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ENCSR904DTN: DNase-seq of mouse liver in constant darkness

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for Zkscan3

Z-value: 3.04

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Transcription factors associated with Zkscan3

Gene Symbol	Gene ID	Gene Info
Zkscan3 Ensembl NCBI MGI UniProt	ENSMUSG00000021327.12	Zkscan3

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

Gene	Promoter	Distance	Association probability	Pearson corr. coef.	P-value	Plot
Zkscan3	chr13_21402344_21402506	245	0.807795	0.75	8.8e-02	Click!
Zkscan3	chr13_21402673_21402832	3	0.938289	0.60	2.1e-01	Click!
Zkscan3	chr13_21401689_21401902	875	0.336824	0.58	2.2e-01	Click!
Zkscan3	chr13_21402012_21402170	579	0.506873	0.52	2.9e-01	Click!
Zkscan3	chr13_21401499_21401673	1084	0.264744	-0.35	5.0e-01	Click!

Activity of the Zkscan3 motif across conditions

Conditions sorted by the z-value of the Zkscan3 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr9_65334133_65334359	4.38	Gm39363	predicted gene, 39363	1726	0.18
chr8_35387028_35387898	2.40	Ppp1r3b	protein phosphatase 1, regulatory subunit 3B	10803	0.16
chr13_93628549_93628834	2.21	Gm15622	predicted gene 15622	3309	0.2
chr16_97900645_97900797	1.94	C2cd2	C2 calcium-dependent domain containing 2	8440	0.18
chr5_112299397_112299785	1.79	Tpst2	protein-tyrosine sulfotransferase 2	4305	0.13
chr7_98352590_98353259	1.71	Tsku	tsukushi, small leucine rich proteoglycan	7155	0.18
chr6_122819078_122819314	1.52	Foxj2	forkhead box J2	718	0.44
chr9_61826654_61826867	1.52	Gm19208	predicted gene, 19208	24944	0.2
chr11_4906060_4906238	1.50	Thoc5	THO complex 5	3937	0.15
chr3_98226583_98226734	1.40	Reg4	regenerating islet-derived family, member 4	4502	0.17
chr6_144781221_144781581	1.40	Sox5	SRY (sex determining region Y)-box 5	518	0.79
chr14_21171384_21171535	1.30	Adk	adenosine kinase	95307	0.07
chr19_3650199_3650464	1.28	Lrp5	low density lipoprotein receptor-related protein 5	34539	0.1
chr14_76556939_76557219	1.27	Serp2	stress-associated endoplasmic reticulum protein family member 2	190	0.95
chr17_28436590_28436749	1.26	Fkbp5	FK506 binding protein 5	4341	0.12
chr19_61048296_61048486	1.24	Gm22520	predicted gene, 22520	34846	0.14
chr7_125578941_125579144	1.21	Gm44876	predicted gene 44876	6925	0.16
chr8_120369815_120369966	1.21	Gm22715	predicted gene, 22715	73659	0.09
chr17_33932399_33932565	1.20	Rgl2	ral guanine nucleotide dissociation stimulator-like 2	351	0.58
chr8_41026178_41026329	1.17	Mtus1	mitochondrial tumor suppressor 1	3351	0.19
chr7_98849207_98849358	1.14	Wnt11	wingless-type MMTV integration site family, member 11	1476	0.34
chr10_95317812_95318192	1.13	Gm48882	predicted gene, 48882	245	0.88
chr2_153586432_153586583	1.13	Commd7	COMM domain containing 7	46224	0.11
chr1_74061177_74061331	1.13	Tns1	tensin 1	24097	0.17
chr6_145764862_145765013	1.09	Rassf8	Ras association (RalGDS/AF-6) domain family (N-terminal) member 8	14366	0.19
chr14_100324093_100324244	1.07	Gm41231	predicted gene, 41231	38003	0.15
chr15_36472644_36473037	1.06	Ankrd46	ankyrin repeat domain 46	23875	0.13
chr10_80340392_80340718	1.02	Adamtsl5	ADAMTS-like 5	470	0.56
chr8_124201642_124201985	1.00	Galnt2	polypeptide N-acetylgalactosaminyltransferase 2	29578	0.15
chr4_140858134_140858561	1.00	Padi1	peptidyl arginine deiminase, type I	12569	0.12
chr10_122986042_122986255	1.00	D630033A02Rik	RIKEN cDNA D630033A02 gene	317	0.58
chr18_73844340_73844698	0.99	Mro	maestro	14866	0.2
chr17_46110701_46110892	0.99	Mrps18a	mitochondrial ribosomal protein S18A	190	0.91
chr5_126543958_126544274	0.99	Gm24839	predicted gene, 24839	30135	0.19
chr9_115476457_115476622	0.99	Gm5921	predicted gene 5921	37958	0.14
chr6_42352219_42352377	0.98	Zyx	zyxin	1180	0.24
chr18_70568874_70569217	0.98	Mbd2	methyl-CpG binding domain protein 2	711	0.68
chr2_167326193_167326424	0.98	B4galt5	UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 5	12408	0.18
chr2_126570201_126570813	0.98	Slc27a2	solute carrier family 27 (fatty acid transporter), member 2	5747	0.2
chr17_30619245_30619423	0.97	Dnah8	dynein, axonemal, heavy chain 8	5020	0.12
chr7_127214965_127215278	0.97	Septin1	septin 1	4	0.92
chr5_24586259_24586557	0.97	Chpf2	chondroitin polymerizing factor 2	333	0.76
chr9_118925675_118926262	0.97	Gm2415	predicted gene 2415	290	0.62
chr13_19395072_19395660	0.96	Gm42683	predicted gene 42683	87	0.82
chr9_32004053_32004204	0.96	Gm47465	predicted gene, 47465	1332	0.4
chr8_124897995_124898160	0.96	Sprtn	SprT-like N-terminal domain	191	0.68
chr4_149978768_149979375	0.95	H6pd	hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)	22194	0.13
chr13_28421437_28421636	0.94	Gm40841	predicted gene, 40841	1470	0.49
chr16_33947299_33947485	0.94	Itgb5	integrin beta 5	868	0.56
chr4_133049992_133050178	0.92	Ahdc1	AT hook, DNA binding motif, containing 1	10592	0.19
chr15_79141450_79141641	0.92	Polr2f	polymerase (RNA) II (DNA directed) polypeptide F	179	0.62
chr4_118132718_118132924	0.91	St3gal3	ST3 beta-galactoside alpha-2,3-sialyltransferase 3	2061	0.28
chr3_103789902_103790723	0.90	Hipk1	homeodomain interacting protein kinase 1	763	0.4
chr3_101519636_101519818	0.90	Atp1a1	ATPase, Na+/K+ transporting, alpha 1 polypeptide	57833	0.1
chr9_70940473_70940653	0.88	Lipc	lipase, hepatic	5755	0.22
chr13_113864739_113864979	0.88	Arl15	ADP-ribosylation factor-like 15	70237	0.09
chr8_12677440_12677591	0.88	4931415C17Rik	RIKEN cDNA 4931415C17 gene	5088	0.15
chr13_60644455_60644612	0.87	Gm48583	predicted gene, 48583	2743	0.25
chr15_34469803_34469957	0.86	Gm49188	predicted gene, 49188	11827	0.1
chr12_100199636_100199926	0.86	Calm1	calmodulin 1	252	0.89
chr2_75603496_75603684	0.84	Gm13655	predicted gene 13655	29792	0.14
chr11_116104363_116104575	0.82	Trim47	tripartite motif-containing 47	2614	0.14
chr2_30268240_30268600	0.82	Phyhd1	phytanoyl-CoA dioxygenase domain containing 1	1557	0.21
chr10_81419362_81419546	0.81	Mir1191b	microRNA 1191b	3157	0.08
chr19_7240751_7240928	0.80	Naa40	N(alpha)-acetyltransferase 40, NatD catalytic subunit	195	0.89
chr5_124353375_124353533	0.80	Cdk2ap1	CDK2 (cyclin-dependent kinase 2)-associated protein 1	1217	0.33
chr5_89462978_89463338	0.79	Gc	vitamin D binding protein	5260	0.24
chr2_32682708_32682915	0.78	Fpgs	folylpolyglutamyl synthetase	2193	0.12
chr8_11262573_11262724	0.77	Col4a1	collagen, type IV, alpha 1	17008	0.16
chr19_5851015_5851290	0.77	Frmd8os	FERM domain containing 8, opposite strand	2644	0.11
chr16_17235100_17235306	0.77	Hic2	hypermethylated in cancer 2	1539	0.2
chr9_96727975_96728455	0.76	Zbtb38	zinc finger and BTB domain containing 38	821	0.58
