1 0.3 GO:1902630 regulation of membrane hyperpolarization(GO:1902630)
0.1 0.1 GO:1903275 positive regulation of sodium ion export(GO:1903275) positive regulation of sodium ion export from cell(GO:1903278)
0.1 0.2 GO:0019344 cysteine biosynthetic process(GO:0019344)
0.1 0.2 GO:0007403 glial cell fate determination(GO:0007403)
0.1 0.2 GO:0010751 negative regulation of nitric oxide mediated signal transduction(GO:0010751)
0.1 0.2 GO:0007228 positive regulation of hh target transcription factor activity(GO:0007228)
0.1 0.3 GO:0032482 Rab protein signal transduction(GO:0032482)
0.1 0.2 GO:0071873 response to norepinephrine(GO:0071873)
0.1 0.1 GO:0035887 aortic smooth muscle cell differentiation(GO:0035887)
0.1 0.2 GO:1902564 negative regulation of neutrophil activation(GO:1902564)
0.1 0.2 GO:0090210 regulation of establishment of blood-brain barrier(GO:0090210)
0.1 0.2 GO:0061091 regulation of phospholipid translocation(GO:0061091) positive regulation of phospholipid translocation(GO:0061092)
0.1 0.7 GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0000083)
0.1 0.2 GO:0035359 negative regulation of peroxisome proliferator activated receptor signaling pathway(GO:0035359)
0.1 0.2 GO:0042891 antibiotic transport(GO:0042891)
0.1 0.3 GO:0048840 otolith development(GO:0048840)
0.1 0.8 GO:0032012 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.0 0.2 GO:0007412 axon target recognition(GO:0007412)
0.0 0.1 GO:0006393 termination of mitochondrial transcription(GO:0006393)
0.0 0.2 GO:2000370 positive regulation of clathrin-mediated endocytosis(GO:2000370)
0.0 0.1 GO:0010481 epidermal cell division(GO:0010481) regulation of epidermal cell division(GO:0010482)
0.0 0.0 GO:1903753 negative regulation of p38MAPK cascade(GO:1903753)
0.0 0.2 GO:0090666 scaRNA localization to Cajal body(GO:0090666)
0.0 0.2 GO:0070885 negative regulation of calcineurin-NFAT signaling cascade(GO:0070885)
0.0 0.1 GO:0048549 positive regulation of pinocytosis(GO:0048549)
0.0 0.1 GO:0042851 L-alanine metabolic process(GO:0042851)
0.0 0.2 GO:2000049 positive regulation of cell-cell adhesion mediated by cadherin(GO:2000049)
0.0 0.2 GO:0072383 plus-end-directed vesicle transport along microtubule(GO:0072383) plus-end-directed organelle transport along microtubule(GO:0072386)
0.0 0.1 GO:0002125 maternal aggressive behavior(GO:0002125)
0.0 0.3 GO:0099515 actin filament-based transport(GO:0099515)
0.0 0.3 GO:0021798 forebrain dorsal/ventral pattern formation(GO:0021798)
0.0 0.2 GO:2000623 regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000622) negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000623)
0.0 0.3 GO:0007207 adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway(GO:0007197) phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway(GO:0007207)
0.0 0.1 GO:0048207 vesicle targeting, rough ER to cis-Golgi(GO:0048207) COPII vesicle coating(GO:0048208)
0.0 0.1 GO:0035973 aggrephagy(GO:0035973)
0.0 0.2 GO:0018076 N-terminal peptidyl-lysine acetylation(GO:0018076)
0.0 0.1 GO:0035483 gastric emptying(GO:0035483)
0.0 0.1 GO:0070164 negative regulation of adiponectin secretion(GO:0070164)
0.0 0.1 GO:0019626 short-chain fatty acid catabolic process(GO:0019626)
0.0 0.1 GO:0034773 histone H4-K20 trimethylation(GO:0034773)
0.0 0.4 GO:0046831 regulation of RNA export from nucleus(GO:0046831)
0.0 0.1 GO:2000047 regulation of cell-cell adhesion mediated by cadherin(GO:2000047)
0.0 0.1 GO:0070889 platelet alpha granule organization(GO:0070889)
0.0 0.1 GO:2000741 positive regulation of mesenchymal stem cell differentiation(GO:2000741)
0.0 0.1 GO:0030208 dermatan sulfate biosynthetic process(GO:0030208)
0.0 0.0 GO:0097106 postsynaptic density organization(GO:0097106) postsynaptic density assembly(GO:0097107)
0.0 0.1 GO:0035021 negative regulation of Rac protein signal transduction(GO:0035021)
0.0 0.1 GO:0032439 endosome localization(GO:0032439)
0.0 0.1 GO:0016561 protein import into peroxisome matrix, translocation(GO:0016561)
0.0 0.2 GO:0072656 maintenance of protein location in mitochondrion(GO:0072656)
0.0 0.1 GO:1902915 negative regulation of protein K63-linked ubiquitination(GO:1900045) negative regulation of protein polyubiquitination(GO:1902915)
0.0 0.1 GO:0016095 polyprenol catabolic process(GO:0016095)
0.0 0.1 GO:0098902 regulation of membrane depolarization during action potential(GO:0098902)
0.0 0.1 GO:0097296 activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:0097296)
0.0 0.1 GO:0060431 primary lung bud formation(GO:0060431)
0.0 0.1 GO:0090309 positive regulation of methylation-dependent chromatin silencing(GO:0090309)
0.0 0.5 GO:0042572 retinol metabolic process(GO:0042572)
0.0 0.3 GO:0030953 astral microtubule organization(GO:0030953)
0.0 0.1 GO:0045715 negative regulation of low-density lipoprotein particle receptor biosynthetic process(GO:0045715)
0.0 0.1 GO:0046951 ketone body biosynthetic process(GO:0046951)
0.0 0.1 GO:0045896 regulation of transcription during mitosis(GO:0045896) positive regulation of transcription during mitosis(GO:0045897)
0.0 0.1 GO:1903599 positive regulation of mitophagy(GO:1903599)
0.0 0.1 GO:0048696 regulation of collateral sprouting in absence of injury(GO:0048696)
0.0 0.1 GO:1902071 regulation of hypoxia-inducible factor-1alpha signaling pathway(GO:1902071)
0.0 0.1 GO:2000664 positive regulation of interleukin-5 secretion(GO:2000664) positive regulation of interleukin-13 secretion(GO:2000667)
0.0 0.2 GO:0071578 zinc II ion transmembrane import(GO:0071578)
0.0 0.1 GO:0071442 positive regulation of histone H3-K14 acetylation(GO:0071442)
0.0 0.2 GO:0031274 positive regulation of pseudopodium assembly(GO:0031274)
0.0 0.1 GO:0034139 regulation of toll-like receptor 3 signaling pathway(GO:0034139)
0.0 0.1 GO:0019355 nicotinamide nucleotide biosynthetic process from aspartate(GO:0019355) 'de novo' NAD biosynthetic process from aspartate(GO:0034628)
0.0 0.1 GO:0015772 disaccharide transport(GO:0015766) sucrose transport(GO:0015770) oligosaccharide transport(GO:0015772)
0.0 0.1 GO:0030638 polyketide metabolic process(GO:0030638) aminoglycoside antibiotic metabolic process(GO:0030647) daunorubicin metabolic process(GO:0044597) doxorubicin metabolic process(GO:0044598)
0.0 0.1 GO:0051596 methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione(GO:0019243) methylglyoxal catabolic process(GO:0051596) methylglyoxal catabolic process to lactate(GO:0061727)
0.0 0.1 GO:1901420 negative regulation of response to alcohol(GO:1901420)
0.0 0.1 GO:1900122 positive regulation of receptor binding(GO:1900122)
0.0 0.0 GO:0090296 regulation of mitochondrial DNA replication(GO:0090296)
0.0 0.1 GO:0035589 G-protein coupled purinergic nucleotide receptor signaling pathway(GO:0035589)
0.0 0.1 GO:0060221 retinal rod cell differentiation(GO:0060221)
0.0 0.0 GO:0060066 oviduct development(GO:0060066)
0.0 0.1 GO:0061113 pancreas morphogenesis(GO:0061113)
0.0 0.1 GO:0071462 cellular response to water stimulus(GO:0071462)
0.0 0.1 GO:0061511 centriole elongation(GO:0061511)
0.0 0.1 GO:2000562 negative regulation of CD4-positive, alpha-beta T cell proliferation(GO:2000562)
0.0 0.1 GO:1903715 regulation of aerobic respiration(GO:1903715)
0.0 0.1 GO:1904059 regulation of locomotor rhythm(GO:1904059)
0.0 0.1 GO:0006561 proline biosynthetic process(GO:0006561)
0.0 0.1 GO:1900738 positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathway(GO:1900738)
0.0 0.0 GO:0006501 C-terminal protein lipidation(GO:0006501)
0.0 0.1 GO:0046959 habituation(GO:0046959)
0.0 0.0 GO:2000698 positive regulation of epithelial cell differentiation involved in kidney development(GO:2000698)
0.0 0.0 GO:0014858 positive regulation of skeletal muscle cell proliferation(GO:0014858)
0.0 0.1 GO:0009182 purine deoxyribonucleoside diphosphate metabolic process(GO:0009182) dGDP metabolic process(GO:0046066)
0.0 0.1 GO:0046271 phenylpropanoid catabolic process(GO:0046271)
0.0 0.0 GO:1901187 regulation of ephrin receptor signaling pathway(GO:1901187)
0.0 0.0 GO:2000974 negative regulation of pro-B cell differentiation(GO:2000974)
0.0 0.0 GO:0044857 plasma membrane raft assembly(GO:0044854) plasma membrane raft organization(GO:0044857)
0.0 0.1 GO:0097118 neuroligin clustering involved in postsynaptic membrane assembly(GO:0097118)
0.0 0.1 GO:0035511 oxidative DNA demethylation(GO:0035511)
0.0 0.1 GO:0032876 negative regulation of DNA endoreduplication(GO:0032876)
0.0 0.0 GO:0097460 ferrous iron import into cell(GO:0097460)
0.0 0.1 GO:0061144 alveolar secondary septum development(GO:0061144)
0.0 0.1 GO:0060528 secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development(GO:0060528)
0.0 0.1 GO:0090400 stress-induced premature senescence(GO:0090400)
0.0 0.1 GO:0060161 positive regulation of dopamine receptor signaling pathway(GO:0060161)
0.0 0.0 GO:0045404 interleukin-4 biosynthetic process(GO:0042097) regulation of interleukin-4 biosynthetic process(GO:0045402) positive regulation of interleukin-4 biosynthetic process(GO:0045404)