chr18_20670501_20671004	0.76	Ttr	transthyretin	5472	0.18
chr3_137863947_137864380	0.76	Gm43403	predicted gene 43403	20	0.81
chr19_44400900_44401269	0.76	Scd1	stearoyl-Coenzyme A desaturase 1	5606	0.16
chr7_16597600_16597898	0.75	Gm29443	predicted gene 29443	16075	0.09
chr9_90109465_90109757	0.74	Morf4l1	mortality factor 4 like 1	4678	0.17
chr16_38433421_38433613	0.74	Pla1a	phospholipase A1 member A	372	0.8
chr11_60786856_60787068	0.73	Shmt1	serine hydroxymethyltransferase 1 (soluble)	6211	0.09
chr19_46908820_46909200	0.73	Nt5c2	5'-nucleotidase, cytosolic II	565	0.74
chr13_54076591_54076742	0.71	Sfxn1	sideroflexin 1	4797	0.21
chr2_30436208_30436447	0.70	Ptpa	protein phosphatase 2 protein activator	1902	0.22
chr3_146403874_146404213	0.70	Ssx2ip	synovial sarcoma, X 2 interacting protein	599	0.64
chr7_98177945_98178149	0.69	Capn5	calpain 5	227	0.83
chr11_75422344_75422535	0.69	Serpinf1	serine (or cysteine) peptidase inhibitor, clade F, member 1	113	0.88
chr2_25708935_25709097	0.68	A230005M16Rik	RIKEN cDNA A230005M16 gene	700	0.42
chr17_47873312_47873495	0.68	Foxp4	forkhead box P4	5550	0.14
chr6_42251736_42251903	0.68	Gstk1	glutathione S-transferase kappa 1	5796	0.11
chr2_173156797_173157495	0.68	Pck1	phosphoenolpyruvate carboxykinase 1, cytosolic	4064	0.2
chr9_48738331_48738489	0.67	Zbtb16	zinc finger and BTB domain containing 16	97535	0.07
chr4_62779675_62780043	0.67	Gm24117	predicted gene, 24117	32569	0.15
chr2_32421538_32422351	0.67	Slc25a25	solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 25	36	0.95
chr16_84805927_84806078	0.66	Jam2	junction adhesion molecule 2	3405	0.17
chr14_66129671_66129842	0.66	Ephx2	epoxide hydrolase 2, cytoplasmic	5256	0.17
chr4_95625117_95625268	0.65	Fggy	FGGY carbohydrate kinase domain containing	1636	0.46
chr9_122049922_122050484	0.65	Gm39465	predicted gene, 39465	1155	0.34
chr9_20740746_20740928	0.65	Olfm2	olfactomedin 2	5512	0.16
chr2_118844371_118844522	0.65	Gm14091	predicted gene 14091	10324	0.12
chr6_113644583_113645202	0.65	Gm43964	predicted gene, 43964	3371	0.09
chr11_102267338_102267489	0.65	Asb16	ankyrin repeat and SOCS box-containing 16	1330	0.26
chr2_94067079_94067259	0.64	Hsd17b12	hydroxysteroid (17-beta) dehydrogenase 12	405	0.86
chr19_20450928_20451527	0.64	C730002L08Rik	RIKEN cDNA C730002L08 gene	26445	0.16
chr10_81233301_81233523	0.64	Zfr2	zinc finger RNA binding protein 2	225	0.8
chr4_116006006_116006178	0.64	Faah	fatty acid amide hydrolase	6024	0.15
chr11_75211079_75211230	0.63	Rtn4rl1	reticulon 4 receptor-like 1	17371	0.1
chr10_24831746_24832070	0.63	Enpp3	ectonucleotide pyrophosphatase/phosphodiesterase 3	102	0.97
chr11_107025954_107026367	0.63	1810010H24Rik	RIKEN cDNA 1810010H24 gene	479	0.74
chr2_167328678_167328847	0.62	B4galt5	UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 5	14862	0.18
chr15_99032417_99032770	0.62	Tuba1c	tubulin, alpha 1C	2272	0.15
chr15_76745135_76745286	0.62	Arhgap39	Rho GTPase activating protein 39	19607	0.08
chr15_31264328_31264561	0.62	Dap	death-associated protein	3892	0.19
chr16_93823192_93823406	0.61	Morc3	microrchidia 3	8822	0.13
chr10_33950641_33951001	0.60	Zup1	zinc finger containing ubiquitin peptidase 1	374	0.76
chr9_53301822_53302322	0.60	Exph5	exophilin 5	402	0.86
chr9_70234355_70234506	0.60	Myo1e	myosin IE	27062	0.19
chr19_61048615_61048813	0.59	Gm22520	predicted gene, 22520	35169	0.14
chr17_45834393_45834544	0.59	Gm35692	predicted gene, 35692	12145	0.16
chr18_75601004_75601199	0.59	Ctif	CBP80/20-dependent translation initiation factor	36172	0.19
chr19_43510545_43510713	0.58	Got1	glutamic-oxaloacetic transaminase 1, soluble	5236	0.13
chrX_75874057_75874225	0.58	Pls3	plastin 3 (T-isoform)	433	0.81
chr6_21828351_21828787	0.58	Tspan12	tetraspanin 12	23259	0.17
chr14_70198497_70198662	0.57	Sorbs3	sorbin and SH3 domain containing 3	6044	0.12
chr16_37635141_37635534	0.57	Hgd	homogentisate 1, 2-dioxygenase	13488	0.15
chr5_66148784_66148935	0.57	Rbm47	RNA binding motif protein 47	2097	0.18
chr1_88286437_88286600	0.57	Trpm8	transient receptor potential cation channel, subfamily M, member 8	8857	0.11
chr8_124567905_124568437	0.56	Agt	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	1535	0.36
chr5_52975314_52975474	0.56	Gm30301	predicted gene, 30301	6643	0.16
chr15_65846454_65846635	0.56	Efr3a	EFR3 homolog A	4577	0.22
chr14_45220729_45220892	0.55	Txndc16	thioredoxin domain containing 16	482	0.52
chr10_70097931_70098284	0.55	Ccdc6	coiled-coil domain containing 6	986	0.66
chr8_120366684_120367118	0.55	Gm22715	predicted gene, 22715	76648	0.08
chr9_62342926_62343110	0.55	Anp32a	acidic (leucine-rich) nuclear phosphoprotein 32 family, member A	554	0.78
chr2_31479577_31479870	0.54	Ass1	argininosuccinate synthetase 1	9516	0.19
chr9_62367194_62367386	0.54	Anp32a	acidic (leucine-rich) nuclear phosphoprotein 32 family, member A	346	0.89
chr4_132628872_132629046	0.53	Eya3	EYA transcriptional coactivator and phosphatase 3	10028	0.15
chr15_79733610_79733958	0.53	Sun2	Sad1 and UNC84 domain containing 2	2167	0.15
chr16_13201906_13202058	0.53	Mrtfb	myocardin related transcription factor B	54499	0.14
chr16_72830483_72830654	0.53	Robo1	roundabout guidance receptor 1	145781	0.05
chr7_79831481_79831780	0.52	Gm44974	predicted gene 44974	241	0.87
chr16_85901352_85901509	0.52	Adamts5	a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 5 (aggrecanase-2)	398	0.9
chr2_163301297_163301733	0.52	Tox2	TOX high mobility group box family member 2	18863	0.19
chr10_61143381_61143586	0.52	Sgpl1	sphingosine phosphate lyase 1	3415	0.19
chr16_45975826_45976145	0.52	Phldb2	pleckstrin homology like domain, family B, member 2	22387	0.14
chr5_73337973_73338415	0.52	Ociad2	OCIA domain containing 2	364	0.79
chr19_6855220_6855477	0.52	Ccdc88b	coiled-coil domain containing 88B	110	0.93
chr1_86879397_86879607	0.51	Gm37541	predicted gene, 37541	5152	0.12
chr16_91833643_91834213	0.50	Itsn1	intersectin 1 (SH3 domain protein 1A)	5771	0.19
chr6_91655124_91655309	0.50	Gm45217	predicted gene 45217	24007	0.11
chr8_33871610_33871761	0.50	Gm26978	predicted gene, 26978	14062	0.16
chr1_158142001_158142160	0.50	Brinp2	bone morphogenic protein/retinoic acid inducible neural-specific 2	154384	0.04
chr9_106756626_106756783	0.50	Rad54l2	RAD54 like 2 (S. cerevisiae)	32472	0.12
chr8_119912901_119913087	0.49	Usp10	ubiquitin specific peptidase 10	2137	0.24
chr7_79781946_79782169	0.49	Gm44705	predicted gene 44705	8568	0.1
chr10_81422057_81422238	0.49	Nfic	nuclear factor I/C	4967	0.07
chr13_99099705_99099869	0.49	Gm807	predicted gene 807	919	0.55
chr4_43421375_43421673	0.49	Rusc2	RUN and SH3 domain containing 2	968	0.4