0.0 0.0 GO:1902566 regulation of eosinophil degranulation(GO:0043309) regulation of eosinophil activation(GO:1902566)
0.0 0.1 GO:0006189 'de novo' IMP biosynthetic process(GO:0006189)
0.0 0.1 GO:0070779 D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
0.0 0.1 GO:0006597 spermine biosynthetic process(GO:0006597)
0.0 0.0 GO:0036151 phosphatidylcholine acyl-chain remodeling(GO:0036151)
0.0 0.1 GO:2001199 negative regulation of dendritic cell differentiation(GO:2001199)
0.0 0.0 GO:0019448 cysteine catabolic process(GO:0009093) L-cysteine catabolic process(GO:0019448) L-cysteine metabolic process(GO:0046439)
0.0 0.1 GO:0046469 platelet activating factor biosynthetic process(GO:0006663) platelet activating factor metabolic process(GO:0046469)
0.0 0.0 GO:1900739 regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900739) positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900740)
0.0 0.0 GO:0044339 canonical Wnt signaling pathway involved in osteoblast differentiation(GO:0044339)
0.0 0.1 GO:2000189 positive regulation of cholesterol homeostasis(GO:2000189)
0.0 0.1 GO:1902231 positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage(GO:1902231)
0.0 0.2 GO:0006516 glycoprotein catabolic process(GO:0006516)
0.0 0.0 GO:0022009 central nervous system vasculogenesis(GO:0022009)
0.0 0.0 GO:0044333 Wnt signaling pathway involved in digestive tract morphogenesis(GO:0044333)
0.0 0.1 GO:0000244 spliceosomal tri-snRNP complex assembly(GO:0000244)
0.0 0.1 GO:0007066 female meiosis sister chromatid cohesion(GO:0007066)
0.0 0.0 GO:0070368 positive regulation of hepatocyte differentiation(GO:0070368)
0.0 0.0 GO:1904526 regulation of microtubule binding(GO:1904526) positive regulation of microtubule binding(GO:1904528)
0.0 0.0 GO:0000414 regulation of histone H3-K36 methylation(GO:0000414)
0.0 0.1 GO:0060633 negative regulation of transcription initiation from RNA polymerase II promoter(GO:0060633) negative regulation of DNA-templated transcription, initiation(GO:2000143)
0.0 0.2 GO:0051444 negative regulation of ubiquitin-protein transferase activity(GO:0051444)
0.0 0.1 GO:2000394 positive regulation of lamellipodium morphogenesis(GO:2000394)
0.0 0.1 GO:0046726 positive regulation by virus of viral protein levels in host cell(GO:0046726)
0.0 0.1 GO:0048170 positive regulation of long-term neuronal synaptic plasticity(GO:0048170)
0.0 0.0 GO:0033159 negative regulation of protein import into nucleus, translocation(GO:0033159)
0.0 0.1 GO:0032754 positive regulation of interleukin-5 production(GO:0032754)
0.0 0.0 GO:2001274 negative regulation of glucose import in response to insulin stimulus(GO:2001274)
0.0 0.1 GO:0051121 hepoxilin metabolic process(GO:0051121) hepoxilin biosynthetic process(GO:0051122)
0.0 0.1 GO:0051697 protein delipidation(GO:0051697)
0.0 0.0 GO:0035609 C-terminal protein deglutamylation(GO:0035609)
0.0 0.0 GO:0021699 cerebellar cortex maturation(GO:0021699)
0.0 0.1 GO:0045053 protein retention in Golgi apparatus(GO:0045053)
0.0 0.1 GO:0030174 regulation of DNA-dependent DNA replication initiation(GO:0030174)
0.0 0.3 GO:0048488 synaptic vesicle endocytosis(GO:0048488)
0.0 0.1 GO:0061179 negative regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0061179)
0.0 0.1 GO:1902459 positive regulation of stem cell population maintenance(GO:1902459)
0.0 0.0 GO:0072201 negative regulation of mesenchymal cell proliferation(GO:0072201)
0.0 0.1 GO:0016255 attachment of GPI anchor to protein(GO:0016255)
0.0 0.3 GO:0071108 protein K48-linked deubiquitination(GO:0071108)
0.0 0.1 GO:0010724 regulation of definitive erythrocyte differentiation(GO:0010724)
0.0 0.1 GO:0036233 glycine import(GO:0036233)
0.0 0.2 GO:2000311 regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000311)
0.0 0.1 GO:0017196 N-terminal peptidyl-methionine acetylation(GO:0017196)
0.0 0.2 GO:0046548 retinal rod cell development(GO:0046548)
0.0 0.1 GO:1903025 regulation of RNA polymerase II regulatory region sequence-specific DNA binding(GO:1903025)
0.0 0.0 GO:1902498 regulation of protein autoubiquitination(GO:1902498)
0.0 0.0 GO:0090241 negative regulation of histone H4 acetylation(GO:0090241)
0.0 0.1 GO:0048194 Golgi vesicle budding(GO:0048194)
0.0 0.0 GO:0070340 detection of bacterial lipopeptide(GO:0070340)
0.0 0.1 GO:0090166 Golgi disassembly(GO:0090166)
0.0 0.1 GO:0035745 T-helper 2 cell cytokine production(GO:0035745)
0.0 0.0 GO:1903279 regulation of calcium:sodium antiporter activity(GO:1903279)
0.0 0.1 GO:0008655 pyrimidine-containing compound salvage(GO:0008655) pyrimidine nucleoside salvage(GO:0043097)
0.0 0.1 GO:0090308 regulation of methylation-dependent chromatin silencing(GO:0090308)
0.0 0.0 GO:2000507 positive regulation of energy homeostasis(GO:2000507)
0.0 0.1 GO:0090148 membrane fission(GO:0090148)
0.0 0.1 GO:2001140 regulation of phospholipid transport(GO:2001138) positive regulation of phospholipid transport(GO:2001140)
0.0 0.1 GO:1902894 negative regulation of pri-miRNA transcription from RNA polymerase II promoter(GO:1902894)
0.0 0.0 GO:0014053 negative regulation of gamma-aminobutyric acid secretion(GO:0014053)
0.0 0.0 GO:0070973 protein localization to endoplasmic reticulum exit site(GO:0070973)
0.0 0.1 GO:0033762 response to glucagon(GO:0033762)
0.0 0.0 GO:0002017 regulation of blood volume by renal aldosterone(GO:0002017)
0.0 0.1 GO:0015867 ATP transport(GO:0015867)
0.0 0.1 GO:2000188 regulation of cholesterol homeostasis(GO:2000188)
0.0 0.0 GO:0010956 negative regulation of calcidiol 1-monooxygenase activity(GO:0010956)
0.0 0.0 GO:0009449 gamma-aminobutyric acid biosynthetic process(GO:0009449)
0.0 0.0 GO:0021914 negative regulation of smoothened signaling pathway involved in ventral spinal cord patterning(GO:0021914)
0.0 0.1 GO:0060033 anatomical structure regression(GO:0060033)
0.0 0.0 GO:0035694 mitochondrial protein catabolic process(GO:0035694)
0.0 0.1 GO:0010991 negative regulation of SMAD protein complex assembly(GO:0010991)
0.0 0.0 GO:0033353 S-adenosylmethionine cycle(GO:0033353)
0.0 0.0 GO:0001828 inner cell mass cellular morphogenesis(GO:0001828)
0.0 0.0 GO:0006562 proline catabolic process(GO:0006562)
0.0 0.0 GO:0030091 protein repair(GO:0030091)
0.0 0.0 GO:0016554 cytidine to uridine editing(GO:0016554)
0.0 0.0 GO:2001166 regulation of histone H2B ubiquitination(GO:2001166) positive regulation of histone H2B ubiquitination(GO:2001168)
0.0 0.0 GO:1900194 negative regulation of oocyte maturation(GO:1900194)
0.0 0.0 GO:0035513 oxidative RNA demethylation(GO:0035513) oxidative single-stranded RNA demethylation(GO:0035553)
0.0 0.1 GO:1901897 regulation of relaxation of cardiac muscle(GO:1901897)
0.0 0.0 GO:0060375 mast cell differentiation(GO:0060374) regulation of mast cell differentiation(GO:0060375)
0.0 0.0 GO:0034770 histone H4-K20 methylation(GO:0034770)
0.0 0.0 GO:0048003 antigen processing and presentation of lipid antigen via MHC class Ib(GO:0048003) antigen processing and presentation, exogenous lipid antigen via MHC class Ib(GO:0048007)
0.0 0.2 GO:0033539 fatty acid beta-oxidation using acyl-CoA dehydrogenase(GO:0033539)
0.0 0.0 GO:1901679 pyrimidine-containing compound transmembrane transport(GO:0072531) nucleotide transmembrane transport(GO:1901679)
0.0 0.0 GO:1903377 negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903377)
0.0 0.1 GO:0006670 sphingosine metabolic process(GO:0006670)
0.0 0.1 GO:0030432 peristalsis(GO:0030432)
0.0 0.0 GO:0009436 glyoxylate catabolic process(GO:0009436)
0.0 0.0 GO:0045039 protein import into mitochondrial inner membrane(GO:0045039)
0.0 0.1 GO:0000056 ribosomal small subunit export from nucleus(GO:0000056)
0.0 0.0 GO:1903237 negative regulation of leukocyte tethering or rolling(GO:1903237)
0.0 0.0 GO:1903626 positive regulation of apoptotic DNA fragmentation(GO:1902512) positive regulation of DNA catabolic process(GO:1903626)
0.0 0.1 GO:0010961 cellular magnesium ion homeostasis(GO:0010961)
0.0 0.0 GO:0033092 positive regulation of immature T cell proliferation in thymus(GO:0033092)
0.0 0.1 GO:0060088 auditory receptor cell stereocilium organization(GO:0060088)
0.0 0.0 GO:0086043 bundle of His cell to Purkinje myocyte signaling(GO:0086028) bundle of His cell action potential(GO:0086043)
0.0 0.1 GO:0030643 cellular phosphate ion homeostasis(GO:0030643) cellular trivalent inorganic anion homeostasis(GO:0072502)
0.0 0.1 GO:0006104 succinyl-CoA metabolic process(GO:0006104)
0.0 0.0 GO:0008626 granzyme-mediated apoptotic signaling pathway(GO:0008626)
0.0 0.1 GO:0048227 plasma membrane to endosome transport(GO:0048227)
0.0 0.1 GO:0030206 chondroitin sulfate biosynthetic process(GO:0030206)
0.0 0.0 GO:0035526 retrograde transport, plasma membrane to Golgi(GO:0035526)
0.0 0.2 GO:0035066 positive regulation of histone acetylation(GO:0035066)
0.0 0.1 GO:0051451 myoblast migration(GO:0051451)
0.0 0.1 GO:0035855 megakaryocyte development(GO:0035855)
0.0 0.0 GO:1902075 cellular response to salt(GO:1902075)