chr9_44387040_44387229	0.49	Hyou1	hypoxia up-regulated 1	3527	0.07
chr4_8754704_8754856	0.49	Chd7	chromodomain helicase DNA binding protein 7	3342	0.36
chr2_180906861_180907031	0.48	Gm27032	predicted gene, 27032	12841	0.09
chr17_71255942_71256093	0.48	Emilin2	elastin microfibril interfacer 2	329	0.86
chr13_37874544_37874704	0.48	Rreb1	ras responsive element binding protein 1	13810	0.2
chr19_6924075_6924226	0.48	Catsperz	cation channel sperm associated auxiliary subunit zeta	719	0.37
chr8_83589428_83589579	0.48	Gm45823	predicted gene 45823	3978	0.11
chrX_140525251_140525408	0.48	Tsc22d3	TSC22 domain family, member 3	17339	0.19
chr8_35207158_35207309	0.47	Gm34474	predicted gene, 34474	11405	0.14
chr10_111364892_111365156	0.47	Gm40761	predicted gene, 40761	27900	0.17
chr9_14439768_14439948	0.47	Gm47318	predicted gene, 47318	4447	0.13
chr10_75794436_75794892	0.47	Gstt1	glutathione S-transferase, theta 1	2905	0.13
chr8_81378490_81378647	0.46	Inpp4b	inositol polyphosphate-4-phosphatase, type II	36006	0.19
chr8_80856636_80856789	0.46	Gm31105	predicted gene, 31105	23228	0.16
chr10_69102086_69102245	0.46	Gm47107	predicted gene, 47107	4299	0.21
chr3_52605604_52605772	0.46	Gm10293	predicted pseudogene 10293	7147	0.26
chr7_116443673_116444404	0.45	AV356131	expressed sequence AV356131	463	0.52
chr7_30895336_30895491	0.45	D7Ertd128e	DNA segment, Chr 7, ERATO Doi 128, expressed	10382	0.07
chr19_58021843_58021994	0.45	Mir5623	microRNA 5623	29249	0.23
chr19_5831533_5832364	0.45	Neat1	nuclear paraspeckle assembly transcript 1 (non-protein coding)	3936	0.09
chr7_123407139_123407415	0.45	Lcmt1	leucine carboxyl methyltransferase 1	903	0.58
chr8_24457283_24457668	0.44	Gm44620	predicted gene 44620	10378	0.15
chr7_3331834_3332020	0.44	Cacng7	calcium channel, voltage-dependent, gamma subunit 7	1028	0.31
chr9_98986714_98987086	0.44	Faim	Fas apoptotic inhibitory molecule	493	0.73
chr15_83452182_83452447	0.44	Pacsin2	protein kinase C and casein kinase substrate in neurons 2	12238	0.15
chr1_60609032_60609279	0.44	Gm23762	predicted gene, 23762	4648	0.15
chr9_21725120_21725502	0.43	Ldlr	low density lipoprotein receptor	1670	0.23
chr6_28737275_28737426	0.43	Snd1	staphylococcal nuclease and tudor domain containing 1	27340	0.19
chr9_102737824_102737975	0.42	Gm5627	predicted gene 5627	1749	0.25
chr18_80254812_80254963	0.42	Slc66a2	solute carrier family 66 member 2	358	0.79
chr10_68259248_68259399	0.41	Arid5b	AT rich interactive domain 5B (MRF1-like)	19398	0.21
chr4_152027330_152027509	0.41	Zbtb48	zinc finger and BTB domain containing 48	218	0.87
chr7_114769396_114769572	0.41	Insc	INSC spindle orientation adaptor protein	710	0.68
chr13_43499439_43499647	0.41	Gm47683	predicted gene, 47683	624	0.64
chr7_119941261_119941568	0.41	Lyrm1	LYR motif containing 1	4456	0.17
chr17_12921475_12921639	0.40	Snora20	small nucleolar RNA, H/ACA box 20	1233	0.19
chr7_19457920_19458071	0.40	Mark4	MAP/microtubule affinity regulating kinase 4	800	0.36
chr2_158070723_158070992	0.40	2010009K17Rik	RIKEN cDNA 2010009K17 gene	20940	0.14
chr9_80067924_80068106	0.40	Senp6	SUMO/sentrin specific peptidase 6	198	0.93
chr18_54984622_54984821	0.39	Zfp608	zinc finger protein 608	5445	0.22
chr2_27696621_27697049	0.39	Rxra	retinoid X receptor alpha	12457	0.25
chr19_46627552_46627707	0.39	Wbp1l	WW domain binding protein 1 like	4228	0.16
chr11_100921491_100921782	0.38	Stat3	signal transducer and activator of transcription 3	13412	0.14
chr9_69290695_69290919	0.38	Rora	RAR-related orphan receptor alpha	1125	0.59

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of Zkscan3

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	1.0	GO:2000741	positive regulation of mesenchymal stem cell differentiation(GO:2000741)
0.2	0.7	GO:0032485	regulation of Ral protein signal transduction(GO:0032485)
0.1	0.4	GO:0044333	Wnt signaling pathway involved in digestive tract morphogenesis(GO:0044333)
0.1	0.4	GO:0090230	regulation of centromere complex assembly(GO:0090230)
0.1	0.8	GO:0060770	negative regulation of epithelial cell proliferation involved in prostate gland development(GO:0060770)
0.1	0.3	GO:0000087	mitotic M phase(GO:0000087)
0.1	0.3	GO:0006481	C-terminal protein methylation(GO:0006481)
0.1	0.3	GO:0060468	prevention of polyspermy(GO:0060468)
0.1	0.5	GO:0071985	multivesicular body sorting pathway(GO:0071985)
0.1	0.2	GO:0010046	response to mycotoxin(GO:0010046)
0.1	0.5	GO:0043102	amino acid salvage(GO:0043102) L-methionine biosynthetic process(GO:0071265) L-methionine salvage(GO:0071267)
0.1	0.4	GO:0061072	iris morphogenesis(GO:0061072)
0.1	0.2	GO:0002378	immunoglobulin biosynthetic process(GO:0002378)
0.1	0.2	GO:0007525	somatic muscle development(GO:0007525)
0.1	0.2	GO:0046499	S-adenosylmethioninamine metabolic process(GO:0046499)
0.1	0.1	GO:0046049	UMP biosynthetic process(GO:0006222) pyrimidine ribonucleoside monophosphate metabolic process(GO:0009173) pyrimidine ribonucleoside monophosphate biosynthetic process(GO:0009174) UMP metabolic process(GO:0046049)
0.1	0.3	GO:0061073	ciliary body morphogenesis(GO:0061073)
0.1	0.1	GO:1900019	regulation of protein kinase C activity(GO:1900019) positive regulation of protein kinase C activity(GO:1900020)
0.1	0.3	GO:0001927	exocyst assembly(GO:0001927)
0.1	0.3	GO:0043097	pyrimidine-containing compound salvage(GO:0008655) pyrimidine nucleoside salvage(GO:0043097)
0.1	0.2	GO:0097118	neuroligin clustering involved in postsynaptic membrane assembly(GO:0097118)
0.1	0.4	GO:0035735	intraciliary transport involved in cilium morphogenesis(GO:0035735)
0.1	0.2	GO:0045896	regulation of transcription during mitosis(GO:0045896) positive regulation of transcription during mitosis(GO:0045897)
0.1	0.6	GO:0046085	adenosine metabolic process(GO:0046085)
0.1	0.2	GO:0043435	response to corticotropin-releasing hormone(GO:0043435) cellular response to corticotropin-releasing hormone stimulus(GO:0071376)
0.1	0.2	GO:0021553	olfactory nerve development(GO:0021553)
0.1	0.3	GO:0018101	protein citrullination(GO:0018101)
0.1	0.2	GO:2001274	negative regulation of glucose import in response to insulin stimulus(GO:2001274)
0.1	0.2	GO:0006114	glycerol biosynthetic process(GO:0006114)
0.1	0.2	GO:1904016	response to Thyroglobulin triiodothyronine(GO:1904016) cellular response to Thyroglobulin triiodothyronine(GO:1904017)
0.1	0.2	GO:0036092	phosphatidylinositol-3-phosphate biosynthetic process(GO:0036092)
0.1	0.5	GO:0035563	positive regulation of chromatin binding(GO:0035563)
0.0	0.2	GO:0009256	10-formyltetrahydrofolate metabolic process(GO:0009256)
0.0	0.2	GO:1903964	monounsaturated fatty acid metabolic process(GO:1903964) monounsaturated fatty acid biosynthetic process(GO:1903966)