0.0 0.0 GO:0002019 regulation of renal output by angiotensin(GO:0002019)
0.0 0.0 GO:0031117 positive regulation of microtubule depolymerization(GO:0031117)
0.0 0.0 GO:0043622 cortical microtubule organization(GO:0043622)
0.0 0.2 GO:0043011 myeloid dendritic cell differentiation(GO:0043011)
0.0 0.4 GO:0071277 cellular response to calcium ion(GO:0071277)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0005642 annulate lamellae(GO:0005642)
0.1 0.2 GO:0034750 Scrib-APC-beta-catenin complex(GO:0034750)
0.1 0.4 GO:0005915 zonula adherens(GO:0005915)
0.1 0.2 GO:1990761 growth cone lamellipodium(GO:1990761)
0.1 0.2 GO:0097149 centralspindlin complex(GO:0097149)
0.1 0.7 GO:0005640 nuclear outer membrane(GO:0005640)
0.0 0.3 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890)
0.0 0.3 GO:0030991 intraciliary transport particle A(GO:0030991)
0.0 0.1 GO:0002139 stereocilia coupling link(GO:0002139)
0.0 0.1 GO:0017133 mitochondrial electron transfer flavoprotein complex(GO:0017133) electron transfer flavoprotein complex(GO:0045251)
0.0 0.3 GO:0031462 Cul2-RING ubiquitin ligase complex(GO:0031462)
0.0 0.2 GO:0044294 dendritic growth cone(GO:0044294)
0.0 0.1 GO:0044326 dendritic spine neck(GO:0044326)
0.0 0.1 GO:0016222 procollagen-proline 4-dioxygenase complex(GO:0016222)
0.0 0.2 GO:0016600 flotillin complex(GO:0016600)
0.0 0.1 GO:0042406 extrinsic component of endoplasmic reticulum membrane(GO:0042406)
0.0 0.2 GO:0005577 fibrinogen complex(GO:0005577)
0.0 0.1 GO:0031258 lamellipodium membrane(GO:0031258)
0.0 0.2 GO:0005832 chaperonin-containing T-complex(GO:0005832)
0.0 0.1 GO:0016342 catenin complex(GO:0016342)
0.0 0.1 GO:0042583 chromaffin granule(GO:0042583)
0.0 0.1 GO:1990075 periciliary membrane compartment(GO:1990075)
0.0 0.2 GO:0046581 intercellular canaliculus(GO:0046581)
0.0 0.1 GO:0033256 I-kappaB/NF-kappaB complex(GO:0033256)
0.0 0.1 GO:0005785 signal recognition particle receptor complex(GO:0005785)
0.0 0.1 GO:0034363 intermediate-density lipoprotein particle(GO:0034363)
0.0 0.2 GO:0030061 mitochondrial crista(GO:0030061)
0.0 0.1 GO:0071986 Ragulator complex(GO:0071986)
0.0 0.1 GO:0000235 astral microtubule(GO:0000235)
0.0 0.2 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.0 0.1 GO:0000120 RNA polymerase I transcription factor complex(GO:0000120)
0.0 0.1 GO:0000124 SAGA complex(GO:0000124)
0.0 0.2 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.0 0.3 GO:0097440 apical dendrite(GO:0097440)
0.0 0.2 GO:0032279 asymmetric synapse(GO:0032279)
0.0 0.0 GO:0097454 Schwann cell microvillus(GO:0097454)
0.0 0.1 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
0.0 0.1 GO:0042765 GPI-anchor transamidase complex(GO:0042765)
0.0 0.0 GO:0042719 mitochondrial intermembrane space protein transporter complex(GO:0042719)
0.0 0.1 GO:0031232 extrinsic component of external side of plasma membrane(GO:0031232)
0.0 0.1 GO:0031415 NatA complex(GO:0031415)
0.0 0.0 GO:0000802 transverse filament(GO:0000802)
0.0 0.0 GO:0000835 ER ubiquitin ligase complex(GO:0000835) Hrd1p ubiquitin ligase complex(GO:0000836)
0.0 0.1 GO:0030062 mitochondrial tricarboxylic acid cycle enzyme complex(GO:0030062)
0.0 0.0 GO:0009279 cell outer membrane(GO:0009279) cell envelope(GO:0030313) external encapsulating structure part(GO:0044462)
0.0 0.0 GO:0005594 collagen type IX trimer(GO:0005594)
0.0 0.1 GO:0005827 polar microtubule(GO:0005827)
0.0 0.1 GO:0008278 cohesin complex(GO:0008278)
0.0 0.0 GO:0030015 CCR4-NOT core complex(GO:0030015)
0.0 0.2 GO:0005779 integral component of peroxisomal membrane(GO:0005779)
0.0 0.0 GO:0038037 G-protein coupled receptor dimeric complex(GO:0038037) G-protein coupled receptor complex(GO:0097648)
0.0 0.1 GO:0070775 H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776)
0.0 0.1 GO:0035749 myelin sheath adaxonal region(GO:0035749)
0.0 0.5 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 0.1 GO:0000815 ESCRT III complex(GO:0000815)
0.0 0.0 GO:0016942 insulin-like growth factor binding protein complex(GO:0016942) growth factor complex(GO:0036454) insulin-like growth factor ternary complex(GO:0042567)
0.0 0.0 GO:0090533 cation-transporting ATPase complex(GO:0090533)
0.0 0.1 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.0 0.0 GO:0000938 GARP complex(GO:0000938)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0017153 sodium:dicarboxylate symporter activity(GO:0017153)
0.1 0.3 GO:0030899 calcium-dependent ATPase activity(GO:0030899)
0.1 0.2 GO:1990188 euchromatin binding(GO:1990188)
0.1 1.5 GO:0017075 syntaxin-1 binding(GO:0017075)
0.1 0.2 GO:0042895 antibiotic transporter activity(GO:0042895)
0.1 0.1 GO:0008427 calcium-dependent protein kinase inhibitor activity(GO:0008427)
0.1 0.2 GO:0008525 phosphatidylcholine transporter activity(GO:0008525)
0.1 0.2 GO:0046573 lactonohydrolase activity(GO:0046573) acyl-L-homoserine-lactone lactonohydrolase activity(GO:0102007)
0.1 0.2 GO:0008503 benzodiazepine receptor activity(GO:0008503)
0.0 0.3 GO:0043495 protein anchor(GO:0043495)
0.0 0.1 GO:0051765 inositol tetrakisphosphate kinase activity(GO:0051765)
0.0 0.2 GO:0051425 PTB domain binding(GO:0051425)
0.0 0.3 GO:0070097 delta-catenin binding(GO:0070097)
0.0 0.6 GO:0001671 ATPase activator activity(GO:0001671)
0.0 0.1 GO:0042392 sphingosine-1-phosphate phosphatase activity(GO:0042392)
0.0 0.1 GO:0004416 hydroxyacylglutathione hydrolase activity(GO:0004416)
0.0 0.2 GO:0070052 collagen V binding(GO:0070052)
0.0 0.9 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.0 0.3 GO:0016907 G-protein coupled acetylcholine receptor activity(GO:0016907)
0.0 0.2 GO:0001515 opioid peptide activity(GO:0001515)
0.0 0.1 GO:0016715 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen(GO:0016715)
0.0 0.2 GO:0035473 lipase binding(GO:0035473)
0.0 0.1 GO:0004735 pyrroline-5-carboxylate reductase activity(GO:0004735)
0.0 0.1 GO:0031686 A1 adenosine receptor binding(GO:0031686)
0.0 0.2 GO:0022820 potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820)
0.0 0.1 GO:0047751 3-oxo-5-alpha-steroid 4-dehydrogenase activity(GO:0003865) cholestenone 5-alpha-reductase activity(GO:0047751)
0.0 0.1 GO:0004345 glucose-6-phosphate dehydrogenase activity(GO:0004345)
0.0 0.1 GO:1990430 extracellular matrix protein binding(GO:1990430)
0.0 0.1 GO:0031893 vasopressin receptor binding(GO:0031893)
0.0 0.1 GO:0004515 nicotinamide-nucleotide adenylyltransferase activity(GO:0000309) nicotinate-nucleotide adenylyltransferase activity(GO:0004515)
0.0 0.2 GO:0005113 patched binding(GO:0005113)
0.0 0.1 GO:0008515 sucrose:proton symporter activity(GO:0008506) sucrose transmembrane transporter activity(GO:0008515) disaccharide transmembrane transporter activity(GO:0015154) oligosaccharide transmembrane transporter activity(GO:0015157)
0.0 0.1 GO:0015093 ferrous iron transmembrane transporter activity(GO:0015093)
0.0 0.2 GO:0043008 ATP-dependent protein binding(GO:0043008)
0.0 0.1 GO:0070137 ubiquitin-like protein-specific endopeptidase activity(GO:0070137) SUMO-specific endopeptidase activity(GO:0070139)
0.0 0.1 GO:0031685 adenosine receptor binding(GO:0031685)
0.0 0.1 GO:0004886 9-cis retinoic acid receptor activity(GO:0004886)
0.0 0.3 GO:0016662 oxidoreductase activity, acting on other nitrogenous compounds as donors, cytochrome as acceptor(GO:0016662)
0.0 0.1 GO:0031750 D3 dopamine receptor binding(GO:0031750)
0.0 0.1 GO:0051959 dynein light intermediate chain binding(GO:0051959)
0.0 0.6 GO:0001540 beta-amyloid binding(GO:0001540)
0.0 0.1 GO:0030368 interleukin-17 receptor activity(GO:0030368)
0.0 0.1 GO:0102344 3-hydroxy-behenoyl-CoA dehydratase activity(GO:0102344) 3-hydroxy-lignoceroyl-CoA dehydratase activity(GO:0102345)
0.0 0.1 GO:0004301 epoxide hydrolase activity(GO:0004301)
0.0 0.1 GO:0005347 ATP transmembrane transporter activity(GO:0005347)
0.0 0.1 GO:0004656 procollagen-proline 4-dioxygenase activity(GO:0004656)
0.0 0.2 GO:0034450 ubiquitin-ubiquitin ligase activity(GO:0034450)
0.0 0.1 GO:0016721 superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721)
0.0 0.1 GO:0035514 DNA demethylase activity(GO:0035514)
0.0 0.1 GO:2001070 starch binding(GO:2001070)
0.0 0.1 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.0 0.1 GO:0051377 mannose-ethanolamine phosphotransferase activity(GO:0051377)
0.0 0.3 GO:0016594 glycine binding(GO:0016594)
0.0 0.2 GO:0004438 phosphatidylinositol-3-phosphatase activity(GO:0004438)
0.0 0.1 GO:1901612 cardiolipin binding(GO:1901612)
0.0 0.1 GO:0017169 CDP-alcohol phosphatidyltransferase activity(GO:0017169)
0.0 0.1 GO:0019788 NEDD8 transferase activity(GO:0019788)
0.0 0.1 GO:0003986 acetyl-CoA hydrolase activity(GO:0003986)
0.0 0.3 GO:0008143 poly(A) binding(GO:0008143)
0.0 0.2 GO:1990939 ATP-dependent microtubule motor activity(GO:1990939)
0.0 0.1 GO:0030229 very-low-density lipoprotein particle receptor activity(GO:0030229)
0.0 0.1 GO:0052851 cupric reductase activity(GO:0008823) ferric-chelate reductase (NADPH) activity(GO:0052851)
0.0 0.0 GO:0016802 adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.0 0.1 GO:0004994 somatostatin receptor activity(GO:0004994)