0.0	0.4	GO:0005981	regulation of glycogen catabolic process(GO:0005981)
0.0	0.6	GO:0090136	epithelial cell-cell adhesion(GO:0090136)
0.0	0.1	GO:0070318	positive regulation of G0 to G1 transition(GO:0070318)
0.0	0.5	GO:0019985	translesion synthesis(GO:0019985)
0.0	0.6	GO:0009143	nucleoside triphosphate catabolic process(GO:0009143)
0.0	0.1	GO:0045626	negative regulation of T-helper 1 cell differentiation(GO:0045626)
0.0	0.1	GO:0046341	CDP-diacylglycerol metabolic process(GO:0046341)
0.0	0.1	GO:0001692	histamine metabolic process(GO:0001692)
0.0	0.3	GO:0061304	retinal blood vessel morphogenesis(GO:0061304)
0.0	0.3	GO:0045650	negative regulation of macrophage differentiation(GO:0045650)
0.0	0.1	GO:0045715	negative regulation of low-density lipoprotein particle receptor biosynthetic process(GO:0045715)
0.0	0.2	GO:0051661	maintenance of centrosome location(GO:0051661)
0.0	0.1	GO:0060528	secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development(GO:0060528)
0.0	0.2	GO:0001561	fatty acid alpha-oxidation(GO:0001561)
0.0	0.1	GO:0072310	glomerular visceral epithelial cell development(GO:0072015) glomerular epithelial cell development(GO:0072310)
0.0	0.1	GO:0060448	dichotomous subdivision of terminal units involved in lung branching(GO:0060448)
0.0	0.1	GO:0060319	primitive erythrocyte differentiation(GO:0060319)
0.0	0.2	GO:1903689	regulation of wound healing, spreading of epidermal cells(GO:1903689)
0.0	0.3	GO:0030206	chondroitin sulfate biosynthetic process(GO:0030206)
0.0	0.1	GO:1903935	neurofilament bundle assembly(GO:0033693) peripheral nervous system neuron axonogenesis(GO:0048936) response to sodium arsenite(GO:1903935)
0.0	0.1	GO:0009130	pyrimidine nucleoside monophosphate biosynthetic process(GO:0009130) deoxyribonucleoside monophosphate biosynthetic process(GO:0009157) pyrimidine deoxyribonucleoside monophosphate biosynthetic process(GO:0009177)
0.0	0.1	GO:0016554	cytidine to uridine editing(GO:0016554)
0.0	0.2	GO:0035999	tetrahydrofolate interconversion(GO:0035999)
0.0	0.2	GO:0071830	chylomicron remnant clearance(GO:0034382) triglyceride-rich lipoprotein particle clearance(GO:0071830)
0.0	0.2	GO:0006477	protein sulfation(GO:0006477)
0.0	0.2	GO:0034625	fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.0	0.1	GO:0032484	Ral protein signal transduction(GO:0032484) regulation of exocyst localization(GO:0060178)
0.0	0.2	GO:1901838	positive regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter(GO:1901838)
0.0	0.1	GO:0006768	biotin metabolic process(GO:0006768)
0.0	0.2	GO:0021894	cerebral cortex GABAergic interneuron development(GO:0021894)
0.0	0.1	GO:1903753	negative regulation of p38MAPK cascade(GO:1903753)
0.0	0.1	GO:0034421	post-translational protein acetylation(GO:0034421)
0.0	0.1	GO:0006597	spermine biosynthetic process(GO:0006597)
0.0	0.1	GO:0071335	hair follicle cell proliferation(GO:0071335)
0.0	0.1	GO:1903416	response to glycoside(GO:1903416)
0.0	0.1	GO:0090292	nuclear matrix organization(GO:0043578) nuclear matrix anchoring at nuclear membrane(GO:0090292)
0.0	0.1	GO:0070836	caveola assembly(GO:0070836)
0.0	0.1	GO:0072675	osteoclast fusion(GO:0072675)
0.0	0.1	GO:0000056	ribosomal small subunit export from nucleus(GO:0000056)
0.0	0.1	GO:0048696	regulation of collateral sprouting in absence of injury(GO:0048696)
0.0	0.2	GO:0034312	diol biosynthetic process(GO:0034312) sphingosine biosynthetic process(GO:0046512)
0.0	0.2	GO:0043353	enucleate erythrocyte differentiation(GO:0043353)
0.0	0.1	GO:0034755	iron ion transmembrane transport(GO:0034755)
0.0	0.0	GO:0003273	cell migration involved in endocardial cushion formation(GO:0003273)
0.0	0.2	GO:1900262	regulation of DNA-directed DNA polymerase activity(GO:1900262) positive regulation of DNA-directed DNA polymerase activity(GO:1900264)
0.0	0.2	GO:0019511	peptidyl-proline hydroxylation(GO:0019511)
0.0	0.1	GO:0060921	sinoatrial node cell differentiation(GO:0060921)
0.0	0.1	GO:0015015	heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.0	0.3	GO:0000132	establishment of mitotic spindle orientation(GO:0000132)
0.0	0.3	GO:0070234	positive regulation of T cell apoptotic process(GO:0070234)
0.0	0.1	GO:0019254	carnitine metabolic process, CoA-linked(GO:0019254)
0.0	0.1	GO:1900242	regulation of synaptic vesicle endocytosis(GO:1900242)
0.0	0.5	GO:0002021	response to dietary excess(GO:0002021)
0.0	0.0	GO:1900825	regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900825)
0.0	0.2	GO:0051152	positive regulation of smooth muscle cell differentiation(GO:0051152)
0.0	0.1	GO:0071873	response to norepinephrine(GO:0071873)
0.0	0.5	GO:0071398	cellular response to fatty acid(GO:0071398)
0.0	0.1	GO:0051387	negative regulation of neurotrophin TRK receptor signaling pathway(GO:0051387)
0.0	0.2	GO:0006108	malate metabolic process(GO:0006108)
0.0	0.0	GO:0046103	inosine biosynthetic process(GO:0046103)
0.0	0.1	GO:0002432	granuloma formation(GO:0002432)
0.0	0.1	GO:0016576	histone dephosphorylation(GO:0016576)
0.0	0.0	GO:0070358	actin polymerization-dependent cell motility(GO:0070358)
0.0	0.1	GO:0050955	thermoception(GO:0050955)
0.0	0.1	GO:0016266	O-glycan processing(GO:0016266)
0.0	0.1	GO:0061366	behavioral response to chemical pain(GO:0061366) behavioral response to formalin induced pain(GO:0061368)
0.0	0.1	GO:0043313	regulation of neutrophil degranulation(GO:0043313)
0.0	0.1	GO:0051919	positive regulation of fibrinolysis(GO:0051919)
0.0	0.2	GO:0090051	negative regulation of cell migration involved in sprouting angiogenesis(GO:0090051)
0.0	0.2	GO:0036315	cellular response to sterol(GO:0036315)
0.0	0.1	GO:0071442	positive regulation of histone H3-K14 acetylation(GO:0071442)
0.0	0.1	GO:0019919	peptidyl-arginine methylation, to asymmetrical-dimethyl arginine(GO:0019919)
0.0	0.1	GO:0061623	galactose catabolic process via UDP-galactose(GO:0033499) glycolytic process from galactose(GO:0061623)
0.0	0.8	GO:0043388	positive regulation of DNA binding(GO:0043388)
0.0	0.0	GO:1901668	regulation of superoxide dismutase activity(GO:1901668)
0.0	0.1	GO:0070327	thyroid hormone transport(GO:0070327)
0.0	0.2	GO:0001973	adenosine receptor signaling pathway(GO:0001973)
0.0	0.0	GO:0051795	positive regulation of catagen(GO:0051795)
0.0	0.1	GO:0072386	plus-end-directed vesicle transport along microtubule(GO:0072383) plus-end-directed organelle transport along microtubule(GO:0072386)
0.0	0.1	GO:0006295	nucleotide-excision repair, DNA incision, 3'-to lesion(GO:0006295)
0.0	0.2	GO:0030575	nuclear body organization(GO:0030575)
0.0	0.1	GO:0008616	queuosine biosynthetic process(GO:0008616) queuosine metabolic process(GO:0046116)