0.0 0.0 GO:1990050 phosphatidic acid transporter activity(GO:1990050)
0.0 0.1 GO:0015375 glycine:sodium symporter activity(GO:0015375)
0.0 0.1 GO:0098599 palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.0 1.2 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.0 0.1 GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives(GO:0016857)
0.0 0.1 GO:0033592 RNA strand annealing activity(GO:0033592)
0.0 0.1 GO:0003997 acyl-CoA oxidase activity(GO:0003997)
0.0 0.1 GO:0005131 growth hormone receptor binding(GO:0005131)
0.0 0.2 GO:0044183 protein binding involved in protein folding(GO:0044183)
0.0 0.0 GO:0004719 protein-L-isoaspartate (D-aspartate) O-methyltransferase activity(GO:0004719)
0.0 0.0 GO:0015141 succinate transmembrane transporter activity(GO:0015141)
0.0 0.4 GO:0052677 C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity(GO:0000252) mevaldate reductase activity(GO:0004495) gluconate dehydrogenase activity(GO:0008875) epoxide dehydrogenase activity(GO:0018451) 5-exo-hydroxycamphor dehydrogenase activity(GO:0018452) 2-hydroxytetrahydrofuran dehydrogenase activity(GO:0018453) acetoin dehydrogenase activity(GO:0019152) phenylcoumaran benzylic ether reductase activity(GO:0032442) D-xylose:NADP reductase activity(GO:0032866) L-arabinose:NADP reductase activity(GO:0032867) D-arabinitol dehydrogenase, D-ribulose forming (NADP+) activity(GO:0033709) (R)-(-)-1,2,3,4-tetrahydronaphthol dehydrogenase activity(GO:0034831) 3-hydroxymenthone dehydrogenase activity(GO:0034840) very long-chain-3-hydroxyacyl-CoA dehydrogenase activity(GO:0035380) (R)-2-hydroxyisocaproate dehydrogenase activity(GO:0043713) L-arabinose 1-dehydrogenase (NADP+) activity(GO:0044103) L-xylulose reductase (NAD+) activity(GO:0044105) 3-ketoglucose-reductase activity(GO:0048258) D-arabinitol dehydrogenase, D-xylulose forming (NADP+) activity(GO:0052677)
0.0 0.1 GO:0031781 melanocortin receptor binding(GO:0031779) type 3 melanocortin receptor binding(GO:0031781) type 4 melanocortin receptor binding(GO:0031782)
0.0 0.1 GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
0.0 0.4 GO:0019706 protein-cysteine S-palmitoyltransferase activity(GO:0019706)
0.0 0.1 GO:0070061 fructose binding(GO:0070061)
0.0 0.1 GO:0036033 mediator complex binding(GO:0036033)
0.0 0.0 GO:0030911 TPR domain binding(GO:0030911)
0.0 0.1 GO:0005222 intracellular cAMP activated cation channel activity(GO:0005222)
0.0 0.0 GO:0035650 AP-1 adaptor complex binding(GO:0035650)
0.0 0.1 GO:0005072 transforming growth factor beta receptor, cytoplasmic mediator activity(GO:0005072)
0.0 0.1 GO:0004908 interleukin-1 receptor activity(GO:0004908)
0.0 0.1 GO:0010314 phosphatidylinositol-5-phosphate binding(GO:0010314)
0.0 0.2 GO:0035497 cAMP response element binding(GO:0035497)
0.0 0.1 GO:0019808 polyamine binding(GO:0019808)
0.0 0.1 GO:0030898 actin-dependent ATPase activity(GO:0030898)
0.0 0.1 GO:0008568 microtubule-severing ATPase activity(GO:0008568)
0.0 0.1 GO:0030235 nitric-oxide synthase regulator activity(GO:0030235)
0.0 0.1 GO:0044020 histone methyltransferase activity (H4-R3 specific)(GO:0044020)
0.0 0.1 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
0.0 0.0 GO:0035663 Toll-like receptor 2 binding(GO:0035663)
0.0 0.2 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.0 0.1 GO:0005005 transmembrane-ephrin receptor activity(GO:0005005)
0.0 0.1 GO:0046975 histone methyltransferase activity (H3-K36 specific)(GO:0046975)
0.0 0.0 GO:0004687 myosin light chain kinase activity(GO:0004687)
0.0 0.1 GO:0001163 RNA polymerase I regulatory region sequence-specific DNA binding(GO:0001163) RNA polymerase I CORE element sequence-specific DNA binding(GO:0001164)
0.0 0.1 GO:0000182 rDNA binding(GO:0000182)
0.0 0.1 GO:0016176 superoxide-generating NADPH oxidase activator activity(GO:0016176)
0.0 0.0 GO:0035515 oxidative RNA demethylase activity(GO:0035515)
0.0 0.0 GO:0003941 L-serine ammonia-lyase activity(GO:0003941)
0.0 0.1 GO:0032027 myosin light chain binding(GO:0032027)
0.0 0.0 GO:0004965 G-protein coupled GABA receptor activity(GO:0004965)
0.0 0.1 GO:0004468 lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468)
0.0 0.0 GO:0072345 NAADP-sensitive calcium-release channel activity(GO:0072345)
0.0 0.0 GO:0008142 oxysterol binding(GO:0008142)
0.0 0.0 GO:0047045 testosterone 17-beta-dehydrogenase (NADP+) activity(GO:0047045)
0.0 0.0 GO:0004939 beta-adrenergic receptor activity(GO:0004939)
0.0 0.2 GO:0017049 GTP-Rho binding(GO:0017049)
0.0 0.0 GO:0016971 flavin-linked sulfhydryl oxidase activity(GO:0016971)
0.0 0.0 GO:0016018 cyclosporin A binding(GO:0016018)
0.0 0.1 GO:0045545 syndecan binding(GO:0045545)
0.0 0.1 GO:0051787 misfolded protein binding(GO:0051787)
0.0 0.0 GO:0004849 uridine kinase activity(GO:0004849)
0.0 0.0 GO:0004351 glutamate decarboxylase activity(GO:0004351)
0.0 0.0 GO:0008808 cardiolipin synthase activity(GO:0008808) phosphatidyltransferase activity(GO:0030572)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 SIG PIP3 SIGNALING IN B LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes
0.0 1.8 PID IFNG PATHWAY IFN-gamma pathway
0.0 0.3 PID VEGF VEGFR PATHWAY VEGF and VEGFR signaling network
0.0 0.1 PID WNT CANONICAL PATHWAY Canonical Wnt signaling pathway
0.0 0.5 PID ARF6 PATHWAY Arf6 signaling events
0.0 0.3 PID SMAD2 3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.0 0.2 PID TCPTP PATHWAY Signaling events mediated by TCPTP
0.0 0.1 PID S1P S1P3 PATHWAY S1P3 pathway
0.0 0.3 PID GLYPICAN 1PATHWAY Glypican 1 network
0.0 0.6 PID ECADHERIN STABILIZATION PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.0 0.0 PID ERBB NETWORK PATHWAY ErbB receptor signaling network
0.0 0.1 ST PAC1 RECEPTOR PATHWAY PAC1 Receptor Pathway
0.0 0.1 PID ARF6 DOWNSTREAM PATHWAY Arf6 downstream pathway
0.0 0.4 ST T CELL SIGNAL TRANSDUCTION T Cell Signal Transduction
0.0 0.2 PID EPHB FWD PATHWAY EPHB forward signaling
0.0 0.3 PID SHP2 PATHWAY SHP2 signaling
0.0 0.0 ST PHOSPHOINOSITIDE 3 KINASE PATHWAY PI3K Pathway
0.0 0.2 SA B CELL RECEPTOR COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.7 REACTOME ROLE OF DCC IN REGULATING APOPTOSIS Genes involved in Role of DCC in regulating apoptosis
0.0 0.4 REACTOME IRAK1 RECRUITS IKK COMPLEX Genes involved in IRAK1 recruits IKK complex
0.0 0.1 REACTOME RAP1 SIGNALLING Genes involved in Rap1 signalling
0.0 0.3 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.0 0.3 REACTOME VEGF LIGAND RECEPTOR INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.0 0.3 REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
0.0 0.3 REACTOME RETROGRADE NEUROTROPHIN SIGNALLING Genes involved in Retrograde neurotrophin signalling
0.0 0.2 REACTOME THE NLRP3 INFLAMMASOME Genes involved in The NLRP3 inflammasome
0.0 0.1 REACTOME IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION Genes involved in IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
0.0 0.3 REACTOME PLATELET CALCIUM HOMEOSTASIS Genes involved in Platelet calcium homeostasis
0.0 0.3 REACTOME BASIGIN INTERACTIONS Genes involved in Basigin interactions
0.0 0.2 REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.0 0.2 REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.0 0.4 REACTOME NEP NS2 INTERACTS WITH THE CELLULAR EXPORT MACHINERY Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery
0.0 0.0 REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE Genes involved in mRNA Decay by 3' to 5' Exoribonuclease
0.0 0.3 REACTOME SULFUR AMINO ACID METABOLISM Genes involved in Sulfur amino acid metabolism
0.0 0.3 REACTOME EFFECTS OF PIP2 HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.0 0.0 REACTOME PI3K EVENTS IN ERBB2 SIGNALING Genes involved in PI3K events in ERBB2 signaling
0.0 0.0 REACTOME PLATELET HOMEOSTASIS Genes involved in Platelet homeostasis
0.0 0.1 REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24 HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol
0.0 0.0 REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Norepinephrine Neurotransmitter Release Cycle
0.0 0.2 REACTOME SIGNALING BY FGFR1 FUSION MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
0.0 0.1 REACTOME RECYCLING OF BILE ACIDS AND SALTS Genes involved in Recycling of bile acids and salts
0.0 0.1 REACTOME RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES Genes involved in Recruitment of NuMA to mitotic centrosomes
0.0 0.0 REACTOME SIGNALING BY CONSTITUTIVELY ACTIVE EGFR Genes involved in Signaling by constitutively active EGFR
0.0 0.0 REACTOME NFKB IS ACTIVATED AND SIGNALS SURVIVAL Genes involved in NF-kB is activated and signals survival
0.0 0.0 REACTOME CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
0.0 0.2 REACTOME KINESINS Genes involved in Kinesins
0.0 0.1 REACTOME IL 6 SIGNALING Genes involved in Interleukin-6 signaling
0.0 0.2 REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC Genes involved in Formation of tubulin folding intermediates by CCT/TriC