0.0	0.2	GO:0042559	pteridine-containing compound biosynthetic process(GO:0042559)
0.0	0.1	GO:0033031	positive regulation of neutrophil apoptotic process(GO:0033031)
0.0	0.2	GO:0042359	vitamin D metabolic process(GO:0042359)
0.0	0.2	GO:0032988	ribonucleoprotein complex disassembly(GO:0032988)
0.0	0.1	GO:0045585	regulation of cytotoxic T cell differentiation(GO:0045583) positive regulation of cytotoxic T cell differentiation(GO:0045585)
0.0	0.1	GO:0030497	fatty acid elongation(GO:0030497)
0.0	0.1	GO:0060613	fat pad development(GO:0060613)
0.0	0.5	GO:0042832	defense response to protozoan(GO:0042832)
0.0	0.1	GO:0043569	negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569)
0.0	0.1	GO:0070126	mitochondrial translational termination(GO:0070126)
0.0	0.1	GO:0060414	aorta smooth muscle tissue morphogenesis(GO:0060414)
0.0	0.1	GO:0002072	optic cup morphogenesis involved in camera-type eye development(GO:0002072)
0.0	0.0	GO:0006106	fumarate metabolic process(GO:0006106)
0.0	0.1	GO:0021555	midbrain-hindbrain boundary morphogenesis(GO:0021555)
0.0	0.0	GO:0018199	peptidyl-glutamine modification(GO:0018199)
0.0	0.8	GO:0032543	mitochondrial translation(GO:0032543)
0.0	0.1	GO:0021648	vestibulocochlear nerve morphogenesis(GO:0021648)
0.0	0.1	GO:0086013	membrane repolarization during cardiac muscle cell action potential(GO:0086013)
0.0	0.3	GO:0032515	negative regulation of phosphoprotein phosphatase activity(GO:0032515)
0.0	0.0	GO:0006562	proline catabolic process(GO:0006562)
0.0	0.2	GO:0015937	coenzyme A biosynthetic process(GO:0015937)
0.0	0.1	GO:0000972	transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery(GO:0000972)
0.0	0.1	GO:0034080	CENP-A containing nucleosome assembly(GO:0034080) CENP-A containing chromatin organization(GO:0061641)
0.0	0.0	GO:0051344	negative regulation of cyclic-nucleotide phosphodiesterase activity(GO:0051344)
0.0	0.1	GO:0006551	leucine metabolic process(GO:0006551)
0.0	0.0	GO:2000211	regulation of glutamate metabolic process(GO:2000211)
0.0	0.0	GO:0018197	peptidyl-aspartic acid modification(GO:0018197)
0.0	0.5	GO:0060325	face morphogenesis(GO:0060325)
0.0	0.1	GO:0042518	negative regulation of tyrosine phosphorylation of Stat3 protein(GO:0042518)
0.0	0.0	GO:0046271	phenylpropanoid catabolic process(GO:0046271)
0.0	0.1	GO:0008078	mesodermal cell migration(GO:0008078)
0.0	0.0	GO:0045297	mating plug formation(GO:0042628) post-mating behavior(GO:0045297)
0.0	0.1	GO:0090666	scaRNA localization to Cajal body(GO:0090666)
0.0	0.0	GO:0003072	regulation of blood vessel size by renin-angiotensin(GO:0002034) renal control of peripheral vascular resistance involved in regulation of systemic arterial blood pressure(GO:0003072)
0.0	0.0	GO:0018171	peptidyl-cysteine oxidation(GO:0018171)
0.0	0.3	GO:0006376	mRNA splice site selection(GO:0006376)
0.0	0.3	GO:0001574	ganglioside biosynthetic process(GO:0001574)
0.0	0.1	GO:0050651	dermatan sulfate proteoglycan biosynthetic process(GO:0050651)
0.0	0.1	GO:0080154	regulation of fertilization(GO:0080154)
0.0	0.4	GO:0032728	positive regulation of interferon-beta production(GO:0032728)
0.0	0.1	GO:0060391	positive regulation of SMAD protein import into nucleus(GO:0060391)
0.0	0.1	GO:1904424	regulation of GTP binding(GO:1904424)
0.0	0.1	GO:0060050	positive regulation of protein glycosylation(GO:0060050)
0.0	0.1	GO:0006547	histidine metabolic process(GO:0006547)
0.0	0.0	GO:0021843	substrate-independent telencephalic tangential migration(GO:0021826) interneuron migration from the subpallium to the cortex(GO:0021830) substrate-independent telencephalic tangential interneuron migration(GO:0021843)
0.0	0.1	GO:0018298	protein-chromophore linkage(GO:0018298)
0.0	0.1	GO:0006977	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest(GO:0006977)
0.0	0.1	GO:0001712	ectodermal cell fate commitment(GO:0001712)
0.0	0.0	GO:0061724	lipophagy(GO:0061724)
0.0	0.0	GO:0060743	epithelial cell maturation involved in prostate gland development(GO:0060743)
0.0	0.1	GO:0070986	left/right axis specification(GO:0070986)
0.0	0.0	GO:0071316	cellular response to nicotine(GO:0071316)
0.0	0.1	GO:0017182	peptidyl-diphthamide metabolic process(GO:0017182) peptidyl-diphthamide biosynthetic process from peptidyl-histidine(GO:0017183)
0.0	0.1	GO:1905206	positive regulation of hydrogen peroxide-mediated programmed cell death(GO:1901300) positive regulation of hydrogen peroxide-induced cell death(GO:1905206)
0.0	0.1	GO:0019482	beta-alanine metabolic process(GO:0019482)
0.0	0.0	GO:0043490	malate-aspartate shuttle(GO:0043490)
0.0	0.1	GO:0035360	positive regulation of peroxisome proliferator activated receptor signaling pathway(GO:0035360)
0.0	0.0	GO:0021827	cerebral cortex tangential migration using cell-cell interactions(GO:0021823) postnatal olfactory bulb interneuron migration(GO:0021827)
0.0	0.1	GO:0010587	miRNA catabolic process(GO:0010587)
0.0	0.0	GO:0090435	protein localization to nuclear envelope(GO:0090435)
0.0	0.0	GO:0051684	maintenance of Golgi location(GO:0051684)
0.0	0.0	GO:0097374	sensory neuron axon guidance(GO:0097374)
0.0	0.1	GO:2000643	positive regulation of early endosome to late endosome transport(GO:2000643)
0.0	0.1	GO:1901978	positive regulation of cell cycle checkpoint(GO:1901978)
0.0	0.1	GO:0015808	L-alanine transport(GO:0015808)
0.0	0.2	GO:0006098	pentose-phosphate shunt(GO:0006098)
0.0	0.1	GO:0038063	collagen-activated tyrosine kinase receptor signaling pathway(GO:0038063)
0.0	0.0	GO:0006987	activation of signaling protein activity involved in unfolded protein response(GO:0006987)
0.0	0.0	GO:0045875	negative regulation of sister chromatid cohesion(GO:0045875)
0.0	0.0	GO:0019856	'de novo' pyrimidine nucleobase biosynthetic process(GO:0006207) pyrimidine nucleobase biosynthetic process(GO:0019856)
0.0	0.1	GO:1903546	protein localization to photoreceptor outer segment(GO:1903546)
0.0	0.0	GO:0010482	epidermal cell division(GO:0010481) regulation of epidermal cell division(GO:0010482)
0.0	0.0	GO:0060737	prostate epithelial cord elongation(GO:0060523) prostate gland morphogenetic growth(GO:0060737)
0.0	0.0	GO:0031627	telomeric loop formation(GO:0031627)
0.0	0.0	GO:1902416	positive regulation of mRNA binding(GO:1902416) positive regulation of RNA binding(GO:1905216)
0.0	0.0	GO:0010040	response to iron(II) ion(GO:0010040)
0.0	0.0	GO:0018094	protein polyglycylation(GO:0018094)
0.0	0.0	GO:0046101	hypoxanthine metabolic process(GO:0046100) hypoxanthine biosynthetic process(GO:0046101)
0.0	0.2	GO:0042347	negative regulation of NF-kappaB import into nucleus(GO:0042347)
0.0	0.0	GO:0009448	gamma-aminobutyric acid metabolic process(GO:0009448)
0.0	0.1	GO:0070189	kynurenine metabolic process(GO:0070189)
0.0	0.0	GO:1901341	activation of store-operated calcium channel activity(GO:0032237) positive regulation of store-operated calcium channel activity(GO:1901341)
0.0	0.0	GO:1902023	L-arginine import(GO:0043091) arginine import(GO:0090467) L-arginine transport(GO:1902023)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.8	GO:0043203	axon hillock(GO:0043203)
0.1	0.2	GO:0071008	U2-type post-mRNA release spliceosomal complex(GO:0071008)
0.1	0.6	GO:0001527	microfibril(GO:0001527)
0.0	0.1	GO:0043293	apoptosome(GO:0043293)
0.0	0.1	GO:0008275	gamma-tubulin small complex(GO:0008275)
0.0	0.6	GO:0005736	DNA-directed RNA polymerase I complex(GO:0005736)
0.0	0.3	GO:0042587	glycogen granule(GO:0042587)
0.0	0.1	GO:0031074	nucleocytoplasmic shuttling complex(GO:0031074)
0.0	0.2	GO:0000347	THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445)
0.0	0.1	GO:0097418	neurofibrillary tangle(GO:0097418)
0.0	0.1	GO:0031429	box H/ACA snoRNP complex(GO:0031429) box H/ACA RNP complex(GO:0072588)
0.0	0.4	GO:0032580	Golgi cisterna membrane(GO:0032580)
0.0	0.2	GO:0001739	sex chromatin(GO:0001739)
0.0	0.2	GO:0098651	collagen type IV trimer(GO:0005587) network-forming collagen trimer(GO:0098642) collagen network(GO:0098645) basement membrane collagen trimer(GO:0098651)
0.0	0.2	GO:0090571	RNA polymerase II transcription repressor complex(GO:0090571)
0.0	0.8	GO:0000314	organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.0	0.2	GO:0005796	Golgi lumen(GO:0005796)
0.0	0.1	GO:0042827	platelet dense granule(GO:0042827)
0.0	0.1	GO:0097149	centralspindlin complex(GO:0097149)
0.0	0.2	GO:0031232	extrinsic component of external side of plasma membrane(GO:0031232)
0.0	0.6	GO:0002080	acrosomal membrane(GO:0002080)
0.0	0.3	GO:0016580	Sin3 complex(GO:0016580)
0.0	0.1	GO:0000172	ribonuclease MRP complex(GO:0000172)
0.0	0.1	GO:0044611	nuclear pore inner ring(GO:0044611)
0.0	0.2	GO:0031390	Ctf18 RFC-like complex(GO:0031390)
0.0	0.6	GO:0034451	centriolar satellite(GO:0034451)
0.0	0.3	GO:0098827	endoplasmic reticulum subcompartment(GO:0098827)
0.0	0.1	GO:0044326	dendritic spine neck(GO:0044326)
0.0	0.1	GO:0035867	alphav-beta3 integrin-IGF-1-IGF1R complex(GO:0035867)
0.0	0.0	GO:0030981	cortical microtubule cytoskeleton(GO:0030981)
0.0	0.3	GO:0097431	mitotic spindle pole(GO:0097431)
0.0	0.2	GO:0070852	cell body fiber(GO:0070852)
0.0	0.1	GO:0097425	smooth endoplasmic reticulum membrane(GO:0030868) smooth endoplasmic reticulum part(GO:0097425)
0.0	0.1	GO:0097433	dense body(GO:0097433)
0.0	0.1	GO:0070522	ERCC4-ERCC1 complex(GO:0070522)
0.0	0.1	GO:0000938	GARP complex(GO:0000938)
0.0	0.1	GO:0000276	mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.0	0.5	GO:0008305	integrin complex(GO:0008305)
0.0	0.1	GO:0001520	outer dense fiber(GO:0001520)
0.0	0.0	GO:0033186	CAF-1 complex(GO:0033186)
0.0	0.2	GO:0001741	XY body(GO:0001741)
0.0	0.2	GO:0005779	integral component of peroxisomal membrane(GO:0005779)
0.0	0.0	GO:0032444	activin responsive factor complex(GO:0032444)
0.0	1.0	GO:0034705	potassium channel complex(GO:0034705)
0.0	0.1	GO:0008024	cyclin/CDK positive transcription elongation factor complex(GO:0008024)
0.0	0.1	GO:0030015	CCR4-NOT core complex(GO:0030015)
0.0	0.1	GO:0036157	outer dynein arm(GO:0036157)
0.0	0.5	GO:0000118	histone deacetylase complex(GO:0000118)
0.0	0.5	GO:0032420	stereocilium(GO:0032420)
0.0	0.0	GO:0005588	collagen type V trimer(GO:0005588)
0.0	1.2	GO:0016607	nuclear speck(GO:0016607)
0.0	0.1	GO:0034992	microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.0	0.0	GO:0005968	Rab-protein geranylgeranyltransferase complex(GO:0005968)
0.0	0.1	GO:0005890	sodium:potassium-exchanging ATPase complex(GO:0005890)
0.0	0.1	GO:0070578	RISC-loading complex(GO:0070578)
0.0	0.2	GO:0000145	exocyst(GO:0000145)
0.0	0.2	GO:0030992	intraciliary transport particle B(GO:0030992)
0.0	0.1	GO:0045180	basal cortex(GO:0045180)
0.0	0.0	GO:0030891	VCB complex(GO:0030891)
0.0	0.1	GO:0031209	SCAR complex(GO:0031209)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.3	0.8	GO:0031800	type 3 metabotropic glutamate receptor binding(GO:0031800)
0.2	0.6	GO:0035529	NADH pyrophosphatase activity(GO:0035529)
0.2	0.8	GO:0008970	phosphatidylcholine 1-acylhydrolase activity(GO:0008970)
0.2	0.6	GO:0016509	long-chain-3-hydroxyacyl-CoA dehydrogenase activity(GO:0016509)
0.2	0.5	GO:0008898	S-adenosylmethionine-homocysteine S-methyltransferase activity(GO:0008898)
0.1	0.3	GO:0050510	N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity(GO:0050510)
0.1	0.7	GO:0035197	siRNA binding(GO:0035197)
0.1	0.2	GO:0001226	RNA polymerase II transcription corepressor binding(GO:0001226)
0.1	0.2	GO:0008142	oxysterol binding(GO:0008142)
0.1	0.2	GO:0019797	procollagen-proline 3-dioxygenase activity(GO:0019797)
0.1	0.2	GO:0003886	DNA (cytosine-5-)-methyltransferase activity(GO:0003886) DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates(GO:0051718)
0.1	0.3	GO:0004849	uridine kinase activity(GO:0004849)
0.1	0.3	GO:0047105	aminobutyraldehyde dehydrogenase activity(GO:0019145) 4-trimethylammoniobutyraldehyde dehydrogenase activity(GO:0047105)
0.1	0.6	GO:0001055	RNA polymerase II activity(GO:0001055)
0.1	0.3	GO:0004668	protein-arginine deiminase activity(GO:0004668)
0.1	0.2	GO:0000253	3-keto sterol reductase activity(GO:0000253)
0.1	0.2	GO:0004345	glucose-6-phosphate dehydrogenase activity(GO:0004345)
0.1	0.2	GO:0017153	sodium:dicarboxylate symporter activity(GO:0017153)
0.1	0.2	GO:0004470	malic enzyme activity(GO:0004470) malate dehydrogenase (decarboxylating) (NAD+) activity(GO:0004471)
0.1	0.2	GO:0072542	protein phosphatase activator activity(GO:0072542)
0.0	0.2	GO:0032896	palmitoyl-CoA 9-desaturase activity(GO:0032896)
0.0	0.1	GO:0004886	9-cis retinoic acid receptor activity(GO:0004886)
0.0	0.1	GO:0004605	phosphatidate cytidylyltransferase activity(GO:0004605)
0.0	0.1	GO:0004611	phosphoenolpyruvate carboxykinase activity(GO:0004611)
0.0	0.3	GO:0003836	beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.0	0.6	GO:0008327	methyl-CpG binding(GO:0008327)
0.0	0.2	GO:0015016	[heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.0	0.2	GO:0005275	amine transmembrane transporter activity(GO:0005275)
0.0	0.2	GO:0017040	ceramidase activity(GO:0017040)
0.0	0.2	GO:0070546	L-phenylalanine aminotransferase activity(GO:0070546)
0.0	0.5	GO:0008253	5'-nucleotidase activity(GO:0008253)
0.0	0.1	GO:0070883	pre-miRNA binding(GO:0070883)
0.0	0.4	GO:0097027	ubiquitin-protein transferase activator activity(GO:0097027)
0.0	0.2	GO:0050693	LBD domain binding(GO:0050693)
0.0	0.2	GO:0003997	acyl-CoA oxidase activity(GO:0003997)
0.0	0.7	GO:0004198	calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.0	0.4	GO:0016929	SUMO-specific protease activity(GO:0016929)
0.0	0.1	GO:0045504	dynein heavy chain binding(GO:0045504)
0.0	0.2	GO:0070324	thyroid hormone binding(GO:0070324)
0.0	0.0	GO:1990715	mRNA CDS binding(GO:1990715)
0.0	0.1	GO:0004594	pantothenate kinase activity(GO:0004594)
0.0	0.2	GO:0009922	fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)
0.0	0.2	GO:0016421	CoA carboxylase activity(GO:0016421)
0.0	0.2	GO:0035033	histone deacetylase regulator activity(GO:0035033)
0.0	0.4	GO:0015643	toxic substance binding(GO:0015643)
0.0	0.2	GO:0005499	vitamin D binding(GO:0005499)
0.0	0.1	GO:0035373	chondroitin sulfate proteoglycan binding(GO:0035373)
0.0	0.3	GO:0004176	ATP-dependent peptidase activity(GO:0004176)
0.0	0.1	GO:1990430	extracellular matrix protein binding(GO:1990430)
0.0	0.2	GO:0016742	hydroxymethyl-, formyl- and related transferase activity(GO:0016742)
0.0	0.3	GO:0052811	cobinamide kinase activity(GO:0008819) phytol kinase activity(GO:0010276) phenol kinase activity(GO:0018720) cyclin-dependent protein kinase activating kinase regulator activity(GO:0019914) inositol tetrakisphosphate 2-kinase activity(GO:0032942) heptose 7-phosphate kinase activity(GO:0033785) aminoglycoside phosphotransferase activity(GO:0034071) eukaryotic elongation factor-2 kinase regulator activity(GO:0042556) eukaryotic elongation factor-2 kinase activator activity(GO:0042557) LPPG:FO 2-phospho-L-lactate transferase activity(GO:0043743) cytidine kinase activity(GO:0043771) glycerate 2-kinase activity(GO:0043798) (S)-lactate 2-kinase activity(GO:0043841) phosphoserine:homoserine phosphotransferase activity(GO:0043899) L-seryl-tRNA(Sec) kinase activity(GO:0043915) phosphocholine transferase activity(GO:0044605) GTP-dependent polynucleotide kinase activity(GO:0051735) farnesol kinase activity(GO:0052668) CTP:2-trans,-6-trans-farnesol kinase activity(GO:0052669) geraniol kinase activity(GO:0052670) geranylgeraniol kinase activity(GO:0052671) CTP:geranylgeraniol kinase activity(GO:0052672) prenol kinase activity(GO:0052673) 1-phosphatidylinositol-5-kinase activity(GO:0052810) 1-phosphatidylinositol-3-phosphate 4-kinase activity(GO:0052811) phosphatidylinositol-3,4-bisphosphate 5-kinase activity(GO:0052812) inositol-3,4,6-trisphosphate 1-kinase activity(GO:0052835) inositol 5-diphosphate pentakisphosphate 5-kinase activity(GO:0052836) inositol diphosphate tetrakisphosphate kinase activity(GO:0052839)
0.0	0.1	GO:0051377	mannose-ethanolamine phosphotransferase activity(GO:0051377)
0.0	0.1	GO:0031750	D3 dopamine receptor binding(GO:0031750)
0.0	0.3	GO:0070182	DNA polymerase binding(GO:0070182)
0.0	0.1	GO:0050816	phosphothreonine binding(GO:0050816)
0.0	0.1	GO:0018479	benzaldehyde dehydrogenase (NAD+) activity(GO:0018479)
0.0	0.2	GO:0031957	very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.0	0.1	GO:0000171	ribonuclease MRP activity(GO:0000171)
0.0	0.1	GO:0034988	Fc-gamma receptor I complex binding(GO:0034988)
0.0	0.2	GO:0035005	1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.0	0.4	GO:0070530	K63-linked polyubiquitin binding(GO:0070530)
0.0	0.1	GO:0001075	transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly(GO:0001075)
0.0	0.2	GO:0051864	histone demethylase activity (H3-K36 specific)(GO:0051864)
0.0	0.1	GO:0019959	interleukin-8 binding(GO:0019959)
0.0	0.0	GO:0030284	estrogen receptor activity(GO:0030284)
0.0	0.7	GO:0018711	dihydrolipoamide branched chain acyltransferase activity(GO:0004147) palmitoleoyl [acyl-carrier-protein]-dependent acyltransferase activity(GO:0008951) serine O-acyltransferase activity(GO:0016412) O-succinyltransferase activity(GO:0016750) sinapoyltransferase activity(GO:0016752) O-sinapoyltransferase activity(GO:0016753) peptidyl-lysine N6-myristoyltransferase activity(GO:0018030) peptidyl-lysine N6-palmitoyltransferase activity(GO:0018031) benzoyl acetate-CoA thiolase activity(GO:0018711) 3-hydroxybutyryl-CoA thiolase activity(GO:0018712) 3-ketopimelyl-CoA thiolase activity(GO:0018713) N-palmitoyltransferase activity(GO:0019105) acyl-CoA N-acyltransferase activity(GO:0019186) protein-cysteine S-myristoyltransferase activity(GO:0019705) glucosaminyl-phosphotidylinositol O-acyltransferase activity(GO:0032216) ergosterol O-acyltransferase activity(GO:0034737) lanosterol O-acyltransferase activity(GO:0034738) naphthyl-2-oxomethyl-succinyl-CoA succinyl transferase activity(GO:0034848) 2,4,4-trimethyl-3-oxopentanoyl-CoA 2-C-propanoyl transferase activity(GO:0034851) 2-methylhexanoyl-CoA C-acetyltransferase activity(GO:0034915) butyryl-CoA 2-C-propionyltransferase activity(GO:0034919) 2,6-dimethyl-5-methylene-3-oxo-heptanoyl-CoA C-acetyltransferase activity(GO:0034945) L-2-aminoadipate N-acetyltransferase activity(GO:0043741) keto acid formate lyase activity(GO:0043806) azetidine-2-carboxylic acid acetyltransferase activity(GO:0046941) peptidyl-lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0052858) acetyl-CoA:L-lysine N6-acetyltransferase(GO:0090595)
0.0	0.1	GO:0019808	polyamine binding(GO:0019808)
0.0	0.3	GO:0005092	GDP-dissociation inhibitor activity(GO:0005092)
0.0	0.2	GO:0017160	Ral GTPase binding(GO:0017160)
0.0	0.1	GO:0019862	IgA binding(GO:0019862)
0.0	0.1	GO:0008479	queuine tRNA-ribosyltransferase activity(GO:0008479)
0.0	0.1	GO:0008599	protein phosphatase type 1 regulator activity(GO:0008599)
0.0	0.1	GO:1990239	steroid hormone binding(GO:1990239)
0.0	0.1	GO:0016406	carnitine O-acyltransferase activity(GO:0016406)
0.0	0.2	GO:0003689	DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.0	0.0	GO:0004705	JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.0	0.1	GO:0004687	myosin light chain kinase activity(GO:0004687)
0.0	0.1	GO:0004045	aminoacyl-tRNA hydrolase activity(GO:0004045)
0.0	0.2	GO:0005542	folic acid binding(GO:0005542)
0.0	0.1	GO:0048531	beta-1,3-galactosyltransferase activity(GO:0048531)
0.0	0.1	GO:0086008	voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization(GO:0086008)
0.0	0.0	GO:0004698	calcium-dependent protein kinase C activity(GO:0004698)
0.0	0.0	GO:0015183	L-aspartate transmembrane transporter activity(GO:0015183)
0.0	0.4	GO:0036002	pre-mRNA binding(GO:0036002)
0.0	0.0	GO:1901612	cardiolipin binding(GO:1901612)
0.0	0.2	GO:0070300	phosphatidic acid binding(GO:0070300)
0.0	0.1	GO:0005534	galactose binding(GO:0005534)
0.0	0.2	GO:0050321	tau-protein kinase activity(GO:0050321)
0.0	0.1	GO:0003917	DNA topoisomerase type I activity(GO:0003917)
0.0	0.0	GO:0003726	double-stranded RNA adenosine deaminase activity(GO:0003726)
0.0	0.1	GO:0030229	very-low-density lipoprotein particle receptor activity(GO:0030229)
0.0	0.1	GO:0046912	transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
0.0	0.1	GO:0035368	selenocysteine insertion sequence binding(GO:0035368)
0.0	0.1	GO:0008469	histone-arginine N-methyltransferase activity(GO:0008469) protein-arginine omega-N asymmetric methyltransferase activity(GO:0035242)
0.0	0.1	GO:0070513	death domain binding(GO:0070513)
0.0	0.1	GO:0004966	galanin receptor activity(GO:0004966)
0.0	0.0	GO:0005176	ErbB-2 class receptor binding(GO:0005176)
0.0	0.1	GO:0061665	SUMO ligase activity(GO:0061665)
0.0	0.0	GO:0015222	serotonin transmembrane transporter activity(GO:0015222)
0.0	0.2	GO:0030247	pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
0.0	1.2	GO:0005178	integrin binding(GO:0005178)
0.0	0.1	GO:0005280	hydrogen:amino acid symporter activity(GO:0005280)
0.0	0.0	GO:0015065	uridine nucleotide receptor activity(GO:0015065) G-protein coupled pyrimidinergic nucleotide receptor activity(GO:0071553)
0.0	0.1	GO:0016832	aldehyde-lyase activity(GO:0016832)
0.0	0.0	GO:0051032	nucleic acid transmembrane transporter activity(GO:0051032) RNA transmembrane transporter activity(GO:0051033)
0.0	0.2	GO:1990841	promoter-specific chromatin binding(GO:1990841)
0.0	0.5	GO:0050840	extracellular matrix binding(GO:0050840)
0.0	0.0	GO:0004103	choline kinase activity(GO:0004103)
0.0	0.2	GO:0045295	gamma-catenin binding(GO:0045295)
0.0	0.0	GO:0070051	fibrinogen binding(GO:0070051)
0.0	0.0	GO:0030350	iron-responsive element binding(GO:0030350)
0.0	0.1	GO:0016920	pyroglutamyl-peptidase activity(GO:0016920)
0.0	0.8	GO:0005089	Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.0	0.1	GO:0003847	1-alkyl-2-acetylglycerophosphocholine esterase activity(GO:0003847)
0.0	0.1	GO:0016892	endoribonuclease activity, producing 3'-phosphomonoesters(GO:0016892)
0.0	0.0	GO:0004065	arylsulfatase activity(GO:0004065)
0.0	0.2	GO:0042813	Wnt-activated receptor activity(GO:0042813)
0.0	0.1	GO:0008020	G-protein coupled photoreceptor activity(GO:0008020)
0.0	0.6	GO:0030295	protein kinase activator activity(GO:0030295)
0.0	0.0	GO:0097603	temperature-gated ion channel activity(GO:0097603)
0.0	0.1	GO:0019206	nucleoside kinase activity(GO:0019206)
0.0	0.1	GO:0051185	coenzyme transporter activity(GO:0051185)
0.0	0.0	GO:0004505	phenylalanine 4-monooxygenase activity(GO:0004505)
0.0	0.2	GO:0004653	polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.0	0.1	GO:0036310	annealing helicase activity(GO:0036310)
0.0	0.1	GO:0048407	platelet-derived growth factor binding(GO:0048407)
0.0	0.1	GO:0017166	vinculin binding(GO:0017166)
0.0	0.1	GO:0004985	opioid receptor activity(GO:0004985)
0.0	0.1	GO:0005005	transmembrane-ephrin receptor activity(GO:0005005)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.2	PID AVB3 INTEGRIN PATHWAY	Integrins in angiogenesis
0.0	0.3	SA G2 AND M PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.0	0.6	PID INTEGRIN CS PATHWAY	Integrin family cell surface interactions
0.0	0.0	PID PS1 PATHWAY	Presenilin action in Notch and Wnt signaling
0.0	1.3	PID ERA GENOMIC PATHWAY	Validated nuclear estrogen receptor alpha network
0.0	0.2	PID RANBP2 PATHWAY	Sumoylation by RanBP2 regulates transcriptional repression
0.0	0.2	PID S1P S1P4 PATHWAY	S1P4 pathway
0.0	0.2	PID SMAD2 3PATHWAY	Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.0	0.1	PID IL8 CXCR1 PATHWAY	IL8- and CXCR1-mediated signaling events
0.0	0.6	PID HDAC CLASSI PATHWAY	Signaling events mediated by HDAC Class I
0.0	0.5	PID NFAT 3PATHWAY	Role of Calcineurin-dependent NFAT signaling in lymphocytes

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.6	REACTOME RNA POL I PROMOTER OPENING	Genes involved in RNA Polymerase I Promoter Opening
0.1	0.7	REACTOME ABACAVIR TRANSPORT AND METABOLISM	Genes involved in Abacavir transport and metabolism
0.1	0.8	REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS	Genes involved in Ionotropic activity of Kainate Receptors
0.1	1.1	REACTOME CHONDROITIN SULFATE BIOSYNTHESIS	Genes involved in Chondroitin sulfate biosynthesis
0.0	0.8	REACTOME MICRORNA MIRNA BIOGENESIS	Genes involved in MicroRNA (miRNA) Biogenesis
0.0	0.7	REACTOME FATTY ACYL COA BIOSYNTHESIS	Genes involved in Fatty Acyl-CoA Biosynthesis
0.0	0.7	REACTOME SMOOTH MUSCLE CONTRACTION	Genes involved in Smooth Muscle Contraction
0.0	0.3	REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT	Genes involved in Chylomicron-mediated lipid transport
0.0	0.5	REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA	Genes involved in Circadian Repression of Expression by REV-ERBA
0.0	0.0	REACTOME RORA ACTIVATES CIRCADIAN EXPRESSION	Genes involved in RORA Activates Circadian Expression
0.0	0.3	REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA HYDROXYCHOLESTEROL	Genes involved in Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
0.0	0.3	REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY	Genes involved in TRAF3-dependent IRF activation pathway
0.0	0.5	REACTOME KERATAN SULFATE BIOSYNTHESIS	Genes involved in Keratan sulfate biosynthesis
0.0	0.2	REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE	Genes involved in Synthesis of PIPs at the early endosome membrane
0.0	0.3	REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION	Genes involved in Cyclin A/B1 associated events during G2/M transition
0.0	0.1	REACTOME ENDOSOMAL VACUOLAR PATHWAY	Genes involved in Endosomal/Vacuolar pathway
0.0	0.4	REACTOME SULFUR AMINO ACID METABOLISM	Genes involved in Sulfur amino acid metabolism
0.0	0.1	REACTOME RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES	Genes involved in Recruitment of NuMA to mitotic centrosomes
0.0	0.3	REACTOME PYRIMIDINE METABOLISM	Genes involved in Pyrimidine metabolism
0.0	0.2	REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS	Genes involved in Bile salt and organic anion SLC transporters
0.0	0.1	REACTOME NUCLEOTIDE BINDING DOMAIN LEUCINE RICH REPEAT CONTAINING RECEPTOR NLR SIGNALING PATHWAYS	Genes involved in Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
0.0	0.0	REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE	Genes involved in mRNA Decay by 3' to 5' Exoribonuclease
0.0	0.1	REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING	Genes involved in Formation of ATP by chemiosmotic coupling
0.0	0.1	REACTOME VITAMIN B5 PANTOTHENATE METABOLISM	Genes involved in Vitamin B5 (pantothenate) metabolism
0.0	0.1	REACTOME METABOLISM OF POLYAMINES	Genes involved in Metabolism of polyamines
0.0	0.2	REACTOME INSULIN SYNTHESIS AND PROCESSING	Genes involved in Insulin Synthesis and Processing